id category name description provided_by OBO:APOLLO_SV_00000008 biolink:NamedThing software development A planned process that has specified output a software product and that involves the creation of source code. RBO_relaxed.owl OBI:0000011 biolink:NamedThing planned process A process that realizes a plan which is the concretization of a plan specification. RBO_relaxed.owl OBO:APOLLO_SV_00000796 biolink:NamedThing dataset creating A planned process that has a data set as its specified output. RBO_relaxed.owl ENVO:01000785 biolink:NamedThing material extraction process A planned process during which a portion of environmental material is removed from a material entity. RBO_relaxed.owl ENVO:01000993 biolink:NamedThing manufacturing process A planned process during which raw or recycled materials are transformed into products for use or sale using labour and machines, tools, chemical and biological processing, or formulation. RBO_relaxed.owl ENVO:01000996 biolink:NamedThing human-directed construction process An process during which natural or manufactured materials and products are processed and arranged by humans or their technology into structures. RBO_relaxed.owl ENVO:01001436 biolink:NamedThing planned environmental usage process A planned process during which humans access and obtain resources, benefits, or services from a natural or anthropised ecosystem. RBO_relaxed.owl ENVO:02500026 biolink:NamedThing anthropogenic modulatory intervention process A process during which humans apply technology to alter the magnitude, duration, rate, or impact of an environmental process. RBO_relaxed.owl ENVO:02500041 biolink:NamedThing environmental monitoring An process in which environmental parameters and variables are continually assayed. RBO_relaxed.owl OBI:0000070 biolink:NamedThing assay A planned process with the objective to produce information about the material entity that is the evaluant, by physically examining it or its proxies. RBO_relaxed.owl OBI:0000094 biolink:NamedThing material processing A planned process which results in physical changes in a specified input material RBO_relaxed.owl OBI:0000338 biolink:NamedThing drawing a conclusion based on data A planned process in which data gathered in an investigation is evaluated in the context of existing knowledge with the objective to generate more general conclusions or to conclude that the data does not allow one to draw general conclusion RBO_relaxed.owl OBI:0000659 biolink:NamedThing specimen collection process A planned process with the objective of collecting a specimen. RBO_relaxed.owl OBI:0200000 biolink:NamedThing data transformation A planned process that produces output data from input data. RBO_relaxed.owl OBI:0200111 biolink:NamedThing data visualization A planned process with the objective to graphically represent some data by inputing the data and outputting images, diagrams or animations. RBO_relaxed.owl OBO:RBO_00000082 biolink:NamedThing radiobiology study type The theme or modality of an experimental, theoretical, critical or summative study involving radiation, radioactive materials including their impacts on orgnisms and society. RBO_relaxed.owl OBO:RBO_00002002 biolink:NamedThing planned radiation exposure Planned exposure of an entity to radiation of any type, for example as part of a medical or experimental procedure with the intention of exposing the entity to radiation energy internally or externally. RBO_relaxed.owl OBO:RBO_00002008 biolink:NamedThing planned anthropogenic radiation exposure Planned exposure to radiation generated through a device or exposure to a source emitting ionising radiation RBO_relaxed.owl OBO:RBO_00002118 biolink:NamedThing radioactive decay A process involving the emission of energy from an atomic nucleus resulting in change in the character of the nucleus RBO_relaxed.owl OBO:RBO_00015022 biolink:NamedThing track formation RBO_relaxed.owl BFO:0000002 biolink:NamedThing continuant An entity that exists in full at any time in which it exists at all, persists through time while maintaining its identity and has no temporal parts. RBO_relaxed.owl BFO:0000001 biolink:NamedThing entity RBO_relaxed.owl BFO:0000003 biolink:NamedThing occurrent An entity that has temporal parts and that happens, unfolds or develops through time. RBO_relaxed.owl BFO:0000004 biolink:NamedThing independent continuant A continuant that is a bearer of quality and realizable entity entities, in which other entities inhere and which itself cannot inhere in anything.|b is an independent continuant = Def. b is a continuant which is such that there is no c and no t such that b s-depends_on c at t. (axiom label in BFO2 Reference: [017-002]) RBO_relaxed.owl BFO:0000020 biolink:NamedThing specifically dependent continuant A continuant that inheres in or is borne by other entities. Every instance of A requires some specific instance of B which must always be the same.|An experimental factor which is a property or characteristic of some other entity. For example, the mouse has the colour white.|b is a relational specifically dependent continuant = Def. b is a specifically dependent continuant and there are n > 1 independent continuants c1, … cn which are not spatial regions are such that for all 1 i < j n, ci and cj share no common parts, are such that for each 1 i n, b s-depends_on ci at every time t during the course of b’s existence (axiom label in BFO2 Reference: [131-004])|b is a specifically dependent continuant = Def. b is a continuant & there is some independent continuant c which is not a spatial region and which is such that b s-depends_on c at every time t during the course of b’s existence. (axiom label in BFO2 Reference: [050-003]) RBO_relaxed.owl BFO:0000031 biolink:NamedThing generically dependent continuant A continuant that is dependent on one or other independent continuant bearers. For every instance of A requires some instance of (an independent continuant type) B but which instance of B serves can change from time to time.|b is a generically dependent continuant = Def. b is a continuant that g-depends_on one or more other entities. (axiom label in BFO2 Reference: [074-001]) RBO_relaxed.owl BFO:0000006 biolink:NamedThing spatial region RBO_relaxed.owl BFO:0000141 biolink:NamedThing immaterial entity RBO_relaxed.owl BFO:0000029 biolink:NamedThing site RBO_relaxed.owl BFO:0000140 biolink:NamedThing continuant fiat boundary b is a continuant fiat boundary = Def. b is an immaterial entity that is of zero, one or two dimensions and does not include a spatial region as part. (axiom label in BFO2 Reference: [029-001]) RBO_relaxed.owl UBERON:0000466 biolink:NamedThing immaterial anatomical entity Anatomical entity that has no mass. RBO_relaxed.owl BFO:0000015 biolink:NamedThing process A process is an entity that exists in time by occurring or happening, has temporal parts and always involves and depends on some entity during the time it occurs.|An occurrent that has temporal proper parts and for some time t, p s-depends_on some material entity at t.|p is a process = Def. p is an occurrent that has temporal proper parts and for some time t, p s-depends_on some material entity at t. (axiom label in BFO2 Reference: [083-003]) RBO_relaxed.owl UBERON:0000000 biolink:NamedThing processual entity An occurrent [span:Occurrent] that exists in time by occurring or happening, has temporal parts and always involves and depends on some entity. RBO_relaxed.owl BFO:0000016 biolink:NamedThing disposition A disposition is an entity that causes a specific process or transformation in an entity in which it inheres, under specific circumstances and in conjunction with the laws of nature. For example, the disposition of vegetables to decay when not refrigerated, the disposition of blood to coagulate, the disposition of a patient with a weakened immune system to contract disease. RBO_relaxed.owl BFO:0000017 biolink:NamedThing realizable_entity A specifically dependent continuant that inheres in continuant entities and are not exhibited in full at every time in which it inheres in an entity or group of entities. The exhibition or actualization of a realizable entity is a particular manifestation, functioning or process that occurs under certain circumstances. RBO_relaxed.owl OBI:0000260 biolink:NamedThing plan RBO_relaxed.owl BFO:0000019 biolink:NamedThing quality A quality is an entity that describes some aspect which is intrinsic to that particular object and is dependent on or more material entities in which it inheres in or is borne by. Example the color of a tomato, the ambient temperature of air, the circumference of a waist, the shape of a nose, the mass of a piece of gold, the weight of a chimpanzee RBO_relaxed.owl OBO:COB_0000120 biolink:NamedThing information representation RBO_relaxed.owl PATO:0000001 biolink:NamedThing quality A dependent entity that inheres in a bearer by virtue of how the bearer is related to other entities RBO_relaxed.owl BFO:0000023 biolink:NamedThing role A realizable entity the manifestation of which brings about some result or end that is not essential to a continuant in virtue of the kind of thing that it is but that can be served or participated in by that kind of continuant in some kinds of natural, social or institutional contexts.|A role is an entity which is borne in a material entity in some kinds of natural, social or institutional contexts, but which is not essential to the fundamental definition of that material entity (i.e. the material entity exists with or without the role). For example, the role of a person as a surgeon, the role of an artificial heart in pumping blood, the role of a chemical compound in an experiment, the role of a drug in the treatment of a disease. RBO_relaxed.owl CHEBI:50906 biolink:NamedThing role A role is particular behaviour which a material entity may exhibit. RBO_relaxed.owl CHEBI:24432 biolink:NamedThing biological role A role played by the molecular entity or part thereof within a biological context. RBO_relaxed.owl CHEBI:33232 biolink:NamedThing application Intended use of the molecular entity or part thereof by humans. RBO_relaxed.owl CHEBI:51086 biolink:NamedThing chemical role A role played by the molecular entity or part thereof within a chemical context. RBO_relaxed.owl ENVO:01000665 biolink:NamedThing waste role A role that is realized in some process wherein the bearer is discarded or not utilized further. RBO_relaxed.owl OBI:0000017 biolink:NamedThing regulatory role a role which inheres in material entities and is realized in the processes of making, enforcing or being defined by legislation or orders issued by a governmental body. RBO_relaxed.owl OBI:0000112 biolink:NamedThing specimen role a role borne by a material entity that is gained during a specimen collection process and that can be realized by use of the specimen in an investigation RBO_relaxed.owl OBI:0000571 biolink:NamedThing manufacturer role Manufacturer role is a role which inheres in a person or organization and which is realized by a manufacturing process. RBO_relaxed.owl OBI:0000947 biolink:NamedThing service provider role is a role which inheres in a person or organization and is realized in in a planned process which provides access to training, materials or execution of protocols for an organization or person RBO_relaxed.owl OBO:RBO_00000111 biolink:NamedThing occupational role A set of behaviours that have some socially agreed upon function and for which there is an accepted code of norms. This may refer to a role within an organisation or within society as a whole. For example a Profession” can be defined as a cluster of occupational roles, or roles in which the incumbents perform certain functions valued in the organisation or society. RBO_relaxed.owl SEPIO:0000048 biolink:NamedThing agent role RBO_relaxed.owl BFO:0000024 biolink:NamedThing fiat object part RBO_relaxed.owl BFO:0000040 biolink:NamedThing material entity A material entity is an entity that exists in full during the length of time of its existence, persists through this time while maintaining its identity and has no temporal parts. For example a heart, a human, a fly, a microarray.|An independent continuant that is spatially extended whose identity is independent of that of other entities and can be maintained through time. RBO_relaxed.owl BFO:0000027 biolink:NamedThing object aggregate RBO_relaxed.owl BFO:0000030 biolink:NamedThing object RBO_relaxed.owl CHEBI:24431 biolink:NamedThing chemical entity A chemical entity is a physical entity of interest in chemistry including molecular entities, parts thereof, and chemical substances. RBO_relaxed.owl CHEBI:36342 biolink:NamedThing subatomic particle A particle smaller than an atom. RBO_relaxed.owl OBO:CHMO_0000993 biolink:NamedThing portion of material An independent material continuant that is self-connected and retains its identity over time. RBO_relaxed.owl OBO:COB_0000011 biolink:NamedThing atom A material entity consisting of exactly one atomic nucleus and the electron(s) orbiting it. RBO_relaxed.owl OBO:COB_0000122 biolink:NamedThing physical information carrier RBO_relaxed.owl ENVO:00000070 biolink:NamedThing human construction A construction that has been assembled by deliberate human effort. RBO_relaxed.owl ENVO:00003074 biolink:NamedThing manufactured product A material entity that has been processed by humans or their technology in any way, including intermediate products as well as final products. RBO_relaxed.owl ENVO:01000281 biolink:NamedThing layer A layer is a quantity of some material which is spatially continuous, has comparable thickness, and usually covers some surface. RBO_relaxed.owl ENVO:01001813 biolink:NamedThing construction A material entity which has been assembled through the intentional, instinctual, or deliberately programmed efforts of an organism or machine. RBO_relaxed.owl GO:0005575 biolink:NamedThing cellular_component A location, relative to cellular compartments and structures, occupied by a macromolecular machine when it carries out a molecular function. There are two ways in which the gene ontology describes locations of gene products: (1) relative to cellular structures (e.g., cytoplasmic side of plasma membrane) or compartments (e.g., mitochondrion), and (2) the stable macromolecular complexes of which they are parts (e.g., the ribosome).|A location, relative to cellular compartments and structures, occupied by a macromolecular machine. There are three types of cellular components described in the gene ontology: (1) the cellular anatomical entity where a gene product carries out a molecular function (e.g., plasma membrane, cytoskeleton) or membrane-enclosed compartments (e.g., mitochondrion); (2) virion components, where viral proteins act, and (3) the stable macromolecular complexes of which gene product are parts (e.g., the clathrin complex).|A location, relative to cellular compartments and structures, occupied by a macromolecular machine. There are three types of cellular components described in the gene ontology: (1) the cellular anatomical entity where a gene product carries out a molecular function (e.g., plasma membrane, cytoskeleton) or membrane-enclosed compartments (e.g., mitochondrion); (2) virion components, where viral proteins act, and (3) the stable macromolecular complexes of which gene product are parts (e.g., the clathrin complex). RBO_relaxed.owl IAO:0000178 biolink:NamedThing material information bearer A material entity in which a concretization of an information content entity inheres. RBO_relaxed.owl OBI:0000047 biolink:NamedThing processed material Is a material entity that is created or changed during material processing. RBO_relaxed.owl OBI:0000181 biolink:NamedThing population A population is a group of material entities consisting of individuals which share a particular characteristic such as inhabiting a particular region or area or ability to interbreed.|a population is a collection of individuals from the same taxonomic class living, counted or sampled at a particular site or in a particular area RBO_relaxed.owl OBI:0000245 biolink:NamedThing organization An entity that can bear roles, has members, and has a set of organization rules. Members of organizations are either organizations themselves or individual people. Members can bear specific organization member roles that are determined in the organization rules. The organization rules also determine how decisions are made on behalf of the organization by the organization members. RBO_relaxed.owl OBI:0000835 biolink:NamedThing manufacturer A person or organization that has a manufacturer role. RBO_relaxed.owl OBI:0002076 biolink:NamedThing collection of specimens A material entity that has two or more specimens as its parts. RBO_relaxed.owl OBI:0002989 biolink:NamedThing material supplier A person or organization that provides material supplies to other people or organizations. RBO_relaxed.owl OBI:0100026 biolink:NamedThing organism A material entity that is an individual living system, such as animal, plant, bacteria or virus, that is capable of replicating or reproducing, growth and maintenance in the right environment. An organism may be unicellular or made up, like humans, of many billions of cells divided into specialized tissues and organs.|A material entity that is an individual living system, such as animal, plant, bacteria or virus, that is capable of replicating or reproducing, growth and maintenance in the right environment. An organism may be unicellular or made up, like humans, of many billions of cells divided into specialized tissues and organs. E.g Drosophila melanogaster RBO_relaxed.owl OBI:0100051 biolink:NamedThing specimen A material entity that has the specimen role. RBO_relaxed.owl PCO:0000031 biolink:NamedThing organismal entity A material entity that is one or more organisms, viruses or viroids. RBO_relaxed.owl PO:0025131 biolink:NamedThing plant anatomical entity An anatomical entity that is or was part of a plant. RBO_relaxed.owl PR:000050567 biolink:NamedThing protein-containing material entity A material entity that minimally consists of a protein. RBO_relaxed.owl OBO:RBO_00000004 biolink:NamedThing tissue equivalent material Material presenting, when irradiated, interaction properties similar to those of soft tissue. RBO_relaxed.owl OBO:RBO_00005003 biolink:NamedThing charged particle A particle with a positive or negative electric charge RBO_relaxed.owl OBO:RBO_00005014 biolink:NamedThing radiation source A material entity which emits radiation RBO_relaxed.owl OBO:RBO_00015000 biolink:NamedThing radiation That energy which is transferred in space and time as part of the process of radiation (ENVO:01001023). RBO_relaxed.owl RO:0002577 biolink:NamedThing system A material entity consisting of multiple components that are causally integrated. RBO_relaxed.owl SO:0000704 biolink:NamedThing gene A region (or regions) that includes all of the sequence elements necessary to encode a functional transcript. A gene may include regulatory regions, transcribed regions and/or other functional sequence regions. RBO_relaxed.owl UBERON:0000465 biolink:NamedThing material anatomical entity Anatomical entity that has mass. RBO_relaxed.owl EFO:0004446 biolink:NamedThing biological macromolecule Anatomical structure which has as its parts one or more ordered aggregates of nucleotide, amino acid fatty acid or sugar molecules bonded to one another. RBO_relaxed.owl BFO:0000034 biolink:NamedThing function RBO_relaxed.owl DOID:4 biolink:NamedThing disease A disease is a disposition (i) to undergo pathological processes that (ii) exists in an organism because of one or more disorders in that organism. RBO_relaxed.owl ENVO:01003001 biolink:NamedThing water-holding capacity A disposition of a material entity which is realised when it is saturated with liquid water. RBO_relaxed.owl ENVO:2000015 biolink:NamedThing energy A disposition which is realized during the execution of work, the emission of heat, or the possession of mass. RBO_relaxed.owl UBERON:0001062 biolink:NamedThing anatomical entity Biological entity that is either an individual member of a biological species or constitutes the structural organization of an individual member of a biological species. RBO_relaxed.owl BFO:0000182 biolink:NamedThing history RBO_relaxed.owl OBO:COB_0000082 biolink:NamedThing planned process A process that is initiated by an agent who intends to carry out a plan to achieve an objective through one or more actions as described in a plan specification. RBO_relaxed.owl ENVO:02500000 biolink:NamedThing environmental system process A process in which includes the components of an environmental system as participants. RBO_relaxed.owl GO:0003674 biolink:NamedThing molecular_function A molecular process that can be carried out by the action of a single macromolecular machine, usually via direct physical interactions with other molecular entities. Function in this sense denotes an action, or activity, that a gene product (or a complex) performs. RBO_relaxed.owl GO:0008150 biolink:NamedThing biological_process A biological process is the execution of a genetically-encoded biological module or program. It consists of all the steps required to achieve the specific biological objective of the module. A biological process is accomplished by a particular set of molecular functions carried out by specific gene products (or macromolecular complexes), often in a highly regulated manner and in a particular temporal sequence.|A biological process represents a specific objective that the organism is genetically programmed to achieve. Biological processes are often described by their outcome or ending state, e.g., the biological process of cell division results in the creation of two daughter cells (a divided cell) from a single parent cell. A biological process is accomplished by a particular set of molecular functions carried out by specific gene products (or macromolecular complexes), often in a highly regulated manner and in a particular temporal sequence. RBO_relaxed.owl GO:0042391 biolink:NamedThing regulation of membrane potential Any process that modulates the establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane. RBO_relaxed.owl OBO:RBO_00000123 biolink:NamedThing biological process RBO_relaxed.owl OBO:RBO_00015006 biolink:NamedThing subatomic process Processes in which electrons or components of the atomic nucleus are participants. RBO_relaxed.owl EFO:0000399 biolink:NamedThing developmental stage A developmental stage is spatiotemporal region encompassing some part of the life cycle of an organism, e.g. blastula stage RBO_relaxed.owl OBO:CARO_0001010 biolink:NamedThing organism or virus or viroid Material anatomical entity that is a member of an individual species or is a viral or viroid particle. RBO_relaxed.owl PCO:0000000 biolink:NamedThing collection of organisms A material entity that consists of two or more organisms, viruses, or viroids. RBO_relaxed.owl CHEBI:10545 biolink:NamedThing electron Elementary particle not affected by the strong force having a spin 1/2, a negative elementary charge and a rest mass of 0.000548579903(13) u, or 0.51099906(15) MeV. RBO_relaxed.owl CHEBI:36338 biolink:NamedThing lepton Lepton is a fermion that does not experience the strong force (strong interaction). The term is derived from the Greek lambdaepsilonpitauomicronsigma (small, thin). RBO_relaxed.owl CHEBI:36356 biolink:NamedThing muon Elementary particle not affected by the strong force having a spin 1/2, a negative elementary charge and a rest mass of 0.113428913(17) u, or 105.658389(34) MeV. RBO_relaxed.owl CHEBI:131927 biolink:NamedThing dicarboxylic acids and O-substituted derivatives A class of carbonyl compound encompassing dicarboxylic acids and any derivatives obtained by substitution of either one or both of the carboxy hydrogens. RBO_relaxed.owl CHEBI:36586 biolink:NamedThing carbonyl compound Any compound containing the carbonyl group, C=O. The term is commonly used in the restricted sense of aldehydes and ketones, although it actually includes carboxylic acids and derivatives. RBO_relaxed.owl CHEBI:17087 biolink:NamedThing ketone A compound in which a carbonyl group is bonded to two carbon atoms: R2C=O (neither R may be H). RBO_relaxed.owl CHEBI:33308 biolink:NamedThing carboxylic ester An ester of a carboxylic acid, R(1)C(=O)OR(2), where R(1) = H or organyl and R(2) = organyl. RBO_relaxed.owl CHEBI:33575 biolink:NamedThing carboxylic acid A carbon oxoacid acid carrying at least one -C(=O)OH group and having the structure RC(=O)OH, where R is any any monovalent functional group. Carboxylic acids are the most common type of organic acid. RBO_relaxed.owl CHEBI:132153 biolink:NamedThing hyaluronate A carbohydrate acid derivative anion obtained by deprotonation of the carboxy groups of hyaluronic acid; major species at pH 7.3. RBO_relaxed.owl CHEBI:61469 biolink:NamedThing polyanionic polymer A polymer, composed of polyanion macromolecules. RBO_relaxed.owl CHEBI:63551 biolink:NamedThing carbohydrate acid derivative anion A carboxylic acid anion resulting from the deprotonation of the carboxy group of a carbohydrate acid derivative. RBO_relaxed.owl CHEBI:136889 biolink:NamedThing 5beta steroid Any steroid that has beta-configuration at position 5. RBO_relaxed.owl CHEBI:35341 biolink:NamedThing steroid Any of naturally occurring compounds and synthetic analogues, based on the cyclopenta[a]phenanthrene carbon skeleton, partially or completely hydrogenated; there are usually methyl groups at C-10 and C-13, and often an alkyl group at C-17. By extension, one or more bond scissions, ring expansions and/or ring contractions of the skeleton may have occurred. Natural steroids are derived biogenetically from squalene which is a triterpene. RBO_relaxed.owl CHEBI:26764 biolink:NamedThing steroid hormone Any steroid that acts as hormone. RBO_relaxed.owl CHEBI:35350 biolink:NamedThing hydroxy steroid RBO_relaxed.owl CHEBI:35508 biolink:NamedThing steroid fundamental parent RBO_relaxed.owl CHEBI:36078 biolink:NamedThing cholanoid RBO_relaxed.owl CHEBI:47891 biolink:NamedThing steroid acid Any steroid substituted by at least one carboxy group. RBO_relaxed.owl CHEBI:137980 biolink:NamedThing metalloid atom An atom of an element that exhibits properties that are between those of metals and nonmetals, or that has a mixture of them. The term generally includes boron, silicon, germanium, arsenic, antimony, and tellurium, while carbon, aluminium, selenium, polonium, and astatine are less commonly included. RBO_relaxed.owl CHEBI:33250 biolink:NamedThing uncharged atom A chemical entity constituting the smallest component of an element having the chemical properties of the element. RBO_relaxed.owl CHEBI:25585 biolink:NamedThing nonmetal atom RBO_relaxed.owl CHEBI:33318 biolink:NamedThing main group element atom An atom belonging to one of the main groups (found in the s- and p- blocks) of the periodic table. RBO_relaxed.owl CHEBI:33521 biolink:NamedThing metal atom An atom of an element that exhibits typical metallic properties, being typically shiny, with high electrical and thermal conductivity. RBO_relaxed.owl CHEBI:33559 biolink:NamedThing s-block element atom RBO_relaxed.owl OBO:RBO_00000060 biolink:NamedThing radionuclide Isotopes that exhibit radioactivity and undergo radioactive decay. (From Grant & Hackh's Chemical Dictionary, 5th ed & McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed) RBO_relaxed.owl CHEBI:138103 biolink:NamedThing inorganic acid A Bronsted acid derived from one or more inorganic compounds. Inorganic acids (also known as mineral acids) form hydrons and conjugate base ions when dissolved in water. RBO_relaxed.owl CHEBI:39141 biolink:NamedThing Bronsted acid A molecular entity capable of donating a hydron to an acceptor (Bronsted base). RBO_relaxed.owl CHEBI:48356 biolink:NamedThing protic solvent A polar solvent that is capable of acting as a hydron (proton) donor. RBO_relaxed.owl CHEBI:138366 biolink:NamedThing bile acids Any member of a group of hydroxy steroids occuring in bile, where they are present as the sodium salts of their amides with glycine or taurine. In mammals bile acids almost invariably have 5beta-configuration, while in lower vertebrates, some bile acids, known as allo-bile acids, have 5alpha-configuration. RBO_relaxed.owl CHEBI:25384 biolink:NamedThing monocarboxylic acid An oxoacid containing a single carboxy group. RBO_relaxed.owl CHEBI:15366 biolink:NamedThing acetic acid A simple monocarboxylic acid containing two carbons. RBO_relaxed.owl CHEBI:22868 biolink:NamedThing bile salt A sodium salt of the conjugate of any bile acid with either glycine or taurine. RBO_relaxed.owl CHEBI:36277 biolink:NamedThing bile acid salt A salt of a bile acid. RBO_relaxed.owl CHEBI:36278 biolink:NamedThing cholanic acids RBO_relaxed.owl CHEBI:138675 biolink:NamedThing gas molecular entity Any main group molecular entity that is gaseous at standard temperature and pressure (STP; 0degreeC and 100 kPa). RBO_relaxed.owl CHEBI:33579 biolink:NamedThing main group molecular entity A molecular entity containing one or more atoms from any of groups 1, 2, 13, 14, 15, 16, 17, and 18 of the periodic table. RBO_relaxed.owl CHEBI:33583 biolink:NamedThing noble gas molecular entity A main group molecular entity containing one or more atoms of any noble gas. RBO_relaxed.owl CHEBI:33674 biolink:NamedThing s-block molecular entity An s-block molecular entity is a molecular entity containing one or more atoms of an s-block element. RBO_relaxed.owl CHEBI:33675 biolink:NamedThing p-block molecular entity A main group molecular entity that contains one or more atoms of a p-block element. RBO_relaxed.owl CHEBI:13941 biolink:NamedThing carbamate RBO_relaxed.owl CHEBI:37022 biolink:NamedThing amino-acid anion RBO_relaxed.owl CHEBI:33558 biolink:NamedThing alpha-amino-acid anion An amino-acid anion obtained by deprotonation of any alpha-amino acid. RBO_relaxed.owl CHEBI:142163 biolink:NamedThing 24G7 epitope An antigenic epitope recognized by an anti-bilirubin monoclonal antibody designated 24G7. A substructure of bilirubin IXalpha, it is the region containing the oxo group at C-1, the methyl group at C-2, C-(4, 5, 6, 9), and N-21 and -22. RBO_relaxed.owl CHEBI:24433 biolink:NamedThing group A defined linked collection of atoms or a single atom within a molecular entity. RBO_relaxed.owl CHEBI:33246 biolink:NamedThing inorganic group Any substituent group which does not contain carbon. RBO_relaxed.owl CHEBI:33247 biolink:NamedThing organic group Any substituent group or skeleton containing carbon. RBO_relaxed.owl CHEBI:15022 biolink:NamedThing electron donor RBO_relaxed.owl CHEBI:17891 biolink:NamedThing donor A molecular entity that can transfer ("donate") an electron, a pair of electrons, an atom or a group to another molecular entity. RBO_relaxed.owl CHEBI:39144 biolink:NamedThing Lewis base A molecular entity able to provide a pair of electrons and thus capable of forming a covalent bond with an electron-pair acceptor (Lewis acid), thereby producing a Lewis adduct. RBO_relaxed.owl CHEBI:15339 biolink:NamedThing acceptor A molecular entity that can accept an electron, a pair of electrons, an atom or a group from another molecular entity. RBO_relaxed.owl CHEBI:22586 biolink:NamedThing antioxidant A substance that opposes oxidation or inhibits reactions brought about by dioxygen or peroxides. RBO_relaxed.owl CHEBI:22695 biolink:NamedThing base A molecular entity having an available pair of electrons capable of forming a covalent bond with a hydron (Bronsted base) or with the vacant orbital of some other molecular entity (Lewis base). RBO_relaxed.owl CHEBI:228364 biolink:NamedThing NMR chemical shift reference compound Any compound that produces a peak used to reference an NMR spectrum during data pre-processing. RBO_relaxed.owl CHEBI:35223 biolink:NamedThing catalyst A substance that increases the rate of a reaction without modifying the overall standard Gibbs energy change in the reaction. RBO_relaxed.owl CHEBI:37527 biolink:NamedThing acid An acid is a molecular entity capable of donating a hydron (Bronsted acid) or capable of forming a covalent bond with an electron pair (Lewis acid). RBO_relaxed.owl CHEBI:46787 biolink:NamedThing solvent A liquid that can dissolve other substances (solutes) without any change in their chemical composition. RBO_relaxed.owl CHEBI:63248 biolink:NamedThing oxidising agent A substance that removes electrons from another reactant in a redox reaction. RBO_relaxed.owl CHEBI:76413 biolink:NamedThing greenhouse gas RBO_relaxed.owl CHEBI:78298 biolink:NamedThing environmental contaminant RBO_relaxed.owl CHEBI:15355 biolink:NamedThing acetylcholine Actylcholine is an ester of acetic acid and choline, which acts as a neurotransmitter. RBO_relaxed.owl CHEBI:35287 biolink:NamedThing acylcholine A choline ester formed from choline and a carboxylic acid. RBO_relaxed.owl CHEBI:47622 biolink:NamedThing acetate ester Any carboxylic ester where the carboxylic acid component is acetic acid. RBO_relaxed.owl CHEBI:15377 biolink:NamedThing water RBO_relaxed.owl CHEBI:33693 biolink:NamedThing oxygen hydride RBO_relaxed.owl CHEBI:29793 biolink:NamedThing hydridodioxygen(1+) RBO_relaxed.owl CHEBI:37176 biolink:NamedThing mononuclear parent hydride RBO_relaxed.owl CHEBI:16134 biolink:NamedThing ammonia An azane that consists of a single nitrogen atom covelently bonded to three hydrogen atoms. RBO_relaxed.owl CHEBI:52625 biolink:NamedThing inorganic hydroxy compound RBO_relaxed.owl CHEBI:15378 biolink:NamedThing hydron The general name for the hydrogen nucleus, to be used without regard to the hydrogen nuclear mass (either for hydrogen in its natural abundance or where it is not desired to distinguish between the isotopes). RBO_relaxed.owl CHEBI:25414 biolink:NamedThing monoatomic monocation RBO_relaxed.owl CHEBI:29101 biolink:NamedThing sodium(1+) A monoatomic monocation obtained from sodium. RBO_relaxed.owl CHEBI:33251 biolink:NamedThing monoatomic hydrogen RBO_relaxed.owl CHEBI:33252 biolink:NamedThing atomic nucleus A nucleus is the positively charged central portion of an atom, excluding the orbital electrons. RBO_relaxed.owl CHEBI:30216 biolink:NamedThing alpha-particle Nucleus of the (4)He atom. RBO_relaxed.owl OBO:RBO_00000010 biolink:NamedThing light ion An atomic nucleus, fully stripped of its orbital electrons, and containing 2, 3, 4, 5, or 6 protons. RBO_relaxed.owl OBO:RBO_010012 biolink:NamedThing heavy ion An atomic nucleus, fully stripped of its orbital electrons, containing 2 or more protons. Nuclei containing between 2 protons (helium) and 6 protons (carbon) are sometimes referred to as light ions. RBO_relaxed.owl CHEBI:60242 biolink:NamedThing monovalent inorganic cation An atom or small molecule with a positive charge that does not contain carbon in covalent linkage, with a valency of one. RBO_relaxed.owl CHEBI:28938 biolink:NamedThing ammonium An onium cation obtained by protonation of ammonia. RBO_relaxed.owl CHEBI:15379 biolink:NamedThing dioxygen RBO_relaxed.owl CHEBI:16526 biolink:NamedThing carbon dioxide RBO_relaxed.owl CHEBI:17997 biolink:NamedThing dinitrogen RBO_relaxed.owl CHEBI:33309 biolink:NamedThing noble gas atom RBO_relaxed.owl CHEBI:25362 biolink:NamedThing elemental molecule A molecule all atoms of which have the same atomic number. RBO_relaxed.owl CHEBI:33263 biolink:NamedThing diatomic oxygen RBO_relaxed.owl CHEBI:155827 biolink:NamedThing argon-39 atom A trace radioisotope of argon with atomic mass of 38.964313 and a half-life of 269 years. RBO_relaxed.owl CHEBI:49475 biolink:NamedThing argon atom RBO_relaxed.owl CHEBI:15693 biolink:NamedThing aldose Aldehydic parent sugars (polyhydroxy aldehydes H[CH(OH)]nC(=O)H, n >= 2) and their intramolecular hemiacetals. RBO_relaxed.owl CHEBI:35381 biolink:NamedThing monosaccharide Parent monosaccharides are polyhydroxy aldehydes H[CH(OH)]nC(=O)H or polyhydroxy ketones H-[CHOH]n-C(=O)[CHOH]m-H with three or more carbon atoms. The generic term 'monosaccharide' (as opposed to oligosaccharide or polysaccharide) denotes a single unit, without glycosidic connection to other such units. It includes aldoses, dialdoses, aldoketoses, ketoses and diketoses, as well as deoxy sugars, provided that the parent compound has a (potential) carbonyl group. RBO_relaxed.owl CHEBI:18133 biolink:NamedThing hexose Any six-carbon monosaccharide which in its linear form contains either an aldehyde group at position 1 (aldohexose) or a ketone group at position 2 (ketohexose). RBO_relaxed.owl CHEBI:15841 biolink:NamedThing polypeptide A peptide containing ten or more amino acid residues. RBO_relaxed.owl CHEBI:16670 biolink:NamedThing peptide Amide derived from two or more amino carboxylic acid molecules (the same or different) by formation of a covalent bond from the carbonyl carbon of one to the nitrogen atom of another with formal loss of water. The term is usually applied to structures formed from alpha-amino acids, but it includes those derived from any amino carboxylic acid. X = OH, OR, NH2, NHR, etc. RBO_relaxed.owl CHEBI:23449 biolink:NamedThing cyclic peptide RBO_relaxed.owl CHEBI:25905 biolink:NamedThing peptide hormone Any peptide with hormonal activity in animals, whether endocrine, neuroendocrine, or paracrine. RBO_relaxed.owl CHEBI:33839 biolink:NamedThing macromolecule A macromolecule is a molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. RBO_relaxed.owl CHEBI:33694 biolink:NamedThing biomacromolecule A macromolecule formed by a living organism. RBO_relaxed.owl CHEBI:53368 biolink:NamedThing ionic macromolecule A macromolecule containing ionic groups. RBO_relaxed.owl CHEBI:15986 biolink:NamedThing polynucleotide A nucleobase-containing molecular entity with a polymeric structure comprised of a linear sequence of 13 or more nucleotide residues. RBO_relaxed.owl CHEBI:33695 biolink:NamedThing information biomacromolecule RBO_relaxed.owl CHEBI:61120 biolink:NamedThing nucleobase-containing molecular entity Any compound that has a nucleobase as a part. RBO_relaxed.owl CHEBI:35107 biolink:NamedThing azane Saturated acyclic nitrogen hydrides having the general formula NnHn+2. RBO_relaxed.owl CHEBI:16189 biolink:NamedThing sulfate A sulfur oxoanion obtained by deprotonation of both OH groups of sulfuric acid. RBO_relaxed.owl CHEBI:33482 biolink:NamedThing sulfur oxoanion RBO_relaxed.owl CHEBI:45696 biolink:NamedThing hydrogensulfate RBO_relaxed.owl CHEBI:58958 biolink:NamedThing organosulfate oxoanion An organic anion of general formula RS(=O)2O(-) where R is an organyl group. RBO_relaxed.owl CHEBI:48154 biolink:NamedThing sulfur oxide RBO_relaxed.owl CHEBI:79388 biolink:NamedThing divalent inorganic anion Any inorganic anion with a valency of two. RBO_relaxed.owl CHEBI:29340 biolink:NamedThing hydridonitrate(2-) A divalent inorganic anion resulting from the removal of two protons from ammonia. RBO_relaxed.owl CHEBI:43474 biolink:NamedThing hydrogenphosphate A phosphate ion that is the conjugate base of dihydrogenphosphate. RBO_relaxed.owl CHEBI:16336 biolink:NamedThing hyaluronic acid A mucopolysaccharide composed of N-acetylglucosamine and glucuronic acid subunits. It is found in the connective tissues of vertebrates. A principal constituent of the extracellular matrix (ECM), it mediates the growth and metastasis of tumour cells. RBO_relaxed.owl CHEBI:37395 biolink:NamedThing mucopolysaccharide Any of the group of polysaccharides composed of alternating units from uronic acids and glycosamines, and commonly partially esterified with sulfuric acid. RBO_relaxed.owl CHEBI:72813 biolink:NamedThing exopolysaccharide A biomacromolecule composed of carbohydrate residues which is secreted by a microorganism into the surrounding environment. RBO_relaxed.owl CHEBI:23014 biolink:NamedThing carbon oxide RBO_relaxed.owl CHEBI:64708 biolink:NamedThing one-carbon compound An organic molecular entity containing a single carbon atom (C1). RBO_relaxed.owl CHEBI:28616 biolink:NamedThing carbamic acid A one-carbon compound that is ammonia in which one of the hydrogens is replaced by a carboxy group. Although carbamic acid derivatives are common, carbamic acid itself has never been synthesised. RBO_relaxed.owl CHEBI:16541 biolink:NamedThing protein polypeptide chain A naturally occurring polypeptide synthesized at the ribosome. RBO_relaxed.owl CHEBI:16646 biolink:NamedThing carbohydrate Any member of the class of organooxygen compounds that is a polyhydroxy-aldehyde or -ketone or a lactol resulting from their intramolecular condensation (monosaccharides); substances derived from these by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom; and polymeric products arising by intermolecular acetal formation between two or more such molecules (disaccharides, polysaccharides and oligosaccharides). Carbohydrates contain only carbon, hydrogen and oxygen atoms; prior to any oxidation or reduction, most have the empirical formula Cm(H2O)n. Compounds obtained from carbohydrates by substitution, etc., are known as carbohydrate derivatives and may contain other elements. Cyclitols are generally not regarded as carbohydrates. RBO_relaxed.owl CHEBI:78616 biolink:NamedThing carbohydrates and carbohydrate derivatives Any organooxygen compound that is a polyhydroxy-aldehyde or -ketone, or a compound derived from one. Carbohydrates contain only carbon, hydrogen and oxygen and usually have an empirical formula Cm(H2O)n; carbohydrate derivatives may contain other elements by substitution or condensation. RBO_relaxed.owl CHEBI:167559 biolink:NamedThing glycan Any oligosaccharide, polysaccharide or their derivatives consisting of monosaccharides or monosaccharide derivatives linked by glycosidic bonds. See also http://www.ontobee.org/ontology/GNO?iri=http://purl.obolibrary.org/obo/GNO_00000001. RBO_relaxed.owl CHEBI:63299 biolink:NamedThing carbohydrate derivative Any organooxygen compound derived from a carbohydrate by replacement of one or more hydroxy group(s) by an amino group, a thiol group or similar heteroatomic groups. The term also includes derivatives of these compounds. RBO_relaxed.owl CHEBI:37622 biolink:NamedThing carboxamide An amide of a carboxylic acid, having the structure RC(=O)NR2. The term is used as a suffix in systematic name formation to denote the -C(=O)NH2 group including its carbon atom. RBO_relaxed.owl CHEBI:50047 biolink:NamedThing organic amino compound A compound formally derived from ammonia by replacing one, two or three hydrogen atoms by organyl groups. RBO_relaxed.owl CHEBI:32952 biolink:NamedThing amine A compound formally derived from ammonia by replacing one, two or three hydrogen atoms by hydrocarbyl groups. RBO_relaxed.owl CHEBI:33709 biolink:NamedThing amino acid A carboxylic acid containing one or more amino groups. RBO_relaxed.owl CHEBI:50994 biolink:NamedThing primary amino compound A compound formally derived from ammonia by replacing one hydrogen atom by an organyl group. RBO_relaxed.owl CHEBI:64365 biolink:NamedThing aralkylamino compound An organic amino compound in which an aminoalkyl group is linked to an arene. RBO_relaxed.owl PR:000018263 biolink:NamedThing amino acid chain An organic amino compound that consists of amino acid residues (unmodified amino-acid residues and/or modified amino-acid residues) linked by peptide bonds or derivatives of such bonds. RBO_relaxed.owl CHEBI:166902 biolink:NamedThing noradrenaline(1+) RBO_relaxed.owl CHEBI:25697 biolink:NamedThing organic cation Any organic ion with a net positive charge. RBO_relaxed.owl CHEBI:35267 biolink:NamedThing quaternary ammonium ion A derivative of ammonium, NH4(+), in which all four of the hydrogens bonded to nitrogen have been replaced with univalent (usually organyl) groups. RBO_relaxed.owl CHEBI:65296 biolink:NamedThing primary ammonium ion An ammonium ion derivative resulting from the protonation of the nitrogen atom of a primary amino compound. Major species at pH 7.3. RBO_relaxed.owl CHEBI:35274 biolink:NamedThing ammonium ion derivative A derivative of ammonium, NH4(+), in which one (or more) of the hydrogens bonded to the nitrogen have been replaced with univalent organyl groups. The substituting carbon of the organyl group must not itself be directly attached to a heteroatom (thereby excluding protonated amides, hemiaminals, etc). RBO_relaxed.owl CHEBI:350546 biolink:NamedThing serotonin(1+) An ammonium ion that is the conjugate acid of serotonin; major species at pH 7.3. RBO_relaxed.owl CHEBI:16765 biolink:NamedThing tryptamine An aminoalkylindole consisting of indole having a 2-aminoethyl group at the 3-position. RBO_relaxed.owl CHEBI:27162 biolink:NamedThing tryptamines Tryptamine and its substitution derivatives. RBO_relaxed.owl CHEBI:28790 biolink:NamedThing serotonin A primary amino compound that is the 5-hydroxy derivative of tryptamine. RBO_relaxed.owl CHEBI:38631 biolink:NamedThing aminoalkylindole RBO_relaxed.owl CHEBI:38958 biolink:NamedThing indole alkaloid An alkaloid containing an indole skeleton. RBO_relaxed.owl CHEBI:63534 biolink:NamedThing monoamine An aralylamino compound which contains one amino group connected to an aromatic ring by a two-carbon chain. Monoamines are derived from aromatic amino acids like phenylalanine, tyrosine, tryptophan, and the thyroid hormones by the action of aromatic amino acid decarboxylase enzymes. RBO_relaxed.owl CHEBI:16990 biolink:NamedThing bilirubin IXalpha A member of the class of biladienes that is a linear tetrapyrrole with the dipyrrole units being of both exovinyl and endovinyl type. A product of heme degradation, it is produced in the reticuloendothelial system by the reduction of biliverdin and transported to the liver as a complex with serum albumin. RBO_relaxed.owl CHEBI:35692 biolink:NamedThing dicarboxylic acid Any carboxylic acid containing two carboxy groups. RBO_relaxed.owl CHEBI:36735 biolink:NamedThing biladienes Compounds based on a biladiene skeleton. RBO_relaxed.owl CHEBI:16991 biolink:NamedThing deoxyribonucleic acid High molecular weight, linear polymers, composed of nucleotides containing deoxyribose and linked by phosphodiester bonds; DNA contain the genetic information of organisms. RBO_relaxed.owl CHEBI:33696 biolink:NamedThing nucleic acid A macromolecule made up of nucleotide units and hydrolysable into certain pyrimidine or purine bases (usually adenine, cytosine, guanine, thymine, uracil), D-ribose or 2-deoxy-D-ribose and phosphoric acid. RBO_relaxed.owl CHEBI:33697 biolink:NamedThing ribonucleic acid High molecular weight, linear polymers, composed of nucleotides containing ribose and linked by phosphodiester bonds; RNA is central to the synthesis of proteins. RBO_relaxed.owl CHEBI:17089 biolink:NamedThing glycoprotein A compound in which a carbohydrate component is covalently bound to a protein component. RBO_relaxed.owl CHEBI:33837 biolink:NamedThing conjugated protein Conjugated protein is a protein that contains a non-peptide component, usually in stoichiometric proportion. RBO_relaxed.owl CHEBI:35724 biolink:NamedThing carbohydrate sulfate RBO_relaxed.owl CHEBI:63436 biolink:NamedThing carbohydrate acid derivative A carbohydrate derivative that is formally obtained from a carbohydrate acid. RBO_relaxed.owl CHEBI:65212 biolink:NamedThing polysaccharide derivative A carbohydrate derivative that is any derivative of a polysaccharide. RBO_relaxed.owl CHEBI:17234 biolink:NamedThing glucose An aldohexose used as a source of energy and metabolic intermediate. RBO_relaxed.owl CHEBI:33917 biolink:NamedThing aldohexose A hexose with a (potential) aldehyde group at one end. RBO_relaxed.owl CHEBI:17544 biolink:NamedThing hydrogencarbonate The carbon oxoanion resulting from the removal of a proton from carbonic acid. RBO_relaxed.owl CHEBI:35604 biolink:NamedThing carbon oxoanion A negative ion consisting solely of carbon and oxygen atoms, and therefore having the general formula CxOy(n-) for some integers x, y and n. RBO_relaxed.owl CHEBI:41609 biolink:NamedThing carbonate RBO_relaxed.owl CHEBI:176566 biolink:NamedThing calcium-43 atom A minor stable isotope of calcium with relative atomic mass 42.95877 and 0.135 atom percent natural abundance. RBO_relaxed.owl CHEBI:22984 biolink:NamedThing calcium atom RBO_relaxed.owl CHEBI:176570 biolink:NamedThing molybdenum-98 atom A stable isotope of molybdenum with relative atomic mass 97.90541, 24.29 atom percent natural abundance and nuclear spin 0. RBO_relaxed.owl CHEBI:28685 biolink:NamedThing molybdenum atom RBO_relaxed.owl CHEBI:52633 biolink:NamedThing molybdenum-95 The stable isotope of molybdenum with relative atomic mass 94.905842, 15.9 atom percent natural abundance and nuclear spin 5/2. RBO_relaxed.owl CHEBI:176571 biolink:NamedThing strontium-88 atom A major stable isotope of strontium with relative atomic mass 87.90561 and 82.58 atom percent natural abundance. RBO_relaxed.owl CHEBI:33324 biolink:NamedThing strontium atom RBO_relaxed.owl CHEBI:176572 biolink:NamedThing rubidium-85 atom A stable isotope of rubidium with relative atomic mass 84.91179, 72.17 atom percent natural abundance and nuclear spin 5/2. RBO_relaxed.owl CHEBI:33322 biolink:NamedThing rubidium atom RBO_relaxed.owl CHEBI:52459 biolink:NamedThing rubidium-87 atom The stable isotope of rubidium with relative atomic mass 86.909184, 27.9 atom percent natural abundance and nuclear spin 3/2. RBO_relaxed.owl CHEBI:176573 biolink:NamedThing selenium-82 atom A stable isotope of selenium with relative atomic mass 81.91670, 8.82 atom percent natural abundance and nuclear spin 0. RBO_relaxed.owl CHEBI:27568 biolink:NamedThing selenium atom RBO_relaxed.owl CHEBI:52457 biolink:NamedThing selenium-77 atom A stable isotope of selenium with relative atomic mass 76.919915, 7.60 atom percent natural abundance and nuclear spin 1/2. RBO_relaxed.owl CHEBI:176574 biolink:NamedThing zinc-66 atom A stable isotope of zinc with relative atomic mass 65.92603, 27.7 atom percent natural abundance and nuclear spin 0. RBO_relaxed.owl CHEBI:27363 biolink:NamedThing zinc atom RBO_relaxed.owl CHEBI:82623 biolink:NamedThing zinc-65 atom A zinc atom in which the nucleus contains 35 neutrons. It has a half-life of 244 days, decaying by emission of a positron (beta(+) decay), and is the most abundant and stable of the 25 known radioisotopes of zinc. RBO_relaxed.owl CHEBI:176575 biolink:NamedThing nickel-60 atom A stable isotope of nickel with relative atomic mass 59.93079, 26.223 atom percent natural abundance and nuclear spin 0. RBO_relaxed.owl CHEBI:28112 biolink:NamedThing nickel atom Chemical element (nickel group element atom) with atomic number 28. RBO_relaxed.owl CHEBI:176578 biolink:NamedThing cobalt-59 atom A stable isotope of cobalt with relative atomic mass 58.93319, 100 atom percent natural abundance and nuclear spin 7/2. RBO_relaxed.owl CHEBI:27638 biolink:NamedThing cobalt atom A cobalt group element atom that has atomic number 27. RBO_relaxed.owl CHEBI:176583 biolink:NamedThing manganese-55 atom A stable isotope of manganese with relative atomic mass 54.93804, 100 atom percent natural abundance and nuclear spin 5/2. RBO_relaxed.owl CHEBI:18291 biolink:NamedThing manganese atom RBO_relaxed.owl CHEBI:176584 biolink:NamedThing arsenic-75 atom A stable isotope of arsenic with relative atomic mass 74.921596, 100 atom percent natural abundance and nuclear spin 3/2. RBO_relaxed.owl CHEBI:27563 biolink:NamedThing arsenic atom RBO_relaxed.owl CHEBI:33266 biolink:NamedThing diatomic nitrogen RBO_relaxed.owl CHEBI:18059 biolink:NamedThing lipid 'Lipids' is a loosely defined term for substances of biological origin that are soluble in nonpolar solvents. They consist of saponifiable lipids, such as glycerides (fats and oils) and phospholipids, as well as nonsaponifiable lipids, principally steroids. RBO_relaxed.owl CHEBI:50860 biolink:NamedThing organic molecular entity Any molecular entity that contains carbon. RBO_relaxed.owl CHEBI:25699 biolink:NamedThing organic ion RBO_relaxed.owl CHEBI:33245 biolink:NamedThing organic fundamental parent An organic fundamental parent is a structure used as a basis for substitutive names in organic nomenclature, containing, in addition to one or more hydrogen atoms, a single atom of an element, a number of atoms (alike or different) linked together to form an unbranched chain, a monocyclic or polycyclic ring system, or a ring assembly or ring/chain system. RBO_relaxed.owl CHEBI:33285 biolink:NamedThing heteroorganic entity A heteroorganic entity is an organic molecular entity in which carbon atoms or organic groups are bonded directly to one or more heteroatoms. RBO_relaxed.owl CHEBI:33822 biolink:NamedThing organic hydroxy compound An organic compound having at least one hydroxy group attached to a carbon atom. RBO_relaxed.owl CHEBI:64709 biolink:NamedThing organic acid Any organic molecular entity that is acidic and contains carbon in covalent linkage. RBO_relaxed.owl CHEBI:72695 biolink:NamedThing organic molecule Any molecule that consists of at least one carbon atom as part of the electrically neutral entity. RBO_relaxed.owl CHEBI:18085 biolink:NamedThing glycosaminoglycan Any polysaccharide containing a substantial proportion of aminomonosaccharide residues. RBO_relaxed.owl CHEBI:22506 biolink:NamedThing aminoglycan RBO_relaxed.owl CHEBI:18154 biolink:NamedThing polysaccharide A biomacromolecule consisting of large numbers of monosaccharide residues linked glycosidically. This term is commonly used only for those containing more than ten monosaccharide residues. RBO_relaxed.owl CHEBI:33720 biolink:NamedThing carbohydrate acid RBO_relaxed.owl CHEBI:18248 biolink:NamedThing iron atom An iron group element atom that has atomic number 26. RBO_relaxed.owl CHEBI:33356 biolink:NamedThing iron group element atom RBO_relaxed.owl CHEBI:30682 biolink:NamedThing ruthenium atom RBO_relaxed.owl CHEBI:30687 biolink:NamedThing osmium atom RBO_relaxed.owl CHEBI:33357 biolink:NamedThing hassium atom RBO_relaxed.owl CHEBI:18282 biolink:NamedThing nucleobase That part of DNA or RNA that may be involved in pairing. RBO_relaxed.owl CHEBI:38101 biolink:NamedThing organonitrogen heterocyclic compound Any organonitrogen compound containing a cyclic component with nitrogen and at least one other element as ring member atoms. RBO_relaxed.owl CHEBI:22728 biolink:NamedThing benzopyrrole RBO_relaxed.owl CHEBI:38077 biolink:NamedThing polypyrrole A compound composed of two or more pyrrole units. RBO_relaxed.owl CHEBI:33352 biolink:NamedThing manganese group element atom RBO_relaxed.owl CHEBI:33353 biolink:NamedThing technetium atom RBO_relaxed.owl CHEBI:33355 biolink:NamedThing bohrium atom RBO_relaxed.owl CHEBI:49882 biolink:NamedThing rhenium atom RBO_relaxed.owl CHEBI:18357 biolink:NamedThing (R)-noradrenaline The R-enantiomer of noradrenaline. RBO_relaxed.owl CHEBI:33569 biolink:NamedThing noradrenaline A catecholamine in which C-1 of the aminoethyl side-chain is hydroxy-substituted. RBO_relaxed.owl CHEBI:33571 biolink:NamedThing (S)-noradrenaline The S-enantiomer of noradrenaline. RBO_relaxed.owl CHEBI:18367 biolink:NamedThing phosphate(3-) A phosphate ion that is the conjugate base of hydrogenphosphate. RBO_relaxed.owl CHEBI:35780 biolink:NamedThing phosphate ion A phosphorus oxoanion that is the conjugate base of phosphoric acid. RBO_relaxed.owl CHEBI:39745 biolink:NamedThing dihydrogenphosphate A monovalent inorganic anion that consists of phosphoric acid in which one of the three OH groups has been deprotonated. RBO_relaxed.owl CHEBI:79387 biolink:NamedThing trivalent inorganic anion Any inorganic anion with a valency of three. RBO_relaxed.owl CHEBI:194531 biolink:NamedThing flerovium atom A carbon group element atom with a symbol Fl and atomic number 114. RBO_relaxed.owl CHEBI:33306 biolink:NamedThing carbon group element atom RBO_relaxed.owl CHEBI:25016 biolink:NamedThing lead atom RBO_relaxed.owl CHEBI:27007 biolink:NamedThing tin atom RBO_relaxed.owl CHEBI:27573 biolink:NamedThing silicon atom RBO_relaxed.owl CHEBI:27594 biolink:NamedThing carbon atom RBO_relaxed.owl CHEBI:30441 biolink:NamedThing germanium atom RBO_relaxed.owl CHEBI:194533 biolink:NamedThing nihonium atom A boron group element atom with a symbol Nh and atomic number 113. RBO_relaxed.owl CHEBI:33317 biolink:NamedThing boron group element atom RBO_relaxed.owl CHEBI:27560 biolink:NamedThing boron atom RBO_relaxed.owl CHEBI:28984 biolink:NamedThing aluminium atom RBO_relaxed.owl CHEBI:30430 biolink:NamedThing indium atom A metallic element first identified and named from the brilliant indigo (Latin indicum) blue line in its flame spectrum. RBO_relaxed.owl CHEBI:30440 biolink:NamedThing thallium A metallic element first identified and named from the brilliant green line in its flame spectrum (from Greek thetaalphalambdalambdaomicronsigma, a green shoot). RBO_relaxed.owl CHEBI:49631 biolink:NamedThing gallium atom A metallic element predicted as eka-aluminium by Mendeleev in 1870 and discovered by Paul-Emile Lecoq de Boisbaudran in 1875. Named in honour of France (Latin Gallia) and perhaps also from the Latin gallus cock, a translation of Lecoq. RBO_relaxed.owl CHEBI:194535 biolink:NamedThing moscovium atom A pnictogen atom with a symbol Mc and atomic number 115. RBO_relaxed.owl CHEBI:33300 biolink:NamedThing pnictogen Any p-block element atom that is in group 15 of the periodic table: nitrogen, phosphorus, arsenic, antimony and bismuth. RBO_relaxed.owl CHEBI:25555 biolink:NamedThing nitrogen atom RBO_relaxed.owl CHEBI:28659 biolink:NamedThing phosphorus atom RBO_relaxed.owl CHEBI:30513 biolink:NamedThing antimony atom RBO_relaxed.owl CHEBI:33301 biolink:NamedThing bismuth atom RBO_relaxed.owl CHEBI:194537 biolink:NamedThing livermorium atom A chalcogen atom with a symbol Lv and atomic number 116. RBO_relaxed.owl CHEBI:33303 biolink:NamedThing chalcogen Any p-block element belonging to the group 16 family of the periodic table. RBO_relaxed.owl CHEBI:25805 biolink:NamedThing oxygen atom RBO_relaxed.owl CHEBI:26833 biolink:NamedThing sulfur atom RBO_relaxed.owl CHEBI:30452 biolink:NamedThing tellurium atom RBO_relaxed.owl CHEBI:33313 biolink:NamedThing polonium atom A radioactive metallic element discovered in 1898 by Marie Sklodowska Curie and named after her home country, Poland (Latin Polonia). RBO_relaxed.owl CHEBI:194539 biolink:NamedThing tennessine atom A halogen atom with a symbol Ts and atomic number 117. RBO_relaxed.owl CHEBI:24473 biolink:NamedThing halogen RBO_relaxed.owl CHEBI:22927 biolink:NamedThing bromine atom RBO_relaxed.owl CHEBI:23116 biolink:NamedThing chlorine atom RBO_relaxed.owl CHEBI:24061 biolink:NamedThing fluorine atom RBO_relaxed.owl CHEBI:24859 biolink:NamedThing iodine atom Chemical element with atomic number 53. RBO_relaxed.owl CHEBI:30415 biolink:NamedThing astatine atom RBO_relaxed.owl CHEBI:194541 biolink:NamedThing oganesson atom A p-block element atom with a symbol Og and atomic number 118. RBO_relaxed.owl CHEBI:30217 biolink:NamedThing helium atom RBO_relaxed.owl CHEBI:33310 biolink:NamedThing neon atom RBO_relaxed.owl CHEBI:33314 biolink:NamedThing radon atom RBO_relaxed.owl CHEBI:49696 biolink:NamedThing krypton atom RBO_relaxed.owl CHEBI:49957 biolink:NamedThing xenon atom RBO_relaxed.owl CHEBI:33560 biolink:NamedThing p-block element atom Any main group element atom belonging to the p-block of the periodic table. RBO_relaxed.owl CHEBI:20664 biolink:NamedThing 5beta-cholane RBO_relaxed.owl CHEBI:35519 biolink:NamedThing cholane RBO_relaxed.owl CHEBI:22221 biolink:NamedThing acyl group An organic group formed by removing one or more hydroxy groups from an oxoacid that has the general structure RkE(=O)l(OH)m (l =/= 0). Although the term is almost always applied to organic compounds, with carboxylic acid as the oxoacid, acyl groups can in principle be derived from other types of acids such as sulfonic acids or phosphonic acids. RBO_relaxed.owl CHEBI:33708 biolink:NamedThing amino-acid residue When two or more amino acids combine to form a peptide, the elements of water are removed, and what remains of each amino acid is called an amino-acid residue. RBO_relaxed.owl CHEBI:50319 biolink:NamedThing nucleotide residue RBO_relaxed.owl CHEBI:50320 biolink:NamedThing nucleoside residue RBO_relaxed.owl CHEBI:51446 biolink:NamedThing organic divalent group RBO_relaxed.owl CHEBI:51447 biolink:NamedThing organic univalent group RBO_relaxed.owl CHEBI:52845 biolink:NamedThing cyclic organic group An organic group that consists of a closed ring. It may be a substituent or a skeleton. RBO_relaxed.owl CHEBI:22313 biolink:NamedThing alkaline earth metal atom RBO_relaxed.owl CHEBI:22314 biolink:NamedThing alkali metal atom RBO_relaxed.owl CHEBI:27081 biolink:NamedThing transition element atom An element whose atom has an incomplete d sub-shell, or which can give rise to cations with an incomplete d sub-shell. RBO_relaxed.owl CHEBI:5631 biolink:NamedThing heavy metal Any metal that is characterized by its rather high atomic mass and density. Although typically occurring in low concentrations, they can be found all throughout the Earth's crust (Commonly, a density of at least 5 g cm(3) is used to define a heavy metal and to differentiate it from other, ''light'' metals). RBO_relaxed.owl CHEBI:88184 biolink:NamedThing metal allergen Any metal which causes the onset of an allergic reaction. RBO_relaxed.owl CHEBI:49637 biolink:NamedThing hydrogen atom RBO_relaxed.owl CHEBI:22315 biolink:NamedThing alkaloid Any of the naturally occurring, basic nitrogen compounds (mostly heterocyclic) occurring mostly in the plant kingdom, but also found in bacteria, fungi, and animals. By extension, certain neutral compounds biogenetically related to basic alkaloids are also classed as alkaloids. Amino acids, peptides, proteins, nucleotides, nucleic acids, amino sugars and antibiotics are not normally regarded as alkaloids. Compounds in which the nitrogen is exocyclic (dopamine, mescaline, serotonin, etc.) are usually classed as amines rather than alkaloids. RBO_relaxed.owl CHEBI:35352 biolink:NamedThing organonitrogen compound Any heteroorganic entity containing at least one carbon-nitrogen bond. RBO_relaxed.owl CHEBI:22563 biolink:NamedThing anion A monoatomic or polyatomic species having one or more elementary charges of the electron. RBO_relaxed.owl CHEBI:24870 biolink:NamedThing ion A molecular entity having a net electric charge. RBO_relaxed.owl CHEBI:24867 biolink:NamedThing monoatomic ion RBO_relaxed.owl CHEBI:36358 biolink:NamedThing polyatomic ion An ion consisting of more than one atom. RBO_relaxed.owl CHEBI:36914 biolink:NamedThing inorganic ion RBO_relaxed.owl CHEBI:36916 biolink:NamedThing cation A monoatomic or polyatomic species having one or more elementary charges of the proton. RBO_relaxed.owl CHEBI:27171 biolink:NamedThing organic heterobicyclic compound RBO_relaxed.owl CHEBI:38180 biolink:NamedThing polycyclic heteroarene RBO_relaxed.owl CHEBI:33286 biolink:NamedThing agrochemical An agrochemical is a substance that is used in agriculture or horticulture. RBO_relaxed.owl CHEBI:33292 biolink:NamedThing fuel RBO_relaxed.owl CHEBI:33893 biolink:NamedThing reagent A substance used in a chemical reaction to detect, measure, examine, or produce other substances. RBO_relaxed.owl CHEBI:52217 biolink:NamedThing pharmaceutical Any substance introduced into a living organism with therapeutic or diagnostic purpose. RBO_relaxed.owl CHEBI:64047 biolink:NamedThing food additive Any substance which is added to food to preserve or enhance its flavour and/or appearance. RBO_relaxed.owl CHEBI:67079 biolink:NamedThing anti-inflammatory agent Any compound that has anti-inflammatory effects. RBO_relaxed.owl CHEBI:78433 biolink:NamedThing refrigerant A substance used in a thermodynamic heat pump cycle or refrigeration cycle that undergoes a phase change from a gas to a liquid and back. Refrigerants are used in air-conditioning systems and freezers or refrigerators and are assigned a "R" number (by ASHRAE - formerly the American Society of Heating, Refrigerating and Air Conditioning Engineers), which is determined systematically according to their molecular structure. RBO_relaxed.owl CHEBI:38700 biolink:NamedThing organic sodium salt RBO_relaxed.owl CHEBI:22977 biolink:NamedThing cadmium atom RBO_relaxed.owl CHEBI:33340 biolink:NamedThing zinc group element atom RBO_relaxed.owl CHEBI:25195 biolink:NamedThing mercury atom RBO_relaxed.owl CHEBI:33517 biolink:NamedThing copernicium atom A zinc group element atom with a symbol Cn and atomic number 112. All its isotopes are intensely radioactive. Prior to its discovery, it had the placeholder name ununbium (in accordance with IUPAC recommendations). Following its discovery (in Darmstadt, 1996) and subsequent confirmation, the name copernicium was adopted in 2010. RBO_relaxed.owl CHEBI:25107 biolink:NamedThing magnesium atom RBO_relaxed.owl CHEBI:30501 biolink:NamedThing beryllium atom Alkaline earth metal atom with atomic number 4. RBO_relaxed.owl CHEBI:32594 biolink:NamedThing barium atom RBO_relaxed.owl CHEBI:33325 biolink:NamedThing radium atom RBO_relaxed.owl CHEBI:23004 biolink:NamedThing carbamoyl group The univalent carboacyl group formed by loss of -OH from the carboxy group of carbamic acid. RBO_relaxed.owl CHEBI:27207 biolink:NamedThing univalent carboacyl group A univalent carboacyl group is a group formed by loss of OH from the carboxy group of a carboxylic acid. RBO_relaxed.owl CHEBI:25701 biolink:NamedThing organic oxide RBO_relaxed.owl CHEBI:36963 biolink:NamedThing organooxygen compound An organochalcogen compound containing at least one carbon-oxygen bond. RBO_relaxed.owl CHEBI:35605 biolink:NamedThing carbon oxoacid RBO_relaxed.owl CHEBI:35701 biolink:NamedThing ester A compound formally derived from an oxoacid RkE(=O)l(OH)m (l > 0) and an alcohol, phenol, heteroarenol, or enol by linking with formal loss of water from an acidic hydroxy group of the former and a hydroxy group of the latter. RBO_relaxed.owl CHEBI:23019 biolink:NamedThing carbonyl group RBO_relaxed.owl CHEBI:51422 biolink:NamedThing organodiyl group Any organic substituent group, regardless of functional type, having two free valences at carbon atom(s). RBO_relaxed.owl CHEBI:23114 biolink:NamedThing chloride salt RBO_relaxed.owl CHEBI:23117 biolink:NamedThing chlorine molecular entity RBO_relaxed.owl CHEBI:33958 biolink:NamedThing halide salt RBO_relaxed.owl CHEBI:24471 biolink:NamedThing halogen molecular entity RBO_relaxed.owl CHEBI:37578 biolink:NamedThing halide RBO_relaxed.owl CHEBI:23357 biolink:NamedThing cofactor An organic molecule or ion (usually a metal ion) that is required by an enzyme for its activity. It may be attached either loosely (coenzyme) or tightly (prosthetic group). RBO_relaxed.owl CHEBI:52206 biolink:NamedThing biochemical role A biological role played by the molecular entity or part thereof within a biochemical context. RBO_relaxed.owl CHEBI:23924 biolink:NamedThing enzyme inhibitor A compound or agent that combines with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction. RBO_relaxed.owl CHEBI:25212 biolink:NamedThing metabolite Any intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites. RBO_relaxed.owl CHEBI:23367 biolink:NamedThing molecular entity Any constitutionally or isotopically distinct atom, molecule, ion, ion pair, radical, radical ion, complex, conformer etc., identifiable as a separately distinguishable entity. RBO_relaxed.owl CHEBI:59999 biolink:NamedThing chemical substance A chemical substance is a portion of matter of constant composition, composed of molecular entities of the same type or of different types. RBO_relaxed.owl CHEBI:23888 biolink:NamedThing drug Any substance which when absorbed into a living organism may modify one or more of its functions. The term is generally accepted for a substance taken for a therapeutic purpose, but is also commonly used for abused substances. RBO_relaxed.owl CHEBI:23906 biolink:NamedThing monoatomic cation RBO_relaxed.owl CHEBI:33702 biolink:NamedThing polyatomic cation A cation consisting of more than one atom. RBO_relaxed.owl CHEBI:36915 biolink:NamedThing inorganic cation RBO_relaxed.owl CHEBI:35222 biolink:NamedThing inhibitor A substance that diminishes the rate of a chemical reaction. RBO_relaxed.owl CHEBI:24384 biolink:NamedThing glycogens RBO_relaxed.owl CHEBI:37163 biolink:NamedThing glucan A polysaccharide composed of glucose residues. RBO_relaxed.owl CHEBI:33302 biolink:NamedThing pnictogen molecular entity A p-block molecular entity containing any pnictogen. RBO_relaxed.owl CHEBI:33304 biolink:NamedThing chalcogen molecular entity Any p-block molecular entity containing a chalcogen. RBO_relaxed.owl CHEBI:33582 biolink:NamedThing carbon group molecular entity RBO_relaxed.owl CHEBI:24532 biolink:NamedThing organic heterocyclic compound A cyclic compound having as ring members atoms of carbon and at least of one other element. RBO_relaxed.owl CHEBI:36962 biolink:NamedThing organochalcogen compound An organochalcogen compound is a compound containing at least one carbon-chalcogen bond. RBO_relaxed.owl CHEBI:33832 biolink:NamedThing organic cyclic compound Any organic molecule that consists of atoms connected in the form of a ring. RBO_relaxed.owl CHEBI:33659 biolink:NamedThing organic aromatic compound RBO_relaxed.owl CHEBI:51958 biolink:NamedThing organic polycyclic compound RBO_relaxed.owl CHEBI:5686 biolink:NamedThing heterocyclic compound A cyclic compound having as ring members atoms of at least two different elements. RBO_relaxed.owl CHEBI:33671 biolink:NamedThing heteropolycyclic compound A polycyclic compound in which at least one of the rings contains at least one non-carbon atom. RBO_relaxed.owl CHEBI:33672 biolink:NamedThing heterobicyclic compound A bicyclic compound in which at least one of the rings contains at least one skeletal heteroatom. RBO_relaxed.owl CHEBI:24533 biolink:NamedThing heterodetic cyclic peptide A heterodetic cyclic peptide is a peptide consisting only of amino-acid residues, but in which the linkages forming the ring are not solely peptide bonds; one or more is an isopeptide, disulfide, ester, or other bond. RBO_relaxed.owl CHEBI:24621 biolink:NamedThing hormone Originally referring to an endogenous compound that is formed in specialized organ or group of cells and carried to another organ or group of cells, in the same organism, upon which it has a specific regulatory function, the term is now commonly used to include non-endogenous, semi-synthetic and fully synthetic analogues of such compounds. RBO_relaxed.owl CHEBI:33280 biolink:NamedThing molecular messenger RBO_relaxed.owl CHEBI:25512 biolink:NamedThing neurotransmitter An endogenous compound that is used to transmit information across the synapse between a neuron and another cell. RBO_relaxed.owl CHEBI:48705 biolink:NamedThing agonist Substance which binds to cell receptors normally responding to naturally occurring substances and which produces a response of its own. RBO_relaxed.owl CHEBI:24636 biolink:NamedThing proton Nuclear particle of charge number +1, spin 1/2 and rest mass of 1.007276470(12) u. RBO_relaxed.owl CHEBI:33253 biolink:NamedThing nucleon Heavy nuclear particle: proton or neutron. RBO_relaxed.owl CHEBI:30222 biolink:NamedThing neutron Nuclear particle of zero charge, spin 1/2 and rest mass of 1.008664904(14) u. RBO_relaxed.owl CHEBI:24651 biolink:NamedThing hydroxides Hydroxides are chemical compounds containing a hydroxy group or salts containing hydroxide (OH(-)). RBO_relaxed.owl CHEBI:25806 biolink:NamedThing oxygen molecular entity RBO_relaxed.owl CHEBI:25741 biolink:NamedThing oxide An oxide is a chemical compound of oxygen with other chemical elements. RBO_relaxed.owl CHEBI:33262 biolink:NamedThing elemental oxygen RBO_relaxed.owl CHEBI:33608 biolink:NamedThing hydrogen molecular entity RBO_relaxed.owl CHEBI:33260 biolink:NamedThing elemental hydrogen RBO_relaxed.owl CHEBI:33692 biolink:NamedThing hydrides Hydrides are chemical compounds of hydrogen with other chemical elements. RBO_relaxed.owl CHEBI:37577 biolink:NamedThing heteroatomic molecular entity A molecular entity consisting of two or more chemical elements. RBO_relaxed.owl CHEBI:24866 biolink:NamedThing salt A salt is an assembly of cations and anions. RBO_relaxed.owl CHEBI:33241 biolink:NamedThing oxoacid derivative RBO_relaxed.owl CHEBI:50312 biolink:NamedThing onium compound RBO_relaxed.owl CHEBI:24663 biolink:NamedThing hydroxy-5beta-cholanic acid Any member of the class of 5beta-cholanic acids carrying at least one hydroxy group at unspecified position. RBO_relaxed.owl CHEBI:33853 biolink:NamedThing phenols Organic aromatic compounds having one or more hydroxy groups attached to a benzene or other arene ring. RBO_relaxed.owl CHEBI:84729 biolink:NamedThing hydroxyindoles Any member of the class of indoles carrying at least one hydroxy group. RBO_relaxed.owl CHEBI:36248 biolink:NamedThing 5beta-cholanic acids Members of the class of cholanic acids based on a 5beta-cholane skeleton. RBO_relaxed.owl CHEBI:36238 biolink:NamedThing 5beta-cholanic acid RBO_relaxed.owl CHEBI:24828 biolink:NamedThing indoles Any compound containing an indole skeleton. RBO_relaxed.owl CHEBI:24833 biolink:NamedThing oxoacid A compound which contains oxygen, at least one other element, and at least one hydrogen bound to oxygen, and which produces a conjugate base by loss of positive hydrogen ion(s) (hydrons). RBO_relaxed.owl CHEBI:24834 biolink:NamedThing inorganic anion RBO_relaxed.owl CHEBI:25696 biolink:NamedThing organic anion Any organic ion with a net negative charge. RBO_relaxed.owl CHEBI:33273 biolink:NamedThing polyatomic anion An anion consisting of more than one atom. RBO_relaxed.owl CHEBI:24835 biolink:NamedThing inorganic molecular entity A molecular entity that contains no carbon. RBO_relaxed.owl CHEBI:33259 biolink:NamedThing elemental molecular entity A molecular entity all atoms of which have the same atomic number. RBO_relaxed.owl CHEBI:33497 biolink:NamedThing transition element molecular entity A molecular entity containing one or more atoms of a transition element. RBO_relaxed.owl CHEBI:36357 biolink:NamedThing polyatomic entity Any molecular entity consisting of more than one atom. RBO_relaxed.owl CHEBI:24836 biolink:NamedThing inorganic oxide RBO_relaxed.owl CHEBI:24839 biolink:NamedThing inorganic salt RBO_relaxed.owl CHEBI:33242 biolink:NamedThing inorganic hydride RBO_relaxed.owl CHEBI:33465 biolink:NamedThing elemental pnictogen RBO_relaxed.owl CHEBI:35406 biolink:NamedThing oxoanion An oxoanion is an anion derived from an oxoacid by loss of hydron(s) bound to oxygen. RBO_relaxed.owl CHEBI:24868 biolink:NamedThing organic salt RBO_relaxed.owl CHEBI:35479 biolink:NamedThing alkali metal salt RBO_relaxed.owl CHEBI:33238 biolink:NamedThing monoatomic entity A monoatomic entity is a molecular entity consisting of a single atom. RBO_relaxed.owl CHEBI:33315 biolink:NamedThing monoatomic helium RBO_relaxed.owl CHEBI:24873 biolink:NamedThing iron molecular entity RBO_relaxed.owl CHEBI:33744 biolink:NamedThing iron group molecular entity RBO_relaxed.owl CHEBI:25046 biolink:NamedThing linear tetrapyrrole RBO_relaxed.owl CHEBI:26932 biolink:NamedThing tetrapyrrole A natural pigment containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next. RBO_relaxed.owl CHEBI:25213 biolink:NamedThing metal cation RBO_relaxed.owl CHEBI:30412 biolink:NamedThing monoatomic dication RBO_relaxed.owl CHEBI:25367 biolink:NamedThing molecule Any polyatomic entity that is an electrically neutral entity consisting of more than one atom. RBO_relaxed.owl CHEBI:33595 biolink:NamedThing cyclic compound Any molecule that consists of a series of atoms joined together to form a ring. RBO_relaxed.owl CHEBI:25375 biolink:NamedThing monoamine molecular messenger A group of neurotransmitters and neuromodulators that contain one amino group that is connected to an aromatic ring by ethylene group (-CH2-CH2-). Monoamines are derived from the aromatic amino acids phenylalanine, tyrosine, histidine and tryptophan. RBO_relaxed.owl CHEBI:36587 biolink:NamedThing organic oxo compound Organic compounds containing an oxygen atom, =O, doubly bonded to carbon or another element. RBO_relaxed.owl CHEBI:51151 biolink:NamedThing dipolar compound An organic molecule that is electrically neutral carrying a positive and a negative charge in one of its major canonical descriptions. In most dipolar compounds the charges are delocalized; however the term is also applied to species where this is not the case. RBO_relaxed.owl CHEBI:25704 biolink:NamedThing organic sulfate Compounds of the general formula SO3HOR where R is an organyl group RBO_relaxed.owl CHEBI:26820 biolink:NamedThing sulfates Salts and esters of sulfuric acid RBO_relaxed.owl CHEBI:26835 biolink:NamedThing sulfur molecular entity RBO_relaxed.owl CHEBI:36902 biolink:NamedThing chalcogen hydride RBO_relaxed.owl CHEBI:26020 biolink:NamedThing phosphate Salts and esters of phosphoric and oligophosphoric acids and their chalcogen analogues. In inorganic chemistry, the term is also used to describe anionic coordination entities with phosphorus as central atom. RBO_relaxed.owl CHEBI:26079 biolink:NamedThing phosphoric acid derivative RBO_relaxed.owl CHEBI:26078 biolink:NamedThing phosphoric acid A phosphorus oxoacid that consists of one oxo and three hydroxy groups joined covalently to a central phosphorus atom. RBO_relaxed.owl CHEBI:59698 biolink:NamedThing phosphoric acids Compounds containing one or more phosphoric acid units. RBO_relaxed.owl CHEBI:36359 biolink:NamedThing phosphorus oxoacid derivative RBO_relaxed.owl CHEBI:26082 biolink:NamedThing phosphorus molecular entity RBO_relaxed.owl CHEBI:33408 biolink:NamedThing pnictogen oxoacid RBO_relaxed.owl CHEBI:33459 biolink:NamedThing pnictogen oxoanion RBO_relaxed.owl CHEBI:35881 biolink:NamedThing pnictogen hydride RBO_relaxed.owl CHEBI:51143 biolink:NamedThing nitrogen molecular entity RBO_relaxed.owl CHEBI:26216 biolink:NamedThing potassium atom RBO_relaxed.owl CHEBI:26708 biolink:NamedThing sodium atom RBO_relaxed.owl CHEBI:30145 biolink:NamedThing lithium atom RBO_relaxed.owl CHEBI:30514 biolink:NamedThing caesium atom RBO_relaxed.owl CHEBI:33323 biolink:NamedThing francium atom RBO_relaxed.owl CHEBI:26710 biolink:NamedThing sodium chloride RBO_relaxed.owl CHEBI:36093 biolink:NamedThing inorganic chloride RBO_relaxed.owl CHEBI:38702 biolink:NamedThing inorganic sodium salt RBO_relaxed.owl CHEBI:26712 biolink:NamedThing sodium molecular entity RBO_relaxed.owl CHEBI:33296 biolink:NamedThing alkali metal molecular entity A molecular entity containing one or more atoms of an alkali metal. RBO_relaxed.owl CHEBI:26714 biolink:NamedThing sodium salt Any alkali metal salt having sodium(1+) as the cation. RBO_relaxed.owl CHEBI:37246 biolink:NamedThing elemental sodium RBO_relaxed.owl CHEBI:26819 biolink:NamedThing sulfuric ester An ester of an alcohol and sulfuric acid. RBO_relaxed.owl CHEBI:37826 biolink:NamedThing sulfuric acid derivative RBO_relaxed.owl CHEBI:26836 biolink:NamedThing sulfuric acid A sulfur oxoacid that consists of two oxo and two hydroxy groups joined covalently to a central sulfur atom. RBO_relaxed.owl CHEBI:33402 biolink:NamedThing sulfur oxoacid RBO_relaxed.owl CHEBI:33833 biolink:NamedThing heteroarene A heterocyclic compound formally derived from an arene by replacement of one or more methine (-C=) and/or vinylene (-CH=CH-) groups by trivalent or divalent heteroatoms, respectively, in such a way as to maintain the continuous pi-electron system characteristic of aromatic systems and a number of out-of-plane pi-electrons corresponding to the Hueckel rule (4n+2). RBO_relaxed.owl CHEBI:27027 biolink:NamedThing micronutrient Any nutrient required in small quantities by organisms throughout their life in order to orchestrate a range of physiological functions. RBO_relaxed.owl CHEBI:33284 biolink:NamedThing nutrient A nutrient is a food component that an organism uses to survive and grow. RBO_relaxed.owl CHEBI:33937 biolink:NamedThing macronutrient Any nutrient required in large quantities by organisms throughout their life in order to orchestrate a range of physiological functions. Macronutrients are usually chemical elements (carbon, hydrogen, nitrogen, oxygen, phosphorus and sulfur) that humans consume in the largest quantities. Calcium, sodium, magnesium and potassium are sometimes included as macronutrients because they are required in relatively large quantities compared with other vitamins and minerals. RBO_relaxed.owl CHEBI:38166 biolink:NamedThing organic heteropolycyclic compound RBO_relaxed.owl CHEBI:37838 biolink:NamedThing carboacyl group A carboacyl group is a group formed by loss of at least one OH from the carboxy group of a carboxylic acid. RBO_relaxed.owl CHEBI:27214 biolink:NamedThing uranium atom RBO_relaxed.owl CHEBI:33320 biolink:NamedThing actinoid atom RBO_relaxed.owl CHEBI:33337 biolink:NamedThing actinium atom RBO_relaxed.owl CHEBI:33385 biolink:NamedThing thorium RBO_relaxed.owl CHEBI:33386 biolink:NamedThing protactinium atom RBO_relaxed.owl CHEBI:33387 biolink:NamedThing neptunium atom RBO_relaxed.owl CHEBI:33388 biolink:NamedThing plutonium atom RBO_relaxed.owl CHEBI:33389 biolink:NamedThing americium atom RBO_relaxed.owl CHEBI:33390 biolink:NamedThing curium atom RBO_relaxed.owl CHEBI:33391 biolink:NamedThing berkelium atom RBO_relaxed.owl CHEBI:33392 biolink:NamedThing californium atom RBO_relaxed.owl CHEBI:33393 biolink:NamedThing einsteinium atom RBO_relaxed.owl CHEBI:33394 biolink:NamedThing fermium RBO_relaxed.owl CHEBI:33395 biolink:NamedThing mendelevium atom RBO_relaxed.owl CHEBI:33396 biolink:NamedThing nobelium RBO_relaxed.owl CHEBI:33397 biolink:NamedThing lawrencium atom RBO_relaxed.owl CHEBI:27369 biolink:NamedThing zwitterion A neutral compound having formal unit electrical charges of opposite sign on non-adjacent atoms. Sometimes referred to as inner salts, dipolar ions (a misnomer). RBO_relaxed.owl CHEBI:33358 biolink:NamedThing cobalt group element atom RBO_relaxed.owl CHEBI:33359 biolink:NamedThing rhodium atom A cobalt group element atom of atomic number 45. RBO_relaxed.owl CHEBI:33361 biolink:NamedThing meitnerium atom RBO_relaxed.owl CHEBI:49666 biolink:NamedThing iridium atom RBO_relaxed.owl CHEBI:28073 biolink:NamedThing chromium atom A chromium group element atom that has atomic number 24. RBO_relaxed.owl CHEBI:28694 biolink:NamedThing copper atom RBO_relaxed.owl CHEBI:33363 biolink:NamedThing palladium Chemical element (nickel group element atom) with atomic number 46. RBO_relaxed.owl CHEBI:27698 biolink:NamedThing vanadium atom RBO_relaxed.owl CHEBI:33347 biolink:NamedThing vanadium group element atom RBO_relaxed.owl CHEBI:33344 biolink:NamedThing niobium atom RBO_relaxed.owl CHEBI:33348 biolink:NamedThing tantalum atom RBO_relaxed.owl CHEBI:33349 biolink:NamedThing dubnium atom RBO_relaxed.owl CHEBI:27998 biolink:NamedThing tungsten RBO_relaxed.owl CHEBI:33350 biolink:NamedThing chromium group element atom RBO_relaxed.owl CHEBI:33351 biolink:NamedThing seaborgium atom RBO_relaxed.owl CHEBI:28087 biolink:NamedThing glycogen A polydisperse, highly branched glucan composed of chains of D-glucopyranose residues in alpha(1->4) glycosidic linkage, joined together by alpha(1->6) glycosidic linkages. A small number of alpha(1->3) glycosidic linkages and some cumulative alpha(1->6) links also may occur. The branches in glycogen typically contain 8 to 12 glucose residues. RBO_relaxed.owl CHEBI:33362 biolink:NamedThing nickel group element atom RBO_relaxed.owl CHEBI:33364 biolink:NamedThing platinum RBO_relaxed.owl CHEBI:33367 biolink:NamedThing darmstadtium RBO_relaxed.owl CHEBI:28976 biolink:NamedThing carbonic acid RBO_relaxed.owl CHEBI:33366 biolink:NamedThing copper group element atom RBO_relaxed.owl CHEBI:29287 biolink:NamedThing gold atom RBO_relaxed.owl CHEBI:30512 biolink:NamedThing silver atom RBO_relaxed.owl CHEBI:33368 biolink:NamedThing roentgenium atom A copper group element atom with atomic number 111. The the ninth member of the 6d series of transition metals, it is an extremely radioactive, synthetic element. Average mass is around 281. RBO_relaxed.owl CHEBI:33567 biolink:NamedThing catecholamine 4-(2-Aminoethyl)pyrocatechol [4-(2-aminoethyl)benzene-1,2-diol] and derivatives formed by substitution. RBO_relaxed.owl CHEBI:33570 biolink:NamedThing benzenediols RBO_relaxed.owl CHEBI:35106 biolink:NamedThing nitrogen hydride RBO_relaxed.owl CHEBI:29337 biolink:NamedThing azanide RBO_relaxed.owl CHEBI:50313 biolink:NamedThing onium cation Mononuclear cations derived by addition of a hydron to a mononuclear parent hydride of the pnictogen, chalcogen and halogen families. RBO_relaxed.owl CHEBI:28965 biolink:NamedThing dicarboxylic acid dianion A carboxylic acid dianion obtained by deprotonation of both carboxy groups of any dicarboxylic acid. RBO_relaxed.owl CHEBI:35693 biolink:NamedThing dicarboxylic acid anion RBO_relaxed.owl CHEBI:38716 biolink:NamedThing carboxylic acid dianion Any dianion containing at least one carboxy group. RBO_relaxed.owl CHEBI:36961 biolink:NamedThing chalcocarbonic acid RBO_relaxed.owl CHEBI:29067 biolink:NamedThing carboxylic acid anion The conjugate base formed when the carboxy group of a carboxylic acid is deprotonated. RBO_relaxed.owl CHEBI:59252 biolink:NamedThing linear tetrapyrrole anion An organic anion arising from deprotonation of a acyclic tetrapyrrole compound. RBO_relaxed.owl CHEBI:33485 biolink:NamedThing chalcogen oxoanion RBO_relaxed.owl CHEBI:33504 biolink:NamedThing alkali metal cation RBO_relaxed.owl CHEBI:29236 biolink:NamedThing protium atom The stable isotope of hydrogen with relative atomic mass 1.007825 and a natural abundance of 99.9885 atom percent (from Greek pirhoomegatauomicronsigma, first). RBO_relaxed.owl CHEBI:29237 biolink:NamedThing deuterium atom The stable isotope of hydrogen with relative atomic mass 2.014102 and a natural abundance of 0.0115 atom percent (from Greek deltaepsilonupsilontauepsilonrhoomicronnu, second). RBO_relaxed.owl CHEBI:29238 biolink:NamedThing tritium atom The radioactive isotope of hydrogen with relative atomic mass 3.016049 and half-life of 12.33 years (from Greek taurhoiotatauomicronsigma, third). RBO_relaxed.owl CHEBI:79389 biolink:NamedThing monovalent inorganic anion Any inorganic anion with a valency of one. RBO_relaxed.owl CHEBI:30089 biolink:NamedThing acetate A monocarboxylic acid anion resulting from the removal of a proton from the carboxy group of acetic acid. RBO_relaxed.owl CHEBI:35757 biolink:NamedThing monocarboxylic acid anion A carboxylic acid anion formed when the carboxy group of a monocarboxylic acid is deprotonated. RBO_relaxed.owl CHEBI:36235 biolink:NamedThing bile acid anion RBO_relaxed.owl CHEBI:30212 biolink:NamedThing photon Particle of zero charge, zero rest mass, spin quantum number 1, energy hnu and momentum hnu/c (h is the Planck constant, nu the frequency of radiation and c the speed of light), carrier of electromagnetic force. RBO_relaxed.owl CHEBI:36341 biolink:NamedThing boson Particle of integer spin quantum number following Bose-Einstein statistics. Bosons are named after Satyendra Nath Bose. RBO_relaxed.owl CHEBI:36345 biolink:NamedThing meson A hadron with zero or integer spin; a strongly interacting boson. The term is derived from the Greek muepsilonsigmaomicronsigma (medium, middle). RBO_relaxed.owl CHEBI:33316 biolink:NamedThing helium(2+) RBO_relaxed.owl CHEBI:30218 biolink:NamedThing helium-3 atom The stable isotope of helium with relative atomic mass 3.016029. The least abundant (0.000137 atom percent) isotope of naturally occurring helium. RBO_relaxed.owl CHEBI:30219 biolink:NamedThing helium-4 atom The stable isotope of helium with relative atomic mass 4.002603. The most abundant (99.99 atom percent) isotope of naturally occurring helium. RBO_relaxed.owl CHEBI:37003 biolink:NamedThing helium-6 atom The radioactive isotope of helium with relative atomic mass 6.01889 and half-life of 806.7 ms. RBO_relaxed.owl CHEBI:37004 biolink:NamedThing helium-8 atom The radioactive isotope of helium with relative atomic mass 8.03392 and half-life of 119.0 ms. RBO_relaxed.owl CHEBI:33365 biolink:NamedThing platinum group metal atom RBO_relaxed.owl CHEBI:3098 biolink:NamedThing bile acid Any member of a group of hydroxy-5beta-cholanic acids occuring in bile, where they are present as the sodium salts of their amides with glycine or taurine. In mammals bile acids almost invariably have 5beta-configuration. RBO_relaxed.owl CHEBI:32988 biolink:NamedThing amide An amide is a derivative of an oxoacid RkE(=O)l(OH)m (l =/= 0) in which an acidic hydroxy group has been replaced by an amino or substituted amino group. RBO_relaxed.owl CHEBI:33267 biolink:NamedThing elemental nitrogen RBO_relaxed.owl CHEBI:32999 biolink:NamedThing europium atom RBO_relaxed.owl CHEBI:33319 biolink:NamedThing lanthanoid atom RBO_relaxed.owl CHEBI:33336 biolink:NamedThing lanthanum atom RBO_relaxed.owl CHEBI:33369 biolink:NamedThing cerium RBO_relaxed.owl CHEBI:33372 biolink:NamedThing neodymium atom RBO_relaxed.owl CHEBI:33373 biolink:NamedThing promethium atom RBO_relaxed.owl CHEBI:33374 biolink:NamedThing samarium atom RBO_relaxed.owl CHEBI:33375 biolink:NamedThing gadolinium atom RBO_relaxed.owl CHEBI:33376 biolink:NamedThing terbium atom RBO_relaxed.owl CHEBI:33377 biolink:NamedThing dysprosium atom RBO_relaxed.owl CHEBI:33379 biolink:NamedThing erbium RBO_relaxed.owl CHEBI:33380 biolink:NamedThing thulium atom RBO_relaxed.owl CHEBI:33381 biolink:NamedThing ytterbium RBO_relaxed.owl CHEBI:33382 biolink:NamedThing lutetium atom RBO_relaxed.owl CHEBI:49648 biolink:NamedThing holmium atom RBO_relaxed.owl CHEBI:49828 biolink:NamedThing praseodymium atom RBO_relaxed.owl CHEBI:33562 biolink:NamedThing f-block element atom RBO_relaxed.owl CHEBI:33233 biolink:NamedThing fundamental particle A particle not known to have substructure. RBO_relaxed.owl CHEBI:36340 biolink:NamedThing fermion Particle of half-integer spin quantum number following Fermi-Dirac statistics. Fermions are named after Enrico Fermi. RBO_relaxed.owl CHEBI:36343 biolink:NamedThing composite particle A subatomic particle known to have substructure (i.e. consisting of smaller particles). RBO_relaxed.owl CHEBI:36347 biolink:NamedThing nuclear particle A nucleus or any of its constituents in any of their energy states. RBO_relaxed.owl CHEBI:37175 biolink:NamedThing organic hydride RBO_relaxed.owl CHEBI:33249 biolink:NamedThing organyl group Any organic substituent group, regardless of functional type, having one free valence at a carbon atom. RBO_relaxed.owl OBO:RBO_00005036 biolink:NamedThing highly charged energetic nucleus Fully ionized atomic nucleus with 2 or more protons and energies in excess of tens of MeV per nucleon RBO_relaxed.owl CHEBI:36339 biolink:NamedThing baryon Baryon is a fermion that does experience the strong force (strong interaction). The term is derived from the Greek betaalpharhoupsilonsigma (heavy). RBO_relaxed.owl CHEBI:33256 biolink:NamedThing primary amide A derivative of an oxoacid RkE(=O)l(OH)m (l =/= 0) in which an acidic hydroxy group has been replaced by an amino or substituted amino group. RBO_relaxed.owl CHEBI:33281 biolink:NamedThing antimicrobial agent A substance that kills or slows the growth of microorganisms, including bacteria, viruses, fungi and protozoans. RBO_relaxed.owl CHEBI:52209 biolink:NamedThing aetiopathogenetic role A role played by the molecular entity or part thereof which causes the development of a pathological process. RBO_relaxed.owl CHEBI:52210 biolink:NamedThing pharmacological role A biological role which describes how a drug interacts within a biological system and how the interactions affect its medicinal properties. RBO_relaxed.owl CHEBI:52211 biolink:NamedThing physiological role RBO_relaxed.owl CHEBI:53000 biolink:NamedThing epitope The biological role played by a material entity when bound by a receptor of the adaptive immune system. Specific site on an antigen to which an antibody binds. RBO_relaxed.owl CHEBI:64909 biolink:NamedThing poison Any substance that causes disturbance to organisms by chemical reaction or other activity on the molecular scale, when a sufficient quantity is absorbed by the organism. RBO_relaxed.owl OBO:RBO_00000070 biolink:NamedThing radioprotectant A substance present at the time of irradiation that mitigates or prevents the biological effects of irradiation. RBO_relaxed.owl OBO:RBO_00000071 biolink:NamedThing radionuclide chelator Radionuclide chelators are small organic molecules or in some cases larger peptides that chemically sequester the radionuclide ion by forming a complex that determines the thermodynamic stability and kinetic inertness of the radionuclide. RBO_relaxed.owl OBO:RBO_00000072 biolink:NamedThing co-carcinogen A co-carcinogen is generally a chemical that promotes the effects of a carcinogen in the production of cancer. In some circumstances exposure to radiation or physical trauma is considered to be co-carcinogenic. RBO_relaxed.owl OBO:RBO_00000073 biolink:NamedThing radiation response modifier Radiation response modifiers are agents that alter tumor or normal tissue response to radiation, such as radiation sensitizers and radiation protectors. RBO_relaxed.owl CHEBI:78295 biolink:NamedThing food component A physiological role played by any substance that is distributed in foodstuffs. It includes materials derived from plants or animals, such as vitamins or minerals, as well as environmental contaminants. RBO_relaxed.owl CHEBI:33287 biolink:NamedThing fertilizer A fertilizer is any substance that is added to soil or water to assist the growth of plants. RBO_relaxed.owl CHEBI:33679 biolink:NamedThing helium molecular entity RBO_relaxed.owl CHEBI:33680 biolink:NamedThing elemental helium RBO_relaxed.owl CHEBI:33321 biolink:NamedThing rare earth metal atom RBO_relaxed.owl CHEBI:33330 biolink:NamedThing scandium atom RBO_relaxed.owl CHEBI:33331 biolink:NamedThing yttrium atom RBO_relaxed.owl CHEBI:33335 biolink:NamedThing scandium group element atom RBO_relaxed.owl CHEBI:33561 biolink:NamedThing d-block element atom RBO_relaxed.owl CHEBI:33345 biolink:NamedThing titanium group element atom RBO_relaxed.owl CHEBI:33341 biolink:NamedThing titanium atom RBO_relaxed.owl CHEBI:33342 biolink:NamedThing zirconium atom RBO_relaxed.owl CHEBI:33343 biolink:NamedThing hafnium atom RBO_relaxed.owl CHEBI:33346 biolink:NamedThing rutherfordium atom RBO_relaxed.owl CHEBI:33371 biolink:NamedThing technetium-99 RBO_relaxed.owl CHEBI:33424 biolink:NamedThing sulfur oxoacid derivative RBO_relaxed.owl CHEBI:33484 biolink:NamedThing chalcogen oxoacid RBO_relaxed.owl CHEBI:33457 biolink:NamedThing phosphorus oxoacid A pnictogen oxoacid which contains phosphorus and oxygen, at least one hydrogen atom bound to oxygen, and forms an ion by the loss of one or more protons. RBO_relaxed.owl CHEBI:36360 biolink:NamedThing phosphorus oxoacids and derivatives RBO_relaxed.owl CHEBI:33461 biolink:NamedThing phosphorus oxoanion RBO_relaxed.owl CHEBI:33491 biolink:NamedThing radon-220 atom RBO_relaxed.owl CHEBI:33492 biolink:NamedThing radon-222 atom RBO_relaxed.owl CHEBI:33493 biolink:NamedThing radon-219 atom RBO_relaxed.owl CHEBI:33498 biolink:NamedThing actinoid molecular entity RBO_relaxed.owl CHEBI:33677 biolink:NamedThing f-block molecular entity RBO_relaxed.owl CHEBI:33499 biolink:NamedThing uranium molecular entity RBO_relaxed.owl CHEBI:33566 biolink:NamedThing catechols Any compound containing an o-diphenol component. RBO_relaxed.owl CHEBI:33635 biolink:NamedThing polycyclic compound RBO_relaxed.owl CHEBI:33636 biolink:NamedThing bicyclic compound A molecule that features two fused rings. RBO_relaxed.owl CHEBI:33655 biolink:NamedThing aromatic compound A cyclically conjugated molecular entity with a stability (due to delocalization) significantly greater than that of a hypothetical localized structure (e.g. Kekule structure) is said to possess aromatic character. RBO_relaxed.owl CHEBI:33676 biolink:NamedThing d-block molecular entity A d-block molecular entity is a molecular entity containing one or more atoms of a d-block element. RBO_relaxed.owl CHEBI:36908 biolink:NamedThing argon molecular entity RBO_relaxed.owl CHEBI:33700 biolink:NamedThing proteinogenic amino-acid residue RBO_relaxed.owl CHEBI:33710 biolink:NamedThing alpha-amino-acid residue An amino-acid residue derived from an alpha-amino acid. RBO_relaxed.owl CHEBI:33704 biolink:NamedThing alpha-amino acid An amino acid in which the amino group is located on the carbon atom at the position alpha to the carboxy group. RBO_relaxed.owl CHEBI:33721 biolink:NamedThing carbohydrate acid anion RBO_relaxed.owl CHEBI:50160 biolink:NamedThing steroid acid anion Any anion formed by loss of a proton from a steroid acid. RBO_relaxed.owl CHEBI:33745 biolink:NamedThing copper group molecular entity RBO_relaxed.owl CHEBI:33747 biolink:NamedThing nickel group molecular entity RBO_relaxed.owl CHEBI:33749 biolink:NamedThing platinum molecular entity RBO_relaxed.owl CHEBI:33791 biolink:NamedThing canonical nucleoside residue RBO_relaxed.owl CHEBI:33792 biolink:NamedThing canonical ribonucleoside residue RBO_relaxed.owl CHEBI:33793 biolink:NamedThing canonical deoxyribonucleoside residue RBO_relaxed.owl CHEBI:33815 biolink:NamedThing oxygen-18 atom The stable isotope of oxygen with relative atomic mass 17.999160 and 0.205 atom percent natural abundance. RBO_relaxed.owl CHEBI:33818 biolink:NamedThing oxygen-16 atom The stable isotope of oxygen with relative atomic mass 15.994914. The most abundant (99.76 atom percent) isotope of naturally occurring oxygen. RBO_relaxed.owl CHEBI:33819 biolink:NamedThing oxygen-17 atom The stable isotope of oxygen with relative atomic mass 16.999131. The least abundant (0.038 atom percent) isotope of naturally occurring oxygen. RBO_relaxed.owl CHEBI:36932 biolink:NamedThing oxygen-15 atom The radioactive isotope of oxygen with relative atomic mass 15.003065. The longest-lived oxygen radionuclide with half-life of 122.2 s. RBO_relaxed.owl CHEBI:36933 biolink:NamedThing oxygen-19 atom RBO_relaxed.owl CHEBI:36080 biolink:NamedThing protein A biological macromolecule minimally consisting of one polypeptide chain synthesized at the ribosome. RBO_relaxed.owl PR:000000001 biolink:NamedThing protein An amino acid chain that is produced de novo by ribosome-mediated translation of a genetically-encoded mRNA, and any derivatives thereof. RBO_relaxed.owl PR:000001002 biolink:NamedThing CD19 molecule A protein that is a translation product of the human CD19 gene or a 1:1 ortholog thereof. It is composed of an N-terminal extracellular domain containing two Ig-like C2-type (immunoglobulin-like) domains, followed by a single-pass transmembrane segment and a cytoplasmic C-terminal tail. CD19 expression is restricted to members of the B cell lineage. It functions as a co-receptor for B-cell antigen receptor (BCR), regulating signal transduction. RBO_relaxed.owl PR:000001003 biolink:NamedThing CD34 molecule A protein that is a translation product of the human CD34 gene or a 1:1 ortholog thereof. It is a leukocyte membrane protein expressed specifically by lymphohematopoietic progenitor cells. It contains a single-pass transmembrane domain and that show distinct expression on early hematopoietic precursors and vascular-associated tissue. Acts as a scaffold that presents selectin carbohydrate ligands in a clustered, tissue specific manner to allow for higher avidity interactions between leukocytes and endothelial cells during the inflammatory process. In common with related sialomucins (endoglycan and podocalyxin), the extracellular region is dominated by an N-terminal mucin-like domain, which is densely substituted with sialylated O-linked carbohydrates. The mucin-like region is followed by a cysteine-containing and presumably globular domain. This domain may fold into an immunoglobulin-like structure as the positions of 2 of the cysteines are conserved in the C2 set of the immunoglobulin superfamily. The cytoplasmic domain is around 73-76 residues long and highly conserved. RBO_relaxed.owl PR:000001004 biolink:NamedThing CD4 molecule A protein that is a translation product of the human CD4 gene or a 1:1 ortholog thereof. CD4 is an accessory protein for MHC class-II antigen/T-cell receptor interaction. It is the primary receptor for HIV-1. CD4 has four immunoglobulin-like domains in its extracellular region that share the same structure, but can differ in sequence. RBO_relaxed.owl PR:000001018 biolink:NamedThing CD3 subunit with immunoglobulin domain A protein that has a core domain composition consisting of an extracellular N-terminal domain that adopts an immunoglobulin fold, a transmembrane domain, and an intracellular C-terminal domain with a single copy of the Immunoreceptor tyrosine-based activation motif (Pfam:PF02189) (ITAM). It constitutes the invariant subunit of the T cell antigen receptor (TCR). TCR is a surface receptor on T cells responsible for recognizing MHC-restricted antigens and initiating the cellular immune response. RBO_relaxed.owl PR:000001022 biolink:NamedThing neural cell adhesion molecule A protein with a domain composition consisting of a large extracellular domain, including five Ig-like C2-type domains followed by two copies of the Fibronectin type-III domain (Pfam:PF00041), a single-pass transmembrane domain and a short cytoplasmic C-terminal domain. RBO_relaxed.owl PR:000001083 biolink:NamedThing CD2 molecule A protein that is a translation product of the human CD2 gene or a 1:1 ortholog thereof. RBO_relaxed.owl PR:000001084 biolink:NamedThing T-cell surface glycoprotein CD8 alpha chain A protein that is a translation product of the human CD8A gene or a 1:1 ortholog thereof. CD8 is a transmembrane that is a co-receptor for MHC class-I antigen/T-cell receptor interaction. The most common form of CD8 is composed of a CD8 alpha and a CD8 beta chain. RBO_relaxed.owl PR:000001289 biolink:NamedThing membrane-spanning 4-domains subfamily A member 1 A protein that is a translation product of the human MS4A1 gene or a 1:1 ortholog thereof. RBO_relaxed.owl PR:000001327 biolink:NamedThing cadherin A protein that has a core domain structure of signal sequence, propeptide, five Cadherin domains (Pfam:PF00028), a transmembrane region, and a Cadherin cytoplasmic region (Pfam:PF01049). Cadherins function as adhesion molecules that mediate Ca2+-dependent cell-cell adhesion in solid tissues. RBO_relaxed.owl PR:000001839 biolink:NamedThing T-cell surface glycoprotein CD5 A protein that is a translation product of the human CD5 gene or a 1:1 ortholog thereof. RBO_relaxed.owl PR:000001869 biolink:NamedThing interleukin-7 receptor subunit alpha A protein that is a translation product of the human IL7R gene or a 1:1 ortholog thereof. RBO_relaxed.owl PR:000001889 biolink:NamedThing CD14 molecule A protein that is a translation product of the human CD14 gene or a 1:1 ortholog thereof. RBO_relaxed.owl PR:000001945 biolink:NamedThing transferrin receptor protein 1 A protein that is a translation product of the human TFRC gene or a 1:1 ortholog thereof. RBO_relaxed.owl PR:000001971 biolink:NamedThing vascular endothelial growth factor receptor A protein with core architecture consisting of a signal sequence, followed by 7 Ig-like domains (Pfam:PF00047, Pfam:PF07679, or Pfam:PF07686), a transmembrane region, and a cytoplasmic Protein tyrosine kinase domain. RBO_relaxed.owl PR:000002976 biolink:NamedThing Ly-6-like protein A protein that is the translation product of any of the LY6 genes (LY6A-LY6I). RBO_relaxed.owl PR:000007499 biolink:NamedThing fibroblast growth factor 8 A protein that is a translation product of the human FGF8 gene or a 1:1 ortholog thereof. RBO_relaxed.owl PR:000014841 biolink:NamedThing sonic hedgehog protein A protein that is a translation product of the human SHH gene or a 1:1 ortholog thereof. RBO_relaxed.owl PR:000016043 biolink:NamedThing T-cell acute lymphocytic leukemia protein 1 A protein that is a translation product of the human TAL1 gene or a 1:1 ortholog thereof. RBO_relaxed.owl PR:000025796 biolink:NamedThing integrin alpha A protein that is composed of a long N-terminal extracellular domain, a transmembrane domain and a short cytoplasmic C-terminal domain. The N-terminal domain contains beta-propeller repeats (interrupted by an A domain in a subset of integrins alpha), while the C-terminal domain contains a GFFxR motif. RBO_relaxed.owl PR:000036194 biolink:NamedThing eukaryotic protein A protein that is encoded in the genome of some Eukaryota. RBO_relaxed.owl PR:000045358 biolink:NamedThing insulin family protein A protein that is a translation product of a gene that encodes a standalone Insulin (Pfam:PF00049) domain preceded by a signal peptide. RBO_relaxed.owl PR:000029032 biolink:NamedThing Mus musculus protein A protein that is encoded in the genome of Mus musculus. RBO_relaxed.owl PR:000029067 biolink:NamedThing Homo sapiens protein A protein that is encoded in the genome of Homo sapiens. RBO_relaxed.owl CHEBI:33969 biolink:NamedThing gold molecular entity RBO_relaxed.owl CHEBI:35230 biolink:NamedThing fossil fuel RBO_relaxed.owl CHEBI:35238 biolink:NamedThing amino acid zwitterion The zwitterionic form of an amino acid having a negatively charged carboxyl group and a positively charged amino group. RBO_relaxed.owl CHEBI:60466 biolink:NamedThing peptide zwitterion Zwitterionic form of any peptide where, in general, the amino terminus is positively charged and the carboxy terminus is negatively charged. RBO_relaxed.owl CHEBI:35472 biolink:NamedThing anti-inflammatory drug A substance that reduces or suppresses inflammation. RBO_relaxed.owl CHEBI:35554 biolink:NamedThing cardiovascular drug A drug that affects the rate or intensity of cardiac contraction, blood vessel diameter or blood volume. RBO_relaxed.owl CHEBI:35942 biolink:NamedThing neurotransmitter agent A substance used for its pharmacological action on any aspect of neurotransmitter systems. Neurotransmitter agents include agonists, antagonists, degradation inhibitors, uptake inhibitors, depleters, precursors, and modulators of receptor function. RBO_relaxed.owl CHEBI:35507 biolink:NamedThing natural product fundamental parent RBO_relaxed.owl CHEBI:35524 biolink:NamedThing sympathomimetic agent A drug that mimics the effects of stimulating postganglionic adrenergic sympathetic nerves. Included in this class are drugs that directly stimulate adrenergic receptors and drugs that act indirectly by provoking the release of adrenergic transmitters. RBO_relaxed.owl CHEBI:37962 biolink:NamedThing adrenergic agent Any agent that acts on an adrenergic receptor or affects the life cycle of an adrenergic transmitter. RBO_relaxed.owl CHEBI:37886 biolink:NamedThing adrenergic agonist An agent that selectively binds to and activates adrenergic receptors. RBO_relaxed.owl CHEBI:48539 biolink:NamedThing alpha-adrenergic drug Any drug that acts on an alpha-adrenergic receptor. RBO_relaxed.owl CHEBI:35569 biolink:NamedThing alpha-adrenergic agonist An agent that selectively binds to and activates alpha-adrenergic receptors. RBO_relaxed.owl CHEBI:35620 biolink:NamedThing vasodilator agent A drug used to cause dilation of the blood vessels. RBO_relaxed.owl CHEBI:50514 biolink:NamedThing vasoconstrictor agent Drug used to cause constriction of the blood vessels. RBO_relaxed.owl CHEBI:35722 biolink:NamedThing sulfated glycosaminoglycan RBO_relaxed.owl CHEBI:36237 biolink:NamedThing cholanic acid A steroid acid that consists of cholane having a carboxy group in place of the methyl group at position 24. RBO_relaxed.owl CHEBI:36344 biolink:NamedThing hadron Hadron is a subatomic particle which experiences the strong force. RBO_relaxed.owl CHEBI:36348 biolink:NamedThing pi meson The collective name for zero-spin mesons pi(+), pi(-) and pi(0). RBO_relaxed.owl CHEBI:36927 biolink:NamedThing carbon-14 atom RBO_relaxed.owl CHEBI:36928 biolink:NamedThing carbon-13 atom RBO_relaxed.owl CHEBI:36929 biolink:NamedThing carbon-11 atom RBO_relaxed.owl CHEBI:36930 biolink:NamedThing carbon-10 atom RBO_relaxed.owl CHEBI:36931 biolink:NamedThing carbon-12 atom RBO_relaxed.owl CHEBI:36934 biolink:NamedThing nitrogen-15 atom The stable isotope of nitrogen with relative atomic mass 15.000109. The least abundant (0.368 atom percent) isotope of naturally occurring nitrogen. RBO_relaxed.owl CHEBI:36935 biolink:NamedThing nitrogen-13 atom The radioactive isotope of nitrogen with relative atomic mass 13.0057386. The longest-lived nitrogen radionuclide with half-life of 9.965 min. RBO_relaxed.owl CHEBI:36936 biolink:NamedThing nitrogen-16 atom RBO_relaxed.owl CHEBI:36937 biolink:NamedThing nitrogen-17 atom RBO_relaxed.owl CHEBI:36938 biolink:NamedThing nitrogen-14 atom The stable isotope of nitrogen with relative atomic mass 14.003074. The most abundant (99.63 atom percent) isotope of naturally occurring nitrogen. RBO_relaxed.owl CHEBI:36939 biolink:NamedThing fluorine-18 atom The radioactive isotope of fluorine with relative atomic mass 18.000938. The longest-lived fluorine radionuclide with half-life of 109.77 min. RBO_relaxed.owl CHEBI:36940 biolink:NamedThing fluorine-19 atom The stable isotope of fluorine with relative atomic mass 18.998403 and nuclear spin (1)/2. RBO_relaxed.owl CHEBI:37164 biolink:NamedThing homopolysaccharide Glycans composed of a single type of monosaccharide residue. They are named by replacing the ending '-ose' of the sugar by '-an'. RBO_relaxed.owl CHEBI:37340 biolink:NamedThing polonium-210 atom The radioactive isotope of polonium with relative atomic mass 209.98286 and half-life of 138.376 days; the only naturally occurring isotope of polonium. RBO_relaxed.owl CHEBI:37341 biolink:NamedThing polonium-211 atom The radioactive isotope of polonium with relative atomic mass 210.986637 and half-life of 0.516 s. RBO_relaxed.owl CHEBI:37342 biolink:NamedThing polonium-212 atom The radioactive isotope of polonium with relative atomic mass 211.988852 and half-life of 0.299 mus. RBO_relaxed.owl CHEBI:37343 biolink:NamedThing polonium-213 atom The radioactive isotope of polonium with relative atomic mass 212.9928425 and half-life of 4.2 mus. RBO_relaxed.owl CHEBI:37344 biolink:NamedThing polonium-214 atom The radioactive isotope of polonium with relative atomic mass 213.995186 and half-life of 164.3 mus. RBO_relaxed.owl CHEBI:37345 biolink:NamedThing polonium-215 atom The radioactive isotope of polonium with relative atomic mass 214.999415 and half-life of 1.781 ms. RBO_relaxed.owl CHEBI:37346 biolink:NamedThing polonium-216 atom The radioactive isotope of polonium with relative atomic mass 216.001905 and half-life of 0.145 s. RBO_relaxed.owl CHEBI:37347 biolink:NamedThing polonium-217 atom The radioactive isotope of polonium with relative atomic mass 217.006253 and half-life of < 10 s. RBO_relaxed.owl CHEBI:37348 biolink:NamedThing polonium-218 atom The radioactive isotope of polonium with relative atomic mass 218.008966 and half-life of 3.10 min. RBO_relaxed.owl CHEBI:37350 biolink:NamedThing polonium-190 atom RBO_relaxed.owl CHEBI:37351 biolink:NamedThing polonium-191 atom RBO_relaxed.owl CHEBI:37352 biolink:NamedThing polonium-192 atom RBO_relaxed.owl CHEBI:37353 biolink:NamedThing polonium-193 atom RBO_relaxed.owl CHEBI:37354 biolink:NamedThing polonium-194 atom RBO_relaxed.owl CHEBI:37355 biolink:NamedThing polonium-195 atom RBO_relaxed.owl CHEBI:37356 biolink:NamedThing polonium-196 atom RBO_relaxed.owl CHEBI:37357 biolink:NamedThing polonium-197 atom RBO_relaxed.owl CHEBI:37358 biolink:NamedThing polonium-198 atom RBO_relaxed.owl CHEBI:37359 biolink:NamedThing polonium-199 atom RBO_relaxed.owl CHEBI:37360 biolink:NamedThing polonium-200 atom RBO_relaxed.owl CHEBI:37361 biolink:NamedThing polonium-201 atom RBO_relaxed.owl CHEBI:37362 biolink:NamedThing polonium-202 atom RBO_relaxed.owl CHEBI:37363 biolink:NamedThing polonium-203 atom The radioactive isotope of polonium with relative atomic mass 202.981413 and half-life of 36.7 min. RBO_relaxed.owl CHEBI:37364 biolink:NamedThing polonium-204 atom RBO_relaxed.owl CHEBI:37365 biolink:NamedThing polonium-205 atom The radioactive isotope of polonium with relative atomic mass 204.981165 and half-life of 1.66 h. RBO_relaxed.owl CHEBI:37366 biolink:NamedThing polonium-206 atom The radioactive isotope of polonium with relative atomic mass 205.98047 and half-life of 8.8 days. RBO_relaxed.owl CHEBI:37367 biolink:NamedThing polonium-207 atom The radioactive isotope of polonium with relative atomic mass 206.981578 and half-life of 5.80 h. RBO_relaxed.owl CHEBI:37368 biolink:NamedThing polonium-208 atom The radioactive isotope of polonium with relative atomic mass 207.98123 and half-life of 2.898 years. RBO_relaxed.owl CHEBI:37369 biolink:NamedThing polonium-209 atom The radioactive isotope of polonium with relative atomic mass 208.982404 and half-life of 102 years. RBO_relaxed.owl CHEBI:37802 biolink:NamedThing thallium-203 The stable isotope of thallium with relative atomic mass 202.9723. The least abundant (29.524 atom percent) isotope of naturally occurring thallium. RBO_relaxed.owl CHEBI:37803 biolink:NamedThing thallium-205 The stable isotope of thallium with relative atomic mass 204.9744. The most abundant (70.476 atom percent) isotope of naturally occurring thallium. RBO_relaxed.owl CHEBI:37804 biolink:NamedThing thallium-201 The radioactive isotope of thallium with relative atomic mass 200.9708 and half-life of 72.912 hours. RBO_relaxed.owl CHEBI:37805 biolink:NamedThing thallium-199 The radioactive isotope of thallium with relative atomic mass 198.9698 and half-life of 7.42 hours. RBO_relaxed.owl CHEBI:38323 biolink:NamedThing cholinergic drug Any drug used for its actions on cholinergic systems. Included here are agonists and antagonists, drugs that affect the life cycle of acetylcholine, and drugs that affect the survival of cholinergic neurons. RBO_relaxed.owl CHEBI:37968 biolink:NamedThing aluminium-27 atom The stable isotope of aluminium with relative atomic mass 26.98153 and nuclear spin (5)/2. RBO_relaxed.owl CHEBI:37969 biolink:NamedThing aluminium-26 atom The radioactive isotope of aluminium with relative atomic mass 25.986892 and half-life of 717,000 years. RBO_relaxed.owl CHEBI:37970 biolink:NamedThing aluminium-28 atom The radioactive isotope of aluminium with relative atomic mass 27.981910 and half-life of 2.25 min. RBO_relaxed.owl CHEBI:37971 biolink:NamedThing phosphorus-31 atom The stable isotope of phosphorus with relative atomic mass 30.973762 and nuclear spin (1)/2. RBO_relaxed.owl CHEBI:37972 biolink:NamedThing phosphorus-32 atom The radioactive isotope of phosphorus with relative atomic mass 31.973907 and half-life of 14.26 days. RBO_relaxed.owl CHEBI:37973 biolink:NamedThing phosphorus-33 atom The radioactive isotope of phosphorus with relative atomic mass 32.971725, half-life of 25.34 days and nuclear spin (1)/2. RBO_relaxed.owl CHEBI:37974 biolink:NamedThing silicon-29 atom The stable isotope of silicon with relative atomic mass 28.9764947, 4.683 atom percent natural abundancy, and nuclear spin (1)/2. RBO_relaxed.owl CHEBI:37975 biolink:NamedThing silicon-28 atom The stable isotope of silicon with relative atomic mass 27.9769265. The most abundant (92.23 atom percent) isotope of naturally occurring silicon. RBO_relaxed.owl CHEBI:37976 biolink:NamedThing silicon-30 atom The stable isotope of silicon with relative atomic mass 29.9737702. The least abundant (3.09 atom percent) isotope of naturally occurring silicon. RBO_relaxed.owl CHEBI:37977 biolink:NamedThing silicon-31 atom The radioactive isotope of silicon with relative atomic mass 30.975363, half-life of 2.62 hours and nuclear spin (3)/2. RBO_relaxed.owl CHEBI:37978 biolink:NamedThing silicon-32 atom The radioactive isotope of silicon with relative atomic mass 31.974148. The longest-lived silicon radionuclide with half-life of 172 years. RBO_relaxed.owl CHEBI:37979 biolink:NamedThing sulfur-32 atom The stable isotope of sulfur with relative atomic mass 31.972071. The most abundant (95.02 atom percent) isotope of naturally occurring sulfur. RBO_relaxed.owl CHEBI:37980 biolink:NamedThing sulfur-33 atom The stable isotope of sulfur with relative atomic mass 32.9714585, 0.75 atom percent natural abundance, and nuclear spin (3)/2. RBO_relaxed.owl CHEBI:37981 biolink:NamedThing sulfur-34 atom The stable isotope of sulfur with relative atomic mass 33.9678668 and 4.21 atom percent natural abundance. RBO_relaxed.owl CHEBI:37982 biolink:NamedThing sulfur-36 atom The stable isotope of sulfur with relative atomic mass 35.9670809. The least abundant (0.02 atom percent) isotope of naturally occurring sulfur. RBO_relaxed.owl CHEBI:37983 biolink:NamedThing sulfur-35 atom The radioactive isotope of sulfur with relative atomic mass 34.9690322 and nuclear spin (3)/2. The longest-lived sulfur radionuclide with half-life of 87.5 days. RBO_relaxed.owl CHEBI:37984 biolink:NamedThing sulfur-37 atom The radioactive isotope of sulfur with relative atomic mass 36.9711257 and half-life of 5.05 min. RBO_relaxed.owl CHEBI:37985 biolink:NamedThing sulfur-38 atom The radioactive isotope of sulfur with relative atomic mass 37.97116 and half-life of 170.3 min. RBO_relaxed.owl CHEBI:38324 biolink:NamedThing cholinergic agonist Any drug that binds to and activates cholinergic receptors. RBO_relaxed.owl CHEBI:38325 biolink:NamedThing muscarinic agonist Any drug that binds to and activates a muscarinic cholinergic receptor. RBO_relaxed.owl CHEBI:39142 biolink:NamedThing Bronsted base A molecular entity capable of accepting a hydron from a donor (Bronsted acid). RBO_relaxed.owl CHEBI:43176 biolink:NamedThing hydroxy group RBO_relaxed.owl CHEBI:46629 biolink:NamedThing oxo group RBO_relaxed.owl CHEBI:46662 biolink:NamedThing mineral In general, a mineral is a chemical substance that is normally crystalline formed and has been formed as a result of geological processes. The term also includes metamict substances (naturally occurring, formerly crystalline substances whose crystallinity has been destroyed by ionising radiation) and can include naturally occurring amorphous substances that have never been crystalline ('mineraloids') such as georgite and calciouranoite as well as substances formed by the action of geological processes on bigenic compounds ('biogenic minerals'). RBO_relaxed.owl CHEBI:60004 biolink:NamedThing mixture A mixture is a chemical substance composed of multiple molecules, at least two of which are of a different kind. RBO_relaxed.owl CHEBI:46883 biolink:NamedThing carboxy group RBO_relaxed.owl CHEBI:48354 biolink:NamedThing polar solvent A solvent that is composed of polar molecules. Polar solvents can dissolve ionic compounds or ionisable covalent compounds. RBO_relaxed.owl CHEBI:50076 biolink:NamedThing chromium-51 A synthetic radioactive isotope of chromium having a half-life of 27.7 days and decaying by electron capture with emission of gamma rays (0.32 MeV); it is used to label red blood cells for measurement of mass or volume, survival time, and sequestration studies, for the diagnosis of gastrointestinal bleeding, and to label platelets to study their survival. RBO_relaxed.owl CHEBI:50297 biolink:NamedThing canonical nucleotide residue RBO_relaxed.owl CHEBI:50298 biolink:NamedThing canonical deoxyribonucleotide residue RBO_relaxed.owl CHEBI:50299 biolink:NamedThing canonical ribonucleotide residue RBO_relaxed.owl CHEBI:50910 biolink:NamedThing neurotoxin A poison that interferes with the functions of the nervous system. RBO_relaxed.owl CHEBI:52230 biolink:NamedThing tin-119 atom The stable isotope of tin with relative atomic mass 118.903311, 8.59 atom percent natural abundance and nuclear spin (1)/2. RBO_relaxed.owl CHEBI:52231 biolink:NamedThing tin-120 atom The stable isotope of tin with relative atomic mass 119.902199 and 32.58 atom percent natural abundance. RBO_relaxed.owl CHEBI:52232 biolink:NamedThing tin-118 atom The stable isotope of tin with relative atomic mass 117.901609 and 24.22 atom percent natural abundance. RBO_relaxed.owl CHEBI:52233 biolink:NamedThing tin-116 atom The stable isotope of tin with relative atomic mass 115.901747 and 14.54 atom percent natural abundance. RBO_relaxed.owl CHEBI:52234 biolink:NamedThing tin-117 atom The stable isotope of tin with relative atomic mass 116.902956, 7.68 atom percent natural abundance and nuclear spin (1)/2. RBO_relaxed.owl CHEBI:52235 biolink:NamedThing tin-115 atom The stable isotope of tin with relative atomic mass 114.903348, 0.34 atom percent natural abundance and nuclear spin (1)/2. RBO_relaxed.owl CHEBI:52451 biolink:NamedThing boron-11 atom The stable isotope of boron with relative atomic mass 11.009306, 80.1 atom percent natural abundance and nuclear spin 3/2. RBO_relaxed.owl CHEBI:77014 biolink:NamedThing boron-10 atom A stable isotope of boron with relative atomic mass 10.0129370, 19.9 atom percent natural abundance and nuclear spin 3+. RBO_relaxed.owl CHEBI:52452 biolink:NamedThing tellurium-125 atom The stable isotope of tellurium with relative atomic mass 124.904425, 71.4 atom percent natural abundance and nuclear spin 1/2. RBO_relaxed.owl CHEBI:52453 biolink:NamedThing xenon-129 atom The stable isotope of xenon with relative atomic mass 128.904780, 26.4 atom percent natural abundance and nuclear spin 1/2. RBO_relaxed.owl CHEBI:52458 biolink:NamedThing lithium-7 atom The stable isotope of lithium with relative atomic mass 7.016004, 92.5 atom percent natural abundance and nuclear spin 3/2. RBO_relaxed.owl CHEBI:52621 biolink:NamedThing lithium-6 atom The stable isotope of lithium with relative atomic mass 6.015122, 7.5 atom percent natural abundance and nuclear spin 1. RBO_relaxed.owl CHEBI:52460 biolink:NamedThing niobium-93 atom The stable isotope of niobium with relative atomic mass 92.906378, 100 atom percent natural abundance and nuclear spin 9/2. RBO_relaxed.owl CHEBI:52462 biolink:NamedThing tungsten-183 The stable isotope of niobium with relative atomic mass 182.950225, 14.3 atom percent natural abundance and nuclear spin 1/2. RBO_relaxed.owl CHEBI:52619 biolink:NamedThing cadmium-111 The stable isotope of cadmium with relative atomic mass 110.904182, 12.8 atom percent natural abundance and nuclear spin 1/2. RBO_relaxed.owl CHEBI:52620 biolink:NamedThing cadmium-113 The isotope of cadmium with relative atomic mass 112.904401, 12.2 atom percent natural abundance and nuclear spin 1/2. RBO_relaxed.owl CHEBI:52622 biolink:NamedThing yttrium-89 atom The stable isotope of yttrium with relative atomic mass 88.905848, 100 atom percent natural abundance and nuclear spin 1/2. RBO_relaxed.owl CHEBI:52623 biolink:NamedThing iron-57 atom The stable isotope of iron with relative atomic mass 56.935399, 2.1 atom percent natural abundance and nuclear spin 1/2. RBO_relaxed.owl CHEBI:52624 biolink:NamedThing antimony-121 atom The stable isotope of antimony with relative atomic mass 120.903818, 57.2 atom percent natural abundance and nuclear spin 5/2. RBO_relaxed.owl CHEBI:52626 biolink:NamedThing antimony-123 atom The stable isotope of antimony with relative atomic mass 122.904216, 42.8 atom percent natural abundance and nuclear spin 7/2. RBO_relaxed.owl CHEBI:52627 biolink:NamedThing lanthanum-139 atom The stable isotope of lanthanum with relative atomic mass 138.906348, 99.9 atom percent natural abundance and nuclear spin 7/2. RBO_relaxed.owl CHEBI:52631 biolink:NamedThing iodine-127 atom The stable isotope of iodine with relative atomic mass 126.904468, 100 atom percent natural abundance and nuclear spin 5/2. RBO_relaxed.owl CHEBI:52636 biolink:NamedThing iodine-129 atom The isotope of iodine with relative atomic mass 128.904988, and nuclear spin 7/2. RBO_relaxed.owl CHEBI:52632 biolink:NamedThing potassium-39 atom The stable isotope of potassium with relative atomic mass 38.963707, 93.3 atom percent natural abundance and nuclear spin 3/2. RBO_relaxed.owl CHEBI:52634 biolink:NamedThing sodium-23 atom The stable isotope of sodium with relative atomic mass 22.989770, 100 atom percent natural abundance and nuclear spin 3/2. RBO_relaxed.owl CHEBI:52635 biolink:NamedThing scandium-45 atom The stable isotope of scandium with relative atomic mass 44.955910, 100 atom percent natural abundance and nuclear spin 7/2. RBO_relaxed.owl CHEBI:52637 biolink:NamedThing europium-151 atom The stable isotope of europium with relative atomic mass 150.919846, 47.8 atom percent natural abundance and nuclear spin 5/2. RBO_relaxed.owl CHEBI:52743 biolink:NamedThing bromine-79 atom The stable isotope of bromine with relative atomic mass 78.918338, 50.69 atom percent natural abundance and nuclear spin 3/2. RBO_relaxed.owl CHEBI:52758 biolink:NamedThing germanium-73 atom The stable isotope of germanium with relative atomic mass 72.923459, 7.73 atom percent natural abundance and nuclear spin 9/2. RBO_relaxed.owl CHEBI:52763 biolink:NamedThing magnesium-25 atom The stable isotope of magnesium with relative atomic mass 24.985837, 10.0 atom percent natural abundance and nuclear spin 5/2. RBO_relaxed.owl CHEBI:53309 biolink:NamedThing polyanionic macromolecule A polymer carrying multiple negative charges. RBO_relaxed.owl CHEBI:5391 biolink:NamedThing glucagon A 29-amino acid peptide hormone consisting of His, Ser, Gln, Gly, Thr, Phe, Thr, Ser, Asp, Tyr, Ser, Lys, Tyr, Leu, Asp, Ser, Arg, Arg, Ala, Gln, Asp, Phe, Val, Gln, Trp, Leu, Met, Asn and Thr residues joined in sequence. RBO_relaxed.owl CHEBI:64628 biolink:NamedThing somatostatin A fourteen-membered heterodetic cyclic peptide comprising the sequence Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys cyclised by a disulfide bridge between the two Cys residues at positions 3 and 14. RBO_relaxed.owl CHEBI:57887 biolink:NamedThing tryptaminium An ammonium ion that is the conjugate acid of tryptamine arising from protonation of the primary amino group; major species at pH 7.3. RBO_relaxed.owl CHEBI:57977 biolink:NamedThing bilirubin(2-) A dicarboxylic acid dianion obtained by deprotonation of the two carboxy groups of bilirubin; major species at pH 7.3. RBO_relaxed.owl CHEBI:59740 biolink:NamedThing nucleophilic reagent A reagent that forms a bond to its reaction partner (the electrophile) by donating both bonding electrons. RBO_relaxed.owl CHEBI:60027 biolink:NamedThing polymer A polymer is a mixture, which is composed of macromolecules of different kinds and which may be differentiated by composition, length, degree of branching etc.. RBO_relaxed.owl CHEBI:60164 biolink:NamedThing ionic polymer An ionic polymer is a polymer, composed of ionic macromolecules. RBO_relaxed.owl CHEBI:64049 biolink:NamedThing food acidity regulator A food additive that is used to change or otherwise control the acidity or alkalinity of foods. They may be acids, bases, neutralising agents or buffering agents. RBO_relaxed.owl CHEBI:65255 biolink:NamedThing food preservative Substances which are added to food in order to prevent decomposition caused by microbial growth or by undesirable chemical changes. RBO_relaxed.owl CHEBI:77974 biolink:NamedThing food packaging gas A food additive that is a (generally inert) gas which is used to envelop foodstuffs during packing and so protect them from unwanted chemical reactions such as food spoilage or oxidation during subsequent transport and storage. The term includes propellant gases, used to expel foods from a container. RBO_relaxed.owl CHEBI:65256 biolink:NamedThing antimicrobial food preservative A food preservative which prevents decomposition of food by preventing the growth of fungi or bacteria. In European countries, E-numbers for permitted food preservatives are from E200 to E299, divided into sorbates (E200-209), benzoates (E210-219), sulfites (E220-229), phenols and formates (E230-239), nitrates (E240-259), acetates (E260-269), lactates (E270-279), propionates (E280-289) and others (E290-299). RBO_relaxed.owl CHEBI:72587 biolink:NamedThing (R)-noradrenaline(1+) An organic cation that is the conjugate acid of (R)-noradrenaline, obtained by protonation of the priamry amino group; major species at pH 7.3. RBO_relaxed.owl CHEBI:73398 biolink:NamedThing indole skeleton A mancude heterobicyclic organic group consisting of a benzene ring fused to a pyrrole ring. RBO_relaxed.owl CHEBI:73541 biolink:NamedThing organic heterobicyclic ring A bicyclic organic group that contains both carbon and hetero atoms. RBO_relaxed.owl CHEBI:75763 biolink:NamedThing eukaryotic metabolite Any metabolite produced during a metabolic reaction in eukaryotes, the taxon that include members of the fungi, plantae and animalia kingdoms. RBO_relaxed.owl CHEBI:75787 biolink:NamedThing prokaryotic metabolite Any metabolite produced during a metabolic reaction in prokaryotes, the taxon that include members of domains such as the bacteria and archaea. RBO_relaxed.owl CHEBI:76206 biolink:NamedThing xenobiotic metabolite Any metabolite produced by metabolism of a xenobiotic compound. RBO_relaxed.owl CHEBI:78675 biolink:NamedThing fundamental metabolite Any metabolite produced by all living cells. RBO_relaxed.owl CHEBI:75767 biolink:NamedThing animal metabolite Any eukaryotic metabolite produced during a metabolic reaction in animals that include diverse creatures from sponges, insects to mammals. RBO_relaxed.owl CHEBI:76924 biolink:NamedThing plant metabolite Any eukaryotic metabolite produced during a metabolic reaction in plants, the kingdom that include flowering plants, conifers and other gymnosperms. RBO_relaxed.owl CHEBI:76946 biolink:NamedThing fungal metabolite Any eukaryotic metabolite produced during a metabolic reaction in fungi, the kingdom that includes microorganisms such as the yeasts and moulds. RBO_relaxed.owl CHEBI:84735 biolink:NamedThing algal metabolite Any eukaryotic metabolite produced during a metabolic reaction in algae including unicellular organisms like chlorella and diatoms to multicellular organisms like giant kelps and brown algae. RBO_relaxed.owl CHEBI:75768 biolink:NamedThing mammalian metabolite Any animal metabolite produced during a metabolic reaction in mammals. RBO_relaxed.owl CHEBI:83039 biolink:NamedThing crustacean metabolite An animal metabolite produced by arthropods such as crabs, lobsters, crayfish, shrimps and krill. RBO_relaxed.owl CHEBI:75771 biolink:NamedThing mouse metabolite Any mammalian metabolite produced during a metabolic reaction in a mouse (Mus musculus). RBO_relaxed.owl CHEBI:77746 biolink:NamedThing human metabolite Any mammalian metabolite produced during a metabolic reaction in humans (Homo sapiens). RBO_relaxed.owl CHEBI:75772 biolink:NamedThing Saccharomyces cerevisiae metabolite Any fungal metabolite produced during a metabolic reaction in Baker's yeast (Saccharomyces cerevisiae). RBO_relaxed.owl CHEBI:76759 biolink:NamedThing EC 3.* (hydrolase) inhibitor Any enzyme inhibitor that interferes with the action of a hydrolase (EC 3.*.*.*). RBO_relaxed.owl CHEBI:76764 biolink:NamedThing EC 3.5.* (hydrolases acting on non-peptide C-N bonds) inhibitor Any hydrolase inhibitor that interferes with the action of a hydrolase acting on C-N bonds, other than peptide bonds (EC 3.5.*.*). RBO_relaxed.owl CHEBI:76807 biolink:NamedThing EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor An EC 3.5.* (hydrolases acting on non-peptide C-N bonds) inhibitor that interferes with the action of any non-peptide linear amide C-N hydrolase (EC 3.5.1.*). RBO_relaxed.owl CHEBI:76967 biolink:NamedThing human xenobiotic metabolite Any human metabolite produced by metabolism of a xenobiotic compound in humans. RBO_relaxed.owl CHEBI:76969 biolink:NamedThing bacterial metabolite Any prokaryotic metabolite produced during a metabolic reaction in bacteria. RBO_relaxed.owl CHEBI:76971 biolink:NamedThing Escherichia coli metabolite Any bacterial metabolite produced during a metabolic reaction in Escherichia coli. RBO_relaxed.owl CHEBI:77941 biolink:NamedThing EC 3.5.1.4 (amidase) inhibitor An EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor that interferes with the action of amidase (EC 3.5.1.4). RBO_relaxed.owl CHEBI:78608 biolink:NamedThing alpha-amino acid zwitterion An amino acid zwitterion obtained by transfer of a proton from the carboxy to the amino group of any alpha-amino acid; major species at pH 7.3. RBO_relaxed.owl CHEBI:83056 biolink:NamedThing Daphnia magna metabolite A Daphnia metabolite produced by the species Daphnia magna. RBO_relaxed.owl CHEBI:83057 biolink:NamedThing Daphnia metabolite A crustacean metabolite produced by the genus of small planktonic arthropods, Daphnia RBO_relaxed.owl OBO:CHMO_0002793 biolink:NamedThing sensor A piece of apparatus that is used to measure a physical quantity. RBO_relaxed.owl OBI:0000968 biolink:NamedThing device A material entity that is designed to perform a function in a scientific investigation, but is not a reagent. RBO_relaxed.owl OBI:0001032 biolink:NamedThing light emission device A device which has a function to emit light. RBO_relaxed.owl OBI:0001138 biolink:NamedThing X-ray source A device that is used to generate X-rays. RBO_relaxed.owl OBO:RBO_00000033 biolink:NamedThing spacecraft Vehicles, crewed or uncrewed, which are designed to orbit about the Earth or another celestial body or be placed into a trajectory to another celestial body or location in space. RBO_relaxed.owl OBO:RBO_00000115 biolink:NamedThing radiation dosimeter device A device that is used to measure the amount of ionizing radiation exposure or absorption. RBO_relaxed.owl OBO:RBO_00000121 biolink:NamedThing particle accelerator A device used to impart kinetic energy to subatomic particles by means of electric and magnetic fields RBO_relaxed.owl OBO:RBO_00000122 biolink:NamedThing nuclear reactor A device in which nuclear fission may be initiated and controlled in a self-sustaining chain reaction to generate energy or produce useful radiation. RBO_relaxed.owl OBO:CHMO_0002796 biolink:NamedThing dosimetry Measurement of the dose of a substance taken up by an object. RBO_relaxed.owl OBO:CHMO_0002797 biolink:NamedThing dosimeter A sensor that is used to measure the dose of a substance taken by up an object. RBO_relaxed.owl CL:0000000 biolink:NamedThing cell A material entity of anatomical origin (part of or deriving from an organism) that has as its parts a maximally connected cell compartment surrounded by a plasma membrane.|A material entity that has a plasma membrane and results from cellular division. RBO_relaxed.owl GO:0032991 biolink:NamedThing protein-containing complex A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together. RBO_relaxed.owl GO:0110165 biolink:NamedThing cellular anatomical entity A part of a cellular organism that is either an immaterial entity or a material entity with granularity above the level of a protein complex but below that of an anatomical system. Or, a substance produced by a cellular organism with granularity above the level of a protein complex. RBO_relaxed.owl UBERON:0000061 biolink:NamedThing anatomical structure Material anatomical entity that is a single connected structure with inherent 3D shape generated by coordinated expression of the organism's own genome. RBO_relaxed.owl UBERON:0000045 biolink:NamedThing ganglion A biological tissue mass, most commonly a mass of nerve cell bodies. RBO_relaxed.owl UBERON:0000077 biolink:NamedThing mixed endoderm/mesoderm-derived structure An anatomical structure that develops from the endoderm and the mesoderm. RBO_relaxed.owl UBERON:0000078 biolink:NamedThing mixed ectoderm/mesoderm/endoderm-derived structure An anatomical structure that develops from the ectoderm, mesoderm and endoderm. RBO_relaxed.owl UBERON:0000467 biolink:NamedThing anatomical system Multicellular, connected anatomical structure that has multiple organs as parts and whose parts work together to achieve some shared function. RBO_relaxed.owl UBERON:0000476 biolink:NamedThing acellular anatomical structure Anatomical structure that consists of cell parts and cell substances and together does not constitute a cell or a tissue. RBO_relaxed.owl UBERON:0003037 biolink:NamedThing septum A wall, dividing a cavity or structure into smaller ones[WP]. RBO_relaxed.owl UBERON:0003102 biolink:NamedThing surface structure Anatomical structure that overlaps the outer epithelial layer and is adjacent to the space surrounding the organism. RBO_relaxed.owl UBERON:0004119 biolink:NamedThing endoderm-derived structure An anatomical structure that develops (entirely or partially) from the endoderm. RBO_relaxed.owl UBERON:0004120 biolink:NamedThing mesoderm-derived structure An anatomical structure that develops (entirely or partially) from the mesoderm. RBO_relaxed.owl UBERON:0004121 biolink:NamedThing ectoderm-derived structure An anatomical structure that develops (entirely or partially) from the ectoderm. RBO_relaxed.owl UBERON:0004716 biolink:NamedThing conceptus The embryo and its adnexa (appendages or adjunct parts) or associated membranes (i.e. the products of conception) The conceptus includes all structures that develop from the zygote, both embryonic and extraembryonic. It includes the embryo as well as the embryonic part of the placenta and its associated membranes - amnion, chorion (gestational sac), and yolk sac[WP]. RBO_relaxed.owl UBERON:0005090 biolink:NamedThing muscle structure Muscle structures are contractile cells, tissues or organs that are found in multicellular organisms[GO]. RBO_relaxed.owl UBERON:0005162 biolink:NamedThing multi cell part structure A structure consisting of multiple cell components but which is not itself a cell and does not have (complete) cells as a part. RBO_relaxed.owl UBERON:0005389 biolink:NamedThing transparent eye structure A transparent structure that is part of a visual sense organ, the function of which is to direct or focus light onto a photoreceptor array. RBO_relaxed.owl UBERON:0007651 biolink:NamedThing anatomical junction An anatomical structure that connects two structures. RBO_relaxed.owl UBERON:0009856 biolink:NamedThing sac RBO_relaxed.owl UBERON:0010000 biolink:NamedThing multicellular anatomical structure An anatomical structure that has more than one cell as a part. RBO_relaxed.owl UBERON:0010313 biolink:NamedThing neural crest-derived structure An anatomical structure that develops from the neural crest. RBO_relaxed.owl UBERON:0010314 biolink:NamedThing structure with developmental contribution from neural crest An anatomical structure that has some part that develops from the neural crest. RBO_relaxed.owl UBERON:0011585 biolink:NamedThing cell condensation Anatomical structure that is an aggregation of similar cells from which cartilages and bones form, and from which chondrogenesis and osteogenesis are initiated during repair and/or regeneration. (Hall and Miyake 1995). RBO_relaxed.owl UBERON:0014402 biolink:NamedThing sex-specific anatomical structure A part of the body present only in a specific gender. RBO_relaxed.owl UBERON:0015212 biolink:NamedThing lateral structure Any structure that is placed on one side of the left-right axis of a bilaterian. RBO_relaxed.owl UBERON:0018254 biolink:NamedThing skeletal musculature RBO_relaxed.owl UBERON:0035118 biolink:NamedThing material entity in digestive tract Any material entity that is located in the digestive tract. This includes undigested food and liquid as well as unexcreted waste products. It also includes other entities such as ingested stones used to aid digestion. Any microbial cells or cell populations are also included. RBO_relaxed.owl CL:0000005 biolink:NamedThing fibroblast neural crest derived Any fibroblast that is deriived from the neural crest. RBO_relaxed.owl CL:0000057 biolink:NamedThing fibroblast A connective tissue cell which secretes an extracellular matrix rich in collagen and other macromolecules. Flattened and irregular in outline with branching processes; appear fusiform or spindle-shaped. RBO_relaxed.owl CL:0002240 biolink:NamedThing marrow fibroblast A fibroblast in the bone marrow. RBO_relaxed.owl CL:0002363 biolink:NamedThing keratocyte A keratocyte is a specialized fibroblast residing in the cornea stroma that has a flattened, dendritic morphology; located between the lamellae with a large flattened nucleus, and lengthy processes which communicate with neighboring cells. This corneal layer, representing about 85-90% of corneal thickness, is built up from highly regular collagenous lamellae and extracellular matrix components. Keratocytes play the major role in keeping it transparent, healing its wounds, and synthesizing its components. This cell type secretes collagen I, V, VI, and keratan sulfate. RBO_relaxed.owl CL:0002548 biolink:NamedThing fibroblast of cardiac tissue A fibroblast that is part of the heart. RBO_relaxed.owl CL:0002553 biolink:NamedThing fibroblast of lung A fibroblast that is part of lung. RBO_relaxed.owl CL:0002557 biolink:NamedThing fibroblast of pulmonary artery A fibroblast of pulmonary artery. RBO_relaxed.owl CL:0002620 biolink:NamedThing skin fibroblast A fibroblast of skin. RBO_relaxed.owl CL:0009100 biolink:NamedThing hepatic portal fibroblast A fibroblast located in the portal triad. Hepatic portal fibroblast are a non-parenchymal cell population located adjacent to bile duct epithelia in liver and are distinct from stellate cells. They differentiate into fibrogenic myofibroblasts during chronic injury states producing high levels of collagen. RBO_relaxed.owl CL:0011021 biolink:NamedThing fibroblast of upper back skin A fibroblast that is part of upper back skin. RBO_relaxed.owl CL:0011022 biolink:NamedThing fibroblast of skin of back A fibroblast that is part of skin of back. RBO_relaxed.owl CL:0011027 biolink:NamedThing skeletal muscle fibroblast Any fibroblast that is part of skeletal muscle tissue. RBO_relaxed.owl CL:1000303 biolink:NamedThing fibroblast of areolar connective tissue A fibroblast that is part of the areolar connective tissue. RBO_relaxed.owl CL:1000306 biolink:NamedThing fibroblast of tunica adventitia of artery A fibroblast that is part of the tunica adventitia of artery. RBO_relaxed.owl CL:1000307 biolink:NamedThing fibroblast of dense regular elastic tissue A fibroblast that is part of the dense regular elastic tissue. RBO_relaxed.owl CL:1001609 biolink:NamedThing muscle fibroblast Fibroblast from muscle organ. RBO_relaxed.owl CL:2000042 biolink:NamedThing embryonic fibroblast Any fibroblast that is part of a embryo. RBO_relaxed.owl CL:2000051 biolink:NamedThing splenic fibroblast Any fibroblast that is part of a spleen. RBO_relaxed.owl CL:2000063 biolink:NamedThing ovarian fibroblast Any fibroblast that is part of a female gonad. RBO_relaxed.owl CL:2000066 biolink:NamedThing cardiac ventricle fibroblast Any fibroblast that is part of a cardiac ventricle. RBO_relaxed.owl CL:2000067 biolink:NamedThing cardiac atrium fibroblast Any fibroblast that is part of a cardiac atrium. RBO_relaxed.owl CL:2000068 biolink:NamedThing pericardium fibroblast Any fibroblast that is part of a pericardium. RBO_relaxed.owl CL:2000069 biolink:NamedThing gallbladder fibroblast Any fibroblast that is part of a gallbladder. RBO_relaxed.owl CL:2000070 biolink:NamedThing optic choroid fibroblast Any fibroblast that is part of a optic choroid. RBO_relaxed.owl CL:0000027 biolink:NamedThing smooth muscle cell neural crest derived A smooth muscle cell derived from the neural crest. RBO_relaxed.owl CL:0000029 biolink:NamedThing neural crest derived neuron RBO_relaxed.owl CL:0000333 biolink:NamedThing migratory neural crest cell A cell derived from the specialized ectoderm flanking each side of the embryonic neural plate, which after the closure of the neural tube, forms masses of cells that migrate out from the dorsal aspect of the neural tube to spread throughout the body. RBO_relaxed.owl CL:0000347 biolink:NamedThing scleral cell A cell of the sclera of the eye. RBO_relaxed.owl CL:0000348 biolink:NamedThing choroidal cell of the eye A structural cell that is part of optic choroid. RBO_relaxed.owl CL:0000575 biolink:NamedThing corneal epithelial cell An epithelial cell of the cornea. RBO_relaxed.owl CL:0002333 biolink:NamedThing neural crest derived adipocyte An adipocyte derived from a neural crest cell. RBO_relaxed.owl CL:0002676 biolink:NamedThing neural crest derived neuroblast A neuroblast derived from a neural crest cell. RBO_relaxed.owl UBERON:0000964 biolink:NamedThing cornea The transparent anterior portion of the fibrous coat of the eye that serves as the chief refractory structure. RBO_relaxed.owl UBERON:0001675 biolink:NamedThing trigeminal ganglion The cranial ganglion that is associated with and extends fibers into the trigeminal nerve. RBO_relaxed.owl UBERON:0001697 biolink:NamedThing orbit of skull Subdivision of skeleton that is an anterolateral part of the cranium and structurally supports the eye. Includes bones formed and located in sclerotic layer of eyeball. RBO_relaxed.owl UBERON:0001708 biolink:NamedThing jaw skeleton Subdivision of skeleton which includes upper and lower jaw skeletons. RBO_relaxed.owl UBERON:0001772 biolink:NamedThing corneal epithelium The smooth stratified squamous epithelium that covers the outer surface of the cornea. RBO_relaxed.owl UBERON:0001773 biolink:NamedThing sclera Opaque fibrous outer layer of the eyeball[ZFA,Kardong,WP]. RBO_relaxed.owl UBERON:0001777 biolink:NamedThing substantia propria of cornea The lamellated connective tissue of the cornea between the Bowman and Descemet membranes. RBO_relaxed.owl UBERON:0001806 biolink:NamedThing sympathetic ganglion A ganglion of the sympathetic nervous system. Examples: paravertebral and the prevertebral ganglia, which include the sympathetic chain ganglia, the superior, middle, and inferior cervical ganglia, and the aorticorenal, celiac, and stellate ganglia. RBO_relaxed.owl UBERON:0001985 biolink:NamedThing corneal endothelium A monolayer of specialized, flattened, mitochondria-rich cells that lines the posterior surface of the cornea and faces the anterior chamber of the eye[WP]. RBO_relaxed.owl UBERON:0002443 biolink:NamedThing choroidal blood vessel A blood vessel that is part of a choroid [Automatically generated definition]. RBO_relaxed.owl UBERON:0003277 biolink:NamedThing skeleton of upper jaw A subdivision of the skeleton that corresponds to the upper part of the mouth. The lower jaw skeleton includes the following elements, when present: upper jaw teeth, the maxilla and other lower jaw bones. RBO_relaxed.owl UBERON:0003278 biolink:NamedThing skeleton of lower jaw A subdivision of the skeleton that corresponds to the lower part of the mouth. The lower jaw skeleton includes the following elements, when present: lower jaw teeth, the mandible and other lower jaw bones, and Meckel's cartilage. RBO_relaxed.owl UBERON:0003462 biolink:NamedThing facial bone A bone that is part of a facial skeleton [Automatically generated definition]. RBO_relaxed.owl UBERON:0003500 biolink:NamedThing corneal blood vessel A blood vessel that is part of a cornea [Automatically generated definition]. RBO_relaxed.owl UBERON:0003501 biolink:NamedThing retina blood vessel A blood vessel that is part of a retina [Automatically generated definition]. RBO_relaxed.owl UBERON:0003511 biolink:NamedThing iris blood vessel A blood vessel that is part of a iris [Automatically generated definition]. RBO_relaxed.owl UBERON:0003585 biolink:NamedThing dermis connective tissue A portion of connective tissue that is part of a dermis [Automatically generated definition]. RBO_relaxed.owl UBERON:0003952 biolink:NamedThing anterior stroma of cornea The anterior segment of the lamellated connective tissue layer of the cornea. RBO_relaxed.owl UBERON:0003953 biolink:NamedThing posterior stroma of cornea The posterior segment of the lamellated connective tissue layer of the cornea. RBO_relaxed.owl UBERON:0004367 biolink:NamedThing Descemet's membrane A transparent homogeneous acellular layer found between the substantia propria and the endothelial layer of the cornea[MP]. RBO_relaxed.owl UBERON:0004370 biolink:NamedThing anterior limiting lamina of cornea A transparent homogeneous acellular layer, 6 to 9 um thick, lying between the basal lamina of the outer layer of stratified epithelium and the substantia propria of the cornea; it is considered to be a basement membrane. RBO_relaxed.owl UBERON:0004666 biolink:NamedThing interventricular septum membranous part The membranous portion of the wall between the two lower chambers of the heart. RBO_relaxed.owl UBERON:0005427 biolink:NamedThing corneal primordium Portion of tissue that is part of the eye and gives rise to the mature, fully layered cornea. RBO_relaxed.owl UBERON:0005446 biolink:NamedThing foramen rotundum The foramen rotundum is a circular hole in the sphenoid bone that connects the middle cranial fossa and the pterygopalatine fossa. RBO_relaxed.owl UBERON:0005989 biolink:NamedThing atrioventricular septum The wall of the heart that separates the right atrium and left ventricle; and is located just above the septal cusp of the tricuspid valve. RBO_relaxed.owl UBERON:0006207 biolink:NamedThing aortico-pulmonary spiral septum The spiral septum that separates the truncus arteriosus into a ventral pulmonary trunk and the dorsal aorta[MP]. The aorticopulmonary septum is developmentally formed from neural crest, specifically the cardiac neural crest, and actively separates the aorta and pulmonary arteries and fuses with the interventricular septum within the heart during development. The actual mechanism of septation of the outflow tract is poorly understood, but is recognized as a dynamic process with contributions from contractile, hemodynamic, and extracellular matrix interactions. RBO_relaxed.owl UBERON:0006271 biolink:NamedThing orbital fissure Either of two openings transmitting nerves and blood vessels to or from the orbit. RBO_relaxed.owl UBERON:0010291 biolink:NamedThing layer of sclera RBO_relaxed.owl UBERON:0010321 biolink:NamedThing skeletal element of eye region A skeletal element that is part of a orbital region. RBO_relaxed.owl UBERON:0011085 biolink:NamedThing palatoquadrate arch The dorsal portion of the first pharyngeal arch, comprising the upper jaw[ZFIN,VHOG]. RBO_relaxed.owl UBERON:0011156 biolink:NamedThing facial skeleton Subdivision of skull that consists of the facial bones. RBO_relaxed.owl UBERON:0011865 biolink:NamedThing corneal stroma collagen fibril The connective tissue bundles in the extracellular matrix of corneal stroma that are composed of collagen, and play a role in tissue strength and elasticity. RBO_relaxed.owl UBERON:0014387 biolink:NamedThing mesenchyme derived from neural crest Mesenchyme that develops_from the neural crest[Automatically generated definition]. RBO_relaxed.owl UBERON:0015060 biolink:NamedThing sphenoid endochondral element A sphenoid bone or its cartilage or pre-cartilage precursor. RBO_relaxed.owl UBERON:0018415 biolink:NamedThing ethmoid foramen An bone foramen in the ethmoid bone. RBO_relaxed.owl UBERON:0037089 biolink:NamedThing wall of orbit RBO_relaxed.owl CL:0000006 biolink:NamedThing neuronal receptor cell RBO_relaxed.owl CL:0000101 biolink:NamedThing sensory neuron Any neuron having a sensory function; an afferent neuron conveying sensory impulses. RBO_relaxed.owl CL:0009000 biolink:NamedThing sensory neuron of spinal nerve A sensory neuron of the spinal nerve that senses body position and sends information about how much the muscle is stretched to the spinal cord. RBO_relaxed.owl CL:3000004 biolink:NamedThing peripheral sensory neuron Peripheral sensory neuron. RBO_relaxed.owl CL:0000197 biolink:NamedThing sensory receptor cell A cell that is capable of detection of a stimulus involved in sensory perception. RBO_relaxed.owl CL:0000098 biolink:NamedThing sensory epithelial cell A specialized epithelial cell involved in sensory perception. Restricted to special sense organs of the olfactory, gustatory, and vestibulocochlear receptor systems; contain sensory cells surrounded by supportive, non-receptive cells. RBO_relaxed.owl CL:0000206 biolink:NamedThing chemoreceptor cell A cell specialized to detect chemical substances and relay that information centrally in the nervous system. Chemoreceptors may monitor external stimuli, as in taste and olfaction, or internal stimuli, such as the concentrations of oxygen and carbon dioxide in the blood. RBO_relaxed.owl CL:0000540 biolink:NamedThing neuron The basic cellular unit of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system. RBO_relaxed.owl CL:0000099 biolink:NamedThing interneuron Most generally any neuron which is not motor or sensory. Interneurons may also refer to neurons whose axons remain within a particular brain region as contrasted with projection neurons which have axons projecting to other brain regions. RBO_relaxed.owl CL:0000107 biolink:NamedThing autonomic neuron A neuron whose cell body is within an autonomic ganglion. RBO_relaxed.owl CL:0000108 biolink:NamedThing cholinergic neuron A neuron that uses acetylcholine as a vesicular neurotransmitter. RBO_relaxed.owl CL:0000117 biolink:NamedThing CNS neuron (sensu Vertebrata) RBO_relaxed.owl CL:0000165 biolink:NamedThing neuroendocrine cell A neuron that is capable of some hormone secretion in response to neuronal signals. RBO_relaxed.owl CL:0000210 biolink:NamedThing photoreceptor cell A cell specialized to detect and transduce light. RBO_relaxed.owl CL:0000526 biolink:NamedThing afferent neuron A neuron which conveys sensory information centrally from the periphery. RBO_relaxed.owl CL:0000527 biolink:NamedThing efferent neuron A neuron which sends impulses peripherally to activate muscles or secretory cells. RBO_relaxed.owl CL:0000850 biolink:NamedThing serotonergic neuron A neuron that releases serotonin as a neurotransmitter. RBO_relaxed.owl CL:0008025 biolink:NamedThing noradrenergic neuron A neuron that release noradrenaline (noriphinephrine) as a neurotransmitter. RBO_relaxed.owl CL:0008028 biolink:NamedThing visual system neuron RBO_relaxed.owl CL:0010022 biolink:NamedThing cardiac neuron A neuron that has its soma in the heart. RBO_relaxed.owl CL:2000029 biolink:NamedThing central nervous system neuron Any neuron that is part of a central nervous system. RBO_relaxed.owl CL:2000032 biolink:NamedThing peripheral nervous system neuron A neuron that is part of a peripheral nervous system. RBO_relaxed.owl CL:4023079 biolink:NamedThing midbrain-derived inhibitory neuron A GABAergic inhibitory neuron that is derived from the midbrain. RBO_relaxed.owl CL:4023168 biolink:NamedThing somatosensory neuron A neuron that is part of the somatic sensory system. Somatosensory neurons innervate the skin or integument to detect different types of thermal, chemical, and mechanical touch stimuli. RBO_relaxed.owl CL:4033050 biolink:NamedThing catecholaminergic neuron A neuron that releases catecholamine as a neurotransmitter. RBO_relaxed.owl CL:0000007 biolink:NamedThing early embryonic cell (metazoa) A cell found in the embryo before the formation of all the gem layers is complete. RBO_relaxed.owl CL:0002321 biolink:NamedThing embryonic cell (metazoa) A cell of the embryo. RBO_relaxed.owl CL:0000221 biolink:NamedThing ectodermal cell A cell of the outer of the three germ layers of the embryo. RBO_relaxed.owl CL:0000222 biolink:NamedThing mesodermal cell A cell of the middle germ layer of the embryo. RBO_relaxed.owl CL:0000223 biolink:NamedThing endodermal cell A cell of the inner of the three germ layers of the embryo. RBO_relaxed.owl CL:0011012 biolink:NamedThing neural crest cell A cell of the neural crest. Neural crest cells are multipotent. Premigratory neural crest cells are found at the neural plate boarder, some of which will undergo ectomesynchymal transition and delamination to form migratory neural crest cells. RBO_relaxed.owl CL:0000008 biolink:NamedThing migratory cranial neural crest cell Cell that is part of the migratory cranial neural crest population. Migratory cranial neural crest cells develop from premigratory cranial neural crest cells and have undergone epithelial to mesenchymal transition and delamination. RBO_relaxed.owl CL:0000011 biolink:NamedThing migratory trunk neural crest cell Cell that is part of the migratory trunk neural crest population. Migratory trunk neural crest cells develop from premigratory trunk neural crest cells and have undergone epithelial to mesenchymal transition and delamination. RBO_relaxed.owl CL:2000073 biolink:NamedThing migratory cardiac neural crest cell Any migratory neural crest cell that is part of a cardiac neural crest. RBO_relaxed.owl CL:0000014 biolink:NamedThing germ line stem cell A stem cell that is the precursor of gametes. RBO_relaxed.owl CL:0000034 biolink:NamedThing stem cell A relatively undifferentiated cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells. RBO_relaxed.owl CL:0000048 biolink:NamedThing multi fate stem cell A stem cell that can give rise to multiple lineages of cells. RBO_relaxed.owl CL:0000723 biolink:NamedThing somatic stem cell A stem cell that can give rise to cell types of the body other than those of the germ-line. RBO_relaxed.owl CL:0000039 biolink:NamedThing germ line cell A cell that is within the developmental lineage of gametes and is able to pass along its genetic material to offspring. RBO_relaxed.owl CL:0000586 biolink:NamedThing germ cell The reproductive cell in multicellular organisms. RBO_relaxed.owl CL:0000670 biolink:NamedThing primordial germ cell A primordial germ cell is a diploid germ cell precursors that transiently exist in the embryo before they enter into close association with the somatic cells of the gonad and become irreversibly committed as germ cells. RBO_relaxed.owl CL:0000021 biolink:NamedThing female germ cell Female germ cell is a germ cell that supports female gamete production. RBO_relaxed.owl CL:0000300 biolink:NamedThing gamete A mature sexual reproductive cell having a single set of unpaired chromosomes. RBO_relaxed.owl CL:0000022 biolink:NamedThing female germ line stem cell A stem cell that is the precursor of female gametes. RBO_relaxed.owl CL:0000023 biolink:NamedThing oocyte A female germ cell that has entered meiosis. RBO_relaxed.owl CL:0000024 biolink:NamedThing oogonial cell An undifferentiated germ cell that proliferates rapidly and gives rise to oocytes. RBO_relaxed.owl CL:0000675 biolink:NamedThing female gamete A mature sexual reproductive cell of the female germline. RBO_relaxed.owl CL:0000255 biolink:NamedThing eukaryotic cell RBO_relaxed.owl CL:0000031 biolink:NamedThing neuroblast (sensu Vertebrata) A cell that will develop into a neuron often after a migration phase. RBO_relaxed.owl CL:0000257 biolink:NamedThing Eumycetozoan cell RBO_relaxed.owl CL:0000365 biolink:NamedThing animal zygote Diploid cell produced by the fusion of sperm cell nucleus and egg cell. RBO_relaxed.owl CL:0000521 biolink:NamedThing fungal cell RBO_relaxed.owl CL:0000738 biolink:NamedThing leukocyte An achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue. RBO_relaxed.owl OBO:CARO_0000000 biolink:NamedThing RBO_relaxed.owl CL:0000025 biolink:NamedThing egg cell A female gamete where meiosis has progressed to metaphase II and is able to participate in fertilization. RBO_relaxed.owl CL:0000058 biolink:NamedThing chondroblast Skeletogenic cell that is typically non-terminally differentiated, secretes an avascular, GAG rich matrix; is not buried in cartilage tissue matrix, retains the ability to divide, located adjacent to cartilage tissue (including within the perichondrium), and develops from prechondroblast (and thus prechondrogenic) cell. RBO_relaxed.owl CL:0000136 biolink:NamedThing adipocyte A fat-storing cell found mostly in the abdominal cavity and subcutaneous tissue of mammals. Fat is usually stored in the form of triglycerides. RBO_relaxed.owl CL:0000499 biolink:NamedThing stromal cell A connective tissue cell of an organ found in the loose connective tissue. These are most often associated with the uterine mucosa and the ovary as well as the hematopoietic system and elsewhere. RBO_relaxed.owl CL:0000763 biolink:NamedThing myeloid cell A cell of the monocyte, granulocyte, mast cell, megakaryocyte, or erythroid lineage. RBO_relaxed.owl CL:0000837 biolink:NamedThing hematopoietic multipotent progenitor cell A hematopoietic multipotent progenitor cell is multipotent, but not capable of long-term self-renewal. These cells are characterized as lacking lineage cell surface markers and being CD34-positive in both mice and humans. RBO_relaxed.owl CL:0002031 biolink:NamedThing hematopoietic lineage restricted progenitor cell A hematopoietic progenitor cell that is capable of developing into only one lineage of hematopoietic cells. RBO_relaxed.owl CL:0002032 biolink:NamedThing hematopoietic oligopotent progenitor cell A hematopoietic oligopotent progenitor cell that has the ability to differentiate into limited cell types but lacks lineage cell markers and self renewal capabilities. RBO_relaxed.owl CL:0005024 biolink:NamedThing somatomotor neuron A motor neuron that innervates a skeletal muscle. These motor neurons are all excitatory and cholinergic. RBO_relaxed.owl CL:0011026 biolink:NamedThing progenitor cell A precursor cell that has a tendency to differentiate into a specific type of cell. They are descendants of stem cells, only they are more constrained in their differentiation potential or capacity for self-renewal, and are often more limited in both senses. RBO_relaxed.owl CL:2000047 biolink:NamedThing brainstem motor neuron Any motor neuron that is part of a brainstem. RBO_relaxed.owl ENVO:01000338 biolink:NamedThing litter layer RBO_relaxed.owl ENVO:01000628 biolink:NamedThing plant litter Leaf litter is dead plant material, such as leaves, bark, needles, and twigs, that has fallen to the ground. RBO_relaxed.owl PO:0005029 biolink:NamedThing root primordium A primordium (PO:0025127) that develops from a root anlagen (PO:0025433) and is committed to the development of a root (PO:0009005). RBO_relaxed.owl PO:0006001 biolink:NamedThing phyllome A lateral plant organ (PO:0009008) produced by a shoot apical meristem (PO:0020148). RBO_relaxed.owl PO:0009005 biolink:NamedThing root A plant axis (PO:0025004) that lacks shoot axis nodes (PO:0005004) and usually grows indeterminately. RBO_relaxed.owl PO:0025128 biolink:NamedThing phyllome primordium A primordium (PO:0025127) that develops from a phyllome anlagen (PO:0025430) and is part of a shoot apex (PO:0000037) and is committed to the development of a phyllome (PO:0006001). RBO_relaxed.owl UBERON:0000087 biolink:NamedThing inner cell mass A mass of cells that develop into the body of the embryo and some extraembryonic tissues. RBO_relaxed.owl UBERON:0000088 biolink:NamedThing trophoblast The mesectodermal cell layer arising from the trophectoderm that erodes the uterine mucosa and contributes to the formation of the placenta. RBO_relaxed.owl UBERON:0000091 biolink:NamedThing bilaminar disc A flattened, almost circular bilaminar plate of cells formed when the inner cell mass (aka embryoblast) forms two epithelial layers, each of a distinct lineage, separated by an extracellular basement membrane: the external (dorsal) layer is called the epiblast and the internal (ventral) layer is called the hypoblast (aka primitive endoderm); together, they compose the bilaminar embryonic disc. RBO_relaxed.owl UBERON:0000163 biolink:NamedThing embryonic cloaca Endoderm-lined chamber that develops as pouch-like dilation of the caudal end of the hindgut and receives the allantois ventrally and two mesonephric ducts laterally; caudally it ends blindly at the cloacal membrane formed by the union of proctodeal (anal pit) ectoderm and cloacal endoderm, with no intervening mesoderm[MP]. RBO_relaxed.owl UBERON:0000165 biolink:NamedThing mouth The proximal portion of the digestive tract, containing the oral cavity and bounded by the oral opening. In vertebrates, this extends to the pharynx and includes gums, lips, tongue and parts of the palate. Typically also includes the teeth, except where these occur elsewhere (e.g. pharyngeal jaws) or protrude from the mouth (tusks). RBO_relaxed.owl UBERON:0000170 biolink:NamedThing pair of lungs The pair of anatomical structures comprised of a left lung and right lung. RBO_relaxed.owl UBERON:0000178 biolink:NamedThing blood A fluid that is composed of blood plasma and erythrocytes. RBO_relaxed.owl UBERON:0000304 biolink:NamedThing tendon sheath A layer of membrane around a tendon. It has 2 layers: synovial sheath + fibrous tendon sheath. RBO_relaxed.owl UBERON:0000307 biolink:NamedThing blastula Organism at the blastula stage - an early stage of embryonic development in animals. It is produced by cleavage of a fertilized ovum and consists of a spherical layer of around 128 cells surrounding a central fluid-filled cavity called the blastocoel. The blastula follows the morula and precedes the gastrula in the developmental sequence. RBO_relaxed.owl UBERON:0000358 biolink:NamedThing blastocyst The mammalian blastocyst is a hollow ball of cells containing two cell types, the inner cell mass and the trophectoderm[GO]. RBO_relaxed.owl UBERON:0000383 biolink:NamedThing musculature of body The subdivision of the musculoskeletal system that consists of all the muscles of the body[VSAO, modified]. RBO_relaxed.owl UBERON:0000931 biolink:NamedThing proctodeum Inward fold on the surface of the embryonic ectoderm that develops into an ectodermal terminal part of the digestive tract. RBO_relaxed.owl UBERON:0000990 biolink:NamedThing reproductive system Anatomical system that has as its parts the organs concerned with reproduction. RBO_relaxed.owl UBERON:0000991 biolink:NamedThing gonad Reproductive organ that produces and releases eggs (ovary) or sperm (testis). RBO_relaxed.owl UBERON:0001013 biolink:NamedThing adipose tissue Portion of connective tissue composed of adipocytes enmeshed in areolar tissue. RBO_relaxed.owl UBERON:0001015 biolink:NamedThing musculature A subdivision of the muscular system corresponding to a subdisivision of an organism. RBO_relaxed.owl UBERON:0001016 biolink:NamedThing nervous system The nervous system is an organ system containing predominantly neuron and glial cells. In bilaterally symmetrical organism, it is arranged in a network of tree-like structures connected to a central body. The main functions of the nervous system are to regulate and control body functions, and to receive sensory input, process this information, and generate behavior [CUMBO]. RBO_relaxed.owl UBERON:0001040 biolink:NamedThing yolk sac A sac-like expansion of the ventral wall of the intestine, narrowed into a yolk stalk near the body[Hyman's]. Membranous sac attached to an embryo, providing early nourishment in the form of yolk in bony fishes, sharks, reptiles, birds, and primitive mammals. It functions as the developmental circulatory system of the human embryo, before internal circulation begins. In the mouse, the yolk sac is the first site of blood formation, generating primitive macrophages and erythrocytes[WP]. RBO_relaxed.owl UBERON:0001042 biolink:NamedThing chordate pharynx A portion of the respiratory and digestive tracts; its distal limit is the superior part of the esophagus and it connects the nasal and oral cavities with the esophagus and larynx; it contains the valleculae and the pyriform recesses; its upper limits are the nasal cavity and cranial base.[FEED]. RBO_relaxed.owl UBERON:0001043 biolink:NamedThing esophagus Tube that connects the pharynx to the stomach. In mammals, the oesophagus connects the buccal cavity with the stomach. The stratified squamous non-keratinised epithelium lining the buccal cavity is continued through the pharynx down into the oesophagus. The lowest part of the oesophagus (ca. 2 cm) is lined with gastric mucosa and covered by peritoneum. The main body of the oesophagus is lined with small, simple mucous glands. Each gland opens into the lumen by a long duct which pierces the muscularis mucosae (Wilson and Washington, 1989). A sphincter is situated at the point where the oesophagus enters the stomach to prevent gastro-oesophageal reflux, i.e. to prevent acidic gastric contents from reaching stratified epithelia of the oesophagus, where they can cause inflammation and irritation (Wilson and Washington, 1989; Brown et al., 1993). RBO_relaxed.owl UBERON:0001046 biolink:NamedThing hindgut The caudalmost subdivision of a digestive tract. RBO_relaxed.owl UBERON:0001130 biolink:NamedThing vertebral column Subdivision of skeletal system that consists of all the vertebra and associated skeletal elements and joints in the body[modified from VSAO]. RBO_relaxed.owl UBERON:0001159 biolink:NamedThing sigmoid colon The part of the large intestine that is closest to the rectum and anus. It forms a loop that averages about 40 cm. in length, and normally lies within the pelvis, but on account of its freedom of movement it is liable to be displaced into the abdominal cavity. RBO_relaxed.owl UBERON:0001165 biolink:NamedThing pyloric antrum The area at the bottom of the stomach on the caudal side of the pyloric canal that contains gastrin-producing G cells, which stimulate acid production, and the luminal pH-sensitive population of somatostatin-producing D cells. RBO_relaxed.owl UBERON:0001166 biolink:NamedThing pylorus The stomach tissue region surrounding and controlling the distal outlet of the stomach, which opens into the duodenum. RBO_relaxed.owl UBERON:0001179 biolink:NamedThing peritoneal cavity Anatomical cavity bounded by visceral and parietal peritoneum. RBO_relaxed.owl UBERON:0001213 biolink:NamedThing intestinal villus The tiny hair-like projections that protrude from the inside of the small intestine that contain blood vessels that capture digested nutrients that are absorbed through the intestinal wall; the villi increase the absorptive surface area of the small intestine by approximately 30-fold. RBO_relaxed.owl UBERON:0001264 biolink:NamedThing pancreas An endoderm derived structure that produces precursors of digestive enzymes and blood glucose regulating hormones[GO]. RBO_relaxed.owl UBERON:0001271 biolink:NamedThing pelvic girdle region The organism subdivision that includes the pelvic girdle skeleton and associated soft tissue. Note that this includes both the skeletal elements and associated tissues (integument, muscle, etc). Examples: There are only two instances in an organism, right and left pelvic girdle regions. RBO_relaxed.owl UBERON:0001353 biolink:NamedThing anal region The anus and surrounding regions. Encompasses both internal and external regions, where present. RBO_relaxed.owl UBERON:0001456 biolink:NamedThing face A subdivision of the head that has as parts the layers deep to the surface of the anterior surface, including the mouth, eyes, and nose (when present). In vertebrates, this includes the facial skeleton and structures superficial to the facial skeleton (cheeks, mouth, eyeballs, skin of face, etc). RBO_relaxed.owl UBERON:0001474 biolink:NamedThing bone element Skeletal element that is composed of bone tissue. RBO_relaxed.owl UBERON:0001484 biolink:NamedThing articular capsule An articular capsule (or joint capsule) is an envelope surrounding a synovial joint. [WP,unvetted]. RBO_relaxed.owl UBERON:0001555 biolink:NamedThing digestive tract A tube extending from the mouth to the anus. RBO_relaxed.owl UBERON:0001703 biolink:NamedThing neurocranium Subdivision of skeletal system that surrounds and protects the brain. Includes the skull base, sensory capsules and the central part of the skull roof. RBO_relaxed.owl UBERON:0001731 biolink:NamedThing cavity of pharynx An anatomical space that is enclosed by a pharynx. RBO_relaxed.owl UBERON:0001785 biolink:NamedThing cranial nerve Cranial nerves are nerves that emerge directly from the brain, in contrast to spinal nerves, which emerge from segments of the spinal cord. RBO_relaxed.owl UBERON:0001834 biolink:NamedThing upper lip Lip that covers the upper portion of the mouth.[TAO]. RBO_relaxed.owl UBERON:0001835 biolink:NamedThing lower lip Lip that covers the lower portion of the mouth.[TAO]. RBO_relaxed.owl UBERON:0002090 biolink:NamedThing postcranial axial skeleton The postcranial subdivision of skeleton structural components forming the long axis of the vertebrate body; in Danio, consisting of the notochord, vertebrae, ribs, supraneurals, intermuscular bones, and unpaired median fins; in human consists of the bones of the vertebral column, the thoracic cage and the pelvis[ZFA+FMA]. RBO_relaxed.owl UBERON:0002199 biolink:NamedThing integument The dermis, epidermis and hypodermis. RBO_relaxed.owl UBERON:0002203 biolink:NamedThing vasculature of eye Vasculature that is part of the eye region. RBO_relaxed.owl UBERON:0002204 biolink:NamedThing musculoskeletal system Anatomical system that consists of the muscular and skeletal systems. RBO_relaxed.owl UBERON:0002213 biolink:NamedThing cartilaginous joint Nonsynovial joint in which the articulating bones or cartilages are connected by cartilage. Examples: Spheno-occipital synchondrosis, first sternocostal joint, pubic symphysis.[FMA]. RBO_relaxed.owl UBERON:0002294 biolink:NamedThing biliary system Organ system subdivision that consists of the organs and ducts that are involved in the production and transportation of bile. In most species this is the gallbladder and the bile ducts (biliary tree). RBO_relaxed.owl UBERON:0002323 biolink:NamedThing coelemic cavity lumen The cavity within the body of all animals higher than the coelenterates and certain primitive worms, formed by the splitting of the embryonic mesoderm into two layers. In mammals it forms the peritoneal, pleural, and pericardial cavities. RBO_relaxed.owl UBERON:0002329 biolink:NamedThing somite Somites are spheres of epithelial cells that form sequentially along the anterior-posterior axis of the embryo through mesenchymal to epithelial transition of the presomitic mesoderm. RBO_relaxed.owl UBERON:0002355 biolink:NamedThing pelvic region of trunk The lower segment of the trunk, inferioposterior to the abdomen proper, in the transition area between the trunk and the lower limbs. RBO_relaxed.owl UBERON:0002359 biolink:NamedThing fibrous pericardium Membrane organ which is attached to the pericardial sac proper and the central tendon of diaphragm and is continuous with the pretracheal fascia.[FMA]. RBO_relaxed.owl UBERON:0002402 biolink:NamedThing pleural cavity The fluid-filled cavity that lies between the visceral and parietal pleurae. RBO_relaxed.owl UBERON:0002407 biolink:NamedThing pericardium The combination of pericardial sac (a double-walled sac containing the heart and the roots of the great vessels) plus fibrous pericardium. RBO_relaxed.owl UBERON:0002416 biolink:NamedThing integumental system Connected anatomical system that forms a barrier between an animal and its environment. In vertebrates, the integumental system consists of the epidermis, dermis plus associated glands and adnexa such as hair and scales. In invertebrates, the integumental system may include cuticle. RBO_relaxed.owl UBERON:0002423 biolink:NamedThing hepatobiliary system The part of the digestive system that contains the liver and the biliary system. RBO_relaxed.owl UBERON:0002523 biolink:NamedThing tunica intima The innermost layer of a blood vessel which is a lining of endothelial cells facing the lumen[Kardong]. RBO_relaxed.owl UBERON:0003063 biolink:NamedThing prechordal plate A horseshoe-shaped thickening of the endoderm at the cranial (rostral) end of the primitive streak formed by the involution of Spemann's organizer cells which, together with the notochord, induces the formation of the neural plate from the overlying ectodermal cells and contributes mesodermal type cells to the surrounding tissue. RBO_relaxed.owl UBERON:0003064 biolink:NamedThing intermediate mesoderm The intermediate mesoderm is located between the lateral mesoderm and the paraxial mesoderm. It develops into the kidney and gonads. RBO_relaxed.owl UBERON:0003068 biolink:NamedThing axial mesoderm The axial mesoderm includes the prechordal mesoderm and the chordamesoderm. It gives rise to the prechordal plate and to the notochord. RBO_relaxed.owl UBERON:0003076 biolink:NamedThing posterior neural tube RBO_relaxed.owl UBERON:0003080 biolink:NamedThing anterior neural tube RBO_relaxed.owl UBERON:0003082 biolink:NamedThing myotome A transitional population of migrating mesenchymal cells that derive from somites and that will become muscle cells. RBO_relaxed.owl UBERON:0003084 biolink:NamedThing heart primordium Bilateral groups of cells consisting of three rows: one row of endocardial precursors medially and two rows of myocardical precursors laterally. The two populations fuse at the midline to form the heart rudiment or cone. RBO_relaxed.owl UBERON:0003323 biolink:NamedThing mesenchyme of upper jaw Mesenchyme that is part of a developing upper jaw [Automatically generated definition]. RBO_relaxed.owl UBERON:0003324 biolink:NamedThing mesenchyme of lower jaw Mesenchyme that is part of a developing lower jaw [Automatically generated definition]. RBO_relaxed.owl UBERON:0003566 biolink:NamedThing head connective tissue A portion of connective tissue that is part of a head [Automatically generated definition]. RBO_relaxed.owl UBERON:0003714 biolink:NamedThing neural tissue Portion of tissue in the nervous system which consists of neurons and glial cells, and may also contain parts of the vasculature. RBO_relaxed.owl UBERON:0003886 biolink:NamedThing future coelemic cavity lumen An anatomical cavity that has the potential to develop into a coelemic cavity lumen. RBO_relaxed.owl UBERON:0003887 biolink:NamedThing intraembryonic coelom The part of the coelom in the embryo between the somatopleuric and splanchnopleuric mesoderm; the principal body cavities of the trunk (thoracic, abdominal, and pelvic) arise from this embryonic part of the coelom. RBO_relaxed.owl UBERON:0004016 biolink:NamedThing dermatome A transitional population of migrating mesenchymal cells that derive from somites and that will become dermal cells. RBO_relaxed.owl UBERON:0004068 biolink:NamedThing medial nasal prominence The central area of the two limbs of a horseshoe-shaped mesenchymal swelling that lie medial to the olfactory placode or pit in the future nasal region of the embryo; it joins with the ipsilateral maxillary prominence in the formation of half of the upper jaw, and the nasal tip and philtrum of the upper lip develop from it. RBO_relaxed.owl UBERON:0004122 biolink:NamedThing genitourinary system Anatomical system that has as its parts the organs concerned with the production and excretion of urine and those concerned with reproduction. RBO_relaxed.owl UBERON:0004139 biolink:NamedThing cardiogenic plate The first recognizable structure derived from the heart field. RBO_relaxed.owl UBERON:0004290 biolink:NamedThing dermomyotome The bilaminar epithelium formed from the myotome and dermatome. RBO_relaxed.owl UBERON:0004345 biolink:NamedThing trophectoderm Outermost layer of cells in the blastodermic vesicle, which will develop into the trophoblast layer and then contact the endometrium and take part in establishing the embryo's means of nutrition. RBO_relaxed.owl UBERON:0004455 biolink:NamedThing neurula embryo An embryo at the neurula stage. RBO_relaxed.owl UBERON:0004535 biolink:NamedThing cardiovascular system Anatomical system that has as its parts the heart and blood vessels. RBO_relaxed.owl UBERON:0004537 biolink:NamedThing blood vasculature A vascular network consisting of blood vessels. RBO_relaxed.owl UBERON:0004572 biolink:NamedThing arterial system The part of the cardiovascular system consisting of all arteries. RBO_relaxed.owl UBERON:0004582 biolink:NamedThing venous system The part of the cardiovascular system consisting of all venous vessels. In vertebrates with a double circulation, this can be divided into systemic and pulmonary portions. RBO_relaxed.owl UBERON:0004708 biolink:NamedThing paired limb/fin An appendage that is part of an appendage girdle complex. RBO_relaxed.owl UBERON:0004734 biolink:NamedThing gastrula Organism at the gastrula stage. RBO_relaxed.owl UBERON:0004755 biolink:NamedThing skeletal tissue A specialized form of connective tissue in which the extracellular matrix is firm, providing the tissue with resilience, and/or mineralized and that functions in mechanical and structural support.[VSAO]. RBO_relaxed.owl UBERON:0004761 biolink:NamedThing cartilaginous neurocranium The primitive cartilagionous skeletal structure of the fetal skull that grows to envelop the rapidly growing embyonic brain. In humans, the chondrocranium begins forming at 28 days from mesenchymal condensations and is fully formed between week 7 and 9 of fetal development. While the majority of the chondrocranium is succeeded by the bony skull in most higher vertebrates, some components do persist into adulthood.[1] In Cartilagious fishes and Agnathans, the chondrocranium persist throughout life.[2] Embryologically, the chondrocranium represent the basal cranial structure, and lay the base for the formation of the endocranium in higher vertebrates[WP]. RBO_relaxed.owl UBERON:0004907 biolink:NamedThing lower digestive tract The region of the digestive tract extending from the beginning of the intestines to the anus[GO - gut definition]. RBO_relaxed.owl UBERON:0004908 biolink:NamedThing upper digestive tract The region of the digestive tract extending from the mouth cavity through pharynx esophagus stomach and duodenum. RBO_relaxed.owl UBERON:0005421 biolink:NamedThing pectoral appendage apical ectodermal ridge An apical ectodermal ridge that is part of a pectoral appendage bud. RBO_relaxed.owl UBERON:0005422 biolink:NamedThing pelvic appendage apical ectodermal ridge An apical ectodermal ridge that is part of a pelvic appendage bud. RBO_relaxed.owl UBERON:0005564 biolink:NamedThing gonad primordium Portion of tissue that gives rise to the immature gonad. RBO_relaxed.owl UBERON:0005597 biolink:NamedThing lung primordium A pair of lateral diverticula just over the liver rudiment representing the primordia of the lungs, formed by the floor of the foregut just anterior to the liver diverticulum. RBO_relaxed.owl UBERON:0005867 biolink:NamedThing mandibular prominence The paired ventral prominences formed by bifurcation of the first pharyngeal arches in the embryo; the two prominences unite ventrally and fuse to form the mandible and lower lip. RBO_relaxed.owl UBERON:0005868 biolink:NamedThing maxillary prominence The paired dorsal prominences formed by bifurcation of the first pharyngeal arches in the embryo that unite with the ipsilateral medial nasal process to form the upper jaw. RBO_relaxed.owl UBERON:0005906 biolink:NamedThing serous sac Organ with organ cavity, which has as parts a serous membrane and a serous cavity . Examples: pleural sac, pericardial sac, tendon sheath, bursa.[FMA]. RBO_relaxed.owl UBERON:0005913 biolink:NamedThing zone of bone organ RBO_relaxed.owl UBERON:0005944 biolink:NamedThing axial skeleton plus cranial skeleton Subdivision of skeleton which consists of cranial skeleton, set of all vertebrae, set of all ribs and sternum[FMA, modified]. RBO_relaxed.owl UBERON:0006211 biolink:NamedThing buccopharyngeal membrane The thin bilaminar membrane derived from the prechordal plate that is devoid of mesoderm and formed by the apposition of the stomodeal ectoderm with the foregut endoderm; after the embryonic head fold has evolved it lies at the caudal limit of the stomodeum, forming a septum between the primitive mouth and pharynx; the membrane eventually disappears, and thus a communication is established between the mouth and the future pharynx. RBO_relaxed.owl UBERON:0006227 biolink:NamedThing ethmoid bone primordium RBO_relaxed.owl UBERON:0006236 biolink:NamedThing tetrapod frontal bone primordium RBO_relaxed.owl UBERON:0006268 biolink:NamedThing notochordal process A midline cellular cord formed from the migration of mesenchymal cells from the primitive knot. RBO_relaxed.owl UBERON:0006598 biolink:NamedThing presumptive structure Portion of embryonic tissue determined by fate mapping to become a structure. RBO_relaxed.owl UBERON:0006815 biolink:NamedThing areolar connective tissue Loose connective tissue located at the outer and inner layers of organs. Examples: submucosal connective tissue, tunica adventitia of artery, papillary dermis, superficial fascia of dorsum of hand. RBO_relaxed.owl UBERON:0006866 biolink:NamedThing terminal part of digestive tract The distalmost portion of the digestive tract, derived from the hindgut, and terminating with the anus. RBO_relaxed.owl UBERON:0006960 biolink:NamedThing ovary stroma The stroma of the ovary is a peculiar soft tissue, abundantly supplied with blood vessels, consisting for the most part of spindle-shaped cells with a small amount of ordinary connective tissue. These cells have been regarded by some anatomists as unstriped muscle cells, which, indeed, they most resemble; by others as connective-tissue cells. On the surface of the organ this tissue is much condensed, and forms a layer composed of short connective-tissue fibers, with fusiform cells between them. The stroma of the ovary may contain interstitial cells resembling those of the testis. RBO_relaxed.owl UBERON:0006965 biolink:NamedThing vascular cord The vascular cord is the primordial vasculature that will develop into blood vessels by the process of tubulogenesis[GO]. The vascular cord is composed of angioblast or vascular endothelial cells in a solid linear mass called a cord. The cord then undergoes tubulogenesis to form the lumen of the vessels[ZFA]. RBO_relaxed.owl UBERON:0007144 biolink:NamedThing embryonic post-anal tail An embryonic structure that will either develop into a post-anal tail or recede into a vestigial remnant of the tail. RBO_relaxed.owl UBERON:0007524 biolink:NamedThing dense mesenchyme tissue Mesenchyme with little extracellular matrix. RBO_relaxed.owl UBERON:0007779 biolink:NamedThing transudate Any bodily fluid that has passed through a membrane such as the capillary wall, as a result of unbalanced hydrostatic and osmotic forces. RBO_relaxed.owl UBERON:0007812 biolink:NamedThing post-anal tail A tail that extends from the posterior tip of the organism to the anus, contains muscle and skeleton. RBO_relaxed.owl UBERON:0007844 biolink:NamedThing cartilage element Skeletal element that is composed of cartilage tissue and may be permanent or transient. RBO_relaxed.owl UBERON:0007845 biolink:NamedThing regular connective tissue Connective tissue, which consists of fibroblasts, the intercellular matrix of which contains a regular network of collagen and elastic fiber bundles. Examples: bone (tissue), cartilage (tissue), dense regular connective tissue. RBO_relaxed.owl UBERON:0008780 biolink:NamedThing inner cell mass derived epiblast An embryonic structure that is derived from the inner cell mass and lies above the hypoblast and gives rise to the three primary germ layers. RBO_relaxed.owl UBERON:0008886 biolink:NamedThing pulmonary vascular system The part of the cardiovascular system consisting of all pulmonary arteries and all pulmonary veins. RBO_relaxed.owl UBERON:0008895 biolink:NamedThing splanchnocranium Subdivision of endoskeleton derived from pharyngeal arches. RBO_relaxed.owl UBERON:0008947 biolink:NamedThing respiratory primordium RBO_relaxed.owl UBERON:0009142 biolink:NamedThing entire embryonic mesenchyme Sum total of mesenchyme in the embryo. RBO_relaxed.owl UBERON:0009576 biolink:NamedThing medulla oblongata sulcus limitans A sulcus limitans of neural tube that is part of a future medulla oblongata. RBO_relaxed.owl UBERON:0009670 biolink:NamedThing rectal lumen An anatomical space that surrounded_by a rectum. RBO_relaxed.owl UBERON:0009955 biolink:NamedThing neurogenic placode Cranial ectodermal placode with potential to develop into a component of the nervous system, such as nerves or ganglia. RBO_relaxed.owl UBERON:0010009 biolink:NamedThing aggregate regional part of brain A regional part of brain consisting of multiple brain regions that are not related through a simple volummetric part of hierarchy, e.g., basal ganglia[NIF]. RBO_relaxed.owl UBERON:0010083 biolink:NamedThing future dermis Mesenchyme that has the potential to develop into a dermis. RBO_relaxed.owl UBERON:0010190 biolink:NamedThing pair of dorsal aortae The paired arterial structures of the embryo that supplies each developing somite via efferent segmental arteries; the dorsal aortae articulate with the umbilical arteries, which return mixed blood to the villi of the chorion for reoxygenation. RBO_relaxed.owl UBERON:0010299 biolink:NamedThing scleral mesenchyme Mesenchyme surrounding the developing optic cup which develops into the sclera. RBO_relaxed.owl UBERON:0010312 biolink:NamedThing immature eye Developing anatomical structure that develops into the eyeball and associated structures. RBO_relaxed.owl UBERON:0010316 biolink:NamedThing germ layer / neural crest RBO_relaxed.owl UBERON:0010709 biolink:NamedThing pelvic complex Appendage girdle complex that when present, encompasses the pelvic appendicular skeleton and the pelvic girdle. RBO_relaxed.owl UBERON:0010913 biolink:NamedThing vertebral element Skeletal element that forms around the notochord and is part of the vertebral column. RBO_relaxed.owl UBERON:0011138 biolink:NamedThing postcranial axial skeletal system Subdivision of the skeletal system which consists of the postcranial axial skeleton plus associated joints. RBO_relaxed.owl UBERON:0011241 biolink:NamedThing ethmoid region The most anterior region of the braincase. Provides structural support for peripheral olfactory organ. RBO_relaxed.owl UBERON:0011592 biolink:NamedThing future upper lip RBO_relaxed.owl UBERON:0011596 biolink:NamedThing future lower lip RBO_relaxed.owl UBERON:0012125 biolink:NamedThing dermatological-muscosal system Anatomical system that consists of the integumental system plus all mucosae and submucosae. RBO_relaxed.owl UBERON:0012172 biolink:NamedThing stomach primordium A primordium that has the potential to develop into a stomach. RBO_relaxed.owl UBERON:0012375 biolink:NamedThing subserosa A layer of tissue between the muscularis and serosa. RBO_relaxed.owl UBERON:0014704 biolink:NamedThing pleuroperitoneal canal lumen An anatomical space that is enclosed by a pleuroperitoneal canal. RBO_relaxed.owl UBERON:0014903 biolink:NamedThing primordial vasculature A portion of tissue that will develop into vasculature. RBO_relaxed.owl UBERON:0016548 biolink:NamedThing central nervous system gray matter layer A layer of of the central nervous system that is part of gray matter. RBO_relaxed.owl UBERON:0018260 biolink:NamedThing layer of muscle tissue Any organ component layer that consists of muscle tissue. RBO_relaxed.owl UBERON:0034878 biolink:NamedThing prechordal mesoderm The area of axial mesoderm that develops into the prechordal plate. RBO_relaxed.owl UBERON:0034929 biolink:NamedThing external soft tissue zone A region or zone on the surface of an organism that encompasses skin and any adnexa, down through muscles and bounded by underlying skeletal support structures. RBO_relaxed.owl UBERON:0035804 biolink:NamedThing future mouth The primordial mouth region of the developing head. RBO_relaxed.owl UBERON:8410050 biolink:NamedThing anorectum A subdivision of the digestive tract in humans that includes the rectum, the anal canal and the anus. RBO_relaxed.owl CL:0000192 biolink:NamedThing smooth muscle cell A non-striated, elongated, spindle-shaped cell found lining the digestive tract, uterus, and blood vessels. They develop from specialized myoblasts (smooth muscle myoblast). RBO_relaxed.owl CL:0000358 biolink:NamedThing sphincter associated smooth muscle cell A smooth muscle cell that is part of a sphincter. A sphincter is a typically circular muscle that normally maintains constriction of a natural body passage or orifice and which relaxes as required by normal physiological functioning. RBO_relaxed.owl CL:0000359 biolink:NamedThing vascular associated smooth muscle cell A smooth muscle cell associated with the vasculature. RBO_relaxed.owl CL:0002243 biolink:NamedThing smooth muscle cell of sphincter of pupil A circular smooth muscle cell of the iris, innervated by the ciliary nerves (parasympathetic), and acting to contract the pupil. This muscle cell derives from neuroectoderm. This smooth muscle cell results from transformation of epithelial cells to smooth muscle cells. RBO_relaxed.owl CL:0002504 biolink:NamedThing enteric smooth muscle cell A smooth muscle cell of the intestine. RBO_relaxed.owl CL:0002599 biolink:NamedThing smooth muscle cell of the esophagus A smooth muscle cell of the esophagus. RBO_relaxed.owl CL:0009052 biolink:NamedThing smooth muscle cell of anorectum A smooth muscle cell that is located in the anorectum. RBO_relaxed.owl CL:0019018 biolink:NamedThing blood vessel smooth muscle cell A smooth muscle cell that is part of any blood vessel. RBO_relaxed.owl CL:1000286 biolink:NamedThing smooth muscle cell of rectum A smooth muscle cell that is part of the rectum. RBO_relaxed.owl CL:1000443 biolink:NamedThing ciliary muscle cell A smooth muscle cell that is part of the ciliary body. RBO_relaxed.owl CL:0000055 biolink:NamedThing non-terminally differentiated cell A precursor cell with a limited number of potential fates. RBO_relaxed.owl CL:0000680 biolink:NamedThing muscle precursor cell A non-terminally differentiated cell that is capable of developing into a muscle cell. RBO_relaxed.owl CL:0007009 biolink:NamedThing prechondroblast Skeletogenic cell that has the potential to develop into a chondroblast; and arises from neural crest, meseosdermal and notochordal and connective tissue cells. RBO_relaxed.owl CL:0000035 biolink:NamedThing single fate stem cell A stem cell that self-renews as well as give rise to a single mature cell type. RBO_relaxed.owl CL:0000064 biolink:NamedThing ciliated cell A cell that has a filiform extrusion of the cell surface. RBO_relaxed.owl CL:0000066 biolink:NamedThing epithelial cell A cell that is usually found in a two-dimensional sheet with a free surface. The cell has a cytoskeleton that allows for tight cell to cell contact and for cell polarity where apical part is directed towards the lumen and the basal part to the basal lamina. RBO_relaxed.owl CL:0000080 biolink:NamedThing circulating cell A cell which moves among different tissues of the body, via blood, lymph, or other medium. RBO_relaxed.owl CL:0000151 biolink:NamedThing secretory cell A cell that specializes in controlled release of one or more substances. RBO_relaxed.owl CL:0000163 biolink:NamedThing endocrine cell A cell of an endocrine gland, ductless glands that secrete substances which are released directly into the circulation and which influence metabolism and other body functions. RBO_relaxed.owl CL:0000183 biolink:NamedThing contractile cell A cell whose primary function is to shorten. RBO_relaxed.owl CL:0000188 biolink:NamedThing cell of skeletal muscle A somatic cell located in skeletal muscle. RBO_relaxed.owl CL:0000211 biolink:NamedThing electrically active cell A cell whose function is determined by the generation or the reception of an electric signal. RBO_relaxed.owl CL:0000215 biolink:NamedThing barrier cell A cell whose primary function is to prevent the transport of stuff across compartments. RBO_relaxed.owl CL:0000219 biolink:NamedThing motile cell A cell that moves by its own activities. RBO_relaxed.owl CL:0000225 biolink:NamedThing anucleate cell A cell that lacks a nucleus. RBO_relaxed.owl CL:0000226 biolink:NamedThing single nucleate cell A cell with a single nucleus. RBO_relaxed.owl CL:0000227 biolink:NamedThing binucleate cell RBO_relaxed.owl CL:0000228 biolink:NamedThing multinucleate cell A cell with more than one nucleus. RBO_relaxed.owl CL:0000293 biolink:NamedThing structural cell A cell whose primary function is to provide structural support, to provide strength and physical integrity to the organism. RBO_relaxed.owl CL:0000325 biolink:NamedThing stuff accumulating cell A cell that is specialised to accumulate a particular substance(s). RBO_relaxed.owl CL:0000329 biolink:NamedThing oxygen accumulating cell RBO_relaxed.owl CL:0000349 biolink:NamedThing extraembryonic cell RBO_relaxed.owl CL:0000412 biolink:NamedThing polyploid cell A cell that contains more than two haploid sets of chromosomes. RBO_relaxed.owl CL:0000413 biolink:NamedThing haploid cell A cell whose nucleus contains a single haploid genome. RBO_relaxed.owl CL:0000630 biolink:NamedThing supporting cell A cell whose primary function is to support other cell types. RBO_relaxed.owl CL:0000988 biolink:NamedThing hematopoietic cell A cell of a hematopoietic lineage. RBO_relaxed.owl CL:0001035 biolink:NamedThing bone cell A connective tissue cell found in bone. RBO_relaxed.owl CL:0002242 biolink:NamedThing nucleate cell A cell containing at least one nucleus. RBO_relaxed.owl CL:0002319 biolink:NamedThing neural cell A cell that is part of the nervous system. RBO_relaxed.owl CL:0002320 biolink:NamedThing connective tissue cell A cell of the supporting or framework tissue of the body, arising chiefly from the embryonic mesoderm and including adipose tissue, cartilage, and bone. RBO_relaxed.owl CL:0002494 biolink:NamedThing cardiocyte A cell located in the heart, including both muscle and non muscle cells. RBO_relaxed.owl CL:0007001 biolink:NamedThing skeletogenic cell Cell that has the potential to form a skeletal cell type (e.g. cells in periosteum, cells in marrow) and produce extracellular matrix (often mineralized) and skeletal tissue (often mineralized). RBO_relaxed.owl CL:0009001 biolink:NamedThing compound eye retinal cell Any cell in the compound eye, a light sensing organ composed of ommatidia. RBO_relaxed.owl CL:0010007 biolink:NamedThing His-Purkinje system cell RBO_relaxed.owl CL:0010017 biolink:NamedThing zygote A zygote in a plant or an animal. RBO_relaxed.owl CL:0011115 biolink:NamedThing precursor cell A cell that, by division or terminal differentiation, can give rise to other cell types. RBO_relaxed.owl CL:2000020 biolink:NamedThing inner cell mass cell Any native cell that is part of a inner cell mass. RBO_relaxed.owl CL:2000022 biolink:NamedThing cardiac septum cell Any native cell that is part of a cardiac septum. RBO_relaxed.owl CL:4023072 biolink:NamedThing brain vascular cell A cell that is part of the brain vasculature. RBO_relaxed.owl CL:4033054 biolink:NamedThing perivascular cell A cell that is adjacent to a vessel. A perivascular cell plays a crucial role in maintaining vascular function and tissue homeostasis. This cell type regulates vessel integrity and flow dynamics. RBO_relaxed.owl CL:0000037 biolink:NamedThing hematopoietic stem cell A stem cell from which all cells of the lymphoid and myeloid lineages develop, including blood cells and cells of the immune system. Hematopoietic stem cells lack cell markers of effector cells (lin-negative). Lin-negative is defined by lacking one or more of the following cell surface markers: CD2, CD3 epsilon, CD4, CD5 ,CD8 alpha chain, CD11b, CD14, CD19, CD20, CD56, ly6G, ter119. RBO_relaxed.owl CL:0000052 biolink:NamedThing totipotent stem cell A stem cell from which all cells of the body can form. RBO_relaxed.owl CL:1000428 biolink:NamedThing stem cell of epidermis A somatic stem cell that is part of the epidermis. RBO_relaxed.owl CL:0000081 biolink:NamedThing blood cell A cell found predominately in the blood. RBO_relaxed.owl CL:0008001 biolink:NamedThing hematopoietic precursor cell Any hematopoietic cell that is a precursor of some other hematopoietic cell type. RBO_relaxed.owl CL:1001610 biolink:NamedThing bone marrow hematopoietic cell Hematopoietic cells resident in the bone marrow. Include: hematopoietic stem cells (lymphoid stem cells and myeloid stem cells) and the precursor cells for thrombocytes, erythrocytes, basophils, neutrophils, eosinophils, monocytes and lymphocytes. RBO_relaxed.owl CL:0000050 biolink:NamedThing megakaryocyte-erythroid progenitor cell A progenitor cell committed to the megakaryocyte and erythroid lineages. RBO_relaxed.owl CL:0000515 biolink:NamedThing skeletal muscle myoblast A myoblast that differentiates into skeletal muscle fibers. RBO_relaxed.owl CL:0000566 biolink:NamedThing angioblastic mesenchymal cell A mesenchymal stem cell capable of developing into blood vessel endothelium. RBO_relaxed.owl CL:0000765 biolink:NamedThing erythroblast A nucleated precursor of an erythrocyte that lacks hematopoietic lineage markers. RBO_relaxed.owl CL:0000839 biolink:NamedThing myeloid lineage restricted progenitor cell A progenitor cell restricted to the myeloid lineage. RBO_relaxed.owl CL:0002351 biolink:NamedThing progenitor cell of endocrine pancreas A progenitor cell that is able to differentiate into the pancreas alpha, beta and delta endocrine cells. This cell type expresses neurogenin-3 and Isl-1. RBO_relaxed.owl CL:0000038 biolink:NamedThing erythroid progenitor cell A progenitor cell committed to the erythroid lineage. RBO_relaxed.owl CL:0000764 biolink:NamedThing erythroid lineage cell A immature or mature cell in the lineage leading to and including erythrocytes. RBO_relaxed.owl CL:0000232 biolink:NamedThing erythrocyte A red blood cell. In mammals, mature erythrocytes are biconcave disks containing hemoglobin whose function is to transport oxygen. RBO_relaxed.owl CL:0000547 biolink:NamedThing proerythroblast An immature, nucleated erythrocyte occupying the stage of erythropoeisis that follows formation of erythroid progenitor cells. This cell is CD71-positive, has both a nucleus and a nucleolus, and lacks hematopoeitic lineage markers. RBO_relaxed.owl CL:0000558 biolink:NamedThing reticulocyte An immature erythrocyte that changes the protein composition of its plasma membrane by exosome formation and extrusion. The types of protein removed differ between species though removal of the transferrin receptor is apparent in mammals and birds. RBO_relaxed.owl CL:0000553 biolink:NamedThing megakaryocyte progenitor cell The earliest cytologically identifiable precursor in the thrombocytic series. This cell is capable of endomitosis and lacks expression of hematopoieitic lineage markers (lin-negative). RBO_relaxed.owl CL:0000049 biolink:NamedThing common myeloid progenitor A progenitor cell committed to myeloid lineage, including the megakaryocyte and erythroid lineages. RBO_relaxed.owl CL:0001060 biolink:NamedThing hematopoietic oligopotent progenitor cell, lineage-negative A hematopoietic oligopotent progenitor cell that has the ability to differentiate into limited cell types but lacks lineage cell markers and self renewal capabilities. Cell lacks hematopoeitic lineage markers. RBO_relaxed.owl CL:0000556 biolink:NamedThing megakaryocyte A large hematopoietic cell (50 to 100 micron) with a lobated nucleus. Once mature, this cell undergoes multiple rounds of endomitosis and cytoplasmic restructuring to allow platelet formation and release. RBO_relaxed.owl CL:0000766 biolink:NamedThing myeloid leukocyte A cell of the monocyte, granulocyte, or mast cell lineage. RBO_relaxed.owl CL:0000056 biolink:NamedThing myoblast A cell that is commited to differentiating into a muscle cell. Embryonic myoblasts develop from the mesoderm. They undergo proliferation, migrate to their various sites, and then differentiate into the appropriate form of myocytes. Myoblasts also occur as transient populations of cells in muscles undergoing repair. RBO_relaxed.owl CL:0000134 biolink:NamedThing mesenchymal stem cell A connective tissue cell that normally gives rise to other cells that are organized as three-dimensional masses. In humans, this cell type is CD73-positive, CD90-positive, CD105-positive, CD45-negative, CD34-negative, and MHCII-negative. They may further differentiate into osteoblasts, adipocytes, myocytes, neurons, or chondroblasts in vitro. Originally described as residing in the bone marrow, this cell type is now known to reside in many, if not all, adult organs. RBO_relaxed.owl CL:0002503 biolink:NamedThing adventitial cell A cell of the adventitial layer of ductal structures such as the uterer, defent duct, biliary duct, etc RBO_relaxed.owl CL:2000072 biolink:NamedThing adipose microvascular endothelial cell Any microvascular endothelial cell that is part of a adipose tissue. RBO_relaxed.owl CL:4033018 biolink:NamedThing lung megakaryocyte A megakaryocyte that is resident in the lung connective tissue. RBO_relaxed.owl CL:0000549 biolink:NamedThing basophilic erythroblast A nucleated immature erythrocyte, having cytoplasm generally similar to that of the earlier proerythroblast but sometimes even more basophilic, and usually regular in outline. The nucleus is still relatively large, but the chromatin strands are thicker and more deeply staining, giving a coarser appearance; the nucleoli have disappeared. This cell is CD71-positive and lacks hematopoeitic lineage markers. RBO_relaxed.owl CL:0000550 biolink:NamedThing polychromatophilic erythroblast A nucleated, immature erythrocyte in which the nucleus occupies a relatively smaller part of the cell than in its precursor, the basophilic erythroblast. The cytoplasm is beginning to acquire hemoglobin and thus is no longer a purely basophilic, but takes on acidophilic aspects, which becomes progressively more marked as the cell matures. The chromatin of the nucleus is arranged in coarse, deeply staining clumps. This cell is CD71-positive and lacks hematopoeitic lineage markers. RBO_relaxed.owl CL:0001066 biolink:NamedThing erythroid progenitor cell, mammalian A progenitor cell committed to the erythroid lineage. This cell is ter119-positive but lacks expression of other hematopoietic lineage markers (lin-negative). RBO_relaxed.owl GO:0005840 biolink:NamedThing ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. RBO_relaxed.owl GO:0005929 biolink:NamedThing cilium A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body. RBO_relaxed.owl GO:0098644 biolink:NamedThing complex of collagen trimers A complex of collagen trimers such as a fibril or collagen network. RBO_relaxed.owl UBERON:0000014 biolink:NamedThing zone of skin Any portion of the organ that covers that body and consists of a layer of epidermis and a layer of dermis. RBO_relaxed.owl UBERON:0000042 biolink:NamedThing serous membrane Multi-tissue structure that is comprised of a secretory epithelial layer (mesothelium) and a connective tissue layer. RBO_relaxed.owl UBERON:0000058 biolink:NamedThing duct A tubular structure that transports secreted or excreted substances. RBO_relaxed.owl UBERON:0000086 biolink:NamedThing zona pellucida A glycoprotein membrane surrounding the plasma membrane of an oocyte. It is a vital constitutive part of the latter, external but not extraneous to it. The zona pellucida first appears in multilaminar primary oocytes. RBO_relaxed.owl UBERON:0000094 biolink:NamedThing membrane organ Nonparenchymatous organ that primarily consists of dense connective tissue organized into a sheet which interconnects two or more organs, separates two or more body spaces from one another, or surrounds an organ or body part. Examples: interosseous membrane of forearm, obturator membrane, tympanic membrane, fibrous pericardium, fascia lata, dura mater. [FMA]. RBO_relaxed.owl UBERON:0000117 biolink:NamedThing respiratory tube A tube in the respiratory system. Examples: bronchus, bronchiole, trachea. RBO_relaxed.owl UBERON:0000344 biolink:NamedThing mucosa A lining of mostly endodermal origin, covered in epithelium, which is involved in absorption and secretion. They line various body cavities that are exposed to the external environment and internal organs. It is at several places continuous with skin: at the nostrils, the lips, the ears, the genital area, and the anus. The sticky, thick fluid secreted by the mucous membranes and gland is termed mucus. The term mucous membrane refers to where they are found in the body and not every mucous membrane secretes mucus[WP]. RBO_relaxed.owl UBERON:0000483 biolink:NamedThing epithelium Portion of tissue, that consists of one or more layers of epithelial cells connected to each other by cell junctions and which is underlain by a basal lamina. Examples: simple squamous epithelium, glandular cuboidal epithelium, transitional epithelium, myoepithelium[CARO]. RBO_relaxed.owl UBERON:0001173 biolink:NamedThing biliary tree A complex network of conduits that begins with the canals of Hering (intralobar bile duct) and progressively merges into a system of interlobular, septal, and major ducts which then coalesce to form the extrahepatic bile ducts, which finally deliver bile to the intestine, and in some species to the gallbladder. RBO_relaxed.owl UBERON:0001279 biolink:NamedThing portal triad A multi-organ-part structure that consists of three vessels of the portal lobule including the bile duct, a terminal branch of the hepatic artery and portal vein, and may also include a lymphatic vessel. RBO_relaxed.owl UBERON:0001804 biolink:NamedThing capsule of lens The elastic, clear, membrane-like structure, that is outer most layer of the lens. RBO_relaxed.owl UBERON:0001969 biolink:NamedThing blood plasma The liquid component of blood, in which erythrocytes are suspended. RBO_relaxed.owl UBERON:0001981 biolink:NamedThing blood vessel A vessel through which blood circulates in the body. RBO_relaxed.owl UBERON:0002067 biolink:NamedThing dermis The dermis is a layer of skin between the epidermis (with which it makes up the skin) and subcutaneous tissues, and is composed of two layers, the papillary and reticular dermis[WP]. RBO_relaxed.owl UBERON:0002072 biolink:NamedThing hypodermis Lowermost layer of the integumentary system in vertebrates. Types of cells that are found in the hypodermis are fibroblasts, adipose cells, and macrophages. It is derived from the mesoderm, but unlike the dermis, it is not derived from the dermatome region of the mesoderm. The hypodermis is used mainly for fat storage[WP]. RBO_relaxed.owl UBERON:0002097 biolink:NamedThing skin of body The organ covering the body that consists of the dermis and epidermis. RBO_relaxed.owl UBERON:0002330 biolink:NamedThing exocrine system Anatomical system that consists of the glands and parts of glands that produce exocrine secretions and help to integrate and control bodily metabolic activity. Exocrine glands are glands that secrete their products (hormones) into ducts (duct glands). They are the counterparts to endocrine glands, which secrete their products (hormones) directly into the bloodstream (ductless glands) or release hormones (paracrines) that affect only target cells nearby the release site. [Wikipedia]. RBO_relaxed.owl UBERON:0002365 biolink:NamedThing exocrine gland A gland that secretes products (excluding hormones and other chemical messengers) into ducts (duct glands) which lead directly into the external environment[WP]. Typical exocrine glands include sweat glands, salivary glands, mammary glands, stomach, liver, pancreas. RBO_relaxed.owl UBERON:0005734 biolink:NamedThing tunica adventitia of blood vessel The outermost layer of a blood vessel, composed mainly of fibrous tissue. RBO_relaxed.owl UBERON:0005769 biolink:NamedThing basement membrane of epithelium An acellular membrane that is part of the epithelium, lies adjacent to the epithelial cells, and is the fusion of the the basal lamina and the reticular lamina. RBO_relaxed.owl UBERON:0007195 biolink:NamedThing stroma of bone marrow The stroma of the bone marrow is all tissue not directly involved in the primary function of hematopoiesis. The yellow bone marrow belongs here, and makes the majority of the bone marrow stroma, in addition to stromal cells located in the red bone marrow. Yellow bone marrow is found in the Medullary cavity. Still, the stroma is indirectly involved in hematopoiesis, since it provides the hematopoietic microenvironment that facilitates hematopoiesis by the parenchymal cells. For instance, they generate colony stimulating factors, affecting hematopoiesis. RBO_relaxed.owl UBERON:0007324 biolink:NamedThing pancreatic lobule A dense accumulation of exocrine glands in the pancreas often surrounding islets of Langerhans. RBO_relaxed.owl UBERON:0011234 biolink:NamedThing fibrous membrane of synovial tendon sheath RBO_relaxed.owl UBERON:0011823 biolink:NamedThing dense connective tissue Dense connective tissue is mainly composed of collagen type I. Crowded between the collagen fibers are rows of fibroblasts, fiber-forming cells, that manufacture the fibers. Dense connective tissue forms strong, rope-like structures such as tendons and ligaments. Tendons attach skeletal muscles to bones; ligaments connect bones to bones at joints. Ligaments are more stretchy and contain more elastic fibers than tendons. Dense connective tissue also make up the lower layers of the skin (dermis), where it is arranged in sheets. RBO_relaxed.owl UBERON:0011860 biolink:NamedThing collection of collagen fibrils RBO_relaxed.owl UBERON:0011953 biolink:NamedThing stomach glandular region A region of the stomach that is lined with glandular epithelium. RBO_relaxed.owl UBERON:0012430 biolink:NamedThing tunica fibrosa of eyeball The sclera and cornea form the fibrous tunic of the bulb of the eye; the sclera is opaque, and constitutes the posterior five-sixths of the tunic; the cornea is transparent, and forms the anterior sixth. RBO_relaxed.owl CL:0000067 biolink:NamedThing ciliated epithelial cell An epithelial cell that has a cilia. RBO_relaxed.owl CL:1000271 biolink:NamedThing lung ciliated cell RBO_relaxed.owl CL:4030034 biolink:NamedThing respiratory ciliated cell A ciliated cell of the respiratory system. Ciliated cells are present in airway epithelium. RBO_relaxed.owl CL:0000068 biolink:NamedThing duct epithelial cell An epithelial cell that is part of a duct. RBO_relaxed.owl CL:0000075 biolink:NamedThing columnar/cuboidal epithelial cell A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube. RBO_relaxed.owl CL:0000076 biolink:NamedThing squamous epithelial cell RBO_relaxed.owl CL:0000082 biolink:NamedThing epithelial cell of lung An epithelial cell of the lung. RBO_relaxed.owl CL:0000083 biolink:NamedThing epithelial cell of pancreas An epithelial cell of the pancreas. RBO_relaxed.owl CL:0000150 biolink:NamedThing glandular epithelial cell A specialized epithelial cell that is capable of synthesizing and secreting certain biomolecules. RBO_relaxed.owl CL:0000182 biolink:NamedThing hepatocyte The main structural component of the liver. They are specialized epithelial cells that are organized into interconnected plates called lobules. Majority of cell population of liver, polygonal in shape, arranged in plates or trabeculae between sinusoids; may have single nucleus or binucleated. RBO_relaxed.owl CL:0000362 biolink:NamedThing epidermal cell An epithelial cell of the integument (the outer layer of an organism). RBO_relaxed.owl CL:0002076 biolink:NamedThing endo-epithelial cell An epithelial cell derived from endoderm. RBO_relaxed.owl CL:0002077 biolink:NamedThing ecto-epithelial cell An epithelial cell derived from ectoderm. RBO_relaxed.owl CL:0002078 biolink:NamedThing meso-epithelial cell Epithelial cell derived from mesoderm or mesenchyme. RBO_relaxed.owl CL:0002178 biolink:NamedThing epithelial cell of stomach An epithelial cell found in the lining of the stomach. RBO_relaxed.owl CL:0002222 biolink:NamedThing vertebrate lens cell A cell comprising the transparent, biconvex body separating the posterior chamber and vitreous body, and constituting part of the refracting mechanism of the mammalian eye. RBO_relaxed.owl CL:0002251 biolink:NamedThing epithelial cell of alimentary canal An epithelial cell of the musculomembranous digestive tube extending from the mouth to the anus. RBO_relaxed.owl CL:0002252 biolink:NamedThing epithelial cell of esophagus An epithelial cell of the esophagus. RBO_relaxed.owl CL:0002308 biolink:NamedThing epithelial cell of skin gland An epithelial cell of a skin gland. RBO_relaxed.owl CL:0002563 biolink:NamedThing intestinal epithelial cell An epithelial cell of the intestine. RBO_relaxed.owl CL:0011108 biolink:NamedThing colon epithelial cell Epithelial cell that is part of the colon epithelium. RBO_relaxed.owl CL:1000415 biolink:NamedThing epithelial cell of gallbladder An epithelial cell that is part of the gallbladder. RBO_relaxed.owl CL:1001433 biolink:NamedThing epithelial cell of exocrine pancreas An epithelial cell of the exocrine pancreas. RBO_relaxed.owl CL:2000064 biolink:NamedThing ovarian surface epithelial cell Any epithelial cell that is part of a female gonad. RBO_relaxed.owl CL:0000069 biolink:NamedThing branched duct epithelial cell RBO_relaxed.owl CL:0000071 biolink:NamedThing blood vessel endothelial cell An endothelial cell that lines the vasculature. RBO_relaxed.owl CL:0000077 biolink:NamedThing mesothelial cell A flattened epithelial cell of mesenchymal origin that lines the serous cavity. RBO_relaxed.owl CL:1001576 biolink:NamedThing oral mucosa squamous cell Squamous cell of oral epithelium. RBO_relaxed.owl CL:0002139 biolink:NamedThing endothelial cell of vascular tree An endothelial cell of the vascular tree, which includes blood vessels and lymphatic vessels. RBO_relaxed.owl CL:1000414 biolink:NamedThing endothelial cell of venule An endothelial cell that is part of the venule. RBO_relaxed.owl CL:1001567 biolink:NamedThing lung endothelial cell RBO_relaxed.owl CL:1001568 biolink:NamedThing pulmonary artery endothelial cell RBO_relaxed.owl CL:0000213 biolink:NamedThing lining cell A cell within an epithelial cell sheet whose main function is to act as an internal or external covering for a tissue or an organism. RBO_relaxed.owl CL:0000115 biolink:NamedThing endothelial cell An endothelial cell comprises the outermost layer or lining of anatomical structures and can be squamous or cuboidal. In mammals, endothelial cell has vimentin filaments and is derived from the mesoderm. RBO_relaxed.owl CL:0000214 biolink:NamedThing synovial cell A cell located in the synovial joint. RBO_relaxed.owl CL:0002195 biolink:NamedThing hepatic stem cell A stem cell that can give rise to the cells of the liver. The term usually refers to the self-renewing pool of hepatocyte precursors in the adult liver (differently from 'hepatoblast', often used for fetal precursors of hepatocytes). RBO_relaxed.owl CL:1000272 biolink:NamedThing lung secretory cell RBO_relaxed.owl CL:1000488 biolink:NamedThing cholangiocyte An epithelial cell that is part of the bile duct. Cholangiocytes contribute to bile secretion via net release of bicarbonate and water. They are cuboidal epithelium in the small interlobular bile ducts, but become columnar and mucus secreting in larger bile ducts approaching the porta hepatis and the extrahepatic ducts. RBO_relaxed.owl UBERON:0000006 biolink:NamedThing islet of Langerhans The clusters of hormone-producing cells that are scattered throughout the pancreas. RBO_relaxed.owl UBERON:0000016 biolink:NamedThing endocrine pancreas The part of the pancreas that is part of the endocrine system and is made up of islet cells, which produce insulin, glucagon and somatostatin. RBO_relaxed.owl UBERON:0000017 biolink:NamedThing exocrine pancreas The part of the pancreas that is part of the exocrine system and which produces and store zymogens of digestive enzymes, such as chymotrypsinogen and trypsinogen in the acinar cells [GO]. RBO_relaxed.owl UBERON:0000065 biolink:NamedThing respiratory tract Anatomical structure that is part of the respiratory system. In mammals consists of upper and lower tracts. RBO_relaxed.owl UBERON:0000072 biolink:NamedThing proximo-distal subdivision of respiratory tract An section of a respiratory tract. RBO_relaxed.owl UBERON:0000101 biolink:NamedThing lobe of lung A lung lobe is one of the rounded projections that compose the lung[GO]. RBO_relaxed.owl UBERON:0001113 biolink:NamedThing lobe of liver Traditional gross anatomy divided the liver into four lobes based on surface features. The falciform ligament is visible on the front (anterior side) of the liver. This divides the liver into a left anatomical lobe, and a right anatomical lobe. RBO_relaxed.owl UBERON:0001171 biolink:NamedThing portal lobule The triangular region on the periphery of the liver lobules that contain a bile duct and a terminal branch of the hepatic artery and portal vein, and may also include a lymphatic vessel. RBO_relaxed.owl UBERON:0001172 biolink:NamedThing hepatic acinus The functional unit of the liver, consisting of a mass of hepatocytes from adjacent liver lobules aligned around the hepatic arterioles and portal venules just as they anastomose into sinusoids. RBO_relaxed.owl UBERON:0001263 biolink:NamedThing pancreatic acinus The secretory units of the exocrine pancreas, where fluid containing digestive enzymes is produced; consists of a group of secretory cells surrounding a luminal space that connects to the pancreatic duct. RBO_relaxed.owl UBERON:0001280 biolink:NamedThing liver parenchyma The functional units of the liver including the lobules. RBO_relaxed.owl UBERON:0002048 biolink:NamedThing lung Respiration organ that develops as an outpocketing of the esophagus. RBO_relaxed.owl UBERON:0002107 biolink:NamedThing liver An exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes[GO]. RBO_relaxed.owl UBERON:0002110 biolink:NamedThing gallbladder An organ that aids digestion and stores bile produced by the liver[WP]. RBO_relaxed.owl UBERON:0002394 biolink:NamedThing bile duct Any of the ducts that form the biliary tree, carrying bile from the liver to the small intestine. RBO_relaxed.owl UBERON:0003580 biolink:NamedThing lower respiratory tract connective tissue A portion of connective tissue that is part of a lower respiratory tract [Automatically generated definition]. RBO_relaxed.owl UBERON:0003603 biolink:NamedThing lower respiratory tract cartilage A cartilage that is part of a lower respiratory tract [Automatically generated definition]. RBO_relaxed.owl UBERON:0004058 biolink:NamedThing biliary ductule One of the fine terminal elements of the bile duct system, leaving the portal canal, and pursuing a course at the periphery of a lobule of the liver[BTO]. the excretory ducts of the liver that connect the interlobular ductules to the right or left hepatic duct[MP]. RBO_relaxed.owl UBERON:0004185 biolink:NamedThing endodermal part of digestive tract A portions of the gut that is derived from endoderm. RBO_relaxed.owl UBERON:0004647 biolink:NamedThing liver lobule The polygonal structure of the liver that consists of hepatocytes radiating outward from a hepatic vein. RBO_relaxed.owl UBERON:0004781 biolink:NamedThing gallbladder lamina propria A lamina propria that is part of a gallbladder [Automatically generated definition]. RBO_relaxed.owl UBERON:0004915 biolink:NamedThing sphincter of hepatopancreatic ampulla Muscular valve that controls the flow of digestive juices (bile and pancreatic juice) through the ampulla of Vater into the second part of the duodenum. Relaxed by the hormone Cholecystokinin (CCK) via vasoactive intestinal polypeptide (VIP).[WP]. RBO_relaxed.owl UBERON:0004938 biolink:NamedThing submucosa of biliary tree A submucosa that is part of a biliary tree [Automatically generated definition]. RBO_relaxed.owl UBERON:0004999 biolink:NamedThing mucosa of biliary tree A mucosa that is part of a biliary tree [Automatically generated definition]. RBO_relaxed.owl UBERON:0005033 biolink:NamedThing mucosa of gallbladder A mucosa that is part of a gallbladder [Automatically generated definition]. RBO_relaxed.owl UBERON:0005911 biolink:NamedThing endo-epithelium Epithelium that derives from the endoderm. Examples: urothelium, transitional epithelium of ureter, epithelium of prostatic gland.[FMA]. RBO_relaxed.owl UBERON:0007329 biolink:NamedThing pancreatic duct A duct that collects and carries secretions of the exocrine pancreas to the intestine. RBO_relaxed.owl UBERON:0008946 biolink:NamedThing lung parenchyma A parenchyma that is part of a lung. RBO_relaxed.owl UBERON:0009708 biolink:NamedThing dorsal pancreas RBO_relaxed.owl UBERON:0009709 biolink:NamedThing ventral pancreas RBO_relaxed.owl UBERON:0009778 biolink:NamedThing pleural sac A serous sac that has the pleura and the pleural cavity as parts. RBO_relaxed.owl UBERON:0010183 biolink:NamedThing liver trabecula A trabecula that is part of a liver. RBO_relaxed.owl UBERON:0010368 biolink:NamedThing pulmonary lobule The smallest anatomical unit of the lung, measuring 0.50 to 2.00 cm in diameter. Each lobule is composed of 4-8 terminal bronchioles and their distal alveolar ducts and sacs. The lobules are separated by fibrous interlobular septa. RBO_relaxed.owl UBERON:0011862 biolink:NamedThing pulmonary collagen fibril The connective tissue bundles in the extracellular matrix of pulmonary tissue that are composed of collagen, and play a role in tissue strength and elasticity. RBO_relaxed.owl UBERON:0016478 biolink:NamedThing liver stroma A stroma that is part of a liver. RBO_relaxed.owl UBERON:0019190 biolink:NamedThing mucous gland of lung RBO_relaxed.owl UBERON:0022361 biolink:NamedThing lung field A specific region of the foregut into the area in which the lung will develop. RBO_relaxed.owl UBERON:0036343 biolink:NamedThing wall of gallbladder RBO_relaxed.owl UBERON:8400023 biolink:NamedThing liver subserosa Subserosal tissue of liver. A zone of areolar connective tissue lying beneath the serous coat of the liver and distinguished with difficulty from the fibrous capsule of Glisson. RBO_relaxed.owl UBERON:8410077 biolink:NamedThing airway submucosal gland A submucosal gland found in a respiratory tract. RBO_relaxed.owl UBERON:8600017 biolink:NamedThing bronchopulmonary segment A discrete anatomical unit of the lung that is composed of a segmental bronchus and the lung tissue supplied by that bronchus. A bronchopulmonary segment exhibits a pyramidal shape, with its apex pointing towards the center of the lung and its base toward the pleural surface. RBO_relaxed.owl CL:0000095 biolink:NamedThing neuron associated cell RBO_relaxed.owl CL:0002590 biolink:NamedThing smooth muscle cell of the brain vasculature A vascular associated smooth muscle cell of the brain vasculature. RBO_relaxed.owl CL:0009004 biolink:NamedThing retinal cell Any cell in the retina, the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates. RBO_relaxed.owl CL:2000044 biolink:NamedThing brain microvascular endothelial cell Any microvascular endothelial cell that is part of a brain. RBO_relaxed.owl CL:0002585 biolink:NamedThing retinal blood vessel endothelial cell A blood vessel endothelial cell that is part of the retina. RBO_relaxed.owl CL:0002672 biolink:NamedThing retinal progenitor cell A multi-fate stem cell that can give rise to different retinal cell types including rod and cone cells. RBO_relaxed.owl CL:0007004 biolink:NamedThing premigratory neural crest cell Cell that is part of the neural crest region of the neuroepithelium, prior to migration. Note that not all premigratory neural crest cells may become migratory neural crest cells. RBO_relaxed.owl CL:0010009 biolink:NamedThing camera-type eye photoreceptor cell RBO_relaxed.owl CL:1000444 biolink:NamedThing mesothelial cell of anterior chamber of eye A mesothelial cell that is part of the anterior chamber of eyeball. RBO_relaxed.owl CL:2000010 biolink:NamedThing dermis blood vessel endothelial cell Any blood vessel endothelial cell that is part of a dermis. RBO_relaxed.owl GO:0097386 biolink:NamedThing glial cell projection A prolongation or process extending from a glial cell. RBO_relaxed.owl UBERON:0000019 biolink:NamedThing camera-type eye An organ of sight that includes the camera-type eyeball and supporting structures such as the lacrimal apparatus, the conjunctiva, the eyelid. RBO_relaxed.owl UBERON:0000095 biolink:NamedThing cardiac neural crest Portion of neural crest that develops from the dorsal neural tube. It overlaps the vagal neural crest and migrates to populate the pharyngeal arches 3, 4 and 6 (producing structures in the head) and to the heart, forming connective tissue that separates the great vessels of the heart. [Wikipedia]. RBO_relaxed.owl UBERON:0000159 biolink:NamedThing anal canal The terminal part of the large intestine, continuous proximally with the rectum and distally terminates with the anus. RBO_relaxed.owl UBERON:0000389 biolink:NamedThing lens cortex Tissue that surrounds the lens nucleus. RBO_relaxed.owl UBERON:0000390 biolink:NamedThing lens nucleus The core of the crystalline lens, surrounded by the cortex. RBO_relaxed.owl UBERON:0000955 biolink:NamedThing brain The brain is the center of the nervous system in all vertebrate, and most invertebrate, animals. Some primitive animals such as jellyfish and starfish have a decentralized nervous system without a brain, while sponges lack any nervous system at all. In vertebrates, the brain is located in the head, protected by the skull and close to the primary sensory apparatus of vision, hearing, balance, taste, and smell[WP]. RBO_relaxed.owl UBERON:0000965 biolink:NamedThing lens of camera-type eye A transparent and refractive lens located posterior to the iris. The lens of camera-type eye refracts light to be focused on the retina. RBO_relaxed.owl UBERON:0000966 biolink:NamedThing retina The retina is the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates. RBO_relaxed.owl UBERON:0001017 biolink:NamedThing central nervous system The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the neural tube derivatives: the brain and spinal cord. In invertebrates it includes central ganglia plus nerve cord. RBO_relaxed.owl UBERON:0001245 biolink:NamedThing anus Orifice at the opposite end of an animal's digestive tract from the mouth. Its function is to expel feces, unwanted semi-solid matter produced during digestion, which, depending on the type of animal, may be one or more of: matter which the animal cannot digest, such as bones; food material after all the nutrients have been extracted, for example cellulose or lignin; ingested matter which would be toxic if it remained in the digestive tract; and dead or excess gut bacteria and other endosymbionts. RBO_relaxed.owl UBERON:0001768 biolink:NamedThing uvea The pigmented middle of the three concentric layers that make up an eye, consisting of the iris, ciliary body and choroid[WP,edited]. RBO_relaxed.owl UBERON:0001769 biolink:NamedThing iris The adjustable membrane, composed of the stroma and pigmented epithelium, located just in front of the crystalline lens within the eye. RBO_relaxed.owl UBERON:0001775 biolink:NamedThing ciliary body The thickened portion of the vascular tunic, which lies between the choroid and the iris, composed of ciliary muscle and ciliary processes. RBO_relaxed.owl UBERON:0001779 biolink:NamedThing iris stroma The delicate vascular connective tissue that lies between the anterior surface of the iris and the pars iridica retinae. RBO_relaxed.owl UBERON:0001781 biolink:NamedThing layer of retina Any of the layers that make up the retina[MP]. RBO_relaxed.owl UBERON:0001801 biolink:NamedThing anterior segment of eyeball Any of the parts of the eye that lie in front of, or ventral to, the lens (inclusive). RBO_relaxed.owl UBERON:0001802 biolink:NamedThing posterior segment of eyeball Any of the parts of the eye that lie in back of, or dorsal to, the lens (but not inclusive). RBO_relaxed.owl UBERON:0001896 biolink:NamedThing medulla oblongata Organ component of neuraxis that has as its parts the medullary reticular formation, inferior olivary complex and cochlear nuclear complex, among other structures[FMA]. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate[GO]. RBO_relaxed.owl UBERON:0001948 biolink:NamedThing regional part of spinal cord A multi-tissue structure that is part of a spinal cord. RBO_relaxed.owl UBERON:0002240 biolink:NamedThing spinal cord Part of the central nervous system located in the vertebral canal continuous with and caudal to the brain; demarcated from brain by plane of foramen magnum. It is composed of an inner core of gray matter in which nerve cells predominate, and an outer layer of white matter in which myelinated nerve fibers predominate, and surrounds the central canal. (CUMBO). RBO_relaxed.owl UBERON:0002328 biolink:NamedThing notochord A flexible rod-shaped body found in embryos of all chordates. It is composed of cells derived from the mesoderm and defines the primitive axis of the embryo. In some chordates, it persists throughout life as the main axial support of the body, while in most vertebrates it becomes the nucleus pulposus of the intervertebral disc. The notochord is found ventral to the neural tube. RBO_relaxed.owl UBERON:0002342 biolink:NamedThing neural crest A specialized region of ectoderm found between the neural ectoderm (neural plate) and non-neural ectoderm and composed of highly migratory pluripotent cells that delaminate in early embryonic development from the dorsal neural tube and give rise to an astounding variety of differentiated cell types[MP]. RBO_relaxed.owl UBERON:0002346 biolink:NamedThing neurectoderm Embryonic ectoderm that gives rise to nervous tissue. RBO_relaxed.owl UBERON:0002419 biolink:NamedThing skin gland A gland that is part of a skin of body [Automatically generated definition]. RBO_relaxed.owl UBERON:0002616 biolink:NamedThing regional part of brain Anatomical divisons of the brain according to one or more criteria, e.g. cytoarchitectural, gross anatomy. Parts may be contiguous in 3D or not, e.g., basal ganglia. RBO_relaxed.owl UBERON:0003023 biolink:NamedThing pontine tegmentum Dorsal portion of the pons, containing cranial nervee nuclei, ascending and descending tracts and reticular nuclei. It is continuous with the reticular formation of the medulla (Carpenter, A Core Text of Neuroanatomy, 3rd ed, 1985, pg 133). RBO_relaxed.owl UBERON:0003052 biolink:NamedThing midbrain-hindbrain boundary The part of the brain that is the morphological boundary between the midbrain and hindbrain and that is the location of an organizing center which patterns the midbrain and hindbrain primordia of the neural plate. RBO_relaxed.owl UBERON:0003056 biolink:NamedThing pre-chordal neural plate The portion of neural plate anterior to the mid-hindbrain junction. RBO_relaxed.owl UBERON:0003072 biolink:NamedThing optic cup Multi-tissue structure that is comprised of neural and non-neural epithelial layers which will form the retina and retinal pigmented epithelium of the mature eye[ZFA]. double walled structured formed by expansion and invagination of the distal end of the optic vesicle that develops into the pigmented and sensory layers of the retina while the mouth of the optic cup eventually forms the pupil of the eye[MP]. RBO_relaxed.owl UBERON:0003083 biolink:NamedThing trunk neural crest Trunk portion of the neural crest. The trunk neural crest lies between the vagal and sacral neural crest and gives rise to two groups of cells. One group migrates dorsolateral and populates the skin, forming pigment cells and the other migrates ventrolateral through the anterior sclerotome to become the epinephrine-producing cells of the adrenal gland and the neurons of the sympathetic nervous system. Some cells remain in the sclerotome to form the dorsal root ganglia [Wikipedia]. RBO_relaxed.owl UBERON:0003099 biolink:NamedThing cranial neural crest Neural crest cells (NCCs) originating in the anterior part of the developing embryo and residing between the mid-diencephalon and the forming hindbrain; cranial NCCs migrate dorsolaterally to form the craniofacial mesenchyme that differentiates into various craniofacial cartilages and bones, cranial neurons, glia, and connective tissues of the face; these cells enter the pharyngeal pouches and arches where they give rise to thymic cells, bones of the middle ear and jaw (mandible), and the odontoblasts of the tooth primordia; like their counterparts in the trunk, cranial NCCs also contribute to the developing peripheral nervous system, along with the pigmented cell (i.e. melanocyte) lineage. RBO_relaxed.owl UBERON:0003269 biolink:NamedThing skeletal muscle tissue of eye A portion of skeletal muscle tissue that is part of a eye [Automatically generated definition]. RBO_relaxed.owl UBERON:0003329 biolink:NamedThing submucosa of anal canal A submucosa that is part of an anal canal [Automatically generated definition]. RBO_relaxed.owl UBERON:0003339 biolink:NamedThing ganglion of central nervous system A ganglion that is part of a central nervous system [Automatically generated definition]. RBO_relaxed.owl UBERON:0003342 biolink:NamedThing mucosa of anal canal A mucosa that is part of an anal canal [Automatically generated definition]. RBO_relaxed.owl UBERON:0003386 biolink:NamedThing smooth muscle of eye Any of the striated muscles that move the eye and include: superior rectus, inferior rectus, medial rectus, lateral rectus, superior oblique, inferior oblique, retractor bulbi. RBO_relaxed.owl UBERON:0003499 biolink:NamedThing brain blood vessel A blood vessel that is part of a brain [Automatically generated definition]. RBO_relaxed.owl UBERON:0003967 biolink:NamedThing cutaneous elastic tissue The slender connective tissue fiber in the extracellular matrix of skin tissue that is composed of microfibrils and amorphous elastin and is characterized by great elasticity. RBO_relaxed.owl UBERON:0004062 biolink:NamedThing neural tube marginal layer The outermost layer of the neural tube that consists of axons from the developing mantle layer and will form the white matter. RBO_relaxed.owl UBERON:0004064 biolink:NamedThing neural tube basal plate The region of the mantle layer of the neural tube that lies ventral to the sulcus limitans and contains primarily motor neurons and interneurons. RBO_relaxed.owl UBERON:0004128 biolink:NamedThing optic vesicle The optic vesicle is the evagination of neurectoderm that precedes formation of the optic cup[GO]. Portion of tissue that is comprised of neuroepitheium which has pinched off from the anterior neural keel and will form the optic cup[ZFA]. RBO_relaxed.owl UBERON:0004277 biolink:NamedThing eye muscle A muscle that is part of the eye region. RBO_relaxed.owl UBERON:0004731 biolink:NamedThing neuromere A transverse unitary subdivision of the neural tube that shares a common dorsoventral structure (floor, basal, alar, and roof plates), but each having differential molecular identities and fates; they comprise the secondary prosencephalon, diencephalon (prosomeres), the midbrain (mesomeres), and the hindbrain (rhombomeres). RBO_relaxed.owl UBERON:0004733 biolink:NamedThing segmental subdivision of hindbrain An organ subunit that is part of a hindbrain [Automatically generated definition]. RBO_relaxed.owl UBERON:0004756 biolink:NamedThing dermal skeletal element Dermis-derived entity that is made of skeletal tissue. RBO_relaxed.owl UBERON:0004760 biolink:NamedThing gland of anal canal A gland that is part of an anal canal [Automatically generated definition]. RBO_relaxed.owl UBERON:0004906 biolink:NamedThing ectodermal part of digestive tract A portion of the gut that is derived from ectoderm. RBO_relaxed.owl UBERON:0005076 biolink:NamedThing hindbrain-spinal cord boundary An anatomical boundary that adjacent_to a hindbrain and adjacent_to a spinal cord. RBO_relaxed.owl UBERON:0005158 biolink:NamedThing parenchyma of central nervous system The functional tissue of the central nervous system consisting of neurons and glial cells. RBO_relaxed.owl UBERON:0005426 biolink:NamedThing lens vesicle Portion of tissue that gives rise to the lens. RBO_relaxed.owl UBERON:0005428 biolink:NamedThing vagal neural crest Vagal neural crest is adjacent to the first seven somites gives rise to both ganglionic and ectomesenchymal derivatives[ZFA]. RBO_relaxed.owl UBERON:0005496 biolink:NamedThing neural tube lateral wall Portion of tissue on the side of the lumen of the neural tube. RBO_relaxed.owl UBERON:0005497 biolink:NamedThing non-neural ectoderm RBO_relaxed.owl UBERON:0005711 biolink:NamedThing foregut duodenum mesentery A mesentery of duodenum that is part of a foregut. RBO_relaxed.owl UBERON:0005712 biolink:NamedThing midgut duodenum mesentery A mesentery of duodenum that is part of a midgut. RBO_relaxed.owl UBERON:0005720 biolink:NamedThing hindbrain venous system A venous system that is part of a hindbrain. RBO_relaxed.owl UBERON:0006311 biolink:NamedThing chamber of eyeball A segment of the eyeball that is filled with refractive media. RBO_relaxed.owl UBERON:0006574 biolink:NamedThing pectinate line The pectinate line (anocutaneous line, dentate line, anorectal junction) is a line which divides the upper 2/3rds and lower 1/3rd of the anal canal. Developmentally, this line represents the hindgut-proctodeum junction. It is an important anatomical landmark, and several distinctions can be made based upon the location of a structure relative to this line:. RBO_relaxed.owl UBERON:0006761 biolink:NamedThing corneo-scleral junction The edge of the cornea where it joins the sclera; the limbus is a common site for the occurrence of corneal epithelial neoplasm. RBO_relaxed.owl UBERON:0009127 biolink:NamedThing epibranchial ganglion Cranial ganglion which develops from an epibranchial placode. RBO_relaxed.owl UBERON:0010230 biolink:NamedThing eyeball of camera-type eye The core globe-shaped component of the camera-type eye. RBO_relaxed.owl UBERON:0010286 biolink:NamedThing midbrain neural tube Portion of neural tube that gives rise to the midbrain. RBO_relaxed.owl UBERON:0010371 biolink:NamedThing ecto-epithelium Epithelium composed of cells that develops from the ectoderm[FMA,modified]. RBO_relaxed.owl UBERON:0010409 biolink:NamedThing ocular surface region The integrated unit (of the eye) that consists of the conjunctiva, the corneal surface, and the ocular mucosal adnexa including the lid margins and the meibomian gland openings, the lacrimal glands and the lacrimal drainage system, all which are critical to maintain ocular surface integrity and provide protection from external antigens and pathogenic microorganisms. RBO_relaxed.owl UBERON:0010427 biolink:NamedThing ciliary processes The ciliary processes are formed by the inward folding of the various layers of the choroid, i.e. , the choroid proper and the lamina basalis, and are received between corresponding foldings of the suspensory ligament of the lens. RBO_relaxed.owl UBERON:0011215 biolink:NamedThing central nervous system cell part cluster A multi cell part structure that is part of a central nervous system. RBO_relaxed.owl UBERON:0011892 biolink:NamedThing anterior uvea Front (ventral) portion of the vascular, pigmentary, or middle coat of the eye, including the ciliary body and the iris. RBO_relaxed.owl UBERON:0012490 biolink:NamedThing muscle layer of anal canal A muscular coat that is part of a anal canal. RBO_relaxed.owl UBERON:0013704 biolink:NamedThing notochordal canal A tubular passage that extends from the primitive pit into the head process during the early stages of embryonic development in mammals. It perforates the splanchnopleure layer so that the yolk sac and the amnion are connected temporarily. RBO_relaxed.owl UBERON:0016854 biolink:NamedThing dorsal part of optic cup The dorsal region of the optic cup that gives rise to the dorsal part of the retina. RBO_relaxed.owl UBERON:0018239 biolink:NamedThing rhombomere boundary A boundary delimiting a rhombomere. RBO_relaxed.owl UBERON:0019207 biolink:NamedThing chorioretinal region The part of the eye that consists of both the retina and the optic choroid. RBO_relaxed.owl UBERON:0036362 biolink:NamedThing wall of anal canal RBO_relaxed.owl UBERON:0036925 biolink:NamedThing wall of eyeball RBO_relaxed.owl CL:0000100 biolink:NamedThing motor neuron An efferent neuron that passes from the central nervous system or a ganglion toward or to a muscle and conducts an impulse that causes or inhibits movement. RBO_relaxed.owl CL:0000152 biolink:NamedThing exocrine cell A cell of an exocrine gland; i.e. a gland that discharges its secretion via a duct. RBO_relaxed.owl CL:0000154 biolink:NamedThing protein secreting cell RBO_relaxed.owl CL:0000159 biolink:NamedThing seromucus secreting cell RBO_relaxed.owl CL:0000167 biolink:NamedThing peptide hormone secreting cell RBO_relaxed.owl CL:0000168 biolink:NamedThing insulin secreting cell RBO_relaxed.owl CL:0000170 biolink:NamedThing glucagon secreting cell A cell that secretes glucagon. RBO_relaxed.owl CL:0000172 biolink:NamedThing somatostatin secreting cell RBO_relaxed.owl CL:0000174 biolink:NamedThing steroid hormone secreting cell RBO_relaxed.owl CL:0000319 biolink:NamedThing mucus secreting cell RBO_relaxed.owl CL:0000447 biolink:NamedThing carbohydrate secreting cell RBO_relaxed.owl CL:0000457 biolink:NamedThing biogenic amine secreting cell RBO_relaxed.owl CL:0000458 biolink:NamedThing serotonin secreting cell A cell type that secretes 5-Hydroxytryptamine (serotonin). RBO_relaxed.owl CL:0000459 biolink:NamedThing noradrenergic cell A cell capable of producting norepiniphrine. Norepiniphrine is a catecholamine with multiple roles including as a hormone and a neurotransmitter. In addition, epiniphrine is synthesized from norepiniphrine by the actions of the phenylethanolamine N-methyltransferase enzyme. RBO_relaxed.owl CL:0000593 biolink:NamedThing androgen secreting cell A steroid hormone secreting cell that secretes androgen. RBO_relaxed.owl CL:0000125 biolink:NamedThing glial cell A non-neuronal cell of the nervous system. They not only provide physical support, but also respond to injury, regulate the ionic and chemical composition of the extracellular milieu. Guide neuronal migration during development, and exchange metabolites with neurons. RBO_relaxed.owl CL:0000133 biolink:NamedThing neurectodermal cell Ectoderm destined to be nervous tissue. RBO_relaxed.owl CL:0000355 biolink:NamedThing multi-potent skeletal muscle stem cell A multifate stem cell found in skeletal muscle than can differentiate into many different cell types, including muscle. Distinct cell type from satellite cell. RBO_relaxed.owl CL:0002183 biolink:NamedThing stem cell of gastric gland A stomach epithelial cell that is olumnar in form with a few short apical microvilli; relatively undifferentiated mitotic cell from which other types of gland are derived; few in number, situated in the isthmus region of the gland and base of the gastric pit. RBO_relaxed.owl CL:0002664 biolink:NamedThing cardioblast A stem cell that can give rise to multiple cell types (i.e. smooth muscle, endothelial) in the developing heart. RBO_relaxed.owl CL:0005026 biolink:NamedThing hepatoblast Multi fate stem cell that gives rise to both hepatocytes and cholangiocytes as descendants. The term often refers to fetal precursors of hepatocytes (differently from 'hepatic stem cell', usually applied to the self-renewing pool of hepatocyte precursors in the adult liver). Hepatoblasts may also be endogenous, as some stem cells found in the liver come from the bone marrow via blood circulation. RBO_relaxed.owl CL:0000147 biolink:NamedThing pigment cell A pigment cell is a cell that contains pigment granules. RBO_relaxed.owl CL:0000306 biolink:NamedThing crystallin accumulating cell RBO_relaxed.owl CL:0000138 biolink:NamedThing chondrocyte Skeletogenic cell that is terminally differentiated, secretes an avascular, GAG-rich matrix, is embedded in cartilage tissue matrix, retains the ability to divide, and develops from a chondroblast cell. RBO_relaxed.owl CL:0000153 biolink:NamedThing glycosaminoglycan secreting cell A cell that secretes glycosaminoglycans. RBO_relaxed.owl CL:0000667 biolink:NamedThing collagen secreting cell An extracellular matrix secreting cell that secretes collagen. RBO_relaxed.owl CL:0000149 biolink:NamedThing visual pigment cell RBO_relaxed.owl CL:0000327 biolink:NamedThing extracellular matrix secreting cell RBO_relaxed.owl CL:0000164 biolink:NamedThing enteroendocrine cell An endocrine cell that is located in the epithelium of the gastrointestinal tract or in the pancreas. RBO_relaxed.owl CL:0000622 biolink:NamedThing acinar cell A secretory cell that is grouped together with other cells of the same type to form grape shaped clusters known as acini (singular acinus). RBO_relaxed.owl CL:0002657 biolink:NamedThing glandular cell of esophagus A glandular epithelial cell of the esophagus. RBO_relaxed.owl CL:0002658 biolink:NamedThing glandular cell of the large intestine A glandular epithelial cell of the large intestine. RBO_relaxed.owl CL:0002659 biolink:NamedThing glandular cell of stomach A glandular epithelial cell that is part of the stomach. RBO_relaxed.owl CL:1001588 biolink:NamedThing colon glandular cell Glandular cell of colon epithelium. Example: Goblet cells; enterocytes or absorptive cells; enteroendocrine and M cells. RBO_relaxed.owl CL:1001589 biolink:NamedThing duodenum glandular cell Glandular cell of duodenal epithelium. Example: Enterocytes, Goblet cells, enteroendocrine cells; Paneth cells; M cells; Brunner's gland cell. RBO_relaxed.owl CL:1001592 biolink:NamedThing gallbladder glandular cell Glandular cell of gallbladder epithelium. RBO_relaxed.owl CL:1001595 biolink:NamedThing rectum glandular cell Glandular cell of rectal epithelium. Example: Goblet cell; enterocytes or absorptive cells; enteroendocrine and M cells. RBO_relaxed.owl CL:1001598 biolink:NamedThing small intestine glandular cell A glandular cell found in the epithelium of the small intestine. Example: Enterocytes, Goblet cells, enteroendocrine cells; Paneth cells; M cells; Somatostatin-secreting Cells (D-cells) . RBO_relaxed.owl CL:1001599 biolink:NamedThing pancreas exocrine glandular cell Glandular cell of exocrine pancreas epithelium. Example: pancreatic acinar cell, glandular cells in pancreatic canaliculi, glandular cells in pancreatic ducts. RBO_relaxed.owl CL:0002074 biolink:NamedThing myocardial endocrine cell The myoendocrine cellis a specialized myocyte localized mainly in the right and left atrial appendages, and also scattered within other areas of the atria and along the conductive system in the ventricular septum. The most conspicuous feature distinguishing myoendocrine cells from other atrial myoctyes is the presence of membane-bounded secretory granules (these granules contain precursor of cardiodilatins or atrial natriuretic polypeptides). RBO_relaxed.owl CL:0008024 biolink:NamedThing pancreatic endocrine cell An endocrine cell that is part of the pancreas. RBO_relaxed.owl CL:0000710 biolink:NamedThing neurecto-epithelial cell Epithelial cells derived from neural plate and neural crest. RBO_relaxed.owl CL:0002088 biolink:NamedThing interstitial cell of Cajal This is a cell found in the gastrointestinal tract of mammals and serves as a pacemaker that triggers gut contraction. ICCs mediate inputs from the enteric nervous system to smooth muscle cells and are thought to be the cells from which gastrointestinal stromal tumors (GISTs) arise. RBO_relaxed.owl CL:0000507 biolink:NamedThing endorphin secreting cell A peptide hormone secreting cell that secretes endorphin. RBO_relaxed.owl CL:0000509 biolink:NamedThing gastrin secreting cell A peptide hormone secreting cell that secretes gastrin. RBO_relaxed.owl CL:0000696 biolink:NamedThing PP cell A cell that stores and secretes pancreatic polypeptide hormone. RBO_relaxed.owl CL:0000169 biolink:NamedThing type B pancreatic cell A cell that secretes insulin and is located towards the center of the islets of Langerhans. RBO_relaxed.owl CL:0000502 biolink:NamedThing type D enteroendocrine cell A cell found throughout the gastrointestinal tract and in the pancreas. They secrete somatostatin in both an endocrine and paracrine manner. Somatostatin inhibits gastrin, cholecystokinin, insulin, glucagon, pancreatic enzymes, and gastric hydrochloric acid. A variety of substances which inhibit gastric acid secretion (vasoactive intestinal peptide, calcitonin gene-related peptide, cholecystokinin, beta-adrenergic agonists, and gastric inhibitory peptide) are thought to act by releasing somatostatin. RBO_relaxed.owl CL:0000508 biolink:NamedThing type G enteroendocrine cell An endocrine cell found in the pyloric gland mucosa (antral mucosa) of the stomach of mammals and responsible for the secretion of gastrin and enkephalin. Most abundant in pyloric antrum, pyramidal in form with a narrow apex bearing long microvilli. RBO_relaxed.owl CL:0002067 biolink:NamedThing type A enteroendocrine cell An enteroendocrine cell that produces glucagon. RBO_relaxed.owl CL:0009006 biolink:NamedThing enteroendocrine cell of small intestine An enteroendocrine cell that is located in the small intestine. RBO_relaxed.owl CL:0009042 biolink:NamedThing enteroendocrine cell of colon An enteroendocrine cell that is located in the colon. RBO_relaxed.owl CL:0009063 biolink:NamedThing enteroendocrine cell of anorectum An enteroendocrine cell that is located in the anorectum. RBO_relaxed.owl CL:1000222 biolink:NamedThing stomach neuroendocrine cell RBO_relaxed.owl CL:1001516 biolink:NamedThing intestinal enteroendocrine cell The various hormone- or neurotransmitter-secreting cells present throughout the mucosa of the intestinal tract. RBO_relaxed.owl CL:0000171 biolink:NamedThing pancreatic A cell A type of enteocrine cell found in the periphery of the islets of Langerhans that secretes glucagon. RBO_relaxed.owl CL:0000173 biolink:NamedThing pancreatic D cell A D cell located in the pancreas. Peripherally placed within the islets like type A cells; contains somatostatin. RBO_relaxed.owl CL:0002275 biolink:NamedThing pancreatic PP cell A PP cell located in the islets of the pancreas. RBO_relaxed.owl CL:0002264 biolink:NamedThing type A cell of stomach A type of enteroendocrine cell found in the stomach that secretes glucagon. RBO_relaxed.owl CL:0002265 biolink:NamedThing type D cell of colon A D cell located in the colon. RBO_relaxed.owl CL:0002266 biolink:NamedThing type D cell of small intestine A type D cell of the small intestine. RBO_relaxed.owl CL:0002267 biolink:NamedThing type D cell of stomach A type D cell found in the stomach. RBO_relaxed.owl CL:0000417 biolink:NamedThing endopolyploid cell RBO_relaxed.owl CL:0000187 biolink:NamedThing muscle cell A mature contractile cell, commonly known as a myocyte. This cell has as part of its cytoplasm myofibrils organized in various patterns. RBO_relaxed.owl CL:0000393 biolink:NamedThing electrically responsive cell A cell whose function is determined by its response to an electric signal. RBO_relaxed.owl CL:0002092 biolink:NamedThing bone marrow cell A cell found in the bone marrow. This can include fibroblasts, macrophages, adipocytes, osteoblasts, osteoclasts, endothelial cells and hematopoietic cells. RBO_relaxed.owl CL:0002246 biolink:NamedThing peripheral blood stem cell A hematopoeitic stem cell found in the blood. Normally found in very limited numbers in the peripheral circulation (less than 0.1% of all nucleated cells). RBO_relaxed.owl CL:0002521 biolink:NamedThing subcutaneous adipocyte An adipocyte that is part of subcutaneous adipose tissue. RBO_relaxed.owl CL:0008022 biolink:NamedThing endocardial cushion cell A mesenchymal cell of the endocardial cushion. These cells develop via an epithelial to mesenchymal transition when endocardial cells break cell-to-cell contacts and migrate into the cardiac jelly. Cells from this population form the heart septa and valves. RBO_relaxed.owl CL:0010020 biolink:NamedThing cardiac glial cell RBO_relaxed.owl CL:1000309 biolink:NamedThing epicardial adipocyte An adipocyte that is part of the epicardial fat. RBO_relaxed.owl CL:2000001 biolink:NamedThing peripheral blood mononuclear cell A leukocyte with a single non-segmented nucleus in the mature form found in the circulatory pool of blood. RBO_relaxed.owl CL:2000074 biolink:NamedThing splenocyte Any leukocyte that is part of a spleen. RBO_relaxed.owl GO:0016528 biolink:NamedThing sarcoplasm The cytoplasm of a muscle cell; includes the sarcoplasmic reticulum. RBO_relaxed.owl GO:0030017 biolink:NamedThing sarcomere The repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs. RBO_relaxed.owl GO:0036194 biolink:NamedThing muscle cell projection A prolongation or process extending from a muscle cell. A muscle cell is a mature contractile cell, commonly known as a myocyte. This cell has as part of its cytoplasm myofibrils organized in various patterns. RBO_relaxed.owl GO:0036195 biolink:NamedThing muscle cell projection membrane The portion of the plasma membrane surrounding a muscle cell projection. RBO_relaxed.owl GO:0043292 biolink:NamedThing contractile fiber Fibers, composed of actin, myosin, and associated proteins, found in cells of smooth or striated muscle. RBO_relaxed.owl GO:0098975 biolink:NamedThing postsynapse of neuromuscular junction The postsynapse of a neuromuscular junction. In vertebrate muscles this includes the motor end-plate, consisting of postjunctional folds of the sarcolemma. RBO_relaxed.owl UBERON:0000948 biolink:NamedThing heart A myogenic muscular circulatory organ found in the vertebrate cardiovascular system composed of chambers of cardiac muscle. It is the primary circulatory organ. RBO_relaxed.owl UBERON:0001265 biolink:NamedThing trabecula of spleen A trabecula that is part of a spleen. RBO_relaxed.owl UBERON:0002099 biolink:NamedThing cardiac septum The thin membranous structure between the two heart atria or the thick muscular structure between the two heart ventricles. RBO_relaxed.owl UBERON:0002190 biolink:NamedThing subcutaneous adipose tissue A portion of adipose tissue that is part of the hypodermis, beneath the dermis. RBO_relaxed.owl UBERON:0002345 biolink:NamedThing descending thoracic aorta The part of the aorta that extends from the arch of the aorta to the diaphragm, and from which arises numerous branches that supply oxygenated blood to the chest cage and the organs within the chest. RBO_relaxed.owl UBERON:0002348 biolink:NamedThing epicardium A region of the serous membrane that forms the innermost layer of the pericardium and the outer surface of the heart. RBO_relaxed.owl UBERON:0002371 biolink:NamedThing bone marrow The soft tissue that fills the cavities of bones. RBO_relaxed.owl UBERON:0002376 biolink:NamedThing cranial muscle Any skeletal muscle that is part of the head region. RBO_relaxed.owl UBERON:0002385 biolink:NamedThing muscle tissue Muscle tissue is a contractile tissue made up of actin and myosin fibers[GO]. RBO_relaxed.owl UBERON:0002390 biolink:NamedThing hematopoietic system Anatomical system that is involved in the production of hematopoietic cells. RBO_relaxed.owl UBERON:0002511 biolink:NamedThing trabecula carnea The supporting bundles of muscular fibers lining the walls of the ventricles of the heart. RBO_relaxed.owl UBERON:0003081 biolink:NamedThing lateral plate mesoderm Portion of the middle of the three primary germ layers of the embryo that resides on the periphery of the embryo, is continuous with the extra-embryonic mesoderm, splits into two layers enclosing the intra-embryonic coelom, and gives rise to body wall structures[MP]. RBO_relaxed.owl UBERON:0003610 biolink:NamedThing heart elastic tissue The type of heart connective tissue found in the endocardial layer that consists mainly of elastic fibers. RBO_relaxed.owl UBERON:0003614 biolink:NamedThing blood vessel elastic tissue Elastic tissue layer that lines a blood vessel layer. RBO_relaxed.owl UBERON:0004140 biolink:NamedThing primary heart field A specific region of the lateral mesoderm that will form the primary beating heart tube. In mammals the primary heart field gives rise to the left ventricle. RBO_relaxed.owl UBERON:0004145 biolink:NamedThing outflow tract The outflow tract is the portion of the heart through which blood flows into the arteries. RBO_relaxed.owl UBERON:0004151 biolink:NamedThing cardiac chamber A cardiac chamber surrounds an enclosed cavity within the heart. RBO_relaxed.owl UBERON:0004177 biolink:NamedThing hemopoietic organ Organ that is part of the hematopoietic system. RBO_relaxed.owl UBERON:0004271 biolink:NamedThing outflow tract pericardium A pericardium that is part of a outflow tract [Automatically generated definition]. RBO_relaxed.owl UBERON:0004292 biolink:NamedThing cardiac skeleton Dense connective tissue that separates the atria from the ventricles and provides physical support for the heart. RBO_relaxed.owl UBERON:0004375 biolink:NamedThing bone of free limb or fin A bone that is part of an appendage [Automatically generated definition]. RBO_relaxed.owl UBERON:0004797 biolink:NamedThing blood vessel layer Any of the tissue layers that comprise a blood vessel. Examples: tunica media, tunica adventitia. RBO_relaxed.owl UBERON:0005498 biolink:NamedThing primitive heart tube Multi-tissue structure that arises from the heart rudiment and will become the heart tube. RBO_relaxed.owl UBERON:0005728 biolink:NamedThing extraembryonic mesoderm RBO_relaxed.owl UBERON:0005732 biolink:NamedThing paired limb/fin field A ring of cells capable of forming a limb or paired fin[Gilbert,modified]. RBO_relaxed.owl UBERON:0005800 biolink:NamedThing section of aorta Any portion of the aorta including the ascending and descending aorta, and aortic arch or a portion of the aortic orifice of the left ventricle. RBO_relaxed.owl UBERON:0005979 biolink:NamedThing crista terminalis The vertical crest of the interior wall of the right atrium that lies to the right of the sinus of the vena cava and separates this from the remainder of the right atrium. RBO_relaxed.owl UBERON:0005983 biolink:NamedThing heart layer The laminar structure of the heart. RBO_relaxed.owl UBERON:0005985 biolink:NamedThing coronary vessel Any of the arteries or veins that supply blood to the heart or return blood from the heart muscles to the circulation. RBO_relaxed.owl UBERON:0005988 biolink:NamedThing atrium myocardial trabecula The supporting bundles of muscular fibers lining the walls of the atrial myocardium. RBO_relaxed.owl UBERON:0006293 biolink:NamedThing spleen primordium A dense syncitial-like mesenchymal thickening in the dorsal mesogastrium[ISBN]. the embryonic connective tissue made up of loosely aggregated mesenchymal cells, supported by interlaminar jelly, that gives rise to the developing spleen[MP]. RBO_relaxed.owl UBERON:0006904 biolink:NamedThing head mesenchyme from mesoderm A head mesenchyme that develops_from a mesoderm. RBO_relaxed.owl UBERON:0007005 biolink:NamedThing cardiogenic splanchnic mesoderm The splanchnic mesoderm in the cardiogenic region where the heart develops; it gives rise to endocardial heart tubes that fuse to form the primordial cardiac tube, the heart primordium[web]. Two migratory heart primordia that move ventrally during the course of neurulation, and then fuse[XAO]. RBO_relaxed.owl UBERON:0007390 biolink:NamedThing pectoral appendage cartilage tissue A cartilage tissue that is part of a pectoral appendage. RBO_relaxed.owl UBERON:0007391 biolink:NamedThing pelvic appendage cartilage tissue A cartilage tissue that is part of a pelvic appendage. RBO_relaxed.owl UBERON:0007830 biolink:NamedThing pelvic girdle bone/zone A bone element or fused bone that is part of pelvic girdle. RBO_relaxed.owl UBERON:0007832 biolink:NamedThing pelvic girdle skeleton Skeletal subdivision consisting of a set of bones linking the axial series to the hindlimb zeugopodium and offering anchoring areas for hindlimb and caudal musculature. RBO_relaxed.owl UBERON:0008856 biolink:NamedThing stomach muscularis externa The smooth muscle layer of the stomach wall that functions to churn and mix food and gastric secretions as well as to move food along the digestive tract to the intestines. RBO_relaxed.owl UBERON:0008876 biolink:NamedThing hypodermis skeletal muscle layer Any skeletal muscle organ in the hypodermis / superficial fascia. RBO_relaxed.owl UBERON:0009751 biolink:NamedThing cardiac mesenchyme The embryonic connective tissue made up of loosely aggregated mesenchymal cells, supported by interlaminar jelly, that gives rise to the developing cardiac structures. RBO_relaxed.owl UBERON:0009881 biolink:NamedThing anterior lateral plate mesoderm RBO_relaxed.owl UBERON:0009889 biolink:NamedThing secondary heart field A specific region of the lateral mesoderm that will form the majority of the mesodermal component of the right ventricle, arterial pole (outflow tract) and venous pole (inflow tract). RBO_relaxed.owl UBERON:0010333 biolink:NamedThing extraembryonic membrane mesenchyme Mesenchyme that is part of a extraembryonic membrane. RBO_relaxed.owl UBERON:0010335 biolink:NamedThing maxillary process mesenchyme from head mesenchyme Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a maxillary process mesenchyme. RBO_relaxed.owl UBERON:0010360 biolink:NamedThing pharyngeal arch mesenchyme from head mesenchyme Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a entire pharyngeal arch associated mesenchyme. RBO_relaxed.owl UBERON:0010377 biolink:NamedThing mesenchyme from somatopleure Mesenchyme that develops_from a somatopleure. RBO_relaxed.owl UBERON:0010378 biolink:NamedThing mesenchyme from splanchnopleure Mesenchyme that develops_from a splanchnopleure. RBO_relaxed.owl UBERON:0011222 biolink:NamedThing intra-ocular muscle RBO_relaxed.owl UBERON:0011582 biolink:NamedThing paired limb/fin skeleton The collection of all skeletal elements in an individual limb or fin. RBO_relaxed.owl UBERON:0011820 biolink:NamedThing atrioventricular region An anatomical junction that divides and overlaps with and atrium and a ventricle in the heart. RBO_relaxed.owl UBERON:0011861 biolink:NamedThing aorta collagen fibril The connective tissue bundles in the extracellular matrix of aorta tissue that are composed of collagen, and play a role in tissue strength and elasticity. RBO_relaxed.owl UBERON:0011899 biolink:NamedThing epimysium Epimysium is a layer of connective tissue which ensheaths the entire muscle. It is composed of dense irregular connective tissue. It is continuous with fascia and other connective tissue wrappings of muscle including the endomysium, and perimysium. It is also continuous with tendons where it becomes thicker and collagenous. RBO_relaxed.owl UBERON:0012275 biolink:NamedThing meso-epithelium Epithelium that derives from the mesoderm. [Automatically generated definition]. RBO_relaxed.owl UBERON:0012429 biolink:NamedThing hematopoietic tissue Blood-forming tissue, consisting of reticular fibers and cells. RBO_relaxed.owl UBERON:0015129 biolink:NamedThing epicardial fat Visceral intrapericardial fat contiguous with the myocardial surface. RBO_relaxed.owl UBERON:0022350 biolink:NamedThing visceral serous membrane Serous membrane layer that is adjacent to and lines an organ. RBO_relaxed.owl UBERON:0022351 biolink:NamedThing parietal serous membrane Serous membrane layer that lines to a body cavity. RBO_relaxed.owl UBERON:0035965 biolink:NamedThing wall of blood vessel RBO_relaxed.owl UBERON:0036146 biolink:NamedThing cardiopharyngeal field An region of the mesoderm that includes anterior lateral mesoderm of the first heart field plus contiguous pharyngeal mesoderm that gives rise to second-heart-field-derived regions of the heart and branchiomeric muscles. RBO_relaxed.owl UBERON:0037144 biolink:NamedThing wall of heart Wall of organ which has as its parts the endocardium, myocardium , epicardium, and the cardiac septum, surrounded by the pericardial sac proper and is continuous with the walls of the systemic and pulmonary arterial and venous trees. RBO_relaxed.owl UBERON:1000024 biolink:NamedThing parenchyma of spleen A parenchyma that is part of a spleen. RBO_relaxed.owl UBERON:8480026 biolink:NamedThing skin of iliac crest region A zone of skin that is above the iliac crest in the pelvic girdle bone/zone. RBO_relaxed.owl CL:0008000 biolink:NamedThing non-striated muscle cell Any muscle cell in which the fibers are not organised into sarcomeres. RBO_relaxed.owl CL:0008007 biolink:NamedThing visceral muscle cell A muscle cell that is part of some visceral muscle. RBO_relaxed.owl CL:0008008 biolink:NamedThing striated visceral muscle cell A visceral muscle cell that is striated. Examples include the visceral muscle cells of arhtropods. RBO_relaxed.owl CL:0008009 biolink:NamedThing transversely striated visceral muscle cell A visceral muscle that is transversely striated. Examples include the visceral muscle cells of arthropods. RBO_relaxed.owl CL:1000223 biolink:NamedThing lung neuroendocrine cell A neuroendocrine cell that is part of respiratory epithelium of the lung and is involved in the sensory detection of environmental stimuli, including hypoxia, nicotine and air pressure. Ultrastructurally, this cell type is characterized by the presence of cytoplasmic dense core granules, which are considered the storage sites of amine and peptide hormones. Lung neuroendocrine cells are innervated and appear as solitary cells or as clustered masses, localized at airway bifurcation sites, called neuroepithelial bodies that can release serotonin in response to hypoxia and interact with sensory nerve terminals. Lung neuroendocrine cells also function as reserve stem cells that repair the surrounding epithelium after injury. RBO_relaxed.owl CL:0000562 biolink:NamedThing nucleate erythrocyte An erythrocyte having a nucleus. RBO_relaxed.owl CL:0002421 biolink:NamedThing nucleated reticulocyte A reticulocyte that retains the nucleus and other organelles. Found in birds, fish, amphibians and reptiles. RBO_relaxed.owl CL:0000525 biolink:NamedThing syncytiotrophoblast cell A cell from the outer syncytial layer of the trophoblast of an early mammalian embryo, directly associated with the maternal blood supply. It secretes hCG in order to maintain progesterone secretion and sustain a pregnancy. RBO_relaxed.owl CL:0002372 biolink:NamedThing myotube A transversely striated, synctial muscle cell, formed by the fusion of myoblasts. RBO_relaxed.owl CL:0000287 biolink:NamedThing eye photoreceptor cell RBO_relaxed.owl CL:0000488 biolink:NamedThing visible light photoreceptor cell A photoreceptor cell that detects visible light. RBO_relaxed.owl CL:2000019 biolink:NamedThing compound eye photoreceptor cell Any photoreceptor cell that is part of a compound eye. RBO_relaxed.owl CL:0000313 biolink:NamedThing serous secreting cell Columnar glandular cell with irregular nucleus, copious granular endoplasmic reticulum and supranuclear granules. Secretes a watery fluid containing proteins known as serous fluid. RBO_relaxed.owl CL:0002132 biolink:NamedThing stromal cell of ovary A stomal cell of the ovary RBO_relaxed.owl CL:0002574 biolink:NamedThing stromal cell of pancreas A stromal cell of the pancreas. RBO_relaxed.owl CL:0009021 biolink:NamedThing stromal cell of lamina propria of large intestine A stromal cell found in the lamina propria of the large intestine. RBO_relaxed.owl CL:0009022 biolink:NamedThing stromal cell of lamina propria of small intestine A stromal cell found in the lamina propria of the small intestine. RBO_relaxed.owl CL:0009040 biolink:NamedThing stromal cell of lamina propria of colon A stromal cell found in the lamina propria of the colon. RBO_relaxed.owl CL:0009053 biolink:NamedThing stromal cell of anorectum lamina propria A stromal cell found in the lamina propria of the anorectum. RBO_relaxed.owl CL:0010001 biolink:NamedThing stromal cell of bone marrow A stromal cell that is part_of a bone marrow. RBO_relaxed.owl CL:0008019 biolink:NamedThing mesenchymal cell A non-polarised cell precursor cell that is part of some mesenchyme, is associated with the cell matrix but is not connected to other cells and is capable of migration. RBO_relaxed.owl CL:0000335 biolink:NamedThing mesenchyme condensation cell A mesenchymal cell in embryonic development found in a contracting mass and that gives rise to osteoprogenitors. RBO_relaxed.owl CL:0000569 biolink:NamedThing cardiac mesenchymal cell A mesenchymal cell found in the developing heart and that develops into some part of the heart. These cells derive from intra- and extra-cardiac sources, including the endocardium, epicardium, neural crest, and second heart field. RBO_relaxed.owl CL:0000351 biolink:NamedThing trophoblast cell A cell lining the outside of the blastocyst. After binding to the endometrium, trophoblast cells develop into two distinct layers, an inner layer of mononuclear cytotrophoblast cells and an outer layer of continuous multinuclear cytoplasm, the syncytiotrophoblast cells, which form the early fetal-maternal interface. RBO_relaxed.owl CL:1000274 biolink:NamedThing trophectodermal cell RBO_relaxed.owl CL:0000352 biolink:NamedThing epiblast cell A cell of the outer layer of a blastula that gives rise to the ectoderm after gastrulation. RBO_relaxed.owl CL:0000353 biolink:NamedThing blastoderm cell An undifferentiated cell produced by early cleavages of the fertilized egg (zygote). RBO_relaxed.owl CL:0008002 biolink:NamedThing skeletal muscle fiber A transversely striated, synctial cell of skeletal muscle. It is formed when proliferating myoblasts exit the cell cycle, differentiate and fuse. RBO_relaxed.owl CL:0008017 biolink:NamedThing adult skeletal muscle myoblast A skeletal muscle myoblast that is part of a skeletal mucle. These cells are formed following acivation and division of skeletal muscle satellite cells. They form a transient population that is lost when they fuse to form skeletal muscle fibers. RBO_relaxed.owl CL:0008034 biolink:NamedThing mural cell Mural cells are pericytes and the vascular smooth muscle cells (vSMCs) of the microcirculation. RBO_relaxed.owl CL:0002159 biolink:NamedThing general ecto-epithelial cell Epithelial cells derived from general body ectoderm and ectoderm placodes. RBO_relaxed.owl CL:0000404 biolink:NamedThing electrically signaling cell A cell that initiates an electrical signal and passes that signal to another cell. RBO_relaxed.owl CL:0000397 biolink:NamedThing ganglion interneuron RBO_relaxed.owl CL:0000402 biolink:NamedThing CNS interneuron An interneuron that has its cell body in a central nervous system. RBO_relaxed.owl CL:0005000 biolink:NamedThing spinal cord interneuron A CNS interneuron located in the spinal cord. RBO_relaxed.owl CL:0002610 biolink:NamedThing raphe nuclei neuron A neuron of the raphe nuclei. RBO_relaxed.owl CL:0002612 biolink:NamedThing neuron of the ventral spinal cord A neuron of the ventral spinal cord. RBO_relaxed.owl CL:0011001 biolink:NamedThing spinal cord motor neuron A motor neuron that passes from the spinal cord toward or to a muscle and conducts an impulse that causes movement. RBO_relaxed.owl CL:0000506 biolink:NamedThing enkephalin secreting cell An endorphine cell that secretes enkephalin. RBO_relaxed.owl CL:0002180 biolink:NamedThing mucous cell of stomach A mucous cell in the epithelium of the stomach. RBO_relaxed.owl CL:0000513 biolink:NamedThing cardiac muscle myoblast A precursor cell destined to differentiate into cardiac muscle cell. RBO_relaxed.owl CL:0000514 biolink:NamedThing smooth muscle myoblast A precursor cell destined to differentiate into smooth muscle myocytes. RBO_relaxed.owl CL:0010021 biolink:NamedThing cardiac myoblast RBO_relaxed.owl CL:0000746 biolink:NamedThing cardiac muscle cell Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. In mammals, the contractile fiber resembles those of skeletal muscle but are only one third as large in diameter, are richer in sarcoplasm, and contain centrally located instead of peripheral nuclei. RBO_relaxed.owl CL:0010008 biolink:NamedThing cardiac endothelial cell RBO_relaxed.owl CL:0011019 biolink:NamedThing mesothelial cell of epicardium A mesothelial cell that is part of the epicardium. RBO_relaxed.owl CL:0000552 biolink:NamedThing orthochromatic erythroblast The final stage of the nucleated, immature erythrocyte, before nuclear loss. Typically the cytoplasm is described as acidophilic, but it still shows a faint polychromatic tint. The nucleus is small and initially may still have coarse, clumped chromatin, as in its precursor, the polychromatophilic erythroblast, but ultimately it becomes pyknotic, and appears as a deeply staining, blue-black, homogeneous structureless mass. The nucleus is often eccentric and sometimes lobulated. RBO_relaxed.owl CL:0000595 biolink:NamedThing enucleate erythrocyte An erythrocyte lacking a nucleus. RBO_relaxed.owl CL:0002540 biolink:NamedThing mesenchymal stem cell of the bone marrow A mesenchymal stem cell that is part of the bone marrow. RBO_relaxed.owl CL:0002570 biolink:NamedThing mesenchymal stem cell of adipose tissue A mesenchymal stem cell of adipose tissue. RBO_relaxed.owl CL:0002571 biolink:NamedThing hepatic mesenchymal stem cell A mesenchymal stem cell of liver. RBO_relaxed.owl CL:0002572 biolink:NamedThing vertebral mesenchymal stem cell A mesenchymal stem cell of the vertebrae. RBO_relaxed.owl CL:0000573 biolink:NamedThing retinal cone cell One of the two photoreceptor cell types in the vertebrate retina. In cones the photopigment is in invaginations of the cell membrane of the outer segment. Cones are less sensitive to light than rods, but they provide vision with higher spatial and temporal acuity, and the combination of signals from cones with different pigments allows color vision. RBO_relaxed.owl CL:0000604 biolink:NamedThing retinal rod cell One of the two photoreceptor cell types of the vertebrate retina. In rods the photopigment is in stacks of membranous disks separate from the outer cell membrane. Rods are more sensitive to light than cones, but rod mediated vision has less spatial and temporal resolution than cone vision. RBO_relaxed.owl CL:0002422 biolink:NamedThing enucleated reticulocyte A reticulocyte lacking a nucleus and showing a basophilic reticulum under vital staining due to the presence of ribosomes. RBO_relaxed.owl CL:0002224 biolink:NamedThing lens epithelial cell A cell of the cuboidal epithelium that covers the lens. The cells of the lens epithelium regulate most of the homeostatic functions of the lens. As ions, nutrients, and liquid enter the lens from the aqueous humor, Na+/K+ ATPase pumps in the lens epithelial cells pump ions out of the lens to maintain appropriate lens osmolarity and volume, with equatorially positioned lens epithelium cells contributing most to this current. The activity of the Na+/K+ ATPases keeps water and current flowing through the lens from the poles and exiting through the equatorial regions. The cells of the lens epithelium also serve as the progenitors for new lens fibers. It constantly lays down fibers in the embryo, fetus, infant, and adult, and continues to lay down fibers for lifelong growth. RBO_relaxed.owl CL:0000737 biolink:NamedThing striated muscle cell Muscle cell which has as its direct parts myofilaments organized into sarcomeres. RBO_relaxed.owl CL:1000409 biolink:NamedThing myocyte of sinoatrial node A muscle cell that is part of the sinoatrial node. RBO_relaxed.owl CL:1000410 biolink:NamedThing myocyte of atrioventricular node A muscle cell that is part of the atrioventricular node. RBO_relaxed.owl CL:0000740 biolink:NamedThing retinal ganglion cell The set of neurons that receives neural inputs via bipolar, horizontal and amacrine cells. The axons of these cells make up the optic nerve. RBO_relaxed.owl CL:0000842 biolink:NamedThing mononuclear cell A leukocyte with a single non-segmented nucleus in the mature form. RBO_relaxed.owl CL:0002087 biolink:NamedThing nongranular leukocyte A leukocyte that lacks granules. RBO_relaxed.owl CL:0002064 biolink:NamedThing pancreatic acinar cell A secretory cell found in pancreatic acini that secretes digestive enzymes and mucins. This cell is a typical zymogenic cell, have a basal nucleus and basophilic cytoplasm consisting of regular arrays of granular endoplasmic reticulum with mitochondria and dense secretory granules. RBO_relaxed.owl CL:0002068 biolink:NamedThing Purkinje myocyte Specialized cardiac myocyte that is subendocardially interspersed with the regular cardiac muscle cell. They are uninucleate cylindrical cells, associated end-to-end in long rows, continue from the node to the atrioventricular bundle; relatively short compared to ordinary myocytes but are nearly twice their diameter. RBO_relaxed.owl CL:0002086 biolink:NamedThing specialized cardiac myocyte A cardiac myocyte that is an excitable cells in the myocardium, specifically in the conducting system of heart. RBO_relaxed.owl CL:0002072 biolink:NamedThing nodal myocyte A specialized cardiac myocyte in the sinoatrial and atrioventricular nodes. The cell is slender and fusiform confined to the nodal center, circumferentially arranged around the nodal artery. RBO_relaxed.owl CL:0002073 biolink:NamedThing transitional myocyte Specialized cardiac myocyte which is in the internodal tract and atrioventricular node. The cell is more slender than ordinary atrial myocytes and has more myofibrils than nodal myocytes. RBO_relaxed.owl CL:0002079 biolink:NamedThing pancreatic ductal cell Epithelial cell found in the ducts of the pancreas. This cell type contributes to the high luminal pH. RBO_relaxed.owl CL:0002080 biolink:NamedThing pancreatic centro-acinar cell A cubodial epithelial cell that is continuous with the lining of intercalated ducts that drain the acinus. This cell type secretes a high pH solution to aid in activation of zymogens, and can differentiate into endocrine and exocrine pancreatic cell types. RBO_relaxed.owl CL:2000046 biolink:NamedThing ventricular cardiac muscle cell Any cardiac muscle cell that is part of a cardiac ventricle. RBO_relaxed.owl CL:0002095 biolink:NamedThing hilus cell of ovary A cell in the hilum of the ovary that produces androgens. RBO_relaxed.owl CL:0002262 biolink:NamedThing endothelial cell of sinusoid An endothelial cell that lines any of the venous cavities through which blood passes in various glands and organs such as the spleen and liver. RBO_relaxed.owl CL:0002350 biolink:NamedThing endocardial cell An endothelial cell that lines the intracavitary lumen of the heart, separating the circulating blood from the underlying myocardium. This cell type releases a number of vasoactive substances including prostacyclin, nitrous oxide and endothelin. RBO_relaxed.owl CL:0009094 biolink:NamedThing endothelial cell of hepatic portal vein An endothelial cell that is part of a hepatic portal vein. RBO_relaxed.owl CL:1000398 biolink:NamedThing endothelial cell of hepatic sinusoid An endothelial cell that is part of the hepatic sinusoid. These cells possess flattened areas containing perforations about 0.1 micrometers in diameter, known as fenestrae. The fenestrae are arranged in groups known as sieve plates. RBO_relaxed.owl CL:1000412 biolink:NamedThing endothelial cell of arteriole An endothelial cell that is part of the arteriole. RBO_relaxed.owl CL:1000413 biolink:NamedThing endothelial cell of artery A blood vessel endothelial cell that is part of an arterial endothelium. RBO_relaxed.owl CL:1001572 biolink:NamedThing colon endothelial cell A vascular endothelial cell found in colon blood vessels. RBO_relaxed.owl CL:2000053 biolink:NamedThing splenic endothelial cell Any endothelial cell that is part of a spleen. RBO_relaxed.owl CL:4033061 biolink:NamedThing endothelial cell of central vein of liver An endothelial cell that is part of a central vein of liver. RBO_relaxed.owl CL:0002144 biolink:NamedThing capillary endothelial cell An endothelial cell found in capillaries. RBO_relaxed.owl CL:0002543 biolink:NamedThing vein endothelial cell An endothelial cell that is part of the vein. RBO_relaxed.owl CL:0010006 biolink:NamedThing cardiac blood vessel endothelial cell RBO_relaxed.owl CL:2000008 biolink:NamedThing microvascular endothelial cell Any blood vessel endothelial cell that is part of a microvascular endothelium. RBO_relaxed.owl CL:0011030 biolink:NamedThing dermal microvascular endothelial cell Any microvascular endothelial cell that is part of the dermis. RBO_relaxed.owl CL:2000016 biolink:NamedThing lung microvascular endothelial cell Any lung endothelial cell that is part of a microvascular endothelium. RBO_relaxed.owl CL:0002352 biolink:NamedThing gestational hematopoietic stem cell A hematopoietic stem cell that exists during embryogenesis. RBO_relaxed.owl CL:0002368 biolink:NamedThing respiratory epithelial cell An endo-epithelial cell of the respiratory tract. RBO_relaxed.owl CL:0002253 biolink:NamedThing epithelial cell of large intestine An epithelial cell of the large intestine. RBO_relaxed.owl CL:0002254 biolink:NamedThing epithelial cell of small intestine An epithelial cell of the small intestine. RBO_relaxed.owl CL:0002680 biolink:NamedThing PP cell of intestine A PP cell found in intestine. RBO_relaxed.owl CL:0002538 biolink:NamedThing intrahepatic cholangiocyte An epithelial cell of the intrahepatic portion of the bile duct. These cells are flattened or cuboidal in shape, and have a small nuclear-to-cytoplasmic ratio relative to large/extrahepatic cholangiocytes. RBO_relaxed.owl CL:0019020 biolink:NamedThing extrahepatic cholangiocyte An epithelial cell of the extrahepatic bile ducts, including the left and right hepatic duct, common hepatic duct, and common bile duct. They are columnar in shape, and have a large nuclear-to-cytoplasmic ratio relative to small/intrahepatic cholangiocytes. RBO_relaxed.owl CL:0002539 biolink:NamedThing aortic smooth muscle cell A smooth muscle cell of the aorta. RBO_relaxed.owl CL:0002589 biolink:NamedThing smooth muscle cell of the brachiocephalic vasculature A smooth muscle cell of the bachiocephalic vasculature. RBO_relaxed.owl CL:0002591 biolink:NamedThing smooth muscle cell of the pulmonary artery A smooth muscle of the pulmonary artery. RBO_relaxed.owl CL:0002595 biolink:NamedThing smooth muscle cell of the subclavian artery A smooth muscle cell of the subclavian artery. RBO_relaxed.owl CL:0002596 biolink:NamedThing smooth muscle cell of the carotid artery Smooth muscle cell of the carotid artery. RBO_relaxed.owl CL:0008035 biolink:NamedThing microcirculation associated smooth muscle cell RBO_relaxed.owl CL:0002546 biolink:NamedThing embryonic blood vessel endothelial progenitor cell An endothelial progenitor cell that participates in angiogenesis during development. RBO_relaxed.owl CL:0011007 biolink:NamedThing paraxial cell A cell in the area of mesoderm in the neurulating embryo that flanks and forms simultaneously with the neural tube. The cells of this region give rise to somites. RBO_relaxed.owl CL:0002547 biolink:NamedThing fibroblast of the aortic adventitia A fibroblast of the aortic adventitia. RBO_relaxed.owl CL:0002551 biolink:NamedThing fibroblast of dermis RBO_relaxed.owl CL:2000013 biolink:NamedThing fibroblast of skin of abdomen Any skin fibroblast that is part of a skin of abdomen. RBO_relaxed.owl CL:0002632 biolink:NamedThing epithelial cell of lower respiratory tract RBO_relaxed.owl CL:3000000 biolink:NamedThing ciliated epithelial cell of esophagus A ciliated epithelial cell of the esophagus. RBO_relaxed.owl CL:0002663 biolink:NamedThing myocardial endocrine cell of atrium A myocardial endocrine cell that is part of the atrium. RBO_relaxed.owl CL:1000482 biolink:NamedThing myocardial endocrine cell of interventricular septum A myocardial endocrine cell that is part of the interventricular septum. RBO_relaxed.owl CL:0009024 biolink:NamedThing mesothelial cell of small intestine A mesothelial cell that is part of the small intestine. RBO_relaxed.owl CL:0009025 biolink:NamedThing mesothelial cell of colon A mesothelial cell that is part of the colon. RBO_relaxed.owl CL:1000456 biolink:NamedThing mesothelial cell of parietal peritoneum A mesothelial cell that is part of the parietal peritoneum. RBO_relaxed.owl CL:1000457 biolink:NamedThing mesothelial cell of visceral peritoneum A mesothelial cell that is part of the visceral peritoneum. RBO_relaxed.owl CL:1000490 biolink:NamedThing mesothelial cell of peritoneum A mesothelial cell that is part of the peritoneum. RBO_relaxed.owl CL:1000491 biolink:NamedThing mesothelial cell of pleura A mesothelial cell that is part of the pleura. RBO_relaxed.owl CL:1000492 biolink:NamedThing mesothelial cell of parietal pleura A mesothelial cell that is part of the parietal pleura. RBO_relaxed.owl CL:1000493 biolink:NamedThing mesothelial cell of visceral pleura A mesothelial cell that is part of the visceral pleura. RBO_relaxed.owl UBERON:0000114 biolink:NamedThing lung connective tissue The connective tissue located between the respiratory (airway and alveolar) epithelium, the capillary endothelium and pleural mesothelium; it contains basement membrane composed of collagen, elastin, proteoglycans, and fibronectin. RBO_relaxed.owl UBERON:0000977 biolink:NamedThing pleura The invaginated serous membrane that surrounds the lungs (the visceral portion) and lines the walls of the pleural cavity (parietal portion). RBO_relaxed.owl UBERON:0002400 biolink:NamedThing parietal pleura The outer serous membrane of the pulmonary pleural. RBO_relaxed.owl UBERON:0002401 biolink:NamedThing visceral pleura The inner serous membrane of the pulmonary pleural. The visceral pleura lines the lungs. RBO_relaxed.owl UBERON:0003512 biolink:NamedThing lung blood vessel A blood vessel that is part of a lung [Automatically generated definition]. RBO_relaxed.owl UBERON:0004233 biolink:NamedThing lower respiratory tract smooth muscle A portion of smooth muscle tissue that is part of a lower respiratory tract [Automatically generated definition]. RBO_relaxed.owl UBERON:0004240 biolink:NamedThing gallbladder smooth muscle A portion of smooth muscle tissue that is part of a gallbladder [Automatically generated definition]. RBO_relaxed.owl UBERON:0004783 biolink:NamedThing gallbladder serosa A serous membrane that is part of a gallbladder [Automatically generated definition]. RBO_relaxed.owl UBERON:0004834 biolink:NamedThing hepatic duct smooth muscle Smooth muscle tissue in all or part of a hepatic duct. RBO_relaxed.owl UBERON:0004883 biolink:NamedThing lung mesenchyme The mass of tissue made up of mesenchymal cells in the lung. RBO_relaxed.owl UBERON:0005672 biolink:NamedThing right lung endothelium An endothelium that is part of a right lung. RBO_relaxed.owl UBERON:0005673 biolink:NamedThing left lung endothelium An endothelium that is part of a left lung. RBO_relaxed.owl UBERON:0013479 biolink:NamedThing lung endothelium A blood vessel endothelium that is part of a lung [Automatically generated definition]. RBO_relaxed.owl UBERON:0015796 biolink:NamedThing liver blood vessel A blood vessel that is part of a liver. RBO_relaxed.owl UBERON:0036073 biolink:NamedThing respiratory primordium mesenchyme RBO_relaxed.owl UBERON:8400021 biolink:NamedThing liver serosa Hepatic serous coat; peritoneal covering of the liver, enclosing almost all except for a triangular area on its posterior surface (the 'bare area of the liver') and a smaller area where the liver and gallbladder are in direct contact. RBO_relaxed.owl CL:1000279 biolink:NamedThing smooth muscle cell of large intestine A smooth muscle cell that is part of the large intestine. RBO_relaxed.owl CL:1000280 biolink:NamedThing smooth muscle cell of colon A smooth muscle cell that is part of the colon. RBO_relaxed.owl CL:0009097 biolink:NamedThing embryonic skeletal muscle fiber A skeletal muscle fiber found in an embryo. In mammalian embryos, skeletal muscle expresses myosin heavy chain-embryonic (MyHC-emb, encoded by the MYH3 gene), which regulates skeletal muscle development. RBO_relaxed.owl CL:0010004 biolink:NamedThing mononuclear cell of bone marrow A mononuclear cell that is part_of a bone marrow. RBO_relaxed.owl CL:0017502 biolink:NamedThing acidophilic cytoplasm Cytoplasm that exhibits a characteristic staining and color, red or pink, with Eosin stain. RBO_relaxed.owl GO:0005737 biolink:NamedThing cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. RBO_relaxed.owl CL:0017503 biolink:NamedThing basophilic cytoplasm Cytoplasm that exhibits molecular interaction for basic dyes under specific pH conditions. RBO_relaxed.owl CL:0017504 biolink:NamedThing polychromatophilic cytoplasm Cytoplasm that exhibits affinity for both basic and acid stains under specific pH conditions. RBO_relaxed.owl GO:0005938 biolink:NamedThing cell cortex The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins. RBO_relaxed.owl GO:0032838 biolink:NamedThing plasma membrane bounded cell projection cytoplasm All of the contents of a plasma membrane bounded cell projection, excluding the plasma membrane surrounding the projection. RBO_relaxed.owl GO:0097014 biolink:NamedThing ciliary plasm All of the contents of a cilium, excluding the plasma membrane surrounding the cilium. RBO_relaxed.owl GO:0099568 biolink:NamedThing cytoplasmic region Any (proper) part of the cytoplasm of a single cell of sufficient size to still be considered cytoplasm. RBO_relaxed.owl GO:0120111 biolink:NamedThing neuron projection cytoplasm All of the contents of a plasma membrane bounded neuron projection, excluding the plasma membrane surrounding the projection. RBO_relaxed.owl GO:1990917 biolink:NamedThing ooplasm The cytoplasm of an ovum. RBO_relaxed.owl CL:0017505 biolink:NamedThing increased nucleus size A nucleus size quality which is relatively high compared to the amount of cytoplasm present in the same cell. RBO_relaxed.owl GO:0005634 biolink:NamedThing nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. RBO_relaxed.owl GO:0001674 biolink:NamedThing female germ cell nucleus The nucleus of the female germ cell, a reproductive cell in females. RBO_relaxed.owl GO:0043073 biolink:NamedThing germ cell nucleus The nucleus of a germ cell, a reproductive cell in multicellular organisms. RBO_relaxed.owl CL:0019021 biolink:NamedThing endothelial cell of periportal hepatic sinusoid An endothelial cell found in the periportal region hepatic sinusoid, near the portal triad. The fenestrae of these cells are larger but fewer in number compared with those of endothelial cells near the centrilobular region of the hepatic sinusoid. RBO_relaxed.owl CL:0019022 biolink:NamedThing endothelial cell of pericentral hepatic sinusoid An endothelial cell found in the centrilobular region hepatic sinusoid, near the central vein. The fenestrae of these cells are smaller but more numerous compared with those of endothelial cells near the periportal region of the hepatic sinusoid. RBO_relaxed.owl CL:1000275 biolink:NamedThing smooth muscle cell of small intestine A smooth muscle cell that is part of the small intestine. RBO_relaxed.owl CL:1000276 biolink:NamedThing smooth muscle fiber of duodenum A smooth muscle cell that is part of the duodenum. RBO_relaxed.owl CL:1000285 biolink:NamedThing smooth muscle cell of sigmoid colon A smooth muscle cell that is part of the sigmoid colon. RBO_relaxed.owl CL:1000310 biolink:NamedThing adipocyte of epicardial fat of right ventricle An adipocyte that is part of the epicardial fat of right ventricle. RBO_relaxed.owl CL:1000311 biolink:NamedThing adipocyte of epicardial fat of left ventricle An adipocyte that is part of the epicardial fat of left ventricle. RBO_relaxed.owl CL:1000361 biolink:NamedThing transitional myocyte of interatrial septum A transitional myocyte that is part of the interatrial septum. RBO_relaxed.owl CL:1000362 biolink:NamedThing transitional myocyte of interventricular septum A transitional myocyte that is part of the interventricular septum. RBO_relaxed.owl CL:1000478 biolink:NamedThing transitional myocyte of sinoatrial node A transitional myocyte that is part of the sinoatrial node. RBO_relaxed.owl CL:1000376 biolink:NamedThing Purkinje myocyte of interventricular septum A Purkinje myocyte that is part of the interventricular septum. RBO_relaxed.owl CL:1000479 biolink:NamedThing Purkinje myocyte of atrioventricular node A Purkinje myocyte that is part of the atrioventricular node. RBO_relaxed.owl CL:2000080 biolink:NamedThing mesenchymal stem cell of abdominal adipose tissue Any mesenchymal stem cell of adipose tissue that is part of an abdomen. RBO_relaxed.owl CL:4040004 biolink:NamedThing mesenchymal stem cell of orbital adipose tissue Any mesenchymal stem cell of adipose tissue that is part of an orbital region. RBO_relaxed.owl CL:4028001 biolink:NamedThing pulmonary capillary endothelial cell Any capillary endothelial cell that is part of a lung. RBO_relaxed.owl CL:4033008 biolink:NamedThing vein endothelial cell of respiratory system A(n) vein endothelial cell that is part of a(n) respiratory system. RBO_relaxed.owl OBO:COB_0000077 biolink:NamedThing action specification RBO_relaxed.owl IAO:0000033 biolink:NamedThing directive information entity An information content entity whose concretizations indicate to their bearer how to realize them in a process. RBO_relaxed.owl IAO:0000005 biolink:NamedThing objective specification A directive information entity that describes an intended process endpoint. When part of a plan specification the concretization is realized in a planned process in which the bearer tries to effect the world so that the process endpoint is achieved. RBO_relaxed.owl IAO:0000007 biolink:NamedThing action specification A directive information entity that describes an action the bearer will take. RBO_relaxed.owl IAO:0000096 biolink:NamedThing source code module A source code module is a directive information entity that specifies, using a programming language, some algorithm. RBO_relaxed.owl IAO:0000098 biolink:NamedThing data format specification A data format specification is the information content borne by the document published defining the specification. Example: The ISO document specifying what encompasses an XML document; The instructions in a XSD file RBO_relaxed.owl IAO:0000104 biolink:NamedThing plan specification A directive information entity with action specifications and objective specifications as parts that, when concretized, is realized in a process in which the bearer tries to achieve the objectives by taking the actions specified.|A directive information entity with action specifications and objective specifications as parts, and that may be concretized as a realizable entity that, if realized, is realized in a process in which the bearer tries to achieve the objectives by taking the actions specified. RBO_relaxed.owl DOID:0050161 biolink:NamedThing lower respiratory tract disease A respiratory system disease which involves the lower respiratory tract. RBO_relaxed.owl DOID:1579 biolink:NamedThing respiratory system disease A disease of anatomical entity that located_in the respiratory system which extends from the nasal sinuses to the diaphragm. RBO_relaxed.owl DOID:0050700 biolink:NamedThing cardiomyopathy A heart disease and a myopathy that is characterized by deterioration of the function of the heart muscle. RBO_relaxed.owl DOID:114 biolink:NamedThing heart disease A cardiovascular system disease that involves the heart. RBO_relaxed.owl DOID:10273 biolink:NamedThing heart conduction disease A cardiovascular system disease that involves the heart's electrical conduction system. RBO_relaxed.owl DOID:4079 biolink:NamedThing heart valve disease A heart disease involving one or more of the four valves of the heart (the aortic and mitral valves on the left and the pulmonary and tricuspid valves on the right). RBO_relaxed.owl DOID:0050851 biolink:NamedThing glomerulosclerosis A glomerulonephritis that is characterized by hardening of the glomerulus in the kidney. RBO_relaxed.owl DOID:2921 biolink:NamedThing glomerulonephritis A nephritis that causes inflammation of the glomeruli located_in kidney. RBO_relaxed.owl DOID:0050902 biolink:NamedThing medulloblastoma An infratentorial cancer that is located_in the lower part of the brain and is a type of primitive neuroectodermal tumor. RBO_relaxed.owl DOID:1319 biolink:NamedThing brain cancer A central nervous system cancer that is characterized by the growth of abnormal cells in the tissues of the brain. RBO_relaxed.owl DOID:0060037 biolink:NamedThing developmental disorder of mental health A disease of mental health that occur during a child's developmental period between birth and age 18 resulting in retarding of the child's psychological or physical development. RBO_relaxed.owl DOID:150 biolink:NamedThing disease of mental health A disease that involves a psychological or behavioral pattern generally associated with subjective distress or disability that occurs in an individual, and which are not a part of normal development or culture. RBO_relaxed.owl DOID:1510 biolink:NamedThing personality disorder A disease of mental health that involve long-term patterns of thoughts and behaviors that cause serious problems with relationships and work. RBO_relaxed.owl DOID:1561 biolink:NamedThing cognitive disorder A disease of mental health that affects cognitive functions including memory processing, perception and problem solving. RBO_relaxed.owl DOID:303 biolink:NamedThing substance-related disorder A disease of mental health involving the abuse or dependence on a substance that is ingested in order to produce a high, alter one's senses, or otherwise affect functioning. RBO_relaxed.owl DOID:4737 biolink:NamedThing somatoform disorder A disease of mental health that involves physical symptoms suggesting a physical illness where the biological or medical cause of the symptoms is indeterminate. RBO_relaxed.owl DOID:535 biolink:NamedThing sleep disorder A disease of mental health that involves disruption of sleep patterns. RBO_relaxed.owl DOID:0060058 biolink:NamedThing lymphoma A hematologic cancer that affects lymphocytes that reside in the lymphatic system and in blood-forming organs. RBO_relaxed.owl DOID:2531 biolink:NamedThing hematologic cancer An organ system cancer located in the hematological system that is characterized by uncontrolled cellular proliferation in blood, bone marrow and lymph nodes. RBO_relaxed.owl DOID:1240 biolink:NamedThing leukemia A cancer that affects the blood or bone marrow characterized by an abnormal proliferation of blood cells. RBO_relaxed.owl DOID:5621 biolink:NamedThing histiocytic and dendritic cell cancer A sarcoma and hematologic cancer that derives_from follicular lymphoma. RBO_relaxed.owl DOID:0060071 biolink:NamedThing pre-malignant neoplasm A disease of cellular proliferation that results in abnormal growths in the body, which do not invade or destroy the surrounding tissue but, given enough time, will transform into a cancer. RBO_relaxed.owl DOID:14566 biolink:NamedThing disease of cellular proliferation A disease that is characterized by abnormally rapid cell division. RBO_relaxed.owl DOID:0060072 biolink:NamedThing benign neoplasm A disease of cellular proliferation that results in abnormal growths in the body which lack the ability to metastasize. RBO_relaxed.owl DOID:162 biolink:NamedThing cancer A disease of cellular proliferation that is malignant and primary, characterized by uncontrolled cellular proliferation, local cell invasion and metastasis. RBO_relaxed.owl DOID:10124 biolink:NamedThing corneal disease An eye disease that affects the cornea, which is the transparent surface of the eye that assists in light refraction. RBO_relaxed.owl DOID:5614 biolink:NamedThing eye disease An eye and adnexa disease that is located_in the eye. RBO_relaxed.owl DOID:240 biolink:NamedThing iris disease RBO_relaxed.owl DOID:83 biolink:NamedThing cataract A lens disease characterized by clouding of the lens inside the eye which leads to a decrease in vision. RBO_relaxed.owl DOID:10286 biolink:NamedThing prostate carcinoma A prostate cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells. RBO_relaxed.owl DOID:10534 biolink:NamedThing stomach cancer A gastrointestinal system cancer that is located_in the stomach. RBO_relaxed.owl DOID:11054 biolink:NamedThing urinary bladder cancer An urinary system cancer that results_in malignant growth located_in the urinary bladder. RBO_relaxed.owl DOID:1115 biolink:NamedThing sarcoma A cell type cancer that has_material_basis_in abnormally proliferating cells derives from embryonic mesoderm. RBO_relaxed.owl DOID:1612 biolink:NamedThing breast cancer A thoracic cancer that originates in the mammary gland. RBO_relaxed.owl DOID:1909 biolink:NamedThing melanoma A cell type cancer that has_material_basis_in abnormally proliferating cells derives_from melanocytes which are found in skin, the bowel and the eye. RBO_relaxed.owl DOID:2394 biolink:NamedThing ovarian cancer A female reproductive organ cancer that is located_in the ovary. RBO_relaxed.owl DOID:2994 biolink:NamedThing germ cell cancer A cell type cancer that has_material_basis_in abnormally proliferating cells derives_from germ cells. RBO_relaxed.owl DOID:3451 biolink:NamedThing skin carcinoma A skin cancer that is located_in tissues of the skin and develops from epithelial cells. RBO_relaxed.owl DOID:3571 biolink:NamedThing liver cancer A hepatobiliary system cancer that is located_in the liver. RBO_relaxed.owl DOID:5041 biolink:NamedThing esophageal cancer A gastrointestinal system cancer that is located_in the esophagus. RBO_relaxed.owl DOID:6199 biolink:NamedThing cornea cancer RBO_relaxed.owl DOID:9256 biolink:NamedThing colorectal cancer A large intestine cancer that is located_in the colon and/or located_in the rectum. RBO_relaxed.owl DOID:1037 biolink:NamedThing lymphoid leukemia A leukemia that has_material_basis_in a B-cell or T-cell lineage involving primarily the bone marrow and the peripheral blood. RBO_relaxed.owl DOID:7757 biolink:NamedThing childhood leukemia A leukemia that occurs in children. RBO_relaxed.owl DOID:8692 biolink:NamedThing myeloid leukemia A leukemia that is located_in myeloid tissue. RBO_relaxed.owl DOID:1040 biolink:NamedThing chronic lymphocytic leukemia A lymphocytic leukemia characterized by over production of B-cells and their accumulation in bone marrow and blood. RBO_relaxed.owl DOID:9952 biolink:NamedThing acute lymphoblastic leukemia A acute leukemia that is characterized by over production of lymphoblasts. RBO_relaxed.owl DOID:10652 biolink:NamedThing Alzheimer's disease A tauopathy that is characterized by memory lapses, confusion, emotional instability and progressive loss of mental ability and results in progressive memory loss, impaired thinking, disorientation, and changes in personality and mood starting and leads in advanced cases to a profound decline in cognitive and physical functioning and is marked histologically by the degeneration of brain neurons especially in the cerebral cortex and by the presence of neurofibrillary tangles and plaques containing beta-amyloid. RBO_relaxed.owl DOID:7 biolink:NamedThing disease of anatomical entity A disease that manifests in a defined anatomical structure. RBO_relaxed.owl DOID:1247 biolink:NamedThing blood coagulation disease A hematopoietic system disease that is characterized by abnormal blood clotting or bleeding. RBO_relaxed.owl DOID:1287 biolink:NamedThing cardiovascular system disease A disease of anatomical entity which occurs in the blood, heart, blood vessels or the lymphatic system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells or lymph to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis. RBO_relaxed.owl DOID:1443 biolink:NamedThing cerebral degeneration A brain disease that is characterized by loss of structure or function of neurons, including death of neurons and loss of brain tissue. RBO_relaxed.owl DOID:2786 biolink:NamedThing cerebellar disease A brain disease that is characterized by damage to brain substance located_in cerebellum; has_symptom ataxia, has_symptom dysarthria, and has_symptom cerebellar cognitive affective syndrome. RBO_relaxed.owl DOID:28 biolink:NamedThing endocrine system disease A disease of anatomical entity that is located_in endocrine glands which secretes a type of hormone directly into the bloodstream to regulate the body. RBO_relaxed.owl DOID:37 biolink:NamedThing skin disease An integumentary system disease that is located_in skin. RBO_relaxed.owl DOID:403 biolink:NamedThing mouth disease A gastrointestinal system disease that is located_in the mouth. RBO_relaxed.owl DOID:409 biolink:NamedThing liver disease RBO_relaxed.owl DOID:4961 biolink:NamedThing bone marrow disease RBO_relaxed.owl DOID:5353 biolink:NamedThing colonic disease A intestinal disease located in the colon. RBO_relaxed.owl DOID:557 biolink:NamedThing kidney disease A urinary system disease that is located_in the kidney. RBO_relaxed.owl DOID:75 biolink:NamedThing lymphatic system disease An immune system disease that is located_in the lymphatic system. RBO_relaxed.owl DOID:178 biolink:NamedThing vascular disease A cardiovascular system disease that primarily affects the blood vessels which includes the arteries, veins and capillaries that carry blood to and from the heart. RBO_relaxed.owl DOID:1787 biolink:NamedThing pericarditis A pericardium disease that is characterized by an inflammation of the pericardium and has_symptom chest pain. RBO_relaxed.owl DOID:1176 biolink:NamedThing bronchial disease A lower respiratory tract disease that affects the airways leading into the lungs, which is caused due to inflammation of the bronchi and bronchioles, infection, or blockage. RBO_relaxed.owl DOID:1532 biolink:NamedThing pleural disease A thoracic disease which may involve inflammation of pleura, collection of air within the pleural cavity, abnormal collection of pleural fluid, abnormal growths on the pleura (pleural tumor) and pleural plaques. The main causes of pleural diseases including pleural effusions are congestive heart failure, malignancy, parapneumonic infections and pulmonary embolism. RBO_relaxed.owl DOID:850 biolink:NamedThing lung disease A lower respiratory tract disease in which the function of the lungs is adversely affected by narrowing or blockage of the airways resulting in poor air flow, a loss of elasticity in the lungs that produces a decrease in the total volume of air that the lungs are able to hold, and clotting, scarring, or inflammation of the blood vessels that affect the ability of the lungs to take up oxygen and to release carbon dioxide. RBO_relaxed.owl DOID:1307 biolink:NamedThing dementia A cognitive disorder resulting from a loss of brain function affecting memory, thinking, language, judgement and behavior. RBO_relaxed.owl DOID:2030 biolink:NamedThing anxiety disorder A cognitive disorder that involves an excessive, irrational dread of everyday situations. RBO_relaxed.owl DOID:2468 biolink:NamedThing psychotic disorder A cognitive disorder that involves abnormal thinking and perceptions resulting in a disconnection with reality. RBO_relaxed.owl DOID:630 biolink:NamedThing genetic disease A disease that has_material_basis_in genetic variations in the human genome. RBO_relaxed.owl DOID:1936 biolink:NamedThing atherosclerosis RBO_relaxed.owl DOID:3393 biolink:NamedThing coronary artery disease An artery disease that is characterized by plaque building up along the inner walls of the arteries of the heart resulting in a narrowing of the arteries and a reduced blood supply to the cardiac muscles. RBO_relaxed.owl DOID:2513 biolink:NamedThing basal cell carcinoma A skin carcinoma affecting basal cells. RBO_relaxed.owl DOID:3083 biolink:NamedThing chronic obstructive pulmonary disease An obstructive lung disease that is characterized by irreversible airflow obstruction due to chronic bronchitis, emphysema, and/or small airways disease. RBO_relaxed.owl DOID:657 biolink:NamedThing adenoma A cell type benign neoplasm that is composed_of epithelial tissue in which tumor cells form glands or glandlike structures. RBO_relaxed.owl DOID:8552 biolink:NamedThing chronic myeloid leukemia A myeloid leukemia that is characterized by over production of white blood cells. RBO_relaxed.owl DOID:9119 biolink:NamedThing acute myeloid leukemia A myeloid leukemia that is characterized by the rapid growth of abnormal white blood cells that accumulate in the bone marrow and interfere with the production of normal blood cells. RBO_relaxed.owl DOID:8719 biolink:NamedThing in situ carcinoma A carcinoma that is an early development defined by the absence of invasion of surrounding tissues. RBO_relaxed.owl DOID:8761 biolink:NamedThing acute megakaryocytic leukemia An acute myeloid leukemia that derives from blood-forming tissue in which megakaryocytes proliferate in the bone marrow and circulate in the blood in large numbers. RBO_relaxed.owl DOID:9637 biolink:NamedThing stomatitis A mouth disease that is characterized by inflammation of the mouth and lips. RBO_relaxed.owl ENVO:00000000 biolink:NamedThing geographic feature An astrononmical body part which delimited by physical discontinuities with its surroundings. RBO_relaxed.owl ENVO:01000813 biolink:NamedThing astronomical body part A material part of an astronomical body. RBO_relaxed.owl ENVO:00000191 biolink:NamedThing solid astronomical body part A part of an astronomical body which is primarily composed of a continuous volume of solid material, shaped by one or more environmental processes. RBO_relaxed.owl ENVO:01000352 biolink:NamedThing field An unbroken expanse (as of ice) RBO_relaxed.owl ENVO:01000983 biolink:NamedThing technosphere A part of an astronomical body which includes, as parts, all the entities which have been constructed or manufactured by humans or their technology and which are within the gravitational sphere of influence of that body. RBO_relaxed.owl ENVO:01001479 biolink:NamedThing fluid astronomical body part A part of an astronomical body which is primarily composed of a continuous volume of liquid or gaseous material, shaped by one or more environmental processes. RBO_relaxed.owl ENVO:01001784 biolink:NamedThing compound astronomical body part A part of an astronomical body which is composed of a continuous medium bearing liquid, gaseous, and solid material in variable quantities. RBO_relaxed.owl ENVO:03000143 biolink:NamedThing cryosphere An astronomical body part which is composed primarily of environmental materials in their frozen form. RBO_relaxed.owl ENVO:00000002 biolink:NamedThing anthropogenic geographic feature An anthropogenic geographic feature is a geographic feature resulting from the influence of human beings on nature. RBO_relaxed.owl ENVO:00000012 biolink:NamedThing hydrographic feature A geographical feature associated with water. RBO_relaxed.owl ENVO:00000003 biolink:NamedThing mine tailing Mine tailings are the materials left over after the process of separating the valuable fraction from the uneconomic fraction (gangue) of an ore. RBO_relaxed.owl ENVO:0010001 biolink:NamedThing anthropogenic environmental material Anthropogenic material in or on which organisms may live. RBO_relaxed.owl ENVO:01000458 biolink:NamedThing concrete Concrete is a composite material composed of an aggregate bonded together with a fluid cement which hardens over time. RBO_relaxed.owl ENVO:01000462 biolink:NamedThing masonry cement Masonry cement is a substance used in construction that has the disposition to set and harden and thus may be used to bind materials together. RBO_relaxed.owl ENVO:01000474 biolink:NamedThing brick material A portion of brick material is a material derived from a brick which is composed of kneaded clay-bearing soil, expanded clay aggregate, sand and lime, or concrete that has been fire-hardened or air-dried. RBO_relaxed.owl ENVO:00000010 biolink:NamedThing transport feature A construction which enables the movement of humans, their animals or their vehicles. RBO_relaxed.owl ENVO:00000073 biolink:NamedThing building A permanent walled and roofed construction. RBO_relaxed.owl ENVO:00000076 biolink:NamedThing mine An excavation in the Earth for the purpose of extracting earth materials. RBO_relaxed.owl ENVO:00000469 biolink:NamedThing research facility A facility, permanent or temporary, on land, in air, space or water, where scientific research or measurements can be undertaken. RBO_relaxed.owl ENVO:01000420 biolink:NamedThing building part A building part is a construction which is part of a building. RBO_relaxed.owl ENVO:01000779 biolink:NamedThing public infrastructure The system of public works in a country, state or region, including roads, utility lines and public buildings. RBO_relaxed.owl ENVO:02000133 biolink:NamedThing nuclear reactor A human construction which is used to initiate and control a fission nuclear chain reaction or nuclear fusion reactions. RBO_relaxed.owl ENVO:03501134 biolink:NamedThing healthcare facility A human construction in which healthcare is provided. RBO_relaxed.owl ENVO:03600014 biolink:NamedThing pipeline network A human construction which is used to transport a material which is primarily composed of liquid or gas through a system of pipes. RBO_relaxed.owl ENVO:03600021 biolink:NamedThing tailings pond A human construction which is used as a storage area for mining tailings. RBO_relaxed.owl ENVO:00000015 biolink:NamedThing ocean A marine water body which is constitutes the majority of an astronomical body's hydrosphere. RBO_relaxed.owl ENVO:00001999 biolink:NamedThing marine water body A significant accumulation of water which is part of a marine biome. RBO_relaxed.owl ENVO:00000016 biolink:NamedThing sea A large expanse of saline water usually connected with an ocean. RBO_relaxed.owl ENVO:01001319 biolink:NamedThing saline water body A body of water which is primarily composed of saline water. RBO_relaxed.owl ENVO:00000019 biolink:NamedThing saline lake A lake whose water contains a considerable concentration of dissolved salts. RBO_relaxed.owl ENVO:00000017 biolink:NamedThing saline hydrographic feature A geographical feature associated with water with a halinity above 30 ppt (roughly 35 g/L). RBO_relaxed.owl ENVO:00000020 biolink:NamedThing lake A body of water or other liquid of considerable size contained in a depression on a landmass. RBO_relaxed.owl ENVO:01000680 biolink:NamedThing polluted lake A lake which has concentrations of environmental contaminants high enough to harm the ecosystems associated with it. RBO_relaxed.owl ENVO:01001022 biolink:NamedThing natural lake A lake which has formed as the result of processes that are not or are only minimally driven by human activity. RBO_relaxed.owl ENVO:01000617 biolink:NamedThing lentic water body A lentic water body is a water body in which the accumulated water, in its totality, has very little to no directed flow. RBO_relaxed.owl ENVO:00000028 biolink:NamedThing sand pit quarry A quarry from which sand is extracted. RBO_relaxed.owl ENVO:00000284 biolink:NamedThing quarry An open-pit mine from which rock or minerals are extracted. RBO_relaxed.owl ENVO:00000043 biolink:NamedThing wetland area An vegetated area which overlaps a wetland ecosystem. RBO_relaxed.owl ENVO:01001305 biolink:NamedThing vegetated area A vegetated area is a geographic feature which has ground cover dominated by plant communities. RBO_relaxed.owl ENVO:00000106 biolink:NamedThing grassland area An area in which grasses (Graminae) are a significant component of the vegetation. RBO_relaxed.owl ENVO:00000109 biolink:NamedThing woodland area Land having a cover of trees, shrubs, or both. RBO_relaxed.owl ENVO:00000300 biolink:NamedThing scrubland area Area covered with low-growing or stunted perennial vegetation and usually not mixed with trees. RBO_relaxed.owl ENVO:01000887 biolink:NamedThing area of sedge- and forb-dominated herbaceous vegetation An area of a planet's surface which is primarily covered by sedges or forbs, possibly interpersed with grasses or grass-like plants. This area is in contact with an atmospheric column extending from the planetary boundary layer to the planet's exosphere with little to no physical obstruction. RBO_relaxed.owl ENVO:01001293 biolink:NamedThing bush area A vegetated area which has not been cleared or is sparsely settled, usually scrub-covered or forested RBO_relaxed.owl ENVO:00000063 biolink:NamedThing water body An accumulation of water of varying size. RBO_relaxed.owl ENVO:01000685 biolink:NamedThing water mass A mass of water. RBO_relaxed.owl ENVO:00005803 biolink:NamedThing animal habitation The dwelling of an animal or group of similar animals. RBO_relaxed.owl ENVO:00000097 biolink:NamedThing desert area A region rendered barren or partially barren by environmental extremes, especially by low rainfall. RBO_relaxed.owl ENVO:01000752 biolink:NamedThing area of barren land An area of a planet's surface which is primarily composed of bedrock, desert pavement, scarp rock, talus, material exposed by slides, volcanic material, glacial debris, sand, material exposed during strip mining, gravel, and other accumulations of earthen material in contact with an atmospheric column extending from the planetary boundary layer to the planet's exosphere with little to no physical obstruction. RBO_relaxed.owl ENVO:00000100 biolink:NamedThing valley A depression which has been formed as a result of erosion by water or ice and which is low-lying, bordered by higher ground, and especially elongate. RBO_relaxed.owl ENVO:03000015 biolink:NamedThing geographic basin A depression which is part of a planetary crust, is of geographic scale, and is partially or completely enclosed. RBO_relaxed.owl ENVO:00000111 biolink:NamedThing forested area An area with a high density of trees. A small forest may be called a wood. RBO_relaxed.owl ENVO:00000128 biolink:NamedThing dry valley A valley which no longer has water flowing or accumulating over its surface. RBO_relaxed.owl ENVO:00000248 biolink:NamedThing glacial valley A valley that contains, or contained, a glacier and was formed by glacial activity. Typically U-shaped in cross-section. RBO_relaxed.owl ENVO:00000134 biolink:NamedThing permafrost An environmental material which is 1) composed primarily of soil or rock and included ice or organic material and 2) at or below the freezing point of water for two or more years. RBO_relaxed.owl ENVO:00010483 biolink:NamedThing environmental material A portion of environmental material is a fiat object part which forms the medium or part of the medium of an environmental system. RBO_relaxed.owl ENVO:00000194 biolink:NamedThing scree Broken rock that appears at the bottom of crags, mountain cliffs or valley shoulders. RBO_relaxed.owl ENVO:00001998 biolink:NamedThing soil An environmental material which is primarily composed of minerals, varying proportions of sand, silt, and clay, organic material such as humus, interstitial gases, liquids, and a broad range of resident micro- and macroorganisms. RBO_relaxed.owl ENVO:00002007 biolink:NamedThing sediment Sediment is an environmental substance comprised of any particulate matter that can be transported by fluid flow and which eventually is deposited as a layer of solid particles on the bedor bottom of a body of water or other liquid. RBO_relaxed.owl ENVO:00002264 biolink:NamedThing waste material A material which is not the desired output of a process and which is typically the input of a process which removes it from its producer (e.g. a disposal process). RBO_relaxed.owl ENVO:00010505 biolink:NamedThing aerosol Airborne solid particles (also called dust or particulate matter (PM)) or liquid droplets. RBO_relaxed.owl ENVO:01000060 biolink:NamedThing particulate environmental material An environmental material which is composed primarily of particles. RBO_relaxed.owl ENVO:01000155 biolink:NamedThing organic material Environmental material derived from living organisms and composed primarily of one or more biomacromolecules. RBO_relaxed.owl ENVO:01000256 biolink:NamedThing mineral material A mineral material is an environmental material which is primarily composed of some substance that is naturally occurring, solid and stable at room temperature, representable by a chemical formula, usually abiogenic, and that has an ordered atomic structure. RBO_relaxed.owl ENVO:01000406 biolink:NamedThing snow Snow is an environmental material which is primarily composed of flakes of crystalline water ice. RBO_relaxed.owl ENVO:01000637 biolink:NamedThing outer space Outer space is a hard vacuum containing a low density of particles, predominantly a plasma of hydrogen and helium as well as electromagnetic radiation, magnetic fields, neutrinos, dust and cosmic rays that exists between celestial bodies. RBO_relaxed.owl ENVO:01000797 biolink:NamedThing gaseous environmental material A material entity which is composed of one or more chemical entities and has neither independent shape nor volume but tends to expand indefinitely. RBO_relaxed.owl ENVO:01000814 biolink:NamedThing solid environmental material An environmental material which is in a solid state. RBO_relaxed.owl ENVO:01000815 biolink:NamedThing liquid environmental material An environmental material which is in a liquid state. RBO_relaxed.owl ENVO:01001069 biolink:NamedThing metallic material A material which is composed primarily of one or more pure metals and which shows their properties. RBO_relaxed.owl ENVO:01001125 biolink:NamedThing ice An ice is an environmental material which is either frozen or which is maintained in a solid state by gravitational forces or pressure. RBO_relaxed.owl ENVO:01001154 biolink:NamedThing volatile astrogeological material A material which is composed primarily of chemical elements and compounds with relatively low boiling points, equilibrium condensation temperatures below 1300 Kelvin, and which are part of the crust or atmosphere of a moon or planet. RBO_relaxed.owl ENVO:02000140 biolink:NamedThing fluid environmental material A liquid or a gas. RBO_relaxed.owl ENVO:03510037 biolink:NamedThing radioactive material Any material containing unstable atoms that emit ionizing radiation as it decays. RBO_relaxed.owl ENVO:00000147 biolink:NamedThing ocean current The region occupied by any more or less continuous, directed movement of ocean water that flows in one of the Earth's oceans. Ocean Currents are rivers of hot or cold water within the ocean. The currents are generated from the forces acting upon the water like the earth's rotation, the wind, the temperature and salinity differences and the gravitation of the moon. The depth contours, the shoreline and other movements influence the direction and strength of the movements of water that forms a given current. RBO_relaxed.owl ENVO:01000067 biolink:NamedThing marine current A water current which is maintained by a continuous, directed movement of marine water, generated by forces caused by breaking waves, wind, Coriolis force, temperature and salinity differences, and tides caused by the gravitational pull of astronomical bodies. Depth contours, shoreline configurations and interaction with other currents influence a current's direction and strength. RBO_relaxed.owl ENVO:00000176 biolink:NamedThing elevated landform A landform elevated above the surrounding area. RBO_relaxed.owl ENVO:01001886 biolink:NamedThing landform A solid astronomical body part which has been formed from and is composed primarily of the matter of that astronomical body. RBO_relaxed.owl ENVO:00000309 biolink:NamedThing depressed landform A landform sunken or depressed below the surrounding area. RBO_relaxed.owl ENVO:00002000 biolink:NamedThing slope A solid astronomical body part which is part of the planetary surface between the peak of an elevation or the bottom of a depression and relatively flat surrounding land. RBO_relaxed.owl ENVO:01001884 biolink:NamedThing surface landform A landform which occurs on the surface of an astronomical body. RBO_relaxed.owl ENVO:01000687 biolink:NamedThing coast A coast is the area where land meets the sea, ocean, or lake. RBO_relaxed.owl ENVO:01000817 biolink:NamedThing biosphere A biosphere is a part of an astronomical body which includes, as parts, all the living entities within the gravitational sphere of influence of that body, as well as the non-living and dead entities with which they interact. RBO_relaxed.owl ENVO:01000820 biolink:NamedThing pedosphere An astronomical body part which is composed of soil, subject to soil formation processes, and found on the surface of a lithosphere. RBO_relaxed.owl ENVO:01001477 biolink:NamedThing liquid astronomical body part A part of an astronomical body which is primarily composed of a continuous volume of liquid material, shaped by one or more environmental processes. RBO_relaxed.owl ENVO:01001478 biolink:NamedThing gaseous astronomical body part A part of an astronomical body which is primarily composed of a continuous volume of gaseous material, shaped by one or more environmental processes. RBO_relaxed.owl ENVO:00000233 biolink:NamedThing swamp ecosystem A wetland ecosystem in which land mass is permanently inundated by shallow bodies of water, generally with a substantial number of hummocks, or dry-land protrusions. RBO_relaxed.owl ENVO:01001209 biolink:NamedThing wetland ecosystem A terrestrial ecosystem which is inundated or saturated by surface or ground water at a frequency and duration sufficient to support, and that under normal circumstances does support, a prevalence of vegetation typically adapted for life in saturated soil conditions. RBO_relaxed.owl ENVO:02000110 biolink:NamedThing open-pit mine A surface mine that utilizes a technique of extracting rock or minerals from the earth by their removal from an open pit or borrow. RBO_relaxed.owl ENVO:00000299 biolink:NamedThing ice field A field of ice, formed in regions of perennial frost. RBO_relaxed.owl ENVO:03000110 biolink:NamedThing cryoform A solid astronomical body part which is primarily composed of a continuous mass of snow and/or ice. RBO_relaxed.owl ENVO:00000339 biolink:NamedThing piece of rock A mass of solid material which is composed primarily of rock. RBO_relaxed.owl ENVO:01001687 biolink:NamedThing mass of solid material An mass of environmental material which is composed primarily of a solid environmental material RBO_relaxed.owl ENVO:01000293 biolink:NamedThing ice mass A mass of water ice. RBO_relaxed.owl ENVO:01003002 biolink:NamedThing particle A mass of solid material which is either 1) a minute fragment of a larger mass or 2) one of a collection of small masses composing an aggregate. RBO_relaxed.owl ENVO:00000340 biolink:NamedThing particle of sand A particle which 1) is composed primarily of and derived from rock or mineral sources and 2) is or was part of a portion of sand. RBO_relaxed.owl ENVO:00000343 biolink:NamedThing particle of silt A particle which 1) is primarily composed of quartz or feldspar and 2) is or was part of a portion of silt. RBO_relaxed.owl ENVO:01003003 biolink:NamedThing particle of clay A particle which 1) is composed primarily of hydrous aluminium phyllosilicate minerals, in turn composed of aluminium and silicon ions bonded into tiny, thin plates by interconnecting oxygen and hydroxide ions, and 2) is or was part of a portion of clay. RBO_relaxed.owl ENVO:00000344 biolink:NamedThing grain of desert sand RBO_relaxed.owl ENVO:00000428 biolink:NamedThing biome A biome is an ecosystem to which resident ecological communities have evolved adaptations. RBO_relaxed.owl ENVO:01001110 biolink:NamedThing ecosystem An environmental system which includes both living and non-living components. RBO_relaxed.owl ENVO:01000276 biolink:NamedThing ecoregion A large unit of land or water containing a geographically distinct assemblage of species, natural communities, and environmental conditions. RBO_relaxed.owl ENVO:01000280 biolink:NamedThing ecozone Ecozones delineate large areas of a planetary surface within which organisms have been evolving in relative isolation over long periods of time, separated from one another by geographic features, such as oceans, broad deserts, or high mountain ranges, that constitute barriers to migration. RBO_relaxed.owl ENVO:01000739 biolink:NamedThing habitat An environmental system which can sustain and allow the growth of an ecological population. RBO_relaxed.owl ENVO:01001000 biolink:NamedThing environmental system determined by an organism An environmental system which is determined by a living organism. RBO_relaxed.owl ENVO:01001055 biolink:NamedThing environment associated with an animal part or small animal An environmental system determined by part of a living or dead animal, or a whole small animal. RBO_relaxed.owl ENVO:01001057 biolink:NamedThing environment associated with a plant part or small plant An environmental system determined by part of a living or dead plant, or a whole small plant. RBO_relaxed.owl ENVO:01001167 biolink:NamedThing ecosystem fragment An ecosystem which has been causally isolated from a larger ecosystem within which it was previously embedded, such that the direct exchange of materials, resources, and energy between these systems is severely or entirely curtailed. RBO_relaxed.owl ENVO:01001780 biolink:NamedThing desert ecosystem An ecosystem in which the composition, structure, and function of resident ecological assemblages are primarily determined by a desert. RBO_relaxed.owl ENVO:01001787 biolink:NamedThing aquatic ecosystem RBO_relaxed.owl ENVO:01001790 biolink:NamedThing terrestrial ecosystem RBO_relaxed.owl ENVO:00000446 biolink:NamedThing terrestrial biome A biome which is primarily or completely situated on a landmass. RBO_relaxed.owl ENVO:00002030 biolink:NamedThing aquatic biome A biome which is determined by a water body and which has ecological climax communities adapted to life in or on water. RBO_relaxed.owl ENVO:01000339 biolink:NamedThing polar biome A biome which is subject to polar climatic conditions. RBO_relaxed.owl ENVO:01001830 biolink:NamedThing tropical biome A biome which is subject to tropical climatic conditions. RBO_relaxed.owl ENVO:01001831 biolink:NamedThing temperate biome A biome which is subject to temperate climatic conditions. RBO_relaxed.owl ENVO:01001832 biolink:NamedThing subtropical biome A biome which is subject to subtropical climatic conditions. RBO_relaxed.owl ENVO:01001834 biolink:NamedThing subpolar biome A biome which is subject to subpolar climatic conditions. RBO_relaxed.owl ENVO:01001835 biolink:NamedThing alpine biome A biome which is subject to alpine altitudinal conditions. RBO_relaxed.owl ENVO:01001836 biolink:NamedThing montane biome A biome which is subject to montane altitudinal conditions. RBO_relaxed.owl ENVO:01001838 biolink:NamedThing arid biome A biome which is subject to arid environmental conditions. RBO_relaxed.owl ENVO:00000447 biolink:NamedThing marine biome An aquatic biome which is determined by a marine water body. RBO_relaxed.owl ENVO:01001788 biolink:NamedThing marine ecosystem RBO_relaxed.owl ENVO:00000501 biolink:NamedThing submerged bed The portion of the ground surface which lies below water. RBO_relaxed.owl ENVO:01001311 biolink:NamedThing solid surface layer A surface layer which is composed primarily of solid environmental material. RBO_relaxed.owl ENVO:01001785 biolink:NamedThing land A surface layer of an astronomical body which is primarily composed of solid material and is not covered by oceans or other bodies of water. RBO_relaxed.owl ENVO:04000010 biolink:NamedThing soil surface layer A surface layer which is composed primarily of soil. RBO_relaxed.owl ENVO:01001483 biolink:NamedThing surface of an astronomical body A surface layer where the solid or liquid material of an astronomical body comes into contact with an atmosphere or outer space. RBO_relaxed.owl ENVO:01000324 biolink:NamedThing planetary surface A planetary surface is a surface layer where the solid or liquid material of a planet comes into contact with an atmosphere or outer space. RBO_relaxed.owl ENVO:01001554 biolink:NamedThing surface layer of a water body A water surface that is part of a water body. RBO_relaxed.owl ENVO:00001995 biolink:NamedThing rock A rock is a naturally occurring solid aggregate of one or more minerals or mineraloids. RBO_relaxed.owl ENVO:00002008 biolink:NamedThing dust Particulate environmental material with diameters less than 500 micrometers. RBO_relaxed.owl ENVO:00002040 biolink:NamedThing wood RBO_relaxed.owl ENVO:01000277 biolink:NamedThing water ice Ice which is formed from water. RBO_relaxed.owl ENVO:01000845 biolink:NamedThing crystal A solid material whose constituents, such as atoms, molecules or ions, are arranged in a highly ordered microscopic structure, forming a crystal lattice that extends in all directions. RBO_relaxed.owl ENVO:01001121 biolink:NamedThing plant matter Organic material which is primarily composed of plant structures, living or dead. RBO_relaxed.owl ENVO:01001646 biolink:NamedThing amorphous solid A solid material which does not have a regularly organised internal structure. RBO_relaxed.owl ENVO:01001308 biolink:NamedThing hydroform A liquid astronomical body part which is primarily composed of a continuous volume of liquid water and is held in shape or sustained by an environmental process. RBO_relaxed.owl ENVO:01001607 biolink:NamedThing water current A hydroform which is maintained by a continuous, directed movement of water, generated by disequilibria in a water mass. RBO_relaxed.owl ENVO:00002005 biolink:NamedThing air The mixture of gases (roughly (by molar content/volume: 78% nitrogen, 20.95% oxygen, 0.93% argon, 0.038% carbon dioxide, trace amounts of other gases, and a variable amount (average around 1%) of water vapor) that surrounds the planet Earth. RBO_relaxed.owl ENVO:01000266 biolink:NamedThing water vapour Water vapour is a vapour which is the gas phase of water. RBO_relaxed.owl ENVO:00002006 biolink:NamedThing liquid water An environmental material primarily composed of dihydrogen oxide in its liquid form. RBO_relaxed.owl ENVO:00002982 biolink:NamedThing clay Particulate environmental material which 1) is composed primarily of clay particles, with only minor proportions of other materials, 2) demonstrates plasticity when wet, and 3) is capable of hardening when dried or fired. RBO_relaxed.owl ENVO:01000016 biolink:NamedThing silt Particulate environmental material which is primarily composed of silt particles. RBO_relaxed.owl ENVO:01000017 biolink:NamedThing sand Particulate environmental material which is composed primarily of particles of sand with only minor proportions of other substances. RBO_relaxed.owl ENVO:03000021 biolink:NamedThing soot Particulate environmental material which is composed primarily of carbon particles formed through the incomplete combustion of hydrocarbons. RBO_relaxed.owl ENVO:00002010 biolink:NamedThing saline water Water which contains a significant concentration of dissolved salts. RBO_relaxed.owl ENVO:00002186 biolink:NamedThing contaminated water RBO_relaxed.owl ENVO:01000358 biolink:NamedThing acidic water A portion of acidic water is a portion of water with a pH less than 7. RBO_relaxed.owl ENVO:00002016 biolink:NamedThing sedimentary rock A rock formed by deposition of either clastic sediments, organic matter, or chemical precipitates (evaporites), followed by compaction of the particulate matter and cementation during diagenesis. RBO_relaxed.owl ENVO:02000094 biolink:NamedThing ore a type of rock that contains sufficient minerals with important elements including metals that can be economically extracted from the rock. RBO_relaxed.owl ENVO:01000063 biolink:NamedThing planktonic material A portion of planktonic material is a portion of environmental material primarily composed of plankton. RBO_relaxed.owl ENVO:01000349 biolink:NamedThing root matter An organic material primarily composed of a portion of plant root. RBO_relaxed.owl ENVO:01001189 biolink:NamedThing algal material RBO_relaxed.owl ENVO:01001391 biolink:NamedThing gill tissue material RBO_relaxed.owl ENVO:04000008 biolink:NamedThing soil organic matter Organic material in soil, which consists of plant and animal residues at various stages of decomposition, cells and tissues of soil organisms, and substances synthesized by soil organisms. RBO_relaxed.owl ENVO:00002114 biolink:NamedThing chemically enriched sediment Sediment which has increased levels of one or more chemical compounds. RBO_relaxed.owl ENVO:03000033 biolink:NamedThing marine sediment Sediment which has been transported through the marine water column, settling on the seafloor. RBO_relaxed.owl ENVO:03600001 biolink:NamedThing chemically contaminated sediment Sediment which contains some chemical contaminant. RBO_relaxed.owl ENVO:00002116 biolink:NamedThing contaminated soil A portion of contaminated soil is a portion of soil with elevated levels of some contaminant. RBO_relaxed.owl ENVO:00003082 biolink:NamedThing enriched soil A portion of enriched soil is a portion of soil with elevated levels of some material entity. RBO_relaxed.owl ENVO:00002149 biolink:NamedThing sea water Water which has physicochemical properties that have been determined by the processes occuring in a sea or ocean. RBO_relaxed.owl ENVO:00002167 biolink:NamedThing platinum mine RBO_relaxed.owl ENVO:00002168 biolink:NamedThing gold mine RBO_relaxed.owl ENVO:00002169 biolink:NamedThing coal mine RBO_relaxed.owl ENVO:02000092 biolink:NamedThing iron mine RBO_relaxed.owl ENVO:02000093 biolink:NamedThing uranium mine RBO_relaxed.owl ENVO:00002173 biolink:NamedThing hospital A hospital is a building in which health care services are provided by specialized staff and equipment. RBO_relaxed.owl ENVO:00002202 biolink:NamedThing organically enriched sediment Chemically-enriched sediment which has increased levels of organic compounds. RBO_relaxed.owl ENVO:00002203 biolink:NamedThing inorganically enriched sediment Chemically-enriched sediment which has increased levels of inorganic compounds. RBO_relaxed.owl ENVO:00002206 biolink:NamedThing coal mine waste material RBO_relaxed.owl ENVO:00002267 biolink:NamedThing industrial waste material Industrial wastes are liquid, solid and gaseous wastes originating from the manufacture of specific products. RBO_relaxed.owl ENVO:00002214 biolink:NamedThing power plant A power plant is a building which contains one or more generators which convert mechanical energy into electrical energy through the relative motion between a magnetic field and a conductor. The energy source harnessed to turn the generator varies widely. RBO_relaxed.owl ENVO:00003861 biolink:NamedThing industrial building An industrial building is a building within which goods are produced and, optionally, stored or within which services are rendered. RBO_relaxed.owl ENVO:00003885 biolink:NamedThing brewery A brewery is a building in which alcoholic beverages are produced by brewing, that is, steeping a starch source (commonly cereal grains) in water and fermenting the resulting sweet liquid with yeast. At times, the products are also sold from the brewery. RBO_relaxed.owl ENVO:01000536 biolink:NamedThing factory A factory (previously manufactory) or manufacturing plant is an industrial site, usually consisting of buildings and machinery, or more commonly a complex having several buildings, where workers manufacture goods or operate machines processing one product into another. RBO_relaxed.owl ENVO:00002215 biolink:NamedThing geothermal power plant A geothermal power plant is a power plant which uses heat generated by the decay of radioactive isotopes in the Earth's mantle and crust as well as primordial heat left over from the formation of the Earth to drive its generators. RBO_relaxed.owl ENVO:00002271 biolink:NamedThing nuclear power plant A nuclear power plant is a power plant which uses heat generated by a radioactive decay in a nuclear reactor to convert water into steam in order to drive turbines in electrical generators through pressure. RBO_relaxed.owl ENVO:2000037 biolink:NamedThing fossil fuel power plant A power station which burns a fossil fuel such as coal, natural gas, or petroleum to produce electricity. RBO_relaxed.owl ENVO:2000038 biolink:NamedThing coal power plant RBO_relaxed.owl ENVO:2000041 biolink:NamedThing solar power station RBO_relaxed.owl ENVO:2000042 biolink:NamedThing ocean thermal power station RBO_relaxed.owl ENVO:2000043 biolink:NamedThing tidal power plant RBO_relaxed.owl ENVO:00002261 biolink:NamedThing forest soil A portion of soil which is found in a forested area. RBO_relaxed.owl ENVO:00005748 biolink:NamedThing dry soil Soil which has little to no water content and in which minerals and other soluble chemical entities have either bonded or become adsorbed to sold particles due to insufficient water availability. RBO_relaxed.owl ENVO:00005750 biolink:NamedThing grassland soil A portion of soil which is found in a grassland. RBO_relaxed.owl ENVO:00005786 biolink:NamedThing upland soil Soil which is part of some elevated land. RBO_relaxed.owl ENVO:01001185 biolink:NamedThing acidic soil Soil which has increased levels of molecules or ions capable of donating a hydron (proton or hydrogen ion) to other chemical entities, or, alternatively, capable of forming covalent bonds with other chemicals via the acceptance of an electron pair, resulting in a bulk pH measurement of less than 7. RBO_relaxed.owl ENVO:01001526 biolink:NamedThing frozen soil Soil which is below the freezing point of water. RBO_relaxed.owl ENVO:00002874 biolink:NamedThing air conditioning unit A manufactuered product which is capable of removing heat and controlling the humidity of the air within a site. RBO_relaxed.owl ENVO:00003968 biolink:NamedThing air filter An air filter is a device that removes some substance from air. RBO_relaxed.owl ENVO:01000457 biolink:NamedThing masonry unit A masonry unit is a solid piece of material, usually with a regular shape, used as a component in the construction of buildings. Masonry units are usually composed of brick, stone, marble, granite, travertine, limestone, cast stone, concrete block, glass block, stucco, tile, or cob. RBO_relaxed.owl ENVO:01000507 biolink:NamedThing iron sheet An iron sheet is a mass of iron which has been forged into a roughly planar form of less than 6 millimetres in thickness. RBO_relaxed.owl ENVO:01000514 biolink:NamedThing tile A tile is a manufactured piece of hard-wearing material such as ceramic, stone, metal, or even glass, generally used for covering roofs, floors, walls, showers, or other objects such as tabletops. Alternatively, tile can sometimes refer to similar units made from lightweight materials such as perlite, wood, and mineral wool, typically used for wall and ceiling applications. RBO_relaxed.owl ENVO:01000604 biolink:NamedThing vehicle A vehicle is a mobile machine which transports people or cargo. RBO_relaxed.owl ENVO:01000610 biolink:NamedThing motor A motor is a machine designed to convert one or more forms of energy into mechanical energy. RBO_relaxed.owl ENVO:01000975 biolink:NamedThing animal trap A manufactured product which is designed to catch and hold animals. RBO_relaxed.owl ENVO:01000989 biolink:NamedThing plumbing fixture An exchangeable device which can be connected to a plumbing system to deliver and drain water. RBO_relaxed.owl ENVO:00003040 biolink:NamedThing animal house A house used for sheltering non-human animals. RBO_relaxed.owl ENVO:01000417 biolink:NamedThing house A house is a building that provides a dwelling-place for a living entity. RBO_relaxed.owl ENVO:01000418 biolink:NamedThing human house RBO_relaxed.owl ENVO:01000781 biolink:NamedThing public building A building which is publically accessible. RBO_relaxed.owl ENVO:01001222 biolink:NamedThing commercial building A building which is primarily used to facilitate the buying or selling of goods or services. RBO_relaxed.owl ENVO:01001480 biolink:NamedThing domestic building A building which is primarily used for the long-term habitation of humans. RBO_relaxed.owl ENVO:00003919 biolink:NamedThing research station A building or collection of co-located buildings constructed for the purpose of undertaking scientific research. RBO_relaxed.owl ENVO:01001406 biolink:NamedThing laboratory facility A research facility in which systems of manufactured products control internal conditions and in which scientific or technological research, experiments, and measurement may be performed. RBO_relaxed.owl ENVO:00003963 biolink:NamedThing warehouse A warehouse is a building which is used for the storage of goods. RBO_relaxed.owl ENVO:01001221 biolink:NamedThing office building A commercial building which contains parts used as workplaces primarily for administrative and managerial workers. RBO_relaxed.owl ENVO:00005800 biolink:NamedThing desert sand Sand which is part of a desert. RBO_relaxed.owl ENVO:00005805 biolink:NamedThing nest of bird A bird nest is the spot in which a bird lays and incubates its eggs and raises its young. RBO_relaxed.owl ENVO:00010504 biolink:NamedThing surface layer A layer of some material entity which is adjacent to one or more of its external boundaries and directly interacts with its immediate surroundings. RBO_relaxed.owl ENVO:01001684 biolink:NamedThing interface layer A layer which separates two portions of environmental material which possess 1) differing compositions, 2) a discontinuity of some property, or 3) some derivative of some property in a direction normal to the interface. RBO_relaxed.owl ENVO:01001677 biolink:NamedThing fluid interface layer A surface layer which separates two portions of fluid with respect to either 1) a discontinuity of some fluid property or 2) some derivative of one of these properties in a direction normal to the interface. RBO_relaxed.owl ENVO:01000005 biolink:NamedThing upwelling MERGED DEFINITION: TARGET DEFINITION: An oceanographic feature that involves wind-driven motion of dense, cooler, and usually nutrient-rich water towards the ocean surface, replacing the warmer, usually nutrient-deplete surface water. -------------------- SOURCE DEFINITION: A marine upwelling is a net flow of marine water to the surface of the water column from deeper regions. This is often a result of surface water displacement off continental coasts by wind action. Localised upwellings may also occur along divergent fronts around eddies and along some of the major oceanographic features. Deeper waters often have higher nutrient content; consequently blooms of primary producers, such as planktonic algae, are generally observed around upwelling zones. RBO_relaxed.owl ENVO:01000020 biolink:NamedThing estuarine biome Expressions of the estuarine biome occur at wide lower courses of a rivers where they flow into a sea. Estuaries experience tidal flows and their water is a changing mixture of fresh and salt. RBO_relaxed.owl ENVO:01000022 biolink:NamedThing marine salt marsh biome The marine salt marsh biome comprises marshes that are transitional intertidals between land and salty or brackish marine water (e.g.: sloughs, bays, estuaries). It is dominated by halophytic (salt tolerant) herbaceous plants. The daily tidal surges bring in nutrients, which tend to settle in roots of the plants within the salt marsh. The natural chemical activity of salty (or brackish) water and the tendency of algae to bloom in the shallow unshaded water also allow for great biodiversity. RBO_relaxed.owl ENVO:01000046 biolink:NamedThing marginal sea biome The marginal sea biome comprises parts of an ocean partially enclosed by land such as islands, archipelagos, or peninsulas. Unlike mediterranean seas, marginal seas have ocean currents caused by ocean winds. Many marginal seas are enclosed by island arcs that were formed from the subduction of one oceanic plate beneath another. RBO_relaxed.owl ENVO:01000048 biolink:NamedThing ocean biome A marine biome which is determined by an ocean. RBO_relaxed.owl ENVO:01000858 biolink:NamedThing marine upwelling biome A marine biome which contains communities adapted to living in an environment determined by an upwelling process. RBO_relaxed.owl ENVO:01000174 biolink:NamedThing forest biome A forest ecosystem in which dominant ecological communities have reached their climax successional state. RBO_relaxed.owl ENVO:01001243 biolink:NamedThing forest ecosystem An ecosystem which is determined by communities of plants with a tree growth form and in which members of those communities form continuous or discontinuous regions of canopy cover. RBO_relaxed.owl ENVO:01000430 biolink:NamedThing broadleaf forest A forest biome which contains densely packed populations or communities of broadleaf trees, strongly limiting light penetration to the forest floor. RBO_relaxed.owl ENVO:01000431 biolink:NamedThing mixed forest A forest ecosystem which contains densely packed populations or communities of broadleaf and coniferous trees, strongly limiting light penetration to the forest floor. RBO_relaxed.owl ENVO:01000432 biolink:NamedThing swamp forest RBO_relaxed.owl ENVO:01000433 biolink:NamedThing needleleaf forest RBO_relaxed.owl ENVO:01000434 biolink:NamedThing sclerophyllous forest RBO_relaxed.owl ENVO:01000435 biolink:NamedThing montane forest RBO_relaxed.owl ENVO:01001803 biolink:NamedThing tropical forest A forest ecosystem which is subject to tropical climate conditions. RBO_relaxed.owl ENVO:01001804 biolink:NamedThing subtropical forest A forest ecosystem which is subject to subtropical climate conditions. RBO_relaxed.owl ENVO:01001805 biolink:NamedThing temperate forest A forest ecosystem which is subject to temperate climate conditions. RBO_relaxed.owl ENVO:01000175 biolink:NamedThing woodland biome A woodland biome is a terrestrial biome which includes, across its entire spatial extent, woody plants spaced sufficiently far apart to allow light penetration to support communities of herbaceous plants or shrubs living closer to the woodland floor. RBO_relaxed.owl ENVO:01000176 biolink:NamedThing shrubland biome A shrubland biome is a terrestrial biome which includes, across its entire spatial extent, dense groups of shrubs. RBO_relaxed.owl ENVO:01000219 biolink:NamedThing anthropogenic terrestrial biome An anthropogenic terrestrial biome is a terrestrial biome which has community structures determined by human activity. RBO_relaxed.owl ENVO:01000178 biolink:NamedThing savanna biome A woodland biome which has seasonal water availability and includes trees spaced sufficiently far apart to allow an unbroken layer of grass, sedge (Cyperaceae) or rush (Juncaceae) communities to live. RBO_relaxed.owl ENVO:01000221 biolink:NamedThing temperate woodland biome A woodland biome which is subject to temperate climate patterns. RBO_relaxed.owl ENVO:01000179 biolink:NamedThing desert biome A desert biome is a terrestrial biome which loses more liquid water by evapotranspiration than is supplied by precipitation and includes communities adapted to these conditions. RBO_relaxed.owl ENVO:01000184 biolink:NamedThing subtropical desert biome A subtropical desert biome is a desert biome which has communities adapted to temperatures above a monthly average of 18 degrees Celsius, high daily temperature ranges of approximately 20 degrees Celsius, high insolation (but lower than that of a tropical desert biome), inhibited cloud formation, and very low precipitation. Subtropical desert biomes located near coasts with cold upwellings may have cooler temperatures and reduced insolution due to fog. RBO_relaxed.owl ENVO:01001702 biolink:NamedThing subtropical environment An environment which has a climate with warm temperatures and with meagre precipitation. RBO_relaxed.owl ENVO:01001809 biolink:NamedThing subtropical grassland A grassland which is subject to subtropical climatic conditions. RBO_relaxed.owl ENVO:01000189 biolink:NamedThing temperate savanna biome A savanna biome which is subject to temperate climate patterns. RBO_relaxed.owl ENVO:01000215 biolink:NamedThing temperate shrubland biome A shrubland biome which is subject to temperate climate patterns. RBO_relaxed.owl ENVO:01000856 biolink:NamedThing temperate marginal sea biome A marginal sea biome which is located in a region with a temperate climate. RBO_relaxed.owl ENVO:01000860 biolink:NamedThing temperate marine upwelling biome A marine upwelling biome which is located in a region subject to temperate climate patterns. RBO_relaxed.owl ENVO:01000193 biolink:NamedThing temperate grassland biome RBO_relaxed.owl ENVO:01001705 biolink:NamedThing temperate environment An environment which is located in a part of an astronomical body subject to temperate climatic conditions. RBO_relaxed.owl ENVO:01001811 biolink:NamedThing temperate grassland RBO_relaxed.owl ENVO:01000196 biolink:NamedThing coniferous forest biome A coniferous forest biome is a forest biome which contains densely packed populations or communities of coniferous trees, strongly limiting light penetration to the forest floor. RBO_relaxed.owl ENVO:01000383 biolink:NamedThing temperate evergreen needleleaf forest An evergreen needleleaf forest which is subject to temperate climate patterns. RBO_relaxed.owl ENVO:01000386 biolink:NamedThing temperate deciduous needleleaf forest A deciduous needleleaf forest which is subject to temperate climate patterns. RBO_relaxed.owl ENVO:01000202 biolink:NamedThing temperate broadleaf forest biome A broadleaf forest which is subject to temperate climate patterns. RBO_relaxed.owl ENVO:01001794 biolink:NamedThing temperate broadleaf forest A broadleaf forest which is subject to temperate climate conditions. RBO_relaxed.owl ENVO:01000397 biolink:NamedThing temperate broadleaf evergreen forest A broadleaf evergreen forest which is subject to temperate climate patterns. RBO_relaxed.owl ENVO:01000203 biolink:NamedThing environmental condition An environmental condition is a range of a determinate quality or combination of qualities that are present in an environmental system. RBO_relaxed.owl PATO:0001018 biolink:NamedThing physical quality A quality of a physical entity that exists through action of continuants at the physical level of organisation in relation to other entities. RBO_relaxed.owl PATO:0000125 biolink:NamedThing mass A physical quality that inheres in a bearer by virtue of the proportion of the bearer's amount of matter. RBO_relaxed.owl PATO:0000140 biolink:NamedThing position A spatial quality inhering in a bearer by virtue of the bearer's spatial location relative to other objects in the vicinity. RBO_relaxed.owl PATO:0000146 biolink:NamedThing temperature A physical quality of the thermal energy of a system. RBO_relaxed.owl PATO:0000165 biolink:NamedThing time A quality in which events occur in sequence. RBO_relaxed.owl PATO:0001031 biolink:NamedThing elasticity A physical quality inhering in a bearer by virtue of the bearer's disposition to recover its size and shape after deformation in any way. RBO_relaxed.owl PATO:0001579 biolink:NamedThing contractility A physical quality that is the ability to contract or shrink. RBO_relaxed.owl PATO:0001739 biolink:NamedThing radiation quality A quality of radiation that reflects the fluence spectrum of charged and neutral particles within the material or medium where dose is being deposited. RBO_relaxed.owl PATO:0001822 biolink:NamedThing wetness A quality inhering in a bearer by virtue of whether the bearer's being covered by a liquid. RBO_relaxed.owl PATO:0002198 biolink:NamedThing quality of a substance A quality inhering in a bearer by virtue of its constitution. RBO_relaxed.owl PATO:0015021 biolink:NamedThing combustibility The propensity of a material to undergo combustion. Combustion encompasses smouldering and flaming combustion. Combustibility is usually applied to solids. RBO_relaxed.owl OBO:RBO_010017 biolink:NamedThing radiation quality Is a quality of radiation that reflects the fluence spectrum of charged and neutral particles within the material or medium where dose is being deposited. RBO_relaxed.owl OBO:RBO_010020 biolink:NamedThing tissue equivalence Denotes a substance with absorbing and scattering properties for a given radiation that sufficiently match those of a particular biological tissue. RBO_relaxed.owl ENVO:01000204 biolink:NamedThing tropical A tropical condition is an environmental condition in which an environmental system receives high yearly solar irradiance per unit area and, on Earth, the Sun reaches a subsolar point at least once during the solar year. This results in a hot and moist year-round climate at low elevations, which have a monthly average temperature above 18 degrees Celsius. RBO_relaxed.owl ENVO:01000205 biolink:NamedThing subtropical A subtropical condition is an environmental condition in which an envrionmental system receives more solar irradiance than those with temperate conditions, but less than those with tropical conditions. At low elevations, this typically results in eight months of the year having average temperatures greater than or equal to 10 degrees Celsius with the coldest monthly temperature averaging between 2 and 13 degrees Celsius. RBO_relaxed.owl ENVO:01000206 biolink:NamedThing temperate A temperate condition is an environmental condition in which an environmental system receives less solar irradiance than those with subpolar conditions, but greater than those with subtropical conditions. RBO_relaxed.owl ENVO:01000230 biolink:NamedThing arid An environmental condition in which annual precipitation is less than half of annual potential evapotranspiration. RBO_relaxed.owl ENVO:01000238 biolink:NamedThing polar A polar condition is an environmental condition in which an environmental system receives low, yearly solar irradiance per unit area, resulting in colder climatic conditions. RBO_relaxed.owl ENVO:01000251 biolink:NamedThing subpolar A subpolar condition is an environmental condition in which an environmental system receives low, yearly solar irradiance per unit area and is surrounded by large land masses. This results in very cold winters with temperatures potentially falling to around -40 degrees Celsius and summers which last no more than 3 months of the year with a 24-hour average temperature of at least 10 degrees Celsius. RBO_relaxed.owl ENVO:01000343 biolink:NamedThing altitudinal condition An altitudinal condition is an environmental condition in which ranges of factors such as temperature, humidity, soil composition, solar irradiation, and tree density vary with ranges in altitude. RBO_relaxed.owl ENVO:01000211 biolink:NamedThing temperate coniferous forest biome A coniferous forest biome which is subject to temperate climate patterns. RBO_relaxed.owl ENVO:01000250 biolink:NamedThing subpolar coniferous forest biome A coniferous forest biome which includes communities adapted to subpolar conditions. RBO_relaxed.owl ENVO:01000385 biolink:NamedThing temperate deciduous broadleaf forest A deciduous broadleaf forest which is subject to temperate climate patterns. RBO_relaxed.owl ENVO:01000395 biolink:NamedThing temperate sclerophyllous dry forest A sclerophyllous forest which is subject to temperate climate patterns. RBO_relaxed.owl ENVO:01000398 biolink:NamedThing temperate freshwater swamp forest A freshwater swamp forest which is subject to temperate climate patterns. RBO_relaxed.owl ENVO:01001796 biolink:NamedThing temperate mixed forest A mixed forest which is subject to temperate climatic conditions. RBO_relaxed.owl ENVO:01000212 biolink:NamedThing temperate mixed forest biome A temperate mixed forest in which dominant ecological communities have reached their climax successional state. RBO_relaxed.owl ENVO:01000389 biolink:NamedThing temperate mixed broadleaf forest A temperate mixed forest which has communities of trees composed primarily of species with broad leaves. RBO_relaxed.owl ENVO:01000390 biolink:NamedThing temperate mixed needleleaf forest A temperate mixed forest which has communities of trees composed primarily of species with needle-like leaves (e.g. conifers). RBO_relaxed.owl ENVO:01000216 biolink:NamedThing montane shrubland biome A montane shrubland biome is a shrubland biome which occurs in regions elevated above sea level and which has community structure determined by elevation-dependent environmental conditions. RBO_relaxed.owl ENVO:01000242 biolink:NamedThing desert scrubland A scrubland which is located in a desert. RBO_relaxed.owl ENVO:01000248 biolink:NamedThing dense settlement biome A dense settlement biome is an anthropogenic terrestrial biome which is primarily used for human habitation, recreation, and industry within built structures with little other land use. RBO_relaxed.owl ENVO:01001704 biolink:NamedThing subpolar environment An environment which is located in a part of an astronomical body subject to subpolar climatic conditions. RBO_relaxed.owl ENVO:01000254 biolink:NamedThing environmental system A system which has the disposition to environ one or more material entities. RBO_relaxed.owl ENVO:01000267 biolink:NamedThing atmosphere An atmosphere is a layer of gases surrounding a material body of sufficient mass that is held in place by the gravity of the body. RBO_relaxed.owl ENVO:01001678 biolink:NamedThing fluid layer A layer which is composed primarily of some fluid. RBO_relaxed.owl ENVO:01000543 biolink:NamedThing atmospheric layer A layer that is part of the atmosphere. RBO_relaxed.owl ENVO:01001273 biolink:NamedThing liquid layer A layer which is primarily composed of some liquid material. RBO_relaxed.owl ENVO:01000268 biolink:NamedThing atmospheric water vapour Atmospheric water vapour is water vapour that is part of an atmosphere. RBO_relaxed.owl ENVO:01001138 biolink:NamedThing carbon dioxide ice Ice which is primarily composed of carbon dioxide. RBO_relaxed.owl ENVO:01000283 biolink:NamedThing lake layer A layer which is part of a lake. RBO_relaxed.owl ENVO:01000325 biolink:NamedThing aquatic layer A layer in a water mass, itself composed primarily of water. RBO_relaxed.owl ENVO:01000295 biolink:NamedThing marine layer A layer that is part of a marine water body. RBO_relaxed.owl ENVO:01001191 biolink:NamedThing water surface The surface layer of a volume of water. RBO_relaxed.owl ENVO:01000303 biolink:NamedThing endolithic environment An endolithic environment is an environment that exists within solid rock. RBO_relaxed.owl ENVO:01000309 biolink:NamedThing cold environment An environment which has a lower temperature than some local or global average. RBO_relaxed.owl ENVO:01000313 biolink:NamedThing anthropogenic environment An anthropogenic environment is an environmental system which is the product of human activity. RBO_relaxed.owl ENVO:01000320 biolink:NamedThing marine environment A marine environment and enviroment which is determined by a marine water body. RBO_relaxed.owl ENVO:01000951 biolink:NamedThing natural environment An environmental system in which minimal to no anthropisation has occurred and non-human agents are the primary determinants of the system's dynamics and composition. RBO_relaxed.owl ENVO:01000997 biolink:NamedThing environmental system determined by a quality An environmental system which is determined by materials bearing roughly homogeneous qualities. RBO_relaxed.owl ENVO:01000998 biolink:NamedThing environmental system determined by a material An environmental system within which an environmental material strongly influences the system's composition and properties. RBO_relaxed.owl ENVO:01001701 biolink:NamedThing tropical environment An environment which has a climate with continually high temperatures and with considerable precipitation, at least during part of the year. RBO_relaxed.owl ENVO:01001703 biolink:NamedThing polar environment An environment which is located in a part of an astronomical body subject to polar climatic conditions. RBO_relaxed.owl ENVO:2100000 biolink:NamedThing anatomical entity environment An environment which is determined by an anatomical entity. RBO_relaxed.owl OBO:RBO_00000016 biolink:NamedThing radiation environment Radiation classified by where the exposure to the radiation is occurring. RBO_relaxed.owl ENVO:01000307 biolink:NamedThing saline water environment An environmental system which has its properties and dynamics determined by saline water. RBO_relaxed.owl ENVO:01000317 biolink:NamedThing aquatic environment An environment whose dynamics are strongly influenced by water. RBO_relaxed.owl ENVO:01001040 biolink:NamedThing saline environment An environment which is determined by materials which bear significant concentrations of salts. RBO_relaxed.owl ENVO:01001053 biolink:NamedThing saline aerosol environment An environmental system which has its properties and dynamics determined by a saline aerosol. RBO_relaxed.owl ENVO:01000314 biolink:NamedThing high osmolarity environment A high osmolarity environment is an environment in which entities are exposed to high concentrations of solutes. RBO_relaxed.owl ENVO:01000315 biolink:NamedThing acidic environment An acidic environment is an environment in which material entities are exposed to a low pH. RBO_relaxed.owl ENVO:01001044 biolink:NamedThing soil environment An environmental system which has its properties and dynamics determined by soil. RBO_relaxed.owl ENVO:01001048 biolink:NamedThing sediment environment An environmental system which has its properties and dynamics determined by sediment. RBO_relaxed.owl ENVO:01001052 biolink:NamedThing aerosol environment An environmental system which has its properties and dynamics determined by an aerosol. RBO_relaxed.owl ENVO:01000319 biolink:NamedThing rocky slope A rocky slope is a slope which has a surface primarily composed of rock. RBO_relaxed.owl ENVO:01000334 biolink:NamedThing talus slope A talus slope is a slope which has a surface layer composed of scree. RBO_relaxed.owl ENVO:01000321 biolink:NamedThing sea water environment An environmental system determined by seawater. RBO_relaxed.owl ENVO:01000323 biolink:NamedThing atmospheric boundary layer The atmospheric boundary layer is the lowest layer of an atmosphere which is strongly influenced by its contact with a planetary surface with strong vertical mixing and in which physical quantities such as flow velocity, temperature, and moisture display rapid fluctuations (turbulence). RBO_relaxed.owl ENVO:01000538 biolink:NamedThing stratosphere The layer of the atmosphere which is sandwiched between the troposphere and mesosphere. Of the energy that reaches the Earth from the sun, only 3% is absorbed in the stratosphere, but that includes the vitally important process of absorption of ultraviolet radiation by the stratospheric ozone layer. The stratosphere is cloudless and dust free, and almost unaffected by the turbulent conditions of the underlying level of the atmosphere. (Source: WRIGHT) RBO_relaxed.owl ENVO:01000539 biolink:NamedThing mesosphere The mesosphere is part of the earth's atmosphere which is between the stratosphere and the thermosphere in which temperature decreases with altitude to the atmosphere's absolute minimum RBO_relaxed.owl ENVO:01000540 biolink:NamedThing troposphere The lowest of the concentric layers of the atmosphere, occurring between the Earth's surface and the tropopause. It is the zone where atmospheric turbulence is at its greatest and where the bulk of the Earth's weather is generated. It contains almost all the water vapour and aerosols and three-quarters of the total gaseous mass of the atmosphere. Throughout the troposphere temperature decreases with height at a mean rate of 6.5°C/km and the whole zone is capped by either an inversion of temperature or an isothermal layer at the tropopause. (Source: WHIT) RBO_relaxed.owl ENVO:01000541 biolink:NamedThing thermosphere The thermosphere is a part of the earth's atmosphere that begins at about 50 miles (80 kilometers) above the earth's surface, extends to outer space, and is characterized by steadily increasing temperature with height RBO_relaxed.owl ENVO:01001681 biolink:NamedThing weather front A gaseous front which separates two masses of air with different densities and is a principal cause of meteorological phenomena. RBO_relaxed.owl ENVO:01000544 biolink:NamedThing boundary layer A boundary layer is a layer of fluid in the immediate vicinity of a bounding surface where the effects of viscosity are significant enough to distort the surrounding non-viscous flow. RBO_relaxed.owl ENVO:01001310 biolink:NamedThing liquid surface layer A surface layer which is composed primarily of some liquid. RBO_relaxed.owl ENVO:01000328 biolink:NamedThing dome swamp A dome swamp is a swamp which occurs in a depression where deeper waters at the centre of the swamp allow trees to grow taller relative to those in shallower regions of the depression. This creates a dome-like shape. RBO_relaxed.owl ENVO:01000335 biolink:NamedThing understory An understory is a layer of plant life which grows below the canopy without penetrating it. RBO_relaxed.owl ENVO:01000355 biolink:NamedThing vegetation layer A layer which is determined by a form of vegetation. RBO_relaxed.owl ENVO:01000336 biolink:NamedThing shrub layer A shrub layer is a layer of vegetation in a woodland or forest consisting of low, woody vegetation of frutescent form. RBO_relaxed.owl ENVO:01000337 biolink:NamedThing herb and fern layer A herb and fern layer is a layer of a forest or woodland which is composed of all vascular plant life that are one metre or less in height. RBO_relaxed.owl ENVO:01001242 biolink:NamedThing canopy A vegetation layer which is formed by a collection of individual plant crowns, themselves constituting part of the aboveground portion of a plant community. RBO_relaxed.owl ENVO:01000340 biolink:NamedThing alpine An altitudinal condition which inheres in a bearer by virtue of the bearer having a monthly mean temperature is less than 10 degrees Celsius and being located at altitudes above the tree line and below the snowline. RBO_relaxed.owl ENVO:01000342 biolink:NamedThing montane An altitudinal condition which inheres in a bearer by virtue of the bearer being located at an altitude between mid-altitude forests and the tree line. RBO_relaxed.owl ENVO:01000639 biolink:NamedThing planetary structural layer A planetary structural layer is laminar part of a terrestrial planet or other rocky body large enough to have differentiation by density. Planetary layers have differing physicochemical properties and composition. RBO_relaxed.owl ENVO:01001275 biolink:NamedThing solid layer A layer which is primarily composed of some solid material, allowing for non-solid parts such as interstitial pockets of gas or liquid. RBO_relaxed.owl ENVO:01001609 biolink:NamedThing cryospheric layer A layer which is part of a cryosphere. RBO_relaxed.owl ENVO:06105266 biolink:NamedThing soil layer A layer that is composed primarily of soil. RBO_relaxed.owl ENVO:01001792 biolink:NamedThing tropical broadleaf forest A broadleaf forest which is subject to tropical climate conditions. RBO_relaxed.owl ENVO:01000408 biolink:NamedThing environmental zone A site which has its extent determined by the presence or influence of one or more components of an environmental system or the processes occurring therein. RBO_relaxed.owl ENVO:01000413 biolink:NamedThing old plant A whole plant which is relatively old RBO_relaxed.owl PO:0000003 biolink:NamedThing whole plant A plant structure (PO:0005679) which is a whole organism. RBO_relaxed.owl ENVO:01000414 biolink:NamedThing young plant A whole plant which is relatively young. RBO_relaxed.owl ENVO:01000744 biolink:NamedThing human dwelling A self-contained constructed feature used by one or more households as a home, such as a house, apartment, mobile home, houseboat or other 'substantial' structure. A dwelling typically includes nearby outbuildings, sheds etc. within the curtilage of the property, excluding any 'open fields beyond'. It has significance in relation to search and seizure, conveyancing of real property, burglary, trespass, and land use planning. RBO_relaxed.owl ENVO:01000426 biolink:NamedThing room A building part which is separated from other building parts by one or more interior walls and, optionally, outdoor areas by one or more exterior walls. RBO_relaxed.owl ENVO:01000465 biolink:NamedThing building wall Building walls are bulding parts which serve to support roofs, floors and ceilings; enclose a space as part of the building envelope; give buildings form; and to provide shelter and security. RBO_relaxed.owl ENVO:01000470 biolink:NamedThing building envelope A building envelope is a building part composed of those building parts which physically separate the interior of a building from its surrounding environment. The building envelope provides resistance to air, water, heat, light, and noise transfer. The three basic elements of a building envelope are a weather barrier, air barrier, and thermal barrier. RBO_relaxed.owl ENVO:01000471 biolink:NamedThing ceiling RBO_relaxed.owl ENVO:01000472 biolink:NamedThing building roof A roof is the covering on the uppermost part of a building which provides protection from animals and weather, notably rain, but also heat, wind and sunlight. A roof is also the framing or structure which supports the covering RBO_relaxed.owl ENVO:01001224 biolink:NamedThing office A building part within which administrative work is done by an organisations users in order to support and realise the objectives of that organization. RBO_relaxed.owl ENVO:01000456 biolink:NamedThing concrete masonry unit A concrete masonry unit is a large, rectangular masonry unit primarily composed of concrete. RBO_relaxed.owl ENVO:01000475 biolink:NamedThing brick A brick is a masonry unit which is composed of kneaded clay-bearing soil, expanded clay aggregate, sand and lime, or concrete material, fire-hardened or air-dried. RBO_relaxed.owl ENVO:01000469 biolink:NamedThing exterior wall An exterior wall is a building wall which separates the interior of a building from the buildings surrounding environment. RBO_relaxed.owl ENVO:01000500 biolink:NamedThing brick exterior wall A brick exterior wall is an exterior wall that is built from bricks. RBO_relaxed.owl ENVO:01000506 biolink:NamedThing concrete exterior wall A concrete exterior wall is an exterior wall that is composed primarily of concrete. RBO_relaxed.owl ENVO:01000510 biolink:NamedThing sheet-iron building roof A sheet-iron building roof is a building roof that is built from sheets of iron. RBO_relaxed.owl ENVO:01000513 biolink:NamedThing asbestos building roof An asbestos building roof is a building roof that is built from asbestos. RBO_relaxed.owl ENVO:01000515 biolink:NamedThing tiled building roof A tile building roof is a building roof that is built using tiles. RBO_relaxed.owl ENVO:01000516 biolink:NamedThing toilet fixture A fixture which is used primarily for the collection and, in some cases, disposal of human urine and feces. RBO_relaxed.owl ENVO:01001673 biolink:NamedThing fluid surface layer A surface layer which is composed primarily of some liquid or gas. RBO_relaxed.owl ENVO:01001679 biolink:NamedThing fluid front A fluid interface which separates two fluid masses with differing properties. RBO_relaxed.owl ENVO:01000601 biolink:NamedThing motor vehicle A motor vehicle is a vehicle which is propelled by an engine or motor and that does not operate on rails. RBO_relaxed.owl ENVO:01001488 biolink:NamedThing aircraft A vehicle which is able to travel through air in an atmosphere. RBO_relaxed.owl ENVO:01000624 biolink:NamedThing hydrological condensation process Hydrological condensation is a process in which atmospheric water vapour undergoes a phase transition from the gas phase to the liquid phase. RBO_relaxed.owl ENVO:01000724 biolink:NamedThing condensation process Condensation is a process during which a gas undergoes a phase transition into a liquid. RBO_relaxed.owl ENVO:02500031 biolink:NamedThing hydrological process An environmental process which has water - in any of its states - as a participant. RBO_relaxed.owl ENVO:01000982 biolink:NamedThing water flow process A material transport process during which a volume of liquid water is transported due to a disequilibria in physical forces. RBO_relaxed.owl ENVO:01001549 biolink:NamedThing freezing of water into water ice A freezing process during which liquid water is transformed into water ice. RBO_relaxed.owl ENVO:01001618 biolink:NamedThing ice accumulation process A material accumulation process during which ice forms in an environmental material or an existing accumulation of ice increases in mass. RBO_relaxed.owl ENVO:01001619 biolink:NamedThing snow and ice accumulation process A material accumulation process during which a accumulation of snow and ice forms or increases in mass. RBO_relaxed.owl ENVO:03000055 biolink:NamedThing desublimation of water vapour into ice A desublimation process during which water vapour is frozen into water ice. RBO_relaxed.owl ENVO:01000635 biolink:NamedThing planetary landmass A landmass which is part of a planet. RBO_relaxed.owl ENVO:01001782 biolink:NamedThing landmass A large continuous area of land, either surrounded by sea or contiguous with another landmass. RBO_relaxed.owl ENVO:01000638 biolink:NamedThing planetary crust A planetary crust is the outermost solid shell of a rocky planet or natural satellite, which is chemically distinct from the underlying mantle. RBO_relaxed.owl ENVO:01000640 biolink:NamedThing planetary mantle A planetary mantle is a planetary layer which is an interior part of a terrestrial planet or other rocky body large enough to have differentiation by density. RBO_relaxed.owl ENVO:01000646 biolink:NamedThing lithosphere A lithosphere is the outermost shell of a terrestrial-type planet or natural satellite that is defined by its rigid mechanical properties. RBO_relaxed.owl ENVO:01001276 biolink:NamedThing water ice layer A solid layer which is primarily composed of some water-based ice. RBO_relaxed.owl ENVO:01000667 biolink:NamedThing geological fracture A geological fracture is any separation in a geologic formation, such as a joint or a fault that divides a mass of rock into two or more pieces. RBO_relaxed.owl ENVO:01001097 biolink:NamedThing tectonic plate A part of a lithosphere which is separated by other such parts by geographic faults or similar geomorphological discontinuities. RBO_relaxed.owl ENVO:01001781 biolink:NamedThing part of a landmass A solid astronomical body part which is part of the landmass of that body. RBO_relaxed.owl ENVO:01000668 biolink:NamedThing geological fault A geological fault is a planar fracture or discontinuity in a volume of rock, across which there has been significant displacement as a result of rock mass movement. RBO_relaxed.owl ENVO:01000669 biolink:NamedThing active geological fault An active fault is a fault that is likely to become the source of another earthquake sometime in the future. Geologists commonly consider faults to be active if there has been movement observed or evidence of seismic activity during the last 10,000 years. RBO_relaxed.owl ENVO:01000676 biolink:NamedThing contaminated air Contaminated air is air which has sufficient concentrations of environmental pollutants such that it may adversely affect a given ecosystem. RBO_relaxed.owl ENVO:01000828 biolink:NamedThing humid air Air which has increased levels of water vapour. RBO_relaxed.owl ENVO:01000677 biolink:NamedThing earthquake An earthquake is a process during which energy is released in an astronomical body's crust, causing the displacement of crustal parts and the generation of seismic waves. RBO_relaxed.owl ENVO:03000010 biolink:NamedThing material transport process A process during which material is displaced from its original location and transported either to a new location or back to the original location. RBO_relaxed.owl ENVO:01000694 biolink:NamedThing geological subsidence A material transport process during which a geological surface shifts downward relative to a datum such as sea-level. RBO_relaxed.owl ENVO:01000875 biolink:NamedThing precipitation process A precipitation process is a process in which a portion of some substance segregates from a material in which that substance or its precursors were dissolved or suspended in and settles due to a force such as gravity or centrifugal force. RBO_relaxed.owl ENVO:01001093 biolink:NamedThing tectonic movement A process during which pieces of a planetary crust and uppermost mantle move. RBO_relaxed.owl ENVO:01001334 biolink:NamedThing advective transport process A material transport process during which a volume of material is displaced due to a disequilibrium in physical forces and during which 1) the qualities that inhere in that volume and 2) the processes that are unfolding within it are largely unchanged. RBO_relaxed.owl ENVO:01001346 biolink:NamedThing erosion An action of exogenic processes (such as water flow or wind) which remove environmental material from one location on the surface of an astronomical body, transporting it to another location where it is deposited. RBO_relaxed.owl ENVO:01001367 biolink:NamedThing primary aerosol formation process A material transport process during which solid or liquid particles are directly introduced into a volume of gas. RBO_relaxed.owl ENVO:01003010 biolink:NamedThing convective transport process A material transport process which arises spontaneously due to physical heterogeneities in a portion of a material and forces which act throughout its volume. RBO_relaxed.owl ENVO:01003013 biolink:NamedThing material diffusion process A material transport process during which material moves from a region of higher concentration to a region of lower concentration. RBO_relaxed.owl OBO:RBO_00005009 biolink:NamedThing space flight Activity carried out by crewed or robotic vehicles outside the Earth's atmmosphere. RBO_relaxed.owl ENVO:01000678 biolink:NamedThing tectonic earthquake An earthquake caused by the sudden release of energy accumulated in an astronomical body's crust, as the elastic strain placed on constituent rock masses causes them to fracture. RBO_relaxed.owl ENVO:01001476 biolink:NamedThing body of liquid A liquid astronomical body part which is continuous and is delimited by physical discontinuities or non-liquid boundaries. RBO_relaxed.owl ENVO:01000689 biolink:NamedThing tsunami A tsunami is a process during which a series of waves is generated in a water body, typically an ocean or large lake, by the displacement of a large volume of water. Earthquakes, volcanic eruptions and other underwater explosions (including detonations of underwater nuclear devices), landslides, glacier calvings, meteorite impacts and other disturbances above or below water all have the potential to generate a tsunami. RBO_relaxed.owl ENVO:01000981 biolink:NamedThing mass liquid flow A process whereby a volume of liquid moves due to a disequilibrium of physical forces. RBO_relaxed.owl ENVO:01001342 biolink:NamedThing tidal flow process A water flow process during which movements of water masses caused by varying gravitational and rotational forces from astronomical bodies, combined with the rotation of the astronomical body containing the water mass, cause waters to undergo periodic depth oscillations (tides). RBO_relaxed.owl ENVO:01000703 biolink:NamedThing hydrological precipitation process Hydrological precipitation is a process during which any product of the condensation of atmospheric water vapour is pulled to the planetary surface by gravity. RBO_relaxed.owl ENVO:01001510 biolink:NamedThing material congelation process A material transformation process during which a material's viscosity increase either through a reduction in temperature, through chemical reactions, or other physical effects. RBO_relaxed.owl ENVO:01000726 biolink:NamedThing desublimation process Desublimation is a process in which a portion of some gas undergoes a phase transition into a portion of some solid. RBO_relaxed.owl ENVO:01001548 biolink:NamedThing freezing A material congelation process during which a liquid turns into a solid when its temperature is lowered below its melting point. RBO_relaxed.owl ENVO:01000743 biolink:NamedThing land consumption process A process in which natural ecosystems present over an expanse of land are removed and replaced with anthropogenic ecosystems. RBO_relaxed.owl ENVO:01000952 biolink:NamedThing anthropisation A process during which a natural environmental system is altered by human action. RBO_relaxed.owl ENVO:01001199 biolink:NamedThing terrestrial environmental zone An environmental zone which is bounded by material parts of a land mass or the atmosphere or space adjacent to it. RBO_relaxed.owl ENVO:01001200 biolink:NamedThing anthropised terrestrial environmental zone A terrestrial zone which is bounded by constructed, manufactured, or other anthropogenic material entities. RBO_relaxed.owl ENVO:01000755 biolink:NamedThing aeroform A part of an astronomical body which is primarily composed of a continuous volume of gaseous or aerosolised material held in shape by one or more environmental processes. RBO_relaxed.owl ENVO:01001645 biolink:NamedThing gaseous part of an atmosphere That part of an atmosphere which is composed of gaseous material. RBO_relaxed.owl ENVO:01001795 biolink:NamedThing ecosystem process An environmental process either driven by or primarily impacting the parts or emergent properties of an ecosystem. RBO_relaxed.owl ENVO:01001852 biolink:NamedThing energy transfer process A process during which one entity loses energy to another entity. RBO_relaxed.owl ENVO:02500003 biolink:NamedThing atmospheric process A process which occurs within an atmosphere. RBO_relaxed.owl ENVO:02500027 biolink:NamedThing anthropogenic environmental process An environmental process which is driven by the action of humans. RBO_relaxed.owl ENVO:02500036 biolink:NamedThing environmental pollution An environmental system process that results in the introduction of contaminants into an environment. RBO_relaxed.owl ENVO:03000008 biolink:NamedThing compaction process A physical process during which atoms, molecules, or other consituents of a material entity are forced closer together. RBO_relaxed.owl ENVO:03000009 biolink:NamedThing material accumulation process A process during which the mass of one or more materials, present within a given site, increases. RBO_relaxed.owl ENVO:03000043 biolink:NamedThing material transformation process A process during which a portion of some environmental material is converted into a different material or a collection of materials. RBO_relaxed.owl ENVO:01000792 biolink:NamedThing mass gaseous flow A process whereby a large volume of gas moves due to a disequilibrium of physical forces. RBO_relaxed.owl ENVO:01001747 biolink:NamedThing mass fluid flow An advective transport process during which a fluid moves. RBO_relaxed.owl ENVO:01000793 biolink:NamedThing atmospheric wind RBO_relaxed.owl ENVO:01001085 biolink:NamedThing atmospheric aerosol formation An aerosol formation process which occurs in an atmosphere. RBO_relaxed.owl ENVO:01000798 biolink:NamedThing plasma A material entity which is composed of a volume of unbound positive and negative particles in roughly equal numbers, conducts electricity, and possesses internal magnetic fields. RBO_relaxed.owl ENVO:01000799 biolink:NamedThing astronomical body An object which is naturally occuring, bound together by gravitational or electromagnetic forces, and surrounded by space. RBO_relaxed.owl ENVO:01000804 biolink:NamedThing astronomical object An object which is composed of one or more gravitationally bound structures that are associated with a position in space. RBO_relaxed.owl ENVO:01000800 biolink:NamedThing planet A planet is an astronomical body orbiting a star or stellar remnant that is massive enough to be rounded by its own gravity, is not massive enough to cause thermonuclear fusion, and has cleared its neighbouring region of planetesimals. RBO_relaxed.owl ENVO:01000801 biolink:NamedThing star An astronomical object which is composed primarily of luminous plasma held in a spherical form by gravitational forces. RBO_relaxed.owl ENVO:01001068 biolink:NamedThing meteoroid An astronomical body which is composed of rocky or metallic materials and is considerably smaller than asteroids. RBO_relaxed.owl ENVO:01001686 biolink:NamedThing mass of environmental material An object which is composed primarily of an environmental material RBO_relaxed.owl ENVO:01001122 biolink:NamedThing gas planet A planet which is primarily composed of hydrogen and helium. RBO_relaxed.owl ENVO:01001688 biolink:NamedThing mass of fluid An object which is composed primarily of a fluid. RBO_relaxed.owl ENVO:01001691 biolink:NamedThing mass of compounded environmental materials An mass of environmental materials which has appreciable quantities of several individual materials, such that the removal of one would convert the mass into a different entity. RBO_relaxed.owl ENVO:01001814 biolink:NamedThing organic object An object which is formed as a result of one or more biological processes and is composed primarily of organic material. RBO_relaxed.owl ENVO:01001008 biolink:NamedThing meteor A meteor is any matter- or energy-based entity which is located in the atmosphere of an astronomical body. RBO_relaxed.owl ENVO:01000819 biolink:NamedThing hydrosphere An astronomical body part which is composed of the combined mass of water found on, under, and over the surface of a planet. RBO_relaxed.owl ENVO:01000829 biolink:NamedThing water vapour saturated air Air which has a partial pressure of water vapour equal or near equal to its equilibrium vapor pressure at a given temperature. RBO_relaxed.owl ENVO:01000830 biolink:NamedThing water-based rainfall A hydrological precipitation process in which atmospheric water vapour condenses to form droplets of liquid water massive enough to fall to a planetary surface due to the planet's gravity. RBO_relaxed.owl ENVO:01000895 biolink:NamedThing snowfall A hydrological process in which irregular aggregates of snow fall to the surface of an astronomical body. RBO_relaxed.owl ENVO:01000831 biolink:NamedThing droplet A droplet is a small column of liquid, bounded completely or almost completely by free surfaces which maintains its shape due to the surface tension of the liquid. RBO_relaxed.owl ENVO:01001690 biolink:NamedThing mass of liquid An object which is composed primarily of a liquid. RBO_relaxed.owl ENVO:01000832 biolink:NamedThing raindrop A droplet formed by condensation of vapour in an atmosphere and which is sufficiently massive to overcome atmospheric resistance and fall to a planetary surface due to gravity. RBO_relaxed.owl ENVO:01000833 biolink:NamedThing water droplet A droplet of water RBO_relaxed.owl ENVO:01000834 biolink:NamedThing water raindrop RBO_relaxed.owl ENVO:01000846 biolink:NamedThing water ice crystal A crystal which is primarily composed of water ice. RBO_relaxed.owl ENVO:01000869 biolink:NamedThing area of scrub An area of a planet's surface which is primarily covered by a shrubs, young trees, or stunted trees.. The surfaces of this area are in contact with an atmospheric column extending from the planetary boundary layer to the planet's exosphere with little to no physical obstruction. RBO_relaxed.owl ENVO:01000883 biolink:NamedThing area of developed open space An area of a planet's surface which is primarily covered by cultivated or anthropically maintained vegetation planted for recreation, erosion control, or aesthetic purposes interspersed by constructed or manufactured objects and materials. This area is in contact with an atmospheric column extending from the planetary boundary layer to the planet's exosphere with little to no physical obstruction. RBO_relaxed.owl ENVO:01000888 biolink:NamedThing area of gramanoid or herbaceous vegetation An area of a planet's surface which is primarily covered by gramanoid or herbaceous vegetation and which is not subject to intensive management by humans. This area is in contact with an atmospheric column extending from the planetary boundary layer to the planet's exosphere with little to no physical obstruction. RBO_relaxed.owl ENVO:01000933 biolink:NamedThing residential building A human house which serves as a long-term shelter for its inhabitants and within which they store personal property. RBO_relaxed.owl ENVO:01001434 biolink:NamedThing anthropogenic ecosystem conversion process A process during which an ecosystem - natural or anthropised - is changed by the actions of humans. RBO_relaxed.owl ENVO:01000958 biolink:NamedThing terrestrial planet A planet that is composed primarily of silicate rocks or metals. RBO_relaxed.owl ENVO:01001136 biolink:NamedThing ocean planet A planet which has a surface layer that nearly completely or completely covered by water, and which has a substantial portion of its mass composed of water. RBO_relaxed.owl ENVO:01001137 biolink:NamedThing ice planet A planet which has a surface layer that nearly completely or completely covered by ice, and which has a substantial portion of its mass composed of ice. RBO_relaxed.owl ENVO:01001170 biolink:NamedThing active ecosystem management process A process during which an ecosystem, its parts, or the processes it participates in are modified by human intervention to accomplish an objective. RBO_relaxed.owl ENVO:01001500 biolink:NamedThing anthropogenic light pollution A pollution process during which artificial light with wavelengths in the visible spectrum is released into the environment. RBO_relaxed.owl ENVO:2000012 biolink:NamedThing anthropogenic generation of energy The generation of energy for use by humans RBO_relaxed.owl ENVO:01001001 biolink:NamedThing plant-associated environment An environmental system determined by a green plant. RBO_relaxed.owl ENVO:01001002 biolink:NamedThing animal-associated environment An environmental system determined by an animal. RBO_relaxed.owl ENVO:01001010 biolink:NamedThing hydrometeor A meteor which is primarily composed of water. RBO_relaxed.owl ENVO:01001012 biolink:NamedThing lithometeor A meteor which is primarily composed of rock. RBO_relaxed.owl ENVO:01001023 biolink:NamedThing radiation A process during which energy is emitted or transmitted in the form of waves or particles through space or a material medium. RBO_relaxed.owl ENVO:01001767 biolink:NamedThing structural collapse process A process during which the ability of a material entity to maintain its internal organisation fails, resulting in deformation and a breakdown of that organisation. RBO_relaxed.owl OBO:RBO_00002000 biolink:NamedThing radiation exposure The process by which an entity is exposed to electromagnetic or acoustic radiation radiation energy internally or externally. RBO_relaxed.owl OBO:RBO_00002117 biolink:NamedThing irradiation An energy transfer process in which energy in the form of particles or waves is transferred from one entity to another RBO_relaxed.owl ENVO:01001024 biolink:NamedThing particle radiation A radiation process during which energy is transmitted or emitted by means of fast-moving subatomic particles. RBO_relaxed.owl ENVO:01001026 biolink:NamedThing electromagnetic radiation A radiation process during which waves (or their quanta, photons) of the electromagnetic field propagate (radiate) through space carrying electromagnetic energy. RBO_relaxed.owl ENVO:01001054 biolink:NamedThing non-saline aerosol environment An environmental system which has its properties and dynamics determined by an aerosol with a low concentration of dissolved solutes. RBO_relaxed.owl ENVO:01001084 biolink:NamedThing particulate matter formation process A process during which microscopic solid or liquid objects are formed. RBO_relaxed.owl ENVO:01001205 biolink:NamedThing lithification A process during which sediments compact under pressure, expel connate fluids, and gradually become solid sedimentary rock. RBO_relaxed.owl ENVO:01001654 biolink:NamedThing aerosol formation process A material transformation process during which solid or liquid particles form and are suspended in a mass of air, thus creating an aerosol. RBO_relaxed.owl ENVO:01001086 biolink:NamedThing formation of a solid aerosol in an atmosphere A process during which an aerosol, consisting of solid particulates suspended in a gas, is formed in an atmosphere. RBO_relaxed.owl ENVO:01001087 biolink:NamedThing formation of a liquid aerosol in an atmosphere A process during which an aerosol, consisting of droplets of liquid suspended in gas, is formed in an atmosphere. RBO_relaxed.owl ENVO:01001088 biolink:NamedThing aerosolised liquids An aerosol which has non-gaseous parts that are primarily composed of liquid droplets. RBO_relaxed.owl ENVO:01001089 biolink:NamedThing aerosolised solids An aerosol which has non-gaseous parts that are primarily composed of solid particles. RBO_relaxed.owl ENVO:01001652 biolink:NamedThing atmospheric aerosol An aerosol that is suspended in an atmosphere. RBO_relaxed.owl ENVO:01001090 biolink:NamedThing formation of a solid aerosol from gaseous material in an atmosphere A process during which microscopic solid particulates are formed from gaseous materials in an atmosphere. RBO_relaxed.owl ENVO:01001639 biolink:NamedThing formation of a solid aerosol from liquid material in an atmosphere A process during which microscopic solid particulates are formed from liquid materials in an atmosphere. RBO_relaxed.owl ENVO:01001091 biolink:NamedThing formation of a liquid aerosol from gaseous material in an atmosphere A process during which microscopic liquid droplets are formed from gaseous materials in an atmosphere. RBO_relaxed.owl ENVO:01001098 biolink:NamedThing tectonic plate boundary A geomorphological feature which is formed where two or more tectonic plates move towards, away from, or along one another, resulting in deformation of the lithosphere. RBO_relaxed.owl ENVO:01001201 biolink:NamedThing marine environmental zone An environmental zone which is bounded by material parts of a marine environment. RBO_relaxed.owl ENVO:01001299 biolink:NamedThing atmospheric zone An environmental zone which is part of an atmosphere. RBO_relaxed.owl ENVO:01001776 biolink:NamedThing subsurface zone of an astronomical body An environmental zone which includes those regions of an astronomical body which are not exposed to its atmosphere or space. RBO_relaxed.owl ENVO:01001147 biolink:NamedThing helium planet A gas planet which has an atmosphere composed primarily of helium. RBO_relaxed.owl ENVO:01001155 biolink:NamedThing astrogeological gas An astrogeological volatile which is composed primarily of chemical compounds with boiling points around those of hydrogen and helium. RBO_relaxed.owl ENVO:01001164 biolink:NamedThing geodiversity A quality which inheres in a astronomical body or astronomical body part by virtue of the variation in its material composition, participation in geological processes, and the variation in is land- and hydroforms. RBO_relaxed.owl PATO:0001241 biolink:NamedThing physical object quality A quality which inheres in a continuant. RBO_relaxed.owl PATO:0000051 biolink:NamedThing morphology A quality of a single physical entity inhering in the bearer by virtue of the bearer's size or shape or structure. RBO_relaxed.owl PATO:0001995 biolink:NamedThing organismal quality A quality that inheres in an entire organism or part of an organism. RBO_relaxed.owl PATO:0002182 biolink:NamedThing molecular quality A quality which inheres in a molecular entity, a single molecule, atom, ion, radical etc. RBO_relaxed.owl PATO:0002303 biolink:NamedThing decreased object quality A quality of an object that has a value that is decreased compared to normal or average. RBO_relaxed.owl PATO:0002305 biolink:NamedThing increased object quality A quality of an object that has a value that is increased compared to normal or average. RBO_relaxed.owl PATO:0070044 biolink:NamedThing anatomical structure quality A quality of continuant that exist at the anatomical level of organisation and anything under it. This includes, but is not limited to, cells , tissues, and components. RBO_relaxed.owl OBO:RBO_00005025 biolink:NamedThing non-irradiated An organism or material entity kept unexposed to radiation, for purposes of comparison to a similar organism or material entity that has been exposed to radiation RBO_relaxed.owl OBO:RBO_00015010 biolink:NamedThing nanodosimetry A pattern (frequency and spatial distribution) of ionization events produced by energy deposition in time and space in a substance characterized by linear dimensions of the order of 1-100 nanometers. RBO_relaxed.owl OBO:RBO_00015014 biolink:NamedThing micrometric volume A volume of matter characterised by linear dimensions of the order of 0.5- 10's of microns, referred to as the "site" in microdosimetry. RBO_relaxed.owl ENVO:01001168 biolink:NamedThing ecosystem fragmentation process A process during which one or more parts of an ecosystem become causally isolated such that the direct flow or exchange of materials, resources, and energy between a given fragment and the remainder of the original system is severely curtailed or entirely halted. RBO_relaxed.owl ENVO:02500005 biolink:NamedThing land degradation A process which diminishes the functioning of an ecosystem located on land. RBO_relaxed.owl ENVO:02500012 biolink:NamedThing deforestation An ecosystem process during which the flora and fauna belonging to a forest are removed or destroyed. RBO_relaxed.owl ENVO:02500014 biolink:NamedThing forest process RBO_relaxed.owl ENVO:02500015 biolink:NamedThing forest area expansion RBO_relaxed.owl ENVO:01001617 biolink:NamedThing snow accumulation process A material accumulation process during which the mass of snow on a surface increases. RBO_relaxed.owl GO:0000003 biolink:NamedThing reproduction The production of new individuals that contain some portion of genetic material inherited from one or more parent organisms. RBO_relaxed.owl GO:0002376 biolink:NamedThing immune system process Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats. RBO_relaxed.owl GO:0008152 biolink:NamedThing metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. RBO_relaxed.owl GO:0009987 biolink:NamedThing cellular process Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. RBO_relaxed.owl GO:0022414 biolink:NamedThing reproductive process A biological process that directly contributes to the process of producing new individuals by one or two organisms. The new individuals inherit some proportion of their genetic material from the parent or parents. RBO_relaxed.owl GO:0032501 biolink:NamedThing multicellular organismal process Any biological process, occurring at the level of a multicellular organism, pertinent to its function. RBO_relaxed.owl GO:0032502 biolink:NamedThing developmental process A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition. RBO_relaxed.owl GO:0040007 biolink:NamedThing growth The increase in size or mass of an entire organism, a part of an organism or a cell. RBO_relaxed.owl GO:0040011 biolink:NamedThing locomotion Self-propelled movement of a cell or organism from one location to another. RBO_relaxed.owl GO:0042063 biolink:NamedThing gliogenesis The process that results in the generation of glial cells. This includes the production of glial progenitors and their differentiation into mature glia. RBO_relaxed.owl GO:0042592 biolink:NamedThing homeostatic process Any biological process involved in the maintenance of an internal steady state. RBO_relaxed.owl GO:0043473 biolink:NamedThing pigmentation The accumulation of pigment in an organism, tissue or cell, either by increased deposition or by increased number of cells. RBO_relaxed.owl GO:0044419 biolink:NamedThing biological process involved in interspecies interaction between organisms Any process evolved to enable an interaction with an organism of a different species. RBO_relaxed.owl GO:0048468 biolink:NamedThing cell development The cellular developmental process in which a specific cell progresses from an immature to a mature state. Cell development start once cell commitment has taken place. RBO_relaxed.owl GO:0050896 biolink:NamedThing response to stimulus Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism. RBO_relaxed.owl GO:0051179 biolink:NamedThing localization Any process in which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported, tethered to or otherwise maintained in a specific location. In the case of substances, localization may also be achieved via selective degradation. RBO_relaxed.owl GO:0065007 biolink:NamedThing biological regulation Any process that modulates a measurable attribute of any biological process, quality or function. RBO_relaxed.owl GO:0098754 biolink:NamedThing detoxification Any process that reduces or removes the toxicity of a toxic substance. These may include transport of the toxic substance away from sensitive areas and to compartments or complexes whose purpose is sequestration of the toxic substance. RBO_relaxed.owl ENVO:01001210 biolink:NamedThing defence against flooding A planned process during which an environmental system is modified to mitigate or nullify the impacts of flooding. RBO_relaxed.owl ENVO:02500042 biolink:NamedThing pollution control A planned process during which the amount of pollutants released into an environmental system is regulated. RBO_relaxed.owl ENVO:01001176 biolink:NamedThing environment associated with an aquatic invertebrate An environment which has its properties and composition largely determined by the presence of a metazoan which lacks a vetebral column and which has a habitat that is found in an aquatic environmental system. RBO_relaxed.owl ENVO:01001309 biolink:NamedThing liquid air-water interface layer A liquid surface layer which is in contact with air. RBO_relaxed.owl ENVO:01001192 biolink:NamedThing sediment surface The surface layer of a mass of sediment. RBO_relaxed.owl ENVO:01001206 biolink:NamedThing grassland ecosystem An ecosystem in which grasses (Graminae) are the dominant form of vegetation and determine the system's structure and dynamics. RBO_relaxed.owl ENVO:01001244 biolink:NamedThing cropland ecosystem An ecosystem which 1) is determined by communities of annual crops, perennial woody crops, or by actively tilled land, 2) is primarily used for agricultural activity, and 3) contains no village or larger human settlement. RBO_relaxed.owl ENVO:01001245 biolink:NamedThing woodland ecosystem An ecosystem which is determined by communities of plants with a tree growth form and in which members of those communities are spaced sufficiently far apart to allow sunlight to illuminate the understory. RBO_relaxed.owl ENVO:01001211 biolink:NamedThing stellar radiation An electromagnetic radiation process during which electromagnetic waves or their quanta are emitted from a star. RBO_relaxed.owl ENVO:01001501 biolink:NamedThing radiation from a manufactured product An electromagnetic radiation process during which electromagnetic waves or their quanta are emitted from a manufactured product. RBO_relaxed.owl ENVO:01001226 biolink:NamedThing terrestrial natural environment A natural environment which is located on a land mass. RBO_relaxed.owl ENVO:01001227 biolink:NamedThing aquatic natural environment A natural environment which is within a water body. RBO_relaxed.owl ENVO:01001239 biolink:NamedThing forest canopy RBO_relaxed.owl ENVO:01001240 biolink:NamedThing woodland canopy A canopy which is part of a woodland ecosystem. RBO_relaxed.owl ENVO:01001241 biolink:NamedThing crop canopy A canopy which is composed of the aboveground portion, or crowns, of a community of crop plants. RBO_relaxed.owl ENVO:01001683 biolink:NamedThing gaseous surface layer A fluid surface layer which is composed primarily of some gaseous material. RBO_relaxed.owl ENVO:02500002 biolink:NamedThing flooding A general and temporary condition of partial or complete inundation of normally dry land areas from the overflow of inland and/or tidal waters, and/or the unusual and rapid accumulation or runoff of surface waters from any source. A great flow along a watercourse or a flow causing inundation of lands not normally covered by water. RBO_relaxed.owl ENVO:03000127 biolink:NamedThing acid rainfall A water-based rainfall process during which water droplets with increased acidity fall towards a planetary surface. RBO_relaxed.owl ENVO:01001357 biolink:NamedThing desert A landform which has been rendered barren or partially barren by environmental extremes, especially by low rainfall. RBO_relaxed.owl ENVO:01001366 biolink:NamedThing aerosolised particle formation process A process during which particles suspended in a gaseous medium are formed. RBO_relaxed.owl ENVO:01001405 biolink:NamedThing laboratory environment An anthropogenic environment which is bounded by the building envelope of a laboratory and in which a system of manufactured products exert control on one or more of its environmental conditions. RBO_relaxed.owl ENVO:01001429 biolink:NamedThing land conversion process An anthropisation process during which terrestrial environments - natural or anthropised - or parts thereof are altered to facilitate human activities such as agriculture, settlement, or commerce. RBO_relaxed.owl ENVO:01001431 biolink:NamedThing land use process An anthropogenic environmental process which includes all human activities undertaken in a natural, semi-natural, or anthropised environment. RBO_relaxed.owl ENVO:01001437 biolink:NamedThing mining A planned environmental usage process during which a non-renewable resource such as petroleum, natural gas, or water is extracted from an ecosystem. RBO_relaxed.owl ENVO:01001444 biolink:NamedThing usage of an environment for transportation A planned environmental usage process during which an environment facilitates the movement of materials and material objects (persons or goods) from place to place, typically with the assistance of a vehicle. RBO_relaxed.owl ENVO:01001445 biolink:NamedThing usage of an environment for infrastructure and utilities A planned environmental usage process during which an environment supports 1) enterprises concerned with the provision to the public of essentials, such as electricity or water or 2) the basic network or foundation of capital facilities or community investments which are necessary to support economic and community activities. RBO_relaxed.owl ENVO:01001446 biolink:NamedThing usage of an environment for residential activity A planned environmental usage process during which an environment supports the settlement and dwelling of a community of humans. RBO_relaxed.owl ENVO:01001450 biolink:NamedThing usage of an environment for industry A planned environmental usage process during which an environment supports manufacturing facilities producing commodities that are sold with the expectation of recovering the total cost of production. RBO_relaxed.owl ENVO:01001451 biolink:NamedThing usage of an environment for business A planned environmental usage process during which an environment supports facilities associated with commerce or the earning of a livelihood through means other than manufacturing or the provision of a public service. RBO_relaxed.owl ENVO:01001433 biolink:NamedThing terrestrial mining A land use process during which materials of economic value are extracted from a planet, usually from an orebody, lode, vein, seam, reef or placer deposit. RBO_relaxed.owl ENVO:01001439 biolink:NamedThing marine mining A mining process which occurs in a marine ecosystem. RBO_relaxed.owl ENVO:01001440 biolink:NamedThing coal mining A mining process during which coal is extracted from the rocky portion of an astronomical body. RBO_relaxed.owl ENVO:01001491 biolink:NamedThing flattened elevation An elevation which is flattened across its highest surface. RBO_relaxed.owl ENVO:02500037 biolink:NamedThing air pollution A pollution process during which particulates or other contaminants are released into a portion of air. RBO_relaxed.owl ENVO:02500038 biolink:NamedThing soil pollution A pollution process during which contaminants are released into soil. RBO_relaxed.owl ENVO:02500039 biolink:NamedThing water pollution A pollution process during which contaminants are released into water. RBO_relaxed.owl ENVO:01001502 biolink:NamedThing visible spectrum radiation from a manufactured product Radiation from a manufactured product during which light between the wavelenghts of 380 nm and 760 nm is emitted. RBO_relaxed.owl ENVO:01001524 biolink:NamedThing frozen land Land which is below the freezing point of water. RBO_relaxed.owl ENVO:01001564 biolink:NamedThing rain An aggregate of raindrops falling to a planetary surface during a precipitation process. RBO_relaxed.owl OBO:RBO_00015033 biolink:NamedThing space radiation field The mix of charged and neutral atomic and subatomic particles and electromagnetic radiation suffusing a defined volume in an extraterrestrial environment at a given time. RBO_relaxed.owl ENVO:01001565 biolink:NamedThing water-based rain Rain which is composed of water droplets falling to a planetary surface during a rainfall process. RBO_relaxed.owl ENVO:01001570 biolink:NamedThing terrestrial ecoregion An ecoregion which is located on a landmass. RBO_relaxed.owl ENVO:01001581 biolink:NamedThing sea surface layer A surface layer which is part of an ocean or sea. RBO_relaxed.owl ENVO:01001614 biolink:NamedThing ice-bearing permafrost Permafrost which contains inclusions of water-based ice. RBO_relaxed.owl ENVO:01001856 biolink:NamedThing liquid accumulation process A material accumulation process during which the volume of liquid entity increases. RBO_relaxed.owl ENVO:03000036 biolink:NamedThing sedimentation in a water body A material accumulation process during which solid particles are pulled through a water body by gravitation or centrifugal force and which ends when they settle on a solid surface. RBO_relaxed.owl ENVO:01001620 biolink:NamedThing mass of ice and snow A object which is composed primarily of water-based snow and ice. RBO_relaxed.owl ENVO:03000111 biolink:NamedThing snow mass A mass of snow. RBO_relaxed.owl ENVO:01001680 biolink:NamedThing gaseous front A fluid front which is composed primarily of gaseous material and separates at least two gaseous masses. RBO_relaxed.owl ENVO:01001682 biolink:NamedThing air mass An object which is composed of a continuous mass of air. RBO_relaxed.owl ENVO:01001689 biolink:NamedThing mass of gas An object which is composed primarily of a gas. RBO_relaxed.owl ENVO:01001698 biolink:NamedThing polar front A weather front which separates air masses of tropical and polar origin. RBO_relaxed.owl ENVO:01001750 biolink:NamedThing straight-line wind A wind storm during which strong gusts of wind occur, transporting atmospheric gas in a linear fashion. RBO_relaxed.owl ENVO:01001860 biolink:NamedThing wind gust An atmospheric wind which 1) has an increased rate relative to other winds in the same region and 2) is followed by a lull. RBO_relaxed.owl ENVO:01001797 biolink:NamedThing tropical mixed forest A mixed forest which is subject to tropical climatic conditions. RBO_relaxed.owl ENVO:01001806 biolink:NamedThing tropical grassland A grassland ecosystem which is subject to tropical climatic conditions. RBO_relaxed.owl ENVO:01001865 biolink:NamedThing concentration of carbon dioxide in an atmosphere The concentration of carbon dioxide when measured in air that is part of an atmosphere. RBO_relaxed.owl PATO:0000033 biolink:NamedThing concentration of A quality inhering in a substance by virtue of the amount of the bearer's there is mixed with another substance. RBO_relaxed.owl ENVO:04000003 biolink:NamedThing concentration of carbon dioxide in soil The concentration of carbon dioxide when measured in soil. RBO_relaxed.owl ENVO:04000004 biolink:NamedThing concentration of carbon dioxide in air The concentration of carbon dioxide when measured in air. RBO_relaxed.owl ENVO:04000006 biolink:NamedThing concentration of carbon dioxide in seawater The concentration of carbon dioxide when measured in seawater. RBO_relaxed.owl ENVO:09000022 biolink:NamedThing concentration of clay in soil The concentration of a clay when measured in soil. RBO_relaxed.owl ENVO:09000023 biolink:NamedThing concentration of slit in soil The concentration of a slit when measured in soil. RBO_relaxed.owl ENVO:09000024 biolink:NamedThing concentration of sand in soil The concentration of a sand when measured in soil. RBO_relaxed.owl ENVO:09000026 biolink:NamedThing concentration of liquid water in soil The concentration of a liquid water when measured in soil. RBO_relaxed.owl ENVO:09000027 biolink:NamedThing concentration of salt in soil The concentration of a salt when measured in soil. RBO_relaxed.owl ENVO:09000030 biolink:NamedThing concentration of soil organic matter in soil The concentration of a soil organic matter when measured in soil. RBO_relaxed.owl ENVO:3100011 biolink:NamedThing concentration of dioxygen in liquid water The concentration of dioxygen when measured in liquid water. RBO_relaxed.owl ENVO:3100060 biolink:NamedThing concentration of dioxygen in sea water The concentration of dioxygen when measured in sea water. RBO_relaxed.owl ENVO:3200060 biolink:NamedThing concentration of oxygen in soil The concentration of oxygen when measured in soil. RBO_relaxed.owl ENVO:3200062 biolink:NamedThing concentration of iron molecular entity in soil The concentration of iron molecular entity when measured in soil. RBO_relaxed.owl ENVO:3200065 biolink:NamedThing concentration of sodium molecular entity in soil The concentration of sodium molecular entity when measured in soil. RBO_relaxed.owl ENVO:3200071 biolink:NamedThing concentration of organic molecular entity in soil The concentration of organic molecular entity when measured in soil. RBO_relaxed.owl PATO:0001655 biolink:NamedThing osmolarity A concentration quality inhering in a bearer by virtue of the bearer's amount of osmoles of solute per liter of solution. RBO_relaxed.owl PATO:0001842 biolink:NamedThing acidity A concentration quality inhering in a bearer by virtue of the bearer's containing acid (hydrogen ions). RBO_relaxed.owl ENVO:01003011 biolink:NamedThing convective A physical quality of a process which is characteristic of processes that transport material within a volume due to the combined effects of material property heterogeneity and body forces across that volume. RBO_relaxed.owl PATO:0002062 biolink:NamedThing physical quality of a process RBO_relaxed.owl ENVO:01003012 biolink:NamedThing advective A physical quality of a process which is characteristic of process that transport material without, themselves, changing the qualities of those materials or the processes that are unfolding within them. RBO_relaxed.owl PATO:0001309 biolink:NamedThing duration A process quality inhering in a bearer by virtue of the bearer's magnitude of the temporal extent between the starting and ending point. RBO_relaxed.owl OBO:RBO_00005072 biolink:NamedThing space flight Travel beyond the Earth's atmosphere RBO_relaxed.owl ENVO:02000091 biolink:NamedThing coal A combustible black or brownish-black sedimentary rock usually occurring in rock strata in layers or veins called coal beds or coal seams. RBO_relaxed.owl ENVO:02000095 biolink:NamedThing uranium ore Ore which contains uranium. RBO_relaxed.owl ENVO:02000096 biolink:NamedThing iron ore RBO_relaxed.owl ENVO:02000097 biolink:NamedThing gold ore RBO_relaxed.owl ENVO:02000098 biolink:NamedThing platinum ore RBO_relaxed.owl ENVO:02000099 biolink:NamedThing coal dust Dust which is derived from coal. RBO_relaxed.owl ENVO:02000100 biolink:NamedThing mineral dust Dust which is derived from mineral material. RBO_relaxed.owl ENVO:02000103 biolink:NamedThing metallic dust Dust which is composed primarily of some metallic material. RBO_relaxed.owl ENVO:02000104 biolink:NamedThing cement dust RBO_relaxed.owl ENVO:02000105 biolink:NamedThing clay dust Dust which is derived from clay material. RBO_relaxed.owl ENVO:02000109 biolink:NamedThing dust from plant parts RBO_relaxed.owl ENVO:02000137 biolink:NamedThing nuclear power reactor A nuclear reactor which is used as a source of power. RBO_relaxed.owl ENVO:02500001 biolink:NamedThing desertification A type of land degradation in which terrestrial ecosystem becomes increasingly dry, typically losing its bodies of water as well as vegetation and wildlife. RBO_relaxed.owl ENVO:02500011 biolink:NamedThing afforestation Establishment of a new forest by seeding or planting of nonforested land. RBO_relaxed.owl ENVO:02500032 biolink:NamedThing planned revegetation A planned process during which human agents establish plant communities in ecosystems which have previously been, partially or wholly, stripped of existing plant communities. RBO_relaxed.owl ENVO:02500028 biolink:NamedThing planetary erosion An action of exogenic processes (such as water flow or wind) which remove environmental material from one part of a planet's crust, transporting it to another location where it is deposited. RBO_relaxed.owl ENVO:02500043 biolink:NamedThing pollution monitoring A monitoring process that assays the level of environmental pollutants to determine the presence of effect of environmental pollution. RBO_relaxed.owl OBO:RBO_00002122 biolink:NamedThing environmental radiation monitoring Environmental monitoring that includes continual assay for radiation dose or quality. RBO_relaxed.owl OBO:RBO_00002123 biolink:NamedThing natural environment monitoring Monitoring within an environment which was not man-made. RBO_relaxed.owl OBO:RBO_00002124 biolink:NamedThing anthropogenic environment monitoring Monitoring within a man-made or constructed environment RBO_relaxed.owl ENVO:03000128 biolink:NamedThing acidic water-based rain Water-based rain which has increased acidity. RBO_relaxed.owl ENVO:03520007 biolink:NamedThing snow crystal A water ice crystal which is constituted by water molecules aligned in a hexagonal array. RBO_relaxed.owl ENVO:06105271 biolink:NamedThing soil texture Texture which inheres in soil. RBO_relaxed.owl PATO:0000150 biolink:NamedThing texture A morphologic quality inhering in a bearer by virtue of the bearer's relative size, organization and distribution of its surface elements or the representation or invention of the appearance of its surface; visual and tactile surface characteristics. RBO_relaxed.owl PATO:0002255 biolink:NamedThing grooved Texture quality inhering in a bearer by virtue of the bearer's being marked with one or more channels. RBO_relaxed.owl ENVO:06105304 biolink:NamedThing water-holding capacity of soil Water-holding capacity which inheres in some soil. RBO_relaxed.owl ENVO:09200000 biolink:NamedThing temperature of environmental material The temperature of some environmental material. RBO_relaxed.owl ENVO:09200001 biolink:NamedThing temperature of air The temperature of some air. RBO_relaxed.owl ENVO:09200012 biolink:NamedThing temperature of soil The temperature of some soil. RBO_relaxed.owl ENVO:09200014 biolink:NamedThing temperature of water The temperature of some water. RBO_relaxed.owl PATO:0001306 biolink:NamedThing decreased temperature A temperature which is relatively low. RBO_relaxed.owl PATO:0001985 biolink:NamedThing frozen A quality inhering in a bearer by virtue of the bearer's being kept below its freezing point. RBO_relaxed.owl ENVO:09200002 biolink:NamedThing environmental system process quality The quality of a environmental system process. RBO_relaxed.owl PATO:0001236 biolink:NamedThing process quality A quality which inheres in an process. RBO_relaxed.owl PATO:0002304 biolink:NamedThing increased process quality A quality of a process that has a value that is increased compared to normal or average. RBO_relaxed.owl OBO:RBO_00002021 biolink:NamedThing study modality The specific manner, characteristic, pattern of application, or the employment of any technology, approach or formal procedure to implement the study plan to generate a study type. RBO_relaxed.owl OBO:RBO_00015011 biolink:NamedThing particle track structure The complete set of spatial coordinates of energy deposition events along a particle track in matter RBO_relaxed.owl ENVO:09200004 biolink:NamedThing porosity of soil The porosity of some soil. RBO_relaxed.owl ENVO:09200009 biolink:NamedThing structure of soil The structure of some soil. RBO_relaxed.owl ENVO:09200008 biolink:NamedThing composition of soil The composition of some soil. RBO_relaxed.owl PATO:0000973 biolink:NamedThing porosity A structure quality inhering in a bearer by virtue of the bearer's disposition to admit the passage of gas or liquid through pores or interstices. RBO_relaxed.owl ENVO:09200034 biolink:NamedThing porosity of snow The porosity of some snow. RBO_relaxed.owl ENVO:09200035 biolink:NamedThing porosity of water ice The porosity of some water ice. RBO_relaxed.owl PATO:0000984 biolink:NamedThing porous A porosity quality inhering in a bearer by virtue of the bearer's being capable of admitting the passage of gas or liquid through pores or interstices. RBO_relaxed.owl PATO:0000025 biolink:NamedThing composition A single physical entity inhering in an bearer by virtue of the bearer's quantities or relative ratios of subparts. RBO_relaxed.owl ENVO:09200017 biolink:NamedThing composition of water The composition of some water. RBO_relaxed.owl PATO:0001759 biolink:NamedThing granular A composition quality inhering in a bearer by virtue of the bearer's containing granules. RBO_relaxed.owl PATO:0002462 biolink:NamedThing collagenous A composition quality inhering in an bearer by virtue of the bearer's consisting of collagen. RBO_relaxed.owl OBO:RBO_00015032 biolink:NamedThing radiation beam composition The types and characteristics of particles or waves that make up the radiation produced or emitted by a radiation source for use in a particular exposure context or protocol. The source may be artificial as in a particle accelerator or natural, in a controlled environment, such as a collimated beam from a radioactive isotope. RBO_relaxed.owl OBO:RBO_00015035 biolink:NamedThing radiation field composition Radiation field composition refers to the spectrum of types and characteristics of radiation present in a specific area or region where radiation is being used, emitted, absorbed, or measured. It describes the combination of different types of particles or waves that make up the radiation in a given field. RBO_relaxed.owl PATO:0000141 biolink:NamedThing structure A morphology quality inhering in a bearer by virtue of the bearer's relative position, shape, arrangements and connectivity of an organism's various parts; the pattern underlying its form. RBO_relaxed.owl PATO:0001411 biolink:NamedThing structured A structural quality inhering in a bearer by virtue of the bearer's having distinct structure. RBO_relaxed.owl PATO:0001412 biolink:NamedThing unstructured A structural quality inhering in a bearer by virtue of the bearer's lacking distinct structure. RBO_relaxed.owl PATO:0002014 biolink:NamedThing structure, cavities A structural quality that inheres in a bearer by virtue of the bearer's containing hollow areas. RBO_relaxed.owl PATO:0002124 biolink:NamedThing laminar A quality inhering in a bearer by virtue of the bearer's processing the form of a thin plate sheet or layer. RBO_relaxed.owl PATO:0002422 biolink:NamedThing acinar Pertaining to the individual parts making up an aggregate fruit like a many-lobed "berry," such as a raspberry. RBO_relaxed.owl PATO:0010001 biolink:NamedThing disconnected A structural quality inhering in the bearer by virtue of the bearer consisting of multiple structures lacking any physical connection to each other. RBO_relaxed.owl PATO:0015006 biolink:NamedThing polymeric A quality inhering in a structure by virtue of it consisting of many of repeated, similar or identical subunits, arranged in some orderly array. RBO_relaxed.owl PATO:0015008 biolink:NamedThing distensibility A quality inhering in a bearer by virtue of the extent to which the bearer is capable of being stretched or swollen. RBO_relaxed.owl ENVO:09200010 biolink:NamedThing acidity of soil The acidity of some soil. RBO_relaxed.owl ENVO:3100030 biolink:NamedThing acidity of water The acidity of some water. RBO_relaxed.owl PATO:0001428 biolink:NamedThing medium acidity A concentration quality inhering in a medium by virtue of the bearer's tendency to hydronate a specific reference base. RBO_relaxed.owl ENVO:09200013 biolink:NamedThing wetness of soil The wetness of some soil. RBO_relaxed.owl PATO:0001823 biolink:NamedThing wet A wetness quality inhering in a bearer by virtue of the bearer's being covered by a liquid. RBO_relaxed.owl PATO:0001824 biolink:NamedThing dry A wetness quality inhering in a bearer by virtue of the bearer's not being covered by a liquid. RBO_relaxed.owl ENVO:09200015 biolink:NamedThing humidity of soil The humidity of some soil. RBO_relaxed.owl PATO:0015009 biolink:NamedThing humidity A quality inhering in air by virtue of the partial pressure exerted by the bearer's water vapour content. RBO_relaxed.owl PATO:0015010 biolink:NamedThing increased humidity An increase in humidity. RBO_relaxed.owl ENVO:2000013 biolink:NamedThing generation of energy from coal RBO_relaxed.owl ENVO:2000016 biolink:NamedThing potential energy Energy possessed by an object because of its position relative to other objects, stresses within itself, its electric charge, or other factors. RBO_relaxed.owl ENVO:2000017 biolink:NamedThing kinetic energy Energy which is realised through motion. RBO_relaxed.owl ENVO:2000018 biolink:NamedThing mixed potential and kinetic energy Energy which is the sum of 1) kinetic energy and 2) potential energy. RBO_relaxed.owl ENVO:2000025 biolink:NamedThing nuclear energy potential energy that binds nucleons to form the atomic nucleus (and nuclear reactions). RBO_relaxed.owl ENVO:2000030 biolink:NamedThing radiant energy Potential energy which is stored in the fields of propagated by electromagnetic radiation. RBO_relaxed.owl ENVO:2000032 biolink:NamedThing thermal energy Kinetic energy which is realised through the microscopic motion of particles. RBO_relaxed.owl ENVO:2000034 biolink:NamedThing geothermal energy Thermal energy which propagates through a solid (typically rocky) astronomical body. RBO_relaxed.owl ENVO:2000035 biolink:NamedThing stellar radiation energy RBO_relaxed.owl ENVO:2100004 biolink:NamedThing integumental system environment RBO_relaxed.owl GO:0000011 biolink:NamedThing vacuole inheritance The distribution of vacuoles into daughter cells after mitosis or meiosis, mediated by interactions between vacuoles and the cytoskeleton. RBO_relaxed.owl GO:0007033 biolink:NamedThing vacuole organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a vacuole. RBO_relaxed.owl GO:0097576 biolink:NamedThing vacuole fusion Merging of two or more vacuoles, or of vacuoles and vesicles within a cell to form a single larger vacuole. RBO_relaxed.owl GO:0048308 biolink:NamedThing organelle inheritance The partitioning of organelles between daughter cells at cell division. RBO_relaxed.owl GO:0048313 biolink:NamedThing Golgi inheritance The partitioning of Golgi apparatus between daughter cells at cell division. RBO_relaxed.owl GO:0000070 biolink:NamedThing mitotic sister chromatid segregation The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner. One homolog of each morphologic type goes into each of the resulting chromosome sets. RBO_relaxed.owl GO:0000819 biolink:NamedThing sister chromatid segregation The cell cycle process in which sister chromatids are organized and then physically separated and apportioned to two or more sets. RBO_relaxed.owl GO:0098813 biolink:NamedThing nuclear chromosome segregation The process in which genetic material, in the form of nuclear chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. Nuclear chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles. RBO_relaxed.owl GO:0016321 biolink:NamedThing female meiosis chromosome segregation The cell cycle process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets during the meiotic cell cycle in a female. RBO_relaxed.owl GO:0045132 biolink:NamedThing meiotic chromosome segregation The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets during M phase of the meiotic cell cycle. RBO_relaxed.owl GO:1903047 biolink:NamedThing mitotic cell cycle process A process that is part of the mitotic cell cycle. RBO_relaxed.owl GO:0007076 biolink:NamedThing mitotic chromosome condensation The cell cycle process in which chromatin structure is compacted prior to and during mitosis in eukaryotic cells. RBO_relaxed.owl GO:0007077 biolink:NamedThing mitotic nuclear membrane disassembly The mitotic cell cycle process in which the controlled partial or complete breakdown of the nuclear membranes during occurs during mitosis. RBO_relaxed.owl GO:0101024 biolink:NamedThing mitotic nuclear membrane organization A mitotic cell cycle process which results in the assembly, arrangement, or disassembly of the nuclear inner or outer membrane during mitosis. RBO_relaxed.owl GO:0140014 biolink:NamedThing mitotic nuclear division A mitotic cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell. RBO_relaxed.owl GO:1902850 biolink:NamedThing microtubule cytoskeleton organization involved in mitosis Any microtubule cytoskeleton organization that is involved in mitosis. RBO_relaxed.owl GO:0000139 biolink:NamedThing Golgi membrane The lipid bilayer surrounding any of the compartments of the Golgi apparatus. RBO_relaxed.owl GO:0016020 biolink:NamedThing membrane A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. RBO_relaxed.owl GO:0005640 biolink:NamedThing nuclear outer membrane The outer, i.e. cytoplasm-facing, lipid bilayer of the nuclear envelope; continuous with the endoplasmic reticulum of the cell and sometimes studded with ribosomes. RBO_relaxed.owl GO:0005774 biolink:NamedThing vacuolar membrane The lipid bilayer surrounding the vacuole and separating its contents from the cytoplasm of the cell. RBO_relaxed.owl GO:0005886 biolink:NamedThing plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. RBO_relaxed.owl GO:0012506 biolink:NamedThing vesicle membrane The lipid bilayer surrounding any membrane-bounded vesicle in the cell. RBO_relaxed.owl GO:0019867 biolink:NamedThing outer membrane The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites. RBO_relaxed.owl GO:0030658 biolink:NamedThing transport vesicle membrane The lipid bilayer surrounding a transport vesicle. RBO_relaxed.owl GO:0030659 biolink:NamedThing cytoplasmic vesicle membrane The lipid bilayer surrounding a cytoplasmic vesicle. RBO_relaxed.owl GO:0030660 biolink:NamedThing Golgi-associated vesicle membrane The lipid bilayer surrounding a vesicle associated with the Golgi apparatus. RBO_relaxed.owl GO:0030667 biolink:NamedThing secretory granule membrane The lipid bilayer surrounding a secretory granule. RBO_relaxed.owl GO:0031090 biolink:NamedThing organelle membrane A membrane that is one of the two lipid bilayers of an organelle envelope or the outermost membrane of single membrane bound organelle. RBO_relaxed.owl GO:0031253 biolink:NamedThing cell projection membrane The portion of the plasma membrane surrounding a plasma membrane bounded cell surface projection. RBO_relaxed.owl GO:0031965 biolink:NamedThing nuclear membrane Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space. RBO_relaxed.owl GO:0031968 biolink:NamedThing organelle outer membrane The outer, i.e. cytoplasm-facing in a cellular organelle, lipid bilayer of an organelle envelope. RBO_relaxed.owl GO:0032127 biolink:NamedThing dense core granule membrane The lipid bilayer surrounding a dense core granule. RBO_relaxed.owl GO:0032589 biolink:NamedThing neuron projection membrane The portion of the plasma membrane surrounding a neuron projection. RBO_relaxed.owl GO:0042175 biolink:NamedThing nuclear outer membrane-endoplasmic reticulum membrane network The continuous network of membranes encompassing the nuclear outer membrane and the endoplasmic reticulum membrane. RBO_relaxed.owl GO:0042589 biolink:NamedThing zymogen granule membrane The lipid bilayer surrounding a zymogen granule. RBO_relaxed.owl GO:0060170 biolink:NamedThing ciliary membrane The portion of the plasma membrane surrounding a cilium. RBO_relaxed.owl GO:0090741 biolink:NamedThing pigment granule membrane Any membrane that is part of a pigment granule. RBO_relaxed.owl GO:0098588 biolink:NamedThing bounding membrane of organelle The lipid bilayer that forms the outer-most layer of an organelle. RBO_relaxed.owl GO:0098590 biolink:NamedThing plasma membrane region A membrane that is a (regional) part of the plasma membrane. RBO_relaxed.owl GO:0099012 biolink:NamedThing neuronal dense core vesicle membrane The lipid bilayer surrounding a neuronal dense core vesicle. RBO_relaxed.owl GO:0099501 biolink:NamedThing exocytic vesicle membrane The lipid bilayer surrounding an exocytic vesicle. RBO_relaxed.owl GO:0000226 biolink:NamedThing microtubule cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins. RBO_relaxed.owl GO:0007010 biolink:NamedThing cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures. RBO_relaxed.owl GO:0030036 biolink:NamedThing actin cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins. RBO_relaxed.owl GO:0030952 biolink:NamedThing establishment or maintenance of cytoskeleton polarity Any cellular process that results in the specification, formation or maintenance of polarized cytoskeletal structures. RBO_relaxed.owl GO:0099187 biolink:NamedThing presynaptic cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures and their associated proteins in the presynaptic cytoskeleton. RBO_relaxed.owl GO:0099188 biolink:NamedThing postsynaptic cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising cytoskeletal filaments and their associated proteins in the postsynaptic cytoskeleton. RBO_relaxed.owl GO:0007017 biolink:NamedThing microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. RBO_relaxed.owl GO:0007018 biolink:NamedThing microtubule-based movement A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules. RBO_relaxed.owl GO:0099118 biolink:NamedThing microtubule-based protein transport A microtubule-based process that results in the transport of proteins. RBO_relaxed.owl GO:0016043 biolink:NamedThing cellular component organization A process that results in the assembly, arrangement of constituent parts, or disassembly of a cellular component. RBO_relaxed.owl GO:0006325 biolink:NamedThing chromatin organization The assembly or remodeling of chromatin composed of DNA complexed with histones, other associated proteins, and sometimes RNA. RBO_relaxed.owl GO:0006996 biolink:NamedThing organelle organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane. RBO_relaxed.owl GO:0006997 biolink:NamedThing nucleus organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nucleus. RBO_relaxed.owl GO:0006998 biolink:NamedThing nuclear envelope organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear envelope. RBO_relaxed.owl GO:0007000 biolink:NamedThing nucleolus organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nucleolus. RBO_relaxed.owl GO:0007009 biolink:NamedThing plasma membrane organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the plasma membrane. RBO_relaxed.owl GO:0007015 biolink:NamedThing actin filament organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking. RBO_relaxed.owl GO:0007028 biolink:NamedThing cytoplasm organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the cytoplasm. The cytoplasm is all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. RBO_relaxed.owl GO:0007030 biolink:NamedThing Golgi organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus. RBO_relaxed.owl GO:0007528 biolink:NamedThing neuromuscular junction development A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuromuscular junction. RBO_relaxed.owl GO:0010256 biolink:NamedThing endomembrane system organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endomembrane system. RBO_relaxed.owl GO:0016050 biolink:NamedThing vesicle organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a vesicle. RBO_relaxed.owl GO:0016325 biolink:NamedThing oocyte microtubule cytoskeleton organization Formation and maintenance of a polarized microtubule array originating from a microtubule-organizing center (MTOC) in the oocyte. An example of this is found in Drosophila melanogaster. RBO_relaxed.owl GO:0022411 biolink:NamedThing cellular component disassembly A cellular process that results in the breakdown of a cellular component. RBO_relaxed.owl GO:0022607 biolink:NamedThing cellular component assembly The aggregation, arrangement and bonding together of a cellular component. RBO_relaxed.owl GO:0030030 biolink:NamedThing cell projection organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a prolongation or process extending from a cell, e.g. a flagellum or axon. RBO_relaxed.owl GO:0030198 biolink:NamedThing extracellular matrix organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix. RBO_relaxed.owl GO:0030199 biolink:NamedThing collagen fibril organization Any process that determines the size and arrangement of collagen fibrils within an extracellular matrix. RBO_relaxed.owl GO:0031032 biolink:NamedThing actomyosin structure organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures containing both actin and myosin or paramyosin. The myosin may be organized into filaments. RBO_relaxed.owl GO:0031122 biolink:NamedThing cytoplasmic microtubule organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins in the cytoplasm of a cell. RBO_relaxed.owl GO:0032528 biolink:NamedThing microvillus organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a microvillus, a thin cylindrical membrane-covered projection on the surface of a cell. RBO_relaxed.owl GO:0033363 biolink:NamedThing secretory granule organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a secretory granule. A secretory granule is a small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. RBO_relaxed.owl GO:0034330 biolink:NamedThing cell junction organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cell junction. A cell junction is a specialized region of connection between two cells or between a cell and the extracellular matrix. RBO_relaxed.owl GO:0043062 biolink:NamedThing extracellular structure organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures in the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane, and also covers the host cell environment outside an intracellular parasite. RBO_relaxed.owl GO:0043933 biolink:NamedThing protein-containing complex organization Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a protein complex. RBO_relaxed.owl GO:0044782 biolink:NamedThing cilium organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole. RBO_relaxed.owl GO:0045214 biolink:NamedThing sarcomere organization The myofibril assembly process that results in the organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs. RBO_relaxed.owl GO:0045229 biolink:NamedThing external encapsulating structure organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of external structures that lie outside the plasma membrane and surround the entire cell. RBO_relaxed.owl GO:0048753 biolink:NamedThing pigment granule organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a pigment granule. RBO_relaxed.owl GO:0051276 biolink:NamedThing chromosome organization A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome. RBO_relaxed.owl GO:0061024 biolink:NamedThing membrane organization A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. RBO_relaxed.owl GO:0061109 biolink:NamedThing dense core granule organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a dense core granule. A dense core granule is a secretory organelle found in endocrine cells. RBO_relaxed.owl GO:0061572 biolink:NamedThing actin filament bundle organization A process that results in the assembly, arrangement of constituent parts, or disassembly of an actin filament bundle. RBO_relaxed.owl GO:0071711 biolink:NamedThing basement membrane organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the basement membrane. RBO_relaxed.owl GO:0071763 biolink:NamedThing nuclear membrane organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear inner or outer membrane. RBO_relaxed.owl GO:0071764 biolink:NamedThing nuclear outer membrane organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear outer membrane. RBO_relaxed.owl GO:0071824 biolink:NamedThing protein-DNA complex organization Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a protein-DNA complex. RBO_relaxed.owl GO:0071826 biolink:NamedThing protein-RNA complex organization Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a ribonucleoprotein complex. RBO_relaxed.owl GO:0097435 biolink:NamedThing supramolecular fiber organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a supramolecular fiber, a polymer consisting of an indefinite number of protein or protein complex subunits that have polymerised to form a fiber-shaped structure. RBO_relaxed.owl GO:0098974 biolink:NamedThing postsynaptic actin cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins in the postsynaptic actin cytoskeleton. RBO_relaxed.owl GO:0099014 biolink:NamedThing neuronal dense core vesicle organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuronal dense core vesicle. RBO_relaxed.owl GO:0099140 biolink:NamedThing presynaptic actin cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins in the presynaptic actin cytoskeleton. RBO_relaxed.owl GO:0099172 biolink:NamedThing presynapse organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a presynapse. RBO_relaxed.owl GO:0099173 biolink:NamedThing postsynapse organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a postsynapse. RBO_relaxed.owl GO:0106027 biolink:NamedThing neuron projection organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a prolongation or process extending from a neuron, e.g. an axon, or a dendrite. RBO_relaxed.owl GO:0120036 biolink:NamedThing plasma membrane bounded cell projection organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a plasma membrane bounded prolongation or process extending from a cell, e.g. a cilium or axon. RBO_relaxed.owl GO:0000228 biolink:NamedThing nuclear chromosome A chromosome that encodes the nuclear genome and is found in the nucleus of a eukaryotic cell during the cell cycle phases when the nucleus is intact. RBO_relaxed.owl GO:0005694 biolink:NamedThing chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. RBO_relaxed.owl GO:0000271 biolink:NamedThing polysaccharide biosynthetic process The chemical reactions and pathways resulting in the formation of a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically. RBO_relaxed.owl GO:0005976 biolink:NamedThing polysaccharide metabolic process The chemical reactions and pathways involving a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically. RBO_relaxed.owl GO:0000272 biolink:NamedThing polysaccharide catabolic process The chemical reactions and pathways resulting in the breakdown of a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically. RBO_relaxed.owl GO:0044042 biolink:NamedThing glucan metabolic process The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. RBO_relaxed.owl GO:0009058 biolink:NamedThing biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. RBO_relaxed.owl GO:0005978 biolink:NamedThing glycogen biosynthetic process The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues. RBO_relaxed.owl GO:0006023 biolink:NamedThing aminoglycan biosynthetic process The chemical reactions and pathways resulting in the formation of aminoglycans, any polymer containing amino groups that consists of more than about 10 monosaccharide residues joined to each other by glycosidic linkages. RBO_relaxed.owl GO:0006024 biolink:NamedThing glycosaminoglycan biosynthetic process The chemical reactions and pathways resulting in the formation of glycosaminoglycans, any of a group of polysaccharides that contain amino sugars. RBO_relaxed.owl GO:0006094 biolink:NamedThing gluconeogenesis The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol. RBO_relaxed.owl GO:0006412 biolink:NamedThing translation The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome. RBO_relaxed.owl GO:0006694 biolink:NamedThing steroid biosynthetic process The chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus; includes de novo formation and steroid interconversion by modification. RBO_relaxed.owl GO:0006699 biolink:NamedThing bile acid biosynthetic process The chemical reactions and pathways resulting in the formation of bile acids, any of a group of steroid carboxylic acids occurring in bile. RBO_relaxed.owl GO:0008292 biolink:NamedThing acetylcholine biosynthetic process The chemical reactions and pathways resulting in the formation of acetylcholine, the acetic acid ester of the organic base choline. RBO_relaxed.owl GO:0008610 biolink:NamedThing lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. RBO_relaxed.owl GO:0008652 biolink:NamedThing amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents. RBO_relaxed.owl GO:0009059 biolink:NamedThing macromolecule biosynthetic process The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. RBO_relaxed.owl GO:0009101 biolink:NamedThing glycoprotein biosynthetic process The chemical reactions and pathways resulting in the formation of glycoproteins, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide. RBO_relaxed.owl GO:0009250 biolink:NamedThing glucan biosynthetic process The chemical reactions and pathways resulting in the formation of glucans, polysaccharides consisting only of glucose residues. RBO_relaxed.owl GO:0009309 biolink:NamedThing amine biosynthetic process The chemical reactions and pathways resulting in the formation of any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom. RBO_relaxed.owl GO:0009713 biolink:NamedThing catechol-containing compound biosynthetic process The chemical reactions and pathways resulting in the formation of catechol-containing compounds. Catechol is a compound containing a pyrocatechol nucleus or substituent. RBO_relaxed.owl GO:0009821 biolink:NamedThing alkaloid biosynthetic process The chemical reactions and pathways resulting in the formation of alkaloids, nitrogen-containing natural products which are not otherwise classified as nonprotein amino acids, amines, peptides, amines, cyanogenic glycosides, glucosinolates, cofactors, phytohormones, or primary metabolite (such as purine or pyrimidine bases). RBO_relaxed.owl GO:0016051 biolink:NamedThing carbohydrate biosynthetic process The chemical reactions and pathways resulting in the formation of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. RBO_relaxed.owl GO:0016053 biolink:NamedThing organic acid biosynthetic process The chemical reactions and pathways resulting in the formation of organic acids, any acidic compound containing carbon in covalent linkage. RBO_relaxed.owl GO:0018130 biolink:NamedThing heterocycle biosynthetic process The chemical reactions and pathways resulting in the formation of heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings). RBO_relaxed.owl GO:0019319 biolink:NamedThing hexose biosynthetic process The chemical reactions and pathways resulting in the formation of hexose, any monosaccharide with a chain of six carbon atoms in the molecule. RBO_relaxed.owl GO:0019413 biolink:NamedThing acetate biosynthetic process The chemical reactions and pathways resulting in the formation of acetate, the anion of acetic acid. RBO_relaxed.owl GO:0019438 biolink:NamedThing aromatic compound biosynthetic process The chemical reactions and pathways resulting in the formation of aromatic compounds, any substance containing an aromatic carbon ring. RBO_relaxed.owl GO:0030213 biolink:NamedThing hyaluronan biosynthetic process The chemical reactions and pathways resulting in the formation of hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine. RBO_relaxed.owl GO:0032774 biolink:NamedThing RNA biosynthetic process The chemical reactions and pathways resulting in the formation of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. Includes polymerization of ribonucleotide monomers. Refers not only to transcription but also to e.g. viral RNA replication. RBO_relaxed.owl GO:0032964 biolink:NamedThing collagen biosynthetic process The chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%). RBO_relaxed.owl GO:0033014 biolink:NamedThing tetrapyrrole biosynthetic process The chemical reactions and pathways leading to the formation of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next. RBO_relaxed.owl GO:0034654 biolink:NamedThing nucleobase-containing compound biosynthetic process The chemical reactions and pathways resulting in the formation of nucleobases, nucleosides, nucleotides and nucleic acids. RBO_relaxed.owl GO:0035835 biolink:NamedThing indole alkaloid biosynthetic process The chemical reactions and pathways resulting in the formation of an indole alkaloid, an alkaloid containing an indole skeleton. RBO_relaxed.owl GO:0042181 biolink:NamedThing ketone biosynthetic process The chemical reactions and pathways resulting in the formation of ketones, a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups. RBO_relaxed.owl GO:0042421 biolink:NamedThing norepinephrine biosynthetic process The chemical reactions and pathways resulting in the formation of norepinephrine, a hormone secreted by the adrenal medulla, and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts in the central nervous system. It is also the demethylated biosynthetic precursor of epinephrine. RBO_relaxed.owl GO:0042423 biolink:NamedThing catecholamine biosynthetic process The chemical reactions and pathways resulting in the formation of any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine. RBO_relaxed.owl GO:0042427 biolink:NamedThing serotonin biosynthetic process The chemical reactions and pathways resulting in the formation of serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties. RBO_relaxed.owl GO:0042435 biolink:NamedThing indole-containing compound biosynthetic process The chemical reactions and pathways resulting in the formation of compounds that contain an indole (2,3-benzopyrrole) skeleton. RBO_relaxed.owl GO:0043043 biolink:NamedThing peptide biosynthetic process The chemical reactions and pathways resulting in the formation of peptides, compounds of 2 or more (but usually less than 100) amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another. This may include the translation of a precursor protein and its subsequent processing into a functional peptide. RBO_relaxed.owl GO:0043604 biolink:NamedThing amide biosynthetic process The chemical reactions and pathways resulting in the formation of an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group. RBO_relaxed.owl GO:0043650 biolink:NamedThing dicarboxylic acid biosynthetic process The chemical reactions and pathways resulting in the formation of dicarboxylic acids, any organic acid containing two carboxyl (-COOH) groups. RBO_relaxed.owl GO:0044249 biolink:NamedThing cellular biosynthetic process The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells. RBO_relaxed.owl GO:0044272 biolink:NamedThing sulfur compound biosynthetic process The chemical reactions and pathways resulting in the formation of compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione. RBO_relaxed.owl GO:0044283 biolink:NamedThing small molecule biosynthetic process The chemical reactions and pathways resulting in the formation of small molecules, any low molecular weight, monomeric, non-encoded molecule. RBO_relaxed.owl GO:0044550 biolink:NamedThing secondary metabolite biosynthetic process The chemical reactions and pathways resulting in the formation of secondary metabolites, the compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon. RBO_relaxed.owl GO:0045222 biolink:NamedThing CD4 biosynthetic process The chemical reactions and pathways resulting in the formation of CD4, a CD marker that occurs on T-helper cells and is involved in MHC class II restricted interactions. RBO_relaxed.owl GO:0046112 biolink:NamedThing nucleobase biosynthetic process The chemical reactions and pathways resulting in the formation of a nucleobase, a nitrogenous base that is a constituent of a nucleic acid. RBO_relaxed.owl GO:0046189 biolink:NamedThing phenol-containing compound biosynthetic process The chemical reactions and pathways resulting in the formation of a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring. RBO_relaxed.owl GO:0046219 biolink:NamedThing indolalkylamine biosynthetic process The chemical reactions and pathways resulting in the formation of indolalkylamines, indole or indole derivatives containing a primary, secondary, or tertiary amine group. RBO_relaxed.owl GO:0046364 biolink:NamedThing monosaccharide biosynthetic process The chemical reactions and pathways resulting in the formation of monosaccharides, polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms. RBO_relaxed.owl GO:0046394 biolink:NamedThing carboxylic acid biosynthetic process The chemical reactions and pathways resulting in the formation of carboxylic acids, any organic acid containing one or more carboxyl (-COOH) groups. RBO_relaxed.owl GO:0071897 biolink:NamedThing DNA biosynthetic process The biosynthetic process resulting in the formation of DNA. RBO_relaxed.owl GO:0072330 biolink:NamedThing monocarboxylic acid biosynthetic process The chemical reactions and pathways resulting in the formation of monocarboxylic acids, any organic acid containing one carboxyl (-COOH) group. RBO_relaxed.owl GO:1900620 biolink:NamedThing acetate ester biosynthetic process The chemical reactions and pathways resulting in the formation of an acetate esteran acetate ester, any carboxylic ester where the carboxylic acid component is acetic acid. RBO_relaxed.owl GO:1901137 biolink:NamedThing carbohydrate derivative biosynthetic process The chemical reactions and pathways resulting in the formation of carbohydrate derivative. RBO_relaxed.owl GO:1901162 biolink:NamedThing primary amino compound biosynthetic process The chemical reactions and pathways resulting in the formation of primary amino compound. RBO_relaxed.owl GO:1901362 biolink:NamedThing organic cyclic compound biosynthetic process The chemical reactions and pathways resulting in the formation of organic cyclic compound. RBO_relaxed.owl GO:1901566 biolink:NamedThing organonitrogen compound biosynthetic process The chemical reactions and pathways resulting in the formation of organonitrogen compound. RBO_relaxed.owl GO:1901576 biolink:NamedThing organic substance biosynthetic process The chemical reactions and pathways resulting in the formation of an organic substance, any molecular entity containing carbon. RBO_relaxed.owl GO:1901607 biolink:NamedThing alpha-amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of an alpha-amino acid. RBO_relaxed.owl GO:1901617 biolink:NamedThing organic hydroxy compound biosynthetic process The chemical reactions and pathways resulting in the formation of organic hydroxy compound. RBO_relaxed.owl GO:0006414 biolink:NamedThing translational elongation The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis. RBO_relaxed.owl GO:0010467 biolink:NamedThing gene expression The process in which a gene's sequence is converted into a mature gene product (protein or RNA). This includes the production of an RNA transcript and its processing, as well as translation and maturation for protein-coding genes.|The process in which a gene's sequence is converted into a mature gene product (protein or RNA). This includes the production of an RNA transcript and its processing, translation and maturation for protein-coding genes. RBO_relaxed.owl GO:0009056 biolink:NamedThing catabolic process The chemical reactions and pathways resulting in the breakdown of substances, including the breakdown of carbon compounds with the liberation of energy for use by the cell or organism. RBO_relaxed.owl GO:0005980 biolink:NamedThing glycogen catabolic process The chemical reactions and pathways resulting in the breakdown of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues. RBO_relaxed.owl GO:0006007 biolink:NamedThing glucose catabolic process The chemical reactions and pathways resulting in the breakdown of glucose, the aldohexose gluco-hexose. RBO_relaxed.owl GO:0006026 biolink:NamedThing aminoglycan catabolic process The chemical reactions and pathways resulting in the breakdown of aminoglycans, any polymer containing amino groups that consists of more than about 10 monosaccharide residues joined to each other by glycosidic linkages. RBO_relaxed.owl GO:0006027 biolink:NamedThing glycosaminoglycan catabolic process The chemical reactions and pathways resulting in the breakdown of glycosaminoglycans, any one of a group of polysaccharides that contain amino sugars. RBO_relaxed.owl GO:0006308 biolink:NamedThing DNA catabolic process The cellular DNA metabolic process resulting in the breakdown of DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long unbranched macromolecule formed from one or two strands of linked deoxyribonucleotides, the 3'-phosphate group of each constituent deoxyribonucleotide being joined in 3',5'-phosphodiester linkage to the 5'-hydroxyl group of the deoxyribose moiety of the next one. RBO_relaxed.owl GO:0006401 biolink:NamedThing RNA catabolic process The chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. RBO_relaxed.owl GO:0006516 biolink:NamedThing glycoprotein catabolic process The chemical reactions and pathways resulting in the breakdown of a glycoprotein, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide. RBO_relaxed.owl GO:0006581 biolink:NamedThing acetylcholine catabolic process The chemical reactions and pathways resulting in the breakdown of acetylcholine, the acetic acid ester of the organic base choline. RBO_relaxed.owl GO:0006706 biolink:NamedThing steroid catabolic process The chemical reactions and pathways resulting in the breakdown of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus. RBO_relaxed.owl GO:0009057 biolink:NamedThing macromolecule catabolic process The chemical reactions and pathways resulting in the breakdown of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. RBO_relaxed.owl GO:0009063 biolink:NamedThing amino acid catabolic process The chemical reactions and pathways resulting in the breakdown of amino acids, organic acids containing one or more amino substituents. RBO_relaxed.owl GO:0009251 biolink:NamedThing glucan catabolic process The chemical reactions and pathways resulting in the breakdown of glucans, polysaccharides consisting only of glucose residues. RBO_relaxed.owl GO:0009310 biolink:NamedThing amine catabolic process The chemical reactions and pathways resulting in the breakdown of any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom. RBO_relaxed.owl GO:0009822 biolink:NamedThing alkaloid catabolic process The chemical reactions and pathways resulting in the breakdown of alkaloids, nitrogen containing natural products not otherwise classified as peptides, nonprotein amino acids, amines, cyanogenic glycosides, glucosinolates, cofactors, phytohormones or primary metabolites (such as purine or pyrimidine bases). RBO_relaxed.owl GO:0016042 biolink:NamedThing lipid catabolic process The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. RBO_relaxed.owl GO:0016052 biolink:NamedThing carbohydrate catabolic process The chemical reactions and pathways resulting in the breakdown of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. RBO_relaxed.owl GO:0016054 biolink:NamedThing organic acid catabolic process The chemical reactions and pathways resulting in the breakdown of organic acids, any acidic compound containing carbon in covalent linkage. RBO_relaxed.owl GO:0019320 biolink:NamedThing hexose catabolic process The chemical reactions and pathways resulting in the breakdown of hexose, any monosaccharide with a chain of six carbon atoms in the molecule. RBO_relaxed.owl GO:0019336 biolink:NamedThing phenol-containing compound catabolic process The chemical reactions and pathways resulting in the breakdown of a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring. RBO_relaxed.owl GO:0019439 biolink:NamedThing aromatic compound catabolic process The chemical reactions and pathways resulting in the breakdown of aromatic compounds, any substance containing an aromatic carbon ring. RBO_relaxed.owl GO:0019614 biolink:NamedThing catechol-containing compound catabolic process The chemical reactions and pathways resulting in the breakdown of catechol-containing compounds. Catechol is a compound containing a pyrocatechol nucleus or substituent. RBO_relaxed.owl GO:0030163 biolink:NamedThing protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. RBO_relaxed.owl GO:0030214 biolink:NamedThing hyaluronan catabolic process The chemical reactions and pathways resulting in the breakdown of hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine. RBO_relaxed.owl GO:0030573 biolink:NamedThing bile acid catabolic process The chemical reactions and pathways resulting in the breakdown of bile acids, any of a group of steroid carboxylic acids occurring in bile. RBO_relaxed.owl GO:0030574 biolink:NamedThing collagen catabolic process The proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix, usually carried out by proteases secreted by nearby cells. RBO_relaxed.owl GO:0033015 biolink:NamedThing tetrapyrrole catabolic process The chemical reactions and pathways leading to the breakdown of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next. RBO_relaxed.owl GO:0034655 biolink:NamedThing nucleobase-containing compound catabolic process The chemical reactions and pathways resulting in the breakdown of nucleobases, nucleosides, nucleotides and nucleic acids. RBO_relaxed.owl GO:0042182 biolink:NamedThing ketone catabolic process The chemical reactions and pathways resulting in the breakdown of ketones, a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups. RBO_relaxed.owl GO:0042422 biolink:NamedThing norepinephrine catabolic process The chemical reactions and pathways resulting in the breakdown of norepinephrine, a hormone secreted by the adrenal medulla, and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts in the central nervous system. It is also the demethylated biosynthetic precursor of epinephrine. RBO_relaxed.owl GO:0042424 biolink:NamedThing catecholamine catabolic process The chemical reactions and pathways resulting in the breakdown of any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine. RBO_relaxed.owl GO:0042429 biolink:NamedThing serotonin catabolic process The chemical reactions and pathways resulting in the breakdown of serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties. RBO_relaxed.owl GO:0042436 biolink:NamedThing indole-containing compound catabolic process The chemical reactions and pathways resulting in the breakdown of compounds that contain an indole (2,3-benzopyrrole) skeleton. RBO_relaxed.owl GO:0043171 biolink:NamedThing peptide catabolic process The chemical reactions and pathways resulting in the breakdown of peptides, compounds of 2 or more (but usually less than 100) amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another. RBO_relaxed.owl GO:0043605 biolink:NamedThing amide catabolic process The chemical reactions and pathways resulting in the breakdown of an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group. RBO_relaxed.owl GO:0043649 biolink:NamedThing dicarboxylic acid catabolic process The chemical reactions and pathways resulting in the breakdown of dicarboxylic acids, any organic acid containing two carboxyl (-COOH) groups. RBO_relaxed.owl GO:0044248 biolink:NamedThing cellular catabolic process The chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells. RBO_relaxed.owl GO:0044273 biolink:NamedThing sulfur compound catabolic process The chemical reactions and pathways resulting in the breakdown of compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione. RBO_relaxed.owl GO:0044282 biolink:NamedThing small molecule catabolic process The chemical reactions and pathways resulting in the breakdown of small molecules, any low molecular weight, monomeric, non-encoded molecule. RBO_relaxed.owl GO:0045733 biolink:NamedThing acetate catabolic process The chemical reactions and pathways resulting in the breakdown of acetate, the anion of acetic acid. RBO_relaxed.owl GO:0046113 biolink:NamedThing nucleobase catabolic process The chemical reactions and pathways resulting in the breakdown of a nucleobase, a nitrogenous base that is a constituent of a nucleic acid. RBO_relaxed.owl GO:0046365 biolink:NamedThing monosaccharide catabolic process The chemical reactions and pathways resulting in the breakdown of monosaccharides, polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms. RBO_relaxed.owl GO:0046395 biolink:NamedThing carboxylic acid catabolic process The chemical reactions and pathways resulting in the breakdown of carboxylic acids, any organic acid containing one or more carboxyl (-COOH) groups. RBO_relaxed.owl GO:0046700 biolink:NamedThing heterocycle catabolic process The chemical reactions and pathways resulting in the breakdown of heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings). RBO_relaxed.owl GO:0072329 biolink:NamedThing monocarboxylic acid catabolic process The chemical reactions and pathways resulting in the breakdown of monocarboxylic acids, any organic acid containing one carboxyl (-COOH) group. RBO_relaxed.owl GO:0099546 biolink:NamedThing protein catabolic process, modulating synaptic transmission Any protein degradation process, occurring at a presynapse, that regulates synaptic transmission. RBO_relaxed.owl GO:0140246 biolink:NamedThing protein catabolic process at synapse The chemical reactions and pathways resulting in the breakdown of a protein at a synapse. RBO_relaxed.owl GO:0140247 biolink:NamedThing protein catabolic process at presynapse The chemical reactions and pathways resulting in the breakdown of a protein at a presynapse. RBO_relaxed.owl GO:0140249 biolink:NamedThing protein catabolic process at postsynapse The chemical reactions and pathways resulting in the breakdown of a protein at a postsynapse. RBO_relaxed.owl GO:1901136 biolink:NamedThing carbohydrate derivative catabolic process The chemical reactions and pathways resulting in the breakdown of carbohydrate derivative. RBO_relaxed.owl GO:1901143 biolink:NamedThing insulin catabolic process The chemical reactions and pathways resulting in the breakdown of insulin. RBO_relaxed.owl GO:1901161 biolink:NamedThing primary amino compound catabolic process The chemical reactions and pathways resulting in the breakdown of primary amino compound. RBO_relaxed.owl GO:1901361 biolink:NamedThing organic cyclic compound catabolic process The chemical reactions and pathways resulting in the breakdown of organic cyclic compound. RBO_relaxed.owl GO:1901565 biolink:NamedThing organonitrogen compound catabolic process The chemical reactions and pathways resulting in the breakdown of organonitrogen compound. RBO_relaxed.owl GO:1901575 biolink:NamedThing organic substance catabolic process The chemical reactions and pathways resulting in the breakdown of an organic substance, any molecular entity containing carbon. RBO_relaxed.owl GO:1901606 biolink:NamedThing alpha-amino acid catabolic process The chemical reactions and pathways resulting in the breakdown of an alpha-amino acid. RBO_relaxed.owl GO:1901616 biolink:NamedThing organic hydroxy compound catabolic process The chemical reactions and pathways resulting in the breakdown of organic hydroxy compound. RBO_relaxed.owl GO:0000278 biolink:NamedThing mitotic cell cycle Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent. RBO_relaxed.owl GO:0007049 biolink:NamedThing cell cycle The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division. RBO_relaxed.owl GO:0051321 biolink:NamedThing meiotic cell cycle Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions. RBO_relaxed.owl GO:0000280 biolink:NamedThing nuclear division The division of a cell nucleus into two nuclei, with DNA and other nuclear contents distributed between the daughter nuclei. RBO_relaxed.owl GO:0048285 biolink:NamedThing organelle fission The creation of two or more organelles by division of one organelle. RBO_relaxed.owl GO:0140572 biolink:NamedThing vacuole fission The division of a vacuole within a cell to form two or more separate vacuoles. RBO_relaxed.owl GO:0000313 biolink:NamedThing organellar ribosome A ribosome contained within a subcellular membrane-bounded organelle. RBO_relaxed.owl GO:0000740 biolink:NamedThing nuclear membrane fusion The joining of 2 or more lipid bilayer membranes that surround the nucleus. RBO_relaxed.owl GO:0061025 biolink:NamedThing membrane fusion The membrane organization process that joins two lipid bilayers to form a single membrane. RBO_relaxed.owl GO:0036504 biolink:NamedThing Golgi membrane fusion The joining of two lipid bilayers that surround the Golgi apparatus to form a single Golgi membrane. RBO_relaxed.owl GO:0045026 biolink:NamedThing plasma membrane fusion The joining of the lipid bilayer membrane that surround a cell with that of another cell, producing a single cell. RBO_relaxed.owl GO:0090174 biolink:NamedThing organelle membrane fusion The joining of two lipid bilayers to form a single organelle membrane. RBO_relaxed.owl GO:0099500 biolink:NamedThing vesicle fusion to plasma membrane Fusion of the membrane of a vesicle with the plasma membrane, thereby releasing its contents into the extracellular space. RBO_relaxed.owl GO:0030264 biolink:NamedThing nuclear fragmentation involved in apoptotic nuclear change The breakdown of the nucleus into small membrane-bounded compartments, or blebs, each of which contain compacted DNA. RBO_relaxed.owl GO:0051081 biolink:NamedThing nuclear membrane disassembly The controlled breakdown of the nuclear membranes, for example during cellular division. RBO_relaxed.owl GO:0006906 biolink:NamedThing vesicle fusion Fusion of the membrane of a transport vesicle with its target membrane. RBO_relaxed.owl GO:0000741 biolink:NamedThing karyogamy The creation of a single nucleus from multiple nuclei as a result of fusing the lipid bilayers that surround each nuclei. RBO_relaxed.owl GO:1905690 biolink:NamedThing nucleus disassembly The disaggregation of a nucleus into its constituent components. RBO_relaxed.owl GO:0048284 biolink:NamedThing organelle fusion The creation of a single organelle from two or more organelles. RBO_relaxed.owl GO:0000768 biolink:NamedThing syncytium formation by plasma membrane fusion The formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells. RBO_relaxed.owl GO:0006949 biolink:NamedThing syncytium formation The formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane. Syncytia are normally derived from single cells that fuse or fail to complete cell division. RBO_relaxed.owl GO:0140253 biolink:NamedThing cell-cell fusion A cellular process in which two or more cells combine together, their plasma membrane fusing, producing a single cell. In some cases, nuclei fuse, producing a polyploid cell, while in other cases, nuclei remain separate, producing a syncytium. RBO_relaxed.owl GO:0000785 biolink:NamedThing chromatin The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome. RBO_relaxed.owl GO:0032993 biolink:NamedThing protein-DNA complex A macromolecular complex containing both protein and DNA molecules. RBO_relaxed.owl GO:0000792 biolink:NamedThing heterochromatin A compact and highly condensed form of chromatin that is refractory to transcription. RBO_relaxed.owl GO:0030261 biolink:NamedThing chromosome condensation The progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells. RBO_relaxed.owl GO:0070192 biolink:NamedThing chromosome organization involved in meiotic cell cycle A process of chromosome organization that is involved in a meiotic cell cycle. RBO_relaxed.owl GO:0000902 biolink:NamedThing cell morphogenesis The developmental process in which the size or shape of a cell is generated and organized. RBO_relaxed.owl GO:0009653 biolink:NamedThing anatomical structure morphogenesis The process in which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form. RBO_relaxed.owl GO:0001745 biolink:NamedThing compound eye morphogenesis The morphogenetic process in which the anatomical structures of the compound eye are generated and organized. The adult compound eye is a precise assembly of 700-800 ommatidia. Each ommatidium is composed of 20 cells, identified by cell type and position. An example of compound eye morphogenesis is found in Drosophila melanogaster. RBO_relaxed.owl GO:0001763 biolink:NamedThing morphogenesis of a branching structure The process in which the anatomical structures of branches are generated and organized. A branch is a division or offshoot from a main stem. Examples in animals would include blood vessels, nerves, lymphatics and other endothelial or epithelial tubes. RBO_relaxed.owl GO:0001831 biolink:NamedThing trophectodermal cellular morphogenesis The morphogenesis of trophectoderm cells. RBO_relaxed.owl GO:0001839 biolink:NamedThing neural plate morphogenesis The process in which the anatomical structures of the neural plate are generated and organized. The neural plate is a specialized region of columnar epithelial cells in the dorsal ectoderm that will give rise to nervous system tissue. RBO_relaxed.owl GO:0001886 biolink:NamedThing endothelial cell morphogenesis The change in form (cell shape and size) that occurs during the differentiation of an endothelial cell. RBO_relaxed.owl GO:0002009 biolink:NamedThing morphogenesis of an epithelium The process in which the anatomical structures of epithelia are generated and organized. An epithelium consists of closely packed cells arranged in one or more layers, that covers the outer surfaces of the body or lines any internal cavity or tube. RBO_relaxed.owl GO:0002011 biolink:NamedThing morphogenesis of an epithelial sheet The process in which the anatomical structures of an epithelial sheet are generated and organized. An epithelial sheet is a flat surface consisting of closely packed epithelial cells. RBO_relaxed.owl GO:0002072 biolink:NamedThing optic cup morphogenesis involved in camera-type eye development The invagination of the optic vesicle to form two-walled indentations, the optic cups, that will go on to form the retina. This process begins with the optic vesicle becoming a two-walled structure and its subsequent shape changes. It does not include the fate commitment of cells to become the pigmented retina and the neural retina. An example of this process is found in Mus musculus. RBO_relaxed.owl GO:0002089 biolink:NamedThing lens morphogenesis in camera-type eye The process in which the anatomical structures of the lens are generated and organized. The lens is a transparent structure in the eye through which light is focused onto the retina. An example of this process is found in Mus musculus. RBO_relaxed.owl GO:0003007 biolink:NamedThing heart morphogenesis The developmental process in which the heart is generated and organized. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. RBO_relaxed.owl GO:0003142 biolink:NamedThing cardiogenic plate morphogenesis The process in which the anatomical structures of the cardiogenic plate are generated and organized. The cardiogenic plate is the first recognizable structure derived from the heart field. RBO_relaxed.owl GO:0003143 biolink:NamedThing embryonic heart tube morphogenesis The process in which the anatomical structures of the embryonic heart tube are generated and organized. The embryonic heart tube is an epithelial tube that will give rise to the mature heart. RBO_relaxed.owl GO:0003148 biolink:NamedThing outflow tract septum morphogenesis The process in which the anatomical structures of the outflow tract septum are generated and organized. The outflow tract septum is a partition in the outflow tract. RBO_relaxed.owl GO:0003149 biolink:NamedThing membranous septum morphogenesis The process in which the membranous septum is generated and organized. The membranous septum is the upper part of ventricular septum. RBO_relaxed.owl GO:0003150 biolink:NamedThing muscular septum morphogenesis The process in which the muscular septum is generated and organized. The muscular septum is the lower part of the ventricular septum. RBO_relaxed.owl GO:0003151 biolink:NamedThing outflow tract morphogenesis The process in which the anatomical structures of the outflow tract are generated and organized. The outflow tract is the portion of the heart through which blood flows into the arteries. RBO_relaxed.owl GO:0003159 biolink:NamedThing morphogenesis of an endothelium The process in which the anatomical structure of an endothelium is generated and organized. Endothelium refers to the layer of cells lining blood vessels, lymphatics, the heart, and serous cavities, and is derived from bone marrow or mesoderm. Corneal endothelium is a special case, derived from neural crest cells. RBO_relaxed.owl GO:0003160 biolink:NamedThing endocardium morphogenesis The process in which the anatomical structure of the endocardium is generated and organized. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers. RBO_relaxed.owl GO:0003169 biolink:NamedThing coronary vein morphogenesis The process in which the anatomical structures of veins of the heart are generated and organized. RBO_relaxed.owl GO:0003203 biolink:NamedThing endocardial cushion morphogenesis The process in which the anatomical structure of the endocardial cushion is generated and organized. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves. RBO_relaxed.owl GO:0003206 biolink:NamedThing cardiac chamber morphogenesis The process in which a cardiac chamber is generated and organized. A cardiac chamber is an enclosed cavity within the heart. RBO_relaxed.owl GO:0003208 biolink:NamedThing cardiac ventricle morphogenesis The process in which the cardiac ventricle is generated and organized. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart. RBO_relaxed.owl GO:0003209 biolink:NamedThing cardiac atrium morphogenesis The process in which the cardiac atrium is generated and organized. A cardiac atrium receives blood from a vein and pumps it to a cardiac ventricle. RBO_relaxed.owl GO:0003212 biolink:NamedThing cardiac left atrium morphogenesis The process in which the left cardiac atrium is generated and organized. RBO_relaxed.owl GO:0003213 biolink:NamedThing cardiac right atrium morphogenesis The process in which the right cardiac atrium is generated and organized. RBO_relaxed.owl GO:0003214 biolink:NamedThing cardiac left ventricle morphogenesis The process in which the left cardiac ventricle is generated and organized. RBO_relaxed.owl GO:0003215 biolink:NamedThing cardiac right ventricle morphogenesis The process in which the right cardiac ventricle is generated and organized. RBO_relaxed.owl GO:0003220 biolink:NamedThing left ventricular cardiac muscle tissue morphogenesis The process in which the anatomical structures of left cardiac ventricle muscle are generated and organized. RBO_relaxed.owl GO:0003221 biolink:NamedThing right ventricular cardiac muscle tissue morphogenesis The process in which the anatomical structures of the right cardiac ventricle muscle are generated and organized. RBO_relaxed.owl GO:0003222 biolink:NamedThing ventricular trabecula myocardium morphogenesis The process in which the anatomical structures of the trabecular cardiac ventricle muscle are generated and organized. RBO_relaxed.owl GO:0003225 biolink:NamedThing left ventricular trabecular myocardium morphogenesis The process in which the anatomical structures of cardiac left ventricular trabecular myocardium are generated and organized. RBO_relaxed.owl GO:0003227 biolink:NamedThing right ventricular trabecular myocardium morphogenesis The process in which the anatomical structures of the right ventricular myocardium are generated and organized. RBO_relaxed.owl GO:0003236 biolink:NamedThing sinus venosus morphogenesis The process in which the sinus venosus is generated and organized. The sinus venosus is a heart chamber attached to the atrium on the venous side of the embryonic heart. RBO_relaxed.owl GO:0003314 biolink:NamedThing heart rudiment morphogenesis The process in which the anatomical structures of the heart rudiment are generated and organized. RBO_relaxed.owl GO:0003344 biolink:NamedThing pericardium morphogenesis The process in which the anatomical structure of the pericardium is generated and organized. RBO_relaxed.owl GO:0003382 biolink:NamedThing epithelial cell morphogenesis The change in form that occurs when an epithelial cell progresses from its initial formation to its mature state. RBO_relaxed.owl GO:0003404 biolink:NamedThing optic vesicle morphogenesis The developmental process pertaining to the formation and shaping of the optic vesicle. This process begins with the specific processes that contribute to the appearance of the vesicle and ends when the vesicle has evaginated. The optic vesicle is the evagination of neurectoderm that precedes formation of the optic cup. RBO_relaxed.owl GO:0007439 biolink:NamedThing ectodermal digestive tract development The process whose specific outcome is the progression of the ectodermal digestive tract over time, from its formation to the mature structure. The ectodermal digestive tract includes those portions that are derived from ectoderm. RBO_relaxed.owl GO:0007440 biolink:NamedThing foregut morphogenesis The process in which the anatomical structures of the foregut are generated and organized. RBO_relaxed.owl GO:0007442 biolink:NamedThing hindgut morphogenesis The process in which the anatomical structures of the hindgut are generated and organized. RBO_relaxed.owl GO:0008594 biolink:NamedThing photoreceptor cell morphogenesis The process in which the structures of a photoreceptor cell are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a photoreceptor cell, a sensory cell that reacts to the presence of light. An example of this is found in Drosophila melanogaster. RBO_relaxed.owl GO:0009887 biolink:NamedThing animal organ morphogenesis Morphogenesis of an animal organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions. RBO_relaxed.owl GO:0010171 biolink:NamedThing body morphogenesis The process in which the anatomical structures of the soma are generated and organized. RBO_relaxed.owl GO:0021551 biolink:NamedThing central nervous system morphogenesis The process in which the anatomical structure of the central nervous system is generated and organized. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord. RBO_relaxed.owl GO:0021555 biolink:NamedThing midbrain-hindbrain boundary morphogenesis The process in which the anatomical structure of the midbrain-hindbrain boundary is generated and organized. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate. RBO_relaxed.owl GO:0021575 biolink:NamedThing hindbrain morphogenesis The process in which the anatomical structure of the hindbrain is generated and organized. The hindbrain is the region consisting of the medulla, pons and cerebellum. Areas of the hindbrain control motor and autonomic functions. RBO_relaxed.owl GO:0021579 biolink:NamedThing medulla oblongata morphogenesis The process in which the anatomical structure of the medulla oblongata is generated and organized. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate. RBO_relaxed.owl GO:0021583 biolink:NamedThing pons morphogenesis The process in which the anatomical structure of the pons is generated and organized. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum. RBO_relaxed.owl GO:0021593 biolink:NamedThing rhombomere morphogenesis The process in which the anatomical structure of the rhombomere is generated and organized. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. RBO_relaxed.owl GO:0021602 biolink:NamedThing cranial nerve morphogenesis The process in which the anatomical structure of the cranial nerves are generated and organized. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions. RBO_relaxed.owl GO:0021636 biolink:NamedThing trigeminal nerve morphogenesis The process in which the anatomical structure of the trigeminal nerve is generated and organized. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae. RBO_relaxed.owl GO:0021704 biolink:NamedThing locus ceruleus morphogenesis The process in which the anatomical structure of the locus ceruleus is generated and organized. In mice, the locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic. RBO_relaxed.owl GO:0021719 biolink:NamedThing superior olivary nucleus morphogenesis The process in which the anatomical structure of the superior olivary nucleus is generated and organized. In mice, the superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound. RBO_relaxed.owl GO:0022612 biolink:NamedThing gland morphogenesis The process in which the anatomical structures of a gland are generated and organized. RBO_relaxed.owl GO:0032989 biolink:NamedThing cellular anatomical entity morphogenesis The process in which a cellular entity is generated and organized. A cellular entity has granularity above the level of a protein complex but below that of an anatomical system. RBO_relaxed.owl GO:0035107 biolink:NamedThing appendage morphogenesis The process in which the anatomical structures of appendages are generated and organized. An appendage is an organ or part that is attached to the trunk of an organism, such as a limb or a branch. RBO_relaxed.owl GO:0035112 biolink:NamedThing genitalia morphogenesis The process in which the anatomical structures of genitalia are generated and organized. The genitalia are the organs of reproduction or generation, external and internal. RBO_relaxed.owl GO:0035239 biolink:NamedThing tube morphogenesis The process in which the anatomical structures of a tube are generated and organized. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system. RBO_relaxed.owl GO:0035260 biolink:NamedThing internal genitalia morphogenesis The process in which the anatomical structures of the internal genitalia are generated and organized. The internal genitalia are the internal sex organs such as the uterine tube, the uterus and the vagina in female mammals, and the testis, seminal vesicle, ejaculatory duct and prostate in male mammals. RBO_relaxed.owl GO:0035261 biolink:NamedThing external genitalia morphogenesis The process in which the anatomical structures of the external genitalia are generated and organized. The external genitalia are the outer sex organs, such as the penis or vulva in mammals. RBO_relaxed.owl GO:0035262 biolink:NamedThing gonad morphogenesis The process in which the anatomical structures of the gonads are generated and organized. A gonad is an animal organ producing gametes, e.g. the testes or the ovary in mammals. RBO_relaxed.owl GO:0035909 biolink:NamedThing aorta morphogenesis The process in which the anatomical structures of an aorta are generated and organized. An aorta is an artery that carries blood from the heart to other parts of the body. RBO_relaxed.owl GO:0035910 biolink:NamedThing ascending aorta morphogenesis The process in which the anatomical structures of the ascending aorta are generated and organized. The ascending aorta is the portion of the aorta in a two-pass circulatory system that lies between the heart and the arch of aorta. In a two-pass circulatory system blood passes twice through the heart to supply the body once. RBO_relaxed.owl GO:0035911 biolink:NamedThing descending aorta morphogenesis The process in which the anatomical structures of the descending aorta are generated and organized. The descending aorta is the portion of the aorta in a two-pass circulatory system from the arch of aorta to the point where it divides into the common iliac arteries. In a two-pass circulatory system blood passes twice through the heart to supply the body once. RBO_relaxed.owl GO:0035912 biolink:NamedThing dorsal aorta morphogenesis The process in which the anatomical structures of the dorsal aorta are generated and organized. The dorsal aorta is a blood vessel in a single-pass circulatory system that carries oxygenated blood from the gills to the rest of the body. In a single-pass circulatory system blood passes once through the heart to supply the body once. RBO_relaxed.owl GO:0036342 biolink:NamedThing post-anal tail morphogenesis The process in which a post-anal tail is generated and organized. A post-anal tail is a muscular region of the body that extends posterior to the anus. The post-anal tail may aid locomotion and balance. RBO_relaxed.owl GO:0043589 biolink:NamedThing skin morphogenesis The process in which the anatomical structures of the skin are generated and organized. The skin is the external membranous integument of an animal. In vertebrates the skin generally consists of two layers, an outer nonsensitive and nonvascular epidermis (cuticle or skarfskin) composed of cells which are constantly growing and multiplying in the deeper, and being thrown off in the superficial layers, as well as an inner, sensitive and vascular dermis (cutis, corium or true skin) composed mostly of connective tissue. RBO_relaxed.owl GO:0048319 biolink:NamedThing axial mesoderm morphogenesis The process in which the anatomical structures of the axial mesoderm are generated and organized. RBO_relaxed.owl GO:0048332 biolink:NamedThing mesoderm morphogenesis The process in which the anatomical structures of the mesoderm are generated and organized. RBO_relaxed.owl GO:0048340 biolink:NamedThing paraxial mesoderm morphogenesis The process in which the anatomical structures of the paraxial mesoderm are generated and organized. RBO_relaxed.owl GO:0048369 biolink:NamedThing lateral mesoderm morphogenesis The process in which the anatomical structures of the lateral mesoderm are generated and organized. RBO_relaxed.owl GO:0048390 biolink:NamedThing intermediate mesoderm morphogenesis The process in which the anatomical structures of the intermediate mesoderm are generated and organized. RBO_relaxed.owl GO:0048514 biolink:NamedThing blood vessel morphogenesis The process in which the anatomical structures of blood vessels are generated and organized. The blood vessel is the vasculature carrying blood. RBO_relaxed.owl GO:0048546 biolink:NamedThing digestive tract morphogenesis The process in which the anatomical structures of the digestive tract are generated and organized. The digestive tract is the anatomical structure through which food passes and is processed. RBO_relaxed.owl GO:0048570 biolink:NamedThing notochord morphogenesis The process in which the anatomical structures of the notochord are generated and organized. The notochord is a mesoderm-derived structure located ventral of the developing nerve cord. In vertebrates, the notochord serves as a core around which other mesodermal cells form the vertebrae. In the most primitive chordates, which lack vertebrae, the notochord persists as a substitute for a vertebral column. RBO_relaxed.owl GO:0048592 biolink:NamedThing eye morphogenesis The process in which the anatomical structures of the eye are generated and organized. RBO_relaxed.owl GO:0048593 biolink:NamedThing camera-type eye morphogenesis The process in which the anatomical structures of the eye are generated and organized. The camera-type eye is an organ of sight that receives light through an aperture and focuses it through a lens, projecting it on a photoreceptor field. RBO_relaxed.owl GO:0048598 biolink:NamedThing embryonic morphogenesis The process in which anatomical structures are generated and organized during the embryonic phase. The embryonic phase begins with zygote formation. The end of the embryonic phase is organism-specific. For example, it would be at birth for mammals, larval hatching for insects and seed dormancy in plants. RBO_relaxed.owl GO:0048601 biolink:NamedThing oocyte morphogenesis The process in which the structures of an oocyte are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of an oocyte. RBO_relaxed.owl GO:0048644 biolink:NamedThing muscle organ morphogenesis The process in which the anatomical structures of muscle are generated and organized. RBO_relaxed.owl GO:0048705 biolink:NamedThing skeletal system morphogenesis The process in which the anatomical structures of the skeleton are generated and organized. RBO_relaxed.owl GO:0048729 biolink:NamedThing tissue morphogenesis The process in which the anatomical structures of a tissue are generated and organized. RBO_relaxed.owl GO:0048730 biolink:NamedThing epidermis morphogenesis The process in which the anatomical structures of the epidermis are generated and organized. The epidermis is the outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species. RBO_relaxed.owl GO:0048812 biolink:NamedThing neuron projection morphogenesis The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites. RBO_relaxed.owl GO:0048844 biolink:NamedThing artery morphogenesis The process in which the anatomical structures of arterial blood vessels are generated and organized. Arteries are blood vessels that transport blood from the heart to the body and its organs. RBO_relaxed.owl GO:0048845 biolink:NamedThing venous blood vessel morphogenesis The process in which the anatomical structures of venous blood vessels are generated and organized. Veins are blood vessels that transport blood from the body and its organs to the heart. RBO_relaxed.owl GO:0048854 biolink:NamedThing brain morphogenesis The process in which the anatomical structures of the brain are generated and organized. The brain is one of the two components of the central nervous system and is the center of thought and emotion. It is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.). RBO_relaxed.owl GO:0048858 biolink:NamedThing cell projection morphogenesis The process in which the anatomical structures of a cell projection are generated and organized. RBO_relaxed.owl GO:0055008 biolink:NamedThing cardiac muscle tissue morphogenesis The process in which the anatomical structures of cardiac muscle tissue are generated and organized. RBO_relaxed.owl GO:0055009 biolink:NamedThing atrial cardiac muscle tissue morphogenesis The process in which the anatomical structure of cardiac atrium muscle is generated and organized. RBO_relaxed.owl GO:0055010 biolink:NamedThing ventricular cardiac muscle tissue morphogenesis The process in which the anatomical structures of cardiac ventricle muscle is generated and organized. RBO_relaxed.owl GO:0060042 biolink:NamedThing retina morphogenesis in camera-type eye The process in which the anatomical structure of the retina is generated and organized. RBO_relaxed.owl GO:0060323 biolink:NamedThing head morphogenesis The process in which the anatomical structures of the head are generated and organized. The head is the anterior-most division of the body. RBO_relaxed.owl GO:0060325 biolink:NamedThing face morphogenesis The process in which the anatomical structures of the face are generated and organized. The face is the ventral division of the head. RBO_relaxed.owl GO:0060349 biolink:NamedThing bone morphogenesis The process in which bones are generated and organized. RBO_relaxed.owl GO:0060411 biolink:NamedThing cardiac septum morphogenesis The process in which the anatomical structure of a cardiac septum is generated and organized. A cardiac septum is a partition that separates parts of the heart. RBO_relaxed.owl GO:0060412 biolink:NamedThing ventricular septum morphogenesis The developmental process in which a ventricular septum is generated and organized. A ventricular septum is an anatomical structure that separates the lower chambers (ventricles) of the heart from one another. RBO_relaxed.owl GO:0060413 biolink:NamedThing atrial septum morphogenesis The developmental process in which atrial septum is generated and organized. The atrial septum separates the upper chambers (the atria) of the heart from one another. RBO_relaxed.owl GO:0060414 biolink:NamedThing aorta smooth muscle tissue morphogenesis The process in which the structure of the smooth muscle tissue surrounding the aorta is generated and organized. An aorta is an artery that carries blood from the heart to other parts of the body. RBO_relaxed.owl GO:0060425 biolink:NamedThing lung morphogenesis The process in which the anatomical structures of the lung are generated and organized. RBO_relaxed.owl GO:0060439 biolink:NamedThing trachea morphogenesis The process in which a trachea is generated and organized. The trachea is the portion of the airway that attaches to the bronchi as it branches. RBO_relaxed.owl GO:0060460 biolink:NamedThing left lung morphogenesis The process in which anatomical structures of the left lung are generated and organized. RBO_relaxed.owl GO:0060461 biolink:NamedThing right lung morphogenesis The process in which anatomical structures of the right lung are generated and organized. RBO_relaxed.owl GO:0060463 biolink:NamedThing lung lobe morphogenesis The process in which the anatomical structures of a lung lobe are generated and organized. A lung lobe is a projection that extends from the lung. RBO_relaxed.owl GO:0060536 biolink:NamedThing cartilage morphogenesis The process in which the anatomical structures of cartilage are generated and organized. RBO_relaxed.owl GO:0060540 biolink:NamedThing diaphragm morphogenesis The process in which the anatomical structures of the diaphragm are generated and organized. RBO_relaxed.owl GO:0060562 biolink:NamedThing epithelial tube morphogenesis The process in which the anatomical structures of a tube are generated and organized from an epithelium. Epithelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system. RBO_relaxed.owl GO:0060571 biolink:NamedThing morphogenesis of an epithelial fold The morphogenetic process in which an epithelial sheet bends along a linear axis. RBO_relaxed.owl GO:0060572 biolink:NamedThing morphogenesis of an epithelial bud The morphogenetic process in which a bud forms from an epithelial sheet. A bud is a protrusion that forms form the sheet by localized folding. RBO_relaxed.owl GO:0060577 biolink:NamedThing pulmonary vein morphogenesis The process in which the anatomical structure of the pulmonary venous blood vessels are generated and organized. Pulmonary veins are blood vessels that transport blood from the lungs to the heart. RBO_relaxed.owl GO:0060578 biolink:NamedThing superior vena cava morphogenesis The process in which the anatomical structure of superior vena cava generated and organized. The superior vena cava is a blood vessel that transports blood from the upper body to the heart. RBO_relaxed.owl GO:0060977 biolink:NamedThing coronary vasculature morphogenesis The process in which the anatomical structures of blood vessels of the heart are generated and organized. The blood vessel is the vasculature carrying blood. RBO_relaxed.owl GO:0061040 biolink:NamedThing female gonad morphogenesis The process in which a female gonad is generated and organized. RBO_relaxed.owl GO:0061072 biolink:NamedThing iris morphogenesis The process in which the iris is generated and organized. The iris is an anatomical structure in the eye whose opening forms the pupil. The iris is responsible for controlling the diameter and size of the pupil and the amount of light reaching the retina. RBO_relaxed.owl GO:0061073 biolink:NamedThing ciliary body morphogenesis The process in which the ciliary body generated and organized. The ciliary body is the circumferential tissue inside the eye composed of the ciliary muscle and ciliary processes. RBO_relaxed.owl GO:0061113 biolink:NamedThing pancreas morphogenesis Morphogenesis of the pancreas. Morphogenesis is the process in which anatomical structures are generated and organized. RBO_relaxed.owl GO:0061154 biolink:NamedThing endothelial tube morphogenesis The process in which the anatomical structures of a tube are generated and organized from an endothelium. Endothelium refers to the layer of cells lining blood vessels, lymphatics, the heart, and serous cavities, and is derived from bone marrow or mesoderm. Corneal endothelium is a special case, derived from neural crest cells. RBO_relaxed.owl GO:0061155 biolink:NamedThing pulmonary artery endothelial tube morphogenesis The process in which the anatomical structures of a tube are generated and organized from the pulmonary artery endothelium. An pulmonary artery endothelium is an epithelium that lines the pulmonary artery. RBO_relaxed.owl GO:0061156 biolink:NamedThing pulmonary artery morphogenesis The process in which the anatomical structures of the pulmonary artery are generated and organized. The pulmonary artery is the artery that carries blood from the heart to the lungs. RBO_relaxed.owl GO:0061299 biolink:NamedThing retina vasculature morphogenesis in camera-type eye The process in which the vasculature of the retina is generated and organized. RBO_relaxed.owl GO:0061304 biolink:NamedThing retinal blood vessel morphogenesis The process whose specific outcome is the progression of a blood vessel of the retina over time, from its formation to the mature structure. RBO_relaxed.owl GO:0061383 biolink:NamedThing trabecula morphogenesis The process of shaping a trabecula in an organ. A trabecula is a small, often microscopic, tissue element in the form of a small beam, strut or rod, which generally has a mechanical function. Trabecula are usually but not necessarily, composed of dense collagenous tissue. RBO_relaxed.owl GO:0061384 biolink:NamedThing heart trabecula morphogenesis The process of shaping a trabecula in the heart. A trabecula is a small, often microscopic, tissue element in the form of a small beam, strut or rod, which generally has a mechanical function. Trabecula are usually but not necessarily, composed of dense collagenous tissue. RBO_relaxed.owl GO:0061552 biolink:NamedThing ganglion morphogenesis The process in which the anatomical structures of ganglion are generated and organized. RBO_relaxed.owl GO:0061556 biolink:NamedThing trigeminal ganglion morphogenesis The process in which the anatomical structure of a trigeminal ganglion is generated and organized. RBO_relaxed.owl GO:0061559 biolink:NamedThing cranial ganglion morphogenesis The process in which the anatomical structure of a cranial ganglion is generated and organized. RBO_relaxed.owl GO:0061626 biolink:NamedThing pharyngeal arch artery morphogenesis The process in which the anatomical structures of a pharyngeal arch artery is generated and organized. The pharyngeal arch arteries are a series of six paired embryological vascular structures, the development of which give rise to several major arteries, such as the stapedial artery, the middle meningeal artery, the internal carotid artery and the pulmonary artery. RBO_relaxed.owl GO:0071697 biolink:NamedThing ectodermal placode morphogenesis The process in which the anatomical structures of an ectodermal placode are generated and organized. An ectodermal placode is a thickening of the ectoderm that is the primordium of many structures derived from the ectoderm. RBO_relaxed.owl GO:0072132 biolink:NamedThing mesenchyme morphogenesis The process in which the anatomical structures of a mesenchymal tissue are generated and organized. A mesenchymal tissue is made up of loosely packed stellate cells. RBO_relaxed.owl GO:0072576 biolink:NamedThing liver morphogenesis The process in which the anatomical structures of the liver are generated and organized. RBO_relaxed.owl GO:0090171 biolink:NamedThing chondrocyte morphogenesis The process in which the structures of a chondrocyte are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a chondrocyte. RBO_relaxed.owl GO:0090596 biolink:NamedThing sensory organ morphogenesis Morphogenesis of a sensory organ. A sensory organ is defined as a tissue or set of tissues that work together to receive and transmit signals from external or internal stimuli. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions. RBO_relaxed.owl GO:0120039 biolink:NamedThing plasma membrane bounded cell projection morphogenesis The process in which the anatomical structures of a plasma membrane bounded cell projection are generated and organized. RBO_relaxed.owl GO:1904693 biolink:NamedThing midbrain morphogenesis The developmental process by which a midbrain is generated and organized. RBO_relaxed.owl GO:1904770 biolink:NamedThing intramembranous bone morphogenesis The developmental process by which an intramembranous bone is generated and organized. RBO_relaxed.owl GO:1905223 biolink:NamedThing epicardium morphogenesis The developmental process by which an epicardium is generated and organized. RBO_relaxed.owl GO:0001101 biolink:NamedThing response to acid chemical Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by the chemical structure of the anion portion of a dissociated acid (rather than the acid acting as a proton donor). The acid chemical may be in gaseous, liquid or solid form. RBO_relaxed.owl GO:0042221 biolink:NamedThing response to chemical Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus. RBO_relaxed.owl GO:0009636 biolink:NamedThing response to toxic substance Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus. RBO_relaxed.owl GO:0010033 biolink:NamedThing response to organic substance Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic substance stimulus. RBO_relaxed.owl GO:0010035 biolink:NamedThing response to inorganic substance Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an inorganic substance stimulus. RBO_relaxed.owl GO:0032868 biolink:NamedThing response to insulin Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms. RBO_relaxed.owl GO:1901698 biolink:NamedThing response to nitrogen compound Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrogen compound stimulus. RBO_relaxed.owl GO:1901700 biolink:NamedThing response to oxygen-containing compound Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen-containing compound stimulus. RBO_relaxed.owl GO:1902074 biolink:NamedThing response to salt Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a salt stimulus. RBO_relaxed.owl GO:0001501 biolink:NamedThing skeletal system development The process whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure. The skeleton is the bony framework of the body in vertebrates (endoskeleton) or the hard outer envelope of insects (exoskeleton or dermoskeleton). RBO_relaxed.owl GO:0048731 biolink:NamedThing system development The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process. RBO_relaxed.owl GO:0001655 biolink:NamedThing urogenital system development The process whose specific outcome is the progression of the urogenital system over time, from its formation to the mature structure. RBO_relaxed.owl GO:0001944 biolink:NamedThing vasculature development The process whose specific outcome is the progression of the vasculature over time, from its formation to the mature structure. The vasculature is an interconnected tubular multi-tissue structure that contains fluid that is actively transported around the organism. RBO_relaxed.owl GO:0002520 biolink:NamedThing immune system development The process whose specific outcome is the progression of an organismal system whose objective is to provide calibrated responses by an organism to a potential internal or invasive threat, over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process. RBO_relaxed.owl GO:0007399 biolink:NamedThing nervous system development The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state. RBO_relaxed.owl GO:0007417 biolink:NamedThing central nervous system development The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord. RBO_relaxed.owl GO:0007422 biolink:NamedThing peripheral nervous system development The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands. RBO_relaxed.owl GO:0035270 biolink:NamedThing endocrine system development Progression of the endocrine system over time, from its formation to a mature structure. The endocrine system is a system of hormones and ductless glands, where the glands release hormones directly into the blood, lymph or other intercellular fluid, and the hormones circulate within the body to affect distant organs. The major glands that make up the human endocrine system are the hypothalamus, pituitary, thyroid, parathryoids, adrenals, pineal body, and the reproductive glands which include the ovaries and testes. RBO_relaxed.owl GO:0035272 biolink:NamedThing exocrine system development Progression of the exocrine system over time, from its formation to a mature structure. The exocrine system is a system of hormones and glands, where the glands secrete straight to a target site via ducts or tubes. The human exocrine system includes the salivary glands, sweat glands and many glands of the digestive system. RBO_relaxed.owl GO:0048483 biolink:NamedThing autonomic nervous system development The process whose specific outcome is the progression of the autonomic nervous system over time, from its formation to the mature structure. The autonomic nervous system is composed of neurons that are not under conscious control, and is comprised of two antagonistic components, the sympathetic and parasympathetic nervous systems. The autonomic nervous system regulates key functions including the activity of the cardiac (heart) muscle, smooth muscles (e.g. of the gut), and glands. RBO_relaxed.owl GO:0048485 biolink:NamedThing sympathetic nervous system development The process whose specific outcome is the progression of the sympathetic nervous system over time, from its formation to the mature structure. The sympathetic nervous system is one of the two divisions of the vertebrate autonomic nervous system (the other being the parasympathetic nervous system). The sympathetic preganglionic neurons have their cell bodies in the thoracic and lumbar regions of the spinal cord and connect to the paravertebral chain of sympathetic ganglia. Innervate heart and blood vessels, sweat glands, viscera and the adrenal medulla. Most sympathetic neurons, but not all, use noradrenaline as a post-ganglionic neurotransmitter. RBO_relaxed.owl GO:0048880 biolink:NamedThing sensory system development The process whose specific outcome is the progression of a sensory system over time from its formation to the mature structure. RBO_relaxed.owl GO:0055123 biolink:NamedThing digestive system development The process whose specific outcome is the progression of the digestive system over time, from its formation to the mature structure. The digestive system is the entire structure in which digestion takes place. Digestion is all of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism. RBO_relaxed.owl GO:0060037 biolink:NamedThing pharyngeal system development The process whose specific outcome is the progression of the pharyngeal system over time, from its formation to the mature structure. The pharyngeal system is a transient embryonic complex that is specific to vertebrates. It comprises the pharyngeal arches, bulges of tissues of mesoderm and neural crest derivation through which pass nerves and pharyngeal arch arteries. The arches are separated internally by pharyngeal pouches, evaginations of foregut endoderm, and externally by pharyngeal clefts, invaginations of surface ectoderm. The development of the system ends when the stucture it contributes to are forming: the thymus, thyroid, parathyroids, maxilla, mandible, aortic arch, cardiac outflow tract, external and middle ear. RBO_relaxed.owl GO:0060541 biolink:NamedThing respiratory system development The progression of the respiratory system over time from its formation to its mature structure. The respiratory system carries out respiratory gaseous exchange. RBO_relaxed.owl GO:0061008 biolink:NamedThing hepaticobiliary system development The progression of the hepaticobiliary system over time, from its formation to the mature structure. The hepaticobiliary system is responsible for metabolic and catabolic processing of small molecules absorbed from the blood or gut, hormones and serum proteins, detoxification, storage of glycogen, triglycerides, metals and lipid soluble vitamins and excretion of bile. Included are the synthesis of albumin, blood coagulation factors, complement, and specific binding proteins. RBO_relaxed.owl GO:0061458 biolink:NamedThing reproductive system development The progression of the reproductive system over time from its formation to the mature structure. The reproductive system consists of the organs that function in reproduction. RBO_relaxed.owl GO:0072001 biolink:NamedThing renal system development The process whose specific outcome is the progression of the renal system over time, from its formation to the mature structure. The renal system maintains fluid balance and contributes to electrolyte balance, acid/base balance, and disposal of nitrogenous waste products. In humans, the renal system comprises a pair of kidneys, a pair of ureters, urinary bladder, urethra, sphincter muscle and associated blood vessels. RBO_relaxed.owl GO:0072359 biolink:NamedThing circulatory system development The process whose specific outcome is the progression of the circulatory system over time, from its formation to the mature structure. The circulatory system is the organ system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells, etc. to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis. RBO_relaxed.owl GO:0048856 biolink:NamedThing anatomical structure development The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome. RBO_relaxed.owl GO:0001568 biolink:NamedThing blood vessel development The process whose specific outcome is the progression of a blood vessel over time, from its formation to the mature structure. The blood vessel is the vasculature carrying blood. RBO_relaxed.owl GO:0001654 biolink:NamedThing eye development The process whose specific outcome is the progression of the eye over time, from its formation to the mature structure. The eye is the organ of sight. RBO_relaxed.owl GO:0001824 biolink:NamedThing blastocyst development The process whose specific outcome is the progression of the blastocyst over time, from its formation to the mature structure. The mammalian blastocyst is a hollow ball of cells containing two cell types, the inner cell mass and the trophectoderm. RBO_relaxed.owl GO:0001840 biolink:NamedThing neural plate development The process whose specific outcome is the progression of the neural plate over time, from its formation to the mature structure. The neural plate is a flat, thickened layer of ectodermal cells. The underlying dorsal mesoderm signals the ectodermal cells above it to elongate into columnar neural plate cells. The neural plate subsequently develops into the neural tube, which gives rise to the central nervous system. RBO_relaxed.owl GO:0001889 biolink:NamedThing liver development The process whose specific outcome is the progression of the liver over time, from its formation to the mature structure. The liver is an exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes. RBO_relaxed.owl GO:0002088 biolink:NamedThing lens development in camera-type eye The process whose specific outcome is the progression of the lens over time, from its formation to the mature structure. The lens is a transparent structure in the eye through which light is focused onto the retina. An example of this process is found in Mus musculus. RBO_relaxed.owl GO:0002119 biolink:NamedThing nematode larval development The process whose specific outcome is the progression of the nematode larva over time, from its formation to the mature structure. Nematode larval development begins with the newly hatched first-stage larva (L1) and ends with the end of the last larval stage (for example the fourth larval stage (L4) in C. elegans). Each stage of nematode larval development is characterized by proliferation of specific cell lineages and an increase in body size without alteration of the basic body plan. Nematode larval stages are separated by molts in which each stage-specific exoskeleton, or cuticle, is shed and replaced anew. RBO_relaxed.owl GO:0002932 biolink:NamedThing tendon sheath development The process whose specific outcome is the progression of a tendon sheath over time, from its formation to the mature structure. A tendon sheath is a layer of membrane around a tendon. It permits the tendon to move. RBO_relaxed.owl GO:0003157 biolink:NamedThing endocardium development The process whose specific outcome is the progression of the endocardium over time, from its formation to the mature structure. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers. RBO_relaxed.owl GO:0003158 biolink:NamedThing endothelium development The process whose specific outcome is the progression of an endothelium over time, from its formation to the mature structure. Endothelium refers to the layer of cells lining blood vessels, lymphatics, the heart, and serous cavities, and is derived from bone marrow or mesoderm. Corneal endothelium is a special case, derived from neural crest cells. RBO_relaxed.owl GO:0003161 biolink:NamedThing cardiac conduction system development The process whose specific outcome is the progression of the cardiac conduction system over time, from its formation to the mature structure. The cardiac conduction system consists of specialized cardiomyocytes that regulate the frequency of heart beat. RBO_relaxed.owl GO:0003162 biolink:NamedThing atrioventricular node development The process whose specific outcome is the progression of the atrioventricular (AV) node over time, from its formation to the mature structure. The AV node is part of the cardiac conduction system that controls the timing of ventricle contraction by receiving electrical signals from the sinoatrial (SA) node and relaying them to the His-Purkinje system. RBO_relaxed.owl GO:0003163 biolink:NamedThing sinoatrial node development The process whose specific outcome is the progression of the sinoatrial (SA) node over time, from its formation to the mature structure. The SA node is part of the cardiac conduction system that controls the timing of heart muscle contraction. It relays electrical signals to the AV node. RBO_relaxed.owl GO:0003164 biolink:NamedThing His-Purkinje system development The process whose specific outcome is the progression of the His-Purkinje system over time, from its formation to the mature structure. The His-Purkinje system receives signals from the AV node and is composed of the fibers that regulate cardiac muscle contraction in the ventricles. RBO_relaxed.owl GO:0003165 biolink:NamedThing Purkinje myocyte development The process whose specific outcome is the progression of a Purkinje myocyte over time, from its formation to the mature structure. The Purkinje myocyte (also known as cardiac Purkinje fiber) is part of the cardiac conduction system that receives signals from the bundle of His and innervates the ventricular cardiac muscle. RBO_relaxed.owl GO:0003197 biolink:NamedThing endocardial cushion development The progression of a cardiac cushion over time, from its initial formation to the mature structure. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves. RBO_relaxed.owl GO:0003204 biolink:NamedThing cardiac skeleton development The progression of the cardiac skeleton over time, from its formation to the mature structure. The cardiac skeleton is a specialized extracellular matrix that separates the atria from the ventricles and provides physical support for the heart. RBO_relaxed.owl GO:0003205 biolink:NamedThing cardiac chamber development The progression of a cardiac chamber over time, from its formation to the mature structure. A cardiac chamber is an enclosed cavity within the heart. RBO_relaxed.owl GO:0003228 biolink:NamedThing atrial cardiac muscle tissue development The process whose specific outcome is the progression of cardiac muscle of the atrium over time, from its formation to the mature structure. RBO_relaxed.owl GO:0003229 biolink:NamedThing ventricular cardiac muscle tissue development The process whose specific outcome is the progression of ventricular cardiac muscle over time, from its formation to the mature structure. RBO_relaxed.owl GO:0003230 biolink:NamedThing cardiac atrium development The process whose specific outcome is the progression of a cardiac atrium over time, from its formation to the mature structure. A cardiac atrium receives blood from a vein and pumps it to a cardiac ventricle. RBO_relaxed.owl GO:0003231 biolink:NamedThing cardiac ventricle development The process whose specific outcome is the progression of a cardiac ventricle over time, from its formation to the mature structure. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart. RBO_relaxed.owl GO:0003235 biolink:NamedThing sinus venosus development The progression of the sinus venosus over time, from its formation to the mature structure. The sinus venosus is a heart chamber attached to the atrium on the venous side of the embryonic heart. RBO_relaxed.owl GO:0003279 biolink:NamedThing cardiac septum development The progression of a cardiac septum over time, from its initial formation to the mature structure. RBO_relaxed.owl GO:0003281 biolink:NamedThing ventricular septum development The progression of the ventricular septum over time from its formation to the mature structure. RBO_relaxed.owl GO:0003283 biolink:NamedThing atrial septum development The progression of the atrial septum over time, from its initial formation to the mature structure. RBO_relaxed.owl GO:0003313 biolink:NamedThing heart rudiment development The progression of the heart rudiment over time, from its initial formation to the mature structure. The heart rudiment is a cone-like structure that is formed when myocardial progenitor cells of the heart field fuse at the midline. The heart rudiment is the first structure of the heart tube. RBO_relaxed.owl GO:0003342 biolink:NamedThing proepicardium development The progression of the proepicardium from its formation to the mature structure. The proepicardium is an outpouching of the septum transversum. RBO_relaxed.owl GO:0003343 biolink:NamedThing septum transversum development The progression of the septum transversum from its initial formation to the mature structure. The septum transversum is a portion of the trunk mesenchyme. RBO_relaxed.owl GO:0003360 biolink:NamedThing brainstem development The progression of the brainstem from its formation to the mature structure. The brainstem is the part of the brain that connects the brain with the spinal cord. RBO_relaxed.owl GO:0003407 biolink:NamedThing neural retina development The progression of the neural retina over time from its initial formation to the mature structure. The neural retina is the part of the retina that contains neurons and photoreceptor cells. RBO_relaxed.owl GO:0007275 biolink:NamedThing multicellular organism development The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). RBO_relaxed.owl GO:0007398 biolink:NamedThing ectoderm development The process whose specific outcome is the progression of the ectoderm over time, from its formation to the mature structure. In animal embryos, the ectoderm is the outer germ layer of the embryo, formed during gastrulation. RBO_relaxed.owl GO:0007420 biolink:NamedThing brain development The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.). RBO_relaxed.owl GO:0007423 biolink:NamedThing sensory organ development The process whose specific outcome is the progression of sensory organs over time, from its formation to the mature structure. RBO_relaxed.owl GO:0007492 biolink:NamedThing endoderm development The process whose specific outcome is the progression of the endoderm over time, from its formation to the mature structure. The endoderm is the innermost germ layer that develops into the gastrointestinal tract, the lungs and associated tissues. RBO_relaxed.owl GO:0007494 biolink:NamedThing midgut development The process whose specific outcome is the progression of the midgut over time, from its formation to the mature structure. The midgut is the middle part of the alimentary canal from the stomach, or entrance of the bile duct, to, or including, the large intestine. RBO_relaxed.owl GO:0007498 biolink:NamedThing mesoderm development The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue. RBO_relaxed.owl GO:0007506 biolink:NamedThing gonadal mesoderm development The process whose specific outcome is the progression of the gonadal mesoderm over time, from its formation to the mature structure. The gonadal mesoderm is the middle layer of the three primary germ layers of the embryo which will go on to form the gonads of the organism. RBO_relaxed.owl GO:0007507 biolink:NamedThing heart development The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. RBO_relaxed.owl GO:0007517 biolink:NamedThing muscle organ development The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work. RBO_relaxed.owl GO:0007519 biolink:NamedThing skeletal muscle tissue development The developmental sequence of events leading to the formation of adult skeletal muscle tissue. The main events are: the fusion of myoblasts to form myotubes that increase in size by further fusion to them of myoblasts, the formation of myofibrils within their cytoplasm and the establishment of functional neuromuscular junctions with motor neurons. At this stage they can be regarded as mature muscle fibers. RBO_relaxed.owl GO:0008406 biolink:NamedThing gonad development The process whose specific outcome is the progression of the gonad over time, from its formation to the mature structure. The gonad is an animal organ that produces gametes; in some species it also produces hormones. RBO_relaxed.owl GO:0008585 biolink:NamedThing female gonad development The process whose specific outcome is the progression of the female gonad over time, from its formation to the mature structure. RBO_relaxed.owl GO:0009790 biolink:NamedThing embryo development The process whose specific outcome is the progression of an embryo from its formation until the end of its embryonic life stage. The end of the embryonic stage is organism-specific. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant. RBO_relaxed.owl GO:0009888 biolink:NamedThing tissue development The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure. RBO_relaxed.owl GO:0014706 biolink:NamedThing striated muscle tissue development The process whose specific outcome is the progression of a striated muscle over time, from its formation to the mature structure. Striated muscle contain fibers that are divided by transverse bands into striations, and cardiac and skeletal muscle are types of striated muscle. Skeletal muscle myoblasts fuse to form myotubes and eventually multinucleated muscle fibers. The fusion of cardiac cells is very rare and can only form binucleate cells. RBO_relaxed.owl GO:0021510 biolink:NamedThing spinal cord development The process whose specific outcome is the progression of the spinal cord over time, from its formation to the mature structure. The spinal cord primarily conducts sensory and motor nerve impulses between the brain and the peripheral nervous tissues. RBO_relaxed.owl GO:0021517 biolink:NamedThing ventral spinal cord development The process whose specific outcome is the progression of the ventral region of the spinal cord over time, from its formation to the mature structure. The neurons of the ventral region of the mature spinal cord participate in motor output. RBO_relaxed.owl GO:0021545 biolink:NamedThing cranial nerve development The process whose specific outcome is the progression of the cranial nerves over time, from its formation to the mature structure. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions. RBO_relaxed.owl GO:0021546 biolink:NamedThing rhombomere development The process whose specific outcome is the progression of the rhombomere over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. RBO_relaxed.owl GO:0021548 biolink:NamedThing pons development The process whose specific outcome is the progression of the pons over time, from its formation to the mature structure. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum. RBO_relaxed.owl GO:0021550 biolink:NamedThing medulla oblongata development The process whose specific outcome is the progression of the medulla oblongata over time, from its formation to the mature structure. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate. RBO_relaxed.owl GO:0021559 biolink:NamedThing trigeminal nerve development The process whose specific outcome is the progression of the trigeminal nerve over time, from its formation to the mature structure. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae. RBO_relaxed.owl GO:0021675 biolink:NamedThing nerve development The process whose specific outcome is the progression of a nerve over time, from its formation to the mature structure. RBO_relaxed.owl GO:0021703 biolink:NamedThing locus ceruleus development The process whose specific outcome is the progression of the locus ceruleus over time, from its formation to the mature structure. The locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic. RBO_relaxed.owl GO:0021718 biolink:NamedThing superior olivary nucleus development The process whose specific outcome is the progression of the superior olivary nucleus over time, from its formation to the mature structure. In mice, the superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound. RBO_relaxed.owl GO:0021751 biolink:NamedThing salivary nucleus development The process whose specific outcome is the progression of a salivary nucleus over time, from its formation to the mature structure. RBO_relaxed.owl GO:0021753 biolink:NamedThing superior salivary nucleus development The process whose specific outcome is the progression of the superior salivary nucleus over time, from its formation to the mature structure. RBO_relaxed.owl GO:0021915 biolink:NamedThing neural tube development The process whose specific outcome is the progression of the neural tube over time, from its formation to the mature structure. The mature structure of the neural tube exists when the tube has been segmented into the forebrain, midbrain, hindbrain and spinal cord regions. In addition neural crest has budded away from the epithelium. RBO_relaxed.owl GO:0022037 biolink:NamedThing metencephalon development The process whose specific outcome is the progression of the metencephalon over time, from its formation to the mature structure. RBO_relaxed.owl GO:0030323 biolink:NamedThing respiratory tube development The process whose specific outcome is the progression of the respiratory tube over time, from its formation to the mature structure. The respiratory tube is assumed to mean any tube in the respiratory tract. RBO_relaxed.owl GO:0030324 biolink:NamedThing lung development The process whose specific outcome is the progression of the lung over time, from its formation to the mature structure. In all air-breathing vertebrates the lungs are developed from the ventral wall of the oesophagus as a pouch which divides into two sacs. In amphibians and many reptiles the lungs retain very nearly this primitive sac-like character, but in the higher forms the connection with the esophagus becomes elongated into the windpipe and the inner walls of the sacs become more and more divided, until, in the mammals, the air spaces become minutely divided into tubes ending in small air cells, in the walls of which the blood circulates in a fine network of capillaries. In mammals the lungs are more or less divided into lobes, and each lung occupies a separate cavity in the thorax. RBO_relaxed.owl GO:0030901 biolink:NamedThing midbrain development The process whose specific outcome is the progression of the midbrain over time, from its formation to the mature structure. The midbrain is the middle division of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes a ventral part containing the cerebral peduncles and a dorsal tectum containing the corpora quadrigemina and that surrounds the aqueduct of Sylvius connecting the third and fourth ventricles). RBO_relaxed.owl GO:0030902 biolink:NamedThing hindbrain development The process whose specific outcome is the progression of the hindbrain over time, from its formation to the mature structure. The hindbrain is the posterior of the three primary divisions of the developing chordate brain, or the corresponding part of the adult brain (in vertebrates, includes the cerebellum, pons, and medulla oblongata and controls the autonomic functions and equilibrium). RBO_relaxed.owl GO:0030903 biolink:NamedThing notochord development The process whose specific outcome is the progression of the notochord over time, from its formation to the mature structure. The notochord is a mesoderm-derived structure located ventral of the developing nerve cord. In vertebrates, the notochord serves as a core around which other mesodermal cells form the vertebrae. In the most primitive chordates, which lack vertebrae, the notochord persists as a substitute for a vertebral column. RBO_relaxed.owl GO:0030917 biolink:NamedThing midbrain-hindbrain boundary development The process whose specific outcome is the progression of the midbrain-hindbrain boundary over time, from its formation to the mature structure. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. RBO_relaxed.owl GO:0031016 biolink:NamedThing pancreas development The process whose specific outcome is the progression of the pancreas over time, from its formation to the mature structure. The pancreas is an endoderm derived structure that produces precursors of digestive enzymes and blood glucose regulating hormones. RBO_relaxed.owl GO:0031017 biolink:NamedThing exocrine pancreas development The process whose specific outcome is the progression of the exocrine pancreas over time, from its formation to the mature structure. The exocrine pancreas produces and store zymogens of digestive enzymes, such as chymotrypsinogen and trypsinogen in the acinar cells. RBO_relaxed.owl GO:0031018 biolink:NamedThing endocrine pancreas development The process whose specific outcome is the progression of the endocrine pancreas over time, from its formation to the mature structure. The endocrine pancreas is made up of islet cells that produce insulin, glucagon and somatostatin. RBO_relaxed.owl GO:0035050 biolink:NamedThing embryonic heart tube development The process whose specific outcome is the progression of the embryonic heart tube over time, from its formation to the mature structure. The heart tube forms as the heart rudiment from the heart field. RBO_relaxed.owl GO:0035295 biolink:NamedThing tube development The process whose specific outcome is the progression of a tube over time, from its initial formation to a mature structure. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues including lung and trachea, kidney, the mammary gland, the vascular system and the gastrointestinal and urinary-genital tracts. RBO_relaxed.owl GO:0035622 biolink:NamedThing intrahepatic bile duct development The progression of the intrahepatic bile ducts over time, from their formation to the mature structure. Intrahepatic bile ducts (bile ducts within the liver) collect bile from bile canaliculi in the liver, and connect to the extrahepatic bile ducts (bile ducts outside the liver). RBO_relaxed.owl GO:0035628 biolink:NamedThing cystic duct development The progression of the cystic duct over time, from its formation to the mature structure. The cystic duct runs from the gallbladder to the common bile duct. RBO_relaxed.owl GO:0035844 biolink:NamedThing cloaca development The process whose specific outcome is the progression of the cloaca over time, from it's formation to the mature structure. The cloaca is the common chamber into which intestinal, genital and urinary canals open in vertebrates. RBO_relaxed.owl GO:0035855 biolink:NamedThing megakaryocyte development The process whose specific outcome is the progression of a megakaryocyte cell over time, from its formation to the mature structure. Megakaryocyte development does not include the steps involved in committing a cell to a megakaryocyte fate. A megakaryocyte is a giant cell 50 to 100 micron in diameter, with a greatly lobulated nucleus, found in the bone marrow. RBO_relaxed.owl GO:0035904 biolink:NamedThing aorta development The progression of the aorta over time, from its initial formation to the mature structure. An aorta is an artery that carries blood from the heart to other parts of the body. RBO_relaxed.owl GO:0035905 biolink:NamedThing ascending aorta development The progression of the ascending aorta over time, from its initial formation to the mature structure. The ascending aorta is the portion of the aorta in a two-pass circulatory system that lies between the heart and the arch of aorta. In a two-pass circulatory system blood passes twice through the heart to supply the body once. RBO_relaxed.owl GO:0035906 biolink:NamedThing descending aorta development The progression of the descending aorta over time, from its initial formation to the mature structure. The descending aorta is the portion of the aorta in a two-pass circulatory system from the arch of aorta to the point where it divides into the common iliac arteries. In a two-pass circulatory system blood passes twice through the heart to supply the body once. RBO_relaxed.owl GO:0035907 biolink:NamedThing dorsal aorta development The progression of the dorsal aorta over time, from its initial formation to the mature structure. The dorsal aorta is a blood vessel in a single-pass circulatory system that carries oxygenated blood from the gills to the rest of the body. In a single-pass circulatory system blood passes once through the heart to supply the body once. RBO_relaxed.owl GO:0035989 biolink:NamedThing tendon development The process whose specific outcome is the progression of a tendon over time, from its formation to the mature structure. A tendon is a fibrous, strong, connective tissue that connects muscle to bone or integument and is capable of withstanding tension. Tendons and muscles work together to exert a pulling force. RBO_relaxed.owl GO:0043010 biolink:NamedThing camera-type eye development The process whose specific outcome is the progression of the camera-type eye over time, from its formation to the mature structure. The camera-type eye is an organ of sight that receives light through an aperture and focuses it through a lens, projecting it on a photoreceptor field. RBO_relaxed.owl GO:0043588 biolink:NamedThing skin development The process whose specific outcome is the progression of the skin over time, from its formation to the mature structure. The skin is the external membranous integument of an animal. In vertebrates the skin generally consists of two layers, an outer nonsensitive and nonvascular epidermis (cuticle or skarfskin) composed of cells which are constantly growing and multiplying in the deeper, and being thrown off in the superficial layers, as well as an inner vascular dermis (cutis, corium or true skin) composed mostly of connective tissue. RBO_relaxed.owl GO:0048318 biolink:NamedThing axial mesoderm development The process whose specific outcome is the progression of the axial mesoderm over time, from its formation to the mature structure. The axial mesoderm includes the prechordal mesoderm and the chordamesoderm. It gives rise to the prechordal plate and to the notochord. RBO_relaxed.owl GO:0048339 biolink:NamedThing paraxial mesoderm development The process whose specific outcome is the progression of the paraxial mesoderm over time, from its formation to the mature structure. The paraxial mesoderm is the mesoderm located bilaterally adjacent to the notochord and neural tube. RBO_relaxed.owl GO:0048368 biolink:NamedThing lateral mesoderm development The process whose specific outcome is the progression of the lateral mesoderm over time, from its formation to the mature structure. RBO_relaxed.owl GO:0048389 biolink:NamedThing intermediate mesoderm development The process whose specific outcome is the progression of the intermediate mesoderm over time, from its formation to the mature structure. The intermediate mesoderm is located between the lateral mesoderm and the paraxial mesoderm. It develops into the kidney and gonads. RBO_relaxed.owl GO:0048513 biolink:NamedThing animal organ development Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions. RBO_relaxed.owl GO:0048536 biolink:NamedThing spleen development The process whose specific outcome is the progression of the spleen over time, from its formation to the mature structure. The spleen is a large vascular lymphatic organ composed of white and red pulp, involved both in hemopoietic and immune system functions. RBO_relaxed.owl GO:0048539 biolink:NamedThing bone marrow development The process whose specific outcome is the progression of the bone marrow over time, from its formation to the mature structure. RBO_relaxed.owl GO:0048565 biolink:NamedThing digestive tract development The process whose specific outcome is the progression of the digestive tract over time, from its formation to the mature structure. The digestive tract is the anatomical structure through which food passes and is processed. RBO_relaxed.owl GO:0048568 biolink:NamedThing embryonic organ development Development, taking place during the embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions. RBO_relaxed.owl GO:0048608 biolink:NamedThing reproductive structure development The reproductive developmental process whose specific outcome is the progression of somatic structures that will be used in the process of creating new individuals from one or more parents, from their formation to the mature structures. RBO_relaxed.owl GO:0048732 biolink:NamedThing gland development The process whose specific outcome is the progression of a gland over time, from its formation to the mature structure. A gland is an organ specialised for secretion. RBO_relaxed.owl GO:0048736 biolink:NamedThing appendage development The process whose specific outcome is the progression of an appendage over time, from its formation to the mature structure. An appendage is an organ or part that is attached to the trunk of an organism, such as a limb or a branch. RBO_relaxed.owl GO:0048738 biolink:NamedThing cardiac muscle tissue development The process whose specific outcome is the progression of cardiac muscle over time, from its formation to the mature structure. RBO_relaxed.owl GO:0048741 biolink:NamedThing skeletal muscle fiber development The process whose specific outcome is the progression of the skeletal muscle fiber over time, from its formation to the mature structure. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast. RBO_relaxed.owl GO:0048745 biolink:NamedThing smooth muscle tissue development The process whose specific outcome is the progression of smooth muscle over time, from its formation to the mature structure. RBO_relaxed.owl GO:0048749 biolink:NamedThing compound eye development The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye. RBO_relaxed.owl GO:0048857 biolink:NamedThing neural nucleus development The biological process whose specific outcome is the progression of a neural nucleus from its initial condition to its mature state. A neural nucleus is an anatomical structure consisting of a discrete aggregate of neuronal soma. RBO_relaxed.owl GO:0051216 biolink:NamedThing cartilage development The process whose specific outcome is the progression of a cartilage element over time, from its formation to the mature structure. Cartilage elements are skeletal elements that consist of connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate. RBO_relaxed.owl GO:0060021 biolink:NamedThing roof of mouth development The biological process whose specific outcome is the progression of the roof of the mouth from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure. The roof of the mouth is the partition that separates the nasal and oral cavities. RBO_relaxed.owl GO:0060039 biolink:NamedThing pericardium development The process whose specific outcome is the progression of the pericardium over time, from its formation to the mature structure. The pericardium is a double-walled sac that contains the heart and the roots of the aorta, vena cava and the pulmonary artery. RBO_relaxed.owl GO:0060041 biolink:NamedThing retina development in camera-type eye The process whose specific outcome is the progression of the retina over time, from its formation to the mature structure. The retina is the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates. RBO_relaxed.owl GO:0060173 biolink:NamedThing limb development The process whose specific outcome is the progression of a limb over time, from its formation to the mature structure. A limb is an appendage of an animal used for locomotion or grasping. Examples include legs, arms or some types of fin. RBO_relaxed.owl GO:0060322 biolink:NamedThing head development The biological process whose specific outcome is the progression of a head from an initial condition to its mature state. The head is the anterior-most division of the body. RBO_relaxed.owl GO:0060324 biolink:NamedThing face development The biological process whose specific outcome is the progression of a face from an initial condition to its mature state. The face is the ventral division of the head. RBO_relaxed.owl GO:0060426 biolink:NamedThing lung vasculature development The biological process whose specific outcome is the progression of a lung vasculature from an initial condition to its mature state. This process begins with the formation of the lung vasculature and ends with the mature structure. The lung vasculature is composed of the tubule structures that carry blood or lymph in the lungs. RBO_relaxed.owl GO:0060427 biolink:NamedThing lung connective tissue development The biological process whose specific outcome is the progression of lung connective tissue from an initial condition to its mature state. This process begins with the formation of lung connective tissue and ends with the mature structure. The lung connective tissue is a material made up of fibers forming a framework and support structure for the lungs. RBO_relaxed.owl GO:0060428 biolink:NamedThing lung epithelium development The biological process whose specific outcome is the progression of the lung epithelium from an initial condition to its mature state. This process begins with the formation of lung epithelium and ends with the mature structure. The lung epithelium is the specialized epithelium that lines the inside of the lung. RBO_relaxed.owl GO:0060429 biolink:NamedThing epithelium development The process whose specific outcome is the progression of an epithelium over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure. RBO_relaxed.owl GO:0060438 biolink:NamedThing trachea development The process whose specific outcome is the progression of a trachea over time, from its formation to the mature structure. The trachea is the portion of the airway that attaches to the bronchi as it branches. RBO_relaxed.owl GO:0060458 biolink:NamedThing right lung development The biological process whose specific outcome is the progression of a right lung from an initial condition to its mature state. This process begins with the formation of the right lung and ends with the mature structure. The right lung is the lung which is on the right side of the anterior posterior axis looking from a dorsal to ventral aspect. RBO_relaxed.owl GO:0060459 biolink:NamedThing left lung development The biological process whose specific outcome is the progression of a left lung from an initial condition to its mature state. This process begins with the formation of the left lung and ends with the mature structure. The left lung is the lung which is on the left side of the anterior posterior axis looking from a dorsal to ventral aspect. RBO_relaxed.owl GO:0060462 biolink:NamedThing lung lobe development The biological process whose specific outcome is the progression of a lung lobe from an initial condition to its mature state. This process begins with the formation of a lung lobe by branching morphogenesis and ends with the mature structure. A lung lobe is one of the rounded projections that compose the lung. RBO_relaxed.owl GO:0060465 biolink:NamedThing pharynx development The biological process whose specific outcome is the progression of a pharynx from an initial condition to its mature state. The pharynx is the part of the digestive system immediately posterior to the mouth. RBO_relaxed.owl GO:0060485 biolink:NamedThing mesenchyme development The process whose specific outcome is the progression of a mesenchymal tissue over time, from its formation to the mature structure. A mesenchymal tissue is made up of loosely packed stellate cells. RBO_relaxed.owl GO:0060537 biolink:NamedThing muscle tissue development The progression of muscle tissue over time, from its initial formation to its mature state. Muscle tissue is a contractile tissue made up of actin and myosin fibers. RBO_relaxed.owl GO:0060538 biolink:NamedThing skeletal muscle organ development The progression of a skeletal muscle organ over time from its initial formation to its mature state. A skeletal muscle organ includes the skeletal muscle tissue and its associated connective tissue. RBO_relaxed.owl GO:0060539 biolink:NamedThing diaphragm development The progression of the diaphragm over time from its initial formation to the mature structure. The diaphragm is a skeletal muscle that is responsible for contraction and expansion of the lungs. RBO_relaxed.owl GO:0060576 biolink:NamedThing intestinal epithelial cell development The process whose specific outcome is the progression of a columnar/cuboidal epithelial cell of the intestine over time, from its formation to the mature structure. RBO_relaxed.owl GO:0060612 biolink:NamedThing adipose tissue development The process whose specific outcome is the progression of adipose tissue over time, from its formation to the mature structure. Adipose tissue is specialized tissue that is used to store fat. RBO_relaxed.owl GO:0060840 biolink:NamedThing artery development The progression of the artery over time, from its initial formation to the mature structure. An artery is a blood vessel that carries blood away from the heart to a capillary bed. RBO_relaxed.owl GO:0060841 biolink:NamedThing venous blood vessel development The progression of the venous blood vessel over time from its initial formation to the mature structure. Venous blood vessels carry blood back to the heart after the capillary bed. RBO_relaxed.owl GO:0060926 biolink:NamedThing cardiac pacemaker cell development The process whose specific outcome is the progression of a pacemaker cell over time, from its formation to the mature state. Pacemaker cells are specialized cardiomyocytes that are responsible for regulating the timing of heart contractions. RBO_relaxed.owl GO:0060958 biolink:NamedThing endocardial cell development The progression of an endocardial cell over time, from its formation to the mature cell. An endocardial cell is a specialized endothelial cell that makes up the endocardium portion of the heart. RBO_relaxed.owl GO:0060976 biolink:NamedThing coronary vasculature development The process whose specific outcome is the progression of the blood vessels of the heart over time, from its formation to the mature structure. RBO_relaxed.owl GO:0061009 biolink:NamedThing common bile duct development The progression of the common bile duct over time, from its formation to the mature structure. The common bile duct is formed from the joining of the common hepatic duct running from the liver, and the cystic duct running from the gallbladder. The common bile duct transports bile from the liver and gallbladder to the intestine. RBO_relaxed.owl GO:0061010 biolink:NamedThing gallbladder development The progression of the gallbladder over time, from its initial formation to the mature structure. The gallbladder is a cavitated organ that stores bile. RBO_relaxed.owl GO:0061011 biolink:NamedThing hepatic duct development The progression of the hepatic duct over time, from its formation to the mature structure. The hepatic duct is the duct that leads from the liver to the common bile duct. RBO_relaxed.owl GO:0061032 biolink:NamedThing visceral serous pericardium development The progression of the visceral serous pericardium from its formation to the mature structure. The visceral serous pericardium is the inner layer of the pericardium. RBO_relaxed.owl GO:0061053 biolink:NamedThing somite development The progression of a somite from its initial formation to the mature structure. Somites are mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo. RBO_relaxed.owl GO:0061054 biolink:NamedThing dermatome development The progression of the dermatome over time, from its initial formation to the mature structure. The dermatome is the portion of a somite that will form skin. RBO_relaxed.owl GO:0061055 biolink:NamedThing myotome development The progression of the myotome over time, from its formation to the mature structure. The myotome is the portion of the somite that will give rise to muscle. RBO_relaxed.owl GO:0061056 biolink:NamedThing sclerotome development The progression of the sclerotome over time, from its initial formation to the mature structure. The sclerotome is the portion of the somite that will give rise to a vertebra. RBO_relaxed.owl GO:0061061 biolink:NamedThing muscle structure development The progression of a muscle structure over time, from its formation to its mature state. Muscle structures are contractile cells, tissues or organs that are found in multicellular organisms. RBO_relaxed.owl GO:0061080 biolink:NamedThing right horn of sinus venosus development The progression of the right horn of the sinus venosus from its formation to the mature structure. RBO_relaxed.owl GO:0061147 biolink:NamedThing endocardial endothelium development The progression of the endocardial endothelium over time, from its initial formation to the mature structure. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers. RBO_relaxed.owl GO:0061298 biolink:NamedThing retina vasculature development in camera-type eye The process whose specific outcome is the progression of the vasculature of the retina over time, from its formation to the mature structure. RBO_relaxed.owl GO:0061303 biolink:NamedThing cornea development in camera-type eye The progression of the cornea over time, from its formation to the mature structure. The cornea is the transparent structure that covers the anterior of the eye. RBO_relaxed.owl GO:0061448 biolink:NamedThing connective tissue development The progression of a connective tissue over time, from its formation to the mature structure. RBO_relaxed.owl GO:0061525 biolink:NamedThing hindgut development The process whose specific outcome is the progression of the hindgut over time, from its formation to the mature structure. The hindgut is part of the alimentary canal that lies posterior to the midgut. RBO_relaxed.owl GO:0061548 biolink:NamedThing ganglion development The process whose specific outcome is the progression of a ganglion over time, from its formation to the mature structure. RBO_relaxed.owl GO:0061549 biolink:NamedThing sympathetic ganglion development The process whose specific outcome is the progression of a sympathetic ganglion over time, from its formation to the mature structure. RBO_relaxed.owl GO:0061550 biolink:NamedThing cranial ganglion development The process whose specific outcome is the progression of a cranial ganglion over time, from its formation to the mature structure. RBO_relaxed.owl GO:0061551 biolink:NamedThing trigeminal ganglion development The process whose specific outcome is the progression of a trigeminal ganglion over time, from its formation to the mature structure. RBO_relaxed.owl GO:0062094 biolink:NamedThing stomach development The process whose specific outcome is the progression of the stomach over time, from its formation to the mature structure. The stomach is an expanded region of the vertebrate alimentary tract that serves as a food storage compartment and digestive organ. RBO_relaxed.owl GO:0071696 biolink:NamedThing ectodermal placode development The progression of an ectodermal placode over time from its initial formation until its mature state. An ectodermal placode is a thickening of the ectoderm that is the primordium of many structures derived from the ectoderm. RBO_relaxed.owl GO:0072360 biolink:NamedThing vascular cord development The progression of the vascular cord over time from its initial formation until its mature state. The vascular cord is the primordial vasculature that will develop into blood vessels by the process of tubulogenesis. RBO_relaxed.owl GO:0097084 biolink:NamedThing vascular associated smooth muscle cell development The process aimed at the progression of a vascular smooth muscle cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. A vascular smooth muscle cell is a non-striated, elongated, spindle-shaped cell found lining the blood vessels. RBO_relaxed.owl GO:0098773 biolink:NamedThing skin epidermis development The process whose specific outcome is the progression of the skin epidermis over time, from its formation to the mature structure. RBO_relaxed.owl GO:0160038 biolink:NamedThing somatic sensory system development The process whose specific outcome is the progression of a somatic sensory system over time from its formation to the mature structure. Somatic sensory system is the sensory system for the sense of touch and pain. RBO_relaxed.owl GO:0160093 biolink:NamedThing chordate pharynx development The process whose specific outcome is the progression of cordate pharynx over time, from its formation to the mature structure. RBO_relaxed.owl GO:1903701 biolink:NamedThing substantia propria of cornea development The process whose specific outcome is the progression of a substantia propria of cornea over time, from its formation to the mature structure. RBO_relaxed.owl GO:1903702 biolink:NamedThing esophagus development The process whose specific outcome is the progression of an esophagus over time, from its formation to the mature structure. RBO_relaxed.owl GO:1903867 biolink:NamedThing extraembryonic membrane development The process whose specific outcome is the progression of an extraembryonic membrane over time, from its formation to the mature structure. RBO_relaxed.owl GO:1904484 biolink:NamedThing cloacal gland development The process whose specific outcome is the progression of a cloacal gland over time, from its formation to the mature structure. RBO_relaxed.owl GO:1904817 biolink:NamedThing serous membrane development The process whose specific outcome is the progression of a serous membrane over time, from its formation to the mature structure. RBO_relaxed.owl GO:1904818 biolink:NamedThing visceral peritoneum development The process whose specific outcome is the progression of a visceral peritoneum over time, from its formation to the mature structure. RBO_relaxed.owl GO:1904819 biolink:NamedThing parietal peritoneum development The process whose specific outcome is the progression of a parietal peritoneum over time, from its formation to the mature structure. RBO_relaxed.owl GO:1904820 biolink:NamedThing peritoneum development The process whose specific outcome is the progression of a peritoneum over time, from its formation to the mature structure. RBO_relaxed.owl GO:1904888 biolink:NamedThing cranial skeletal system development The process whose specific outcome is the progression of a cranial skeletal system over time, from its formation to the mature structure. The cranial skeletal system is the skeletal subdivision of the head, and includes the skull (cranium plus mandible), pharyngeal and/or hyoid apparatus. RBO_relaxed.owl GO:0001503 biolink:NamedThing ossification The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance. RBO_relaxed.owl GO:0003008 biolink:NamedThing system process A multicellular organismal process carried out by any of the organs or tissues in an organ system. An organ system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a biological objective. RBO_relaxed.owl GO:0007389 biolink:NamedThing pattern specification process Any developmental process that results in the creation of defined areas or spaces within an organism to which cells respond and eventually are instructed to differentiate. RBO_relaxed.owl GO:0007585 biolink:NamedThing respiratory gaseous exchange by respiratory system The process of gaseous exchange between an organism and its environment. In plants, microorganisms, and many small animals, air or water makes direct contact with the organism's cells or tissue fluids, and the processes of diffusion supply the organism with dioxygen (O2) and remove carbon dioxide (CO2). In larger animals the efficiency of gaseous exchange is improved by specialized respiratory organs, such as lungs and gills, which are ventilated by breathing mechanisms. RBO_relaxed.owl GO:0007586 biolink:NamedThing digestion The whole of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism. RBO_relaxed.owl GO:0007610 biolink:NamedThing behavior The internally coordinated responses (actions or inactions) of animals (individuals or groups) to internal or external stimuli, via a mechanism that involves nervous system activity. RBO_relaxed.owl GO:0009791 biolink:NamedThing post-embryonic development The process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. See embryonic development. RBO_relaxed.owl GO:0032504 biolink:NamedThing multicellular organism reproduction The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents. RBO_relaxed.owl GO:0032941 biolink:NamedThing secretion by tissue The controlled release of a substance by a tissue. RBO_relaxed.owl GO:0035264 biolink:NamedThing multicellular organism growth The increase in size or mass of an entire multicellular organism, as opposed to cell growth. RBO_relaxed.owl GO:0035265 biolink:NamedThing organ growth The increase in size or mass of an organ. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that function together as to perform a specific function. RBO_relaxed.owl GO:0048871 biolink:NamedThing multicellular organismal-level homeostasis Any process involved in the maintenance of an internal steady state at the level of the multicellular organism. RBO_relaxed.owl GO:0050879 biolink:NamedThing multicellular organismal movement Any physiological process involved in changing the position of a multicellular organism or an anatomical part of a multicellular organism. RBO_relaxed.owl GO:0001508 biolink:NamedThing action potential A process in which membrane potential cycles through a depolarizing spike, triggered in response to depolarization above some threshold, followed by repolarization. This cycle is driven by the flow of ions through various voltage gated channels with different thresholds and ion specificities. RBO_relaxed.owl GO:0016057 biolink:NamedThing regulation of membrane potential in photoreceptor cell Hyperpolarization (vertebrates) or depolarization (invertebrates) of the photoreceptor cell membrane via closing/opening of cation specific channels as a result of signals generated by rhodopsin activation by a photon. RBO_relaxed.owl GO:0001525 biolink:NamedThing angiogenesis Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels. RBO_relaxed.owl GO:0048646 biolink:NamedThing anatomical structure formation involved in morphogenesis The developmental process pertaining to the initial formation of an anatomical structure from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome. RBO_relaxed.owl GO:0001704 biolink:NamedThing formation of primary germ layer The formation of the ectoderm, mesoderm and endoderm during gastrulation. RBO_relaxed.owl GO:0001705 biolink:NamedThing ectoderm formation The formation of ectoderm during gastrulation. RBO_relaxed.owl GO:0001706 biolink:NamedThing endoderm formation The formation of the endoderm during gastrulation. RBO_relaxed.owl GO:0001707 biolink:NamedThing mesoderm formation The process that gives rise to the mesoderm. This process pertains to the initial formation of the structure from unspecified parts. RBO_relaxed.owl GO:0001743 biolink:NamedThing lens placode formation The initial developmental process that will lead to the formation of an eye. RBO_relaxed.owl GO:0001756 biolink:NamedThing somitogenesis The formation of mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo. RBO_relaxed.owl GO:0001825 biolink:NamedThing blastocyst formation The initial formation of a blastocyst from a solid ball of cells known as a morula. RBO_relaxed.owl GO:0001841 biolink:NamedThing neural tube formation The formation of a tube from the flat layer of ectodermal cells known as the neural plate. This will give rise to the central nervous system. RBO_relaxed.owl GO:0001842 biolink:NamedThing neural fold formation The process in which the neural fold is formed. The edges of the neural plate thicken and move up to form a U-shaped structure called the neural groove. RBO_relaxed.owl GO:0003144 biolink:NamedThing embryonic heart tube formation The process that gives rise to the embryonic heart tube. This process pertains to the initial formation of a structure from unspecified parts. The embryonic heart tube is an epithelial tube that will give rise to the mature heart. RBO_relaxed.owl GO:0003207 biolink:NamedThing cardiac chamber formation The developmental process pertaining to the initial formation of a cardiac chamber from unspecified parts. A cardiac chamber is an enclosed cavity within the heart. RBO_relaxed.owl GO:0003210 biolink:NamedThing cardiac atrium formation The developmental process pertaining to the initial formation of a cardiac atrium from unspecified parts. A cardiac atrium receives blood from a vein and pumps it to a cardiac ventricle. RBO_relaxed.owl GO:0003211 biolink:NamedThing cardiac ventricle formation The developmental process pertaining to the initial formation of a cardiac ventricle from unspecified parts. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart. RBO_relaxed.owl GO:0003216 biolink:NamedThing cardiac left atrium formation The developmental process pertaining to the initial formation of a left cardiac atrium from unspecified parts. RBO_relaxed.owl GO:0003217 biolink:NamedThing cardiac right atrium formation The developmental process pertaining to the initial formation of a cardiac right atrium from unspecified parts. RBO_relaxed.owl GO:0003218 biolink:NamedThing cardiac left ventricle formation The developmental process pertaining to the initial formation of a left cardiac ventricle from unspecified parts. RBO_relaxed.owl GO:0003219 biolink:NamedThing cardiac right ventricle formation The developmental process pertaining to the initial formation of a right cardiac ventricle from unspecified parts. RBO_relaxed.owl GO:0003237 biolink:NamedThing sinus venosus formation The developmental process pertaining to the initial formation of the sinus venosus from unspecified parts. The sinus venosus is a heart chamber attached to the atrium on the venous side of the embryonic heart. RBO_relaxed.owl GO:0003272 biolink:NamedThing endocardial cushion formation The developmental process pertaining to the initial formation of an endocardial cushion. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves. RBO_relaxed.owl GO:0003315 biolink:NamedThing heart rudiment formation The developmental process pertaining to the initial formation of the heart rudiment. RBO_relaxed.owl GO:0003403 biolink:NamedThing optic vesicle formation The developmental process pertaining to the initial formation of the optic vesicle from the lateral wall of the forebrain. This process begins with the specific processes that contribute to the appearance of the vesicle and ends when the vesicle has evaginated. The optic vesicle is the evagination of neurectoderm that precedes formation of the optic cup. RBO_relaxed.owl GO:0007293 biolink:NamedThing germarium-derived egg chamber formation Construction of a stage-1 egg chamber in the anterior part of the germarium, from the progeny of germ-line and somatic stem cells. An example of this is found in Drosophila melanogaster. RBO_relaxed.owl GO:0010842 biolink:NamedThing retina layer formation The process in which the vertebrate retina is organized into three laminae: the outer nuclear layer (ONL), which contains photoreceptor nuclei; the inner nuclear layer (INL), which contains amacrine, bipolar and horizontal cells; and the retinal ganglion cell (RGC) layer. Between the inner and outer nuclear layers, the outer plexiform layer (OPL) contains connections between the photoreceptors and bipolar and horizontal cells. The inner plexiform layer (IPL) is positioned between the INL and the ganglion cell layer and contains the dendrites of RGCs and processes of bipolar and amacrine cells. Spanning all layers of the retina are the radially oriented Mueller glia. RBO_relaxed.owl GO:0010927 biolink:NamedThing cellular component assembly involved in morphogenesis The cellular component assembly that is part of the initial shaping of the component during its developmental progression. RBO_relaxed.owl GO:0014023 biolink:NamedThing neural rod formation The formation of a solid rod of neurectoderm derived from the neural keel. The neural rod is roughly circular in cross section. Neural rod formation occurs during primary neurulation in teleosts. RBO_relaxed.owl GO:0014025 biolink:NamedThing neural keel formation The formation of a thickened region of the neurectoderm that is roughly triangular in cross section. The neural keel develops from the neural plate and develops into the neural rod. Neural keel formation occurs during primary neurulation in teleosts. RBO_relaxed.owl GO:0014028 biolink:NamedThing notochord formation The formation of the notochord from the chordamesoderm. The notochord is composed of large cells packed within a firm connective tissue sheath and is found in all chordates at the ventral surface of the neural tube. In vertebrates, the notochord contributes to the vertebral column. RBO_relaxed.owl GO:0014029 biolink:NamedThing neural crest formation The formation of the specialized region of ectoderm between the neural ectoderm (neural plate) and non-neural ectoderm. The neural crest gives rise to the neural crest cells that migrate away from this region as neural tube formation procedes. RBO_relaxed.owl GO:0021501 biolink:NamedThing prechordal plate formation The formation of the prechordal plate. The prechordal plate is a thickening of the endoderm at the cranial end of the primitive streak formed by the involution of Spemann's organizer cells. The prechordal plate and the notochord induce the formation of the neural plate from the overlying ectodermal cells. RBO_relaxed.owl GO:0021547 biolink:NamedThing midbrain-hindbrain boundary initiation The regionalization process that gives rise to the midbrain-hindbrain boundary. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate. RBO_relaxed.owl GO:0021556 biolink:NamedThing central nervous system formation The process that gives rise to the central nervous system. This process pertains to the initial formation of a structure from unspecified parts. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain, spinal cord and spinal nerves. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord. RBO_relaxed.owl GO:0021576 biolink:NamedThing hindbrain formation The process that gives rise to the hindbrain. This process pertains to the initial formation of a structure from unspecified parts. The hindbrain is the region consisting of the medulla, pons and cerebellum. Areas of the hindbrain control motor and autonomic functions. RBO_relaxed.owl GO:0021580 biolink:NamedThing medulla oblongata formation The process that gives rise to the medulla oblongata. This process pertains to the initial formation of a structure from unspecified parts. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate. RBO_relaxed.owl GO:0021584 biolink:NamedThing pons formation The process that gives rise to the pons. This process pertains to the initial formation of a structure from unspecified parts. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum. RBO_relaxed.owl GO:0021594 biolink:NamedThing rhombomere formation The process that gives rise to the rhombomere. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. RBO_relaxed.owl GO:0021603 biolink:NamedThing cranial nerve formation The process that gives rise to the cranial nerves. This process pertains to the initial formation of a structure from unspecified parts. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions. RBO_relaxed.owl GO:0021638 biolink:NamedThing trigeminal nerve formation The process that gives rise to the trigeminal nerve. This process pertains to the initial formation of a structure from unspecified parts. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae. RBO_relaxed.owl GO:0021654 biolink:NamedThing rhombomere boundary formation The process that gives rise to a rhombomere boundary. This process pertains to the initial formation of a boundary delimiting a rhombomere. Rhombomeres are transverse segments of the developing rhombencephalon that are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order. RBO_relaxed.owl GO:0021705 biolink:NamedThing locus ceruleus formation The process that gives rise to the locus ceruleus. This process pertains to the initial formation of a structure from unspecified parts. In mice, the locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic. RBO_relaxed.owl GO:0021720 biolink:NamedThing superior olivary nucleus formation The process that gives rise to the superior olivary nucleus. This process pertains to the initial formation of a structure from unspecified parts. In mice, the superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound. RBO_relaxed.owl GO:0021906 biolink:NamedThing hindbrain-spinal cord boundary formation The process whose specific outcome is the formation of the hindbrain-spinal cord boundary. RBO_relaxed.owl GO:0021990 biolink:NamedThing neural plate formation The formation of the flat, thickened layer of ectodermal cells known as the neural plate. The underlying dorsal mesoderm signals the ectodermal cells above it to elongate into columnar neural plate cells. The neural plate subsequently develops into the neural tube, which gives rise to the central nervous system. RBO_relaxed.owl GO:0035148 biolink:NamedThing tube formation Creation of the central hole of a tube in an anatomical structure through which gases and/or liquids flow. RBO_relaxed.owl GO:0035992 biolink:NamedThing tendon formation The process that gives rise to a tendon. This process pertains to the initial formation of a tendon from unspecified parts. RBO_relaxed.owl GO:0048320 biolink:NamedThing axial mesoderm formation The process that gives rise to the axial mesoderm. This process pertains to the initial formation of the structure from unspecified parts. RBO_relaxed.owl GO:0048341 biolink:NamedThing paraxial mesoderm formation The process that gives rise to the paraxial mesoderm. This process pertains to the initial formation of the structure from unspecified parts. RBO_relaxed.owl GO:0048370 biolink:NamedThing lateral mesoderm formation The process that gives rise to the lateral mesoderm. This process pertains to the initial formation of the structure from unspecified parts. RBO_relaxed.owl GO:0048391 biolink:NamedThing intermediate mesoderm formation The process that gives rise to the intermediate mesoderm. This process pertains to the initial formation of the structure from unspecified parts. RBO_relaxed.owl GO:0048645 biolink:NamedThing animal organ formation The process pertaining to the initial formation of an animal organ from unspecified parts. The process begins with the specific processes that contribute to the appearance of the discrete structure, such as inductive events, and ends when the structural rudiment of the organ is recognizable, such as a condensation of mesenchymal cells into the organ rudiment. Organs are a natural part or structure in an animal or a plant, capable of performing some special action (termed its function), which is essential to the life or well-being of the whole. The heart and lungs are organs of animals, and the petal and leaf are organs of plants. In animals the organs are generally made up of several tissues, one of which usually predominates, and determines the principal function of the organ. RBO_relaxed.owl GO:0048859 biolink:NamedThing formation of anatomical boundary The process in which the limits of an anatomical structure are generated. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome. RBO_relaxed.owl GO:0060214 biolink:NamedThing endocardium formation Formation of the endocardium of the heart. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers. RBO_relaxed.owl GO:0060343 biolink:NamedThing trabecula formation The process of creating a trabecula in an organ. A trabecula is a small, often microscopic, tissue element in the form of a small beam, strut or rod, which generally has a mechanical function. Trabecula are usually but not necessarily, composed of dense collagenous tissue. RBO_relaxed.owl GO:0060344 biolink:NamedThing liver trabecula formation The process of creating a trabecula in the liver. A trabecula is a tissue element in the form of a small beam, strut or rod. RBO_relaxed.owl GO:0060345 biolink:NamedThing spleen trabecula formation The process of creating a trabecula in the spleen. A trabecula is a tissue element in the form of a small beam, strut or rod. RBO_relaxed.owl GO:0060347 biolink:NamedThing heart trabecula formation The process of creating a trabecula in the heart. A trabecula is a tissue element in the form of a small beam, strut or rod. RBO_relaxed.owl GO:0060431 biolink:NamedThing primary lung bud formation The morphogenetic process in which the foregut region specified to become the lung forms the initial left and right buds. RBO_relaxed.owl GO:0060440 biolink:NamedThing trachea formation The process pertaining to the initial formation of a trachea from unspecified parts. The process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the trachea is recognizable. The trachea is the portion of the airway that attaches to the bronchi as it branches. RBO_relaxed.owl GO:0060464 biolink:NamedThing lung lobe formation The developmental process pertaining to the initial formation of a lung lobe from unspecified parts. This process begins with the specific processes that contribute to the appearance of the lobe and ends when the structural rudiment is recognizable. A lung lobe is a projection that extends from the lung. RBO_relaxed.owl GO:0060788 biolink:NamedThing ectodermal placode formation The developmental process in which an ectodermal placode forms. An ectodermal placode is a thickening of the ectoderm that is the primordium of many structures derived from the ectoderm. RBO_relaxed.owl GO:0060900 biolink:NamedThing embryonic camera-type eye formation The developmental process pertaining to the initial formation of a camera-type eye from unspecified neurectoderm. This process begins with the differentiation of cells that form the optic field and ends when the optic cup has attained its shape. RBO_relaxed.owl GO:0060914 biolink:NamedThing heart formation The developmental process pertaining to the initial formation of the heart from unspecified parts. This process begins with the specific processes that contribute to the appearance of the heart field and the arrival of cardiac neural crest to the heart region. The process ends when the structural rudiment is recognizable. RBO_relaxed.owl GO:0061130 biolink:NamedThing pancreatic bud formation The morphogenetic process in which the foregut region specified to become the pancreas forms a bud. RBO_relaxed.owl GO:0061554 biolink:NamedThing ganglion formation The process that gives rise to ganglion. This process pertains to the initial formation of a structure from unspecified parts. RBO_relaxed.owl GO:0061560 biolink:NamedThing cranial ganglion formation The process that gives rise to a cranial ganglion. This process pertains to the initial formation of a structure from unspecified parts. RBO_relaxed.owl GO:0061561 biolink:NamedThing trigeminal ganglion formation The process that gives rise to the trigeminal ganglion. This process pertains to the initial formation of a structure from unspecified parts. RBO_relaxed.owl GO:1905139 biolink:NamedThing apical ectodermal ridge formation The process that gives rise to the apical ectodermal ridge. This process pertains to the initial formation of a structure from unspecified parts. RBO_relaxed.owl GO:0001555 biolink:NamedThing oocyte growth The developmental growth process in which an oocyte irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present. RBO_relaxed.owl GO:0003006 biolink:NamedThing developmental process involved in reproduction A developmental process in which a progressive change in the state of some part of an organism, germline or somatic, specifically contributes to its ability to form offspring. RBO_relaxed.owl GO:0001556 biolink:NamedThing oocyte maturation A developmental process, independent of morphogenetic (shape) change, that is required for an oocyte to attain its fully functional state. Oocyte maturation commences after reinitiation of meiosis commonly starting with germinal vesicle breakdown, and continues up to the second meiotic arrest prior to fertilization. RBO_relaxed.owl GO:0007281 biolink:NamedThing germ cell development The process whose specific outcome is the progression of an immature germ cell over time, from its formation to the mature structure (gamete). A germ cell is any reproductive cell in a multicellular organism. RBO_relaxed.owl GO:0007308 biolink:NamedThing oocyte construction The synthesis, deposition, and organization of the materials in a cell of an ovary; where the cell can then undergo meiosis and form an ovum. An example of this is found in Drosophila melanogaster. RBO_relaxed.owl GO:0007548 biolink:NamedThing sex differentiation The establishment of the sex of an organism by physical differentiation. RBO_relaxed.owl GO:0009994 biolink:NamedThing oocyte differentiation The process in which a relatively unspecialized immature germ cell acquires the specialized features of a mature female gamete. RBO_relaxed.owl GO:0035234 biolink:NamedThing ectopic germ cell programmed cell death Programmed cell death of an errant germ line cell that is outside the normal migratory path or ectopic to the gonad. This is an important mechanism of regulating germ cell survival within the embryo. RBO_relaxed.owl GO:0045137 biolink:NamedThing development of primary sexual characteristics The process whose specific outcome is the progression of the primary sexual characteristics over time, from their formation to the mature structures. The primary sexual characteristics are the testes in males and the ovaries in females and they develop in response to sex hormone secretion. RBO_relaxed.owl GO:0022412 biolink:NamedThing cellular process involved in reproduction in multicellular organism A process, occurring at the cellular level, that is involved in the reproductive function of a multicellular organism. RBO_relaxed.owl GO:0007143 biolink:NamedThing female meiotic nuclear division A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the female germline. RBO_relaxed.owl GO:0030720 biolink:NamedThing oocyte localization involved in germarium-derived egg chamber formation Directed movement of the oocyte, following its specification, from its original central position in the cyst to a posterior position relative to the nurse cells of the egg chamber, and its maintenance in this posterior location. This is the first sign of anterior-posterior asymmetry in the developing egg chamber. RBO_relaxed.owl GO:0036093 biolink:NamedThing germ cell proliferation The multiplication or reproduction of germ cells, reproductive cells in multicellular organisms, resulting in the expansion of a cell population. RBO_relaxed.owl GO:0042078 biolink:NamedThing germ-line stem cell division The self-renewing division of a germline stem cell to produce a daughter stem cell and a daughter germ cell, which will divide to form the gametes. RBO_relaxed.owl GO:1903537 biolink:NamedThing meiotic cell cycle process involved in oocyte maturation Any meiotic cell cycle process that is involved in oocyte maturation. RBO_relaxed.owl GO:0001832 biolink:NamedThing blastocyst growth An increase in size of a blastocyst due to expansion of the blastocoelic cavity cell shape changes and cell proliferation. RBO_relaxed.owl GO:0003241 biolink:NamedThing growth involved in heart morphogenesis Developmental growth that contributes to the shaping of the heart. RBO_relaxed.owl GO:0016049 biolink:NamedThing cell growth The process in which a cell irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present. RBO_relaxed.owl GO:0042065 biolink:NamedThing glial cell growth Growth of glial cells, non-neuronal cells that provide support and nutrition, maintain homeostasis, form myelin, and participate in signal transmission in the nervous system. RBO_relaxed.owl GO:0048589 biolink:NamedThing developmental growth The increase in size or mass of an entire organism, a part of an organism or a cell, where the increase in size or mass has the specific outcome of the progression of the organism over time from one condition to another. RBO_relaxed.owl GO:0048588 biolink:NamedThing developmental cell growth The growth of a cell, where growth contributes to the progression of the cell over time from one condition to another. RBO_relaxed.owl GO:0061049 biolink:NamedThing cell growth involved in cardiac muscle cell development The growth of a cardiac muscle cell, where growth contributes to the progression of the cell over time from its initial formation to its mature state. RBO_relaxed.owl GO:0021700 biolink:NamedThing developmental maturation A developmental process, independent of morphogenetic (shape) change, that is required for an anatomical structure, cell or cellular component to attain its fully functional state. RBO_relaxed.owl GO:0001955 biolink:NamedThing blood vessel maturation A developmental process, independent of morphogenetic (shape) change, that is required for a blood vessel to attain its fully functional state. RBO_relaxed.owl GO:0002069 biolink:NamedThing columnar/cuboidal epithelial cell maturation The developmental process, independent of morphogenetic (shape) change, that is required for a columna/cuboidal epithelial cell to attain its fully functional state. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube. RBO_relaxed.owl GO:0002070 biolink:NamedThing epithelial cell maturation The developmental process, independent of morphogenetic (shape) change, that is required for an epithelial cell to attain its fully functional state. An epithelial cell is a cell usually found in a two-dimensional sheet with a free surface. RBO_relaxed.owl GO:0002071 biolink:NamedThing glandular epithelial cell maturation The developmental process, independent of morphogenetic (shape) change, that is required for a glandular epithelial cell to attain its fully functional state. A glandular epithelial cell is a columnar/cuboidal epithelial cell is a cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland. RBO_relaxed.owl GO:0021578 biolink:NamedThing hindbrain maturation A developmental process, independent of morphogenetic (shape) change, that is required for the hindbrain to attain its fully functional state. The hindbrain is the region consisting of the medulla, pons and cerebellum. Areas of the hindbrain control motor and autonomic functions. RBO_relaxed.owl GO:0021582 biolink:NamedThing medulla oblongata maturation A developmental process, independent of morphogenetic (shape) change, that is required for the medulla oblongata to attain its fully functional state. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate. RBO_relaxed.owl GO:0021586 biolink:NamedThing pons maturation A developmental process, independent of morphogenetic (shape) change, that is required for the pons to attain its fully functional state. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum. RBO_relaxed.owl GO:0021605 biolink:NamedThing cranial nerve maturation A developmental process, independent of morphogenetic (shape) change, that is required for a cranial nerve to attain its fully functional state. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions. RBO_relaxed.owl GO:0021626 biolink:NamedThing central nervous system maturation A developmental process, independent of morphogenetic (shape) change, that is required for the central nervous system to attain its fully functional state. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord. RBO_relaxed.owl GO:0021635 biolink:NamedThing trigeminal nerve maturation A developmental process, independent of morphogenetic (shape) change, that is required for the trigeminal nerve to attain its fully functional state. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae. RBO_relaxed.owl GO:0021682 biolink:NamedThing nerve maturation A developmental process, independent of morphogenetic (shape) change, that is required for a nerve to attain its fully functional state. RBO_relaxed.owl GO:0021706 biolink:NamedThing locus ceruleus maturation A developmental process, independent of morphogenetic (shape) change, that is required for the locus ceruleus to attain its fully functional state. The locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic. RBO_relaxed.owl GO:0021722 biolink:NamedThing superior olivary nucleus maturation A developmental process, independent of morphogenetic (shape) change, that is required for the superior olivary nucleus to attain its fully functional state. The superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound. RBO_relaxed.owl GO:0021732 biolink:NamedThing midbrain-hindbrain boundary maturation A developmental process, independent of morphogenetic (shape) change, that is required for the midbrain-hindbrain boundary to attain its fully functional state. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate. RBO_relaxed.owl GO:0042551 biolink:NamedThing neuron maturation A developmental process, independent of morphogenetic (shape) change, that is required for a neuron to attain its fully functional state. RBO_relaxed.owl GO:0043249 biolink:NamedThing erythrocyte maturation A developmental process, independent of morphogenetic (shape) change, that is required for an erythrocyte to attain its fully functional state. RBO_relaxed.owl GO:0043354 biolink:NamedThing enucleate erythrocyte maturation A developmental process, independent of morphogenetic (shape) change, that is required for an enucleate erythrocyte to attain its fully functional state. An enucleate erythrocyte is an erythrocyte without a nucleus. RBO_relaxed.owl GO:0043362 biolink:NamedThing nucleate erythrocyte maturation A developmental process, independent of morphogenetic (shape) change, that is required for a nucleate erythrocyte to attain its fully functional state. A nucleate erythrocyte is an erythrocyte with a nucleus. RBO_relaxed.owl GO:0048469 biolink:NamedThing cell maturation The cellular developmental process, independent of morphogenetic (shape) change, that is required for a specific cell to attain its fully functional state. RBO_relaxed.owl GO:0048628 biolink:NamedThing myoblast maturation A developmental process, independent of morphogenetic (shape) change, that is required for a myoblast to attain its fully functional state. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. RBO_relaxed.owl GO:0048799 biolink:NamedThing animal organ maturation A developmental process, independent of morphogenetic (shape) change, that is required for an animal organ to attain its fully functional state. An organ is a tissue or set of tissues that work together to perform a specific function or functions. RBO_relaxed.owl GO:0060574 biolink:NamedThing intestinal epithelial cell maturation The developmental process, independent of morphogenetic (shape) change, that is required for a columna/cuboidal epithelial cell of the intestine to attain its fully functional state. A columnar/cuboidal epithelial cell of the intestine mature as they migrate from the intestinal crypt to the villus. RBO_relaxed.owl GO:0061792 biolink:NamedThing secretory granule maturation Steps required to transform an immature secretory vesicle into a mature secretory vesicle. Typically proceeds through homotypic membrane fusion and membrane remodeling. RBO_relaxed.owl GO:0070977 biolink:NamedThing bone maturation A developmental process, independent of morphogenetic (shape) change, that is required for bone to attain its fully functional state. RBO_relaxed.owl GO:0071695 biolink:NamedThing anatomical structure maturation A developmental process, independent of morphogenetic (shape) change, that is required for an anatomical structure to attain its fully functional state. RBO_relaxed.owl GO:0072560 biolink:NamedThing type B pancreatic cell maturation A developmental process, independent of morphogenetic (shape) change, that is required for a type B pancreatic cell to attain its fully functional state. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin. RBO_relaxed.owl GO:1990502 biolink:NamedThing dense core granule maturation Steps required to transform a dense core granule generated at the trans-Golgi network into a fully formed and transmissible dense core granule. Dense core granule maturation proceeds through clathrin-mediated membrane remodeling events and is essential for efficient processing of cargo within dense core granules as well as for removing factors that might otherwise interfere with dense core granule trafficking and exocytosis. RBO_relaxed.owl GO:0001558 biolink:NamedThing regulation of cell growth Any process that modulates the frequency, rate, extent or direction of cell growth. RBO_relaxed.owl GO:0040008 biolink:NamedThing regulation of growth Any process that modulates the frequency, rate or extent of the growth of all or part of an organism so that it occurs at its proper speed, either globally or in a specific part of the organism's development. RBO_relaxed.owl GO:0045926 biolink:NamedThing negative regulation of growth Any process that stops, prevents or reduces the rate or extent of growth, the increase in size or mass of all or part of an organism. RBO_relaxed.owl GO:0045927 biolink:NamedThing positive regulation of growth Any process that activates or increases the rate or extent of growth, the increase in size or mass of all or part of an organism. RBO_relaxed.owl GO:0048638 biolink:NamedThing regulation of developmental growth Any process that modulates the frequency, rate or extent of developmental growth. RBO_relaxed.owl GO:0051128 biolink:NamedThing regulation of cellular component organization Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope. RBO_relaxed.owl GO:0010549 biolink:NamedThing regulation of membrane disassembly Any process that modulates the frequency, rate or extent of membrane disassembly. RBO_relaxed.owl GO:0031344 biolink:NamedThing regulation of cell projection organization Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell projections. RBO_relaxed.owl GO:0033043 biolink:NamedThing regulation of organelle organization Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle. RBO_relaxed.owl GO:0043244 biolink:NamedThing regulation of protein-containing complex disassembly Any process that modulates the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components. RBO_relaxed.owl GO:0043254 biolink:NamedThing regulation of protein-containing complex assembly Any process that modulates the frequency, rate or extent of protein complex assembly. RBO_relaxed.owl GO:0050807 biolink:NamedThing regulation of synapse organization Any process that modulates the physical form of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell). RBO_relaxed.owl GO:0051129 biolink:NamedThing negative regulation of cellular component organization Any process that stops, prevents, or reduces the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope. RBO_relaxed.owl GO:0051130 biolink:NamedThing positive regulation of cellular component organization Any process that activates or increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope. RBO_relaxed.owl GO:0060142 biolink:NamedThing regulation of syncytium formation by plasma membrane fusion Any process that modulates the frequency, rate or extent of the formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells. RBO_relaxed.owl GO:1901888 biolink:NamedThing regulation of cell junction assembly Any process that modulates the frequency, rate or extent of cell junction assembly. RBO_relaxed.owl GO:1902275 biolink:NamedThing regulation of chromatin organization Any process that modulates the frequency, rate or extent of chromatin organization. RBO_relaxed.owl GO:1902903 biolink:NamedThing regulation of supramolecular fiber organization Any process that modulates the frequency, rate or extent of supramolecular fiber organization. RBO_relaxed.owl GO:1903053 biolink:NamedThing regulation of extracellular matrix organization Any process that modulates the frequency, rate or extent of extracellular matrix organization. RBO_relaxed.owl GO:1903729 biolink:NamedThing regulation of plasma membrane organization Any process that modulates the frequency, rate or extent of plasma membrane organization. RBO_relaxed.owl GO:0001936 biolink:NamedThing regulation of endothelial cell proliferation Any process that modulates the frequency, rate, or extent of endothelial cell proliferation. RBO_relaxed.owl GO:0001937 biolink:NamedThing negative regulation of endothelial cell proliferation Any process that stops, prevents, or reduces the rate or extent of endothelial cell proliferation. RBO_relaxed.owl GO:0001938 biolink:NamedThing positive regulation of endothelial cell proliferation Any process that activates or increases the rate or extent of endothelial cell proliferation. RBO_relaxed.owl GO:0001956 biolink:NamedThing positive regulation of neurotransmitter secretion Any process that activates or increases the frequency, rate or extent of the regulated release of a neurotransmitter. RBO_relaxed.owl GO:0002028 biolink:NamedThing regulation of sodium ion transport Any process that modulates the frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. RBO_relaxed.owl GO:0002052 biolink:NamedThing positive regulation of neuroblast proliferation Any process that activates or increases the rate of neuroblast proliferation. RBO_relaxed.owl GO:0002053 biolink:NamedThing positive regulation of mesenchymal cell proliferation The process of activating or increasing the rate or extent of mesenchymal cell proliferation. Mesenchymal cells are loosely organized embryonic cells. RBO_relaxed.owl GO:0002085 biolink:NamedThing inhibition of neuroepithelial cell differentiation Any process that prevents the activation of neuroepithelial cell differentiation. Neuroepithelial cell differentiation is the process in which epiblast cells acquire specialized features of neuroepithelial cells. RBO_relaxed.owl GO:0002682 biolink:NamedThing regulation of immune system process Any process that modulates the frequency, rate, or extent of an immune system process. RBO_relaxed.owl GO:0002683 biolink:NamedThing negative regulation of immune system process Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune system process. RBO_relaxed.owl GO:0002684 biolink:NamedThing positive regulation of immune system process Any process that activates or increases the frequency, rate, or extent of an immune system process. RBO_relaxed.owl GO:0002697 biolink:NamedThing regulation of immune effector process Any process that modulates the frequency, rate, or extent of an immune effector process. RBO_relaxed.owl GO:0002698 biolink:NamedThing negative regulation of immune effector process Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune effector process. RBO_relaxed.owl GO:0002699 biolink:NamedThing positive regulation of immune effector process Any process that activates or increases the frequency, rate, or extent of an immune effector process. RBO_relaxed.owl GO:0002703 biolink:NamedThing regulation of leukocyte mediated immunity Any process that modulates the frequency, rate, or extent of leukocyte mediated immunity. RBO_relaxed.owl GO:0002704 biolink:NamedThing negative regulation of leukocyte mediated immunity Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte mediated immunity. RBO_relaxed.owl GO:0002705 biolink:NamedThing positive regulation of leukocyte mediated immunity Any process that activates or increases the frequency, rate, or extent of leukocyte mediated immunity. RBO_relaxed.owl GO:0002761 biolink:NamedThing regulation of myeloid leukocyte differentiation Any process that modulates the frequency, rate, or extent of myeloid leukocyte differentiation. RBO_relaxed.owl GO:0002762 biolink:NamedThing negative regulation of myeloid leukocyte differentiation Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid leukocyte differentiation. RBO_relaxed.owl GO:0002763 biolink:NamedThing positive regulation of myeloid leukocyte differentiation Any process that activates or increases the frequency, rate, or extent of myeloid leukocyte differentiation. RBO_relaxed.owl GO:0002791 biolink:NamedThing regulation of peptide secretion Any process that modulates the frequency, rate, or extent of peptide secretion. RBO_relaxed.owl GO:0002792 biolink:NamedThing negative regulation of peptide secretion Any process that stops, prevents, or reduces the frequency, rate, or extent of peptide secretion. RBO_relaxed.owl GO:0002793 biolink:NamedThing positive regulation of peptide secretion Any process that activates or increases the frequency, rate, or extent of peptide secretion. RBO_relaxed.owl GO:0002831 biolink:NamedThing regulation of response to biotic stimulus Any process that modulates the frequency, rate, or extent of a response to biotic stimulus. RBO_relaxed.owl GO:0002832 biolink:NamedThing negative regulation of response to biotic stimulus Any process that stops, prevents, or reduces the frequency, rate, or extent of a response to biotic stimulus. RBO_relaxed.owl GO:0002833 biolink:NamedThing positive regulation of response to biotic stimulus Any process that activates or increases the frequency, rate, or extent of a response to biotic stimulus. RBO_relaxed.owl GO:0002886 biolink:NamedThing regulation of myeloid leukocyte mediated immunity Any process that modulates the frequency, rate, or extent of myeloid leukocyte mediated immunity. RBO_relaxed.owl GO:0002887 biolink:NamedThing negative regulation of myeloid leukocyte mediated immunity Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid leukocyte mediated immunity. RBO_relaxed.owl GO:0002888 biolink:NamedThing positive regulation of myeloid leukocyte mediated immunity Any process that activates or increases the frequency, rate, or extent of myeloid leukocyte mediated immunity. RBO_relaxed.owl GO:0003156 biolink:NamedThing regulation of animal organ formation Any process that modulates the rate, frequency or extent of animal organ formation. Organ formation is the process pertaining to the initial formation of an organ from unspecified parts. The process begins with the specific processes that contribute to the appearance of the discrete structure, such as inductive events, and ends when the structural rudiment of the organ is recognizable, such as a condensation of mesenchymal cells into the organ rudiment. RBO_relaxed.owl GO:0005979 biolink:NamedThing regulation of glycogen biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen. RBO_relaxed.owl GO:0005981 biolink:NamedThing regulation of glycogen catabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glycogen. RBO_relaxed.owl GO:0006109 biolink:NamedThing regulation of carbohydrate metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving carbohydrates. RBO_relaxed.owl GO:0006111 biolink:NamedThing regulation of gluconeogenesis Any process that modulates the frequency, rate or extent of gluconeogenesis, the formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol. RBO_relaxed.owl GO:0006282 biolink:NamedThing regulation of DNA repair Any process that modulates the frequency, rate or extent of DNA repair. RBO_relaxed.owl GO:0006417 biolink:NamedThing regulation of translation Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA. RBO_relaxed.owl GO:0006446 biolink:NamedThing regulation of translational initiation Any process that modulates the frequency, rate or extent of translational initiation. RBO_relaxed.owl GO:0006448 biolink:NamedThing regulation of translational elongation Any process that modulates the frequency, rate, extent or accuracy of translational elongation. RBO_relaxed.owl GO:0006449 biolink:NamedThing regulation of translational termination Any process that modulates the frequency, rate or extent of translational termination. RBO_relaxed.owl GO:0006521 biolink:NamedThing regulation of cellular amino acid metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving amino acids. RBO_relaxed.owl GO:0006937 biolink:NamedThing regulation of muscle contraction Any process that modulates the frequency, rate or extent of muscle contraction. RBO_relaxed.owl GO:0006940 biolink:NamedThing regulation of smooth muscle contraction Any process that modulates the frequency, rate or extent of smooth muscle contraction. RBO_relaxed.owl GO:0006942 biolink:NamedThing regulation of striated muscle contraction Any process that modulates the frequency, rate or extent of striated muscle contraction. RBO_relaxed.owl GO:0007026 biolink:NamedThing negative regulation of microtubule depolymerization Any process that stops, prevents, or reduces the frequency, rate or extent of microtubule depolymerization; prevention of depolymerization of a microtubule can result from binding by 'capping' at the plus end (e.g. by interaction with another cellular protein of structure) or by exposing microtubules to a stabilizing drug such as taxol. RBO_relaxed.owl GO:0007027 biolink:NamedThing negative regulation of axonemal microtubule depolymerization Any process that stops, prevents, or reduces the frequency, rate or extent of the depolymerization of the specialized microtubules of the axoneme. RBO_relaxed.owl GO:0007088 biolink:NamedThing regulation of mitotic nuclear division Any process that modulates the frequency, rate or extent of mitosis. RBO_relaxed.owl GO:0007346 biolink:NamedThing regulation of mitotic cell cycle Any process that modulates the rate or extent of progress through the mitotic cell cycle. RBO_relaxed.owl GO:0007406 biolink:NamedThing negative regulation of neuroblast proliferation Any process that stops, prevents, or reduces the frequency, rate or extent of the proliferation of neuroblasts. RBO_relaxed.owl GO:0008016 biolink:NamedThing regulation of heart contraction Any process that modulates the frequency, rate or extent of heart contraction. Heart contraction is the process in which the heart decreases in volume in a characteristic way to propel blood through the body. RBO_relaxed.owl GO:0008284 biolink:NamedThing positive regulation of cell population proliferation Any process that activates or increases the rate or extent of cell proliferation. RBO_relaxed.owl GO:0008285 biolink:NamedThing negative regulation of cell population proliferation Any process that stops, prevents or reduces the rate or extent of cell proliferation. RBO_relaxed.owl GO:0009786 biolink:NamedThing regulation of asymmetric cell division Any process that modulates the frequency, rate or extent of asymmetric cell division. RBO_relaxed.owl GO:0009889 biolink:NamedThing regulation of biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances. RBO_relaxed.owl GO:0009890 biolink:NamedThing negative regulation of biosynthetic process Any process that stops, prevents, or reduces the rate of the chemical reactions and pathways resulting in the formation of substances. RBO_relaxed.owl GO:0009891 biolink:NamedThing positive regulation of biosynthetic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances. RBO_relaxed.owl GO:0009892 biolink:NamedThing negative regulation of metabolic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism. RBO_relaxed.owl GO:0009893 biolink:NamedThing positive regulation of metabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism. RBO_relaxed.owl GO:0009894 biolink:NamedThing regulation of catabolic process Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of substances. RBO_relaxed.owl GO:0009895 biolink:NamedThing negative regulation of catabolic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances. RBO_relaxed.owl GO:0009896 biolink:NamedThing positive regulation of catabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances. RBO_relaxed.owl GO:0009966 biolink:NamedThing regulation of signal transduction Any process that modulates the frequency, rate or extent of signal transduction. RBO_relaxed.owl GO:0009967 biolink:NamedThing positive regulation of signal transduction Any process that activates or increases the frequency, rate or extent of signal transduction. RBO_relaxed.owl GO:0009968 biolink:NamedThing negative regulation of signal transduction Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction. RBO_relaxed.owl GO:0010453 biolink:NamedThing regulation of cell fate commitment Any process that modulates the frequency, rate or extent of cell fate commitment. Cell fate commitment is the commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field. RBO_relaxed.owl GO:0010454 biolink:NamedThing negative regulation of cell fate commitment Any process that stops, prevents or reduces the frequency or rate of cell fate commitment. Cell fate commitment is the commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field. RBO_relaxed.owl GO:0010455 biolink:NamedThing positive regulation of cell fate commitment Any process that activates, maintains or increases the frequency or rate of cell fate commitment. Cell fate commitment is the commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field. RBO_relaxed.owl GO:0010464 biolink:NamedThing regulation of mesenchymal cell proliferation Any process that modulates the frequency, rate or extent of mesenchymal cell proliferation. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets. RBO_relaxed.owl GO:0010468 biolink:NamedThing regulation of gene expression Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). RBO_relaxed.owl GO:0010470 biolink:NamedThing regulation of gastrulation Any process that modulates the rate or extent of gastrulation. Gastrulation is the complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. RBO_relaxed.owl GO:0010482 biolink:NamedThing regulation of epidermal cell division Any process that modulates the frequency, rate or extent of the physical partitioning and separation of an epidermal cell into daughter cells. An epidermal cell is any of the cells that make up the epidermis. RBO_relaxed.owl GO:0010556 biolink:NamedThing regulation of macromolecule biosynthetic process Any process that modulates the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. RBO_relaxed.owl GO:0010557 biolink:NamedThing positive regulation of macromolecule biosynthetic process Any process that increases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. RBO_relaxed.owl GO:0010558 biolink:NamedThing negative regulation of macromolecule biosynthetic process Any process that decreases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. RBO_relaxed.owl GO:0010559 biolink:NamedThing regulation of glycoprotein biosynthetic process Any process that modulates the rate, frequency, or extent of the chemical reactions and pathways resulting in the formation of a glycoprotein, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide. RBO_relaxed.owl GO:0010560 biolink:NamedThing positive regulation of glycoprotein biosynthetic process Any process that increases the rate, frequency, or extent of the chemical reactions and pathways resulting in the formation of a glycoprotein, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide. RBO_relaxed.owl GO:0010561 biolink:NamedThing negative regulation of glycoprotein biosynthetic process Any process that decreases the rate, frequency, or extent of the chemical reactions and pathways resulting in the formation of a glycoprotein, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide. RBO_relaxed.owl GO:0010562 biolink:NamedThing positive regulation of phosphorus metabolic process Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus. RBO_relaxed.owl GO:0010563 biolink:NamedThing negative regulation of phosphorus metabolic process Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus. RBO_relaxed.owl GO:0010564 biolink:NamedThing regulation of cell cycle process Any process that modulates a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. RBO_relaxed.owl GO:0010565 biolink:NamedThing regulation of cellular ketone metabolic process Any process that modulates the chemical reactions and pathways involving any of a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups. RBO_relaxed.owl GO:0010566 biolink:NamedThing regulation of ketone biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of a ketone, carried out by individual cells. RBO_relaxed.owl GO:0010567 biolink:NamedThing regulation of ketone catabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a ketone, carried out by individual cells. RBO_relaxed.owl GO:0010604 biolink:NamedThing positive regulation of macromolecule metabolic process Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. RBO_relaxed.owl GO:0010605 biolink:NamedThing negative regulation of macromolecule metabolic process Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. RBO_relaxed.owl GO:0010611 biolink:NamedThing regulation of cardiac muscle hypertrophy Any process that modulates the rate, frequency or extent of the enlargement or overgrowth of all or part of the heart due to an increase in size (not length) of individual cardiac muscle fibers, without cell division. RBO_relaxed.owl GO:0010612 biolink:NamedThing regulation of cardiac muscle adaptation Any process that modulates the rate, extent or frequency of the process in which cardiac muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. RBO_relaxed.owl GO:0010613 biolink:NamedThing positive regulation of cardiac muscle hypertrophy Any process that increases the rate, frequency or extent of the enlargement or overgrowth of all or part of the heart due to an increase in size (not length) of individual cardiac muscle fibers, without cell division. RBO_relaxed.owl GO:0010614 biolink:NamedThing negative regulation of cardiac muscle hypertrophy Any process that decreases the rate, frequency or extent of the enlargement or overgrowth of all or part of the heart due to an increase in size (not length) of individual cardiac muscle fibers, without cell division. RBO_relaxed.owl GO:0010615 biolink:NamedThing positive regulation of cardiac muscle adaptation Any process that increases the rate, extent or frequency of the process in which cardiac muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. RBO_relaxed.owl GO:0010616 biolink:NamedThing negative regulation of cardiac muscle adaptation Any process that decreases the rate, extent or frequency of the process in which cardiac muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. RBO_relaxed.owl GO:0010628 biolink:NamedThing positive regulation of gene expression Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). RBO_relaxed.owl GO:0010629 biolink:NamedThing negative regulation of gene expression Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). RBO_relaxed.owl GO:0010638 biolink:NamedThing positive regulation of organelle organization Any process that increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle. RBO_relaxed.owl GO:0010639 biolink:NamedThing negative regulation of organelle organization Any process that decreases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle. RBO_relaxed.owl GO:0010646 biolink:NamedThing regulation of cell communication Any process that modulates the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. RBO_relaxed.owl GO:0010647 biolink:NamedThing positive regulation of cell communication Any process that increases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. RBO_relaxed.owl GO:0010648 biolink:NamedThing negative regulation of cell communication Any process that decreases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. RBO_relaxed.owl GO:0010656 biolink:NamedThing negative regulation of muscle cell apoptotic process Any process that decreases the rate or frequency of muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a muscle cell and result in its death. RBO_relaxed.owl GO:0010660 biolink:NamedThing regulation of muscle cell apoptotic process Any process that modulates the rate or frequency of muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a muscle cell and result in its death. RBO_relaxed.owl GO:0010661 biolink:NamedThing positive regulation of muscle cell apoptotic process Any process that increases the rate or frequency of muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a muscle cell and result in its death. RBO_relaxed.owl GO:0010662 biolink:NamedThing regulation of striated muscle cell apoptotic process Any process that modulates the rate or extent of striated muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a striated muscle cell and result in its death. RBO_relaxed.owl GO:0010663 biolink:NamedThing positive regulation of striated muscle cell apoptotic process Any process that increases the rate or extent of striated muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a striated muscle cell and result in its death. RBO_relaxed.owl GO:0010664 biolink:NamedThing negative regulation of striated muscle cell apoptotic process Any process that decreases the rate or extent of striated muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a striated muscle cell and result in its death. RBO_relaxed.owl GO:0010665 biolink:NamedThing regulation of cardiac muscle cell apoptotic process Any process that modulates the rate or extent of cardiac cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a cardiac muscle cell and result in its death. RBO_relaxed.owl GO:0010666 biolink:NamedThing positive regulation of cardiac muscle cell apoptotic process Any process that increases the rate or extent of cardiac cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a cardiac muscle cell and result in its death. RBO_relaxed.owl GO:0010667 biolink:NamedThing negative regulation of cardiac muscle cell apoptotic process Any process that decreases the rate or extent of cardiac cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a cardiac muscle cell and result in its death. RBO_relaxed.owl GO:0010700 biolink:NamedThing negative regulation of norepinephrine secretion Any process that decreases the frequency, rate or extent of the regulated release of norepinephrine. RBO_relaxed.owl GO:0010701 biolink:NamedThing positive regulation of norepinephrine secretion Any process that increases the frequency, rate or extent of the regulated release of norepinephrine. RBO_relaxed.owl GO:0010710 biolink:NamedThing regulation of collagen catabolic process Any process that modulates the rate, frequency or extent of collagen catabolism. Collagen catabolism is the proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix. RBO_relaxed.owl GO:0010711 biolink:NamedThing negative regulation of collagen catabolic process Any process that decreases the rate, frequency or extent of collagen catabolism. Collagen catabolism is the proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix. RBO_relaxed.owl GO:0010712 biolink:NamedThing regulation of collagen metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the metabolism of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. RBO_relaxed.owl GO:0010713 biolink:NamedThing negative regulation of collagen metabolic process Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the metabolism of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. RBO_relaxed.owl GO:0010714 biolink:NamedThing positive regulation of collagen metabolic process Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the metabolism of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. RBO_relaxed.owl GO:0010715 biolink:NamedThing regulation of extracellular matrix disassembly Any process that modulates the rate, frequency or extent of extracellular matrix disassembly. Extracellular matrix disassembly is a process that results in the breakdown of the extracellular matrix. RBO_relaxed.owl GO:0010716 biolink:NamedThing negative regulation of extracellular matrix disassembly Any process that decreases the rate, frequency or extent of extracellular matrix disassembly. Extracellular matrix disassembly is a process that results in the breakdown of the extracellular matrix. RBO_relaxed.owl GO:0010717 biolink:NamedThing regulation of epithelial to mesenchymal transition Any process that modulates the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. RBO_relaxed.owl GO:0010718 biolink:NamedThing positive regulation of epithelial to mesenchymal transition Any process that increases the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition is where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. RBO_relaxed.owl GO:0010719 biolink:NamedThing negative regulation of epithelial to mesenchymal transition Any process that decreases the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. RBO_relaxed.owl GO:0010720 biolink:NamedThing positive regulation of cell development Any process that increases the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate. RBO_relaxed.owl GO:0010721 biolink:NamedThing negative regulation of cell development Any process that decreases the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate. RBO_relaxed.owl GO:0010765 biolink:NamedThing positive regulation of sodium ion transport Any process that increases the frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. RBO_relaxed.owl GO:0010766 biolink:NamedThing negative regulation of sodium ion transport Any process that decreases the frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. RBO_relaxed.owl GO:0010770 biolink:NamedThing positive regulation of cell morphogenesis Any process that increases the frequency, rate or extent of cell morphogenesis contributing to cell differentiation. Cell morphogenesis involved in differentiation is the change in form (cell shape and size) that occurs when relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. RBO_relaxed.owl GO:0010771 biolink:NamedThing negative regulation of cell morphogenesis Any process that decreases the frequency, rate or extent of cell morphogenesis contributing to cell differentiation. Cell morphogenesis involved in differentiation is the change in form (cell shape and size) that occurs when relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. RBO_relaxed.owl GO:0010827 biolink:NamedThing regulation of glucose transmembrane transport Any process that modulates the frequency, rate or extent of glucose transport across a membrane. Glucose transport is the directed movement of the hexose monosaccharide glucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. RBO_relaxed.owl GO:0010828 biolink:NamedThing positive regulation of glucose transmembrane transport Any process that increases the frequency, rate or extent of glucose transport across a membrane. Glucose transport is the directed movement of the hexose monosaccharide glucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. RBO_relaxed.owl GO:0010829 biolink:NamedThing negative regulation of glucose transmembrane transport Any process that decreases the frequency, rate or extent of glucose transport across a membrane. Glucose transport is the directed movement of the hexose monosaccharide glucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. RBO_relaxed.owl GO:0010830 biolink:NamedThing regulation of myotube differentiation Any process that modulates the frequency, rate or extent of myotube differentiation. Myotube differentiation is the process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse. RBO_relaxed.owl GO:0010831 biolink:NamedThing positive regulation of myotube differentiation Any process that activates, maintains or increases the frequency, rate or extent of myotube differentiation. Myotube differentiation is the process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse. RBO_relaxed.owl GO:0010832 biolink:NamedThing negative regulation of myotube differentiation Any process that decreases the frequency, rate or extent of myotube differentiation. Myotube differentiation is the process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse. RBO_relaxed.owl GO:0010893 biolink:NamedThing positive regulation of steroid biosynthetic process Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus. RBO_relaxed.owl GO:0010894 biolink:NamedThing negative regulation of steroid biosynthetic process Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus. RBO_relaxed.owl GO:0010906 biolink:NamedThing regulation of glucose metabolic process Any process that modulates the rate, frequency or extent of glucose metabolism. Glucose metabolic processes are the chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. RBO_relaxed.owl GO:0010907 biolink:NamedThing positive regulation of glucose metabolic process Any process that increases the rate, frequency or extent of glucose metabolism. Glucose metabolic processes are the chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. RBO_relaxed.owl GO:0010937 biolink:NamedThing regulation of cytoplasmic microtubule depolymerization Any process that modulates the frequency, rate or extent of cytoplasmic microtubule depolymerization. RBO_relaxed.owl GO:0010948 biolink:NamedThing negative regulation of cell cycle process Any process that decreases the rate, frequency or extent of a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. RBO_relaxed.owl GO:0010959 biolink:NamedThing regulation of metal ion transport Any process that modulates the frequency, rate, or extent of metal ion transport. Metal ion transport is the directed movement of metal ions, any metal ion with an electric charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. RBO_relaxed.owl GO:0010962 biolink:NamedThing regulation of glucan biosynthetic process Any process that modulates the rate, frequency, or extent of glucan biosynthesis. Glucan biosynthetic processes are the chemical reactions and pathways resulting in the formation of glucans, polysaccharides consisting only of glucose residues. RBO_relaxed.owl GO:0010966 biolink:NamedThing regulation of phosphate transport Any process that modulates the frequency, rate or extent of phosphate transport. Phosphate transport is the directed movement of phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. RBO_relaxed.owl GO:0010968 biolink:NamedThing regulation of microtubule nucleation Any process that modulates the rate, frequency or extent of microtubule nucleation. Microtubule nucleation is the 'de novo' formation of a microtubule, in which tubulin heterodimers form metastable oligomeric aggregates, some of which go on to support formation of a complete microtubule. Microtubule nucleation usually occurs from a specific site within a cell. RBO_relaxed.owl GO:0010975 biolink:NamedThing regulation of neuron projection development Any process that modulates the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites). RBO_relaxed.owl GO:0010976 biolink:NamedThing positive regulation of neuron projection development Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites). RBO_relaxed.owl GO:0010977 biolink:NamedThing negative regulation of neuron projection development Any process that decreases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites). RBO_relaxed.owl GO:0014013 biolink:NamedThing regulation of gliogenesis Any process that modulates the frequency, rate or extent of gliogenesis, the formation of mature glia. RBO_relaxed.owl GO:0014014 biolink:NamedThing negative regulation of gliogenesis Any process that stops, prevents, or reduces the frequency, rate or extent of gliogenesis, the formation of mature glia. RBO_relaxed.owl GO:0014015 biolink:NamedThing positive regulation of gliogenesis Any process that activates or increases the frequency, rate or extent of gliogenesis, the formation of mature glia. RBO_relaxed.owl GO:0014041 biolink:NamedThing regulation of neuron maturation Any process that modulates the frequency, rate or extent of neuron maturation, the process leading to the attainment of the full functional capacity of a neuron. This process is independent of morphogenetic change. RBO_relaxed.owl GO:0014042 biolink:NamedThing positive regulation of neuron maturation Any process that activates or increases the frequency, rate or extent of neuron maturation. RBO_relaxed.owl GO:0014043 biolink:NamedThing negative regulation of neuron maturation Any process that stops, prevents, or reduces the frequency, rate or extent of neuron maturation. RBO_relaxed.owl GO:0014056 biolink:NamedThing regulation of acetylcholine secretion, neurotransmission Any process that modulates the frequency, rate or extent of the regulated release of acetylcholine. RBO_relaxed.owl GO:0014057 biolink:NamedThing positive regulation of acetylcholine secretion, neurotransmission Any process that activates or increases the frequency, rate or extent of the regulated release of acetylcholine. RBO_relaxed.owl GO:0014058 biolink:NamedThing negative regulation of acetylcholine secretion, neurotransmission Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of acetylcholine. RBO_relaxed.owl GO:0014061 biolink:NamedThing regulation of norepinephrine secretion Any process that modulates the frequency, rate or extent of the regulated release of norepinephrine. RBO_relaxed.owl GO:0014062 biolink:NamedThing regulation of serotonin secretion Any process that modulates the frequency, rate or extent of the regulated release of serotonin. RBO_relaxed.owl GO:0014063 biolink:NamedThing negative regulation of serotonin secretion Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of serotonin. RBO_relaxed.owl GO:0014064 biolink:NamedThing positive regulation of serotonin secretion Any process that activates or increases the frequency, rate or extent of the regulated release of serotonin. RBO_relaxed.owl GO:0014733 biolink:NamedThing regulation of skeletal muscle adaptation Any process in which skeletal muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities. RBO_relaxed.owl GO:0014741 biolink:NamedThing negative regulation of muscle hypertrophy Any process that stops, prevents, or reduces the frequency, rate, or extent of muscle hypertrophy. RBO_relaxed.owl GO:0014742 biolink:NamedThing positive regulation of muscle hypertrophy Any process that activates or increases the frequency, rate or extent of muscle hypertrophy. RBO_relaxed.owl GO:0014743 biolink:NamedThing regulation of muscle hypertrophy Any process that modulates the frequency, rate or extent of muscle hypertrophy. RBO_relaxed.owl GO:0014744 biolink:NamedThing positive regulation of muscle adaptation Any process that activates or increases the frequency, rate or extent of muscle adaptation. RBO_relaxed.owl GO:0014745 biolink:NamedThing negative regulation of muscle adaptation Any process that stops, prevents, or reduces the frequency, rate, or extent of muscle adaptation. RBO_relaxed.owl GO:0014807 biolink:NamedThing regulation of somitogenesis Any process that modulates the frequency, rate or extent of somitogenesis. RBO_relaxed.owl GO:0014819 biolink:NamedThing regulation of skeletal muscle contraction Any process that modulates the frequency, rate or extent of skeletal muscle contraction. RBO_relaxed.owl GO:0014857 biolink:NamedThing regulation of skeletal muscle cell proliferation Any process that modulates the frequency, rate or extent of skeletal muscle cell proliferation. RBO_relaxed.owl GO:0014858 biolink:NamedThing positive regulation of skeletal muscle cell proliferation Any process that activates or increases the frequency, rate or extent of skeletal muscle cell proliferation. RBO_relaxed.owl GO:0014859 biolink:NamedThing negative regulation of skeletal muscle cell proliferation Any process that stops, prevents, or reduces the frequency, rate or extent of skeletal muscle cell proliferation. RBO_relaxed.owl GO:0016202 biolink:NamedThing regulation of striated muscle tissue development Any process that modulates the frequency, rate or extent of striated muscle development. RBO_relaxed.owl GO:0016525 biolink:NamedThing negative regulation of angiogenesis Any process that stops, prevents, or reduces the frequency, rate or extent of angiogenesis. RBO_relaxed.owl GO:0017148 biolink:NamedThing negative regulation of translation Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA. RBO_relaxed.owl GO:0017157 biolink:NamedThing regulation of exocytosis Any process that modulates the frequency, rate or extent of exocytosis. RBO_relaxed.owl GO:0019216 biolink:NamedThing regulation of lipid metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipids. RBO_relaxed.owl GO:0019218 biolink:NamedThing regulation of steroid metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving steroids. RBO_relaxed.owl GO:0019219 biolink:NamedThing regulation of nucleobase-containing compound metabolic process Any cellular process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids. RBO_relaxed.owl GO:0019220 biolink:NamedThing regulation of phosphate metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving phosphates. RBO_relaxed.owl GO:0019222 biolink:NamedThing regulation of metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism. RBO_relaxed.owl GO:0022603 biolink:NamedThing regulation of anatomical structure morphogenesis Any process that modulates the frequency, rate or extent of anatomical structure morphogenesis. RBO_relaxed.owl GO:0022604 biolink:NamedThing regulation of cell morphogenesis Any process that modulates the frequency, rate or extent of cell morphogenesis. Cell morphogenesis is the developmental process in which the shape of a cell is generated and organized. RBO_relaxed.owl GO:0022898 biolink:NamedThing regulation of transmembrane transporter activity Any process that modulates the frequency, rate or extent of transmembrane transporter activity. RBO_relaxed.owl GO:0023051 biolink:NamedThing regulation of signaling Any process that modulates the frequency, rate or extent of a signaling process. RBO_relaxed.owl GO:0023056 biolink:NamedThing positive regulation of signaling Any process that activates, maintains or increases the frequency, rate or extent of a signaling process. RBO_relaxed.owl GO:0023057 biolink:NamedThing negative regulation of signaling Any process that stops, prevents, or reduces the frequency, rate or extent of a signaling process. RBO_relaxed.owl GO:0030278 biolink:NamedThing regulation of ossification Any process that modulates the frequency, rate or extent of ossification, the formation of bone or of a bony substance or the conversion of fibrous tissue or of cartilage into bone or a bony substance. RBO_relaxed.owl GO:0030279 biolink:NamedThing negative regulation of ossification Any process that stops, prevents, or reduces the frequency, rate or extent of ossification, the formation of bone or of a bony substance or the conversion of fibrous tissue or of cartilage into bone or a bony substance. RBO_relaxed.owl GO:0030307 biolink:NamedThing positive regulation of cell growth Any process that activates or increases the frequency, rate, extent or direction of cell growth. RBO_relaxed.owl GO:0030308 biolink:NamedThing negative regulation of cell growth Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth. RBO_relaxed.owl GO:0030334 biolink:NamedThing regulation of cell migration Any process that modulates the frequency, rate or extent of cell migration. RBO_relaxed.owl GO:0030335 biolink:NamedThing positive regulation of cell migration Any process that activates or increases the frequency, rate or extent of cell migration. RBO_relaxed.owl GO:0030336 biolink:NamedThing negative regulation of cell migration Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration. RBO_relaxed.owl GO:0030856 biolink:NamedThing regulation of epithelial cell differentiation Any process that modulates the frequency, rate or extent of epithelial cell differentiation. RBO_relaxed.owl GO:0030857 biolink:NamedThing negative regulation of epithelial cell differentiation Any process that stops, prevents, or reduces the frequency, rate or extent of epithelial cell differentiation. RBO_relaxed.owl GO:0030858 biolink:NamedThing positive regulation of epithelial cell differentiation Any process that activates or increases the frequency, rate or extent of epithelial cell differentiation. RBO_relaxed.owl GO:0031110 biolink:NamedThing regulation of microtubule polymerization or depolymerization Any process that modulates the frequency, rate or extent of microtubule polymerization or depolymerization by the addition or removal of tubulin heterodimers from a microtubule. RBO_relaxed.owl GO:0031111 biolink:NamedThing negative regulation of microtubule polymerization or depolymerization Any process that stops, prevents, or reduces the frequency, rate or extent of microtubule polymerization or depolymerization. RBO_relaxed.owl GO:0031112 biolink:NamedThing positive regulation of microtubule polymerization or depolymerization Any process that activates or increases the frequency, rate or extent of microtubule polymerization or depolymerization. RBO_relaxed.owl GO:0031113 biolink:NamedThing regulation of microtubule polymerization Any process that modulates the frequency, rate or extent of microtubule polymerization. RBO_relaxed.owl GO:0031114 biolink:NamedThing regulation of microtubule depolymerization Any process that modulates the frequency, rate or extent of microtubule depolymerization. RBO_relaxed.owl GO:0031115 biolink:NamedThing negative regulation of microtubule polymerization Any process that stops, prevents, or reduces the frequency, rate or extent of microtubule polymerization. RBO_relaxed.owl GO:0031116 biolink:NamedThing positive regulation of microtubule polymerization Any process that activates or increases the frequency, rate or extent of microtubule polymerization. RBO_relaxed.owl GO:0031117 biolink:NamedThing positive regulation of microtubule depolymerization Any process that activates or increases the frequency, rate or extent of microtubule depolymerization. RBO_relaxed.owl GO:0031323 biolink:NamedThing regulation of cellular metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances. RBO_relaxed.owl GO:0031324 biolink:NamedThing negative regulation of cellular metabolic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances. RBO_relaxed.owl GO:0031325 biolink:NamedThing positive regulation of cellular metabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances. RBO_relaxed.owl GO:0031326 biolink:NamedThing regulation of cellular biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells. RBO_relaxed.owl GO:0031327 biolink:NamedThing negative regulation of cellular biosynthetic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells. RBO_relaxed.owl GO:0031328 biolink:NamedThing positive regulation of cellular biosynthetic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells. RBO_relaxed.owl GO:0031329 biolink:NamedThing regulation of cellular catabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells. RBO_relaxed.owl GO:0031330 biolink:NamedThing negative regulation of cellular catabolic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells. RBO_relaxed.owl GO:0031331 biolink:NamedThing positive regulation of cellular catabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells. RBO_relaxed.owl GO:0031333 biolink:NamedThing negative regulation of protein-containing complex assembly Any process that stops, prevents, or reduces the frequency, rate or extent of protein complex assembly. RBO_relaxed.owl GO:0031334 biolink:NamedThing positive regulation of protein-containing complex assembly Any process that activates or increases the frequency, rate or extent of protein complex assembly. RBO_relaxed.owl GO:0031338 biolink:NamedThing regulation of vesicle fusion Any process that modulates the frequency, rate or extent of vesicle fusion. RBO_relaxed.owl GO:0031339 biolink:NamedThing negative regulation of vesicle fusion Any process that stops, prevents, or reduces the frequency, rate or extent of vesicle fusion. RBO_relaxed.owl GO:0031340 biolink:NamedThing positive regulation of vesicle fusion Any process that activates or increases the frequency, rate or extent of vesicle fusion. RBO_relaxed.owl GO:0031345 biolink:NamedThing negative regulation of cell projection organization Any process that stops, prevents, or reduces the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell projections. RBO_relaxed.owl GO:0031346 biolink:NamedThing positive regulation of cell projection organization Any process that activates or increases the frequency, rate or extent of the process involved in the formation, arrangement of constituent parts, or disassembly of cell projections. RBO_relaxed.owl GO:0031644 biolink:NamedThing regulation of nervous system process Any process that modulates the frequency, rate or extent of a neurophysiological process, an organ system process carried out by any of the organs or tissues of the nervous system. RBO_relaxed.owl GO:0031645 biolink:NamedThing negative regulation of nervous system process Any process that stops, prevents, or reduces the frequency, rate or extent of a neurophysiological process. RBO_relaxed.owl GO:0031646 biolink:NamedThing positive regulation of nervous system process Any process that activates or increases the frequency, rate or extent of a neurophysiological process. RBO_relaxed.owl GO:0032024 biolink:NamedThing positive regulation of insulin secretion Any process that activates or increases the frequency, rate or extent of the regulated release of insulin. RBO_relaxed.owl GO:0032057 biolink:NamedThing negative regulation of translational initiation in response to stress Any process that stops, prevents or reduces the rate of translation initiation as a result of a stimulus indicating the organism is under stress. RBO_relaxed.owl GO:0032058 biolink:NamedThing positive regulation of translational initiation in response to stress Any process that activates or increases the frequency, rate or extent of translation initiation as a result of a stimulus indicating the organism is under stress. RBO_relaxed.owl GO:0032069 biolink:NamedThing regulation of nuclease activity Any process that modulates the frequency, rate or extent of nuclease activity, the hydrolysis of ester linkages within nucleic acids. RBO_relaxed.owl GO:0032070 biolink:NamedThing regulation of deoxyribonuclease activity Any process that modulates the frequency, rate or extent of deoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid. RBO_relaxed.owl GO:0032074 biolink:NamedThing negative regulation of nuclease activity Any process that stops or reduces the rate of nuclease activity, the hydrolysis of ester linkages within nucleic acids. RBO_relaxed.owl GO:0032075 biolink:NamedThing positive regulation of nuclease activity Any process that activates or increases the frequency, rate or extent of nuclease activity, the hydrolysis of ester linkages within nucleic acids. RBO_relaxed.owl GO:0032076 biolink:NamedThing negative regulation of deoxyribonuclease activity Any process that stops or reduces the rate of deoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid. RBO_relaxed.owl GO:0032077 biolink:NamedThing positive regulation of deoxyribonuclease activity Any process that activates or increases the frequency, rate or extent of deoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid. RBO_relaxed.owl GO:0032101 biolink:NamedThing regulation of response to external stimulus Any process that modulates the frequency, rate or extent of a response to an external stimulus. RBO_relaxed.owl GO:0032102 biolink:NamedThing negative regulation of response to external stimulus Any process that stops, prevents, or reduces the frequency, rate or extent of a response to an external stimulus. RBO_relaxed.owl GO:0032103 biolink:NamedThing positive regulation of response to external stimulus Any process that activates, maintains or increases the rate of a response to an external stimulus. RBO_relaxed.owl GO:0032222 biolink:NamedThing regulation of synaptic transmission, cholinergic Any process that modulates the frequency, rate or extent of cholinergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter acetylcholine. RBO_relaxed.owl GO:0032223 biolink:NamedThing negative regulation of synaptic transmission, cholinergic Any process that stops, prevents, or reduces the frequency, rate or extent of cholinergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter acetylcholine. RBO_relaxed.owl GO:0032224 biolink:NamedThing positive regulation of synaptic transmission, cholinergic Any process that activates, maintains or increases the frequency, rate or extent of cholinergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter acetylcholine. RBO_relaxed.owl GO:0032231 biolink:NamedThing regulation of actin filament bundle assembly Any process that modulates the frequency, rate or extent of the assembly of actin filament bundles. RBO_relaxed.owl GO:0032232 biolink:NamedThing negative regulation of actin filament bundle assembly Any process that stops, prevents, or reduces the frequency, rate or extent of the assembly of actin filament bundles. RBO_relaxed.owl GO:0032233 biolink:NamedThing positive regulation of actin filament bundle assembly Any process that activates or increases the frequency, rate or extent of the assembly of actin filament bundles. RBO_relaxed.owl GO:0032239 biolink:NamedThing regulation of nucleobase-containing compound transport Any process that modulates the frequency, rate or extent of the directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. RBO_relaxed.owl GO:0032240 biolink:NamedThing negative regulation of nucleobase-containing compound transport Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. RBO_relaxed.owl GO:0032241 biolink:NamedThing positive regulation of nucleobase-containing compound transport Any process that activates or increases the frequency, rate or extent of the directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. RBO_relaxed.owl GO:0032271 biolink:NamedThing regulation of protein polymerization Any process that modulates the frequency, rate or extent of the process of creating protein polymers. RBO_relaxed.owl GO:0032272 biolink:NamedThing negative regulation of protein polymerization Any process that stops, prevents, or reduces the frequency, rate or extent of the process of creating protein polymers. RBO_relaxed.owl GO:0032273 biolink:NamedThing positive regulation of protein polymerization Any process that activates or increases the frequency, rate or extent of the process of creating protein polymers. RBO_relaxed.owl GO:0032330 biolink:NamedThing regulation of chondrocyte differentiation Any process that modulates the frequency, rate or extent of chondrocyte differentiation. RBO_relaxed.owl GO:0032331 biolink:NamedThing negative regulation of chondrocyte differentiation Any process that stops, prevents, or reduces the frequency, rate or extent of chondrocyte differentiation. RBO_relaxed.owl GO:0032332 biolink:NamedThing positive regulation of chondrocyte differentiation Any process that activates or increases the frequency, rate or extent of chondrocyte differentiation. RBO_relaxed.owl GO:0032368 biolink:NamedThing regulation of lipid transport Any process that modulates the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. RBO_relaxed.owl GO:0032369 biolink:NamedThing negative regulation of lipid transport Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. RBO_relaxed.owl GO:0032370 biolink:NamedThing positive regulation of lipid transport Any process that activates or increases the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. RBO_relaxed.owl GO:0032377 biolink:NamedThing regulation of intracellular lipid transport Any process that modulates the frequency, rate or extent of the directed movement of lipids within cells. RBO_relaxed.owl GO:0032378 biolink:NamedThing negative regulation of intracellular lipid transport Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of lipids within cells. RBO_relaxed.owl GO:0032379 biolink:NamedThing positive regulation of intracellular lipid transport Any process that activates or increases the frequency, rate or extent of the directed movement of lipids within cells. RBO_relaxed.owl GO:0032386 biolink:NamedThing regulation of intracellular transport Any process that modulates the frequency, rate or extent of the directed movement of substances within cells. RBO_relaxed.owl GO:0032387 biolink:NamedThing negative regulation of intracellular transport Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of substances within cells. RBO_relaxed.owl GO:0032388 biolink:NamedThing positive regulation of intracellular transport Any process that activates or increases the frequency, rate or extent of the directed movement of substances within cells. RBO_relaxed.owl GO:0032409 biolink:NamedThing regulation of transporter activity Any process that modulates the activity of a transporter. RBO_relaxed.owl GO:0032410 biolink:NamedThing negative regulation of transporter activity Any process that stops or reduces the activity of a transporter. RBO_relaxed.owl GO:0032411 biolink:NamedThing positive regulation of transporter activity Any process that activates or increases the activity of a transporter. RBO_relaxed.owl GO:0032412 biolink:NamedThing regulation of monoatomic ion transmembrane transporter activity Any process that modulates the activity of an ion transporter. RBO_relaxed.owl GO:0032413 biolink:NamedThing negative regulation of ion transmembrane transporter activity Any process that stops or reduces the activity of an ion transporter. RBO_relaxed.owl GO:0032414 biolink:NamedThing positive regulation of ion transmembrane transporter activity Any process that activates or increases the activity of an ion transporter. RBO_relaxed.owl GO:0032530 biolink:NamedThing regulation of microvillus organization Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a microvillus. RBO_relaxed.owl GO:0032534 biolink:NamedThing regulation of microvillus assembly A process that modulates the formation of a microvillus. RBO_relaxed.owl GO:0032871 biolink:NamedThing regulation of karyogamy Any process that modulates the frequency, rate or extent of karyogamy, the creation of a single nucleus from multiple nuclei as a result of membrane fusion. RBO_relaxed.owl GO:0032878 biolink:NamedThing regulation of establishment or maintenance of cell polarity Any process that modulates the frequency, rate or extent of the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns. RBO_relaxed.owl GO:0032879 biolink:NamedThing regulation of localization Any process that modulates the frequency, rate or extent of any process in which a cell, a substance, or a cellular entity is transported to, or maintained in, a specific location. RBO_relaxed.owl GO:0032880 biolink:NamedThing regulation of protein localization Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location. RBO_relaxed.owl GO:0032881 biolink:NamedThing regulation of polysaccharide metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving polysaccharides. RBO_relaxed.owl GO:0032885 biolink:NamedThing regulation of polysaccharide biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of polysaccharides. RBO_relaxed.owl GO:0032886 biolink:NamedThing regulation of microtubule-based process Any process that modulates the frequency, rate or extent of any cellular process that depends upon or alters the microtubule cytoskeleton. RBO_relaxed.owl GO:0032890 biolink:NamedThing regulation of organic acid transport Any process that modulates the frequency, rate or extent of the directed movement of organic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. RBO_relaxed.owl GO:0032891 biolink:NamedThing negative regulation of organic acid transport Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of organic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. RBO_relaxed.owl GO:0032892 biolink:NamedThing positive regulation of organic acid transport Any process that activates or increases the frequency, rate or extent of the directed movement of organic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. RBO_relaxed.owl GO:0032944 biolink:NamedThing regulation of mononuclear cell proliferation Any process that modulates the frequency, rate or extent of mononuclear cell proliferation. RBO_relaxed.owl GO:0032945 biolink:NamedThing negative regulation of mononuclear cell proliferation Any process that stops, prevents, or reduces the frequency, rate or extent of mononuclear cell proliferation. RBO_relaxed.owl GO:0032946 biolink:NamedThing positive regulation of mononuclear cell proliferation Any process that activates or increases the frequency, rate or extent of mononuclear cell proliferation. RBO_relaxed.owl GO:0032956 biolink:NamedThing regulation of actin cytoskeleton organization Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins. RBO_relaxed.owl GO:0032965 biolink:NamedThing regulation of collagen biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. RBO_relaxed.owl GO:0032966 biolink:NamedThing negative regulation of collagen biosynthetic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. RBO_relaxed.owl GO:0032967 biolink:NamedThing positive regulation of collagen biosynthetic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. RBO_relaxed.owl GO:0032970 biolink:NamedThing regulation of actin filament-based process Any process that modulates the frequency, rate or extent of any cellular process that depends upon or alters the actin cytoskeleton. RBO_relaxed.owl GO:0033032 biolink:NamedThing regulation of myeloid cell apoptotic process Any process that modulates the frequency, rate, or extent of myeloid cell apoptotic process. RBO_relaxed.owl GO:0033033 biolink:NamedThing negative regulation of myeloid cell apoptotic process Any process that stops, prevents, or reduces the frequency, rate, or extent of a myeloid cell apoptotic process. RBO_relaxed.owl GO:0033034 biolink:NamedThing positive regulation of myeloid cell apoptotic process Any process that activates or increases the frequency, rate, or extent of myeloid cell apoptotic process. RBO_relaxed.owl GO:0033044 biolink:NamedThing regulation of chromosome organization Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a chromosome. RBO_relaxed.owl GO:0033045 biolink:NamedThing regulation of sister chromatid segregation Any process that modulates the frequency, rate or extent of sister chromatid segregation. RBO_relaxed.owl GO:0033046 biolink:NamedThing negative regulation of sister chromatid segregation Any process that stops, prevents, or reduces the frequency, rate or extent of sister chromatid segregation. RBO_relaxed.owl GO:0033047 biolink:NamedThing regulation of mitotic sister chromatid segregation Any process that modulates the frequency, rate or extent of sister chromatid segregation during mitosis. RBO_relaxed.owl GO:0033048 biolink:NamedThing negative regulation of mitotic sister chromatid segregation Any process that stops, prevents, or reduces the frequency, rate or extent of sister chromatid segregation during mitosis. RBO_relaxed.owl GO:0033157 biolink:NamedThing regulation of intracellular protein transport Any process that modulates the frequency, rate or extent of the directed movement of proteins within cells. RBO_relaxed.owl GO:0033238 biolink:NamedThing regulation of amine metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform amines. RBO_relaxed.owl GO:0033239 biolink:NamedThing negative regulation of amine metabolic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving amines. RBO_relaxed.owl GO:0033240 biolink:NamedThing positive regulation of amine metabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving amines. RBO_relaxed.owl GO:0033241 biolink:NamedThing regulation of amine catabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways leading to the breakdown of amines. RBO_relaxed.owl GO:0033242 biolink:NamedThing negative regulation of amine catabolic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways leading to the breakdown of amines. RBO_relaxed.owl GO:0033243 biolink:NamedThing positive regulation of amine catabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways leading to the breakdown of amines. RBO_relaxed.owl GO:0033604 biolink:NamedThing negative regulation of catecholamine secretion Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a catecholamine. RBO_relaxed.owl GO:0033605 biolink:NamedThing positive regulation of catecholamine secretion Any process that activates or increases the frequency, rate or extent of the regulated release of a catecholamine. RBO_relaxed.owl GO:0033673 biolink:NamedThing negative regulation of kinase activity Any process that stops, prevents, or reduces the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. RBO_relaxed.owl GO:0033674 biolink:NamedThing positive regulation of kinase activity Any process that activates or increases the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. RBO_relaxed.owl GO:0034242 biolink:NamedThing negative regulation of syncytium formation by plasma membrane fusion Any process that decreases the frequency, rate or extent of the formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells. RBO_relaxed.owl GO:0034248 biolink:NamedThing regulation of amide metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving amides. RBO_relaxed.owl GO:0034249 biolink:NamedThing negative regulation of amide metabolic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving amides. RBO_relaxed.owl GO:0034250 biolink:NamedThing positive regulation of amide metabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving amides. RBO_relaxed.owl GO:0034251 biolink:NamedThing regulation of amide catabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of amides. RBO_relaxed.owl GO:0034252 biolink:NamedThing negative regulation of amide catabolic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of amides. RBO_relaxed.owl GO:0034253 biolink:NamedThing positive regulation of amide catabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of amides. RBO_relaxed.owl GO:0034350 biolink:NamedThing regulation of glial cell apoptotic process Any process that modulates the frequency, rate, or extent of glial cell apoptotic process. RBO_relaxed.owl GO:0034351 biolink:NamedThing negative regulation of glial cell apoptotic process Any process that stops, prevents, or reduces the frequency, rate, or extent of glial cell apoptotic process. RBO_relaxed.owl GO:0034352 biolink:NamedThing positive regulation of glial cell apoptotic process Any process that activates or increases the frequency, rate, or extent of glial cell apoptotic process. RBO_relaxed.owl GO:0034391 biolink:NamedThing regulation of smooth muscle cell apoptotic process Any process that modulates the frequency, rate, or extent of smooth muscle cell apoptotic process. RBO_relaxed.owl GO:0034392 biolink:NamedThing negative regulation of smooth muscle cell apoptotic process Any process that stops, prevents, or reduces the frequency, rate, or extent of smooth muscle cell apoptotic process. RBO_relaxed.owl GO:0034393 biolink:NamedThing positive regulation of smooth muscle cell apoptotic process Any process that activates or increases the frequency, rate, or extent of smooth muscle cell apoptotic process. RBO_relaxed.owl GO:0034762 biolink:NamedThing regulation of transmembrane transport Any process that modulates the frequency, rate or extent of the directed movement of a solute from one side of a membrane to the other. RBO_relaxed.owl GO:0034763 biolink:NamedThing negative regulation of transmembrane transport Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a solute from one side of a membrane to the other. RBO_relaxed.owl GO:0034764 biolink:NamedThing positive regulation of transmembrane transport Any process that activates or increases the frequency, rate or extent of the directed movement of a solute from one side of a membrane to the other. RBO_relaxed.owl GO:0034765 biolink:NamedThing regulation of monoatomic ion transmembrane transport Any process that modulates the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other. RBO_relaxed.owl GO:0034766 biolink:NamedThing negative regulation of monoatomic ion transmembrane transport Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other. RBO_relaxed.owl GO:0034767 biolink:NamedThing positive regulation of monoatomic ion transmembrane transport Any process that activates or increases the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other. RBO_relaxed.owl GO:0040012 biolink:NamedThing regulation of locomotion Any process that modulates the frequency, rate or extent of locomotion of a cell or organism. RBO_relaxed.owl GO:0040013 biolink:NamedThing negative regulation of locomotion Any process that stops, prevents, or reduces the frequency, rate or extent of locomotion of a cell or organism. RBO_relaxed.owl GO:0040014 biolink:NamedThing regulation of multicellular organism growth Any process that modulates the frequency, rate or extent of growth of the body of an organism so that it reaches its usual body size. RBO_relaxed.owl GO:0040015 biolink:NamedThing negative regulation of multicellular organism growth Any process that stops, prevents, or reduces the frequency, rate or extent of growth of an organism to reach its usual body size. RBO_relaxed.owl GO:0040017 biolink:NamedThing positive regulation of locomotion Any process that activates or increases the frequency, rate or extent of locomotion of a cell or organism. RBO_relaxed.owl GO:0040018 biolink:NamedThing positive regulation of multicellular organism growth Any process that activates or increases the frequency, rate or extent of growth of an organism to reach its usual body size. RBO_relaxed.owl GO:0040019 biolink:NamedThing positive regulation of embryonic development Any process that activates or increases the frequency, rate or extent of embryonic development. RBO_relaxed.owl GO:0040020 biolink:NamedThing regulation of meiotic nuclear division Any process that modulates the frequency, rate or extent of meiotic nuclear division, the process in which the nucleus of a diploid cell divides twice forming four haploid cells, one or more of which usually function as gametes. RBO_relaxed.owl GO:0042069 biolink:NamedThing regulation of catecholamine metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving catecholamines. RBO_relaxed.owl GO:0042127 biolink:NamedThing regulation of cell population proliferation Any process that modulates the frequency, rate or extent of cell proliferation. RBO_relaxed.owl GO:0042176 biolink:NamedThing regulation of protein catabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. RBO_relaxed.owl GO:0042177 biolink:NamedThing negative regulation of protein catabolic process Any process that stops, prevents or reduces the frequency, rate or extent of protein catabolic process. RBO_relaxed.owl GO:0042325 biolink:NamedThing regulation of phosphorylation Any process that modulates the frequency, rate or extent of addition of phosphate groups into a molecule. RBO_relaxed.owl GO:0042326 biolink:NamedThing negative regulation of phosphorylation Any process that stops, prevents or decreases the rate of addition of phosphate groups to a molecule. RBO_relaxed.owl GO:0042327 biolink:NamedThing positive regulation of phosphorylation Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to a molecule. RBO_relaxed.owl GO:0042478 biolink:NamedThing regulation of eye photoreceptor cell development Any process that modulates the frequency, rate or extent of eye photoreceptor development. RBO_relaxed.owl GO:0042479 biolink:NamedThing positive regulation of eye photoreceptor cell development Any process that activates or increases the frequency, rate or extent of eye photoreceptor development. RBO_relaxed.owl GO:0042480 biolink:NamedThing negative regulation of eye photoreceptor cell development Any process that stops, prevents, or reduces the frequency, rate or extent of eye photoreceptor development. RBO_relaxed.owl GO:0042762 biolink:NamedThing regulation of sulfur metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving sulfur, the nonmetallic element sulfur or compounds that contain sulfur. RBO_relaxed.owl GO:0042981 biolink:NamedThing regulation of apoptotic process Any process that modulates the occurrence or rate of cell death by apoptotic process. RBO_relaxed.owl GO:0042996 biolink:NamedThing regulation of Golgi to plasma membrane protein transport Any process that modulates the frequency, rate or extent of the transport of proteins from the Golgi to the plasma membrane. RBO_relaxed.owl GO:0042997 biolink:NamedThing negative regulation of Golgi to plasma membrane protein transport Any process that stops, prevents, or reduces the frequency, rate or extent of the transport of proteins from the Golgi to the plasma membrane. RBO_relaxed.owl GO:0042998 biolink:NamedThing positive regulation of Golgi to plasma membrane protein transport Any process that activates or increases the frequency, rate or extent of the transport of proteins from the Golgi to the plasma membrane. RBO_relaxed.owl GO:0043065 biolink:NamedThing positive regulation of apoptotic process Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process. RBO_relaxed.owl GO:0043066 biolink:NamedThing negative regulation of apoptotic process Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process. RBO_relaxed.owl GO:0043067 biolink:NamedThing regulation of programmed cell death Any process that modulates the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes. RBO_relaxed.owl GO:0043068 biolink:NamedThing positive regulation of programmed cell death Any process that activates or increases the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes. RBO_relaxed.owl GO:0043069 biolink:NamedThing negative regulation of programmed cell death Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes. RBO_relaxed.owl GO:0043085 biolink:NamedThing positive regulation of catalytic activity Any process that activates or increases the activity of an enzyme. RBO_relaxed.owl GO:0043086 biolink:NamedThing negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. RBO_relaxed.owl GO:0043134 biolink:NamedThing regulation of hindgut contraction Any process that modulates the frequency, rate or extent of muscle contraction of the hindgut, the posterior part of the alimentary canal, including the rectum, and the large intestine. RBO_relaxed.owl GO:0043242 biolink:NamedThing negative regulation of protein-containing complex disassembly Any process that stops, prevents, or reduces the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components. RBO_relaxed.owl GO:0043243 biolink:NamedThing positive regulation of protein-containing complex disassembly Any process that activates or increases the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components. RBO_relaxed.owl GO:0043255 biolink:NamedThing regulation of carbohydrate biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of carbohydrates. RBO_relaxed.owl GO:0043269 biolink:NamedThing regulation of monoatomic ion transport Any process that modulates the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. RBO_relaxed.owl GO:0043270 biolink:NamedThing positive regulation of monoatomic ion transport Any process that activates or increases the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. RBO_relaxed.owl GO:0043271 biolink:NamedThing negative regulation of monoatomic ion transport Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. RBO_relaxed.owl GO:0043455 biolink:NamedThing regulation of secondary metabolic process Any process that modulates the frequency, rate or extent of secondary metabolism, the chemical reactions and pathways involving compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon. RBO_relaxed.owl GO:0043467 biolink:NamedThing regulation of generation of precursor metabolites and energy Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and the processes involved in the liberation of energy from these substances. RBO_relaxed.owl GO:0043470 biolink:NamedThing regulation of carbohydrate catabolic process Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of carbohydrates. RBO_relaxed.owl GO:0043502 biolink:NamedThing regulation of muscle adaptation Any process that modulates the frequency, rate or extent of muscle adaptation. RBO_relaxed.owl GO:0043523 biolink:NamedThing regulation of neuron apoptotic process Any process that modulates the occurrence or rate of cell death by apoptotic process in neurons. RBO_relaxed.owl GO:0043524 biolink:NamedThing negative regulation of neuron apoptotic process Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons. RBO_relaxed.owl GO:0043525 biolink:NamedThing positive regulation of neuron apoptotic process Any process that activates or increases the frequency, rate or extent of cell death of neurons by apoptotic process. RBO_relaxed.owl GO:0043549 biolink:NamedThing regulation of kinase activity Any process that modulates the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. RBO_relaxed.owl GO:0043576 biolink:NamedThing regulation of respiratory gaseous exchange Any process that modulates the frequency, rate or extent of the process of gaseous exchange between an organism and its environment. RBO_relaxed.owl GO:0044057 biolink:NamedThing regulation of system process Any process that modulates the frequency, rate or extent of a system process, a multicellular organismal process carried out by any of the organs or tissues in an organ system. RBO_relaxed.owl GO:0044058 biolink:NamedThing regulation of digestive system process Any process that modulates the frequency, rate or extent of a digestive system process, a physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism. RBO_relaxed.owl GO:0044060 biolink:NamedThing regulation of endocrine process Any process that modulates the frequency, rate or extent of an endocrine process, a process involving the secretion of or response to endocrine hormones. An endocrine hormone is a hormone released into the circulatory system. RBO_relaxed.owl GO:0044062 biolink:NamedThing regulation of excretion Any process that modulates the frequency, rate, or extent of excretion, the elimination by an organism of the waste products that arise as a result of metabolic activity. RBO_relaxed.owl GO:0044065 biolink:NamedThing regulation of respiratory system process Any process that modulates the frequency, rate or extent of a respiratory system process, an organ system process carried out by any of the organs or tissues of the respiratory system. RBO_relaxed.owl GO:0044087 biolink:NamedThing regulation of cellular component biogenesis Any process that modulates the frequency, rate or extent of cellular component biogenesis, a process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component. RBO_relaxed.owl GO:0044088 biolink:NamedThing regulation of vacuole organization Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a vacuole. RBO_relaxed.owl GO:0044089 biolink:NamedThing positive regulation of cellular component biogenesis Any process that activates or increases the frequency, rate or extent of cellular component biogenesis, a process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component. RBO_relaxed.owl GO:0044090 biolink:NamedThing positive regulation of vacuole organization Any process that activates or increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a vacuole. RBO_relaxed.owl GO:0044092 biolink:NamedThing negative regulation of molecular function Any process that stops or reduces the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding. RBO_relaxed.owl GO:0044093 biolink:NamedThing positive regulation of molecular function Any process that activates or increases the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding. RBO_relaxed.owl GO:0045223 biolink:NamedThing regulation of CD4 production Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of CD4. RBO_relaxed.owl GO:0045224 biolink:NamedThing positive regulation of CD4 production Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of CD4. RBO_relaxed.owl GO:0045225 biolink:NamedThing negative regulation of CD4 production Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of CD4. RBO_relaxed.owl GO:0045595 biolink:NamedThing regulation of cell differentiation Any process that modulates the frequency, rate or extent of cell differentiation, the process in which relatively unspecialized cells acquire specialized structural and functional features. RBO_relaxed.owl GO:0045596 biolink:NamedThing negative regulation of cell differentiation Any process that stops, prevents, or reduces the frequency, rate or extent of cell differentiation. RBO_relaxed.owl GO:0045597 biolink:NamedThing positive regulation of cell differentiation Any process that activates or increases the frequency, rate or extent of cell differentiation. RBO_relaxed.owl GO:0045598 biolink:NamedThing regulation of fat cell differentiation Any process that modulates the frequency, rate or extent of adipocyte differentiation. RBO_relaxed.owl GO:0045599 biolink:NamedThing negative regulation of fat cell differentiation Any process that stops, prevents, or reduces the frequency, rate or extent of adipocyte differentiation. RBO_relaxed.owl GO:0045600 biolink:NamedThing positive regulation of fat cell differentiation Any process that activates or increases the frequency, rate or extent of adipocyte differentiation. RBO_relaxed.owl GO:0045601 biolink:NamedThing regulation of endothelial cell differentiation Any process that modulates the frequency, rate or extent of endothelial cell differentiation. RBO_relaxed.owl GO:0045602 biolink:NamedThing negative regulation of endothelial cell differentiation Any process that stops, prevents, or reduces the frequency, rate or extent of endothelial cell differentiation. RBO_relaxed.owl GO:0045603 biolink:NamedThing positive regulation of endothelial cell differentiation Any process that activates or increases the frequency, rate or extent of endothelial cell differentiation. RBO_relaxed.owl GO:0045604 biolink:NamedThing regulation of epidermal cell differentiation Any process that modulates the frequency, rate or extent of epidermal cell differentiation. RBO_relaxed.owl GO:0045605 biolink:NamedThing negative regulation of epidermal cell differentiation Any process that stops, prevents, or reduces the frequency, rate or extent of epidermal cell differentiation. RBO_relaxed.owl GO:0045606 biolink:NamedThing positive regulation of epidermal cell differentiation Any process that activates or increases the frequency, rate or extent of epidermal cell differentiation. RBO_relaxed.owl GO:0045637 biolink:NamedThing regulation of myeloid cell differentiation Any process that modulates the frequency, rate or extent of myeloid cell differentiation. RBO_relaxed.owl GO:0045638 biolink:NamedThing negative regulation of myeloid cell differentiation Any process that stops, prevents, or reduces the frequency, rate or extent of myeloid cell differentiation. RBO_relaxed.owl GO:0045639 biolink:NamedThing positive regulation of myeloid cell differentiation Any process that activates or increases the frequency, rate or extent of myeloid cell differentiation. RBO_relaxed.owl GO:0045646 biolink:NamedThing regulation of erythrocyte differentiation Any process that modulates the frequency, rate or extent of erythrocyte differentiation. RBO_relaxed.owl GO:0045647 biolink:NamedThing negative regulation of erythrocyte differentiation Any process that stops, prevents, or reduces the frequency, rate or extent of erythrocyte differentiation. RBO_relaxed.owl GO:0045648 biolink:NamedThing positive regulation of erythrocyte differentiation Any process that activates or increases the frequency, rate or extent of erythrocyte differentiation. RBO_relaxed.owl GO:0045652 biolink:NamedThing regulation of megakaryocyte differentiation Any process that modulates the frequency, rate or extent of megakaryocyte differentiation. RBO_relaxed.owl GO:0045653 biolink:NamedThing negative regulation of megakaryocyte differentiation Any process that stops, prevents, or reduces the frequency, rate or extent of megakaryocyte differentiation. RBO_relaxed.owl GO:0045654 biolink:NamedThing positive regulation of megakaryocyte differentiation Any process that activates or increases the frequency, rate or extent of megakaryocyte differentiation. RBO_relaxed.owl GO:0045661 biolink:NamedThing regulation of myoblast differentiation Any process that modulates the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. RBO_relaxed.owl GO:0045662 biolink:NamedThing negative regulation of myoblast differentiation Any process that stops, prevents, or reduces the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. RBO_relaxed.owl GO:0045663 biolink:NamedThing positive regulation of myoblast differentiation Any process that activates or increases the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. RBO_relaxed.owl GO:0045664 biolink:NamedThing regulation of neuron differentiation Any process that modulates the frequency, rate or extent of neuron differentiation. RBO_relaxed.owl GO:0045665 biolink:NamedThing negative regulation of neuron differentiation Any process that stops, prevents, or reduces the frequency, rate or extent of neuron differentiation. RBO_relaxed.owl GO:0045666 biolink:NamedThing positive regulation of neuron differentiation Any process that activates or increases the frequency, rate or extent of neuron differentiation. RBO_relaxed.owl GO:0045682 biolink:NamedThing regulation of epidermis development Any process that modulates the frequency, rate or extent of epidermis development. RBO_relaxed.owl GO:0045683 biolink:NamedThing negative regulation of epidermis development Any process that stops, prevents, or reduces the frequency, rate or extent of epidermis development. RBO_relaxed.owl GO:0045684 biolink:NamedThing positive regulation of epidermis development Any process that activates or increases the frequency, rate or extent of epidermis development. RBO_relaxed.owl GO:0045685 biolink:NamedThing regulation of glial cell differentiation Any process that modulates the frequency, rate or extent of glia cell differentiation. RBO_relaxed.owl GO:0045686 biolink:NamedThing negative regulation of glial cell differentiation Any process that stops, prevents, or reduces the frequency, rate or extent of glia cell differentiation. RBO_relaxed.owl GO:0045687 biolink:NamedThing positive regulation of glial cell differentiation Any process that activates or increases the frequency, rate or extent of glia cell differentiation. RBO_relaxed.owl GO:0045719 biolink:NamedThing negative regulation of glycogen biosynthetic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen. RBO_relaxed.owl GO:0045721 biolink:NamedThing negative regulation of gluconeogenesis Any process that stops, prevents, or reduces the frequency, rate or extent of gluconeogenesis. RBO_relaxed.owl GO:0045722 biolink:NamedThing positive regulation of gluconeogenesis Any process that activates or increases the frequency, rate or extent of gluconeogenesis. RBO_relaxed.owl GO:0045724 biolink:NamedThing positive regulation of cilium assembly Any process that activates or increases the frequency, rate or extent of the formation of a cilium. RBO_relaxed.owl GO:0045725 biolink:NamedThing positive regulation of glycogen biosynthetic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen. RBO_relaxed.owl GO:0045727 biolink:NamedThing positive regulation of translation Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA. RBO_relaxed.owl GO:0045732 biolink:NamedThing positive regulation of protein catabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. RBO_relaxed.owl GO:0045734 biolink:NamedThing regulation of acetate catabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of acetate, the anion of acetic acid. RBO_relaxed.owl GO:0045738 biolink:NamedThing negative regulation of DNA repair Any process that stops, prevents, or reduces the frequency, rate or extent of DNA repair. RBO_relaxed.owl GO:0045739 biolink:NamedThing positive regulation of DNA repair Any process that activates or increases the frequency, rate or extent of DNA repair. RBO_relaxed.owl GO:0045753 biolink:NamedThing negative regulation of acetate catabolic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of acetate. RBO_relaxed.owl GO:0045754 biolink:NamedThing positive regulation of acetate catabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of acetate. RBO_relaxed.owl GO:0045759 biolink:NamedThing negative regulation of action potential Any process that stops, prevents, or reduces the frequency, rate or extent of action potential creation, propagation or termination. This typically occurs via modulation of the activity or expression of voltage-gated ion channels. RBO_relaxed.owl GO:0045760 biolink:NamedThing positive regulation of action potential Any process that activates or increases the frequency, rate or extent of action potential creation, propagation or termination. This typically occurs via modulation of the activity or expression of voltage-gated ion channels. RBO_relaxed.owl GO:0045763 biolink:NamedThing negative regulation of cellular amino acid metabolic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving amino acid. RBO_relaxed.owl GO:0045764 biolink:NamedThing positive regulation of amino acid metabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving amino acid. RBO_relaxed.owl GO:0045765 biolink:NamedThing regulation of angiogenesis Any process that modulates the frequency, rate or extent of angiogenesis. RBO_relaxed.owl GO:0045766 biolink:NamedThing positive regulation of angiogenesis Any process that activates or increases angiogenesis. RBO_relaxed.owl GO:0045769 biolink:NamedThing negative regulation of asymmetric cell division Any process that stops, prevents, or reduces the frequency, rate or extent of asymmetric cell division. RBO_relaxed.owl GO:0045770 biolink:NamedThing positive regulation of asymmetric cell division Any process that activates or increases the frequency, rate or extent of asymmetric cell division. RBO_relaxed.owl GO:0045778 biolink:NamedThing positive regulation of ossification Any process that activates or increases the frequency, rate or extent of ossification, the formation of bone or of a bony substance or the conversion of fibrous tissue or of cartilage into bone or a bony substance. RBO_relaxed.owl GO:0045786 biolink:NamedThing negative regulation of cell cycle Any process that stops, prevents or reduces the rate or extent of progression through the cell cycle. RBO_relaxed.owl GO:0045787 biolink:NamedThing positive regulation of cell cycle Any process that activates or increases the rate or extent of progression through the cell cycle. RBO_relaxed.owl GO:0045818 biolink:NamedThing negative regulation of glycogen catabolic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glycogen. RBO_relaxed.owl GO:0045819 biolink:NamedThing positive regulation of glycogen catabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glycogen. RBO_relaxed.owl GO:0045822 biolink:NamedThing negative regulation of heart contraction Any process that stops, prevents, or reduces the frequency, rate or extent of heart contraction. RBO_relaxed.owl GO:0045823 biolink:NamedThing positive regulation of heart contraction Any process that activates or increases the frequency, rate or extent of heart contraction. RBO_relaxed.owl GO:0045833 biolink:NamedThing negative regulation of lipid metabolic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving lipids. RBO_relaxed.owl GO:0045834 biolink:NamedThing positive regulation of lipid metabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving lipids. RBO_relaxed.owl GO:0045835 biolink:NamedThing negative regulation of meiotic nuclear division Any process that stops, prevents, or reduces the frequency, rate or extent of meiosis. RBO_relaxed.owl GO:0045836 biolink:NamedThing positive regulation of meiotic nuclear division Any process that activates or increases the frequency, rate or extent of meiosis. RBO_relaxed.owl GO:0045839 biolink:NamedThing negative regulation of mitotic nuclear division Any process that stops, prevents or reduces the rate or extent of mitosis. Mitosis is the division of the eukaryotic cell nucleus to produce two daughter nuclei that, usually, contain the identical chromosome complement to their mother. RBO_relaxed.owl GO:0045840 biolink:NamedThing positive regulation of mitotic nuclear division Any process that activates or increases the frequency, rate or extent of mitosis. RBO_relaxed.owl GO:0045843 biolink:NamedThing negative regulation of striated muscle tissue development Any process that stops, prevents, or reduces the frequency, rate or extent of striated muscle development. RBO_relaxed.owl GO:0045844 biolink:NamedThing positive regulation of striated muscle tissue development Any process that activates or increases the frequency, rate or extent of striated muscle development. RBO_relaxed.owl GO:0045900 biolink:NamedThing negative regulation of translational elongation Any process that stops, prevents, or reduces the frequency, rate or extent of translational elongation. RBO_relaxed.owl GO:0045901 biolink:NamedThing positive regulation of translational elongation Any process that activates or increases the frequency, rate or extent of translational elongation. RBO_relaxed.owl GO:0045904 biolink:NamedThing negative regulation of translational termination Any process that stops, prevents, or reduces the frequency, rate or extent of translational termination. RBO_relaxed.owl GO:0045905 biolink:NamedThing positive regulation of translational termination Any process that activates or increases the frequency, rate or extent of translational termination. RBO_relaxed.owl GO:0045912 biolink:NamedThing negative regulation of carbohydrate metabolic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving carbohydrate. RBO_relaxed.owl GO:0045913 biolink:NamedThing positive regulation of carbohydrate metabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving carbohydrate. RBO_relaxed.owl GO:0045914 biolink:NamedThing negative regulation of catecholamine metabolic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving catecholamine. RBO_relaxed.owl GO:0045915 biolink:NamedThing positive regulation of catecholamine metabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving catecholamine. RBO_relaxed.owl GO:0045920 biolink:NamedThing negative regulation of exocytosis Any process that stops, prevents, or reduces the frequency, rate or extent of exocytosis. RBO_relaxed.owl GO:0045921 biolink:NamedThing positive regulation of exocytosis Any process that activates or increases the frequency, rate or extent of exocytosis. RBO_relaxed.owl GO:0045930 biolink:NamedThing negative regulation of mitotic cell cycle Any process that stops, prevents or reduces the rate or extent of progression through the mitotic cell cycle. RBO_relaxed.owl GO:0045931 biolink:NamedThing positive regulation of mitotic cell cycle Any process that activates or increases the rate or extent of progression through the mitotic cell cycle. RBO_relaxed.owl GO:0045932 biolink:NamedThing negative regulation of muscle contraction Any process that stops, prevents, or reduces the frequency, rate or extent of muscle contraction. RBO_relaxed.owl GO:0045933 biolink:NamedThing positive regulation of muscle contraction Any process that activates or increases the frequency, rate or extent of muscle contraction. RBO_relaxed.owl GO:0045934 biolink:NamedThing negative regulation of nucleobase-containing compound metabolic process Any cellular process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids. RBO_relaxed.owl GO:0045935 biolink:NamedThing positive regulation of nucleobase-containing compound metabolic process Any cellular process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids. RBO_relaxed.owl GO:0045936 biolink:NamedThing negative regulation of phosphate metabolic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving phosphates. RBO_relaxed.owl GO:0045937 biolink:NamedThing positive regulation of phosphate metabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving phosphates. RBO_relaxed.owl GO:0045939 biolink:NamedThing negative regulation of steroid metabolic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving steroids. RBO_relaxed.owl GO:0045940 biolink:NamedThing positive regulation of steroid metabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving steroids. RBO_relaxed.owl GO:0045947 biolink:NamedThing negative regulation of translational initiation Any process that stops, prevents, or reduces the frequency, rate or extent of translational initiation. RBO_relaxed.owl GO:0045948 biolink:NamedThing positive regulation of translational initiation Any process that activates or increases the frequency, rate or extent of translational initiation. RBO_relaxed.owl GO:0045986 biolink:NamedThing negative regulation of smooth muscle contraction Any process that stops, prevents, or reduces the frequency, rate or extent of smooth muscle contraction. RBO_relaxed.owl GO:0045987 biolink:NamedThing positive regulation of smooth muscle contraction Any process that activates or increases the frequency, rate or extent of smooth muscle contraction. RBO_relaxed.owl GO:0045988 biolink:NamedThing negative regulation of striated muscle contraction Any process that stops, prevents, or reduces the frequency, rate or extent of striated muscle contraction. RBO_relaxed.owl GO:0045989 biolink:NamedThing positive regulation of striated muscle contraction Any process that activates or increases the frequency, rate or extent of striated muscle contraction. RBO_relaxed.owl GO:0045992 biolink:NamedThing negative regulation of embryonic development Any process that stops, prevents, or reduces the frequency, rate or extent of embryonic development. RBO_relaxed.owl GO:0045995 biolink:NamedThing regulation of embryonic development Any process that modulates the frequency, rate or extent of embryonic development. RBO_relaxed.owl GO:0046532 biolink:NamedThing regulation of photoreceptor cell differentiation Any process that modulates the frequency, rate or extent of photoreceptor cell differentiation. An example of this process is found in Drosophila melanogaster. RBO_relaxed.owl GO:0046533 biolink:NamedThing negative regulation of photoreceptor cell differentiation Any process that stops, prevents, or reduces the frequency, rate or extent of photoreceptor cell differentiation. An example of this process is found in Drosophila melanogaster. RBO_relaxed.owl GO:0046534 biolink:NamedThing positive regulation of photoreceptor cell differentiation Any process that activates or increases the frequency, rate or extent of photoreceptor cell differentiation. An example of this process is found in Drosophila melanogaster. RBO_relaxed.owl GO:0046620 biolink:NamedThing regulation of organ growth Any process that modulates the frequency, rate or extent of growth of an organ of an organism. RBO_relaxed.owl GO:0046621 biolink:NamedThing negative regulation of organ growth Any process that stops, prevents, or reduces the frequency, rate or extent of growth of an organ of an organism. RBO_relaxed.owl GO:0046622 biolink:NamedThing positive regulation of organ growth Any process that activates or increases the frequency, rate or extent of growth of an organ of an organism. RBO_relaxed.owl GO:0046668 biolink:NamedThing regulation of retinal cell programmed cell death Any process that modulates the frequency, rate or extent of programmed cell death that occurs in the retina. RBO_relaxed.owl GO:0046669 biolink:NamedThing regulation of compound eye retinal cell programmed cell death Any process that modulates the frequency, rate or extent of programmed cell death that occurs in the compound eye retina. RBO_relaxed.owl GO:0046670 biolink:NamedThing positive regulation of retinal cell programmed cell death Any process that activates or increases the frequency, rate or extent of programmed cell death that occurs in the retina. RBO_relaxed.owl GO:0046671 biolink:NamedThing negative regulation of retinal cell programmed cell death Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death that occurs in the retina. RBO_relaxed.owl GO:0046672 biolink:NamedThing positive regulation of compound eye retinal cell programmed cell death Any process that activates or increases the frequency, rate or extent of programmed cell death that occurs in the compound eye retina. RBO_relaxed.owl GO:0046673 biolink:NamedThing negative regulation of compound eye retinal cell programmed cell death Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death that occurs in the compound eye retina. RBO_relaxed.owl GO:0046676 biolink:NamedThing negative regulation of insulin secretion Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of insulin. RBO_relaxed.owl GO:0046883 biolink:NamedThing regulation of hormone secretion Any process that modulates the frequency, rate or extent of the regulated release of a hormone from a cell. RBO_relaxed.owl GO:0046887 biolink:NamedThing positive regulation of hormone secretion Any process that activates or increases the frequency, rate or extent of the regulated release of a hormone from a cell. RBO_relaxed.owl GO:0046888 biolink:NamedThing negative regulation of hormone secretion Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a hormone from a cell. RBO_relaxed.owl GO:0046889 biolink:NamedThing positive regulation of lipid biosynthetic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids. RBO_relaxed.owl GO:0046890 biolink:NamedThing regulation of lipid biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids. RBO_relaxed.owl GO:0046928 biolink:NamedThing regulation of neurotransmitter secretion Any process that modulates the frequency, rate or extent of the regulated release of a neurotransmitter from a cell. RBO_relaxed.owl GO:0046929 biolink:NamedThing negative regulation of neurotransmitter secretion Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a neurotransmitter. RBO_relaxed.owl GO:0048070 biolink:NamedThing regulation of developmental pigmentation Any process that modulates the frequency, rate or extent of the developmental process that results in the deposition of coloring matter in an organism. RBO_relaxed.owl GO:0048086 biolink:NamedThing negative regulation of developmental pigmentation Any process that decreases the frequency, rate or extent of the developmental process that results in the deposition of coloring matter in an organism. RBO_relaxed.owl GO:0048087 biolink:NamedThing positive regulation of developmental pigmentation Any process that increases the frequency, rate or extent of the developmental process that results in the deposition of coloring matter in an organism. RBO_relaxed.owl GO:0048145 biolink:NamedThing regulation of fibroblast proliferation Any process that modulates the frequency, rate or extent of multiplication or reproduction of fibroblast cells. RBO_relaxed.owl GO:0048146 biolink:NamedThing positive regulation of fibroblast proliferation Any process that activates or increases the frequency, rate or extent of multiplication or reproduction of fibroblast cells. RBO_relaxed.owl GO:0048147 biolink:NamedThing negative regulation of fibroblast proliferation Any process that stops, prevents, or reduces the frequency, rate or extent of multiplication or reproduction of fibroblast cells. RBO_relaxed.owl GO:0048209 biolink:NamedThing regulation of vesicle targeting, to, from or within Golgi Any process that modulates the frequency, rate, or destination of vesicle-mediated transport to, from or within the Golgi apparatus. RBO_relaxed.owl GO:0048518 biolink:NamedThing positive regulation of biological process Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule. RBO_relaxed.owl GO:0048519 biolink:NamedThing negative regulation of biological process Any process that stops, prevents, or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule. RBO_relaxed.owl GO:0048520 biolink:NamedThing positive regulation of behavior Any process that activates or increases the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli. RBO_relaxed.owl GO:0048521 biolink:NamedThing negative regulation of behavior Any process that stops, prevents, or reduces the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli. RBO_relaxed.owl GO:0048522 biolink:NamedThing positive regulation of cellular process Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. RBO_relaxed.owl GO:0048523 biolink:NamedThing negative regulation of cellular process Any process that stops, prevents, or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. RBO_relaxed.owl GO:0048580 biolink:NamedThing regulation of post-embryonic development Any process that modulates the frequency, rate or extent of post-embryonic development. Post-embryonic development is defined as the process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. RBO_relaxed.owl GO:0048581 biolink:NamedThing negative regulation of post-embryonic development Any process that stops, prevents, or reduces the frequency, rate or extent of post-embryonic development. Post-embryonic development is defined as the process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. RBO_relaxed.owl GO:0048582 biolink:NamedThing positive regulation of post-embryonic development Any process that activates or increases the frequency, rate or extent of post-embryonic development. Post-embryonic development is defined as the process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. RBO_relaxed.owl GO:0048583 biolink:NamedThing regulation of response to stimulus Any process that modulates the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. RBO_relaxed.owl GO:0048584 biolink:NamedThing positive regulation of response to stimulus Any process that activates, maintains or increases the rate of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. RBO_relaxed.owl GO:0048585 biolink:NamedThing negative regulation of response to stimulus Any process that stops, prevents, or reduces the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. RBO_relaxed.owl GO:0048631 biolink:NamedThing regulation of skeletal muscle tissue growth Any process that modulates the frequency, rate or extent of skeletal muscle growth. RBO_relaxed.owl GO:0048632 biolink:NamedThing negative regulation of skeletal muscle tissue growth Any process that stops, prevents, or reduces the frequency, rate or extent of skeletal muscle growth. RBO_relaxed.owl GO:0048633 biolink:NamedThing positive regulation of skeletal muscle tissue growth Any process that activates, maintains or increases the rate of skeletal muscle growth. RBO_relaxed.owl GO:0048634 biolink:NamedThing regulation of muscle organ development Any process that modulates the frequency, rate or extent of muscle development. RBO_relaxed.owl GO:0048635 biolink:NamedThing negative regulation of muscle organ development Any process that stops, prevents, or reduces the frequency, rate or extent of muscle development. RBO_relaxed.owl GO:0048636 biolink:NamedThing positive regulation of muscle organ development Any process that activates, maintains or increases the rate of muscle development. RBO_relaxed.owl GO:0048639 biolink:NamedThing positive regulation of developmental growth Any process that activates, maintains or increases the rate of developmental growth. RBO_relaxed.owl GO:0048640 biolink:NamedThing negative regulation of developmental growth Any process that stops, prevents, or reduces the frequency, rate or extent of developmental growth. RBO_relaxed.owl GO:0048641 biolink:NamedThing regulation of skeletal muscle tissue development Any process that modulates the frequency, rate or extent of skeletal muscle tissue development. RBO_relaxed.owl GO:0048642 biolink:NamedThing negative regulation of skeletal muscle tissue development Any process that stops, prevents, or reduces the frequency, rate or extent of skeletal muscle tissue development. RBO_relaxed.owl GO:0048643 biolink:NamedThing positive regulation of skeletal muscle tissue development Any process that activates, maintains or increases the rate of skeletal muscle tissue development. RBO_relaxed.owl GO:0048660 biolink:NamedThing regulation of smooth muscle cell proliferation Any process that modulates the frequency, rate or extent of smooth muscle cell proliferation. RBO_relaxed.owl GO:0048661 biolink:NamedThing positive regulation of smooth muscle cell proliferation Any process that activates or increases the rate or extent of smooth muscle cell proliferation. RBO_relaxed.owl GO:0048662 biolink:NamedThing negative regulation of smooth muscle cell proliferation Any process that stops, prevents or reduces the rate or extent of smooth muscle cell proliferation. RBO_relaxed.owl GO:0048742 biolink:NamedThing regulation of skeletal muscle fiber development Any process that modulates the frequency, rate or extent of skeletal muscle fiber development. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast. RBO_relaxed.owl GO:0048743 biolink:NamedThing positive regulation of skeletal muscle fiber development Any process that activates, maintains or increases the rate of skeletal muscle fiber development. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast. RBO_relaxed.owl GO:0048744 biolink:NamedThing negative regulation of skeletal muscle fiber development Any process that stops, prevents, or reduces the frequency, rate or extent of skeletal muscle fiber development. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast. RBO_relaxed.owl GO:0050433 biolink:NamedThing regulation of catecholamine secretion Any process that modulates the frequency, rate or extent of the regulated release of catecholamines. RBO_relaxed.owl GO:0050678 biolink:NamedThing regulation of epithelial cell proliferation Any process that modulates the frequency, rate or extent of epithelial cell proliferation. RBO_relaxed.owl GO:0050679 biolink:NamedThing positive regulation of epithelial cell proliferation Any process that activates or increases the rate or extent of epithelial cell proliferation. RBO_relaxed.owl GO:0050680 biolink:NamedThing negative regulation of epithelial cell proliferation Any process that stops, prevents or reduces the rate or extent of epithelial cell proliferation. RBO_relaxed.owl GO:0050708 biolink:NamedThing regulation of protein secretion Any process that modulates the frequency, rate or extent of the controlled release of a protein from a cell. RBO_relaxed.owl GO:0050709 biolink:NamedThing negative regulation of protein secretion Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of a protein from a cell. RBO_relaxed.owl GO:0050714 biolink:NamedThing positive regulation of protein secretion Any process that activates or increases the frequency, rate or extent of the controlled release of a protein from a cell. RBO_relaxed.owl GO:0050767 biolink:NamedThing regulation of neurogenesis Any process that modulates the frequency, rate or extent of neurogenesis, the generation of cells in the nervous system. RBO_relaxed.owl GO:0050768 biolink:NamedThing negative regulation of neurogenesis Any process that stops, prevents, or reduces the frequency, rate or extent of neurogenesis, the generation of cells within the nervous system. RBO_relaxed.owl GO:0050769 biolink:NamedThing positive regulation of neurogenesis Any process that activates or increases the frequency, rate or extent of neurogenesis, the generation of cells within the nervous system. RBO_relaxed.owl GO:0050776 biolink:NamedThing regulation of immune response Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus. RBO_relaxed.owl GO:0050777 biolink:NamedThing negative regulation of immune response Any process that stops, prevents, or reduces the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus. RBO_relaxed.owl GO:0050778 biolink:NamedThing positive regulation of immune response Any process that activates or increases the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus. RBO_relaxed.owl GO:0050789 biolink:NamedThing regulation of biological process Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule. RBO_relaxed.owl GO:0050790 biolink:NamedThing regulation of catalytic activity Any process that modulates the activity of an enzyme. RBO_relaxed.owl GO:0050793 biolink:NamedThing regulation of developmental process Any process that modulates the frequency, rate or extent of development, the biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). RBO_relaxed.owl GO:0050794 biolink:NamedThing regulation of cellular process Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. RBO_relaxed.owl GO:0050795 biolink:NamedThing regulation of behavior Any process that modulates the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli. RBO_relaxed.owl GO:0050796 biolink:NamedThing regulation of insulin secretion Any process that modulates the frequency, rate or extent of the regulated release of insulin. RBO_relaxed.owl GO:0050804 biolink:NamedThing modulation of chemical synaptic transmission Any process that modulates the frequency or amplitude of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. Amplitude, in this case, refers to the change in postsynaptic membrane potential due to a single instance of synaptic transmission. RBO_relaxed.owl GO:0050805 biolink:NamedThing negative regulation of synaptic transmission Any process that stops, prevents, or reduces the frequency, rate or extent of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. RBO_relaxed.owl GO:0050806 biolink:NamedThing positive regulation of synaptic transmission Any process that activates or increases the frequency, rate or extent of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. RBO_relaxed.owl GO:0050810 biolink:NamedThing regulation of steroid biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus. RBO_relaxed.owl GO:0050932 biolink:NamedThing regulation of pigment cell differentiation Any process that modulates the frequency, rate or extent of pigmented cell differentiation. RBO_relaxed.owl GO:0050941 biolink:NamedThing negative regulation of pigment cell differentiation Any process that stops, prevents, or reduces the frequency, rate or extent of pigment cell differentiation. RBO_relaxed.owl GO:0050942 biolink:NamedThing positive regulation of pigment cell differentiation Any process that activates or increases the frequency, rate or extent of pigment cell differentiation. RBO_relaxed.owl GO:0050994 biolink:NamedThing regulation of lipid catabolic process Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of lipids. RBO_relaxed.owl GO:0050995 biolink:NamedThing negative regulation of lipid catabolic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of lipids. RBO_relaxed.owl GO:0050996 biolink:NamedThing positive regulation of lipid catabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of lipids. RBO_relaxed.owl GO:0051046 biolink:NamedThing regulation of secretion Any process that modulates the frequency, rate or extent of the controlled release of a substance from a cell or a tissue. RBO_relaxed.owl GO:0051047 biolink:NamedThing positive regulation of secretion Any process that activates or increases the frequency, rate or extent of the controlled release of a substance from a cell or a tissue. RBO_relaxed.owl GO:0051048 biolink:NamedThing negative regulation of secretion Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of a substance from a cell or a tissue. RBO_relaxed.owl GO:0051049 biolink:NamedThing regulation of transport Any process that modulates the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. RBO_relaxed.owl GO:0051050 biolink:NamedThing positive regulation of transport Any process that activates or increases the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. RBO_relaxed.owl GO:0051051 biolink:NamedThing negative regulation of transport Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. RBO_relaxed.owl GO:0051052 biolink:NamedThing regulation of DNA metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving DNA. RBO_relaxed.owl GO:0051053 biolink:NamedThing negative regulation of DNA metabolic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving DNA. RBO_relaxed.owl GO:0051054 biolink:NamedThing positive regulation of DNA metabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving DNA. RBO_relaxed.owl GO:0051055 biolink:NamedThing negative regulation of lipid biosynthetic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids. RBO_relaxed.owl GO:0051093 biolink:NamedThing negative regulation of developmental process Any process that stops, prevents or reduces the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). RBO_relaxed.owl GO:0051094 biolink:NamedThing positive regulation of developmental process Any process that activates or increases the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). RBO_relaxed.owl GO:0051147 biolink:NamedThing regulation of muscle cell differentiation Any process that modulates the frequency, rate or extent of muscle cell differentiation. RBO_relaxed.owl GO:0051148 biolink:NamedThing negative regulation of muscle cell differentiation Any process that stops, prevents, or reduces the frequency, rate or extent of muscle cell differentiation. RBO_relaxed.owl GO:0051149 biolink:NamedThing positive regulation of muscle cell differentiation Any process that activates or increases the frequency, rate or extent of muscle cell differentiation. RBO_relaxed.owl GO:0051150 biolink:NamedThing regulation of smooth muscle cell differentiation Any process that modulates the frequency, rate or extent of smooth muscle cell differentiation. RBO_relaxed.owl GO:0051151 biolink:NamedThing negative regulation of smooth muscle cell differentiation Any process that stops, prevents, or reduces the frequency, rate or extent of smooth muscle cell differentiation. RBO_relaxed.owl GO:0051152 biolink:NamedThing positive regulation of smooth muscle cell differentiation Any process that activates or increases the frequency, rate or extent of smooth muscle cell differentiation. RBO_relaxed.owl GO:0051153 biolink:NamedThing regulation of striated muscle cell differentiation Any process that modulates the frequency, rate or extent of striated muscle cell differentiation. RBO_relaxed.owl GO:0051154 biolink:NamedThing negative regulation of striated muscle cell differentiation Any process that stops, prevents, or reduces the frequency, rate or extent of striated muscle cell differentiation. RBO_relaxed.owl GO:0051155 biolink:NamedThing positive regulation of striated muscle cell differentiation Any process that activates or increases the frequency, rate or extent of striated muscle cell differentiation. RBO_relaxed.owl GO:0051171 biolink:NamedThing regulation of nitrogen compound metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nitrogen or nitrogenous compounds. RBO_relaxed.owl GO:0051172 biolink:NamedThing negative regulation of nitrogen compound metabolic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nitrogen or nitrogenous compounds. RBO_relaxed.owl GO:0051173 biolink:NamedThing positive regulation of nitrogen compound metabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nitrogen or nitrogenous compounds. RBO_relaxed.owl GO:0051174 biolink:NamedThing regulation of phosphorus metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus. RBO_relaxed.owl GO:0051175 biolink:NamedThing negative regulation of sulfur metabolic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving sulfur or compounds containing sulfur. RBO_relaxed.owl GO:0051176 biolink:NamedThing positive regulation of sulfur metabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving sulfur or compounds containing sulfur. RBO_relaxed.owl GO:0051222 biolink:NamedThing positive regulation of protein transport Any process that activates or increases the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. RBO_relaxed.owl GO:0051223 biolink:NamedThing regulation of protein transport Any process that modulates the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. RBO_relaxed.owl GO:0051224 biolink:NamedThing negative regulation of protein transport Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. RBO_relaxed.owl GO:0051239 biolink:NamedThing regulation of multicellular organismal process Any process that modulates the frequency, rate or extent of a multicellular organismal process, the processes pertinent to the function of a multicellular organism above the cellular level; includes the integrated processes of tissues and organs. RBO_relaxed.owl GO:0051240 biolink:NamedThing positive regulation of multicellular organismal process Any process that activates or increases the frequency, rate or extent of an organismal process, any of the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs. RBO_relaxed.owl GO:0051241 biolink:NamedThing negative regulation of multicellular organismal process Any process that stops, prevents, or reduces the frequency, rate or extent of an organismal process, the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs. RBO_relaxed.owl GO:0051246 biolink:NamedThing regulation of protein metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein. RBO_relaxed.owl GO:0051247 biolink:NamedThing positive regulation of protein metabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein. RBO_relaxed.owl GO:0051248 biolink:NamedThing negative regulation of protein metabolic process Any process that stops, prevents, or reduces the frequency, rate or extent of chemical reactions and pathways involving a protein. RBO_relaxed.owl GO:0051252 biolink:NamedThing regulation of RNA metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving RNA. RBO_relaxed.owl GO:0051253 biolink:NamedThing negative regulation of RNA metabolic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving RNA. RBO_relaxed.owl GO:0051254 biolink:NamedThing positive regulation of RNA metabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving RNA. RBO_relaxed.owl GO:0051302 biolink:NamedThing regulation of cell division Any process that modulates the frequency, rate or extent of the physical partitioning and separation of a cell into daughter cells. RBO_relaxed.owl GO:0051336 biolink:NamedThing regulation of hydrolase activity Any process that modulates the frequency, rate or extent of hydrolase activity, the catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. RBO_relaxed.owl GO:0051338 biolink:NamedThing regulation of transferase activity Any process that modulates the frequency, rate or extent of transferase activity, the catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. RBO_relaxed.owl GO:0051345 biolink:NamedThing positive regulation of hydrolase activity Any process that activates or increases the frequency, rate or extent of hydrolase activity, the catalysis of the hydrolysis of various bonds. RBO_relaxed.owl GO:0051346 biolink:NamedThing negative regulation of hydrolase activity Any process that stops or reduces the rate of hydrolase activity, the catalysis of the hydrolysis of various bonds. RBO_relaxed.owl GO:0051347 biolink:NamedThing positive regulation of transferase activity Any process that activates or increases the frequency, rate or extent of transferase activity, the catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from a donor compound to an acceptor. RBO_relaxed.owl GO:0051348 biolink:NamedThing negative regulation of transferase activity Any process that stops or reduces the rate of transferase activity, the catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from a donor compound to an acceptor. RBO_relaxed.owl GO:0051445 biolink:NamedThing regulation of meiotic cell cycle Any process that modulates the rate or extent of progression through the meiotic cell cycle. RBO_relaxed.owl GO:0051446 biolink:NamedThing positive regulation of meiotic cell cycle Any process that activates or increases the frequency, rate or extent of progression through the meiotic cell cycle. RBO_relaxed.owl GO:0051447 biolink:NamedThing negative regulation of meiotic cell cycle Any process that stops, prevents or reduces the rate or extent of progression through the meiotic cell cycle. RBO_relaxed.owl GO:0051493 biolink:NamedThing regulation of cytoskeleton organization Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures. RBO_relaxed.owl GO:0051494 biolink:NamedThing negative regulation of cytoskeleton organization Any process that stops, prevents, or reduces the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures. RBO_relaxed.owl GO:0051495 biolink:NamedThing positive regulation of cytoskeleton organization Any process that activates or increases the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures. RBO_relaxed.owl GO:0051588 biolink:NamedThing regulation of neurotransmitter transport Any process that modulates the frequency, rate or extent of the directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. RBO_relaxed.owl GO:0051589 biolink:NamedThing negative regulation of neurotransmitter transport Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. RBO_relaxed.owl GO:0051590 biolink:NamedThing positive regulation of neurotransmitter transport Any process that activates or increases the frequency, rate or extent of the directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. RBO_relaxed.owl GO:0051621 biolink:NamedThing regulation of norepinephrine uptake Any process that modulates the frequency, rate or extent of the directed movement of the neurotransmitter norepinephrine into a cell. RBO_relaxed.owl GO:0051622 biolink:NamedThing negative regulation of norepinephrine uptake Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of norepinephrine into a cell. RBO_relaxed.owl GO:0051623 biolink:NamedThing positive regulation of norepinephrine uptake Any process that activates or increases the frequency, rate or extent of the directed movement of norepinephrine into a cell. RBO_relaxed.owl GO:0051631 biolink:NamedThing regulation of acetylcholine uptake Any process that modulates the frequency, rate or extent of the directed movement of the neurotransmitter acetylcholine into a cell. RBO_relaxed.owl GO:0051632 biolink:NamedThing negative regulation of acetylcholine uptake Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of acetylcholine into a cell. RBO_relaxed.owl GO:0051633 biolink:NamedThing positive regulation of acetylcholine uptake Any process that activates or increases the frequency, rate or extent of the directed movement of acetylcholine into a cell. RBO_relaxed.owl GO:0051726 biolink:NamedThing regulation of cell cycle Any process that modulates the rate or extent of progression through the cell cycle. RBO_relaxed.owl GO:0051781 biolink:NamedThing positive regulation of cell division Any process that activates or increases the frequency, rate or extent of cell division. RBO_relaxed.owl GO:0051782 biolink:NamedThing negative regulation of cell division Any process that stops, prevents, or reduces the frequency, rate or extent of cell division. RBO_relaxed.owl GO:0051783 biolink:NamedThing regulation of nuclear division Any process that modulates the frequency, rate or extent of nuclear division, the partitioning of the nucleus and its genetic information. RBO_relaxed.owl GO:0051784 biolink:NamedThing negative regulation of nuclear division Any process that stops, prevents, or reduces the frequency, rate or extent of nuclear division, the partitioning of the nucleus and its genetic information. RBO_relaxed.owl GO:0051785 biolink:NamedThing positive regulation of nuclear division Any process that activates or increases the frequency, rate or extent of nuclear division, the partitioning of the nucleus and its genetic information. RBO_relaxed.owl GO:0051890 biolink:NamedThing regulation of cardioblast differentiation Any process that modulates the frequency, rate or extent of cardioblast differentiation, the process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating. RBO_relaxed.owl GO:0051891 biolink:NamedThing positive regulation of cardioblast differentiation Any process that activates or increases the frequency, rate or extent of cardioblast differentiation, the process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating. RBO_relaxed.owl GO:0051892 biolink:NamedThing negative regulation of cardioblast differentiation Any process that stops, prevents, or reduces the frequency, rate or extent of cardioblast differentiation, the process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating. RBO_relaxed.owl GO:0051930 biolink:NamedThing regulation of sensory perception of pain Any process that modulates the frequency, rate or extent of the sensory perception of pain, the series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal. RBO_relaxed.owl GO:0051931 biolink:NamedThing regulation of sensory perception Any process that modulates the frequency, rate or extent of sensory perception, the series of events required for an organism to receive a sensory stimulus, convert it to a molecular signal, and recognize and characterize the signal. RBO_relaxed.owl GO:0051952 biolink:NamedThing regulation of amine transport Any process that modulates the frequency, rate or extent of the directed movement of amines into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. RBO_relaxed.owl GO:0051953 biolink:NamedThing negative regulation of amine transport Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of amines into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. RBO_relaxed.owl GO:0051954 biolink:NamedThing positive regulation of amine transport Any process that activates, maintains or increases the frequency, rate or extent of the directed movement of amines into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. RBO_relaxed.owl GO:0051955 biolink:NamedThing regulation of amino acid transport Any process that modulates the frequency, rate or extent of the directed movement of amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. RBO_relaxed.owl GO:0051956 biolink:NamedThing negative regulation of amino acid transport Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. RBO_relaxed.owl GO:0051957 biolink:NamedThing positive regulation of amino acid transport Any process that activates, maintains or increases the frequency, rate or extent of the directed movement of amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. RBO_relaxed.owl GO:0051960 biolink:NamedThing regulation of nervous system development Any process that modulates the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue. RBO_relaxed.owl GO:0051961 biolink:NamedThing negative regulation of nervous system development Any process that stops, prevents, or reduces the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue. RBO_relaxed.owl GO:0051962 biolink:NamedThing positive regulation of nervous system development Any process that activates, maintains or increases the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue. RBO_relaxed.owl GO:0051963 biolink:NamedThing regulation of synapse assembly Any process that modulates the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse. RBO_relaxed.owl GO:0051964 biolink:NamedThing negative regulation of synapse assembly Any process that stops, prevents, or reduces the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse. RBO_relaxed.owl GO:0051965 biolink:NamedThing positive regulation of synapse assembly Any process that activates, maintains or increases the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse. RBO_relaxed.owl GO:0051969 biolink:NamedThing regulation of transmission of nerve impulse Any process that modulates the frequency, rate or extent of transmission of a nerve impulse, the sequential electrochemical polarization and depolarization that travels across the membrane of a neuron in response to stimulation. RBO_relaxed.owl GO:0051970 biolink:NamedThing negative regulation of transmission of nerve impulse Any process that stops, prevents, or reduces the frequency, rate or extent of transmission of a nerve impulse, the sequential electrochemical polarization and depolarization that travels across the membrane of a neuron in response to stimulation. RBO_relaxed.owl GO:0051971 biolink:NamedThing positive regulation of transmission of nerve impulse Any process that activates, maintains or increases the frequency, rate or extent of transmission of a nerve impulse, the sequential electrochemical polarization and depolarization that travels across the membrane of a neuron in response to stimulation. RBO_relaxed.owl GO:0051983 biolink:NamedThing regulation of chromosome segregation Any process that modulates the frequency, rate or extent of chromosome segregation, the process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets. RBO_relaxed.owl GO:0051984 biolink:NamedThing positive regulation of chromosome segregation Any process that activates or increases the frequency, rate or extent of chromosome segregation, the process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets. RBO_relaxed.owl GO:0051985 biolink:NamedThing negative regulation of chromosome segregation Any process that stops, prevents, or reduces the frequency, rate or extent of chromosome segregation, the process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets. RBO_relaxed.owl GO:0055018 biolink:NamedThing regulation of cardiac muscle fiber development Any process that modulates the frequency, rate or extent of cardiac muscle fiber development. RBO_relaxed.owl GO:0055019 biolink:NamedThing negative regulation of cardiac muscle fiber development Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle fiber development. RBO_relaxed.owl GO:0055020 biolink:NamedThing positive regulation of cardiac muscle fiber development Any process that activates, maintains or increases the frequency, rate or extent of cardiac muscle fiber development. RBO_relaxed.owl GO:0055021 biolink:NamedThing regulation of cardiac muscle tissue growth Any process that modulates the frequency, rate or extent of cardiac muscle growth. RBO_relaxed.owl GO:0055022 biolink:NamedThing negative regulation of cardiac muscle tissue growth Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle growth. RBO_relaxed.owl GO:0055023 biolink:NamedThing positive regulation of cardiac muscle tissue growth Any process that activates, maintains or increases the frequency, rate or extent of cardiac muscle growth. RBO_relaxed.owl GO:0055024 biolink:NamedThing regulation of cardiac muscle tissue development Any process that modulates the frequency, rate or extent of cardiac muscle tissue development. RBO_relaxed.owl GO:0055025 biolink:NamedThing positive regulation of cardiac muscle tissue development Any process that activates, maintains or increases the frequency, rate or extent of cardiac muscle tissue development. RBO_relaxed.owl GO:0055026 biolink:NamedThing negative regulation of cardiac muscle tissue development Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle tissue development. RBO_relaxed.owl GO:0055117 biolink:NamedThing regulation of cardiac muscle contraction Any process that modulates the frequency, rate or extent of cardiac muscle contraction. RBO_relaxed.owl GO:0055118 biolink:NamedThing negative regulation of cardiac muscle contraction Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle contraction. RBO_relaxed.owl GO:0060043 biolink:NamedThing regulation of cardiac muscle cell proliferation Any process that modulates the frequency, rate or extent of cardiac muscle cell proliferation. RBO_relaxed.owl GO:0060044 biolink:NamedThing negative regulation of cardiac muscle cell proliferation Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle cell proliferation. RBO_relaxed.owl GO:0060045 biolink:NamedThing positive regulation of cardiac muscle cell proliferation Any process that activates or increases the frequency, rate or extent of cardiac muscle cell proliferation. RBO_relaxed.owl GO:0060143 biolink:NamedThing positive regulation of syncytium formation by plasma membrane fusion Any process that increases the frequency, rate or extent of the formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells. RBO_relaxed.owl GO:0060251 biolink:NamedThing regulation of glial cell proliferation Any process that modulates the frequency, rate or extent of glial cell proliferation. RBO_relaxed.owl GO:0060252 biolink:NamedThing positive regulation of glial cell proliferation Any process that activates or increases the rate or extent of glial cell proliferation. RBO_relaxed.owl GO:0060253 biolink:NamedThing negative regulation of glial cell proliferation Any process that stops or decreases the rate or extent of glial cell proliferation. RBO_relaxed.owl GO:0060255 biolink:NamedThing regulation of macromolecule metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. RBO_relaxed.owl GO:0060281 biolink:NamedThing regulation of oocyte development Any process that modulates the rate or extent of the process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell. RBO_relaxed.owl GO:0060282 biolink:NamedThing positive regulation of oocyte development Any process that increases the rate or extent of the process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell. RBO_relaxed.owl GO:0060283 biolink:NamedThing negative regulation of oocyte development Any process that decreases the rate or extent of the process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell. RBO_relaxed.owl GO:0060284 biolink:NamedThing regulation of cell development Any process that modulates the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate. RBO_relaxed.owl GO:0060297 biolink:NamedThing regulation of sarcomere organization Any process that modulates the rate, frequency or extent of myofibril assembly by organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs. RBO_relaxed.owl GO:0060298 biolink:NamedThing positive regulation of sarcomere organization Any process that increases the rate, frequency or extent of myofibril assembly by organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs. RBO_relaxed.owl GO:0060299 biolink:NamedThing negative regulation of sarcomere organization Any process that decreases the rate, frequency or extent of myofibril assembly by organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs. RBO_relaxed.owl GO:0060341 biolink:NamedThing regulation of cellular localization Any process that modulates the frequency, rate or extent of a process in which a cell, a substance, or a cellular entity is transported to, or maintained in a specific location within or in the membrane of a cell. RBO_relaxed.owl GO:0060408 biolink:NamedThing regulation of acetylcholine metabolic process Any process that modulates the rate, frequency or extent of the chemical reactions and pathways involving acetylcholine, the acetic acid ester of the organic base choline. Acetylcholine is a major neurotransmitter and neuromodulator both in the central and peripheral nervous systems. It also acts as a paracrine signal in various non-neural tissues. RBO_relaxed.owl GO:0060409 biolink:NamedThing positive regulation of acetylcholine metabolic process Any process that increases the rate, frequency or extent of the chemical reactions and pathways involving acetylcholine, the acetic acid ester of the organic base choline. Acetylcholine is a major neurotransmitter and neuromodulator both in the central and peripheral nervous systems. It also acts as a paracrine signal in various non-neural tissues. RBO_relaxed.owl GO:0060410 biolink:NamedThing negative regulation of acetylcholine metabolic process Any process that decreases the rate, frequency or extent of the chemical reactions and pathways involving acetylcholine, the acetic acid ester of the organic base choline. Acetylcholine is a major neurotransmitter and neuromodulator both in the central and peripheral nervous systems. It also acts as a paracrine signal in various non-neural tissues. RBO_relaxed.owl GO:0060420 biolink:NamedThing regulation of heart growth Any process that modulates the rate or extent of heart growth. Heart growth is the increase in size or mass of the heart. RBO_relaxed.owl GO:0060421 biolink:NamedThing positive regulation of heart growth Any process that increases the rate or extent of heart growth. Heart growth is the increase in size or mass of the heart. RBO_relaxed.owl GO:0060450 biolink:NamedThing positive regulation of hindgut contraction Any process that increases the frequency, rate or extent of muscle contraction of the hindgut, the posterior part of the alimentary canal, including the rectum, and the large intestine. RBO_relaxed.owl GO:0060451 biolink:NamedThing negative regulation of hindgut contraction Any process that decreases the frequency, rate or extent of muscle contraction of the hindgut, the posterior part of the alimentary canal, including the rectum, and the large intestine. RBO_relaxed.owl GO:0060452 biolink:NamedThing positive regulation of cardiac muscle contraction Any process that increases the frequency, rate or extent of cardiac muscle contraction. RBO_relaxed.owl GO:0060453 biolink:NamedThing regulation of gastric acid secretion Any process that modulates the rate frequency or extent of gastric secretion. Gastric secretion is the regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion. RBO_relaxed.owl GO:0060454 biolink:NamedThing positive regulation of gastric acid secretion Any process that increases the rate frequency or extent of gastric secretion. Gastric secretion is the regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion. RBO_relaxed.owl GO:0060455 biolink:NamedThing negative regulation of gastric acid secretion Any process that decreases the rate frequency or extent of gastric secretion. Gastric secretion is the regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion. RBO_relaxed.owl GO:0060456 biolink:NamedThing positive regulation of digestive system process Any process that increases the frequency, rate or extent of a digestive system process, a physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism. RBO_relaxed.owl GO:0060457 biolink:NamedThing negative regulation of digestive system process Any process that decreases the frequency, rate or extent of a digestive system process, a physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism. RBO_relaxed.owl GO:0060467 biolink:NamedThing negative regulation of fertilization Any process that decreases the rate, frequency or extent of fertilization. Fertilization is the union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy). RBO_relaxed.owl GO:0060491 biolink:NamedThing regulation of cell projection assembly Any process that modulates the rate, frequency, or extent of cell projection assembly. RBO_relaxed.owl GO:0060501 biolink:NamedThing positive regulation of epithelial cell proliferation involved in lung morphogenesis Any process that increases the rate or frequency of epithelial cell proliferation that results in the lung attaining its shape. RBO_relaxed.owl GO:0060623 biolink:NamedThing regulation of chromosome condensation Any process that modulates the rate, frequency, or extent of chromosome condensation, the progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells. RBO_relaxed.owl GO:0060627 biolink:NamedThing regulation of vesicle-mediated transport Any process that modulates the rate, frequency, or extent of vesicle-mediated transport, the directed movement of substances, either within a vesicle or in the vesicle membrane, into, out of or within a cell. RBO_relaxed.owl GO:0060632 biolink:NamedThing regulation of microtubule-based movement Any process that modulates the rate, frequency, or extent of microtubule-based movement, the movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. RBO_relaxed.owl GO:0060688 biolink:NamedThing regulation of morphogenesis of a branching structure Any process that modulates the rate, frequency, or extent of branching morphogenesis, the process in which the anatomical structures of branches are generated and organized. RBO_relaxed.owl GO:0061035 biolink:NamedThing regulation of cartilage development Any process that modulates the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate. RBO_relaxed.owl GO:0061036 biolink:NamedThing positive regulation of cartilage development Any process that increases the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate. RBO_relaxed.owl GO:0061037 biolink:NamedThing negative regulation of cartilage development Any process that decreases the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate. RBO_relaxed.owl GO:0061046 biolink:NamedThing regulation of branching involved in lung morphogenesis Any process that modulates the rate, frequency, or extent of the process in which a highly ordered sequence of patterning events generates the branched structures of the lung, consisting of reiterated combinations of bud outgrowth, elongation, and dichotomous subdivision of terminal units. RBO_relaxed.owl GO:0061047 biolink:NamedThing positive regulation of branching involved in lung morphogenesis Any process that increases the rate, frequency, or extent of the process in which a highly ordered sequence of patterning events generates the branched structures of the lung, consisting of reiterated combinations of bud outgrowth, elongation, and dichotomous subdivision of terminal units. RBO_relaxed.owl GO:0061048 biolink:NamedThing negative regulation of branching involved in lung morphogenesis Any process that decreases the rate, frequency, or extent of the process in which a highly ordered sequence of patterning events generates the branched structures of the lung, consisting of reiterated combinations of bud outgrowth, elongation, and dichotomous subdivision of terminal units. RBO_relaxed.owl GO:0061050 biolink:NamedThing regulation of cell growth involved in cardiac muscle cell development Any process that modulates the rate, frequency, or extent of the growth of a cardiac muscle cell, where growth contributes to the progression of the cell over time from its initial formation to its mature state. RBO_relaxed.owl GO:0061051 biolink:NamedThing positive regulation of cell growth involved in cardiac muscle cell development Any process that increases the rate, frequency, or extent of the growth of a cardiac muscle cell, where growth contributes to the progression of the cell over time from its initial formation to its mature state. RBO_relaxed.owl GO:0061052 biolink:NamedThing negative regulation of cell growth involved in cardiac muscle cell development Any process that decreases the rate, frequency, or extent of the growth of a cardiac muscle cell, where growth contributes to the progression of the cell over time from its initial formation to its mature state. RBO_relaxed.owl GO:0061062 biolink:NamedThing regulation of nematode larval development Any process that modulates the rate, frequency, or extent of nematode larval development, the process whose specific outcome is the progression of the nematode larva over time, from its formation to the mature structure. Nematode larval development begins with the newly hatched first-stage larva (L1) and ends with the end of the last larval stage (for example the fourth larval stage (L4) in C. elegans). Each stage of nematode larval development is characterized by proliferation of specific cell lineages and an increase in body size without alteration of the basic body plan. Nematode larval stages are separated by molts in which each stage-specific exoskeleton, or cuticle, is shed and replaced anew. RBO_relaxed.owl GO:0061063 biolink:NamedThing positive regulation of nematode larval development Any process that increases the rate, frequency, or extent of nematode larval development, the process whose specific outcome is the progression of the nematode larva over time, from its formation to the mature structure. Nematode larval development begins with the newly hatched first-stage larva (L1) and ends with the end of the last larval stage (for example the fourth larval stage (L4) in C. elegans). Each stage of nematode larval development is characterized by proliferation of specific cell lineages and an increase in body size without alteration of the basic body plan. Nematode larval stages are separated by molts in which each stage-specific exoskeleton, or cuticle, is shed and replaced anew. RBO_relaxed.owl GO:0061064 biolink:NamedThing negative regulation of nematode larval development Any process that decreases the rate, frequency, or extent of nematode larval development, the process whose specific outcome is the progression of the nematode larva over time, from its formation to the mature structure. Nematode larval development begins with the newly hatched first-stage larva (L1) and ends with the end of the last larval stage (for example the fourth larval stage (L4) in C. elegans). Each stage of nematode larval development is characterized by proliferation of specific cell lineages and an increase in body size without alteration of the basic body plan. Nematode larval stages are separated by molts in which each stage-specific exoskeleton, or cuticle, is shed and replaced anew. RBO_relaxed.owl GO:0061074 biolink:NamedThing regulation of neural retina development Any process that modulates the rate, frequency, or extent of neural retina development, the progression of the neural retina over time from its initial formation to the mature structure. The neural retina is the part of the retina that contains neurons and photoreceptor cells. RBO_relaxed.owl GO:0061075 biolink:NamedThing positive regulation of neural retina development Any process that increases the rate, frequency, or extent of neural retina development, the progression of the neural retina over time from its initial formation to the mature structure. The neural retina is the part of the retina that contains neurons and photoreceptor cells. RBO_relaxed.owl GO:0061076 biolink:NamedThing negative regulation of neural retina development Any process that decreases the rate, frequency, or extent of neural retina development, the progression of the neural retina over time from its initial formation to the mature structure. The neural retina is the part of the retina that contains neurons and photoreceptor cells. RBO_relaxed.owl GO:0061105 biolink:NamedThing regulation of stomach neuroendocrine cell differentiation Any process that modulates the rate, frequency or extent of the differentiation of a neuroendocrine cell in the stomach. RBO_relaxed.owl GO:0061106 biolink:NamedThing negative regulation of stomach neuroendocrine cell differentiation Any process that decreases the rate, frequency or extent of the differentiation of a neuroendocrine cell in the stomach. RBO_relaxed.owl GO:0061117 biolink:NamedThing negative regulation of heart growth Any process that decreases the rate or extent of heart growth. Heart growth is the increase in size or mass of the heart. RBO_relaxed.owl GO:0061181 biolink:NamedThing regulation of chondrocyte development Any process that modulates the rate, frequency, or extent of the process whose specific outcome is the progression of a chondrocyte over time, from its commitment to its mature state. Chondrocyte development does not include the steps involved in committing a chondroblast to a chondrocyte fate. RBO_relaxed.owl GO:0061182 biolink:NamedThing negative regulation of chondrocyte development Any process that decreases the rate, frequency, or extent of the process whose specific outcome is the progression of a chondrocyte over time, from its commitment to its mature state. Chondrocyte development does not include the steps involved in committing a chondroblast to a chondrocyte fate. RBO_relaxed.owl GO:0061183 biolink:NamedThing regulation of dermatome development Any process that modulates the rate, frequency, or extent of the progression of the dermatome over time, from its initial formation to the mature structure. The dermatome is the portion of a somite that will form skin. RBO_relaxed.owl GO:0061184 biolink:NamedThing positive regulation of dermatome development Any process that increases the rate, frequency, or extent of the progression of the dermatome over time, from its initial formation to the mature structure. The dermatome is the portion of a somite that will form skin. RBO_relaxed.owl GO:0061185 biolink:NamedThing negative regulation of dermatome development Any process that decreases the rate, frequency, or extent of the progression of the dermatome over time, from its initial formation to the mature structure. The dermatome is the portion of a somite that will form skin. RBO_relaxed.owl GO:0061189 biolink:NamedThing positive regulation of sclerotome development Any process that increases the rate, frequency, or extent of the progression of the sclerotome over time, from its initial formation to the mature structure. The sclerotome is the portion of the somite that will give rise to a vertebra. RBO_relaxed.owl GO:0061190 biolink:NamedThing regulation of sclerotome development Any process that modulates the rate, frequency, or extent of the progression of the sclerotome over time, from its initial formation to the mature structure. The sclerotome is the portion of the somite that will give rise to a vertebra. RBO_relaxed.owl GO:0061469 biolink:NamedThing regulation of type B pancreatic cell proliferation Any process that modulates the frequency, rate or extent of type B pancreatic cell proliferation. RBO_relaxed.owl GO:0062012 biolink:NamedThing regulation of small molecule metabolic process Any process that modulates the rate, frequency or extent of a small molecule metabolic process. RBO_relaxed.owl GO:0062013 biolink:NamedThing positive regulation of small molecule metabolic process Any process that activates or increases the frequency, rate or extent of a small molecule metabolic process. RBO_relaxed.owl GO:0062014 biolink:NamedThing negative regulation of small molecule metabolic process Any process that stops, prevents or reduces the frequency, rate or extent of a small molecule metabolic process. RBO_relaxed.owl GO:0062033 biolink:NamedThing positive regulation of mitotic sister chromatid segregation Any process that starts or increases the frequency, rate or extent of sister chromatid segregation during mitosis. RBO_relaxed.owl GO:0065009 biolink:NamedThing regulation of molecular function Any process that modulates the frequency, rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding. RBO_relaxed.owl GO:0070092 biolink:NamedThing regulation of glucagon secretion Any process that modulates the frequency, rate or extent of the regulated release of glucagon. RBO_relaxed.owl GO:0070093 biolink:NamedThing negative regulation of glucagon secretion Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of glucagon. RBO_relaxed.owl GO:0070094 biolink:NamedThing positive regulation of glucagon secretion Any process that activates or increases the frequency, rate or extent of the regulated release of glucagon. RBO_relaxed.owl GO:0070201 biolink:NamedThing regulation of establishment of protein localization Any process that modulates the frequency, rate or extent of the directed movement of a protein to a specific location. RBO_relaxed.owl GO:0070202 biolink:NamedThing regulation of establishment of protein localization to chromosome Any process that modulates the frequency, rate or extent of the directed movement of a protein to a specific location on a chromosome. RBO_relaxed.owl GO:0070255 biolink:NamedThing regulation of mucus secretion Any process that modulates the frequency, rate or extent of the regulated release of mucus from a cell or a tissue. RBO_relaxed.owl GO:0070256 biolink:NamedThing negative regulation of mucus secretion Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of mucus from a cell or a tissue. RBO_relaxed.owl GO:0070257 biolink:NamedThing positive regulation of mucus secretion Any process that activates or increases the frequency, rate or extent of the regulated release of mucus from a cell or a tissue. RBO_relaxed.owl GO:0070344 biolink:NamedThing regulation of fat cell proliferation Any process that modulates the frequency, rate or extent of fat cell proliferation. RBO_relaxed.owl GO:0070345 biolink:NamedThing negative regulation of fat cell proliferation Any process that stops or decreases the rate or extent of fat cell proliferation. RBO_relaxed.owl GO:0070346 biolink:NamedThing positive regulation of fat cell proliferation Any process that activates or increases the rate or extent of fat cell proliferation. RBO_relaxed.owl GO:0070366 biolink:NamedThing regulation of hepatocyte differentiation Any process that modulates the frequency, rate or extent of hepatocyte differentiation. RBO_relaxed.owl GO:0070367 biolink:NamedThing negative regulation of hepatocyte differentiation Any process that stops or decreases the rate or extent of hepatocyte differentiation. RBO_relaxed.owl GO:0070368 biolink:NamedThing positive regulation of hepatocyte differentiation Any process that activates or increases the rate or extent of hepatocyte differentiation. RBO_relaxed.owl GO:0070507 biolink:NamedThing regulation of microtubule cytoskeleton organization Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins. RBO_relaxed.owl GO:0070663 biolink:NamedThing regulation of leukocyte proliferation Any process that modulates the frequency, rate or extent of leukocyte proliferation. RBO_relaxed.owl GO:0070664 biolink:NamedThing negative regulation of leukocyte proliferation Any process that stops, prevents, or reduces the frequency, rate or extent of leukocyte proliferation. RBO_relaxed.owl GO:0070665 biolink:NamedThing positive regulation of leukocyte proliferation Any process that activates or increases the frequency, rate or extent of leukocyte proliferation. RBO_relaxed.owl GO:0070857 biolink:NamedThing regulation of bile acid biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of bile acids. RBO_relaxed.owl GO:0070858 biolink:NamedThing negative regulation of bile acid biosynthetic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of bile acids. RBO_relaxed.owl GO:0070859 biolink:NamedThing positive regulation of bile acid biosynthetic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of bile acids. RBO_relaxed.owl GO:0070873 biolink:NamedThing regulation of glycogen metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving glycogen. RBO_relaxed.owl GO:0070874 biolink:NamedThing negative regulation of glycogen metabolic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving glycogen. RBO_relaxed.owl GO:0070875 biolink:NamedThing positive regulation of glycogen metabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving glycogen. RBO_relaxed.owl GO:0072091 biolink:NamedThing regulation of stem cell proliferation Any process that modulates the frequency, rate or extent of stem cell proliferation. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells. RBO_relaxed.owl GO:0072201 biolink:NamedThing negative regulation of mesenchymal cell proliferation Any process that decreases the frequency, rate or extent of mesenchymal cell proliferation. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets. RBO_relaxed.owl GO:0080090 biolink:NamedThing regulation of primary metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism involving those compounds formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism. RBO_relaxed.owl GO:0080134 biolink:NamedThing regulation of response to stress Any process that modulates the frequency, rate or extent of a response to stress. Response to stress is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). RBO_relaxed.owl GO:0080135 biolink:NamedThing regulation of cellular response to stress Any process that modulates the frequency, rate or extent of a cellular response to stress. Cellular response to stress is a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). RBO_relaxed.owl GO:0080154 biolink:NamedThing regulation of fertilization Any process that modulates the rate, frequency or extent of fertilization. Fertilization is the union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy). RBO_relaxed.owl GO:0090063 biolink:NamedThing positive regulation of microtubule nucleation Any process that increases the rate, frequency or extent of microtubule nucleation. Microtubule nucleation is the 'de novo' formation of a microtubule, in which tubulin heterodimers form metastable oligomeric aggregates, some of which go on to support formation of a complete microtubule. Microtubule nucleation usually occurs from a specific site within a cell. RBO_relaxed.owl GO:0090068 biolink:NamedThing positive regulation of cell cycle process Any process that increases the rate, frequency or extent of a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. RBO_relaxed.owl GO:0090069 biolink:NamedThing regulation of ribosome biogenesis Any process that modulates the rate, frequency or extent of ribosome biogenesis. Ribosome biogenesis is the cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits. RBO_relaxed.owl GO:0090070 biolink:NamedThing positive regulation of ribosome biogenesis Any process that increases the rate, frequency or extent of ribosome biogenesis. Ribosome biogenesis is the cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits. RBO_relaxed.owl GO:0090071 biolink:NamedThing negative regulation of ribosome biogenesis Any process that decreases the rate, frequency or extent of ribosome biogenesis. Ribosome biogenesis is the cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits. RBO_relaxed.owl GO:0090087 biolink:NamedThing regulation of peptide transport Any process that modulates the frequency, rate or extent of the directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. RBO_relaxed.owl GO:0090091 biolink:NamedThing positive regulation of extracellular matrix disassembly Any process that increases the rate, frequency or extent of extracellular matrix disassembly. Extracellular matrix disassembly is a process that results in the breakdown of the extracellular matrix. RBO_relaxed.owl GO:0090170 biolink:NamedThing regulation of Golgi inheritance Any process that modulates the rate, frequency or extent of Golgi inheritance. Golgi inheritance is the partitioning of Golgi apparatus between daughter cells at cell division. RBO_relaxed.owl GO:0090257 biolink:NamedThing regulation of muscle system process Any process that modulates the frequency, rate or extent of a muscle system process, a multicellular organismal process carried out by any of the organs or tissues in a muscle system. RBO_relaxed.owl GO:0090273 biolink:NamedThing regulation of somatostatin secretion Any process that modulates the rate, frequency, extent of the regulated release of somatostatin from secretory granules in the D cells of the pancreas. RBO_relaxed.owl GO:0090274 biolink:NamedThing positive regulation of somatostatin secretion Any process that increases the rate, frequency, extent of the regulated release of somatostatin from secretory granules in the D cells of the pancreas. RBO_relaxed.owl GO:0090275 biolink:NamedThing negative regulation of somatostatin secretion Any process that decreases the rate, frequency, extent of the regulated release of somatostatin from secretory granules in the D cells of the pancreas. RBO_relaxed.owl GO:0090276 biolink:NamedThing regulation of peptide hormone secretion Any process that modulates the rate, frequency, or extent of the regulated release of a peptide hormone from secretory granules. RBO_relaxed.owl GO:0090277 biolink:NamedThing positive regulation of peptide hormone secretion Any process that increases the rate, frequency, or extent of the regulated release of a peptide hormone from secretory granules. RBO_relaxed.owl GO:0090278 biolink:NamedThing negative regulation of peptide hormone secretion Any process that decreases the rate, frequency, or extent of the regulated release of a peptide hormone from secretory granules. RBO_relaxed.owl GO:0090299 biolink:NamedThing regulation of neural crest formation Any process that modulates the rate, frequency, or extent of neural crest formation. Neural crest formation is the formation of the specialized region of ectoderm between the neural ectoderm (neural plate) and non-neural ectoderm. The neural crest gives rise to the neural crest cells that migrate away from this region as neural tube formation proceeds. RBO_relaxed.owl GO:0090300 biolink:NamedThing positive regulation of neural crest formation Any process that increases the rate, frequency, or extent of neural crest formation. Neural crest formation is the formation of the specialized region of ectoderm between the neural ectoderm (neural plate) and non-neural ectoderm. The neural crest gives rise to the neural crest cells that migrate away from this region as neural tube formation procedes. RBO_relaxed.owl GO:0090301 biolink:NamedThing negative regulation of neural crest formation Any process that decreases the rate, frequency, or extent of neural crest formation. Neural crest formation is the formation of the specialized region of ectoderm between the neural ectoderm (neural plate) and non-neural ectoderm. The neural crest gives rise to the neural crest cells that migrate away from this region as neural tube formation procedes. RBO_relaxed.owl GO:0090316 biolink:NamedThing positive regulation of intracellular protein transport Any process that activates or increases the frequency, rate or extent of the directed movement of proteins within cells. RBO_relaxed.owl GO:0090317 biolink:NamedThing negative regulation of intracellular protein transport Any process that decreases the frequency, rate or extent of the directed movement of proteins within cells. RBO_relaxed.owl GO:0090325 biolink:NamedThing regulation of locomotion involved in locomotory behavior Any process that modulates the frequency, rate, or extent of the self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement. RBO_relaxed.owl GO:0090327 biolink:NamedThing negative regulation of locomotion involved in locomotory behavior Any process that decreases the frequency, rate, or extent of the self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement. RBO_relaxed.owl GO:0098801 biolink:NamedThing regulation of renal system process Any process that modulates the frequency, rate or extent of a system process, a multicellular organismal process carried out by the renal system. RBO_relaxed.owl GO:0099174 biolink:NamedThing regulation of presynapse organization Any process that modulates the physical form of a presynapse. RBO_relaxed.owl GO:0099175 biolink:NamedThing regulation of postsynapse organization Any process that modulates the physical form of a postsynapse. RBO_relaxed.owl GO:0099177 biolink:NamedThing regulation of trans-synaptic signaling Any process that modulates the frequency, rate or extent of trans-synaptic signaling. RBO_relaxed.owl GO:0099547 biolink:NamedThing regulation of translation at synapse, modulating synaptic transmission Any process that modulates synaptic transmission by regulating translation occurring at the synapse. RBO_relaxed.owl GO:0099574 biolink:NamedThing regulation of protein catabolic process at synapse, modulating synaptic transmission Any process that modulates synaptic transmission by regulating protein degradation at the synapse. RBO_relaxed.owl GO:0099577 biolink:NamedThing regulation of translation at presynapse, modulating synaptic transmission Any process that modulates synaptic transmission by regulating translation occurring at the presynapse. RBO_relaxed.owl GO:0099578 biolink:NamedThing regulation of translation at postsynapse, modulating synaptic transmission Any process that modulates synaptic transmission by regulating translation occurring at the postsynapse. RBO_relaxed.owl GO:0106214 biolink:NamedThing regulation of vesicle fusion with Golgi apparatus Any process that modulates the frequency, rate or extent of vesicle fusion with Golgi apparatus. RBO_relaxed.owl GO:0106215 biolink:NamedThing negative regulation of vesicle fusion with Golgi apparatus Any process that stops, prevents or reduces the frequency, rate or extent of vesicle fustion with Golgi apparatus. RBO_relaxed.owl GO:0106216 biolink:NamedThing positive regulation of vesicle fusion with Golgi apparatus Any process that activates or increases the frequency, rate or extent of vesicle fusion with Golgi apparatus. RBO_relaxed.owl GO:0110011 biolink:NamedThing regulation of basement membrane organization Any process that modulates the frequency, rate or extent of the assembly, disassembly or arrangement of constituent parts of the basement membrane. RBO_relaxed.owl GO:0110020 biolink:NamedThing regulation of actomyosin structure organization Any process that modulates the frequency, rate or extent of the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures containing both actin and myosin or paramyosin. RBO_relaxed.owl GO:0110022 biolink:NamedThing regulation of cardiac muscle myoblast proliferation Any process that modulates the frequency, rate or extent of cardiac muscle myoblast proliferation. RBO_relaxed.owl GO:0110023 biolink:NamedThing negative regulation of cardiac muscle myoblast proliferation Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle myoblast proliferation. RBO_relaxed.owl GO:0110024 biolink:NamedThing positive regulation of cardiac muscle myoblast proliferation Any process that activates or increases the frequency, rate or extent of cardiac muscle myoblast proliferation. RBO_relaxed.owl GO:0110053 biolink:NamedThing regulation of actin filament organization Any process that modulates the frequency, rate or extent of actin filament organization. RBO_relaxed.owl GO:0110057 biolink:NamedThing regulation of blood vessel endothelial cell differentiation Any process that modulates the frequency, rate or extent of blood vessel endothelial cell differentiation. RBO_relaxed.owl GO:0110058 biolink:NamedThing positive regulation of blood vessel endothelial cell differentiation Any process that activates or increases the frequency, rate or extent of blood vessel endothelial cell differentiation. RBO_relaxed.owl GO:0110059 biolink:NamedThing negative regulation of blood vessel endothelial cell differentiation Any process that stops, prevents, or reduces the frequency, rate or extent of blood vessel endothelial cell differentiation. RBO_relaxed.owl GO:0110110 biolink:NamedThing positive regulation of animal organ morphogenesis Any process that activates or increases the frequency, rate or extent of animal organ morphogenesis. RBO_relaxed.owl GO:0110111 biolink:NamedThing negative regulation of animal organ morphogenesis Any process that stops, prevents, or reduces the frequency, rate or extent of animal organ morphogenesis. RBO_relaxed.owl GO:0110112 biolink:NamedThing regulation of lipid transporter activity Any process that modulates the frequency, rate, or extent of lipid transporter activity. RBO_relaxed.owl GO:0110113 biolink:NamedThing positive regulation of lipid transporter activity Any process that increases the frequency, rate, or extent of lipid transporter activity. RBO_relaxed.owl GO:0110114 biolink:NamedThing negative regulation of lipid transporter activity Any process that decreases the frequency, rate, or extent of lipid transporter activity. RBO_relaxed.owl GO:0110116 biolink:NamedThing regulation of compound eye photoreceptor cell differentiation Any process that modulates the frequency, rate or extent of compound eye photoreceptor cell differentiation. RBO_relaxed.owl GO:0110117 biolink:NamedThing positive regulation of compound eye photoreceptor cell differentiation Any process that activates or increases the frequency, rate or extent of compound eye photoreceptor cell differentiation. RBO_relaxed.owl GO:0110118 biolink:NamedThing negative regulation of compound eye photoreceptor cell differentiation Any process that stops, prevents, or reduces the frequency, rate or extent of compound eye photoreceptor cell differentiation. RBO_relaxed.owl GO:0120032 biolink:NamedThing regulation of plasma membrane bounded cell projection assembly Any process that modulates the rate, frequency, or extent of plasma membrane bounded cell projection assembly. RBO_relaxed.owl GO:0120033 biolink:NamedThing negative regulation of plasma membrane bounded cell projection assembly Any process that stops, prevents or reduces the frequency, rate or extent of plasma membrane bounded cell projection assembly. RBO_relaxed.owl GO:0120034 biolink:NamedThing positive regulation of plasma membrane bounded cell projection assembly Any process that activates or increases the frequency, rate or extent of plasma membrane bounded cell projection assembly. RBO_relaxed.owl GO:0120035 biolink:NamedThing regulation of plasma membrane bounded cell projection organization Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of plasma membrane bounded cell projections. RBO_relaxed.owl GO:0120158 biolink:NamedThing positive regulation of collagen catabolic process Any process that activates or increases the frequency, rate or extent of collagen catabolism. Collagen catabolism is the proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix. RBO_relaxed.owl GO:0120186 biolink:NamedThing negative regulation of protein localization to chromatin Any process that stops, prevents, or reduces the frequency, rate or extent of protein localization to chromatin. RBO_relaxed.owl GO:0120187 biolink:NamedThing positive regulation of protein localization to chromatin Any process that activates or increases the frequency, rate or extent of protein localization to chromatin. RBO_relaxed.owl GO:0120188 biolink:NamedThing regulation of bile acid secretion Any process that modulates the frequency, rate or extent of the controlled release of bile acid from a cell or a tissue. RBO_relaxed.owl GO:0120189 biolink:NamedThing positive regulation of bile acid secretion Any process that activates or increases the frequency, rate or extent of the controlled release of bile acid from a cell or a tissue. RBO_relaxed.owl GO:0120190 biolink:NamedThing negative regulation of bile acid secretion Any process that stops, prevents or reduces the frequency, rate or extent of the controlled release of bile acid from a cell or a tissue. RBO_relaxed.owl GO:0120222 biolink:NamedThing regulation of blastocyst development Any process that modulates the frequency, rate or extent of blastocyst development. RBO_relaxed.owl GO:0120305 biolink:NamedThing regulation of pigmentation Any process that modulates the frequency, rate or extent of the deposition or modulates the distribution of coloring matter in an organism. RBO_relaxed.owl GO:0140243 biolink:NamedThing regulation of translation at synapse Any process that regulates translation occurring at the synapse. RBO_relaxed.owl GO:0140244 biolink:NamedThing regulation of translation at presynapse Any process that regulates translation occurring at the presynapse. RBO_relaxed.owl GO:0140245 biolink:NamedThing regulation of translation at postsynapse Any process that regulates translation occurring at the postsynapse. RBO_relaxed.owl GO:0140250 biolink:NamedThing regulation protein catabolic process at synapse Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein at the synapse. RBO_relaxed.owl GO:0140251 biolink:NamedThing regulation protein catabolic process at presynapse Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein at the presynapse. RBO_relaxed.owl GO:0140252 biolink:NamedThing regulation protein catabolic process at postsynapse Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein at the postsynapse. RBO_relaxed.owl GO:0150052 biolink:NamedThing regulation of postsynapse assembly Any process that modulates the frequency, rate or extent of postsynapse assembly, the aggregation, arrangement and bonding together of a set of components to form a postsynapse. RBO_relaxed.owl GO:0150106 biolink:NamedThing regulation of protein localization to cell-cell junction Any process that modulates the frequency, rate or extent of protein localization to cell-cell junction. RBO_relaxed.owl GO:0150107 biolink:NamedThing positive regulation of protein localization to cell-cell junction Any process that activates or increases the frequency, rate or extent of protein localization to cell-cell junction. RBO_relaxed.owl GO:0150111 biolink:NamedThing regulation of transepithelial transport Any process that modulates the frequency, rate or extent of transepithelial transport. RBO_relaxed.owl GO:0150119 biolink:NamedThing negative regulation of protein localization to cell-cell junction Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to cell-cell junction. RBO_relaxed.owl GO:1900117 biolink:NamedThing regulation of execution phase of apoptosis Any process that modulates the frequency, rate or extent of execution phase of apoptosis. RBO_relaxed.owl GO:1900118 biolink:NamedThing negative regulation of execution phase of apoptosis Any process that stops, prevents or reduces the frequency, rate or extent of execution phase of apoptosis. RBO_relaxed.owl GO:1900119 biolink:NamedThing positive regulation of execution phase of apoptosis Any process that activates or increases the frequency, rate or extent of execution phase of apoptosis. RBO_relaxed.owl GO:1900125 biolink:NamedThing regulation of hyaluronan biosynthetic process Any process that modulates the frequency, rate or extent of hyaluronan biosynthetic process. RBO_relaxed.owl GO:1900126 biolink:NamedThing negative regulation of hyaluronan biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of hyaluronan biosynthetic process. RBO_relaxed.owl GO:1900127 biolink:NamedThing positive regulation of hyaluronan biosynthetic process Any process that activates or increases the frequency, rate or extent of hyaluronan biosynthetic process. RBO_relaxed.owl GO:1900180 biolink:NamedThing regulation of protein localization to nucleus Any process that modulates the frequency, rate or extent of protein localization to nucleus. RBO_relaxed.owl GO:1900181 biolink:NamedThing negative regulation of protein localization to nucleus Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to nucleus. RBO_relaxed.owl GO:1900182 biolink:NamedThing positive regulation of protein localization to nucleus Any process that activates or increases the frequency, rate or extent of protein localization to nucleus. RBO_relaxed.owl GO:1900193 biolink:NamedThing regulation of oocyte maturation Any process that modulates the frequency, rate or extent of oocyte maturation. RBO_relaxed.owl GO:1900194 biolink:NamedThing negative regulation of oocyte maturation Any process that stops, prevents or reduces the frequency, rate or extent of oocyte maturation. RBO_relaxed.owl GO:1900195 biolink:NamedThing positive regulation of oocyte maturation Any process that activates or increases the frequency, rate or extent of oocyte maturation. RBO_relaxed.owl GO:1900376 biolink:NamedThing regulation of secondary metabolite biosynthetic process Any process that modulates the frequency, rate or extent of secondary metabolite biosynthetic process. RBO_relaxed.owl GO:1900377 biolink:NamedThing negative regulation of secondary metabolite biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of secondary metabolite biosynthetic process. RBO_relaxed.owl GO:1900378 biolink:NamedThing positive regulation of secondary metabolite biosynthetic process Any process that activates or increases the frequency, rate or extent of secondary metabolite biosynthetic process. RBO_relaxed.owl GO:1901190 biolink:NamedThing regulation of formation of translation initiation ternary complex Any process that modulates the frequency, rate or extent of formation of translation initiation ternary complex. RBO_relaxed.owl GO:1901191 biolink:NamedThing negative regulation of formation of translation initiation ternary complex Any process that stops, prevents or reduces the frequency, rate or extent of formation of translation initiation ternary complex. RBO_relaxed.owl GO:1901192 biolink:NamedThing positive regulation of formation of translation initiation ternary complex Any process that activates or increases the frequency, rate or extent of formation of translation initiation ternary complex. RBO_relaxed.owl GO:1901201 biolink:NamedThing regulation of extracellular matrix assembly Any process that modulates the frequency, rate or extent of extracellular matrix assembly. RBO_relaxed.owl GO:1901202 biolink:NamedThing negative regulation of extracellular matrix assembly Any process that stops, prevents or reduces the frequency, rate or extent of extracellular matrix assembly. RBO_relaxed.owl GO:1901203 biolink:NamedThing positive regulation of extracellular matrix assembly Any process that activates or increases the frequency, rate or extent of extracellular matrix assembly. RBO_relaxed.owl GO:1901210 biolink:NamedThing regulation of cardiac chamber formation Any process that modulates the frequency, rate or extent of cardiac chamber formation. RBO_relaxed.owl GO:1901211 biolink:NamedThing negative regulation of cardiac chamber formation Any process that stops, prevents or reduces the frequency, rate or extent of cardiac chamber formation. RBO_relaxed.owl GO:1901212 biolink:NamedThing positive regulation of cardiac chamber formation Any process that activates or increases the frequency, rate or extent of cardiac chamber formation. RBO_relaxed.owl GO:1901219 biolink:NamedThing regulation of cardiac chamber morphogenesis Any process that modulates the frequency, rate or extent of cardiac chamber morphogenesis. RBO_relaxed.owl GO:1901220 biolink:NamedThing negative regulation of cardiac chamber morphogenesis Any process that stops, prevents or reduces the frequency, rate or extent of cardiac chamber morphogenesis. RBO_relaxed.owl GO:1901221 biolink:NamedThing positive regulation of cardiac chamber morphogenesis Any process that activates or increases the frequency, rate or extent of cardiac chamber morphogenesis. RBO_relaxed.owl GO:1901246 biolink:NamedThing regulation of lung ciliated cell differentiation Any process that modulates the frequency, rate or extent of lung ciliated cell differentiation. RBO_relaxed.owl GO:1901247 biolink:NamedThing negative regulation of lung ciliated cell differentiation Any process that stops, prevents or reduces the frequency, rate or extent of lung ciliated cell differentiation. RBO_relaxed.owl GO:1901248 biolink:NamedThing positive regulation of lung ciliated cell differentiation Any process that activates or increases the frequency, rate or extent of lung ciliated cell differentiation. RBO_relaxed.owl GO:1901342 biolink:NamedThing regulation of vasculature development Any process that modulates the frequency, rate or extent of vasculature development. RBO_relaxed.owl GO:1901343 biolink:NamedThing negative regulation of vasculature development Any process that stops, prevents or reduces the frequency, rate or extent of vasculature development. RBO_relaxed.owl GO:1901401 biolink:NamedThing regulation of tetrapyrrole metabolic process Any process that modulates the frequency, rate or extent of tetrapyrrole metabolic process. RBO_relaxed.owl GO:1901402 biolink:NamedThing negative regulation of tetrapyrrole metabolic process Any process that stops, prevents or reduces the frequency, rate or extent of tetrapyrrole metabolic process. RBO_relaxed.owl GO:1901403 biolink:NamedThing positive regulation of tetrapyrrole metabolic process Any process that activates or increases the frequency, rate or extent of tetrapyrrole metabolic process. RBO_relaxed.owl GO:1901404 biolink:NamedThing regulation of tetrapyrrole catabolic process Any process that modulates the frequency, rate or extent of tetrapyrrole catabolic process. RBO_relaxed.owl GO:1901405 biolink:NamedThing negative regulation of tetrapyrrole catabolic process Any process that stops, prevents or reduces the frequency, rate or extent of tetrapyrrole catabolic process. RBO_relaxed.owl GO:1901406 biolink:NamedThing positive regulation of tetrapyrrole catabolic process Any process that activates or increases the frequency, rate or extent of tetrapyrrole catabolic process. RBO_relaxed.owl GO:1901457 biolink:NamedThing regulation of response to acetate Any process that modulates the frequency, rate or extent of response to acetate. RBO_relaxed.owl GO:1901458 biolink:NamedThing negative regulation of response to acetate Any process that stops, prevents or reduces the frequency, rate or extent of response to acetate. RBO_relaxed.owl GO:1901459 biolink:NamedThing positive regulation of response to acetate Any process that activates or increases the frequency, rate or extent of response to acetate. RBO_relaxed.owl GO:1901463 biolink:NamedThing regulation of tetrapyrrole biosynthetic process Any process that modulates the frequency, rate or extent of tetrapyrrole biosynthetic process. RBO_relaxed.owl GO:1901464 biolink:NamedThing negative regulation of tetrapyrrole biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of tetrapyrrole biosynthetic process. RBO_relaxed.owl GO:1901465 biolink:NamedThing positive regulation of tetrapyrrole biosynthetic process Any process that activates or increases the frequency, rate or extent of tetrapyrrole biosynthetic process. RBO_relaxed.owl GO:1901509 biolink:NamedThing regulation of endothelial tube morphogenesis Any process that modulates the frequency, rate or extent of endothelial tube morphogenesis. RBO_relaxed.owl GO:1901532 biolink:NamedThing regulation of hematopoietic progenitor cell differentiation Any process that modulates the frequency, rate or extent of hematopoietic progenitor cell differentiation. RBO_relaxed.owl GO:1901533 biolink:NamedThing negative regulation of hematopoietic progenitor cell differentiation Any process that stops, prevents or reduces the frequency, rate or extent of hematopoietic progenitor cell differentiation. RBO_relaxed.owl GO:1901534 biolink:NamedThing positive regulation of hematopoietic progenitor cell differentiation Any process that activates or increases the frequency, rate or extent of hematopoietic progenitor cell differentiation. RBO_relaxed.owl GO:1901550 biolink:NamedThing regulation of endothelial cell development Any process that modulates the frequency, rate or extent of endothelial cell development. RBO_relaxed.owl GO:1901551 biolink:NamedThing negative regulation of endothelial cell development Any process that stops, prevents or reduces the frequency, rate or extent of endothelial cell development. RBO_relaxed.owl GO:1901552 biolink:NamedThing positive regulation of endothelial cell development Any process that activates or increases the frequency, rate or extent of endothelial cell development. RBO_relaxed.owl GO:1901608 biolink:NamedThing regulation of vesicle transport along microtubule Any process that modulates the frequency, rate or extent of vesicle transport along microtubule. RBO_relaxed.owl GO:1901609 biolink:NamedThing negative regulation of vesicle transport along microtubule Any process that stops, prevents or reduces the frequency, rate or extent of vesicle transport along microtubule. RBO_relaxed.owl GO:1901610 biolink:NamedThing positive regulation of vesicle transport along microtubule Any process that activates or increases the frequency, rate or extent of vesicle transport along microtubule. RBO_relaxed.owl GO:1901692 biolink:NamedThing regulation of compound eye retinal cell apoptotic process Any process that modulates the frequency, rate or extent of compound eye retinal cell apoptotic process. RBO_relaxed.owl GO:1901693 biolink:NamedThing negative regulation of compound eye retinal cell apoptotic process Any process that stops, prevents or reduces the frequency, rate or extent of compound eye retinal cell apoptotic process. RBO_relaxed.owl GO:1901694 biolink:NamedThing positive regulation of compound eye retinal cell apoptotic process Any process that activates or increases the frequency, rate or extent of compound eye retinal cell apoptotic process. RBO_relaxed.owl GO:1901861 biolink:NamedThing regulation of muscle tissue development Any process that modulates the frequency, rate or extent of muscle tissue development. RBO_relaxed.owl GO:1901862 biolink:NamedThing negative regulation of muscle tissue development Any process that stops, prevents or reduces the frequency, rate or extent of muscle tissue development. RBO_relaxed.owl GO:1901863 biolink:NamedThing positive regulation of muscle tissue development Any process that activates or increases the frequency, rate or extent of muscle tissue development. RBO_relaxed.owl GO:1901879 biolink:NamedThing regulation of protein depolymerization Any process that modulates the frequency, rate or extent of protein depolymerization. RBO_relaxed.owl GO:1901880 biolink:NamedThing negative regulation of protein depolymerization Any process that stops, prevents or reduces the frequency, rate or extent of protein depolymerization. RBO_relaxed.owl GO:1901881 biolink:NamedThing positive regulation of protein depolymerization Any process that activates or increases the frequency, rate or extent of protein depolymerization. RBO_relaxed.owl GO:1901889 biolink:NamedThing negative regulation of cell junction assembly Any process that stops, prevents or reduces the frequency, rate or extent of cell junction assembly. RBO_relaxed.owl GO:1901890 biolink:NamedThing positive regulation of cell junction assembly Any process that activates or increases the frequency, rate or extent of cell junction assembly. RBO_relaxed.owl GO:1901963 biolink:NamedThing regulation of cell proliferation involved in outflow tract morphogenesis Any process that modulates the frequency, rate or extent of cell proliferation involved in outflow tract morphogenesis. RBO_relaxed.owl GO:1901964 biolink:NamedThing positive regulation of cell proliferation involved in outflow tract morphogenesis Any process that activates or increases the frequency, rate or extent of cell proliferation involved in outflow tract morphogenesis. RBO_relaxed.owl GO:1902017 biolink:NamedThing regulation of cilium assembly Any process that modulates the frequency, rate or extent of cilium assembly. RBO_relaxed.owl GO:1902018 biolink:NamedThing negative regulation of cilium assembly Any process that stops, prevents or reduces the frequency, rate or extent of cilium assembly. RBO_relaxed.owl GO:1902033 biolink:NamedThing regulation of hematopoietic stem cell proliferation Any process that modulates the frequency, rate or extent of hematopoietic stem cell proliferation. RBO_relaxed.owl GO:1902034 biolink:NamedThing negative regulation of hematopoietic stem cell proliferation Any process that stops, prevents or reduces the frequency, rate or extent of hematopoietic stem cell proliferation. RBO_relaxed.owl GO:1902035 biolink:NamedThing positive regulation of hematopoietic stem cell proliferation Any process that activates or increases the frequency, rate or extent of hematopoietic stem cell proliferation. RBO_relaxed.owl GO:1902036 biolink:NamedThing regulation of hematopoietic stem cell differentiation Any process that modulates the frequency, rate or extent of hematopoietic stem cell differentiation. RBO_relaxed.owl GO:1902037 biolink:NamedThing negative regulation of hematopoietic stem cell differentiation Any process that stops, prevents or reduces the frequency, rate or extent of hematopoietic stem cell differentiation. RBO_relaxed.owl GO:1902038 biolink:NamedThing positive regulation of hematopoietic stem cell differentiation Any process that activates or increases the frequency, rate or extent of hematopoietic stem cell differentiation. RBO_relaxed.owl GO:1902105 biolink:NamedThing regulation of leukocyte differentiation Any process that modulates the frequency, rate or extent of leukocyte differentiation. RBO_relaxed.owl GO:1902106 biolink:NamedThing negative regulation of leukocyte differentiation Any process that stops, prevents or reduces the frequency, rate or extent of leukocyte differentiation. RBO_relaxed.owl GO:1902107 biolink:NamedThing positive regulation of leukocyte differentiation Any process that activates or increases the frequency, rate or extent of leukocyte differentiation. RBO_relaxed.owl GO:1902115 biolink:NamedThing regulation of organelle assembly Any process that modulates the frequency, rate or extent of organelle assembly. RBO_relaxed.owl GO:1902116 biolink:NamedThing negative regulation of organelle assembly Any process that stops, prevents or reduces the frequency, rate or extent of organelle assembly. RBO_relaxed.owl GO:1902117 biolink:NamedThing positive regulation of organelle assembly Any process that activates or increases the frequency, rate or extent of organelle assembly. RBO_relaxed.owl GO:1902250 biolink:NamedThing regulation of erythrocyte apoptotic process Any process that modulates the frequency, rate or extent of erythrocyte apoptotic process. RBO_relaxed.owl GO:1902251 biolink:NamedThing negative regulation of erythrocyte apoptotic process Any process that stops, prevents or reduces the frequency, rate or extent of erythrocyte apoptotic process. RBO_relaxed.owl GO:1902252 biolink:NamedThing positive regulation of erythrocyte apoptotic process Any process that activates or increases the frequency, rate or extent of erythrocyte apoptotic process. RBO_relaxed.owl GO:1902256 biolink:NamedThing regulation of apoptotic process involved in outflow tract morphogenesis Any process that modulates the frequency, rate or extent of apoptotic process involved in outflow tract morphogenesis. RBO_relaxed.owl GO:1902257 biolink:NamedThing negative regulation of apoptotic process involved in outflow tract morphogenesis Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic process involved in outflow tract morphogenesis. RBO_relaxed.owl GO:1902258 biolink:NamedThing positive regulation of apoptotic process involved in outflow tract morphogenesis Any process that activates or increases the frequency, rate or extent of apoptotic process involved in outflow tract morphogenesis. RBO_relaxed.owl GO:1902305 biolink:NamedThing regulation of sodium ion transmembrane transport Any process that modulates the frequency, rate or extent of sodium ion transmembrane transport. RBO_relaxed.owl GO:1902306 biolink:NamedThing negative regulation of sodium ion transmembrane transport Any process that stops, prevents or reduces the frequency, rate or extent of sodium ion transmembrane transport. RBO_relaxed.owl GO:1902307 biolink:NamedThing positive regulation of sodium ion transmembrane transport Any process that activates or increases the frequency, rate or extent of sodium ion transmembrane transport. RBO_relaxed.owl GO:1902337 biolink:NamedThing regulation of apoptotic process involved in morphogenesis Any process that modulates the frequency, rate or extent of apoptotic process involved in morphogenesis. RBO_relaxed.owl GO:1902338 biolink:NamedThing negative regulation of apoptotic process involved in morphogenesis Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic process involved in morphogenesis. RBO_relaxed.owl GO:1902339 biolink:NamedThing positive regulation of apoptotic process involved in morphogenesis Any process that activates or increases the frequency, rate or extent of apoptotic process involved in morphogenesis. RBO_relaxed.owl GO:1902340 biolink:NamedThing negative regulation of chromosome condensation Any process that stops, prevents or reduces the frequency, rate or extent of chromosome condensation. RBO_relaxed.owl GO:1902369 biolink:NamedThing negative regulation of RNA catabolic process Any process that stops, prevents or reduces the frequency, rate or extent of RNA catabolic process. RBO_relaxed.owl GO:1902473 biolink:NamedThing regulation of protein localization to synapse Any process that modulates the frequency, rate or extent of protein localization to synapse. RBO_relaxed.owl GO:1902474 biolink:NamedThing positive regulation of protein localization to synapse Any process that activates or increases the frequency, rate or extent of protein localization to synapse. RBO_relaxed.owl GO:1902510 biolink:NamedThing regulation of apoptotic DNA fragmentation Any process that modulates the frequency, rate or extent of apoptotic DNA fragmentation. RBO_relaxed.owl GO:1902511 biolink:NamedThing negative regulation of apoptotic DNA fragmentation Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic DNA fragmentation. RBO_relaxed.owl GO:1902512 biolink:NamedThing positive regulation of apoptotic DNA fragmentation Any process that activates or increases the frequency, rate or extent of apoptotic DNA fragmentation. RBO_relaxed.owl GO:1902513 biolink:NamedThing regulation of organelle transport along microtubule Any process that modulates the frequency, rate or extent of organelle transport along microtubule. RBO_relaxed.owl GO:1902531 biolink:NamedThing regulation of intracellular signal transduction Any process that modulates the frequency, rate or extent of intracellular signal transduction. RBO_relaxed.owl GO:1902532 biolink:NamedThing negative regulation of intracellular signal transduction Any process that stops, prevents or reduces the frequency, rate or extent of intracellular signal transduction. RBO_relaxed.owl GO:1902533 biolink:NamedThing positive regulation of intracellular signal transduction Any process that activates or increases the frequency, rate or extent of intracellular signal transduction. RBO_relaxed.owl GO:1902679 biolink:NamedThing negative regulation of RNA biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of RNA biosynthetic process. RBO_relaxed.owl GO:1902680 biolink:NamedThing positive regulation of RNA biosynthetic process Any process that activates or increases the frequency, rate or extent of RNA biosynthetic process. RBO_relaxed.owl GO:1902692 biolink:NamedThing regulation of neuroblast proliferation Any process that modulates the frequency, rate or extent of neuroblast proliferation. RBO_relaxed.owl GO:1902738 biolink:NamedThing regulation of chondrocyte differentiation involved in endochondral bone morphogenesis Any process that modulates the rate, frequency, or extent of the process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte that will contribute to the development of a bone. A chondrocyte is a polymorphic cell that forms cartilage. RBO_relaxed.owl GO:1902761 biolink:NamedThing positive regulation of chondrocyte development Any process that activates or increases the frequency, rate or extent of chondrocyte development. RBO_relaxed.owl GO:1902809 biolink:NamedThing regulation of skeletal muscle fiber differentiation Any process that modulates the frequency, rate or extent of skeletal muscle fiber differentiation. RBO_relaxed.owl GO:1902810 biolink:NamedThing negative regulation of skeletal muscle fiber differentiation Any process that stops, prevents or reduces the frequency, rate or extent of skeletal muscle fiber differentiation. RBO_relaxed.owl GO:1902811 biolink:NamedThing positive regulation of skeletal muscle fiber differentiation Any process that activates or increases the frequency, rate or extent of skeletal muscle fiber differentiation. RBO_relaxed.owl GO:1902816 biolink:NamedThing regulation of protein localization to microtubule Any process that modulates the frequency, rate or extent of protein localization to microtubule. RBO_relaxed.owl GO:1902817 biolink:NamedThing negative regulation of protein localization to microtubule Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to microtubule. RBO_relaxed.owl GO:1902838 biolink:NamedThing regulation of nuclear migration along microtubule Any process that modulates the frequency, rate or extent of nuclear migration along microtubule. RBO_relaxed.owl GO:1902839 biolink:NamedThing negative regulation of nuclear migration along microtubule Any process that stops, prevents or reduces the frequency, rate or extent of nuclear migration along microtubule. RBO_relaxed.owl GO:1902840 biolink:NamedThing positive regulation of nuclear migration along microtubule Any process that activates or increases the frequency, rate or extent of nuclear migration along microtubule. RBO_relaxed.owl GO:1902863 biolink:NamedThing regulation of embryonic camera-type eye development Any process that modulates the frequency, rate or extent of embryonic camera-type eye development. RBO_relaxed.owl GO:1902864 biolink:NamedThing negative regulation of embryonic camera-type eye development Any process that stops, prevents or reduces the frequency, rate or extent of embryonic camera-type eye development. RBO_relaxed.owl GO:1902865 biolink:NamedThing positive regulation of embryonic camera-type eye development Any process that activates or increases the frequency, rate or extent of embryonic camera-type eye development. RBO_relaxed.owl GO:1902866 biolink:NamedThing regulation of retina development in camera-type eye Any process that modulates the frequency, rate or extent of retina development in camera-type eye. RBO_relaxed.owl GO:1902867 biolink:NamedThing negative regulation of retina development in camera-type eye Any process that stops, prevents or reduces the frequency, rate or extent of retina development in camera-type eye. RBO_relaxed.owl GO:1902868 biolink:NamedThing positive regulation of retina development in camera-type eye Any process that activates or increases the frequency, rate or extent of retina development in camera-type eye. RBO_relaxed.owl GO:1902904 biolink:NamedThing negative regulation of supramolecular fiber organization Any process that stops, prevents or reduces the frequency, rate or extent of fibril organization. RBO_relaxed.owl GO:1902905 biolink:NamedThing positive regulation of supramolecular fiber organization Any process that activates or increases the frequency, rate or extent of supramolecular fiber organization. RBO_relaxed.owl GO:1902913 biolink:NamedThing positive regulation of neuroepithelial cell differentiation Any process that activates or increases the frequency, rate or extent of neuroepithelial cell differentiation. RBO_relaxed.owl GO:1903010 biolink:NamedThing regulation of bone development Any process that modulates the frequency, rate or extent of bone development. RBO_relaxed.owl GO:1903011 biolink:NamedThing negative regulation of bone development Any process that stops, prevents or reduces the frequency, rate or extent of bone development. RBO_relaxed.owl GO:1903012 biolink:NamedThing positive regulation of bone development Any process that activates or increases the frequency, rate or extent of bone development. RBO_relaxed.owl GO:1903018 biolink:NamedThing regulation of glycoprotein metabolic process Any process that modulates the frequency, rate or extent of glycoprotein metabolic process. RBO_relaxed.owl GO:1903019 biolink:NamedThing negative regulation of glycoprotein metabolic process Any process that stops, prevents or reduces the frequency, rate or extent of glycoprotein metabolic process. RBO_relaxed.owl GO:1903020 biolink:NamedThing positive regulation of glycoprotein metabolic process Any process that activates or increases the frequency, rate or extent of glycoprotein metabolic process. RBO_relaxed.owl GO:1903054 biolink:NamedThing negative regulation of extracellular matrix organization Any process that stops, prevents or reduces the frequency, rate or extent of extracellular matrix organization. RBO_relaxed.owl GO:1903055 biolink:NamedThing positive regulation of extracellular matrix organization Any process that activates or increases the frequency, rate or extent of extracellular matrix organization. RBO_relaxed.owl GO:1903076 biolink:NamedThing regulation of protein localization to plasma membrane Any process that modulates the frequency, rate or extent of protein localization to plasma membrane. RBO_relaxed.owl GO:1903077 biolink:NamedThing negative regulation of protein localization to plasma membrane Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to plasma membrane. RBO_relaxed.owl GO:1903078 biolink:NamedThing positive regulation of protein localization to plasma membrane Any process that activates or increases the frequency, rate or extent of protein localization to plasma membrane. RBO_relaxed.owl GO:1903115 biolink:NamedThing regulation of actin filament-based movement Any process that modulates the frequency, rate or extent of actin filament-based movement. RBO_relaxed.owl GO:1903116 biolink:NamedThing positive regulation of actin filament-based movement Any process that activates or increases the frequency, rate or extent of actin filament-based movement. RBO_relaxed.owl GO:1903224 biolink:NamedThing regulation of endodermal cell differentiation Any process that modulates the frequency, rate or extent of endodermal cell differentiation. RBO_relaxed.owl GO:1903225 biolink:NamedThing negative regulation of endodermal cell differentiation Any process that stops, prevents or reduces the frequency, rate or extent of endodermal cell differentiation. RBO_relaxed.owl GO:1903226 biolink:NamedThing positive regulation of endodermal cell differentiation Any process that activates or increases the frequency, rate or extent of endodermal cell differentiation. RBO_relaxed.owl GO:1903335 biolink:NamedThing regulation of vacuolar transport Any process that modulates the frequency, rate or extent of vacuolar transport. RBO_relaxed.owl GO:1903336 biolink:NamedThing negative regulation of vacuolar transport Any process that stops, prevents or reduces the frequency, rate or extent of vacuolar transport. RBO_relaxed.owl GO:1903337 biolink:NamedThing positive regulation of vacuolar transport Any process that activates or increases the frequency, rate or extent of vacuolar transport. RBO_relaxed.owl GO:1903353 biolink:NamedThing regulation of nucleus organization Any process that modulates the frequency, rate or extent of nucleus organization. RBO_relaxed.owl GO:1903358 biolink:NamedThing regulation of Golgi organization Any process that modulates the frequency, rate or extent of Golgi organization. RBO_relaxed.owl GO:1903379 biolink:NamedThing regulation of mitotic chromosome condensation Any process that modulates the frequency, rate or extent of mitotic chromosome condensation. RBO_relaxed.owl GO:1903380 biolink:NamedThing positive regulation of mitotic chromosome condensation Any process that activates or increases the frequency, rate or extent of mitotic chromosome condensation. RBO_relaxed.owl GO:1903429 biolink:NamedThing regulation of cell maturation Any process that modulates the frequency, rate or extent of cell maturation. RBO_relaxed.owl GO:1903430 biolink:NamedThing negative regulation of cell maturation Any process that stops, prevents or reduces the frequency, rate or extent of cell maturation. RBO_relaxed.owl GO:1903431 biolink:NamedThing positive regulation of cell maturation Any process that activates or increases the frequency, rate or extent of cell maturation. RBO_relaxed.owl GO:1903522 biolink:NamedThing regulation of blood circulation Any process that modulates the frequency, rate or extent of blood circulation. RBO_relaxed.owl GO:1903523 biolink:NamedThing negative regulation of blood circulation Any process that stops, prevents or reduces the frequency, rate or extent of blood circulation. RBO_relaxed.owl GO:1903524 biolink:NamedThing positive regulation of blood circulation Any process that activates or increases the frequency, rate or extent of blood circulation. RBO_relaxed.owl GO:1903530 biolink:NamedThing regulation of secretion by cell Any process that modulates the frequency, rate or extent of secretion by cell. RBO_relaxed.owl GO:1903531 biolink:NamedThing negative regulation of secretion by cell Any process that stops, prevents or reduces the frequency, rate or extent of secretion by cell. RBO_relaxed.owl GO:1903532 biolink:NamedThing positive regulation of secretion by cell Any process that activates or increases the frequency, rate or extent of secretion by cell. RBO_relaxed.owl GO:1903538 biolink:NamedThing regulation of meiotic cell cycle process involved in oocyte maturation Any process that modulates the frequency, rate or extent of meiotic cell cycle process involved in oocyte maturation. RBO_relaxed.owl GO:1903541 biolink:NamedThing regulation of exosomal secretion Any process that modulates the frequency, rate or extent of exosomal secretion. RBO_relaxed.owl GO:1903542 biolink:NamedThing negative regulation of exosomal secretion Any process that stops, prevents or reduces the frequency, rate or extent of exosomal secretion. RBO_relaxed.owl GO:1903543 biolink:NamedThing positive regulation of exosomal secretion Any process that activates or increases the frequency, rate or extent of exosomal secretion. RBO_relaxed.owl GO:1903551 biolink:NamedThing regulation of extracellular exosome assembly Any process that modulates the frequency, rate or extent of extracellular vesicular exosome assembly. RBO_relaxed.owl GO:1903552 biolink:NamedThing negative regulation of extracellular exosome assembly Any process that stops, prevents or reduces the frequency, rate or extent of extracellular vesicular exosome assembly. RBO_relaxed.owl GO:1903553 biolink:NamedThing positive regulation of extracellular exosome assembly Any process that activates or increases the frequency, rate or extent of extracellular vesicular exosome assembly. RBO_relaxed.owl GO:1903564 biolink:NamedThing regulation of protein localization to cilium Any process that modulates the frequency, rate or extent of protein localization to cilium. RBO_relaxed.owl GO:1903565 biolink:NamedThing negative regulation of protein localization to cilium Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to cilium. RBO_relaxed.owl GO:1903566 biolink:NamedThing positive regulation of protein localization to cilium Any process that activates or increases the frequency, rate or extent of protein localization to cilium. RBO_relaxed.owl GO:1903567 biolink:NamedThing regulation of protein localization to ciliary membrane Any process that modulates the frequency, rate or extent of protein localization to ciliary membrane. RBO_relaxed.owl GO:1903568 biolink:NamedThing negative regulation of protein localization to ciliary membrane Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to ciliary membrane. RBO_relaxed.owl GO:1903569 biolink:NamedThing positive regulation of protein localization to ciliary membrane Any process that activates or increases the frequency, rate or extent of protein localization to ciliary membrane. RBO_relaxed.owl GO:1903624 biolink:NamedThing regulation of DNA catabolic process Any process that modulates the frequency, rate or extent of DNA catabolic process. RBO_relaxed.owl GO:1903625 biolink:NamedThing negative regulation of DNA catabolic process Any process that stops, prevents or reduces the frequency, rate or extent of DNA catabolic process. RBO_relaxed.owl GO:1903626 biolink:NamedThing positive regulation of DNA catabolic process Any process that activates or increases the frequency, rate or extent of DNA catabolic process. RBO_relaxed.owl GO:1903697 biolink:NamedThing negative regulation of microvillus assembly Any process that stops, prevents or reduces the frequency, rate or extent of microvillus assembly. RBO_relaxed.owl GO:1903698 biolink:NamedThing positive regulation of microvillus assembly Any process that activates or increases the frequency, rate or extent of microvillus assembly. RBO_relaxed.owl GO:1903706 biolink:NamedThing regulation of hemopoiesis Any process that modulates the frequency, rate or extent of hemopoiesis. RBO_relaxed.owl GO:1903707 biolink:NamedThing negative regulation of hemopoiesis Any process that stops, prevents or reduces the frequency, rate or extent of hemopoiesis. RBO_relaxed.owl GO:1903708 biolink:NamedThing positive regulation of hemopoiesis Any process that activates or increases the frequency, rate or extent of hemopoiesis. RBO_relaxed.owl GO:1903779 biolink:NamedThing regulation of cardiac conduction Any process that modulates the frequency, rate or extent of cardiac conduction. RBO_relaxed.owl GO:1903780 biolink:NamedThing negative regulation of cardiac conduction Any process that stops, prevents or reduces the frequency, rate or extent of cardiac conduction. RBO_relaxed.owl GO:1903781 biolink:NamedThing positive regulation of cardiac conduction Any process that activates or increases the frequency, rate or extent of cardiac conduction. RBO_relaxed.owl GO:1903789 biolink:NamedThing regulation of amino acid transmembrane transport Any process that modulates the frequency, rate or extent of amino acid transmembrane transport. RBO_relaxed.owl GO:1903795 biolink:NamedThing regulation of inorganic anion transmembrane transport Any process that modulates the frequency, rate or extent of inorganic anion transmembrane transport. RBO_relaxed.owl GO:1903796 biolink:NamedThing negative regulation of inorganic anion transmembrane transport Any process that stops, prevents or reduces the frequency, rate or extent of inorganic anion transmembrane transport. RBO_relaxed.owl GO:1903797 biolink:NamedThing positive regulation of inorganic anion transmembrane transport Any process that activates or increases the frequency, rate or extent of inorganic anion transmembrane transport. RBO_relaxed.owl GO:1903828 biolink:NamedThing negative regulation of protein localization Any process that stops, prevents or reduces the frequency, rate or extent of a protein localization. RBO_relaxed.owl GO:1903829 biolink:NamedThing positive regulation of protein localization Any process that activates or increases the frequency, rate or extent of a protein localization. RBO_relaxed.owl GO:1903847 biolink:NamedThing regulation of aorta morphogenesis Any process that modulates the frequency, rate or extent of aorta morphogenesis. RBO_relaxed.owl GO:1903848 biolink:NamedThing negative regulation of aorta morphogenesis Any process that stops, prevents or reduces the frequency, rate or extent of aorta morphogenesis. RBO_relaxed.owl GO:1903849 biolink:NamedThing positive regulation of aorta morphogenesis Any process that activates or increases the frequency, rate or extent of aorta morphogenesis. RBO_relaxed.owl GO:1903941 biolink:NamedThing negative regulation of respiratory gaseous exchange Any process that stops, prevents or reduces the frequency, rate or extent of respiratory gaseous exchange. RBO_relaxed.owl GO:1903942 biolink:NamedThing positive regulation of respiratory gaseous exchange Any process that activates or increases the frequency, rate or extent of respiratory gaseous exchange. RBO_relaxed.owl GO:1903943 biolink:NamedThing regulation of hepatocyte apoptotic process Any process that modulates the frequency, rate or extent of hepatocyte apoptotic process. RBO_relaxed.owl GO:1903944 biolink:NamedThing negative regulation of hepatocyte apoptotic process Any process that stops, prevents or reduces the frequency, rate or extent of hepatocyte apoptotic process. RBO_relaxed.owl GO:1903945 biolink:NamedThing positive regulation of hepatocyte apoptotic process Any process that activates or increases the frequency, rate or extent of hepatocyte apoptotic process. RBO_relaxed.owl GO:1903950 biolink:NamedThing negative regulation of AV node cell action potential Any process that stops, prevents or reduces the frequency, rate or extent of AV node cell action potential. RBO_relaxed.owl GO:1903951 biolink:NamedThing positive regulation of AV node cell action potential Any process that activates or increases the frequency, rate or extent of AV node cell action potential. RBO_relaxed.owl GO:1904018 biolink:NamedThing positive regulation of vasculature development Any process that activates or increases the frequency, rate or extent of vasculature development. RBO_relaxed.owl GO:1904026 biolink:NamedThing regulation of collagen fibril organization Any process that modulates the frequency, rate or extent of collagen fibril organization. RBO_relaxed.owl GO:1904027 biolink:NamedThing negative regulation of collagen fibril organization Any process that stops, prevents or reduces the frequency, rate or extent of collagen fibril organization. RBO_relaxed.owl GO:1904028 biolink:NamedThing positive regulation of collagen fibril organization Any process that activates or increases the frequency, rate or extent of collagen fibril organization. RBO_relaxed.owl GO:1904035 biolink:NamedThing regulation of epithelial cell apoptotic process Any process that modulates the frequency, rate or extent of epithelial cell apoptotic process. RBO_relaxed.owl GO:1904036 biolink:NamedThing negative regulation of epithelial cell apoptotic process Any process that stops, prevents or reduces the frequency, rate or extent of epithelial cell apoptotic process. RBO_relaxed.owl GO:1904037 biolink:NamedThing positive regulation of epithelial cell apoptotic process Any process that activates or increases the frequency, rate or extent of epithelial cell apoptotic process. RBO_relaxed.owl GO:1904054 biolink:NamedThing regulation of cholangiocyte proliferation Any process that modulates the frequency, rate or extent of cholangiocyte proliferation. RBO_relaxed.owl GO:1904055 biolink:NamedThing negative regulation of cholangiocyte proliferation Any process that stops, prevents or reduces the frequency, rate or extent of cholangiocyte proliferation. RBO_relaxed.owl GO:1904056 biolink:NamedThing positive regulation of cholangiocyte proliferation Any process that activates or increases the frequency, rate or extent of cholangiocyte proliferation. RBO_relaxed.owl GO:1904057 biolink:NamedThing negative regulation of sensory perception of pain Any process that stops, prevents or reduces the frequency, rate or extent of sensory perception of pain. RBO_relaxed.owl GO:1904058 biolink:NamedThing positive regulation of sensory perception of pain Any process that activates or increases the frequency, rate or extent of sensory perception of pain. RBO_relaxed.owl GO:1904062 biolink:NamedThing regulation of monoatomic cation transmembrane transport Any process that modulates the frequency, rate or extent of cation transmembrane transport. RBO_relaxed.owl GO:1904063 biolink:NamedThing negative regulation of cation transmembrane transport Any process that stops, prevents or reduces the frequency, rate or extent of cation transmembrane transport. RBO_relaxed.owl GO:1904064 biolink:NamedThing positive regulation of cation transmembrane transport Any process that activates or increases the frequency, rate or extent of cation transmembrane transport. RBO_relaxed.owl GO:1904073 biolink:NamedThing regulation of trophectodermal cell proliferation Any process that modulates the frequency, rate or extent of trophectodermal cell proliferation. RBO_relaxed.owl GO:1904074 biolink:NamedThing negative regulation of trophectodermal cell proliferation Any process that stops, prevents or reduces the frequency, rate or extent of trophectodermal cell proliferation. RBO_relaxed.owl GO:1904075 biolink:NamedThing positive regulation of trophectodermal cell proliferation Any process that activates or increases the frequency, rate or extent of trophectodermal cell proliferation. RBO_relaxed.owl GO:1904145 biolink:NamedThing negative regulation of meiotic cell cycle process involved in oocyte maturation Any process that stops, prevents or reduces the frequency, rate or extent of meiotic cell cycle process involved in oocyte maturation. RBO_relaxed.owl GO:1904146 biolink:NamedThing positive regulation of meiotic cell cycle process involved in oocyte maturation Any process that activates or increases the frequency, rate or extent of meiotic cell cycle process involved in oocyte maturation. RBO_relaxed.owl GO:1904170 biolink:NamedThing regulation of bleb assembly Any process that modulates the frequency, rate or extent of bleb assembly. RBO_relaxed.owl GO:1904171 biolink:NamedThing negative regulation of bleb assembly Any process that stops, prevents or reduces the frequency, rate or extent of bleb assembly. RBO_relaxed.owl GO:1904172 biolink:NamedThing positive regulation of bleb assembly Any process that activates or increases the frequency, rate or extent of bleb assembly. RBO_relaxed.owl GO:1904177 biolink:NamedThing regulation of adipose tissue development Any process that modulates the frequency, rate or extent of adipose tissue development. RBO_relaxed.owl GO:1904178 biolink:NamedThing negative regulation of adipose tissue development Any process that stops, prevents or reduces the frequency, rate or extent of adipose tissue development. RBO_relaxed.owl GO:1904179 biolink:NamedThing positive regulation of adipose tissue development Any process that activates or increases the frequency, rate or extent of adipose tissue development. RBO_relaxed.owl GO:1904192 biolink:NamedThing regulation of cholangiocyte apoptotic process Any process that modulates the frequency, rate or extent of cholangiocyte apoptotic process. RBO_relaxed.owl GO:1904193 biolink:NamedThing negative regulation of cholangiocyte apoptotic process Any process that stops, prevents or reduces the frequency, rate or extent of cholangiocyte apoptotic process. RBO_relaxed.owl GO:1904194 biolink:NamedThing positive regulation of cholangiocyte apoptotic process Any process that activates or increases the frequency, rate or extent of cholangiocyte apoptotic process. RBO_relaxed.owl GO:1904204 biolink:NamedThing regulation of skeletal muscle hypertrophy Any process that modulates the frequency, rate or extent of skeletal muscle hypertrophy. RBO_relaxed.owl GO:1904205 biolink:NamedThing negative regulation of skeletal muscle hypertrophy Any process that stops, prevents or reduces the frequency, rate or extent of skeletal muscle hypertrophy. RBO_relaxed.owl GO:1904206 biolink:NamedThing positive regulation of skeletal muscle hypertrophy Any process that activates or increases the frequency, rate or extent of skeletal muscle hypertrophy. RBO_relaxed.owl GO:1904251 biolink:NamedThing regulation of bile acid metabolic process Any process that modulates the frequency, rate or extent of bile acid metabolic process. RBO_relaxed.owl GO:1904252 biolink:NamedThing negative regulation of bile acid metabolic process Any process that stops, prevents or reduces the frequency, rate or extent of bile acid metabolic process. RBO_relaxed.owl GO:1904253 biolink:NamedThing positive regulation of bile acid metabolic process Any process that activates or increases the frequency, rate or extent of bile acid metabolic process. RBO_relaxed.owl GO:1904304 biolink:NamedThing regulation of gastro-intestinal system smooth muscle contraction Any process that modulates the frequency, rate or extent of gastro-intestinal system smooth muscle contraction. RBO_relaxed.owl GO:1904305 biolink:NamedThing negative regulation of gastro-intestinal system smooth muscle contraction Any process that stops, prevents or reduces the frequency, rate or extent of gastro-intestinal system smooth muscle contraction. RBO_relaxed.owl GO:1904306 biolink:NamedThing positive regulation of gastro-intestinal system smooth muscle contraction Any process that activates or increases the frequency, rate or extent of gastro-intestinal system smooth muscle contraction. RBO_relaxed.owl GO:1904341 biolink:NamedThing regulation of colon smooth muscle contraction Any process that modulates the frequency, rate or extent of colon smooth muscle contraction. RBO_relaxed.owl GO:1904342 biolink:NamedThing negative regulation of colon smooth muscle contraction Any process that stops, prevents or reduces the frequency, rate or extent of colon smooth muscle contraction. RBO_relaxed.owl GO:1904343 biolink:NamedThing positive regulation of colon smooth muscle contraction Any process that activates or increases the frequency, rate or extent of colon smooth muscle contraction. RBO_relaxed.owl GO:1904344 biolink:NamedThing regulation of gastric mucosal blood circulation Any process that modulates the frequency, rate or extent of gastric mucosal blood circulation. RBO_relaxed.owl GO:1904345 biolink:NamedThing negative regulation of gastric mucosal blood circulation Any process that stops, prevents or reduces the frequency, rate or extent of gastric mucosal blood circulation. RBO_relaxed.owl GO:1904346 biolink:NamedThing positive regulation of gastric mucosal blood circulation Any process that activates or increases the frequency, rate or extent of gastric mucosal blood circulation. RBO_relaxed.owl GO:1904347 biolink:NamedThing regulation of small intestine smooth muscle contraction Any process that modulates the frequency, rate or extent of small intestine smooth muscle contraction. RBO_relaxed.owl GO:1904348 biolink:NamedThing negative regulation of small intestine smooth muscle contraction Any process that stops, prevents or reduces the frequency, rate or extent of small intestine smooth muscle contraction. RBO_relaxed.owl GO:1904349 biolink:NamedThing positive regulation of small intestine smooth muscle contraction Any process that activates or increases the frequency, rate or extent of small intestine smooth muscle contraction. RBO_relaxed.owl GO:1904350 biolink:NamedThing regulation of protein catabolic process in the vacuole Any process that modulates the frequency, rate or extent of protein catabolic process in the vacuole. RBO_relaxed.owl GO:1904351 biolink:NamedThing negative regulation of protein catabolic process in the vacuole Any process that stops, prevents or reduces the frequency, rate or extent of protein catabolic process in the vacuole. RBO_relaxed.owl GO:1904352 biolink:NamedThing positive regulation of protein catabolic process in the vacuole Any process that activates or increases the frequency, rate or extent of protein catabolic process in the vacuole. RBO_relaxed.owl GO:1904375 biolink:NamedThing regulation of protein localization to cell periphery Any process that modulates the frequency, rate or extent of protein localization to cell periphery. RBO_relaxed.owl GO:1904376 biolink:NamedThing negative regulation of protein localization to cell periphery Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to cell periphery. RBO_relaxed.owl GO:1904377 biolink:NamedThing positive regulation of protein localization to cell periphery Any process that activates or increases the frequency, rate or extent of protein localization to cell periphery. RBO_relaxed.owl GO:1904396 biolink:NamedThing regulation of neuromuscular junction development Any process that modulates the frequency, rate or extent of neuromuscular junction development. RBO_relaxed.owl GO:1904397 biolink:NamedThing negative regulation of neuromuscular junction development Any process that stops, prevents or reduces the frequency, rate or extent of neuromuscular junction development. RBO_relaxed.owl GO:1904398 biolink:NamedThing positive regulation of neuromuscular junction development Any process that activates or increases the frequency, rate or extent of neuromuscular junction development. RBO_relaxed.owl GO:1904409 biolink:NamedThing regulation of secretory granule organization Any process that modulates the frequency, rate or extent of secretory granule organization. RBO_relaxed.owl GO:1904410 biolink:NamedThing negative regulation of secretory granule organization Any process that stops, prevents or reduces the frequency, rate or extent of secretory granule organization. RBO_relaxed.owl GO:1904411 biolink:NamedThing positive regulation of secretory granule organization Any process that activates or increases the frequency, rate or extent of secretory granule organization. RBO_relaxed.owl GO:1904412 biolink:NamedThing regulation of cardiac ventricle development Any process that modulates the frequency, rate or extent of cardiac ventricle development. RBO_relaxed.owl GO:1904413 biolink:NamedThing negative regulation of cardiac ventricle development Any process that stops, prevents or reduces the frequency, rate or extent of cardiac ventricle development. RBO_relaxed.owl GO:1904414 biolink:NamedThing positive regulation of cardiac ventricle development Any process that activates or increases the frequency, rate or extent of cardiac ventricle development. RBO_relaxed.owl GO:1904456 biolink:NamedThing negative regulation of neuronal action potential Any process that stops, prevents or reduces the frequency, rate or extent of neuronal action potential. RBO_relaxed.owl GO:1904457 biolink:NamedThing positive regulation of neuronal action potential Any process that activates or increases the frequency, rate or extent of neuronal action potential. RBO_relaxed.owl GO:1904649 biolink:NamedThing regulation of fat cell apoptotic process Any process that modulates the frequency, rate or extent of fat cell apoptotic process. RBO_relaxed.owl GO:1904650 biolink:NamedThing negative regulation of fat cell apoptotic process Any process that stops, prevents or reduces the frequency, rate or extent of fat cell apoptotic process. RBO_relaxed.owl GO:1904651 biolink:NamedThing positive regulation of fat cell apoptotic process Any process that activates or increases the frequency, rate or extent of fat cell apoptotic process. RBO_relaxed.owl GO:1904675 biolink:NamedThing regulation of somatic stem cell division Any process that modulates the frequency, rate or extent of somatic stem cell division. RBO_relaxed.owl GO:1904676 biolink:NamedThing negative regulation of somatic stem cell division Any process that stops, prevents or reduces the frequency, rate or extent of somatic stem cell division. RBO_relaxed.owl GO:1904677 biolink:NamedThing positive regulation of somatic stem cell division Any process that activates or increases the frequency, rate or extent of somatic stem cell division. RBO_relaxed.owl GO:1904691 biolink:NamedThing negative regulation of type B pancreatic cell proliferation Any process that stops, prevents or reduces the frequency, rate or extent of type B pancreatic cell proliferation. RBO_relaxed.owl GO:1904692 biolink:NamedThing positive regulation of type B pancreatic cell proliferation Any process that activates or increases the frequency, rate or extent of type B pancreatic cell proliferation. RBO_relaxed.owl GO:1904697 biolink:NamedThing regulation of acinar cell proliferation Any process that modulates the frequency, rate or extent of acinar cell proliferation. RBO_relaxed.owl GO:1904698 biolink:NamedThing negative regulation of acinar cell proliferation Any process that stops, prevents or reduces the frequency, rate or extent of acinar cell proliferation. RBO_relaxed.owl GO:1904699 biolink:NamedThing positive regulation of acinar cell proliferation Any process that activates or increases the frequency, rate or extent of acinar cell proliferation. RBO_relaxed.owl GO:1904705 biolink:NamedThing regulation of vascular associated smooth muscle cell proliferation Any process that modulates the frequency, rate or extent of vascular smooth muscle cell proliferation. RBO_relaxed.owl GO:1904706 biolink:NamedThing negative regulation of vascular associated smooth muscle cell proliferation Any process that stops, prevents or reduces the frequency, rate or extent of vascular smooth muscle cell proliferation. RBO_relaxed.owl GO:1904707 biolink:NamedThing positive regulation of vascular associated smooth muscle cell proliferation Any process that activates or increases the frequency, rate or extent of vascular smooth muscle cell proliferation. RBO_relaxed.owl GO:1904746 biolink:NamedThing negative regulation of apoptotic process involved in development Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic process involved in development. RBO_relaxed.owl GO:1904747 biolink:NamedThing positive regulation of apoptotic process involved in development Any process that activates or increases the frequency, rate or extent of apoptotic process involved in development. RBO_relaxed.owl GO:1904748 biolink:NamedThing regulation of apoptotic process involved in development Any process that modulates the frequency, rate or extent of apoptotic process involved in development. RBO_relaxed.owl GO:1904749 biolink:NamedThing regulation of protein localization to nucleolus Any process that modulates the frequency, rate or extent of protein localization to nucleolus. RBO_relaxed.owl GO:1904750 biolink:NamedThing negative regulation of protein localization to nucleolus Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to nucleolus. RBO_relaxed.owl GO:1904751 biolink:NamedThing positive regulation of protein localization to nucleolus Any process that activates or increases the frequency, rate or extent of protein localization to nucleolus. RBO_relaxed.owl GO:1904776 biolink:NamedThing regulation of protein localization to cell cortex Any process that modulates the frequency, rate or extent of protein localization to cell cortex. RBO_relaxed.owl GO:1904777 biolink:NamedThing negative regulation of protein localization to cell cortex Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to cell cortex. RBO_relaxed.owl GO:1904778 biolink:NamedThing positive regulation of protein localization to cell cortex Any process that activates or increases the frequency, rate or extent of protein localization to cell cortex. RBO_relaxed.owl GO:1904829 biolink:NamedThing regulation of aortic smooth muscle cell differentiation Any process that modulates the frequency, rate or extent of aortic smooth muscle cell differentiation. RBO_relaxed.owl GO:1904830 biolink:NamedThing negative regulation of aortic smooth muscle cell differentiation Any process that stops, prevents or reduces the frequency, rate or extent of aortic smooth muscle cell differentiation. RBO_relaxed.owl GO:1904831 biolink:NamedThing positive regulation of aortic smooth muscle cell differentiation Any process that activates or increases the frequency, rate or extent of aortic smooth muscle cell differentiation. RBO_relaxed.owl GO:1904933 biolink:NamedThing regulation of cell proliferation in midbrain Any process that modulates the frequency, rate or extent of cell proliferation in midbrain. RBO_relaxed.owl GO:1904934 biolink:NamedThing negative regulation of cell proliferation in midbrain Any process that stops, prevents or reduces the frequency, rate or extent of cell proliferation in midbrain. RBO_relaxed.owl GO:1904935 biolink:NamedThing positive regulation of cell proliferation in midbrain Any process that activates or increases the frequency, rate or extent of cell proliferation in midbrain. RBO_relaxed.owl GO:1904942 biolink:NamedThing regulation of cardiac ventricle formation Any process that modulates the frequency, rate or extent of cardiac ventricle formation. RBO_relaxed.owl GO:1904943 biolink:NamedThing negative regulation of cardiac ventricle formation Any process that stops, prevents or reduces the frequency, rate or extent of cardiac ventricle formation. RBO_relaxed.owl GO:1904944 biolink:NamedThing positive regulation of cardiac ventricle formation Any process that activates or increases the frequency, rate or extent of cardiac ventricle formation. RBO_relaxed.owl GO:1904950 biolink:NamedThing negative regulation of establishment of protein localization Any process that stops, prevents or reduces the frequency, rate or extent of establishment of protein localization. RBO_relaxed.owl GO:1904951 biolink:NamedThing positive regulation of establishment of protein localization Any process that activates or increases the frequency, rate or extent of establishment of protein localization. RBO_relaxed.owl GO:1905063 biolink:NamedThing regulation of vascular associated smooth muscle cell differentiation Any process that modulates the frequency, rate or extent of vascular smooth muscle cell differentiation. RBO_relaxed.owl GO:1905064 biolink:NamedThing negative regulation of vascular associated smooth muscle cell differentiation Any process that stops, prevents or reduces the frequency, rate or extent of vascular smooth muscle cell differentiation. RBO_relaxed.owl GO:1905065 biolink:NamedThing positive regulation of vascular associated smooth muscle cell differentiation Any process that activates or increases the frequency, rate or extent of vascular smooth muscle cell differentiation. RBO_relaxed.owl GO:1905126 biolink:NamedThing regulation of axo-dendritic protein transport Any process that modulates the frequency, rate or extent of axo-dendritic protein transport. RBO_relaxed.owl GO:1905127 biolink:NamedThing negative regulation of axo-dendritic protein transport Any process that stops, prevents or reduces the frequency, rate or extent of axo-dendritic protein transport. RBO_relaxed.owl GO:1905128 biolink:NamedThing positive regulation of axo-dendritic protein transport Any process that activates or increases the frequency, rate or extent of axo-dendritic protein transport. RBO_relaxed.owl GO:1905140 biolink:NamedThing regulation of apical ectodermal ridge formation Any process that modulates the frequency, rate or extent of apical ectodermal ridge formation. RBO_relaxed.owl GO:1905141 biolink:NamedThing negative regulation of apical ectodermal ridge formation Any process that stops, prevents or reduces the frequency, rate or extent of apical ectodermal ridge formation. RBO_relaxed.owl GO:1905142 biolink:NamedThing positive regulation of apical ectodermal ridge formation Any process that activates or increases the frequency, rate or extent of apical ectodermal ridge formation. RBO_relaxed.owl GO:1905147 biolink:NamedThing regulation of smooth muscle hypertrophy Any process that modulates the frequency, rate or extent of smooth muscle hypertrophy. RBO_relaxed.owl GO:1905148 biolink:NamedThing negative regulation of smooth muscle hypertrophy Any process that stops, prevents or reduces the frequency, rate or extent of smooth muscle hypertrophy. RBO_relaxed.owl GO:1905149 biolink:NamedThing positive regulation of smooth muscle hypertrophy Any process that activates or increases the frequency, rate or extent of smooth muscle hypertrophy. RBO_relaxed.owl GO:1905207 biolink:NamedThing regulation of cardiocyte differentiation Any process that modulates the frequency, rate or extent of cardiocyte differentiation. RBO_relaxed.owl GO:1905208 biolink:NamedThing negative regulation of cardiocyte differentiation Any process that stops, prevents or reduces the frequency, rate or extent of cardiocyte differentiation. RBO_relaxed.owl GO:1905209 biolink:NamedThing positive regulation of cardiocyte differentiation Any process that activates or increases the frequency, rate or extent of cardiocyte differentiation. RBO_relaxed.owl GO:1905213 biolink:NamedThing negative regulation of mitotic chromosome condensation Any process that stops, prevents or reduces the frequency, rate or extent of mitotic chromosome condensation. RBO_relaxed.owl GO:1905268 biolink:NamedThing negative regulation of chromatin organization Any process that stops, prevents or reduces the frequency, rate or extent of chromatin organization. RBO_relaxed.owl GO:1905269 biolink:NamedThing positive regulation of chromatin organization Any process that activates or increases the frequency, rate or extent of chromatin organization. RBO_relaxed.owl GO:1905276 biolink:NamedThing regulation of epithelial tube formation Any process that modulates the frequency, rate or extent of epithelial tube formation. RBO_relaxed.owl GO:1905277 biolink:NamedThing negative regulation of epithelial tube formation Any process that stops, prevents or reduces the frequency, rate or extent of epithelial tube formation. RBO_relaxed.owl GO:1905278 biolink:NamedThing positive regulation of epithelial tube formation Any process that activates or increases the frequency, rate or extent of epithelial tube formation. RBO_relaxed.owl GO:1905292 biolink:NamedThing regulation of neural crest cell differentiation Any process that modulates the frequency, rate or extent of neural crest cell differentiation. RBO_relaxed.owl GO:1905293 biolink:NamedThing negative regulation of neural crest cell differentiation Any process that stops, prevents or reduces the frequency, rate or extent of neural crest cell differentiation. RBO_relaxed.owl GO:1905294 biolink:NamedThing positive regulation of neural crest cell differentiation Any process that activates or increases the frequency, rate or extent of neural crest cell differentiation. RBO_relaxed.owl GO:1905298 biolink:NamedThing regulation of intestinal epithelial cell development Any process that modulates the frequency, rate or extent of intestinal epithelial cell development. RBO_relaxed.owl GO:1905299 biolink:NamedThing negative regulation of intestinal epithelial cell development Any process that stops, prevents or reduces the frequency, rate or extent of intestinal epithelial cell development. RBO_relaxed.owl GO:1905300 biolink:NamedThing positive regulation of intestinal epithelial cell development Any process that activates or increases the frequency, rate or extent of intestinal epithelial cell development. RBO_relaxed.owl GO:1905304 biolink:NamedThing regulation of cardiac myofibril assembly Any process that modulates the frequency, rate or extent of cardiac myofibril assembly. RBO_relaxed.owl GO:1905305 biolink:NamedThing negative regulation of cardiac myofibril assembly Any process that stops, prevents or reduces the frequency, rate or extent of cardiac myofibril assembly. RBO_relaxed.owl GO:1905306 biolink:NamedThing positive regulation of cardiac myofibril assembly Any process that activates or increases the frequency, rate or extent of cardiac myofibril assembly. RBO_relaxed.owl GO:1905330 biolink:NamedThing regulation of morphogenesis of an epithelium Any process that modulates the frequency, rate or extent of morphogenesis of an epithelium. RBO_relaxed.owl GO:1905331 biolink:NamedThing negative regulation of morphogenesis of an epithelium Any process that stops, prevents or reduces the frequency, rate or extent of morphogenesis of an epithelium. RBO_relaxed.owl GO:1905332 biolink:NamedThing positive regulation of morphogenesis of an epithelium Any process that activates or increases the frequency, rate or extent of morphogenesis of an epithelium. RBO_relaxed.owl GO:1905384 biolink:NamedThing regulation of protein localization to presynapse Any process that modulates the frequency, rate or extent of protein localization to presynapse. RBO_relaxed.owl GO:1905385 biolink:NamedThing negative regulation of protein localization to presynapse Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to presynapse. RBO_relaxed.owl GO:1905386 biolink:NamedThing positive regulation of protein localization to presynapse Any process that activates or increases the frequency, rate or extent of protein localization to presynapse. RBO_relaxed.owl GO:1905432 biolink:NamedThing regulation of retrograde trans-synaptic signaling by neuropeptide Any process that modulates the frequency, rate or extent of retrograde trans-synaptic signaling by neuropeptide. RBO_relaxed.owl GO:1905433 biolink:NamedThing negative regulation of retrograde trans-synaptic signaling by neuropeptide Any process that stops, prevents or reduces the frequency, rate or extent of retrograde trans-synaptic signaling by neuropeptide. RBO_relaxed.owl GO:1905434 biolink:NamedThing positive regulation of retrograde trans-synaptic signaling by neuropeptide Any process that activates or increases the frequency, rate or extent of retrograde trans-synaptic signaling by neuropeptide. RBO_relaxed.owl GO:1905453 biolink:NamedThing regulation of myeloid progenitor cell differentiation Any process that modulates the frequency, rate or extent of myeloid progenitor cell differentiation. RBO_relaxed.owl GO:1905454 biolink:NamedThing negative regulation of myeloid progenitor cell differentiation Any process that stops, prevents or reduces the frequency, rate or extent of myeloid progenitor cell differentiation. RBO_relaxed.owl GO:1905455 biolink:NamedThing positive regulation of myeloid progenitor cell differentiation Any process that activates or increases the frequency, rate or extent of myeloid progenitor cell differentiation. RBO_relaxed.owl GO:1905459 biolink:NamedThing regulation of vascular associated smooth muscle cell apoptotic process Any process that modulates the frequency, rate or extent of vascular associated smooth muscle cell apoptotic process. RBO_relaxed.owl GO:1905460 biolink:NamedThing negative regulation of vascular associated smooth muscle cell apoptotic process Any process that stops, prevents or reduces the frequency, rate or extent of vascular associated smooth muscle cell apoptotic process. RBO_relaxed.owl GO:1905461 biolink:NamedThing positive regulation of vascular associated smooth muscle cell apoptotic process Any process that activates or increases the frequency, rate or extent of vascular associated smooth muscle cell apoptotic process. RBO_relaxed.owl GO:1905475 biolink:NamedThing regulation of protein localization to membrane Any process that modulates the frequency, rate or extent of protein localization to membrane. RBO_relaxed.owl GO:1905476 biolink:NamedThing negative regulation of protein localization to membrane Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to membrane. RBO_relaxed.owl GO:1905477 biolink:NamedThing positive regulation of protein localization to membrane Any process that activates or increases the frequency, rate or extent of protein localization to membrane. RBO_relaxed.owl GO:1905492 biolink:NamedThing positive regulation of branching morphogenesis of a nerve Any process that activates or increases the frequency, rate or extent of branching morphogenesis of a nerve. RBO_relaxed.owl GO:1905516 biolink:NamedThing positive regulation of fertilization Any process that activates or increases the frequency, rate or extent of fertilization. RBO_relaxed.owl GO:1905553 biolink:NamedThing regulation of blood vessel branching Any process that modulates the frequency, rate or extent of blood vessel branching. RBO_relaxed.owl GO:1905554 biolink:NamedThing negative regulation of vessel branching Any process that stops, prevents or reduces the frequency, rate or extent of blood vessel branching. RBO_relaxed.owl GO:1905555 biolink:NamedThing positive regulation of blood vessel branching Any process that activates or increases the frequency, rate or extent of blood vessel branching. RBO_relaxed.owl GO:1905557 biolink:NamedThing regulation of mitotic nuclear envelope disassembly Any process that modulates the frequency, rate or extent of mitotic nuclear envelope disassembly. RBO_relaxed.owl GO:1905558 biolink:NamedThing negative regulation of mitotic nuclear envelope disassembly Any process that stops, prevents or reduces the frequency, rate or extent of mitotic nuclear envelope disassembly. RBO_relaxed.owl GO:1905559 biolink:NamedThing positive regulation of mitotic nuclear envelope disassembly Any process that activates or increases the frequency, rate or extent of mitotic nuclear envelope disassembly. RBO_relaxed.owl GO:1905562 biolink:NamedThing regulation of vascular endothelial cell proliferation Any process that modulates the frequency, rate or extent of vascular endothelial cell proliferation. RBO_relaxed.owl GO:1905563 biolink:NamedThing negative regulation of vascular endothelial cell proliferation Any process that stops, prevents or reduces the frequency, rate or extent of vascular endothelial cell proliferation. RBO_relaxed.owl GO:1905564 biolink:NamedThing positive regulation of vascular endothelial cell proliferation Any process that activates or increases the frequency, rate or extent of vascular endothelial cell proliferation. RBO_relaxed.owl GO:1905606 biolink:NamedThing regulation of presynapse assembly Any process that modulates the frequency, rate or extent of presynapse assembly. RBO_relaxed.owl GO:1905607 biolink:NamedThing negative regulation of presynapse assembly Any process that stops, prevents or reduces the frequency, rate or extent of presynapse assembly. RBO_relaxed.owl GO:1905608 biolink:NamedThing positive regulation of presynapse assembly Any process that activates or increases the frequency, rate or extent of presynapse assembly. RBO_relaxed.owl GO:1905627 biolink:NamedThing regulation of serotonin biosynthetic process Any process that modulates the frequency, rate or extent of serotonin biosynthetic process. RBO_relaxed.owl GO:1905628 biolink:NamedThing negative regulation of serotonin biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of serotonin biosynthetic process. RBO_relaxed.owl GO:1905629 biolink:NamedThing positive regulation of serotonin biosynthetic process Any process that activates or increases the frequency, rate or extent of serotonin biosynthetic process. RBO_relaxed.owl GO:1905634 biolink:NamedThing regulation of protein localization to chromatin Any process that modulates the frequency, rate or extent of protein localization to chromatin. RBO_relaxed.owl GO:1905651 biolink:NamedThing regulation of artery morphogenesis Any process that modulates the frequency, rate or extent of artery morphogenesis. RBO_relaxed.owl GO:1905652 biolink:NamedThing negative regulation of artery morphogenesis Any process that stops, prevents or reduces the frequency, rate or extent of artery morphogenesis. RBO_relaxed.owl GO:1905653 biolink:NamedThing positive regulation of artery morphogenesis Any process that activates or increases the frequency, rate or extent of artery morphogenesis. RBO_relaxed.owl GO:1905770 biolink:NamedThing regulation of mesodermal cell differentiation Any process that modulates the frequency, rate or extent of mesodermal cell differentiation. RBO_relaxed.owl GO:1905771 biolink:NamedThing negative regulation of mesodermal cell differentiation Any process that stops, prevents or reduces the frequency, rate or extent of mesodermal cell differentiation. RBO_relaxed.owl GO:1905772 biolink:NamedThing positive regulation of mesodermal cell differentiation Any process that activates or increases the frequency, rate or extent of mesodermal cell differentiation. RBO_relaxed.owl GO:1905806 biolink:NamedThing regulation of synapse pruning Any process that modulates the frequency, rate or extent of synapse pruning. RBO_relaxed.owl GO:1905807 biolink:NamedThing negative regulation of synapse pruning Any process that stops, prevents or reduces the frequency, rate or extent of synapse pruning. RBO_relaxed.owl GO:1905808 biolink:NamedThing positive regulation of synapse pruning Any process that activates or increases the frequency, rate or extent of synapse pruning. RBO_relaxed.owl GO:1905809 biolink:NamedThing negative regulation of synapse organization Any process that stops, prevents or reduces the frequency, rate or extent of synapse organization. RBO_relaxed.owl GO:1905821 biolink:NamedThing positive regulation of chromosome condensation Any process that activates or increases the frequency, rate or extent of chromosome condensation. RBO_relaxed.owl GO:1905833 biolink:NamedThing negative regulation of microtubule nucleation Any process that stops, prevents or reduces the frequency, rate or extent of microtubule nucleation. RBO_relaxed.owl GO:1905843 biolink:NamedThing regulation of cellular response to gamma radiation Any process that modulates the frequency, rate or extent of cellular response to gamma radiation. RBO_relaxed.owl GO:1905844 biolink:NamedThing negative regulation of cellular response to gamma radiation Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to gamma radiation. RBO_relaxed.owl GO:1905845 biolink:NamedThing positive regulation of cellular response to gamma radiation Any process that activates or increases the frequency, rate or extent of cellular response to gamma radiation. RBO_relaxed.owl GO:1905871 biolink:NamedThing regulation of protein localization to cell leading edge Any process that modulates the frequency, rate or extent of protein localization to cell leading edge. RBO_relaxed.owl GO:1905872 biolink:NamedThing negative regulation of protein localization to cell leading edge Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to cell leading edge. RBO_relaxed.owl GO:1905873 biolink:NamedThing positive regulation of protein localization to cell leading edge Any process that activates or increases the frequency, rate or extent of protein localization to cell leading edge. RBO_relaxed.owl GO:1905879 biolink:NamedThing regulation of oogenesis Any process that modulates the frequency, rate or extent of oogenesis. RBO_relaxed.owl GO:1905880 biolink:NamedThing negative regulation of oogenesis Any process that stops, prevents or reduces the frequency, rate or extent of oogenesis. RBO_relaxed.owl GO:1905881 biolink:NamedThing positive regulation of oogenesis Any process that activates or increases the frequency, rate or extent of oogenesis. RBO_relaxed.owl GO:1905899 biolink:NamedThing regulation of smooth muscle tissue development Any process that modulates the frequency, rate or extent of smooth muscle tissue development. RBO_relaxed.owl GO:1905900 biolink:NamedThing negative regulation of smooth muscle tissue development Any process that stops, prevents or reduces the frequency, rate or extent of smooth muscle tissue development. RBO_relaxed.owl GO:1905901 biolink:NamedThing positive regulation of smooth muscle tissue development Any process that activates or increases the frequency, rate or extent of smooth muscle tissue development. RBO_relaxed.owl GO:1905902 biolink:NamedThing regulation of mesoderm formation Any process that modulates the frequency, rate or extent of mesoderm formation. RBO_relaxed.owl GO:1905903 biolink:NamedThing negative regulation of mesoderm formation Any process that stops, prevents or reduces the frequency, rate or extent of mesoderm formation. RBO_relaxed.owl GO:1905904 biolink:NamedThing positive regulation of mesoderm formation Any process that activates or increases the frequency, rate or extent of mesoderm formation. RBO_relaxed.owl GO:1905921 biolink:NamedThing regulation of acetylcholine biosynthetic process Any process that modulates the frequency, rate or extent of acetylcholine biosynthetic process. RBO_relaxed.owl GO:1905922 biolink:NamedThing negative regulation of acetylcholine biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of acetylcholine biosynthetic process. RBO_relaxed.owl GO:1905923 biolink:NamedThing positive regulation of acetylcholine biosynthetic process Any process that activates or increases the frequency, rate or extent of acetylcholine biosynthetic process. RBO_relaxed.owl GO:1905936 biolink:NamedThing regulation of germ cell proliferation Any process that modulates the frequency, rate or extent of germ cell proliferation. RBO_relaxed.owl GO:1905937 biolink:NamedThing negative regulation of germ cell proliferation Any process that stops, prevents or reduces the frequency, rate or extent of germ cell proliferation. RBO_relaxed.owl GO:1905938 biolink:NamedThing positive regulation of germ cell proliferation Any process that activates or increases the frequency, rate or extent of germ cell proliferation. RBO_relaxed.owl GO:1905939 biolink:NamedThing regulation of gonad development Any process that modulates the frequency, rate or extent of gonad development. RBO_relaxed.owl GO:1905940 biolink:NamedThing negative regulation of gonad development Any process that stops, prevents or reduces the frequency, rate or extent of gonad development. RBO_relaxed.owl GO:1905941 biolink:NamedThing positive regulation of gonad development Any process that activates or increases the frequency, rate or extent of gonad development. RBO_relaxed.owl GO:1905952 biolink:NamedThing regulation of lipid localization Any process that modulates the frequency, rate or extent of lipid localization. RBO_relaxed.owl GO:1905953 biolink:NamedThing negative regulation of lipid localization Any process that stops, prevents or reduces the frequency, rate or extent of lipid localization. RBO_relaxed.owl GO:1905954 biolink:NamedThing positive regulation of lipid localization Any process that activates or increases the frequency, rate or extent of lipid localization. RBO_relaxed.owl GO:1905955 biolink:NamedThing negative regulation of endothelial tube morphogenesis Any process that stops, prevents or reduces the frequency, rate or extent of endothelial tube morphogenesis. RBO_relaxed.owl GO:1905956 biolink:NamedThing positive regulation of endothelial tube morphogenesis Any process that activates or increases the frequency, rate or extent of endothelial tube morphogenesis. RBO_relaxed.owl GO:2000026 biolink:NamedThing regulation of multicellular organismal development Any process that modulates the frequency, rate or extent of multicellular organismal development. RBO_relaxed.owl GO:2000027 biolink:NamedThing regulation of animal organ morphogenesis Any process that modulates the frequency, rate or extent of animal organ morphogenesis. RBO_relaxed.owl GO:2000035 biolink:NamedThing regulation of stem cell division Any process that modulates the frequency, rate or extent of stem cell division. RBO_relaxed.owl GO:2000074 biolink:NamedThing regulation of type B pancreatic cell development Any process that modulates the frequency, rate or extent of pancreatic B cell development. RBO_relaxed.owl GO:2000077 biolink:NamedThing negative regulation of type B pancreatic cell development Any process that stops, prevents, or reduces the frequency, rate or extent of pancreatic B cell development. RBO_relaxed.owl GO:2000078 biolink:NamedThing positive regulation of type B pancreatic cell development Any process that activates or increases the frequency, rate or extent of pancreatic B cell development. RBO_relaxed.owl GO:2000106 biolink:NamedThing regulation of leukocyte apoptotic process Any process that modulates the frequency, rate or extent of leukocyte apoptotic process. RBO_relaxed.owl GO:2000107 biolink:NamedThing negative regulation of leukocyte apoptotic process Any process that stops, prevents, or reduces the frequency, rate or extent of leukocyte apoptotic process. RBO_relaxed.owl GO:2000108 biolink:NamedThing positive regulation of leukocyte apoptotic process Any process that activates or increases the frequency, rate or extent of leukocyte apoptotic process. RBO_relaxed.owl GO:2000114 biolink:NamedThing regulation of establishment of cell polarity Any process that modulates the frequency, rate or extent of establishment of cell polarity. RBO_relaxed.owl GO:2000136 biolink:NamedThing regulation of cell proliferation involved in heart morphogenesis Any process that modulates the frequency, rate or extent of cell proliferation involved in heart morphogenesis. RBO_relaxed.owl GO:2000137 biolink:NamedThing negative regulation of cell proliferation involved in heart morphogenesis Any process that stops, prevents, or reduces the frequency, rate or extent of cell proliferation involved in heart morphogenesis. RBO_relaxed.owl GO:2000138 biolink:NamedThing positive regulation of cell proliferation involved in heart morphogenesis Any process that activates or increases the frequency, rate or extent of cell proliferation involved in heart morphogenesis. RBO_relaxed.owl GO:2000145 biolink:NamedThing regulation of cell motility Any process that modulates the frequency, rate or extent of cell motility. RBO_relaxed.owl GO:2000146 biolink:NamedThing negative regulation of cell motility Any process that stops, prevents, or reduces the frequency, rate or extent of cell motility. RBO_relaxed.owl GO:2000147 biolink:NamedThing positive regulation of cell motility Any process that activates or increases the frequency, rate or extent of cell motility. RBO_relaxed.owl GO:2000172 biolink:NamedThing regulation of branching morphogenesis of a nerve Any process that modulates the frequency, rate or extent of branching morphogenesis of a nerve. RBO_relaxed.owl GO:2000173 biolink:NamedThing negative regulation of branching morphogenesis of a nerve Any process that stops, prevents, or reduces the frequency, rate or extent of branching morphogenesis of a nerve. RBO_relaxed.owl GO:2000177 biolink:NamedThing regulation of neural precursor cell proliferation Any process that modulates the frequency, rate or extent of neural precursor cell proliferation. RBO_relaxed.owl GO:2000178 biolink:NamedThing negative regulation of neural precursor cell proliferation Any process that stops, prevents, or reduces the frequency, rate or extent of neural precursor cell proliferation. RBO_relaxed.owl GO:2000179 biolink:NamedThing positive regulation of neural precursor cell proliferation Any process that activates or increases the frequency, rate or extent of neural precursor cell proliferation. RBO_relaxed.owl GO:2000181 biolink:NamedThing negative regulation of blood vessel morphogenesis Any process that stops, prevents, or reduces the frequency, rate or extent of blood vessel morphogenesis. RBO_relaxed.owl GO:2000185 biolink:NamedThing regulation of phosphate transmembrane transport Any process that modulates the frequency, rate or extent of phosphate transmembrane transport. RBO_relaxed.owl GO:2000186 biolink:NamedThing negative regulation of phosphate transmembrane transport Any process that stops, prevents, or reduces the frequency, rate or extent of phosphate transmembrane transport. RBO_relaxed.owl GO:2000187 biolink:NamedThing positive regulation of phosphate transmembrane transport Any process that activates or increases the frequency, rate or extent of phosphate transmembrane transport. RBO_relaxed.owl GO:2000194 biolink:NamedThing regulation of female gonad development Any process that modulates the frequency, rate or extent of female gonad development. RBO_relaxed.owl GO:2000195 biolink:NamedThing negative regulation of female gonad development Any process that stops, prevents, or reduces the frequency, rate or extent of female gonad development. RBO_relaxed.owl GO:2000196 biolink:NamedThing positive regulation of female gonad development Any process that activates or increases the frequency, rate or extent of female gonad development. RBO_relaxed.owl GO:2000226 biolink:NamedThing regulation of pancreatic A cell differentiation Any process that modulates the frequency, rate or extent of pancreatic A cell differentiation. RBO_relaxed.owl GO:2000227 biolink:NamedThing negative regulation of pancreatic A cell differentiation Any process that stops, prevents, or reduces the frequency, rate or extent of pancreatic A cell differentiation. RBO_relaxed.owl GO:2000228 biolink:NamedThing positive regulation of pancreatic A cell differentiation Any process that activates or increases the frequency, rate or extent of pancreatic A cell differentiation. RBO_relaxed.owl GO:2000241 biolink:NamedThing regulation of reproductive process Any process that modulates the frequency, rate or extent of reproductive process. RBO_relaxed.owl GO:2000242 biolink:NamedThing negative regulation of reproductive process Any process that stops, prevents, or reduces the frequency, rate or extent of reproductive process. RBO_relaxed.owl GO:2000243 biolink:NamedThing positive regulation of reproductive process Any process that activates or increases the frequency, rate or extent of reproductive process. RBO_relaxed.owl GO:2000248 biolink:NamedThing negative regulation of establishment or maintenance of neuroblast polarity Any process that stops, prevents, or reduces the frequency, rate or extent of establishment or maintenance of neuroblast polarity. RBO_relaxed.owl GO:2000269 biolink:NamedThing regulation of fibroblast apoptotic process Any process that modulates the frequency, rate or extent of fibroblast apoptotic process. RBO_relaxed.owl GO:2000270 biolink:NamedThing negative regulation of fibroblast apoptotic process Any process that stops, prevents or reduces the frequency, rate or extent of fibroblast apoptotic process. RBO_relaxed.owl GO:2000271 biolink:NamedThing positive regulation of fibroblast apoptotic process Any process that activates or increases the frequency, rate or extent of fibroblast apoptotic process. RBO_relaxed.owl GO:2000278 biolink:NamedThing regulation of DNA biosynthetic process Any process that modulates the frequency, rate or extent of DNA biosynthetic process. RBO_relaxed.owl GO:2000279 biolink:NamedThing negative regulation of DNA biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of DNA biosynthetic process. RBO_relaxed.owl GO:2000282 biolink:NamedThing regulation of cellular amino acid biosynthetic process Any process that modulates the frequency, rate or extent of cellular amino acid biosynthetic process. RBO_relaxed.owl GO:2000283 biolink:NamedThing negative regulation of amino acid biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of an amino acid biosynthetic process. RBO_relaxed.owl GO:2000284 biolink:NamedThing positive regulation of amino acid biosynthetic process Any process that activates or increases the frequency, rate or extent of cellular amino acid biosynthetic process. RBO_relaxed.owl GO:2000287 biolink:NamedThing positive regulation of myotome development Any process that activates or increases the frequency, rate or extent of myotome development. RBO_relaxed.owl GO:2000288 biolink:NamedThing positive regulation of myoblast proliferation Any process that activates or increases the frequency, rate or extent of myoblast proliferation. RBO_relaxed.owl GO:2000290 biolink:NamedThing regulation of myotome development Any process that modulates the frequency, rate or extent of myotome development. RBO_relaxed.owl GO:2000291 biolink:NamedThing regulation of myoblast proliferation Any process that modulates the frequency, rate or extent of myoblast proliferation. RBO_relaxed.owl GO:2000292 biolink:NamedThing regulation of defecation Any process that modulates the frequency, rate or extent of defecation. RBO_relaxed.owl GO:2000293 biolink:NamedThing negative regulation of defecation Any process that stops, prevents or reduces the frequency, rate or extent of defecation. RBO_relaxed.owl GO:2000294 biolink:NamedThing positive regulation of defecation Any process that activates or increases the frequency, rate or extent of defecation. RBO_relaxed.owl GO:2000351 biolink:NamedThing regulation of endothelial cell apoptotic process Any process that modulates the frequency, rate or extent of endothelial cell apoptotic process. RBO_relaxed.owl GO:2000352 biolink:NamedThing negative regulation of endothelial cell apoptotic process Any process that stops, prevents or reduces the frequency, rate or extent of endothelial cell apoptotic process. RBO_relaxed.owl GO:2000353 biolink:NamedThing positive regulation of endothelial cell apoptotic process Any process that activates or increases the frequency, rate or extent of endothelial cell apoptotic process. RBO_relaxed.owl GO:2000374 biolink:NamedThing regulation of oxygen metabolic process Any process that modulates the frequency, rate or extent of oxygen metabolic process. RBO_relaxed.owl GO:2000375 biolink:NamedThing negative regulation of oxygen metabolic process Any process that stops, prevents or reduces the frequency, rate or extent of oxygen metabolic process. RBO_relaxed.owl GO:2000376 biolink:NamedThing positive regulation of oxygen metabolic process Any process that activates or increases the frequency, rate or extent of oxygen metabolic process. RBO_relaxed.owl GO:2000380 biolink:NamedThing regulation of mesoderm development Any process that modulates the frequency, rate or extent of mesoderm development. RBO_relaxed.owl GO:2000381 biolink:NamedThing negative regulation of mesoderm development Any process that stops, prevents or reduces the frequency, rate or extent of mesoderm development. RBO_relaxed.owl GO:2000382 biolink:NamedThing positive regulation of mesoderm development Any process that activates or increases the frequency, rate or extent of mesoderm development. RBO_relaxed.owl GO:2000383 biolink:NamedThing regulation of ectoderm development Any process that modulates the frequency, rate or extent of ectoderm development. RBO_relaxed.owl GO:2000384 biolink:NamedThing negative regulation of ectoderm development Any process that stops, prevents or reduces the frequency, rate or extent of ectoderm development. RBO_relaxed.owl GO:2000385 biolink:NamedThing positive regulation of ectoderm development Any process that activates or increases the frequency, rate or extent of ectoderm development. RBO_relaxed.owl GO:2000495 biolink:NamedThing regulation of cell proliferation involved in compound eye morphogenesis Any process that modulates the frequency, rate or extent of cell proliferation involved in compound eye morphogenesis. RBO_relaxed.owl GO:2000496 biolink:NamedThing negative regulation of cell proliferation involved in compound eye morphogenesis Any process that stops, prevents or reduces the frequency, rate or extent of cell proliferation involved in compound eye morphogenesis. RBO_relaxed.owl GO:2000497 biolink:NamedThing positive regulation of cell proliferation involved in compound eye morphogenesis Any process that activates or increases the frequency, rate or extent of cell proliferation involved in compound eye morphogenesis. RBO_relaxed.owl GO:2000542 biolink:NamedThing negative regulation of gastrulation Any process that stops, prevents or reduces the frequency, rate or extent of gastrulation. RBO_relaxed.owl GO:2000543 biolink:NamedThing positive regulation of gastrulation Any process that activates or increases the frequency, rate or extent of gastrulation. RBO_relaxed.owl GO:2000573 biolink:NamedThing positive regulation of DNA biosynthetic process Any process that activates or increases the frequency, rate or extent of DNA biosynthetic process. RBO_relaxed.owl GO:2000647 biolink:NamedThing negative regulation of stem cell proliferation Any process that stops, prevents or reduces the frequency, rate or extent of stem cell proliferation. RBO_relaxed.owl GO:2000648 biolink:NamedThing positive regulation of stem cell proliferation Any process that activates or increases the frequency, rate or extent of stem cell proliferation. RBO_relaxed.owl GO:2000649 biolink:NamedThing regulation of sodium ion transmembrane transporter activity Any process that modulates the frequency, rate or extent of sodium ion transmembrane transporter activity. RBO_relaxed.owl GO:2000650 biolink:NamedThing negative regulation of sodium ion transmembrane transporter activity Any process that stops, prevents or reduces the frequency, rate or extent of sodium ion transmembrane transporter activity. RBO_relaxed.owl GO:2000651 biolink:NamedThing positive regulation of sodium ion transmembrane transporter activity Any process that activates or increases the frequency, rate or extent of sodium ion transmembrane transporter activity. RBO_relaxed.owl GO:2000671 biolink:NamedThing regulation of motor neuron apoptotic process Any process that modulates the frequency, rate or extent of motor neuron apoptotic process. RBO_relaxed.owl GO:2000672 biolink:NamedThing negative regulation of motor neuron apoptotic process Any process that stops, prevents or reduces the frequency, rate or extent of motor neuron apoptotic process. RBO_relaxed.owl GO:2000673 biolink:NamedThing positive regulation of motor neuron apoptotic process Any process that activates or increases the frequency, rate or extent of motor neuron apoptotic process. RBO_relaxed.owl GO:2000674 biolink:NamedThing regulation of type B pancreatic cell apoptotic process Any process that modulates the frequency, rate or extent of type B pancreatic cell apoptotic process. RBO_relaxed.owl GO:2000675 biolink:NamedThing negative regulation of type B pancreatic cell apoptotic process Any process that stops, prevents or reduces the frequency, rate or extent of type B pancreatic cell apoptotic process. RBO_relaxed.owl GO:2000676 biolink:NamedThing positive regulation of type B pancreatic cell apoptotic process Any process that activates or increases the frequency, rate or extent of type B pancreatic cell apoptotic process. RBO_relaxed.owl GO:2000683 biolink:NamedThing regulation of cellular response to X-ray Any process that modulates the frequency, rate or extent of cellular response to X-ray. RBO_relaxed.owl GO:2000684 biolink:NamedThing negative regulation of cellular response to X-ray Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to X-ray. RBO_relaxed.owl GO:2000685 biolink:NamedThing positive regulation of cellular response to X-ray Any process that activates or increases the frequency, rate or extent of cellular response to X-ray. RBO_relaxed.owl GO:2000690 biolink:NamedThing regulation of cardiac muscle cell myoblast differentiation Any process that modulates the frequency, rate or extent of cardiac muscle cell myoblast differentiation. RBO_relaxed.owl GO:2000691 biolink:NamedThing negative regulation of cardiac muscle cell myoblast differentiation Any process that stops, prevents or reduces the frequency, rate or extent of cardiac muscle cell myoblast differentiation. RBO_relaxed.owl GO:2000700 biolink:NamedThing positive regulation of cardiac muscle cell myoblast differentiation Any process that activates or increases the frequency, rate or extent of cardiac muscle cell myoblast differentiation. RBO_relaxed.owl GO:2000725 biolink:NamedThing regulation of cardiac muscle cell differentiation Any process that modulates the frequency, rate or extent of cardiac muscle cell differentiation. RBO_relaxed.owl GO:2000726 biolink:NamedThing negative regulation of cardiac muscle cell differentiation Any process that stops, prevents or reduces the frequency, rate or extent of cardiac muscle cell differentiation. RBO_relaxed.owl GO:2000727 biolink:NamedThing positive regulation of cardiac muscle cell differentiation Any process that activates or increases the frequency, rate or extent of cardiac muscle cell differentiation. RBO_relaxed.owl GO:2000736 biolink:NamedThing regulation of stem cell differentiation Any process that modulates the frequency, rate or extent of stem cell differentiation. RBO_relaxed.owl GO:2000737 biolink:NamedThing negative regulation of stem cell differentiation Any process that stops, prevents or reduces the frequency, rate or extent of stem cell differentiation. RBO_relaxed.owl GO:2000738 biolink:NamedThing positive regulation of stem cell differentiation Any process that activates or increases the frequency, rate or extent of stem cell differentiation. RBO_relaxed.owl GO:2000790 biolink:NamedThing regulation of mesenchymal cell proliferation involved in lung development Any process that modulates the frequency, rate or extent of mesenchymal cell proliferation involved in lung development. RBO_relaxed.owl GO:2000791 biolink:NamedThing negative regulation of mesenchymal cell proliferation involved in lung development Any process that stops, prevents or reduces the frequency, rate or extent of mesenchymal cell proliferation involved in lung development. RBO_relaxed.owl GO:2000792 biolink:NamedThing positive regulation of mesenchymal cell proliferation involved in lung development Any process that activates or increases the frequency, rate or extent of mesenchymal cell proliferation involved in lung development. RBO_relaxed.owl GO:2000794 biolink:NamedThing regulation of epithelial cell proliferation involved in lung morphogenesis Any process that modulates the frequency, rate or extent of epithelial cell proliferation involved in lung morphogenesis. RBO_relaxed.owl GO:2000795 biolink:NamedThing negative regulation of epithelial cell proliferation involved in lung morphogenesis Any process that stops, prevents or reduces the frequency, rate or extent of epithelial cell proliferation involved in lung morphogenesis. RBO_relaxed.owl GO:2000818 biolink:NamedThing negative regulation of myoblast proliferation Any process that stops, prevents or reduces the frequency, rate or extent of myoblast proliferation. RBO_relaxed.owl GO:2000826 biolink:NamedThing regulation of heart morphogenesis Any process that modulates the frequency, rate or extent of heart morphogenesis. RBO_relaxed.owl GO:2000831 biolink:NamedThing regulation of steroid hormone secretion Any process that modulates the frequency, rate or extent of steroid hormone secretion. RBO_relaxed.owl GO:2000832 biolink:NamedThing negative regulation of steroid hormone secretion Any process that stops, prevents or reduces the frequency, rate or extent of steroid hormone secretion. RBO_relaxed.owl GO:2000833 biolink:NamedThing positive regulation of steroid hormone secretion Any process that activates or increases the frequency, rate or extent of steroid hormone secretion. RBO_relaxed.owl GO:2000834 biolink:NamedThing regulation of androgen secretion Any process that modulates the frequency, rate or extent of androgen secretion. RBO_relaxed.owl GO:2000835 biolink:NamedThing negative regulation of androgen secretion Any process that stops, prevents or reduces the frequency, rate or extent of androgen secretion. RBO_relaxed.owl GO:2000836 biolink:NamedThing positive regulation of androgen secretion Any process that activates or increases the frequency, rate or extent of androgen secretion. RBO_relaxed.owl GO:2001014 biolink:NamedThing regulation of skeletal muscle cell differentiation Any process that modulates the frequency, rate or extent of skeletal muscle cell differentiation. RBO_relaxed.owl GO:2001015 biolink:NamedThing negative regulation of skeletal muscle cell differentiation Any process that stops, prevents or reduces the frequency, rate or extent of skeletal muscle cell differentiation. RBO_relaxed.owl GO:2001016 biolink:NamedThing positive regulation of skeletal muscle cell differentiation Any process that activates or increases the frequency, rate or extent of skeletal muscle cell differentiation. RBO_relaxed.owl GO:2001053 biolink:NamedThing regulation of mesenchymal cell apoptotic process Any process that modulates the frequency, rate or extent of mesenchymal cell apoptotic process. RBO_relaxed.owl GO:2001054 biolink:NamedThing negative regulation of mesenchymal cell apoptotic process Any process that stops, prevents or reduces the frequency, rate or extent of mesenchymal cell apoptotic process. RBO_relaxed.owl GO:2001055 biolink:NamedThing positive regulation of mesenchymal cell apoptotic process Any process that activates or increases the frequency, rate or extent of mesenchymal cell apoptotic process. RBO_relaxed.owl GO:2001141 biolink:NamedThing regulation of RNA biosynthetic process Any process that modulates the frequency, rate or extent of RNA biosynthetic process. RBO_relaxed.owl GO:2001212 biolink:NamedThing regulation of vasculogenesis Any process that modulates the frequency, rate or extent of vasculogenesis. RBO_relaxed.owl GO:2001213 biolink:NamedThing negative regulation of vasculogenesis Any process that stops, prevents or reduces the frequency, rate or extent of vasculogenesis. RBO_relaxed.owl GO:2001214 biolink:NamedThing positive regulation of vasculogenesis Any process that activates or increases the frequency, rate or extent of vasculogenesis. RBO_relaxed.owl GO:2001228 biolink:NamedThing regulation of response to gamma radiation Any process that modulates the frequency, rate or extent of response to gamma radiation. RBO_relaxed.owl GO:2001229 biolink:NamedThing negative regulation of response to gamma radiation Any process that stops, prevents or reduces the frequency, rate or extent of response to gamma radiation. RBO_relaxed.owl GO:2001230 biolink:NamedThing positive regulation of response to gamma radiation Any process that activates or increases the frequency, rate or extent of response to gamma radiation. RBO_relaxed.owl GO:2001233 biolink:NamedThing regulation of apoptotic signaling pathway Any process that modulates the frequency, rate or extent of apoptotic signaling pathway. RBO_relaxed.owl GO:2001234 biolink:NamedThing negative regulation of apoptotic signaling pathway Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic signaling pathway. RBO_relaxed.owl GO:2001235 biolink:NamedThing positive regulation of apoptotic signaling pathway Any process that activates or increases the frequency, rate or extent of apoptotic signaling pathway. RBO_relaxed.owl GO:2001251 biolink:NamedThing negative regulation of chromosome organization Any process that stops, prevents or reduces the frequency, rate or extent of chromosome organization. RBO_relaxed.owl GO:2001252 biolink:NamedThing positive regulation of chromosome organization Any process that activates or increases the frequency, rate or extent of chromosome organization. RBO_relaxed.owl GO:0001569 biolink:NamedThing branching involved in blood vessel morphogenesis The process of coordinated growth and sprouting of blood vessels giving rise to the organized vascular system. RBO_relaxed.owl GO:0048754 biolink:NamedThing branching morphogenesis of an epithelial tube The process in which the anatomical structures of branches in an epithelial tube are generated and organized. A tube is a long hollow cylinder. RBO_relaxed.owl GO:0060441 biolink:NamedThing epithelial tube branching involved in lung morphogenesis The process in which a highly ordered sequence of patterning events generates the branched epithelial tubes of the lung, consisting of reiterated combinations of bud outgrowth, elongation, and dichotomous subdivision of terminal units. RBO_relaxed.owl GO:0001570 biolink:NamedThing vasculogenesis The differentiation of endothelial cells from progenitor cells during blood vessel development, and the de novo formation of blood vessels and tubes. RBO_relaxed.owl GO:0030154 biolink:NamedThing cell differentiation The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state. RBO_relaxed.owl GO:0001751 biolink:NamedThing compound eye photoreceptor cell differentiation The process in which a relatively unspecialized cell acquires the specialized features of an eye photoreceptor cell. RBO_relaxed.owl GO:0001754 biolink:NamedThing eye photoreceptor cell differentiation The process in which a relatively unspecialized cell acquires the specialized features of a photoreceptor cell, as found in the eye, the primary visual organ of most organisms. RBO_relaxed.owl GO:0001826 biolink:NamedThing inner cell mass cell differentiation The process in which a relatively unspecialized cell acquires specialized features of an inner cell mass cell. RBO_relaxed.owl GO:0001829 biolink:NamedThing trophectodermal cell differentiation The process in which a relatively unspecialized cell acquires the specialized features of a trophectoderm cell. RBO_relaxed.owl GO:0001837 biolink:NamedThing epithelial to mesenchymal transition A transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. RBO_relaxed.owl GO:0002062 biolink:NamedThing chondrocyte differentiation The process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte. A chondrocyte is a polymorphic cell that forms cartilage. RBO_relaxed.owl GO:0002065 biolink:NamedThing columnar/cuboidal epithelial cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a columnar/cuboidal epithelial cell. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube. RBO_relaxed.owl GO:0002067 biolink:NamedThing glandular epithelial cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a glandular epithelial cell. A glandular epithelial cell is a columnar/cuboidal epithelial cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland. RBO_relaxed.owl GO:0002244 biolink:NamedThing hematopoietic progenitor cell differentiation The process in which precursor cell type acquires the specialized features of a hematopoietic progenitor cell, a class of cell types including myeloid progenitor cells and lymphoid progenitor cells. RBO_relaxed.owl GO:0002318 biolink:NamedThing myeloid progenitor cell differentiation The process in which a precursor cell type acquires the specialized features of a myeloid progenitor cell. Myeloid progenitor cells include progenitor cells for any of the myeloid lineages. RBO_relaxed.owl GO:0002521 biolink:NamedThing leukocyte differentiation The process in which a relatively unspecialized hemopoietic precursor cell acquires the specialized features of a leukocyte. A leukocyte is an achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue. RBO_relaxed.owl GO:0002573 biolink:NamedThing myeloid leukocyte differentiation The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte lineage. RBO_relaxed.owl GO:0003168 biolink:NamedThing Purkinje myocyte differentiation The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a Purkinje myocyte (also known as cardiac Purkinje fiber cell). These cells are specialized cardiomyocytes that receive signals from the bundle of His and innervate the ventricular cardiac muscle. RBO_relaxed.owl GO:0003292 biolink:NamedThing cardiac septum cell differentiation The process in which an endocardial cushion cell becomes a cell of a cardiac septum. RBO_relaxed.owl GO:0003309 biolink:NamedThing type B pancreatic cell differentiation The process in which relatively unspecialized cells acquire specialized structural and/or functional features of a type B pancreatic cell. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin. RBO_relaxed.owl GO:0003310 biolink:NamedThing pancreatic A cell differentiation The process in which relatively unspecialized cells acquire specialized structural and functional features of a pancreatic A cell. A pancreatic A cell is a cell in the pancreas that secretes glucagon. RBO_relaxed.owl GO:0003311 biolink:NamedThing pancreatic D cell differentiation The process in which relatively unspecialized cells acquire specialized structural and functional features that characterize a pancreatic delta cell. A delta cell is a cell of the pancreas that produces somatostatin. RBO_relaxed.owl GO:0003312 biolink:NamedThing pancreatic PP cell differentiation The process in which relatively unspecialized cells acquire specialized structural and functional features of a pancreatic polypeptide-producing cell. A pancreatic polypeptide-producing cell is a cell in the pancreas that produces pancreatic polypeptide. RBO_relaxed.owl GO:0003348 biolink:NamedThing cardiac endothelial cell differentiation The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cardiac endothelial cell. RBO_relaxed.owl GO:0003357 biolink:NamedThing noradrenergic neuron differentiation The process in which a relatively unspecialized cell acquires specialized features of an noradrenergic neuron, a neuron that secretes noradrenaline. RBO_relaxed.owl GO:0009913 biolink:NamedThing epidermal cell differentiation The process in which a relatively unspecialized cell acquires specialized features of an epidermal cell, any of the cells making up the epidermis. RBO_relaxed.owl GO:0010001 biolink:NamedThing glial cell differentiation The process in which a relatively unspecialized cell acquires the specialized features of a glial cell. RBO_relaxed.owl GO:0010002 biolink:NamedThing cardioblast differentiation The process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating. RBO_relaxed.owl GO:0010668 biolink:NamedThing ectodermal cell differentiation The process in which relatively unspecialized cells acquire specialized structural and/or functional features of an ectodermal cell. Differentiation includes the processes involved in commitment of a cell to a specific fate. RBO_relaxed.owl GO:0014016 biolink:NamedThing neuroblast differentiation The process in which a relatively unspecialized cell acquires specialized features of a neuroblast. There are at least four stages through which the pluripotent cells of epiblast or blastula become neuroblasts. RBO_relaxed.owl GO:0014033 biolink:NamedThing neural crest cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a neural crest cell. RBO_relaxed.owl GO:0014902 biolink:NamedThing myotube differentiation The process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotube differentiation starts with myoblast fusion and the appearance of specific cell markers (this is the cell development step). Then individual myotubes can fuse to form bigger myotubes and start to contract. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse. RBO_relaxed.owl GO:0021514 biolink:NamedThing ventral spinal cord interneuron differentiation The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of ventral spinal cord interneurons. Ventral spinal cord interneurons are cells located in the ventral portion of the spinal cord that transmit signals between sensory and motor neurons and are required for reflexive responses. Differentiation includes the processes involved in commitment of a cell to a specific fate. RBO_relaxed.owl GO:0021515 biolink:NamedThing cell differentiation in spinal cord The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the spinal cord. Differentiation includes the processes involved in commitment of a cell to a specific fate. RBO_relaxed.owl GO:0021522 biolink:NamedThing spinal cord motor neuron differentiation The process in which neuroepithelial cells in the ventral neural tube acquire specialized structural and/or functional features of motor neurons. Motor neurons innervate an effector (muscle or glandular) tissue and are responsible for transmission of motor impulses from the brain to the periphery. Differentiation includes the processes involved in commitment of a cell to a specific fate. RBO_relaxed.owl GO:0021523 biolink:NamedThing somatic motor neuron differentiation The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of somatic motor neurons. Somatic motor neurons innervate skeletal muscle targets and are responsible for transmission of motor impulses from the brain to the periphery. Differentiation includes the processes involved in commitment of a cell to a specific fate. RBO_relaxed.owl GO:0021533 biolink:NamedThing cell differentiation in hindbrain The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mature cells of the hindbrain. Differentiation includes the processes involved in commitment of a cell to a specific fate. RBO_relaxed.owl GO:0021953 biolink:NamedThing central nervous system neuron differentiation The process in which a relatively unspecialized cell acquires specialized features of a neuron whose cell body resides in the central nervous system. RBO_relaxed.owl GO:0022008 biolink:NamedThing neurogenesis Generation of cells within the nervous system. RBO_relaxed.owl GO:0030099 biolink:NamedThing myeloid cell differentiation The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte, megakaryocyte, thrombocyte, or erythrocyte lineages. RBO_relaxed.owl GO:0030182 biolink:NamedThing neuron differentiation The process in which a relatively unspecialized cell acquires specialized features of a neuron. RBO_relaxed.owl GO:0030218 biolink:NamedThing erythrocyte differentiation The process in which a myeloid precursor cell acquires specializes features of an erythrocyte. RBO_relaxed.owl GO:0030219 biolink:NamedThing megakaryocyte differentiation The process in which a myeloid precursor cell acquires specializes features of a megakaryocyte. RBO_relaxed.owl GO:0030855 biolink:NamedThing epithelial cell differentiation The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell, any of the cells making up an epithelium. RBO_relaxed.owl GO:0035051 biolink:NamedThing cardiocyte differentiation The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cell that will form part of the cardiac organ of an individual. RBO_relaxed.owl GO:0035645 biolink:NamedThing enteric smooth muscle cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a smooth muscle cell of the intestine. RBO_relaxed.owl GO:0035779 biolink:NamedThing angioblast cell differentiation The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of an angioblast cell. Angioblasts are one of the two products formed from hemangioblast cells (the other being pluripotent hemopoietic stem cells). RBO_relaxed.owl GO:0035883 biolink:NamedThing enteroendocrine cell differentiation The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of an enteroendocrine cell. Enteroendocrine cells are hormonally active epithelial cells in the gut that constitute the diffuse neuroendocrine system. RBO_relaxed.owl GO:0035886 biolink:NamedThing vascular associated smooth muscle cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a vascular smooth muscle cell. RBO_relaxed.owl GO:0035887 biolink:NamedThing aortic smooth muscle cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a smooth muscle cell surrounding the aorta. RBO_relaxed.owl GO:0035914 biolink:NamedThing skeletal muscle cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a skeletal muscle cell, a somatic cell located in skeletal muscle. RBO_relaxed.owl GO:0035987 biolink:NamedThing endodermal cell differentiation The process in which a relatively unspecialized cell acquires the specialized features of an endoderm cell, a cell of the inner of the three germ layers of the embryo. RBO_relaxed.owl GO:0042670 biolink:NamedThing retinal cone cell differentiation The process in which a relatively unspecialized cell acquires the specialized features of a retinal cone cell. RBO_relaxed.owl GO:0042692 biolink:NamedThing muscle cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a muscle cell. RBO_relaxed.owl GO:0043353 biolink:NamedThing enucleate erythrocyte differentiation The process in which a myeloid precursor cell acquires specialized features of an erythrocyte without a nucleus. An example of this process is found in Mus musculus. RBO_relaxed.owl GO:0043363 biolink:NamedThing nucleate erythrocyte differentiation The process in which a myeloid precursor cell acquires specializes features of an erythrocyte with a nucleus, as found in non-mammalian vertebrates such as birds. RBO_relaxed.owl GO:0045444 biolink:NamedThing fat cell differentiation The process in which a relatively unspecialized cell acquires specialized features of an adipocyte, an animal connective tissue cell specialized for the synthesis and storage of fat. RBO_relaxed.owl GO:0045445 biolink:NamedThing myoblast differentiation The process in which a relatively unspecialized cell acquires specialized features of a myoblast. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into striated muscle fibers. RBO_relaxed.owl GO:0045446 biolink:NamedThing endothelial cell differentiation The process in which a mesodermal, bone marrow or neural crest cell acquires specialized features of an endothelial cell, a thin flattened cell. A layer of such cells lines the inside surfaces of body cavities, blood vessels, and lymph vessels, making up the endothelium. RBO_relaxed.owl GO:0046530 biolink:NamedThing photoreceptor cell differentiation The specialization of organization of a photoreceptor, a cell that responds to incident electromagnetic radiation, particularly visible light. An example of this process is found in Drosophila melanogaster. RBO_relaxed.owl GO:0048333 biolink:NamedThing mesodermal cell differentiation The process in which a relatively unspecialized cell acquires the specialized features of a mesoderm cell. RBO_relaxed.owl GO:0048762 biolink:NamedThing mesenchymal cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a mesenchymal cell. A mesenchymal cell is a loosely associated cell that is part of the connective tissue in an organism. Mesenchymal cells give rise to more mature connective tissue cell types. RBO_relaxed.owl GO:0048863 biolink:NamedThing stem cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a stem cell. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells. RBO_relaxed.owl GO:0048934 biolink:NamedThing peripheral nervous system neuron differentiation The process in which a relatively unspecialized cell acquires specialized features of a neuron whose cell body resides in the peripheral nervous system. RBO_relaxed.owl GO:0050931 biolink:NamedThing pigment cell differentiation The process in which a relatively unspecialized cell acquires the specialized features of a pigmented cell, such as a melanocyte. RBO_relaxed.owl GO:0051145 biolink:NamedThing smooth muscle cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a smooth muscle cell; smooth muscle lacks transverse striations in its constituent fibers and are almost always involuntary. RBO_relaxed.owl GO:0051146 biolink:NamedThing striated muscle cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a striated muscle cell; striated muscle fibers are divided by transverse bands into striations, and cardiac and voluntary muscle are types of striated muscle. RBO_relaxed.owl GO:0055007 biolink:NamedThing cardiac muscle cell differentiation The process in which a cardiac muscle precursor cell acquires specialized features of a cardiac muscle cell. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. RBO_relaxed.owl GO:0060218 biolink:NamedThing hematopoietic stem cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a hematopoietic stem cell. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells. RBO_relaxed.owl GO:0060219 biolink:NamedThing camera-type eye photoreceptor cell differentiation The process in which a relatively unspecialized cell acquires the specialized features of a photoreceptor cell in a camera-type eye. RBO_relaxed.owl GO:0060221 biolink:NamedThing retinal rod cell differentiation The process in which a relatively unspecialized cell acquires the specialized features of a retinal rod cell. RBO_relaxed.owl GO:0060231 biolink:NamedThing mesenchymal to epithelial transition A transition where a mesenchymal cell establishes apical/basolateral polarity, forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell. RBO_relaxed.owl GO:0060379 biolink:NamedThing cardiac muscle cell myoblast differentiation The process in which a relatively unspecialized cell acquires specialized features of a cardiac myoblast. A cardiac myoblast is a precursor cell that has been committed to a cardiac muscle cell fate but retains the ability to divide and proliferate throughout life. RBO_relaxed.owl GO:0060479 biolink:NamedThing lung cell differentiation The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features of a mature cell found in the lung. Differentiation includes the processes involved in commitment of a cell to a specific fate. RBO_relaxed.owl GO:0060487 biolink:NamedThing lung epithelial cell differentiation The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell that contributes to the epithelium of the lung. RBO_relaxed.owl GO:0060563 biolink:NamedThing neuroepithelial cell differentiation The process in which epiblast cells acquire specialized features of neuroepithelial cells. RBO_relaxed.owl GO:0060575 biolink:NamedThing intestinal epithelial cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a columnar/cuboidal epithelial cell of the intestine. RBO_relaxed.owl GO:0060591 biolink:NamedThing chondroblast differentiation The process in which a mesenchymal cell, acquires specialized structural and/or functional features of a chondroblast. Differentiation includes the processes involved in commitment of a cell to a chondroblast fate. A chondroblast is a precursor cell to chondrocytes. RBO_relaxed.owl GO:0060837 biolink:NamedThing blood vessel endothelial cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a blood vessel endothelial cell, a thin flattened cell that lines the inside surfaces of blood vessels. RBO_relaxed.owl GO:0060842 biolink:NamedThing arterial endothelial cell differentiation The process in which a relatively unspecialized endothelial cell acquires specialized features of an arterial endothelial cell, a thin flattened cell that lines the inside surfaces of arteries. RBO_relaxed.owl GO:0060843 biolink:NamedThing venous endothelial cell differentiation The process in which a relatively unspecialized endothelial cell acquires specialized features of a venous endothelial cell, a thin flattened cell that lines the inside surfaces of veins. RBO_relaxed.owl GO:0060920 biolink:NamedThing cardiac pacemaker cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a pacemaker cell. Pacemaker cells are specialized cardiomyocytes that are responsible for regulating the timing of heart contractions. RBO_relaxed.owl GO:0060921 biolink:NamedThing sinoatrial node cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a sinoatrial (SA) node cell. SA node cells are pacemaker cells that are found in the sinoatrial node. RBO_relaxed.owl GO:0060922 biolink:NamedThing atrioventricular node cell differentiation The process in which a relatively unspecialized cell acquires specialized features of an atrioventricular (AV) node cell. AV node cells are pacemaker cells that are found in the atrioventricular node. RBO_relaxed.owl GO:0060932 biolink:NamedThing His-Purkinje system cell differentiation The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cell of the His-Purkinje system. These cells form the fibers regulate cardiac muscle contraction in the ventricles. RBO_relaxed.owl GO:0060935 biolink:NamedThing cardiac fibroblast cell differentiation The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cardiac fibroblast. A cardiac fibroblast is a connective tissue cell in the heart which secretes an extracellular matrix rich in collagen and other macromolecules. RBO_relaxed.owl GO:0060945 biolink:NamedThing cardiac neuron differentiation The process in which a relatively unspecialized cell acquires specialized features of a neuron of the heart. RBO_relaxed.owl GO:0060946 biolink:NamedThing cardiac blood vessel endothelial cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a blood vessel endothelial cell of the heart. Blood vessel endothelial cells are thin flattened cells that line the inside surfaces of blood vessels. RBO_relaxed.owl GO:0060950 biolink:NamedThing cardiac glial cell differentiation The process in which a relatively unspecialized cell acquires the specialized features of a glial cell of the heart. RBO_relaxed.owl GO:0060956 biolink:NamedThing endocardial cell differentiation The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of an endocardial cell. An endocardial cell is a specialized endothelial cell that makes up the endocardium portion of the heart. The endocardium is the innermost layer of tissue of the heart, and lines the heart chambers. RBO_relaxed.owl GO:0061017 biolink:NamedThing hepatoblast differentiation The process in which a relatively unspecialized cell acquires specialized features of a hepatoblast. A hepatoblast is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into hepatocytes and cholangiocytes. RBO_relaxed.owl GO:0061100 biolink:NamedThing lung neuroendocrine cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a neuroendocrine cell of the lung epithelium. RBO_relaxed.owl GO:0061101 biolink:NamedThing neuroendocrine cell differentiation The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a neuroendocrine cell. A neuroendocrine cell is a cell that receives input form a neuron which controls the secretion of an endocrine substance. RBO_relaxed.owl GO:0061102 biolink:NamedThing stomach neuroendocrine cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a neuroendocrine cell of the stomach epithelium. RBO_relaxed.owl GO:0061140 biolink:NamedThing lung secretory cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a lung secretory cell. A lung secretory cell is a specialized epithelial cell of the lung that contains large secretory granules in its apical part. RBO_relaxed.owl GO:0061141 biolink:NamedThing lung ciliated cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a lung ciliated cell. A lung ciliated cell is a specialized lung epithelial cell that contains cilia for moving substances released from lung secretory cells. RBO_relaxed.owl GO:0061453 biolink:NamedThing interstitial cell of Cajal differentiation The process in which a relatively unspecialized cell acquires specialized features of an interstitial cell of Cajal. An interstitial cell of Cajal is an intestinal neuroepithelial cell that serves as a pacemaker to trigger gut contraction. RBO_relaxed.owl GO:0070365 biolink:NamedThing hepatocyte differentiation The process in which a relatively unspecialized cell acquires the specialized features of a hepatocyte. A hepatocyte is specialized epithelial cell that is organized into interconnected plates called lobules, and is the main structural component of the liver. RBO_relaxed.owl GO:0090425 biolink:NamedThing acinar cell differentiation The epithelial cell differentiation process in which a relatively unspecialized cell acquires specialized features of an acinar cell, a secretory cell that is grouped together with other cells of the same type to form grape-shaped clusters known as acini. RBO_relaxed.owl GO:0098528 biolink:NamedThing skeletal muscle fiber differentiation The process in which a relatively unspecialized cell acquires specialized features of a skeletal muscle fiber cell. Skeletal muscle fiber differentiation starts with myoblast fusion and the appearance of specific cell markers (this is the cell development step). Then individual skeletal muscle fibers fuse to form bigger myotubes and start to contract. RBO_relaxed.owl GO:1903131 biolink:NamedThing mononuclear cell differentiation The process in which a relatively unspecialized cell acquires the specialized features of a mononuclear cell. RBO_relaxed.owl GO:0001578 biolink:NamedThing microtubule bundle formation A process that results in a parallel arrangement of microtubules. RBO_relaxed.owl GO:0007020 biolink:NamedThing microtubule nucleation The process in which tubulin alpha-beta heterodimers begin aggregation to form an oligomeric tubulin structure (a microtubule seed). Microtubule nucleation is the initiating step in the formation of a microtubule in the absence of any existing microtubules ('de novo' microtubule formation). RBO_relaxed.owl GO:0030951 biolink:NamedThing establishment or maintenance of microtubule cytoskeleton polarity Any cellular process that results in the specification, formation or maintenance of polarized microtubule-based cytoskeletal structures. RBO_relaxed.owl GO:0031109 biolink:NamedThing microtubule polymerization or depolymerization Assembly or disassembly of microtubules by the addition or removal of tubulin heterodimers from a microtubule. RBO_relaxed.owl GO:0001659 biolink:NamedThing temperature homeostasis A homeostatic process in which an organism modulates its internal body temperature. RBO_relaxed.owl GO:0048872 biolink:NamedThing homeostasis of number of cells Any biological process involved in the maintenance of the steady-state number of cells within a population of cells. RBO_relaxed.owl GO:0001666 biolink:NamedThing response to hypoxia Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level. RBO_relaxed.owl GO:0006950 biolink:NamedThing response to stress Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). RBO_relaxed.owl GO:0033554 biolink:NamedThing cellular response to stress Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). RBO_relaxed.owl GO:0036293 biolink:NamedThing response to decreased oxygen levels Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting a decline in the level of oxygen. RBO_relaxed.owl GO:0001667 biolink:NamedThing ameboidal-type cell migration Cell migration that is accomplished by extension and retraction of a pseudopodium. RBO_relaxed.owl GO:0016477 biolink:NamedThing cell migration The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. RBO_relaxed.owl GO:0003273 biolink:NamedThing cell migration involved in endocardial cushion formation The orderly movement of a cell from one site to another that will contribute to the formation of an endocardial cushion. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves. RBO_relaxed.owl GO:0021535 biolink:NamedThing cell migration in hindbrain The orderly movement of a cell that will reside in the hindbrain. RBO_relaxed.owl GO:0022035 biolink:NamedThing rhombomere cell migration The movement of a cell within a rhombomere. This process is known to occur as an early step in the generation of anatomical structure from a rhombomere. RBO_relaxed.owl GO:0035441 biolink:NamedThing cell migration involved in vasculogenesis The orderly movement of a cell from one site to another that will contribute to the differentiation of an endothelial cell that will form de novo blood vessels and tubes. RBO_relaxed.owl GO:0042074 biolink:NamedThing cell migration involved in gastrulation The migration of individual cells within the blastocyst to help establish the multi-layered body plan of the organism (gastrulation). For example, the migration of cells from the surface to the interior of the embryo (ingression). RBO_relaxed.owl GO:0060973 biolink:NamedThing cell migration involved in heart development The orderly movement of a cell from one site to another that will contribute to the progression of the heart over time, from its initial formation, to the mature organ. RBO_relaxed.owl GO:0060974 biolink:NamedThing cell migration involved in heart formation The orderly movement of a cell from one site to another that contribute to the formation of the heart. The initial heart structure is made up of mesoderm-derived heart progenitor cells and neural crest-derived cells. RBO_relaxed.owl GO:0060980 biolink:NamedThing cell migration involved in coronary vasculogenesis The orderly movement of a cell from one site to another that will contribute to the differentiation of an endothelial cell that will form the blood vessels of the heart. RBO_relaxed.owl GO:0060981 biolink:NamedThing cell migration involved in coronary angiogenesis The orderly movement of a cell from one site to another that will contribute to the formation of new blood vessels in the heart from pre-existing blood vessels. RBO_relaxed.owl GO:0001677 biolink:NamedThing formation of translation initiation ternary complex Formation of a complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2 (either eIF2 in eukaryotes, or IF2 in prokaryotes). In prokaryotes, fMet-tRNA (initiator) is used rather than Met-tRNA (initiator). RBO_relaxed.owl GO:0014866 biolink:NamedThing skeletal myofibril assembly The process whose specific outcome is the progression of the skeletal myofibril over time, from its formation to the mature structure. A skeletal myofibril is a myofibril specific to skeletal muscle cells. RBO_relaxed.owl GO:0022618 biolink:NamedThing protein-RNA complex assembly The aggregation, arrangement and bonding together of proteins and RNA molecules to form a ribonucleoprotein complex. RBO_relaxed.owl GO:0030031 biolink:NamedThing cell projection assembly Formation of a prolongation or process extending from a cell, e.g. a flagellum or axon. RBO_relaxed.owl GO:0030033 biolink:NamedThing microvillus assembly Formation of a microvillus, a thin cylindrical membrane-covered projection on the surface of a cell. RBO_relaxed.owl GO:0030239 biolink:NamedThing myofibril assembly Formation of myofibrils, the repeating units of striated muscle. RBO_relaxed.owl GO:0032060 biolink:NamedThing bleb assembly The assembly of a bleb, a cell extension caused by localized decoupling of the cytoskeleton from the plasma membrane and characterized by rapid formation, rounded shape, and scarcity of organelles within the protrusion. Plasma membrane blebbing occurs during apoptosis and other cellular processes, including cell locomotion, cell division, and as a result of physical or chemical stresses. RBO_relaxed.owl GO:0034329 biolink:NamedThing cell junction assembly A cellular process that results in the aggregation, arrangement and bonding together of a set of components to form a cell junction. RBO_relaxed.owl GO:0035082 biolink:NamedThing axoneme assembly The assembly and organization of an axoneme, the bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements. RBO_relaxed.owl GO:0042255 biolink:NamedThing ribosome assembly The aggregation, arrangement and bonding together of the mature ribosome and of its subunits. RBO_relaxed.owl GO:0046785 biolink:NamedThing microtubule polymerization The addition of tubulin heterodimers to one or both ends of a microtubule. RBO_relaxed.owl GO:0048251 biolink:NamedThing elastic fiber assembly Assembly of the extracellular matrix fibers that enables the matrix to recoil after transient stretching. RBO_relaxed.owl GO:0051017 biolink:NamedThing actin filament bundle assembly The assembly of actin filament bundles; actin filaments are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness. RBO_relaxed.owl GO:0055003 biolink:NamedThing cardiac myofibril assembly The process whose specific outcome is the progression of the cardiac myofibril over time, from its formation to the mature structure. A cardiac myofibril is a myofibril specific to cardiac muscle cells. RBO_relaxed.owl GO:0060271 biolink:NamedThing cilium assembly The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole. RBO_relaxed.owl GO:0065003 biolink:NamedThing protein-containing complex assembly The aggregation, arrangement and bonding together of a set of macromolecules to form a protein-containing complex. RBO_relaxed.owl GO:0065004 biolink:NamedThing protein-DNA complex assembly The aggregation, arrangement and bonding together of proteins and DNA molecules to form a protein-DNA complex. RBO_relaxed.owl GO:0070831 biolink:NamedThing basement membrane assembly The aggregation, arrangement and bonding together of a set of components to form a basement membrane, a part of the extracellular region that consists of a thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. RBO_relaxed.owl GO:0070925 biolink:NamedThing organelle assembly The aggregation, arrangement and bonding together of a set of components to form an organelle. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane. RBO_relaxed.owl GO:0071709 biolink:NamedThing membrane assembly The aggregation, arrangement and bonding together of a set of components to form a membrane. RBO_relaxed.owl GO:0071971 biolink:NamedThing extracellular exosome assembly The aggregation, arrangement and bonding together of a set of components to form an extracellular vesicular exosome, a membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Exosomes are defined by their size, which generally ranges from 30 nm to 100 nm. RBO_relaxed.owl GO:0085029 biolink:NamedThing extracellular matrix assembly The aggregation, arrangement and bonding together of the extracellular matrix. RBO_relaxed.owl GO:0090168 biolink:NamedThing Golgi reassembly The reformation of the Golgi following its breakdown and partitioning contributing to Golgi inheritance. RBO_relaxed.owl GO:0099054 biolink:NamedThing presynapse assembly The aggregation, arrangement and bonding together of a set of components to form a presynapse. RBO_relaxed.owl GO:0099068 biolink:NamedThing postsynapse assembly The aggregation, arrangement and bonding together of a set of components to form a postsynapse. RBO_relaxed.owl GO:0120031 biolink:NamedThing plasma membrane bounded cell projection assembly Formation of a prolongation or process extending and that is bounded by plasma membrane, e.g. a cilium, lamellipodium, or axon. RBO_relaxed.owl GO:0140694 biolink:NamedThing non-membrane-bounded organelle assembly The aggregation, arrangement and bonding together of a set of components to form a non-membrane-bounded organelle. RBO_relaxed.owl GO:1905349 biolink:NamedThing ciliary transition zone assembly The aggregation, arrangement and bonding together of a set of components to form a ciliary transition zone. RBO_relaxed.owl GO:0001696 biolink:NamedThing gastric acid secretion The regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion. RBO_relaxed.owl GO:0022600 biolink:NamedThing digestive system process A physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism. RBO_relaxed.owl GO:0030421 biolink:NamedThing defecation The expulsion of feces from the rectum. RBO_relaxed.owl GO:0043133 biolink:NamedThing hindgut contraction A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the hindgut. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The hindgut is the posterior part of the alimentary canal, including the rectum, and the large intestine. RBO_relaxed.owl GO:0071626 biolink:NamedThing mastication The process of biting and mashing food with the teeth prior to swallowing. RBO_relaxed.owl GO:0046717 biolink:NamedThing acid secretion The controlled release of acid by a cell or a tissue. RBO_relaxed.owl GO:0032782 biolink:NamedThing bile acid secretion The regulated release of bile acid, composed of any of a group of steroid carboxylic acids occurring in bile, by a cell or a tissue. RBO_relaxed.owl GO:0001700 biolink:NamedThing embryonic development via the syncytial blastoderm The process whose specific outcome is the progression of the embryo over time, from zygote formation through syncytial blastoderm to the hatching of the first instar larva. An example of this process is found in Drosophila melanogaster. RBO_relaxed.owl GO:0009792 biolink:NamedThing embryo development ending in birth or egg hatching The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism-specific and may be somewhat arbitrary; for mammals it is usually considered to be birth, for insects the hatching of the first instar larva from the eggshell. RBO_relaxed.owl GO:0043009 biolink:NamedThing chordate embryonic development The process whose specific outcome is the progression of the embryo over time, from zygote formation through a stage including a notochord and neural tube until birth or egg hatching. RBO_relaxed.owl GO:0001701 biolink:NamedThing in utero embryonic development The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus. RBO_relaxed.owl GO:0048048 biolink:NamedThing embryonic eye morphogenesis The process occurring in the embryo by which the anatomical structures of the post-embryonic eye are generated and organized. RBO_relaxed.owl GO:0009952 biolink:NamedThing anterior/posterior pattern specification The regionalization process in which specific areas of cell differentiation are determined along the anterior-posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism. RBO_relaxed.owl GO:0021903 biolink:NamedThing rostrocaudal neural tube patterning The process in which the neural tube is divided into specific regions along the rostrocaudal axis. RBO_relaxed.owl GO:0021999 biolink:NamedThing neural plate anterior/posterior regionalization The process that regulates the coordinated growth and differentiation that establishes the non-random anterior-posterior spatial arrangement of the neural plate. RBO_relaxed.owl GO:0035282 biolink:NamedThing segmentation The regionalization process that divides an organism or part of an organism into a series of semi-repetitive parts, or segments, often arranged along a longitudinal axis. RBO_relaxed.owl GO:0001776 biolink:NamedThing leukocyte homeostasis The process of regulating the proliferation and elimination of cells of the immune system such that the total number of cells of a particular cell type within a whole or part of an organism is stable over time in the absence of an outside stimulus. RBO_relaxed.owl GO:0002252 biolink:NamedThing immune effector process Any process of the immune system that executes a component of an immune response. An effector immune process takes place after its activation. RBO_relaxed.owl GO:0002262 biolink:NamedThing myeloid cell homeostasis The process of regulating the proliferation and elimination of myeloid cells such that the total number of myeloid cells within a whole or part of an organism is stable over time in the absence of an outside stimulus. RBO_relaxed.owl GO:0002443 biolink:NamedThing leukocyte mediated immunity Any process involved in the carrying out of an immune response by a leukocyte. RBO_relaxed.owl GO:0002444 biolink:NamedThing myeloid leukocyte mediated immunity Any process involved in the carrying out of an immune response by a myeloid leukocyte. RBO_relaxed.owl GO:0006955 biolink:NamedThing immune response Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. RBO_relaxed.owl GO:0034101 biolink:NamedThing erythrocyte homeostasis Any process of regulating the production and elimination of erythrocytes within an organism. RBO_relaxed.owl GO:0036333 biolink:NamedThing hepatocyte homeostasis Any biological process involved in the maintenance of the steady-state number of hepatocytes within a population of cells. Hepatocytes are specialized epithelial cells of the liver that are organized into interconnected plates called lobules. RBO_relaxed.owl GO:0036334 biolink:NamedThing epidermal stem cell homeostasis Any biological process involved in the maintenance of the steady-state number of epidermal stem cells within a population of cells. RBO_relaxed.owl GO:0061484 biolink:NamedThing hematopoietic stem cell homeostasis Any biological process involved in the maintenance of the steady-state number of hematopoietic stem cells within a population of cells. RBO_relaxed.owl GO:0001820 biolink:NamedThing serotonin secretion The regulated release of serotonin by a cell. Serotonin (5-hydroxytryptamine, or 5-HT) is a monoamine synthesised in serotonergic neurons in the central nervous system, enterochromaffin cells in the gastrointestinal tract and some immune system cells. RBO_relaxed.owl GO:0006837 biolink:NamedThing serotonin transport The directed movement of serotonin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Serotonin (5-hydroxytryptamine) is a monoamine neurotransmitter occurring in the peripheral and central nervous systems. RBO_relaxed.owl GO:0023061 biolink:NamedThing signal release The process in which a signal is secreted or discharged into the extracellular medium from a cellular source. RBO_relaxed.owl GO:0046879 biolink:NamedThing hormone secretion The regulated release of hormones, substances with a specific regulatory effect on a particular organ or group of cells. RBO_relaxed.owl GO:0048243 biolink:NamedThing norepinephrine secretion The regulated release of norepinephrine by a cell. Norepinephrine is a catecholamine and it acts as a hormone and as a neurotransmitter of most of the sympathetic nervous system. RBO_relaxed.owl GO:0061526 biolink:NamedThing acetylcholine secretion The regulated release of acetylcholine by a cell. RBO_relaxed.owl GO:0099643 biolink:NamedThing signal release from synapse Any signal release from a synapse. RBO_relaxed.owl GO:0046903 biolink:NamedThing secretion The controlled release of a substance by a cell or a tissue. RBO_relaxed.owl GO:0002790 biolink:NamedThing peptide secretion The controlled release of a peptide from a cell or a tissue. RBO_relaxed.owl GO:0007589 biolink:NamedThing body fluid secretion The controlled release of a fluid by a cell or tissue in an animal. RBO_relaxed.owl GO:0009306 biolink:NamedThing protein secretion The controlled release of proteins from a cell. RBO_relaxed.owl GO:0030072 biolink:NamedThing peptide hormone secretion The regulated release of a peptide hormone from a cell. RBO_relaxed.owl GO:0030073 biolink:NamedThing insulin secretion The regulated release of proinsulin from secretory granules accompanied by cleavage of proinsulin to form mature insulin. In vertebrates, insulin is secreted from B granules in the B cells of the vertebrate pancreas and from insulin-producing cells in insects. RBO_relaxed.owl GO:0032940 biolink:NamedThing secretion by cell The controlled release of a substance by a cell. RBO_relaxed.owl GO:0035929 biolink:NamedThing steroid hormone secretion The regulated release of any steroid that acts as a hormone into the circulatory system. RBO_relaxed.owl GO:0050432 biolink:NamedThing catecholamine secretion The regulated release of catecholamines by a cell. The catecholamines are a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine. RBO_relaxed.owl GO:0070091 biolink:NamedThing glucagon secretion The regulated release of glucagon from secretory granules in the A (alpha) cells of the pancreas (islets of Langerhans). RBO_relaxed.owl GO:0070253 biolink:NamedThing somatostatin secretion The regulated release of somatostatin from secretory granules in the D cells of the pancreas. RBO_relaxed.owl GO:0070254 biolink:NamedThing mucus secretion The regulated release of mucus by the mucosa. Mucus is a viscous slimy secretion consisting of mucins and various inorganic salts dissolved in water, with suspended epithelial cells and leukocytes. The mucosa, or mucous membrane, is the membrane covered with epithelium that lines the tubular organs of the body. Mucins are carbohydrate-rich glycoproteins that have a lubricating and protective function. RBO_relaxed.owl GO:0048667 biolink:NamedThing cell morphogenesis involved in neuron differentiation The process in which the structures of a neuron are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a neuron. RBO_relaxed.owl GO:0003152 biolink:NamedThing morphogenesis of an epithelial fold involved in embryonic heart tube formation The morphogenetic process in which an epithelial sheet bends along a linear axis, contributing to embryonic heart tube formation. RBO_relaxed.owl GO:0007369 biolink:NamedThing gastrulation A complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. The details of gastrulation vary from species to species, but usually result in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm. RBO_relaxed.owl GO:0016331 biolink:NamedThing morphogenesis of embryonic epithelium The process in which the anatomical structures of embryonic epithelia are generated and organized. RBO_relaxed.owl GO:0048562 biolink:NamedThing embryonic organ morphogenesis Morphogenesis, during the embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions. RBO_relaxed.owl GO:0003248 biolink:NamedThing heart capillary growth The increase in heart capillaries that accompanies physiological hypertrophy of cardiac muscle. RBO_relaxed.owl GO:0003416 biolink:NamedThing endochondral bone growth The increase in size or mass of an endochondral bone that contributes to the shaping of the bone. RBO_relaxed.owl GO:0048630 biolink:NamedThing skeletal muscle tissue growth The increase in size or mass of a skeletal muscle. This may be due to a change in the fiber number or size. RBO_relaxed.owl GO:0055017 biolink:NamedThing cardiac muscle tissue growth The increase in size or mass of a cardiac muscle, where the increase in size or mass has the specific outcome of the progression of the organism over time from one condition to another. RBO_relaxed.owl GO:0060419 biolink:NamedThing heart growth The increase in size or mass of the heart. RBO_relaxed.owl GO:0060437 biolink:NamedThing lung growth The increase in size or mass of a lung. In all air-breathing vertebrates the lungs are developed from the ventral wall of the oesophagus as a pouch which divides into two sacs. In amphibians and many reptiles the lungs retain very nearly this primitive sac-like character, but in the higher forms the connection with the esophagus becomes elongated into the windpipe and the inner walls of the sacs become more and more divided, until, in the mammals, the air spaces become minutely divided into tubes ending in small air cells, in the walls of which the blood circulates in a fine network of capillaries. In mammals the lungs are more or less divided into lobes, and each lung occupies a separate cavity in the thorax. RBO_relaxed.owl GO:0060560 biolink:NamedThing developmental growth involved in morphogenesis The increase in size or mass of an anatomical structure that contributes to the structure attaining its shape. RBO_relaxed.owl GO:0098867 biolink:NamedThing intramembranous bone growth The increase in size or mass of an intramembranous bone that contributes to the shaping of the bone. RBO_relaxed.owl GO:0098868 biolink:NamedThing bone growth The increase in size or mass of a bone that contributes to the shaping of that bone. RBO_relaxed.owl GO:0001833 biolink:NamedThing inner cell mass cell proliferation The proliferation of cells in the inner cell mass. RBO_relaxed.owl GO:0008283 biolink:NamedThing cell population proliferation The multiplication or reproduction of cells, resulting in the expansion of a cell population. RBO_relaxed.owl GO:0001834 biolink:NamedThing trophectodermal cell proliferation The proliferation of cells in the trophectoderm. RBO_relaxed.owl GO:0001935 biolink:NamedThing endothelial cell proliferation The multiplication or reproduction of endothelial cells, resulting in the expansion of a cell population. Endothelial cells are thin flattened cells which line the inside surfaces of body cavities, blood vessels, and lymph vessels, making up the endothelium. RBO_relaxed.owl GO:0007405 biolink:NamedThing neuroblast proliferation The expansion of a neuroblast population by cell division. A neuroblast is any cell that will divide and give rise to a neuron. RBO_relaxed.owl GO:0010463 biolink:NamedThing mesenchymal cell proliferation The multiplication or reproduction of cells, resulting in the expansion of a mesenchymal cell population. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets. RBO_relaxed.owl GO:0014009 biolink:NamedThing glial cell proliferation The multiplication or reproduction of glial cells by cell division, resulting in the expansion of their population. Glial cells exist throughout the nervous system, and include Schwann cells, astrocytes, and oligodendrocytes among others. RBO_relaxed.owl GO:0014855 biolink:NamedThing striated muscle cell proliferation The multiplication or reproduction of striated muscle cells, resulting in the expansion of a cell population. Striated muscles contain fibers that are divided by transverse bands into striations, and cardiac and skeletal muscle are types of striated muscle. RBO_relaxed.owl GO:0014856 biolink:NamedThing skeletal muscle cell proliferation The multiplication or reproduction of skeletal muscle cells, resulting in the expansion of a cell population. RBO_relaxed.owl GO:0021534 biolink:NamedThing cell proliferation in hindbrain The multiplication or reproduction of cells, resulting in the expansion of a cell population in the hindbrain. RBO_relaxed.owl GO:0032943 biolink:NamedThing mononuclear cell proliferation The expansion of a mononuclear cell population by cell division. A mononuclear cell is a leukocyte with a single non-segmented nucleus in the mature form. RBO_relaxed.owl GO:0033002 biolink:NamedThing muscle cell proliferation The expansion of a muscle cell population by cell division. RBO_relaxed.owl GO:0033278 biolink:NamedThing cell proliferation in midbrain The multiplication or reproduction of cells, resulting in the expansion of a cell population in the midbrain. RBO_relaxed.owl GO:0035736 biolink:NamedThing cell proliferation involved in compound eye morphogenesis The multiplication or reproduction of cells, resulting in the expansion of a cell population that contributes to compound eye morphogenesis. RBO_relaxed.owl GO:0044342 biolink:NamedThing type B pancreatic cell proliferation The multiplication or reproduction of pancreatic B cells, resulting in the expansion of an pancreatic B cell population. Pancreatic B cell are cells of the pancreas that secrete insulin. RBO_relaxed.owl GO:0048144 biolink:NamedThing fibroblast proliferation The multiplication or reproduction of fibroblast cells, resulting in the expansion of the fibroblast population. RBO_relaxed.owl GO:0048659 biolink:NamedThing smooth muscle cell proliferation The multiplication or reproduction of smooth muscle cells, resulting in the expansion of a cell population. RBO_relaxed.owl GO:0050673 biolink:NamedThing epithelial cell proliferation The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population. Epithelial cells make up the epithelium, the covering of internal and external surfaces of the body, including the lining of vessels and other small cavities. It consists of cells joined by small amounts of cementing substances. RBO_relaxed.owl GO:0051450 biolink:NamedThing myoblast proliferation The multiplication or reproduction of myoblasts, resulting in the expansion of a myoblast cell population. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. RBO_relaxed.owl GO:0060038 biolink:NamedThing cardiac muscle cell proliferation The expansion of a cardiac muscle cell population by cell division. RBO_relaxed.owl GO:0061323 biolink:NamedThing cell proliferation involved in heart morphogenesis The multiplication or reproduction of cells, resulting in the expansion of a cell population that contributes to the shaping of the heart. RBO_relaxed.owl GO:0061325 biolink:NamedThing cell proliferation involved in outflow tract morphogenesis The multiplication or reproduction of cells, resulting in the expansion of a cell population that contributes to the shaping of the outflow tract. RBO_relaxed.owl GO:0061351 biolink:NamedThing neural precursor cell proliferation The multiplication or reproduction of neural precursor cells, resulting in the expansion of a cell population. A neural precursor cell is either a nervous system stem cell or a nervous system progenitor cell. RBO_relaxed.owl GO:0070341 biolink:NamedThing fat cell proliferation The multiplication or reproduction of fat cells by cell division, resulting in the expansion of their population. A fat cell is an animal connective tissue cell specialized for the synthesis and storage of fat. RBO_relaxed.owl GO:0070661 biolink:NamedThing leukocyte proliferation The expansion of a leukocyte population by cell division. RBO_relaxed.owl GO:0071425 biolink:NamedThing hematopoietic stem cell proliferation The expansion of a hematopoietic stem cell population by cell division. A hematopoietic stem cell is a stem cell from which all cells of the lymphoid and myeloid lineages develop. RBO_relaxed.owl GO:0072089 biolink:NamedThing stem cell proliferation The multiplication or reproduction of stem cells, resulting in the expansion of a stem cell population. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells. RBO_relaxed.owl GO:0101023 biolink:NamedThing vascular endothelial cell proliferation The multiplication or reproduction of blood vessel endothelial cells, resulting in the expansion of a cell population. RBO_relaxed.owl GO:0110021 biolink:NamedThing cardiac muscle myoblast proliferation The multiplication or reproduction of cardiac muscle myoblasts, resulting in the expansion of a cardiac muscle myoblast cell population. A cardiac myoblast is a precursor cell that has been committed to a cardiac muscle cell fate but retains the ability to divide and proliferate throughout life. RBO_relaxed.owl GO:1905315 biolink:NamedThing cell proliferation involved in endocardial cushion morphogenesis Any cell proliferation that is involved in endocardial cushion morphogenesis. RBO_relaxed.owl GO:1990705 biolink:NamedThing cholangiocyte proliferation The multiplication or reproduction of cholangiocytes, resulting in the expansion of the cholangiocyte population. A cholangiocyte is an epithelial cell that is part of the bile duct. Cholangiocytes contribute to bile secretion via net release of bicarbonate and water. RBO_relaxed.owl GO:1990863 biolink:NamedThing acinar cell proliferation The multiplication or reproduction of acinar cells, resulting in the expansion of a cell population. An acinar cell is a secretory cell that is grouped together with other cells of the same type to form grape-shaped clusters known as acini (singular acinus). RBO_relaxed.owl GO:1990874 biolink:NamedThing vascular associated smooth muscle cell proliferation The multiplication or reproduction of vascular smooth muscle cells, resulting in the expansion of a cell population. A vascular smooth muscle cell is a non-striated, elongated, spindle-shaped cell found lining the blood vessels. RBO_relaxed.owl GO:0060915 biolink:NamedThing mesenchymal cell differentiation involved in lung development The process in which a relatively unspecialized cell acquires specialized features of a mesenchymal cell of the lung. A mesenchymal cell is a loosely associated cell that is part of the connective tissue in an organism. Mesenchymal cells give rise to more mature connective tissue cell types. RBO_relaxed.owl GO:1901706 biolink:NamedThing mesenchymal cell differentiation involved in bone development The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mesenchymal cells of bone as it progresses from its formation to the mature state. RBO_relaxed.owl GO:2001012 biolink:NamedThing mesenchymal cell differentiation involved in renal system development The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mesenchymal cells of the renal system as it progresses from its formation to the mature state. RBO_relaxed.owl GO:0001838 biolink:NamedThing embryonic epithelial tube formation The morphogenesis of an embryonic epithelium into a tube-shaped structure. RBO_relaxed.owl GO:0072175 biolink:NamedThing epithelial tube formation The developmental process pertaining to the initial formation of an epithelial tube. RBO_relaxed.owl GO:0120331 biolink:NamedThing endothelial tube formation The developmental process pertaining to the initial formation of an endothelial tube. RBO_relaxed.owl GO:0014020 biolink:NamedThing primary neural tube formation The formation of the neural tube from an epithelial cell sheet (the neuroepithelium or neural plate). In primary neurulation, the cells surrounding the neural plate direct the neural plate cells to proliferate, invaginate, and pinch off from the surface to form a hollow epithelial tube. Primary neurulation is the typical mechanism of formation of the anterior neural tube. RBO_relaxed.owl GO:0001878 biolink:NamedThing response to yeast Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a yeast species. RBO_relaxed.owl GO:0009620 biolink:NamedThing response to fungus Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a fungus. RBO_relaxed.owl GO:0009416 biolink:NamedThing response to light stimulus Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light. RBO_relaxed.owl GO:0009605 biolink:NamedThing response to external stimulus Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus. RBO_relaxed.owl GO:0009607 biolink:NamedThing response to biotic stimulus Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism. RBO_relaxed.owl GO:0009617 biolink:NamedThing response to bacterium Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium. RBO_relaxed.owl GO:0009628 biolink:NamedThing response to abiotic stimulus Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abiotic (not derived from living organisms) stimulus. RBO_relaxed.owl GO:0009719 biolink:NamedThing response to endogenous stimulus Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus arising within the organism. RBO_relaxed.owl GO:0009743 biolink:NamedThing response to carbohydrate Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbohydrate stimulus. RBO_relaxed.owl GO:0009746 biolink:NamedThing response to hexose Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hexose stimulus. RBO_relaxed.owl GO:0009749 biolink:NamedThing response to glucose Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus. RBO_relaxed.owl GO:0010034 biolink:NamedThing response to acetate Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acetate stimulus. RBO_relaxed.owl GO:0010038 biolink:NamedThing response to metal ion Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a metal ion stimulus. RBO_relaxed.owl GO:0010243 biolink:NamedThing response to organonitrogen compound Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organonitrogen stimulus. An organonitrogen compound is formally a compound containing at least one carbon-nitrogen bond. RBO_relaxed.owl GO:0014070 biolink:NamedThing response to organic cyclic compound Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus. RBO_relaxed.owl GO:0014075 biolink:NamedThing response to amine Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amine stimulus. An amine is a compound formally derived from ammonia by replacing one, two or three hydrogen atoms by hydrocarbyl groups. RBO_relaxed.owl GO:0014874 biolink:NamedThing response to stimulus involved in regulation of muscle adaptation Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. This occurs as part of the regulation of muscle adaptation. RBO_relaxed.owl GO:0033762 biolink:NamedThing response to glucagon Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucagon stimulus. RBO_relaxed.owl GO:0033993 biolink:NamedThing response to lipid Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipid stimulus. RBO_relaxed.owl GO:0034284 biolink:NamedThing response to monosaccharide Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a monosaccharide stimulus. RBO_relaxed.owl GO:0043200 biolink:NamedThing response to amino acid Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amino acid stimulus. An amino acid is a carboxylic acids containing one or more amino groups. RBO_relaxed.owl GO:0043279 biolink:NamedThing response to alkaloid Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alkaloid stimulus. Alkaloids are a large group of nitrogenous substances found in naturally in plants, many of which have extracts that are pharmacologically active. RBO_relaxed.owl GO:0043434 biolink:NamedThing response to peptide hormone Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals. RBO_relaxed.owl GO:0043500 biolink:NamedThing muscle adaptation A process in which muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities. RBO_relaxed.owl GO:0046681 biolink:NamedThing response to carbamate Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbamate stimulus. Carbamates are a group of insecticides and parasiticides that act by inhibiting cholinesterase. RBO_relaxed.owl GO:0048545 biolink:NamedThing response to steroid hormone Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a steroid hormone stimulus. RBO_relaxed.owl GO:0051606 biolink:NamedThing detection of stimulus The series of events in which a stimulus is received by a cell or organism and converted into a molecular signal. RBO_relaxed.owl GO:0051707 biolink:NamedThing response to other organism Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from another living organism. RBO_relaxed.owl GO:0051716 biolink:NamedThing cellular response to stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus by a cell and ends with a change in state or activity or the cell. RBO_relaxed.owl GO:0060359 biolink:NamedThing response to ammonium ion Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ammonium stimulus. RBO_relaxed.owl GO:0071867 biolink:NamedThing response to monoamine Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a monoamine stimulus. A monoamine is any of a group of molecular messengers that contain one amino group that is connected to an aromatic ring by ethylene group (-CH2-CH2-). Monoamines are derived from the aromatic amino acids phenylalanine, tyrosine, histidine and tryptophan. RBO_relaxed.owl GO:0071869 biolink:NamedThing response to catecholamine Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a catecholamine stimulus. A catecholamine is any of a group of biogenic amines that includes 4-(2-aminoethyl)pyrocatechol [4-(2-aminoethyl)benzene-1,2-diol] and derivatives formed by substitution. RBO_relaxed.owl GO:0071873 biolink:NamedThing response to norepinephrine Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a norepinephrine stimulus. Norepinephrine is a catecholamine that has the formula C8H11NO3; it acts as a hormone, and as a neurotransmitter in most of the sympathetic nervous system. RBO_relaxed.owl GO:1901652 biolink:NamedThing response to peptide Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide stimulus. RBO_relaxed.owl GO:1901654 biolink:NamedThing response to ketone A response that results in a state of tolerance to ketone. RBO_relaxed.owl GO:1903412 biolink:NamedThing response to bile acid Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bile acid stimulus. RBO_relaxed.owl GO:1904014 biolink:NamedThing response to serotonin Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a serotonin stimulus. RBO_relaxed.owl GO:1904587 biolink:NamedThing response to glycoprotein Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glycoprotein stimulus. RBO_relaxed.owl GO:1905144 biolink:NamedThing response to acetylcholine Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acetylcholine stimulus. RBO_relaxed.owl GO:0001885 biolink:NamedThing endothelial cell development The progression of an endothelial cell over time, from its formation to the mature structure. RBO_relaxed.owl GO:0002064 biolink:NamedThing epithelial cell development The process whose specific outcome is the progression of an epithelial cell over time, from its formation to the mature structure. An epithelial cell is a cell usually found in a two-dimensional sheet with a free surface. RBO_relaxed.owl GO:0002066 biolink:NamedThing columnar/cuboidal epithelial cell development The process whose specific outcome is the progression of a columnar/cuboidal epithelial cell over time, from its formation to the mature structure. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube. RBO_relaxed.owl GO:0002063 biolink:NamedThing chondrocyte development The process whose specific outcome is the progression of a chondrocyte over time, from its commitment to its mature state. Chondrocyte development does not include the steps involved in committing a chondroblast to a chondrocyte fate. RBO_relaxed.owl GO:0002068 biolink:NamedThing glandular epithelial cell development The process whose specific outcome is the progression of a glandular epithelial cell over time, from its formation to the mature structure. A glandular epithelial cell is a columnar/cuboidal epithelial cell is a cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland. RBO_relaxed.owl GO:0003322 biolink:NamedThing pancreatic A cell development The process whose specific outcome is the progression of a pancreatic A cell over time, from its formation to the mature structure. A pancreatic A cell is a cell in the pancreas that secretes glucagon. RBO_relaxed.owl GO:0003323 biolink:NamedThing type B pancreatic cell development The process whose specific outcome is the progression of a type B pancreatic cell over time, from its formation to the mature structure. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin. RBO_relaxed.owl GO:0003324 biolink:NamedThing pancreatic D cell development The process whose specific outcome is the progression of a pancreatic delta cell over time, from its formation to the mature structure. A delta cell is a cell of the pancreas that produces somatostatin. RBO_relaxed.owl GO:0003358 biolink:NamedThing noradrenergic neuron development The process whose specific outcome is the progression of a noradrenergic neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. RBO_relaxed.owl GO:0014019 biolink:NamedThing neuroblast development The process aimed at the progression of a neuroblast over time, from initial commitment of the cell to a specific state, to the mature neuroblast. It does not include processes where the neuroblast turns into a glial cell or a neuron. RBO_relaxed.owl GO:0014031 biolink:NamedThing mesenchymal cell development The process aimed at the progression of a mesenchymal cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell. RBO_relaxed.owl GO:0014032 biolink:NamedThing neural crest cell development The process aimed at the progression of a neural crest cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell. RBO_relaxed.owl GO:0014904 biolink:NamedThing myotube cell development The process aimed at the progression of a myotube cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse. RBO_relaxed.owl GO:0021782 biolink:NamedThing glial cell development The process aimed at the progression of a glial cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. RBO_relaxed.owl GO:0030097 biolink:NamedThing hemopoiesis The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates. RBO_relaxed.owl GO:0031128 biolink:NamedThing developmental induction A developmental process involving two tissues in which one tissue (the inducer) produces a signal that directs cell fate commitment of cells in the second tissue (the responder). RBO_relaxed.owl GO:0042461 biolink:NamedThing photoreceptor cell development Development of a photoreceptor, a cell that responds to incident electromagnetic radiation, particularly visible light. RBO_relaxed.owl GO:0042462 biolink:NamedThing eye photoreceptor cell development Development of a photoreceptor, a sensory cell in the eye that reacts to the presence of light. They usually contain a pigment that undergoes a chemical change when light is absorbed, thus stimulating a nerve. RBO_relaxed.owl GO:0046548 biolink:NamedThing retinal rod cell development Development of a rod cell, one of the sensory cells in the eye that reacts to the presence of light. Rod cells contain the photopigment rhodopsin or porphyropsin and are responsible for vision in dim light. RBO_relaxed.owl GO:0046549 biolink:NamedThing retinal cone cell development Development of a cone cell, one of the sensory cells in the eye that reacts to the presence of light. Cone cells contain the photopigment iodopsin or cyanopsin and are responsible for photopic (daylight) vision. RBO_relaxed.owl GO:0048599 biolink:NamedThing oocyte development The process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell. RBO_relaxed.owl GO:0048627 biolink:NamedThing myoblast development The process whose specific outcome is the progression of the myoblast over time, from its formation to the mature structure. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. RBO_relaxed.owl GO:0048666 biolink:NamedThing neuron development The process whose specific outcome is the progression of a neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. RBO_relaxed.owl GO:0048821 biolink:NamedThing erythrocyte development The process whose specific outcome is the progression of an erythrocyte over time, from its formation to the mature structure. RBO_relaxed.owl GO:0048822 biolink:NamedThing enucleate erythrocyte development The process aimed at the progression of an enucleate erythrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. RBO_relaxed.owl GO:0048823 biolink:NamedThing nucleate erythrocyte development The process aimed at the progression of a nucleate erythrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. RBO_relaxed.owl GO:0048864 biolink:NamedThing stem cell development The process whose specific outcome is the progression of the stem cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to its specific fate. RBO_relaxed.owl GO:0048869 biolink:NamedThing cellular developmental process A biological process whose specific outcome is the progression of a cell over time from an initial condition to a later condition. RBO_relaxed.owl GO:0055001 biolink:NamedThing muscle cell development The process whose specific outcome is the progression of a muscle cell over time, from its formation to the mature structure. Muscle cell development does not include the steps involved in committing an unspecified cell to the muscle cell fate. RBO_relaxed.owl GO:0055002 biolink:NamedThing striated muscle cell development The process whose specific outcome is the progression of a striated muscle cell over time, from its formation to the mature structure. Striated muscle cells contain fibers that are divided by transverse bands into striations, and cardiac and skeletal muscle are types of striated muscle. RBO_relaxed.owl GO:0055006 biolink:NamedThing cardiac cell development The process whose specific outcome is the progression of a cardiac cell over time, from its formation to the mature state. A cardiac cell is a cell that will form part of the cardiac organ of an individual. RBO_relaxed.owl GO:0055013 biolink:NamedThing cardiac muscle cell development The process whose specific outcome is the progression of a cardiac muscle cell over time, from its formation to the mature state. RBO_relaxed.owl GO:0070285 biolink:NamedThing pigment cell development The process whose specific outcome is the progression of a pigment cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a pigment cell fate. RBO_relaxed.owl GO:0098751 biolink:NamedThing bone cell development The process whose specific outcome is the progression of a bone cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. RBO_relaxed.owl GO:0003381 biolink:NamedThing epithelial cell morphogenesis involved in gastrulation The change in form that occurs when an epithelial cell progresses from it initial formation to its mature state, contributing to the process of gastrulation. RBO_relaxed.owl GO:0060502 biolink:NamedThing epithelial cell proliferation involved in lung morphogenesis The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population that contributes to the shaping of the lung. RBO_relaxed.owl GO:0072575 biolink:NamedThing epithelial cell proliferation involved in liver morphogenesis The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population that contributes to the shaping of the liver. RBO_relaxed.owl GO:0061553 biolink:NamedThing ganglion maturation A developmental process, independent of morphogenetic (shape) change, that is required for ganglion to attain its fully functional state. RBO_relaxed.owl GO:0061557 biolink:NamedThing trigeminal ganglion maturation A developmental process, independent of morphogenetic (shape) change, that is required for a trigeminal ganglion to attain its fully functional state. RBO_relaxed.owl GO:0061558 biolink:NamedThing cranial ganglion maturation A developmental process, independent of morphogenetic (shape) change, that is required for a cranial ganglion to attain its fully functional state. RBO_relaxed.owl GO:0001957 biolink:NamedThing intramembranous ossification Direct ossification that occurs within mesenchyme or an accumulation of relatively unspecialized cells. RBO_relaxed.owl GO:0036072 biolink:NamedThing direct ossification The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance, that does not require the replacement of preexisting tissues. RBO_relaxed.owl GO:0060415 biolink:NamedThing muscle tissue morphogenesis The process in which the anatomical structures of muscle tissue are generated and organized. Muscle tissue consists of a set of cells that are part of an organ and carry out a contractive function. RBO_relaxed.owl GO:0061138 biolink:NamedThing morphogenesis of a branching epithelium The process in which the anatomical structures of a branched epithelium are generated and organized. RBO_relaxed.owl GO:0002027 biolink:NamedThing regulation of heart rate Any process that modulates the frequency or rate of heart contraction. RBO_relaxed.owl GO:0061337 biolink:NamedThing cardiac conduction Transfer of an organized electrical impulse across the heart to coordinate the contraction of cardiac muscles. The process begins with generation of an action potential (in the sinoatrial node (SA) in humans) and ends with a change in the rate, frequency, or extent of the contraction of the heart muscles. RBO_relaxed.owl GO:0003325 biolink:NamedThing pancreatic PP cell development The process whose specific outcome is the progression of a pancreatic PP cell over time, from its formation to the mature structure. A pancreatic polypeptide-producing cell is a cell in the pancreas that produces pancreatic polypeptide. RBO_relaxed.owl GO:0021954 biolink:NamedThing central nervous system neuron development The process whose specific outcome is the progression of a neuron whose cell body is located in the central nervous system, from initial commitment of the cell to a neuronal fate, to the fully functional differentiated neuron. RBO_relaxed.owl GO:0048477 biolink:NamedThing oogenesis The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster. RBO_relaxed.owl GO:0048935 biolink:NamedThing peripheral nervous system neuron development The process whose specific outcome is the progression of a neuron whose cell body is located in the peripheral nervous system, from initial commitment of the cell to a neuronal fate, to the fully functional differentiated neuron. RBO_relaxed.owl GO:0060928 biolink:NamedThing atrioventricular node cell development The process whose specific outcome is the progression of an atrioventricular (AV) node cell over time, from its formation to the mature state. RBO_relaxed.owl GO:0060931 biolink:NamedThing sinoatrial node cell development The process whose specific outcome is the progression of a sinoatrial (SA) node cell over time, from its formation to the mature state. SA node cells are pacemaker cells that are found in the sinoatrial node. RBO_relaxed.owl GO:0060933 biolink:NamedThing His-Purkinje system cell development The process whose specific outcome is the progression of a His-Purkinje cell over time, from its formation to the mature state. These cells form the fibers that regulate cardiac muscle contraction in the ventricles. RBO_relaxed.owl GO:0060936 biolink:NamedThing cardiac fibroblast cell development The process whose specific outcome is the progression of a cardiac fibroblast over time, from its formation to the mature state. A cardiac fibroblast is a connective tissue cell of the heart which secretes an extracellular matrix rich in collagen and other macromolecules. RBO_relaxed.owl GO:0060952 biolink:NamedThing cardiac glial cell development The process aimed at the progression of a cardiac glial cell over time, from its formation to the fully functional mature cell. RBO_relaxed.owl GO:0060959 biolink:NamedThing cardiac neuron development The process whose specific outcome is the progression of a cardiac neuron over time, from its formation to the mature state. RBO_relaxed.owl GO:0061515 biolink:NamedThing myeloid cell development The process whose specific outcome is the progression of a myeloid cell over time, from its formation to the mature structure. RBO_relaxed.owl GO:0048505 biolink:NamedThing regulation of timing of cell differentiation The process controlling the activation and/or rate at which relatively unspecialized cells acquire specialized features. Any process that modulates the rate, frequency or extent of the XXX at a consistent predetermined time point during its development. RBO_relaxed.owl GO:0002087 biolink:NamedThing regulation of respiratory gaseous exchange by nervous system process A process carried out by the nervous system that is required for the proper control of respiratory gaseous exchange. This process occurs in the respiratory center of the brain in vertebrates. RBO_relaxed.owl GO:0050877 biolink:NamedThing nervous system process A organ system process carried out by any of the organs or tissues of neurological system. RBO_relaxed.owl GO:0007600 biolink:NamedThing sensory perception The series of events required for an organism to receive a sensory stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. RBO_relaxed.owl GO:0019226 biolink:NamedThing transmission of nerve impulse The neurological system process in which a signal is transmitted through the nervous system by a combination of action potential propagation and synaptic transmission. RBO_relaxed.owl GO:0050890 biolink:NamedThing cognition The operation of the mind by which an organism becomes aware of objects of thought or perception; it includes the mental activities associated with thinking, learning, and memory. RBO_relaxed.owl GO:0050905 biolink:NamedThing neuromuscular process Any process pertaining to the functions of the nervous and muscular systems of an organism. RBO_relaxed.owl GO:0099531 biolink:NamedThing presynaptic process involved in chemical synaptic transmission The pathway leading to secretion of a neurotransmitter from the presynapse as part of synaptic transmission. RBO_relaxed.owl GO:0002164 biolink:NamedThing larval development The process whose specific outcome is the progression of the larva over time, from its formation to the mature structure. The larva is the early, immature form of an that at birth or hatching is fundamentally unlike its parent and must metamorphose before assuming the adult characters. RBO_relaxed.owl GO:0002251 biolink:NamedThing organ or tissue specific immune response An immune response taking place in an organ or tissues such as the liver, brain, mucosa, or nervous system tissues. RBO_relaxed.owl GO:0002384 biolink:NamedThing hepatic immune response An immune response taking place in the liver. RBO_relaxed.owl GO:0014861 biolink:NamedThing regulation of skeletal muscle contraction via regulation of action potential Any process that modulates the frequency, rate or extent of skeletal muscle contraction by depolarization of muscle membrane and ionic fluxes. RBO_relaxed.owl GO:0023052 biolink:NamedThing signaling The entirety of a process in which information is transmitted within a biological system. This process begins with an active signal and ends when a cellular response has been triggered. RBO_relaxed.owl GO:0090326 biolink:NamedThing positive regulation of locomotion involved in locomotory behavior Any process that increases the frequency, rate, or extent of the self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement. RBO_relaxed.owl GO:0098900 biolink:NamedThing regulation of action potential Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination. This typically occurs via modulation of the activity or expression of voltage-gated ion channels. RBO_relaxed.owl GO:0098901 biolink:NamedThing regulation of cardiac muscle cell action potential Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a cardiac muscle cell. This typically occurs via modulation of the activity or expression of voltage-gated ion channels. RBO_relaxed.owl GO:0098904 biolink:NamedThing regulation of AV node cell action potential Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in an atrioventricular node myocyte. This typically occurs via modulation of the activity or expression of voltage-gated ion channels. RBO_relaxed.owl GO:0098906 biolink:NamedThing regulation of Purkinje myocyte action potential Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a Purkinje myocyte. This typically occurs via modulation of the activity or expression of voltage-gated ion channels. RBO_relaxed.owl GO:0098907 biolink:NamedThing regulation of SA node cell action potential Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in an SA node cardiac myocyte. This typically occurs via modulation of the activity or expression of voltage-gated ion channels. RBO_relaxed.owl GO:0098908 biolink:NamedThing regulation of neuronal action potential Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a neuron. This typically occurs via modulation of the activity or expression of voltage-gated ion channels. RBO_relaxed.owl GO:0015833 biolink:NamedThing peptide transport The directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. RBO_relaxed.owl GO:0003002 biolink:NamedThing regionalization The pattern specification process that results in the subdivision of an axis or axes in space to define an area or volume in which specific patterns of cell differentiation will take place or in which cells interpret a specific environment. RBO_relaxed.owl GO:0060896 biolink:NamedThing neural plate pattern specification The developmental process that results in the creation of defined areas or spaces within the neural plate to which cells respond and eventually are instructed to differentiate. RBO_relaxed.owl GO:0009566 biolink:NamedThing fertilization The union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy). RBO_relaxed.owl GO:0019098 biolink:NamedThing reproductive behavior The specific behavior of an organism that is associated with reproduction. RBO_relaxed.owl GO:0048609 biolink:NamedThing multicellular organismal reproductive process The process, occurring above the cellular level, that is pertinent to the reproductive function of a multicellular organism. This includes the integrated processes at the level of tissues and organs. RBO_relaxed.owl GO:1903046 biolink:NamedThing meiotic cell cycle process A process that is part of the meiotic cell cycle. RBO_relaxed.owl GO:0003009 biolink:NamedThing skeletal muscle contraction A process in which force is generated within skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the skeletal muscle, the muscle contraction takes advantage of an ordered sarcomeric structure and in most cases it is under voluntary control. RBO_relaxed.owl GO:0006936 biolink:NamedThing muscle contraction A process in which force is generated within muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. RBO_relaxed.owl GO:0006939 biolink:NamedThing smooth muscle contraction A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Smooth muscle differs from striated muscle in the much higher actin/myosin ratio, the absence of conspicuous sarcomeres and the ability to contract to a much smaller fraction of its resting length. RBO_relaxed.owl GO:0006941 biolink:NamedThing striated muscle contraction A process in which force is generated within striated muscle tissue, resulting in the shortening of the muscle. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Striated muscle is a type of muscle in which the repeating units (sarcomeres) of the contractile myofibrils are arranged in registry throughout the cell, resulting in transverse or oblique striations observable at the level of the light microscope. RBO_relaxed.owl GO:0060048 biolink:NamedThing cardiac muscle contraction Muscle contraction of cardiac muscle tissue. RBO_relaxed.owl GO:0003012 biolink:NamedThing muscle system process A organ system process carried out at the level of a muscle. Muscle tissue is composed of contractile cells or fibers. RBO_relaxed.owl GO:0003013 biolink:NamedThing circulatory system process A organ system process carried out by any of the organs or tissues of the circulatory system. The circulatory system is an organ system that moves extracellular fluids to and from tissue within a multicellular organism. RBO_relaxed.owl GO:0003014 biolink:NamedThing renal system process A organ system process carried out by any of the organs or tissues of the renal system. The renal system maintains fluid balance, and contributes to electrolyte balance, acid/base balance, and disposal of nitrogenous waste products. In humans, the renal system comprises a pair of kidneys, a pair of ureters, urinary bladder, urethra, sphincter muscle and associated blood vessels; in other species, the renal system may comprise related structures (e.g., nephrocytes and malpighian tubules in Drosophila). RBO_relaxed.owl GO:0003016 biolink:NamedThing respiratory system process A process carried out by the organs or tissues of the respiratory system. The respiratory system is an organ system responsible for respiratory gaseous exchange. RBO_relaxed.owl GO:0007588 biolink:NamedThing excretion The elimination by an organism of the waste products that arise as a result of metabolic activity. These products include water, carbon dioxide (CO2), and nitrogenous compounds. RBO_relaxed.owl GO:0050886 biolink:NamedThing endocrine process The process that involves the secretion of or response to endocrine hormones. An endocrine hormone is a hormone released into the circulatory system. RBO_relaxed.owl GO:0061007 biolink:NamedThing hepaticobiliary system process An system process carried out by any of the organs or tissues of the hepaticobiliary system. The hepaticobiliary system is responsible for metabolic and catabolic processing of small molecules absorbed from the blood or gut, hormones and serum proteins, detoxification, storage of glycogen, triglycerides, metals and lipid soluble vitamins and excretion of bile. Included are the synthesis of albumin, blood coagulation factors, complement, and specific binding proteins. RBO_relaxed.owl GO:0003015 biolink:NamedThing heart process A circulatory system process carried out by the heart. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. RBO_relaxed.owl GO:0008015 biolink:NamedThing blood circulation The flow of blood through the body of an animal, enabling the transport of nutrients to the tissues and the removal of waste products. RBO_relaxed.owl GO:0003032 biolink:NamedThing detection of oxygen The series of events in which an oxygen stimulus is received by a cell and converted into a molecular signal. RBO_relaxed.owl GO:0009593 biolink:NamedThing detection of chemical stimulus The series of events in which a chemical stimulus is received by a cell and converted into a molecular signal. RBO_relaxed.owl GO:0050907 biolink:NamedThing detection of chemical stimulus involved in sensory perception The series of events in which a chemical stimulus is received and converted into a molecular signal as part of sensory perception. RBO_relaxed.owl GO:0050968 biolink:NamedThing detection of chemical stimulus involved in sensory perception of pain The series of events involved in the perception of pain in which a chemical stimulus is received and converted into a molecular signal. RBO_relaxed.owl GO:0070482 biolink:NamedThing response to oxygen levels Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of oxygen. RBO_relaxed.owl GO:0003096 biolink:NamedThing renal sodium ion transport The directed movement of sodium ions (Na+) by the renal system. RBO_relaxed.owl GO:0097254 biolink:NamedThing renal tubular secretion The elimination of substances from peritubular capillaries (or surrounding hemolymph in invertebrates) into the renal tubules to be incorporated subsequently into the urine. Substances that are secreted include organic anions, ammonia, potassium and drugs. RBO_relaxed.owl GO:0006814 biolink:NamedThing sodium ion transport The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. RBO_relaxed.owl GO:0035725 biolink:NamedThing sodium ion transmembrane transport A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. RBO_relaxed.owl GO:0003131 biolink:NamedThing mesodermal-endodermal cell signaling Any process that mediates the transfer of information from mesodermal cells to endodermal cells. RBO_relaxed.owl GO:0007267 biolink:NamedThing cell-cell signaling Any process that mediates the transfer of information from one cell to another. This process includes signal transduction in the receiving cell and, where applicable, release of a ligand and any processes that actively facilitate its transport and presentation to the receiving cell. Examples include signaling via soluble ligands, via cell adhesion molecules and via gap junctions. RBO_relaxed.owl GO:0003133 biolink:NamedThing endodermal-mesodermal cell signaling Any process that mediates the transfer of information from endodermal cells to mesodermal cells. RBO_relaxed.owl GO:0045168 biolink:NamedThing cell-cell signaling involved in cell fate commitment Signaling at long or short range between cells that results in the commitment of a cell to a certain fate. RBO_relaxed.owl GO:0060495 biolink:NamedThing cell-cell signaling involved in lung development Any process that mediates the transfer of information from one cell to another and contributes to the progression of the lung, from its initial state to the mature structure. RBO_relaxed.owl GO:0060497 biolink:NamedThing mesenchymal-endodermal cell signaling Any process that mediates the transfer of information between a mesenchymal cell and an endodermal cell. RBO_relaxed.owl GO:0060638 biolink:NamedThing mesenchymal-epithelial cell signaling Any process that mediates the transfer of information from a mesenchymal cell to an epithelial cell where it is received and interpreted. RBO_relaxed.owl GO:0060684 biolink:NamedThing epithelial-mesenchymal cell signaling Any process that results in the transfer of information from an epithelial cell to a mesenchymal cell where it is interpreted. RBO_relaxed.owl GO:0086019 biolink:NamedThing cell-cell signaling involved in cardiac conduction Any process that mediates the transfer of information from one cell to another and contributes to the heart process that regulates cardiac muscle contraction; beginning with the generation of an action potential in the sinoatrial node and ending with regulation of contraction of the myocardium. RBO_relaxed.owl GO:0086029 biolink:NamedThing Purkinje myocyte to ventricular cardiac muscle cell signaling Any process that mediates the transfer of information from a Purkinje myocyte to a ventricular cardiac muscle cell. RBO_relaxed.owl GO:0099156 biolink:NamedThing cell-cell signaling via exosome Cell-cell signaling in which the ligand is carried between cells by an exosome. RBO_relaxed.owl GO:0099536 biolink:NamedThing synaptic signaling Cell-cell signaling to, from or within a synapse. RBO_relaxed.owl GO:0150098 biolink:NamedThing glial cell-neuron signaling Cell-cell signaling that mediates the transfer of information from a glial cell to a neuron. This signaling has been shown to be mediated by various molecules, depending on which glial cells release them, and in which tissues the signaling occurs, e.g. microglial cell-derived nerve growth factor (NGF) in the retina, or microglial cell-derived superoxide ions in the cerebellum. RBO_relaxed.owl GO:0150099 biolink:NamedThing neuron-glial cell signaling Cell-cell signaling that mediates the transfer of information from a neuron to a glial cell. This signaling has been shown to be mediated by various molecules released by different types of neurons, e.g. glutamate, gamma-amino butyric acid (GABA), noradrenaline, acetylcholine, dopamine and adenosine. RBO_relaxed.owl GO:0003145 biolink:NamedThing embryonic heart tube formation via epithelial folding The process that gives rise to the embryonic heart tube by the cells of the heart field along a linear axis. RBO_relaxed.owl GO:0003245 biolink:NamedThing cardiac muscle tissue growth involved in heart morphogenesis The developmental growth of cardiac muscle tissue that contributes to the shaping of the heart. RBO_relaxed.owl GO:0003275 biolink:NamedThing apoptotic process involved in outflow tract morphogenesis Any apoptotic process that contributes to the shaping of the outflow tract. The outflow tract is the portion of the heart through which blood flows into the arteries. RBO_relaxed.owl GO:0003278 biolink:NamedThing apoptotic process involved in heart morphogenesis Any apoptotic process that contributes to the shaping of the heart. RBO_relaxed.owl GO:0003277 biolink:NamedThing apoptotic process involved in endocardial cushion morphogenesis Any apoptotic process that contributes to the shaping of an endocardial cushion. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves. RBO_relaxed.owl GO:0006915 biolink:NamedThing apoptotic process A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died. RBO_relaxed.owl GO:0010657 biolink:NamedThing muscle cell apoptotic process A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle a muscle cell and result in its death. A muscle cell is a mature contractile cell, commonly known as a myocyte, that forms one of three kinds of muscle. RBO_relaxed.owl GO:0010658 biolink:NamedThing striated muscle cell apoptotic process A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle a striated muscle cell and result in its death. Striated muscle cells make up striated muscle fibers which are divided by transverse bands into striations. RBO_relaxed.owl GO:0010659 biolink:NamedThing cardiac muscle cell apoptotic process A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle a cardiac muscle cell and result in its death. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. RBO_relaxed.owl GO:0033028 biolink:NamedThing myeloid cell apoptotic process Any apoptotic process in a myeloid cell, a cell of the monocyte, granulocyte, mast cell, megakaryocyte, or erythroid lineage. RBO_relaxed.owl GO:0034349 biolink:NamedThing glial cell apoptotic process Any apoptotic process in a glial cell, a non-neuronal cell of the nervous system. RBO_relaxed.owl GO:0034390 biolink:NamedThing smooth muscle cell apoptotic process Any apoptotic process in a smooth muscle cell. Smooth muscle consists of non-striated, elongated, spindle-shaped cell found lining the digestive tract, uterus, and blood vessels. RBO_relaxed.owl GO:0044346 biolink:NamedThing fibroblast apoptotic process Any apoptotic process in a fibroblast, a connective tissue cell which secretes an extracellular matrix rich in collagen and other macromolecules. RBO_relaxed.owl GO:0051402 biolink:NamedThing neuron apoptotic process Any apoptotic process in a neuron, the basic cellular unit of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system. RBO_relaxed.owl GO:0060561 biolink:NamedThing apoptotic process involved in morphogenesis Any apoptotic process that contributes to the shaping of an anatomical structure. RBO_relaxed.owl GO:0071887 biolink:NamedThing leukocyte apoptotic process Any apoptotic process in a leukocyte, an achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue. RBO_relaxed.owl GO:0072577 biolink:NamedThing endothelial cell apoptotic process Any apoptotic process in an endothelial cell. An endothelial cell comprises the outermost layer or lining of anatomical structures and can be squamous or cuboidal. RBO_relaxed.owl GO:0097049 biolink:NamedThing motor neuron apoptotic process Any apoptotic process in a motor neuron, an efferent neuron that passes from the central nervous system or a ganglion toward or to a muscle and conducts an impulse that causes movement. RBO_relaxed.owl GO:0097050 biolink:NamedThing type B pancreatic cell apoptotic process Any apoptotic process in a type B pancreatic cell, a cell located towards center of the islets of Langerhans that secretes insulin. RBO_relaxed.owl GO:0097152 biolink:NamedThing mesenchymal cell apoptotic process Any apoptotic process in a mesenchymal cell. A mesenchymal cell is a loosely associated cell that is part of the connective tissue in an organism. Mesenchymal cells give rise to more mature connective tissue cell types. RBO_relaxed.owl GO:0097284 biolink:NamedThing hepatocyte apoptotic process Any apoptotic process in a hepatocyte, the main structural component of the liver. RBO_relaxed.owl GO:0097473 biolink:NamedThing retinal rod cell apoptotic process Any apoptotic process in a retinal rod cell, one of the two photoreceptor cell types of the vertebrate retina. RBO_relaxed.owl GO:0097474 biolink:NamedThing retinal cone cell apoptotic process Any apoptotic process in a retinal cone cell, one of the two photoreceptor cell types of the vertebrate retina. RBO_relaxed.owl GO:1902217 biolink:NamedThing erythrocyte apoptotic process Any apoptotic process in an erythrocyte. RBO_relaxed.owl GO:1902262 biolink:NamedThing apoptotic process involved in blood vessel morphogenesis Any apoptotic process that is involved in blood vessel morphogenesis. RBO_relaxed.owl GO:1902488 biolink:NamedThing cholangiocyte apoptotic process Any apoptotic process in a cholangiocyte. RBO_relaxed.owl GO:1902489 biolink:NamedThing hepatoblast apoptotic process Any apoptotic process in a hepatoblast. RBO_relaxed.owl GO:1902742 biolink:NamedThing apoptotic process involved in development Any apoptotic process that is involved in anatomical structure development. RBO_relaxed.owl GO:1904019 biolink:NamedThing epithelial cell apoptotic process Any apoptotic process in an epithelial cell. RBO_relaxed.owl GO:1904606 biolink:NamedThing fat cell apoptotic process Any apoptotic process in a fat cell. RBO_relaxed.owl GO:1905288 biolink:NamedThing vascular associated smooth muscle cell apoptotic process Any apoptotic process in a vascular associated smooth muscle cell. RBO_relaxed.owl GO:1990009 biolink:NamedThing retinal cell apoptotic process Any apoptotic process in a retinal cell. RBO_relaxed.owl GO:1990010 biolink:NamedThing compound eye retinal cell apoptotic process Any apoptotic process in a compound eye retinal cell. RBO_relaxed.owl GO:0061307 biolink:NamedThing cardiac neural crest cell differentiation involved in heart development The process in which a relatively unspecialized cell acquires specialized features of a cardiac neural crest cell that will migrate to the heart and contribute to its development. Cardiac neural crest cells are specialized cells that migrate toward the heart from the third, fourth and sixth pharyngeal arches. RBO_relaxed.owl GO:0003298 biolink:NamedThing physiological muscle hypertrophy The enlargement or overgrowth of all or part of a muscle organ or tissue due to an increase in the size of its muscle cells. Physiological hypertrophy is a normal process during development. RBO_relaxed.owl GO:0014896 biolink:NamedThing muscle hypertrophy The muscle system process that results in enlargement or overgrowth of all or part of a muscle organ due to an increase in the size of its muscle cells. Physiological hypertrophy is a normal process during development (it stops in cardiac muscle after adolescence) and can also be brought on in response to demand. In athletes cardiac and skeletal muscles undergo hypertrophy stimulated by increasing muscle activity on exercise. Smooth muscle cells in the uterus undergo hypertrophy during pregnancy. RBO_relaxed.owl GO:0014734 biolink:NamedThing skeletal muscle hypertrophy The enlargement or overgrowth of all or part of an organ due to an increase in size (not length) of individual muscle fibers without cell division. In the case of skeletal muscle cells this happens due to the additional synthesis of sarcomeric proteins and assembly of myofibrils. RBO_relaxed.owl GO:0014895 biolink:NamedThing smooth muscle hypertrophy The enlargement or overgrowth of all or part of an organ due to an increase in size of its smooth muscle cells without cell division. Physiological hypertrophy is a normal process during development, and can also occur in mature structures on demand. In the uterus, smooth muscle cells undergo hypertrophy during pregnancy. RBO_relaxed.owl GO:0014897 biolink:NamedThing striated muscle hypertrophy The enlargement or overgrowth of all or part of an organ due to an increase in size of muscle cells without cell division. In the case of striated muscle, this happens due to the additional synthesis of sarcomeric proteins and assembly of myofibrils. RBO_relaxed.owl GO:0003300 biolink:NamedThing cardiac muscle hypertrophy The enlargement or overgrowth of all or part of the heart muscle due to an increase in size of cardiac muscle cells without cell division. RBO_relaxed.owl GO:0003301 biolink:NamedThing physiological cardiac muscle hypertrophy The enlargement or overgrowth of all or part of the heart muscle due to an increase in size of cardiac muscle cells without cell division. This process contributes to the developmental growth of the heart. RBO_relaxed.owl GO:0003333 biolink:NamedThing amino acid transmembrane transport The process in which an amino acid is transported across a membrane. RBO_relaxed.owl GO:0006810 biolink:NamedThing transport The directed movement of substances (such as macromolecules, small molecules, ions) or cellular components (such as complexes and organelles) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or a transporter complex, a pore or a motor protein. RBO_relaxed.owl GO:0006811 biolink:NamedThing monoatomic ion transport The directed movement of a monoatomic ion into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Monatomic ions (also called simple ions) are ions consisting of exactly one atom. RBO_relaxed.owl GO:0006812 biolink:NamedThing monoatomic cation transport The directed movement of a monoatomic cation, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Monatomic cations (also called simple cations) are positively charged ions consisting of exactly one atom. RBO_relaxed.owl GO:0006817 biolink:NamedThing phosphate ion transport The directed movement of phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. RBO_relaxed.owl GO:0006835 biolink:NamedThing dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. RBO_relaxed.owl GO:0006836 biolink:NamedThing neurotransmitter transport The directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell. RBO_relaxed.owl GO:0006846 biolink:NamedThing acetate transport The directed movement of acetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. RBO_relaxed.owl GO:0006847 biolink:NamedThing plasma membrane acetate transport The directed movement of acetate across a plasma membrane. RBO_relaxed.owl GO:0006858 biolink:NamedThing extracellular transport The transport of substances that occurs outside cells. RBO_relaxed.owl GO:0006865 biolink:NamedThing amino acid transport The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. RBO_relaxed.owl GO:0006869 biolink:NamedThing lipid transport The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. RBO_relaxed.owl GO:0006886 biolink:NamedThing intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. RBO_relaxed.owl GO:0006887 biolink:NamedThing exocytosis A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle. Exocytosis can occur either by full fusion, when the vesicle collapses into the plasma membrane, or by a kiss-and-run mechanism that involves the formation of a transient contact, a pore, between a granule (for exemple of chromaffin cells) and the plasma membrane. The latter process most of the time leads to only partial secretion of the granule content. Exocytosis begins with steps that prepare vesicles for fusion with the membrane (tethering and docking) and ends when molecules are secreted from the cell. RBO_relaxed.owl GO:0008272 biolink:NamedThing sulfate transport The directed movement of sulfate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. RBO_relaxed.owl GO:0008643 biolink:NamedThing carbohydrate transport The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are a group of organic compounds based of the general formula Cx(H2O)y. RBO_relaxed.owl GO:0008645 biolink:NamedThing hexose transmembrane transport The process in which hexose is transported across a membrane. Hexoses are aldoses with a chain of six carbon atoms in the molecule. RBO_relaxed.owl GO:0009914 biolink:NamedThing hormone transport The directed movement of hormones into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. RBO_relaxed.owl GO:0010496 biolink:NamedThing intercellular transport The movement of substances between cells. RBO_relaxed.owl GO:0010970 biolink:NamedThing transport along microtubule The movement of organelles or other particles from one location in the cell to another along microtubules, driven by motor activity. RBO_relaxed.owl GO:0015031 biolink:NamedThing protein transport The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. RBO_relaxed.owl GO:0015669 biolink:NamedThing gas transport The directed movement of substances that are gaseous in normal living conditions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. RBO_relaxed.owl GO:0015671 biolink:NamedThing oxygen transport The directed movement of oxygen (O2) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. RBO_relaxed.owl GO:0015695 biolink:NamedThing organic cation transport The directed movement of organic cations into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Organic cations are atoms or small molecules with a positive charge which contain carbon in covalent linkage. RBO_relaxed.owl GO:0015698 biolink:NamedThing inorganic anion transport The directed movement of inorganic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Inorganic anions are atoms or small molecules with a negative charge which do not contain carbon in covalent linkage. RBO_relaxed.owl GO:0015701 biolink:NamedThing bicarbonate transport The directed movement of bicarbonate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. RBO_relaxed.owl GO:0015711 biolink:NamedThing organic anion transport The directed movement of organic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage. RBO_relaxed.owl GO:0015718 biolink:NamedThing monocarboxylic acid transport The directed movement of monocarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. RBO_relaxed.owl GO:0015721 biolink:NamedThing bile acid and bile salt transport The directed movement of bile acid and bile salts into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. RBO_relaxed.owl GO:0015723 biolink:NamedThing bilirubin transport The directed movement of bilirubin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. RBO_relaxed.owl GO:0015749 biolink:NamedThing monosaccharide transmembrane transport The process in which a monosaccharide is transported across a lipid bilayer, from one side of a membrane to the other. Monosaccharides are the simplest carbohydrates; they are polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides. RBO_relaxed.owl GO:0015774 biolink:NamedThing polysaccharide transport The directed movement of polysaccharides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A polysaccharide is a polymer of many (typically more than 10) monosaccharide residues linked glycosidically. RBO_relaxed.owl GO:0015837 biolink:NamedThing amine transport The directed movement of amines, including polyamines, organic compounds containing one or more amino groups, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. RBO_relaxed.owl GO:0015844 biolink:NamedThing monoamine transport The directed movement of monoamines, organic compounds that contain one amino group that is connected to an aromatic ring by an ethylene group (-CH2-CH2-), into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. RBO_relaxed.owl GO:0015849 biolink:NamedThing organic acid transport The directed movement of organic acids, any acidic compound containing carbon in covalent linkage, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. RBO_relaxed.owl GO:0015850 biolink:NamedThing organic hydroxy compound transport The directed movement of an organic hydroxy compound (organic alcohol) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. An organic hydroxy compound is an organic compound having at least one hydroxy group attached to a carbon atom. RBO_relaxed.owl GO:0015851 biolink:NamedThing nucleobase transport The directed movement of a nucleobase, any nitrogenous base that is a constituent of a nucleoside, nucleotide, or nucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. RBO_relaxed.owl GO:0015869 biolink:NamedThing protein-DNA complex transport The directed movement of protein-DNA complexes into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. RBO_relaxed.owl GO:0015870 biolink:NamedThing acetylcholine transport The directed movement of acetylcholine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Acetylcholine is an acetic acid ester of the organic base choline and functions as a neurotransmitter, released at the synapses of parasympathetic nerves and at neuromuscular junctions. RBO_relaxed.owl GO:0015874 biolink:NamedThing norepinephrine transport The directed movement of norepinephrine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Norepinephrine (3,4-dihydroxyphenyl-2-aminoethanol) is a hormone secreted by the adrenal medulla and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS. It is also the biosynthetic precursor of epinephrine. RBO_relaxed.owl GO:0015931 biolink:NamedThing nucleobase-containing compound transport The directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. RBO_relaxed.owl GO:0016192 biolink:NamedThing vesicle-mediated transport A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane. RBO_relaxed.owl GO:0019755 biolink:NamedThing one-carbon compound transport The directed movement of one-carbon compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. RBO_relaxed.owl GO:0030001 biolink:NamedThing metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. RBO_relaxed.owl GO:0032365 biolink:NamedThing intracellular lipid transport The directed movement of lipids within cells. RBO_relaxed.owl GO:0034219 biolink:NamedThing carbohydrate transmembrane transport The process in which a carbohydrate is transported across a membrane. RBO_relaxed.owl GO:0034220 biolink:NamedThing monoatomic ion transmembrane transport A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom. RBO_relaxed.owl GO:0034436 biolink:NamedThing glycoprotein transport The directed movement of a glycoprotein, a protein that contains covalently bound glycose (i.e. monosaccharide) residues, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. RBO_relaxed.owl GO:0034486 biolink:NamedThing vacuolar transmembrane transport The process in which a solute is transported from one side of the vacuolar membrane to the other. RBO_relaxed.owl GO:0034487 biolink:NamedThing vacuolar amino acid transmembrane transport The process in which an amino acid is transported from one side of the vacuolar membrane to the other. RBO_relaxed.owl GO:0035433 biolink:NamedThing acetate transmembrane transport The process in which acetate is transported across a membrane. Acetate is the 2-carbon carboxylic acid ethanoic acid. RBO_relaxed.owl GO:0035435 biolink:NamedThing phosphate ion transmembrane transport The process in which a phosphate is transported across a membrane. RBO_relaxed.owl GO:0042073 biolink:NamedThing intraciliary transport The bidirectional movement of large protein complexes along microtubules within a cilium, mediated by motor proteins. RBO_relaxed.owl GO:0042886 biolink:NamedThing amide transport The directed movement of an amide, any compound containing one, two, or three acyl groups attached to a nitrogen atom, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. RBO_relaxed.owl GO:0046907 biolink:NamedThing intracellular transport The directed movement of substances within a cell. RBO_relaxed.owl GO:0046942 biolink:NamedThing carboxylic acid transport The directed movement of carboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carboxylic acids are organic acids containing one or more carboxyl (COOH) groups or anions (COO-). RBO_relaxed.owl GO:0047496 biolink:NamedThing vesicle transport along microtubule The directed movement of a vesicle along a microtubule, mediated by motor proteins. This process begins with the attachment of a vesicle to a microtubule, and ends when the vesicle reaches its final destination. RBO_relaxed.owl GO:0048193 biolink:NamedThing Golgi vesicle transport The directed movement of substances into, out of or within the Golgi apparatus, mediated by vesicles. RBO_relaxed.owl GO:0050657 biolink:NamedThing nucleic acid transport The directed movement of nucleic acids, single or double-stranded polynucleotides involved in the storage, transmission and transfer of genetic information, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. RBO_relaxed.owl GO:0050658 biolink:NamedThing RNA transport The directed movement of RNA, ribonucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. RBO_relaxed.owl GO:0051027 biolink:NamedThing DNA transport The directed movement of RNA, deoxyribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. RBO_relaxed.owl GO:0051169 biolink:NamedThing nuclear transport The directed movement of substances into, out of, or within the nucleus. RBO_relaxed.owl GO:0051620 biolink:NamedThing norepinephrine uptake The directed movement of norepinephrine into a cell, typically presynaptic neurons or glial cells. Norepinephrine (3,4-dihydroxyphenyl-2-aminoethanol) is a hormone secreted by the adrenal medulla and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS. It is also the biosynthetic precursor of epinephrine. RBO_relaxed.owl GO:0051630 biolink:NamedThing acetylcholine uptake The directed movement of acetylcholine into a cell, typically presynaptic neurons or glial cells. Acetylcholine is a major neurotransmitter and neuromodulator both in the central and peripheral nervous systems. It also acts as a paracrine signal in various non-neural tissues. RBO_relaxed.owl GO:0051904 biolink:NamedThing pigment granule transport The directed movement of pigment granules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. RBO_relaxed.owl GO:0051937 biolink:NamedThing catecholamine transport The directed movement of catecholamines, a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine. RBO_relaxed.owl GO:0055085 biolink:NamedThing transmembrane transport The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. RBO_relaxed.owl GO:0055107 biolink:NamedThing Golgi to secretory granule transport The directed movement of proteins from the Golgi to a secretory granule. The secretory granule is a membrane-bounded particle, usually protein, formed in the granular endoplasmic reticulum and the Golgi complex. RBO_relaxed.owl GO:0055108 biolink:NamedThing Golgi to transport vesicle transport The directed movement of proteins from the Golgi to a transport vesicle. Continuously secreted proteins are sorted into transport vesicles that fuse with the plasma membrane, releasing their contents by exocytosis. RBO_relaxed.owl GO:0065002 biolink:NamedThing intracellular protein transmembrane transport The directed movement of proteins in a cell, from one side of a membrane to another by means of some agent such as a transporter or pore. RBO_relaxed.owl GO:0070633 biolink:NamedThing transepithelial transport The directed movement of a substance from one side of an epithelium to the other. RBO_relaxed.owl GO:0071702 biolink:NamedThing organic substance transport The directed movement of organic substances into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore. An organic substance is a molecular entity that contains carbon. RBO_relaxed.owl GO:0071705 biolink:NamedThing nitrogen compound transport The directed movement of nitrogen-containing compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. RBO_relaxed.owl GO:0071806 biolink:NamedThing protein transmembrane transport The process in which a protein is transported across a membrane. RBO_relaxed.owl GO:0072348 biolink:NamedThing sulfur compound transport The directed movement of compounds that contain sulfur, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. RBO_relaxed.owl GO:0072488 biolink:NamedThing ammonium transmembrane transport The process in which ammonium is transported across a membrane. Ammonium is the cation NH4+. RBO_relaxed.owl GO:0090493 biolink:NamedThing catecholamine uptake The directed movement of catecholamine into a cell. RBO_relaxed.owl GO:0098655 biolink:NamedThing monoatomic cation transmembrane transport The process in which a monoatomic cation is transported across a membrane. Monatomic cations (also called simple cations) are positively charged ions consisting of exactly one atom. RBO_relaxed.owl GO:0098657 biolink:NamedThing import into cell The directed movement of some substance from outside of a cell into a cell. This may occur via transport across the plasma membrane or via endocytosis. RBO_relaxed.owl GO:0098660 biolink:NamedThing inorganic ion transmembrane transport The process in which an inorganic ion is transported across a membrane. RBO_relaxed.owl GO:0098661 biolink:NamedThing inorganic anion transmembrane transport The process in which an inorganic anion is transported across a membrane. RBO_relaxed.owl GO:0098662 biolink:NamedThing inorganic cation transmembrane transport A process in which an inorganic cation is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. RBO_relaxed.owl GO:0098876 biolink:NamedThing vesicle-mediated transport to the plasma membrane The directed movement of substances to the plasma membrane in transport vesicles that fuse with the plasma membrane by exocytosis. RBO_relaxed.owl GO:0099111 biolink:NamedThing microtubule-based transport A microtubule-based process that results in the transport of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules. RBO_relaxed.owl GO:0099632 biolink:NamedThing protein transport within plasma membrane A process in which protein is transported from one region of the plasma membrane to another. RBO_relaxed.owl GO:0140352 biolink:NamedThing export from cell The directed movement of some substance from a cell, into the extracellular region. This may occur via transport across the plasma membrane or via exocytosis. RBO_relaxed.owl GO:0140353 biolink:NamedThing lipid export from cell The directed movement of a lipid from a cell, into the extracellular region. RBO_relaxed.owl GO:0140354 biolink:NamedThing lipid import into cell The directed movement of a lipid from outside of a cell into a cell. This may occur via transport across the plasma membrane or via endocytosis. RBO_relaxed.owl GO:1901264 biolink:NamedThing carbohydrate derivative transport The directed movement of a carbohydrate derivative into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. RBO_relaxed.owl GO:1901374 biolink:NamedThing acetate ester transport The directed movement of an acetate ester into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. RBO_relaxed.owl GO:1903825 biolink:NamedThing organic acid transmembrane transport The process in which an organic acid is transported across a membrane. RBO_relaxed.owl GO:1904659 biolink:NamedThing glucose transmembrane transport The process in which glucose is transported across a membrane. RBO_relaxed.owl GO:1905039 biolink:NamedThing carboxylic acid transmembrane transport The process in which carboxylic acid is transported across a membrane. RBO_relaxed.owl GO:0006860 biolink:NamedThing extracellular amino acid transport The directed extracellular movement of amino acids. RBO_relaxed.owl GO:0003361 biolink:NamedThing noradrenergic neuron differentiation involved in brainstem development The process in which a relatively unspecialized cell acquires specialized features of an noradrenergic neuron that is part of the brainstem. RBO_relaxed.owl GO:0003365 biolink:NamedThing establishment of cell polarity involved in ameboidal cell migration The specification and formation of anisotropic intracellular organization that contributes to the self-propelled directed movement of an ameboid cell. RBO_relaxed.owl GO:0030010 biolink:NamedThing establishment of cell polarity The specification and formation of anisotropic intracellular organization or cell growth patterns. RBO_relaxed.owl GO:0003379 biolink:NamedThing establishment of cell polarity involved in gastrulation cell migration The specification and formation of anisotropic intracellular organization that contributes to the self-propelled directed movement of an ameboid cell taking part in gastrulation. RBO_relaxed.owl GO:0045200 biolink:NamedThing establishment of neuroblast polarity The specification and formation of the apicobasal polarity of a neuroblast cell, a progenitor of the central nervous system. RBO_relaxed.owl GO:0090162 biolink:NamedThing establishment of epithelial cell polarity The specification and formation of anisotropic intracellular organization of an epithelial cell. RBO_relaxed.owl GO:0003371 biolink:NamedThing establishment or maintenance of cytoskeleton polarity involved in ameboidal cell migration Any cellular process that results in the specification, formation or maintenance of polarized cytoskeletal structures that contribute to the cell polarity of a migrating ameboid cell. RBO_relaxed.owl GO:0003380 biolink:NamedThing establishment or maintenance of cytoskeleton polarity involved in gastrulation Any cellular process that results in the specification, formation or maintenance of polarized cytoskeletal structures that contribute to the cell polarity of a migrating ameboid cell taking part in gastrulation. RBO_relaxed.owl GO:0003411 biolink:NamedThing cell motility involved in camera-type eye morphogenesis Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another and contributes to the physical shaping or formation of the camera-type eye. RBO_relaxed.owl GO:0048870 biolink:NamedThing cell motility Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another. RBO_relaxed.owl GO:0003413 biolink:NamedThing chondrocyte differentiation involved in endochondral bone morphogenesis The process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte that will contribute to the development of a bone. A chondrocyte is a polymorphic cell that forms cartilage. RBO_relaxed.owl GO:0003414 biolink:NamedThing chondrocyte morphogenesis involved in endochondral bone morphogenesis The process in which the structures of a chondrocyte that will contribute to bone development are generated and organized. RBO_relaxed.owl GO:0003433 biolink:NamedThing chondrocyte development involved in endochondral bone morphogenesis The progression of a chondrocyte over time from after its commitment to its mature state where the chondrocyte will contribute to the shaping of an endochondral bone. RBO_relaxed.owl GO:0003824 biolink:NamedThing catalytic activity Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. RBO_relaxed.owl GO:0005215 biolink:NamedThing transporter activity Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells. RBO_relaxed.owl GO:0004518 biolink:NamedThing nuclease activity Catalysis of the hydrolysis of ester linkages within nucleic acids. RBO_relaxed.owl GO:0016788 biolink:NamedThing hydrolase activity, acting on ester bonds Catalysis of the hydrolysis of any ester bond. RBO_relaxed.owl GO:0004536 biolink:NamedThing DNA nuclease activity Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid. RBO_relaxed.owl GO:0140097 biolink:NamedThing catalytic activity, acting on DNA Catalytic activity that acts to modify DNA. RBO_relaxed.owl GO:0005275 biolink:NamedThing amine transmembrane transporter activity Enables the transfer of amines, including polyamines, from one side of a membrane to the other. Amines are organic compounds that are weakly basic in character and contain an amino (-NH2) or substituted amino group. RBO_relaxed.owl GO:0022857 biolink:NamedThing transmembrane transporter activity Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. RBO_relaxed.owl GO:0005277 biolink:NamedThing acetylcholine transmembrane transporter activity Enables the transfer of acetylcholine from one side of a membrane to the other. Acetylcholine is an acetic acid ester of the organic base choline and functions as a neurotransmitter, released at the synapses of parasympathetic nerves and at neuromuscular junctions. RBO_relaxed.owl GO:0005310 biolink:NamedThing dicarboxylic acid transmembrane transporter activity Enables the transfer of dicarboxylic acids from one side of a membrane to the other. A dicarboxylic acid is an organic acid with two COOH groups. RBO_relaxed.owl GO:0005342 biolink:NamedThing organic acid transmembrane transporter activity Enables the transfer of organic acids from one side of a membrane to the other. Organic acids are acidic compound containing carbon in covalent linkage. RBO_relaxed.owl GO:0005355 biolink:NamedThing glucose transmembrane transporter activity Enables the transfer of the hexose monosaccharide glucose from one side of a membrane to the other. RBO_relaxed.owl GO:0008028 biolink:NamedThing monocarboxylic acid transmembrane transporter activity Enables the transfer of monocarboxylic acids from one side of a membrane to the other. A monocarboxylic acid is an organic acid with one COOH group. RBO_relaxed.owl GO:0008324 biolink:NamedThing monoatomic cation transmembrane transporter activity Enables the transfer of cation from one side of a membrane to the other. RBO_relaxed.owl GO:0008504 biolink:NamedThing monoamine transmembrane transporter activity Enables the transfer of monoamines, organic compounds that contain one amino group that is connected to an aromatic ring by an ethylene group (-CH2-CH2-), from one side of a membrane to the other. RBO_relaxed.owl GO:0008514 biolink:NamedThing organic anion transmembrane transporter activity Enables the transfer of organic anions from one side of a membrane to the other. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage. RBO_relaxed.owl GO:0015075 biolink:NamedThing monoatomic ion transmembrane transporter activity Enables the transfer of an ion from one side of a membrane to the other. RBO_relaxed.owl GO:0015081 biolink:NamedThing sodium ion transmembrane transporter activity Enables the transfer of sodium ions (Na+) from one side of a membrane to the other. RBO_relaxed.owl GO:0015101 biolink:NamedThing organic cation transmembrane transporter activity Enables the transfer of organic cations from one side of a membrane to the other. Organic cations are atoms or small molecules with a positive charge that contain carbon in covalent linkage. RBO_relaxed.owl GO:0015103 biolink:NamedThing inorganic anion transmembrane transporter activity Enables the transfer of inorganic anions from one side of a membrane to the other. Inorganic anions are atoms or small molecules with a negative charge which do not contain carbon in covalent linkage. RBO_relaxed.owl GO:0015106 biolink:NamedThing bicarbonate transmembrane transporter activity Enables the transfer of bicarbonate from one side of a membrane to the other. Bicarbonate is the hydrogencarbonate ion, HCO3-. RBO_relaxed.owl GO:0015114 biolink:NamedThing phosphate ion transmembrane transporter activity Enables the transfer of phosphate (PO4 3-) ions from one side of a membrane to the other. RBO_relaxed.owl GO:0015116 biolink:NamedThing sulfate transmembrane transporter activity Enables the transfer of sulfate ions, SO4(2-), from one side of a membrane to the other. RBO_relaxed.owl GO:0015123 biolink:NamedThing acetate transmembrane transporter activity Enables the transfer of acetate from one side of a membrane to the other. Acetate is the 2-carbon carboxylic acid ethanoic acid. RBO_relaxed.owl GO:0015125 biolink:NamedThing bile acid transmembrane transporter activity Enables the transfer of bile acid from one side of a membrane to the other. Bile acids are any of a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine. RBO_relaxed.owl GO:0015127 biolink:NamedThing bilirubin transmembrane transporter activity Enables the transfer of bilirubin from one side of a membrane to the other. Bilirubin is a linear tetrapyrrole produced in the reticuloendothelial system from biliverdin and transported to the liver as a complex with serum albumin. In the liver, bilirubin is converted to bilirubin bisglucuronide, which is excreted in the bile. RBO_relaxed.owl GO:0015144 biolink:NamedThing carbohydrate transmembrane transporter activity Enables the transfer of carbohydrate from one side of a membrane to the other. RBO_relaxed.owl GO:0015145 biolink:NamedThing monosaccharide transmembrane transporter activity Enables the transfer of a monosaccharide from one side of a membrane to the other. RBO_relaxed.owl GO:0015149 biolink:NamedThing hexose transmembrane transporter activity Enables the transfer of a hexose sugar, a monosaccharide with 6 carbon atoms, from one side of a membrane to the other. RBO_relaxed.owl GO:0015159 biolink:NamedThing polysaccharide transmembrane transporter activity Enables the transfer of polysaccharides from one side of a membrane to the other. A polysaccharide is a polymer of many (typically more than 10) monosaccharide residues linked glycosidically. RBO_relaxed.owl GO:0015171 biolink:NamedThing amino acid transmembrane transporter activity Enables the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group. RBO_relaxed.owl GO:0015205 biolink:NamedThing nucleobase transmembrane transporter activity Enables the transfer of a nucleobase, any nitrogenous base that is a constituent of a nucleoside, nucleotide, or nucleic acidfrom one side of a membrane to the other. RBO_relaxed.owl GO:0015318 biolink:NamedThing inorganic molecular entity transmembrane transporter activity Enables the transfer of an inorganic molecular entity from the outside of a cell to the inside of the cell across a membrane. An inorganic molecular entity is a molecular entity that contains no carbon. RBO_relaxed.owl GO:0015932 biolink:NamedThing nucleobase-containing compound transmembrane transporter activity Enables the transfer of nucleobases, nucleosides, nucleotides and nucleic acids from one side of a membrane to the other. RBO_relaxed.owl GO:0022804 biolink:NamedThing active transmembrane transporter activity Enables the transfer of a specific substance or related group of substances from one side of a membrane to the other, up the solute's concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction. RBO_relaxed.owl GO:0022884 biolink:NamedThing macromolecule transmembrane transporter activity Enables the transfer of a macromolecule from one side of a membrane to the other. RBO_relaxed.owl GO:0022890 biolink:NamedThing inorganic cation transmembrane transporter activity Enables the transfer of inorganic cations from one side of a membrane to the other. Inorganic cations are atoms or small molecules with a positive charge that do not contain carbon in covalent linkage. RBO_relaxed.owl GO:0042887 biolink:NamedThing amide transmembrane transporter activity Enables the transfer of an amide, any compound containing one, two, or three acyl groups attached to a nitrogen atom, from one side of a membrane to the other. RBO_relaxed.owl GO:0046873 biolink:NamedThing metal ion transmembrane transporter activity Enables the transfer of metal ions from one side of a membrane to the other. RBO_relaxed.owl GO:0046943 biolink:NamedThing carboxylic acid transmembrane transporter activity Enables the transfer of carboxylic acids from one side of a membrane to the other. Carboxylic acids are organic acids containing one or more carboxyl (COOH) groups or anions (COO-). RBO_relaxed.owl GO:0051032 biolink:NamedThing nucleic acid transmembrane transporter activity Enables the transfer of nucleic acids from one side of a membrane to the other. Nucleic acids are single or double-stranded polynucleotides involved in the storage, transmission and transfer of genetic information. RBO_relaxed.owl GO:0051033 biolink:NamedThing RNA transmembrane transporter activity Enables the transfer of RNA, ribonucleic acid, from one side of a membrane to the other. RBO_relaxed.owl GO:0051035 biolink:NamedThing DNA transmembrane transporter activity Enables the transfer of DNA, deoxyribonucleic acid, from one side of a membrane to the other. RBO_relaxed.owl GO:1901375 biolink:NamedThing acetate ester transmembrane transporter activity Enables the transfer of an acetate ester from one side of a membrane to the other. RBO_relaxed.owl GO:1901505 biolink:NamedThing carbohydrate derivative transmembrane transporter activity Enables the transfer of carbohydrate derivative from one side of a membrane to the other. RBO_relaxed.owl GO:1901618 biolink:NamedThing organic hydroxy compound transmembrane transporter activity Enables the transfer of organic hydroxy compound from one side of a membrane to the other. RBO_relaxed.owl GO:1901682 biolink:NamedThing sulfur compound transmembrane transporter activity Enables the transfer of a sulfur compound from one side of a membrane to the other. RBO_relaxed.owl GO:1901702 biolink:NamedThing salt transmembrane transporter activity Enables the transfer of salt from one side of a membrane to the other. RBO_relaxed.owl GO:0005326 biolink:NamedThing neurotransmitter transmembrane transporter activity Enables the directed movement of a neurotransmitter into, out of or within a cell, or between cells. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell. RBO_relaxed.owl GO:0005319 biolink:NamedThing lipid transporter activity Enables the directed movement of lipids into, out of or within a cell, or between cells. RBO_relaxed.owl GO:0008320 biolink:NamedThing protein transmembrane transporter activity Enables the transfer of a protein from one side of a membrane to the other. RBO_relaxed.owl GO:0140318 biolink:NamedThing protein transporter activity Directly binding to a specific protein and delivering it to a specific cellular location. RBO_relaxed.owl GO:1904680 biolink:NamedThing peptide transmembrane transporter activity Enables the transfer of a peptide from one side of a membrane to the other. RBO_relaxed.owl GO:0005576 biolink:NamedThing extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. RBO_relaxed.owl GO:0005615 biolink:NamedThing extracellular space That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. RBO_relaxed.owl GO:0005622 biolink:NamedThing intracellular anatomical structure A component of a cell contained within (but not including) the plasma membrane. In eukaryotes it includes the nucleus and cytoplasm. RBO_relaxed.owl GO:0005930 biolink:NamedThing axoneme The bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements. RBO_relaxed.owl GO:0012505 biolink:NamedThing endomembrane system A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles. RBO_relaxed.owl GO:0030054 biolink:NamedThing cell junction A cellular component that forms a specialized region of connection between two or more cells, or between a cell and the extracellular matrix, or between two membrane-bound components of a cell, such as flagella. RBO_relaxed.owl GO:0030312 biolink:NamedThing external encapsulating structure A structure that lies outside the plasma membrane and surrounds the entire cell or cells. This does not include the periplasmic space. RBO_relaxed.owl GO:0031252 biolink:NamedThing cell leading edge The area of a motile cell closest to the direction of movement. RBO_relaxed.owl GO:0031256 biolink:NamedThing leading edge membrane The portion of the plasma membrane surrounding the leading edge of a motile cell. RBO_relaxed.owl GO:0031974 biolink:NamedThing membrane-enclosed lumen The enclosed volume within a sealed membrane or between two sealed membranes. Encompasses the volume enclosed by the membranes of a particular organelle, e.g. endoplasmic reticulum lumen, or the space between the two lipid bilayers of a double membrane surrounding an organelle, e.g. nuclear envelope lumen. RBO_relaxed.owl GO:0031975 biolink:NamedThing envelope A multilayered structure surrounding all or part of a cell; encompasses one or more lipid bilayers, and may include a cell wall layer; also includes the space between layers. RBO_relaxed.owl GO:0032432 biolink:NamedThing actin filament bundle An assembly of actin filaments that are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness. RBO_relaxed.owl GO:0035869 biolink:NamedThing ciliary transition zone A region of the cilium between the basal body and proximal segment that is characterized by Y-shaped assemblages that connect axonemal microtubules to the ciliary membrane. The ciliary transition zone appears to function as a gate that controls ciliary membrane composition and separates the cytosol from the ciliary plasm. RBO_relaxed.owl GO:0036477 biolink:NamedThing somatodendritic compartment The region of a neuron that includes the cell body (cell soma) and dendrite(s), but excludes the axon. RBO_relaxed.owl GO:0042641 biolink:NamedThing actomyosin Any complex of actin, myosin, and accessory proteins. RBO_relaxed.owl GO:0042995 biolink:NamedThing cell projection A prolongation or process extending from a cell, e.g. a flagellum or axon. RBO_relaxed.owl GO:0043226 biolink:NamedThing organelle Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane. RBO_relaxed.owl GO:0044297 biolink:NamedThing cell body The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections. RBO_relaxed.owl GO:0071944 biolink:NamedThing cell periphery The broad region around and including the plasma membrane of a cell, encompassing the cell cortex (inside the cell), the plasma membrane, and any external encapsulating structures. RBO_relaxed.owl GO:0090734 biolink:NamedThing site of DNA damage A region of a chromosome at which DNA damage has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix. RBO_relaxed.owl GO:0097427 biolink:NamedThing microtubule bundle An arrangement of closely apposed microtubules running parallel to each other. RBO_relaxed.owl GO:0098793 biolink:NamedThing presynapse The part of a synapse that is part of the presynaptic cell. RBO_relaxed.owl GO:0098794 biolink:NamedThing postsynapse The part of a synapse that is part of the post-synaptic cell. RBO_relaxed.owl GO:0099080 biolink:NamedThing supramolecular complex A cellular component that consists of an indeterminate number of proteins or macromolecular complexes, organized into a regular, higher-order structure such as a polymer, sheet, network or a fiber. RBO_relaxed.owl GO:0005577 biolink:NamedThing fibrinogen complex A highly soluble, elongated protein complex found in blood plasma and involved in clot formation. It is converted into fibrin monomer by the action of thrombin. In the mouse, fibrinogen is a hexamer, 46 nm long and 9 nm maximal diameter, containing two sets of nonidentical chains (alpha, beta, and gamma) linked together by disulfide bonds. RBO_relaxed.owl GO:0005581 biolink:NamedThing collagen trimer A protein complex consisting of three collagen chains assembled into a left-handed triple helix. These trimers typically assemble into higher order structures. RBO_relaxed.owl GO:0030990 biolink:NamedThing intraciliary transport particle A nonmembrane-bound oligomeric protein complex that participates in bidirectional transport of molecules (cargo) along axonemal microtubules. RBO_relaxed.owl GO:0061695 biolink:NamedThing transferase complex, transferring phosphorus-containing groups A transferase complex capable of catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). RBO_relaxed.owl GO:0098796 biolink:NamedThing membrane protein complex Any protein complex that is part of a membrane. RBO_relaxed.owl GO:0098797 biolink:NamedThing plasma membrane protein complex Any protein complex that is part of the plasma membrane. RBO_relaxed.owl GO:0140513 biolink:NamedThing nuclear protein-containing complex A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus. RBO_relaxed.owl GO:1902494 biolink:NamedThing catalytic complex A protein complex which is capable of catalytic activity. RBO_relaxed.owl GO:1902495 biolink:NamedThing transmembrane transporter complex A transmembrane protein complex which enables the transfer of a substance from one side of a membrane to the other. RBO_relaxed.owl GO:1990351 biolink:NamedThing transporter complex A protein complex facilitating transport of molecules (proteins, small molecules, nucleic acids) into, out of or within a cell, or between cells. RBO_relaxed.owl GO:1990904 biolink:NamedThing ribonucleoprotein complex A macromolecular complex that contains both RNA and protein molecules. RBO_relaxed.owl GO:0005583 biolink:NamedThing fibrillar collagen trimer Any triple helical collagen trimer that forms fibrils. RBO_relaxed.owl GO:0030936 biolink:NamedThing transmembrane collagen trimer Any collagen trimer that passes through a lipid bilayer membrane. RBO_relaxed.owl GO:0098642 biolink:NamedThing network-forming collagen trimer A collagen trimer that forms networks. RBO_relaxed.owl GO:0098651 biolink:NamedThing basement membrane collagen trimer Any collagen timer that is part of a basement membrane. RBO_relaxed.owl GO:0005587 biolink:NamedThing collagen type IV trimer A collagen heterotrimer containing type IV alpha chains; [alpha1(IV)]2alpha2(IV) trimers are commonly observed, although more type IV alpha chains exist and may be present in type IV trimers; type IV collagen triple helices associate to form 3 dimensional nets within basement membranes. RBO_relaxed.owl GO:0005604 biolink:NamedThing basement membrane A collagen-containing extracellular matrix consisting of a thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. It consists of the basal lamina plus an associated layer of reticulin fibers. RBO_relaxed.owl GO:0062023 biolink:NamedThing collagen-containing extracellular matrix An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells. RBO_relaxed.owl GO:0043231 biolink:NamedThing intracellular membrane-bounded organelle Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. RBO_relaxed.owl GO:0005773 biolink:NamedThing vacuole A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol. RBO_relaxed.owl GO:0005794 biolink:NamedThing Golgi apparatus A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. RBO_relaxed.owl GO:0097708 biolink:NamedThing intracellular vesicle Any vesicle that is part of the intracellular region. RBO_relaxed.owl GO:0005635 biolink:NamedThing nuclear envelope The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space). RBO_relaxed.owl GO:0031967 biolink:NamedThing organelle envelope A double membrane structure enclosing an organelle, including two lipid bilayers and the region between them. In some cases, an organelle envelope may have more than two membranes. RBO_relaxed.owl GO:0043232 biolink:NamedThing intracellular non-membrane-bounded organelle Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes. RBO_relaxed.owl GO:0005730 biolink:NamedThing nucleolus A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. RBO_relaxed.owl GO:0005856 biolink:NamedThing cytoskeleton A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. RBO_relaxed.owl GO:0005775 biolink:NamedThing vacuolar lumen The volume enclosed within the vacuolar membrane. RBO_relaxed.owl GO:0043233 biolink:NamedThing organelle lumen The internal volume enclosed by the membranes of a particular organelle; includes the volume enclosed by a single organelle membrane, e.g. endoplasmic reticulum lumen, or the volume enclosed by the innermost of the two lipid bilayers of an organelle envelope, e.g. nuclear lumen. RBO_relaxed.owl GO:0070013 biolink:NamedThing intracellular organelle lumen An organelle lumen that is part of an intracellular organelle. RBO_relaxed.owl GO:0031981 biolink:NamedThing nuclear lumen The volume enclosed by the nuclear inner membrane. RBO_relaxed.owl GO:0005798 biolink:NamedThing Golgi-associated vesicle Any vesicle associated with the Golgi complex and involved in mediating transport within the Golgi or between the Golgi and other parts of the cell. RBO_relaxed.owl GO:0031410 biolink:NamedThing cytoplasmic vesicle A vesicle found in the cytoplasm of a cell. RBO_relaxed.owl GO:0030133 biolink:NamedThing transport vesicle Any of the vesicles of the constitutive secretory pathway, which carry cargo from the endoplasmic reticulum to the Golgi, between Golgi cisternae, from the Golgi to the ER (retrograde transport) or to destinations within or outside the cell. RBO_relaxed.owl GO:0048770 biolink:NamedThing pigment granule A small, subcellular membrane-bounded vesicle containing pigment and/or pigment precursor molecules. Pigment granule biogenesis is poorly understood, as pigment granules are derived from multiple sources including the endoplasmic reticulum, coated vesicles, lysosomes, and endosomes. RBO_relaxed.owl GO:0099503 biolink:NamedThing secretory vesicle A cytoplasmic, membrane bound vesicle that is capable of fusing to the plasma membrane to release its contents into the extracellular space. RBO_relaxed.owl GO:0005874 biolink:NamedThing microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. RBO_relaxed.owl GO:0099513 biolink:NamedThing polymeric cytoskeletal fiber A component of the cytoskeleton consisting of a homo or heteropolymeric fiber constructed from an indeterminate number of protein subunits. RBO_relaxed.owl GO:0005884 biolink:NamedThing actin filament A filamentous structure formed of a two-stranded helical polymer of the protein actin and associated proteins. Actin filaments are a major component of the contractile apparatus of skeletal muscle and the microfilaments of the cytoskeleton of eukaryotic cells. The filaments, comprising polymerized globular actin molecules, appear as flexible structures with a diameter of 5-9 nm. They are organized into a variety of linear bundles, two-dimensional networks, and three dimensional gels. In the cytoskeleton they are most highly concentrated in the cortex of the cell just beneath the plasma membrane. RBO_relaxed.owl GO:0005879 biolink:NamedThing axonemal microtubule A microtubule in the axoneme of a eukaryotic cilium or flagellum; an axoneme contains nine modified doublet microtubules, which may or may not surround a pair of single microtubules. RBO_relaxed.owl GO:0005880 biolink:NamedThing nuclear microtubule Any microtubule in the nucleus of a cell. RBO_relaxed.owl GO:0005881 biolink:NamedThing cytoplasmic microtubule Any microtubule in the cytoplasm of a cell. RBO_relaxed.owl GO:0005902 biolink:NamedThing microvillus Thin cylindrical membrane-covered projections on the surface of an animal cell containing a core bundle of actin filaments. Present in especially large numbers on the absorptive surface of intestinal cells. RBO_relaxed.owl GO:0098858 biolink:NamedThing actin-based cell projection A cell projection supported by an assembly of actin filaments, and which lacks microtubules. RBO_relaxed.owl GO:0005911 biolink:NamedThing cell-cell junction A cell junction that forms a connection between two or more cells of an organism; excludes direct cytoplasmic intercellular bridges, such as ring canals in insects. RBO_relaxed.owl GO:0070161 biolink:NamedThing anchoring junction A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix. RBO_relaxed.owl GO:0043227 biolink:NamedThing membrane-bounded organelle Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. RBO_relaxed.owl GO:0031982 biolink:NamedThing vesicle Any small, fluid-filled, spherical organelle enclosed by membrane. RBO_relaxed.owl GO:0065010 biolink:NamedThing extracellular membrane-bounded organelle Organized structure of distinctive morphology and function, bounded by a lipid bilayer membrane and occurring outside the cell. RBO_relaxed.owl GO:0120025 biolink:NamedThing plasma membrane bounded cell projection A prolongation or process extending from a cell and that is bounded by plasma membrane, e.g. a cilium, lamellipodium, or axon. RBO_relaxed.owl GO:0032059 biolink:NamedThing bleb A cell extension caused by localized decoupling of the cytoskeleton from the plasma membrane and characterized by rapid formation, rounded shape, and scarcity of organelles within the protrusion. Blebs are formed during apoptosis and other cellular processes, including cell locomotion, cell division, and as a result of physical or chemical stresses. RBO_relaxed.owl GO:0043005 biolink:NamedThing neuron projection A prolongation or process extending from a nerve cell, e.g. an axon or dendrite. RBO_relaxed.owl GO:0005975 biolink:NamedThing carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. RBO_relaxed.owl GO:0005977 biolink:NamedThing glycogen metabolic process The chemical reactions and pathways involving glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues in alpha-(1->4) glycosidic linkage, joined together by alpha-(1->6) glycosidic linkages. RBO_relaxed.owl GO:0005996 biolink:NamedThing monosaccharide metabolic process The chemical reactions and pathways involving monosaccharides, the simplest carbohydrates. They are polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides. RBO_relaxed.owl GO:0006006 biolink:NamedThing glucose metabolic process The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides. RBO_relaxed.owl GO:0006022 biolink:NamedThing aminoglycan metabolic process The chemical reactions and pathways involving aminoglycans, any polymer containing amino groups that consists of more than about 10 monosaccharide residues joined to each other by glycosidic linkages. RBO_relaxed.owl GO:0006082 biolink:NamedThing organic acid metabolic process The chemical reactions and pathways involving organic acids, any acidic compound containing carbon in covalent linkage. RBO_relaxed.owl GO:0006083 biolink:NamedThing acetate metabolic process The chemical reactions and pathways involving acetate, the anion of acetic acid. RBO_relaxed.owl GO:0006139 biolink:NamedThing nucleobase-containing compound metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. RBO_relaxed.owl GO:0006259 biolink:NamedThing DNA metabolic process Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. RBO_relaxed.owl GO:0006518 biolink:NamedThing peptide metabolic process The chemical reactions and pathways involving peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another. RBO_relaxed.owl GO:0006520 biolink:NamedThing amino acid metabolic process The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups. RBO_relaxed.owl GO:0006584 biolink:NamedThing catecholamine metabolic process The chemical reactions and pathways involving any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine. RBO_relaxed.owl GO:0006586 biolink:NamedThing indolalkylamine metabolic process The chemical reactions and pathways involving indolalkylamines, indole or indole derivatives containing a primary, secondary, or tertiary amine group. RBO_relaxed.owl GO:0006629 biolink:NamedThing lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. RBO_relaxed.owl GO:0006725 biolink:NamedThing cellular aromatic compound metabolic process The chemical reactions and pathways involving aromatic compounds, any organic compound characterized by one or more planar rings, each of which contains conjugated double bonds and delocalized pi electrons, as carried out by individual cells. RBO_relaxed.owl GO:0006790 biolink:NamedThing sulfur compound metabolic process The chemical reactions and pathways involving the nonmetallic element sulfur or compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione. RBO_relaxed.owl GO:0006793 biolink:NamedThing phosphorus metabolic process The chemical reactions and pathways involving the nonmetallic element phosphorus or compounds that contain phosphorus, usually in the form of a phosphate group (PO4). RBO_relaxed.owl GO:0006796 biolink:NamedThing phosphate-containing compound metabolic process The chemical reactions and pathways involving the phosphate group, the anion or salt of any phosphoric acid. RBO_relaxed.owl GO:0006807 biolink:NamedThing nitrogen compound metabolic process The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen. RBO_relaxed.owl GO:0008202 biolink:NamedThing steroid metabolic process The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus. RBO_relaxed.owl GO:0008206 biolink:NamedThing bile acid metabolic process The chemical reactions and pathways involving bile acids, a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine. RBO_relaxed.owl GO:0008291 biolink:NamedThing acetylcholine metabolic process The chemical reactions and pathways involving acetylcholine, the acetic acid ester of the organic base choline. Acetylcholine is a major neurotransmitter and neuromodulator both in the central and peripheral nervous systems. It also acts as a paracrine signal in various non-neural tissues. RBO_relaxed.owl GO:0009100 biolink:NamedThing glycoprotein metabolic process The chemical reactions and pathways involving glycoproteins, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide. RBO_relaxed.owl GO:0009112 biolink:NamedThing nucleobase metabolic process The chemical reactions and pathways involving a nucleobase, a nitrogenous base that is a constituent of a nucleic acid, e.g. the purines: adenine, guanine, hypoxanthine, xanthine and the pyrimidines: cytosine, uracil, thymine. RBO_relaxed.owl GO:0009308 biolink:NamedThing amine metabolic process The chemical reactions and pathways involving any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom. RBO_relaxed.owl GO:0009712 biolink:NamedThing catechol-containing compound metabolic process The chemical reactions and pathways involving a compound containing a pyrocatechol (1,2-benzenediol) nucleus or substituent. RBO_relaxed.owl GO:0009820 biolink:NamedThing alkaloid metabolic process The chemical reactions and pathways involving alkaloids, nitrogen containing natural products which are not otherwise classified as peptides, nonprotein amino acids, amines, cyanogenic glycosides, glucosinolates, cofactors, phytohormones or primary metabolites (such as purine or pyrimidine bases). RBO_relaxed.owl GO:0016070 biolink:NamedThing RNA metabolic process The cellular chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. RBO_relaxed.owl GO:0018958 biolink:NamedThing phenol-containing compound metabolic process The chemical reactions and pathways involving a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring. RBO_relaxed.owl GO:0019318 biolink:NamedThing hexose metabolic process The chemical reactions and pathways involving a hexose, any monosaccharide with a chain of six carbon atoms in the molecule. RBO_relaxed.owl GO:0019538 biolink:NamedThing protein metabolic process The chemical reactions and pathways involving a protein. Includes protein modification. RBO_relaxed.owl GO:0019748 biolink:NamedThing secondary metabolic process The chemical reactions and pathways resulting in many of the chemical changes of compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon. In multicellular organisms secondary metabolism is generally carried out in specific cell types, and may be useful for the organism as a whole. In unicellular organisms, secondary metabolism is often used for the production of antibiotics or for the utilization and acquisition of unusual nutrients. RBO_relaxed.owl GO:0019752 biolink:NamedThing carboxylic acid metabolic process The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-). RBO_relaxed.owl GO:0030203 biolink:NamedThing glycosaminoglycan metabolic process The chemical reactions and pathways involving glycosaminoglycans, any of a group of polysaccharides that contain amino sugars. RBO_relaxed.owl GO:0030212 biolink:NamedThing hyaluronan metabolic process The chemical reactions and pathways involving hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine. RBO_relaxed.owl GO:0032787 biolink:NamedThing monocarboxylic acid metabolic process The chemical reactions and pathways involving monocarboxylic acids, any organic acid containing one carboxyl (COOH) group or anion (COO-). RBO_relaxed.owl GO:0032963 biolink:NamedThing collagen metabolic process The chemical reactions and pathways involving collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%). RBO_relaxed.owl GO:0033013 biolink:NamedThing tetrapyrrole metabolic process The chemical reactions and pathways involving tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next. RBO_relaxed.owl GO:0035834 biolink:NamedThing indole alkaloid metabolic process The chemical reactions and pathways involving an indole alkaloid, an alkaloid containing an indole skeleton. RBO_relaxed.owl GO:0042180 biolink:NamedThing cellular ketone metabolic process The chemical reactions and pathways involving any of a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms, as carried out by individual cells. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups. RBO_relaxed.owl GO:0042415 biolink:NamedThing norepinephrine metabolic process The chemical reactions and pathways involving norepinephrine, a hormone secreted by the adrenal medulla, and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts in the central nervous system. It is also the demethylated biosynthetic precursor of epinephrine. RBO_relaxed.owl GO:0042428 biolink:NamedThing serotonin metabolic process The chemical reactions and pathways involving serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties. RBO_relaxed.owl GO:0042430 biolink:NamedThing indole-containing compound metabolic process The chemical reactions and pathways involving compounds that contain an indole (2,3-benzopyrrole) skeleton. RBO_relaxed.owl GO:0043170 biolink:NamedThing macromolecule metabolic process The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. RBO_relaxed.owl GO:0043436 biolink:NamedThing oxoacid metabolic process The chemical reactions and pathways involving any oxoacid; an oxoacid is a compound which contains oxygen, at least one other element, and at least one hydrogen bound to oxygen, and which produces a conjugate base by loss of positive hydrogen ion(s) (hydrons). RBO_relaxed.owl GO:0043603 biolink:NamedThing amide metabolic process The chemical reactions and pathways involving an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group, as carried out by individual cells. RBO_relaxed.owl GO:0043648 biolink:NamedThing dicarboxylic acid metabolic process The chemical reactions and pathways involving dicarboxylic acids, any organic acid containing two carboxyl (COOH) groups or anions (COO-). RBO_relaxed.owl GO:0044237 biolink:NamedThing cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. RBO_relaxed.owl GO:0044238 biolink:NamedThing primary metabolic process The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism. RBO_relaxed.owl GO:0044281 biolink:NamedThing small molecule metabolic process The chemical reactions and pathways involving small molecules, any low molecular weight, monomeric, non-encoded molecule. RBO_relaxed.owl GO:0046483 biolink:NamedThing heterocycle metabolic process The chemical reactions and pathways involving heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings). RBO_relaxed.owl GO:0071704 biolink:NamedThing organic substance metabolic process The chemical reactions and pathways involving an organic substance, any molecular entity containing carbon. RBO_relaxed.owl GO:0072592 biolink:NamedThing oxygen metabolic process The chemical reactions and pathways involving diatomic oxygen (O2). RBO_relaxed.owl GO:0090304 biolink:NamedThing nucleic acid metabolic process Any cellular metabolic process involving nucleic acids. RBO_relaxed.owl GO:0097164 biolink:NamedThing ammonium ion metabolic process The chemical reactions and pathways involving the ammonium ion. RBO_relaxed.owl GO:1900619 biolink:NamedThing acetate ester metabolic process The chemical reactions and pathways involving an acetate ester, any carboxylic ester where the carboxylic acid component is acetic acid. RBO_relaxed.owl GO:1901135 biolink:NamedThing carbohydrate derivative metabolic process The chemical reactions and pathways involving carbohydrate derivative. RBO_relaxed.owl GO:1901142 biolink:NamedThing insulin metabolic process The chemical reactions and pathways involving insulin. RBO_relaxed.owl GO:1901160 biolink:NamedThing primary amino compound metabolic process The chemical reactions and pathways involving primary amino compound. RBO_relaxed.owl GO:1901360 biolink:NamedThing organic cyclic compound metabolic process The chemical reactions and pathways involving organic cyclic compound. RBO_relaxed.owl GO:1901564 biolink:NamedThing organonitrogen compound metabolic process The chemical reactions and pathways involving organonitrogen compound. RBO_relaxed.owl GO:1901605 biolink:NamedThing alpha-amino acid metabolic process The chemical reactions and pathways involving an alpha-amino acid. RBO_relaxed.owl GO:1901615 biolink:NamedThing organic hydroxy compound metabolic process The chemical reactions and pathways involving organic hydroxy compound. RBO_relaxed.owl GO:1903510 biolink:NamedThing mucopolysaccharide metabolic process The chemical reactions and pathways involving mucopolysaccharide. RBO_relaxed.owl GO:0006112 biolink:NamedThing energy reserve metabolic process The chemical reactions and pathways by which a cell derives energy from stored compounds such as fats or glycogen. RBO_relaxed.owl GO:0055086 biolink:NamedThing nucleobase-containing small molecule metabolic process The cellular chemical reactions and pathways involving a nucleobase-containing small molecule: a nucleobase, a nucleoside, or a nucleotide. RBO_relaxed.owl GO:0006091 biolink:NamedThing generation of precursor metabolites and energy The chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and any process involved in the liberation of energy from these substances. RBO_relaxed.owl GO:0006413 biolink:NamedThing translational initiation The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA. RBO_relaxed.owl GO:0034641 biolink:NamedThing cellular nitrogen compound metabolic process The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds, as carried out by individual cells. RBO_relaxed.owl GO:0015980 biolink:NamedThing energy derivation by oxidation of organic compounds The chemical reactions and pathways by which a cell derives energy from organic compounds; results in the oxidation of the compounds from which energy is released. RBO_relaxed.owl GO:0044270 biolink:NamedThing cellular nitrogen compound catabolic process The chemical reactions and pathways resulting in the breakdown of organic and inorganic nitrogenous compounds. RBO_relaxed.owl GO:0044271 biolink:NamedThing cellular nitrogen compound biosynthetic process The chemical reactions and pathways resulting in the formation of organic and inorganic nitrogenous compounds. RBO_relaxed.owl GO:0006281 biolink:NamedThing DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. RBO_relaxed.owl GO:0006974 biolink:NamedThing DNA damage response Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism. RBO_relaxed.owl GO:0006309 biolink:NamedThing apoptotic DNA fragmentation The cleavage of DNA during apoptosis, which usually occurs in two stages: cleavage into fragments of about 50 kbp followed by cleavage between nucleosomes to yield 200 bp fragments. RBO_relaxed.owl GO:0032986 biolink:NamedThing protein-DNA complex disassembly The disaggregation of a protein-DNA complex into its constituent components. RBO_relaxed.owl GO:0006403 biolink:NamedThing RNA localization A process in which RNA is transported to, or maintained in, a specific location. RBO_relaxed.owl GO:0033036 biolink:NamedThing macromolecule localization Any process in which a macromolecule is transported to, or maintained in, a specific location. RBO_relaxed.owl GO:0010876 biolink:NamedThing lipid localization Any process in which a lipid is transported to, or maintained in, a specific location. RBO_relaxed.owl GO:0033037 biolink:NamedThing polysaccharide localization Any process in which a polysaccharide is transported to, or maintained in, a specific location. RBO_relaxed.owl GO:0070727 biolink:NamedThing cellular macromolecule localization Any process in which a macromolecule is transported to, and/or maintained in, a specific location at the level of a cell. Localization at the cellular level encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell. RBO_relaxed.owl GO:0006415 biolink:NamedThing translational termination The process resulting in the release of a polypeptide chain from the ribosome, usually in response to a termination codon (UAA, UAG, or UGA in the universal genetic code). RBO_relaxed.owl GO:0032984 biolink:NamedThing protein-containing complex disassembly The disaggregation of a protein-containing macromolecular complex into its constituent components. RBO_relaxed.owl GO:0032988 biolink:NamedThing protein-RNA complex disassembly The disaggregation of a protein-RNA complex into its constituent components. RBO_relaxed.owl GO:0051261 biolink:NamedThing protein depolymerization The process in which protein polymers, compounds composed of a large number of component monomers, are broken down. Depolymerization occurs by the successive removal of monomers from an existing poly- or oligomeric protein. RBO_relaxed.owl GO:0010608 biolink:NamedThing post-transcriptional regulation of gene expression Any process that modulates the frequency, rate or extent of gene expression after the production of an RNA transcript. RBO_relaxed.owl GO:0043143 biolink:NamedThing regulation of translation by machinery localization Any process in which proteins and protein complexes involved in translation are transported to, or maintained in, a specific location. RBO_relaxed.owl GO:0007039 biolink:NamedThing protein catabolic process in the vacuole The chemical reactions and pathways resulting in the breakdown of a protein in the vacuole, usually by the action of vacuolar proteases. RBO_relaxed.owl GO:0006576 biolink:NamedThing biogenic amine metabolic process The chemical reactions and pathways occurring at the level of individual cells involving any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters. RBO_relaxed.owl GO:0042401 biolink:NamedThing biogenic amine biosynthetic process The chemical reactions and pathways occurring at the level of individual cells resulting in the formation of any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters. RBO_relaxed.owl GO:0120178 biolink:NamedThing steroid hormone biosynthetic process The chemical reactions and pathways resulting in the formation of any steroid hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone. RBO_relaxed.owl GO:0044258 biolink:NamedThing intestinal lipid catabolic process The chemical reactions and pathways resulting in the breakdown into fatty acids and monoglycerides of lipids in the small intestine. Lipids are broken down by lipases released by the pancreas. RBO_relaxed.owl GO:0051234 biolink:NamedThing establishment of localization Any process that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation. RBO_relaxed.owl GO:0045184 biolink:NamedThing establishment of protein localization The directed movement of a protein to a specific location. RBO_relaxed.owl GO:0051236 biolink:NamedThing establishment of RNA localization The directed movement of RNA to a specific location. RBO_relaxed.owl GO:0051303 biolink:NamedThing establishment of chromosome localization The directed movement of a chromosome to a specific location. RBO_relaxed.owl GO:0051649 biolink:NamedThing establishment of localization in cell Any process, occuring in a cell, that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation. RBO_relaxed.owl GO:0051650 biolink:NamedThing establishment of vesicle localization The directed movement of a vesicle to a specific location. RBO_relaxed.owl GO:0051656 biolink:NamedThing establishment of organelle localization The directed movement of an organelle to a specific location. RBO_relaxed.owl GO:0051683 biolink:NamedThing establishment of Golgi localization The directed movement of the Golgi to a specific location. RBO_relaxed.owl GO:0070634 biolink:NamedThing transepithelial ammonium transport The directed movement of ammonium ions from one side of an epithelium to the other. RBO_relaxed.owl GO:0032594 biolink:NamedThing protein transport within lipid bilayer The directed movement of a protein from one location to another within a lipid bilayer. RBO_relaxed.owl GO:0043001 biolink:NamedThing Golgi to plasma membrane protein transport The directed movement of proteins from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane. RBO_relaxed.owl GO:0007034 biolink:NamedThing vacuolar transport The directed movement of substances into, out of or within a vacuole. RBO_relaxed.owl GO:0007097 biolink:NamedThing nuclear migration The directed movement of the nucleus to a specific location within a cell. RBO_relaxed.owl GO:0008088 biolink:NamedThing axo-dendritic transport The directed movement of organelles or molecules along microtubules in neuron projections. RBO_relaxed.owl GO:0030050 biolink:NamedThing vesicle transport along actin filament Movement of a vesicle along an actin filament, mediated by motor proteins. RBO_relaxed.owl GO:0030705 biolink:NamedThing cytoskeleton-dependent intracellular transport The directed movement of substances along cytoskeletal fibers such as microfilaments or microtubules within a cell. RBO_relaxed.owl GO:0072384 biolink:NamedThing organelle transport along microtubule The directed movement of an organelle along a microtubule, mediated by motor proteins. This process begins with the attachment of an organelle to a microtubule, and ends when the organelle reaches its final destination. RBO_relaxed.owl GO:0098840 biolink:NamedThing protein transport along microtubule The directed movement of a protein along a microtubule, mediated by motor proteins. RBO_relaxed.owl GO:0099112 biolink:NamedThing microtubule polymerization based protein transport The transport of a protein driven by polymerization of a microtubule to which it is attached. RBO_relaxed.owl GO:0099515 biolink:NamedThing actin filament-based transport The transport of organelles or other particles from one location in the cell to another along actin filaments. RBO_relaxed.owl GO:0099518 biolink:NamedThing vesicle cytoskeletal trafficking The directed movement of a vesicle along a cytoskeletal fiber such as a microtubule or and actin filament, mediated by motor proteins. RBO_relaxed.owl GO:0099640 biolink:NamedThing axo-dendritic protein transport The directed movement of proteins along microtubules in neuron projections. RBO_relaxed.owl GO:0006893 biolink:NamedThing Golgi to plasma membrane transport The directed movement of substances from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane, where they fuse and release their contents by exocytosis. RBO_relaxed.owl GO:0006896 biolink:NamedThing Golgi to vacuole transport The directed movement of substances from the Golgi to the vacuole. RBO_relaxed.owl GO:0099003 biolink:NamedThing vesicle-mediated transport in synapse Any vesicle-mediated transport that occurs in a synapse. RBO_relaxed.owl GO:0110077 biolink:NamedThing vesicle-mediated intercellular transport A cellular transport process in which transported substances are moved in extracellular vesicles between cells; transported substances are enclosed in the vesicle lumen or located in the extracellular vesicle membrane. RBO_relaxed.owl GO:0006892 biolink:NamedThing post-Golgi vesicle-mediated transport The directed movement of substances from the Golgi to other parts of the cell, including organelles and the plasma membrane, mediated by small transport vesicles. RBO_relaxed.owl GO:0006903 biolink:NamedThing vesicle targeting The process in which vesicles are directed to specific destination membranes. Targeting involves coordinated interactions among cytoskeletal elements (microtubules or actin filaments), motor proteins, molecules at the vesicle membrane and target membrane surfaces, and vesicle cargo. RBO_relaxed.owl GO:0007154 biolink:NamedThing cell communication Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. RBO_relaxed.owl GO:0007163 biolink:NamedThing establishment or maintenance of cell polarity Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns. RBO_relaxed.owl GO:0007165 biolink:NamedThing signal transduction The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. RBO_relaxed.owl GO:0007416 biolink:NamedThing synapse assembly The aggregation, arrangement and bonding together of a set of components to form a synapse. This process ends when the synapse is mature (functional). RBO_relaxed.owl GO:0008219 biolink:NamedThing cell death Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as apoptotic bodies). The cell corpse (or its fragments) may be engulfed by an adjacent cell in vivo, but engulfment of whole cells should not be considered a strict criteria to define cell death as, under some circumstances, live engulfed cells can be released from phagosomes (see PMID:18045538). RBO_relaxed.owl GO:0022402 biolink:NamedThing cell cycle process The cellular process that ensures successive accurate and complete genome replication and chromosome segregation. RBO_relaxed.owl GO:0022406 biolink:NamedThing membrane docking The initial attachment of a membrane or protein to a target membrane. Docking requires only that the proteins come close enough to interact and adhere. RBO_relaxed.owl GO:0030029 biolink:NamedThing actin filament-based process Any cellular process that depends upon or alters the actin cytoskeleton, that part of the cytoskeleton comprising actin filaments and their associated proteins. RBO_relaxed.owl GO:0033059 biolink:NamedThing cellular pigmentation The deposition or aggregation of coloring matter in a cell. RBO_relaxed.owl GO:0048280 biolink:NamedThing vesicle fusion with Golgi apparatus The joining of the lipid bilayer membrane around a vesicle to the lipid bilayer membrane around the Golgi. RBO_relaxed.owl GO:0050808 biolink:NamedThing synapse organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell). RBO_relaxed.owl GO:0051301 biolink:NamedThing cell division The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. RBO_relaxed.owl GO:0051469 biolink:NamedThing vesicle fusion with vacuole The joining of the lipid bilayer membrane around a vesicle with the lipid bilayer membrane around the vacuole. RBO_relaxed.owl GO:0051641 biolink:NamedThing cellular localization A cellular localization process whereby a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within a cell including the localization of substances or cellular entities to the cell membrane. RBO_relaxed.owl GO:0051674 biolink:NamedThing localization of cell Any process in which a cell is transported to, and/or maintained in, a specific location. RBO_relaxed.owl GO:0071840 biolink:NamedThing cellular component organization or biogenesis A process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a cellular component. RBO_relaxed.owl GO:0097194 biolink:NamedThing execution phase of apoptosis A stage of the apoptotic process that starts with the controlled breakdown of the cell through the action of effector caspases or other effector molecules (e.g. cathepsins, calpains etc.). Key steps of the execution phase are rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died. RBO_relaxed.owl GO:0140029 biolink:NamedThing exocytic process The cellular processes that contribute to exocytosis. RBO_relaxed.owl GO:1990748 biolink:NamedThing cellular detoxification Any process carried out at the cellular level that reduces or removes the toxicity of a toxic substance. These may include transport of the toxic substance away from sensitive areas and to compartments or complexes whose purpose is sequestration of the toxic substance. RBO_relaxed.owl GO:0012501 biolink:NamedThing programmed cell death A process which begins when a cell receives an internal or external signal and activates a series of biochemical events (signaling pathway). The process ends with the death of the cell. RBO_relaxed.owl GO:0010623 biolink:NamedThing programmed cell death involved in cell development The activation of endogenous cellular processes that result in the death of a cell as part of its development. RBO_relaxed.owl GO:0006921 biolink:NamedThing cellular component disassembly involved in execution phase of apoptosis The breakdown of structures such as organelles, proteins, or other macromolecular structures during apoptosis. RBO_relaxed.owl GO:0007019 biolink:NamedThing microtubule depolymerization The removal of tubulin heterodimers from one or both ends of a microtubule. RBO_relaxed.owl GO:0022617 biolink:NamedThing extracellular matrix disassembly A process that results in the breakdown of the extracellular matrix. RBO_relaxed.owl GO:0030397 biolink:NamedThing membrane disassembly The controlled breakdown of any cell membrane in the context of a normal process such as autophagy. RBO_relaxed.owl GO:0032790 biolink:NamedThing ribosome disassembly The disaggregation of a ribosome into its constituent components; includes the dissociation of ribosomal subunits. RBO_relaxed.owl GO:0034769 biolink:NamedThing basement membrane disassembly The controlled breakdown of the basement membrane in the context of a normal process such as imaginal disc eversion. RBO_relaxed.owl GO:0061523 biolink:NamedThing cilium disassembly A cellular process that results in the breakdown of a cilium. RBO_relaxed.owl GO:0090166 biolink:NamedThing Golgi disassembly A cellular process that results in the breakdown of a Golgi apparatus that contributes to Golgi inheritance. RBO_relaxed.owl GO:0098883 biolink:NamedThing synapse pruning A cellular process that results in the controlled breakdown of synapse. After it starts the process is continuous until the synapse has disappeared. RBO_relaxed.owl GO:0150146 biolink:NamedThing cell junction disassembly The disaggregation of a cell junction into its constituent components. RBO_relaxed.owl GO:0150147 biolink:NamedThing cell-cell junction disassembly The disaggregation of a cell-cell junction into its constituent components. RBO_relaxed.owl GO:1903008 biolink:NamedThing organelle disassembly The disaggregation of an organelle into its constituent components. RBO_relaxed.owl GO:0007043 biolink:NamedThing cell-cell junction assembly The aggregation, arrangement and bonding together of a set of components to form a junction between cells. RBO_relaxed.owl GO:0045216 biolink:NamedThing cell-cell junction organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cell-cell junction. A cell-cell junction is a specialized region of connection between two cells. RBO_relaxed.owl GO:0007059 biolink:NamedThing chromosome segregation The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles. RBO_relaxed.owl GO:0010032 biolink:NamedThing meiotic chromosome condensation Compaction of chromatin structure prior to meiosis in eukaryotic cells. RBO_relaxed.owl GO:0030263 biolink:NamedThing apoptotic chromosome condensation The compaction of chromatin during apoptosis. RBO_relaxed.owl GO:0051078 biolink:NamedThing meiotic nuclear membrane disassembly The cell cycle process in which the controlled breakdown of the nuclear membranes during meiotic cell division occurs. RBO_relaxed.owl GO:0051647 biolink:NamedThing nucleus localization Any process in which the nucleus is transported to, and/or maintained in, a specific location within the cell. RBO_relaxed.owl GO:0007113 biolink:NamedThing endomitotic cell cycle A mitotic cell cycle in which chromosomes are replicated and sister chromatids separate, but spindle formation, nuclear membrane breakdown and nuclear division do not occur, resulting in an increased number of chromosomes in the cell. RBO_relaxed.owl GO:0140013 biolink:NamedThing meiotic nuclear division One of the two nuclear divisions that occur as part of the meiotic cell cycle. RBO_relaxed.owl GO:0086065 biolink:NamedThing cell communication involved in cardiac conduction Any process that mediates interactions between a cell and its surroundings that contributes to the process of cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. RBO_relaxed.owl GO:0007268 biolink:NamedThing chemical synaptic transmission The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse. RBO_relaxed.owl GO:0098916 biolink:NamedThing anterograde trans-synaptic signaling Cell-cell signaling from pre to post-synapse, across the synaptic cleft. RBO_relaxed.owl GO:0007269 biolink:NamedThing neurotransmitter secretion The regulated release of neurotransmitter from the presynapse into the synaptic cleft via calcium-regulated exocytosis during synaptic transmission. RBO_relaxed.owl GO:0007271 biolink:NamedThing synaptic transmission, cholinergic The vesicular release of acetylcholine from a presynapse, across a chemical synapse, the subsequent activation of dopamine receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse. RBO_relaxed.owl GO:0007276 biolink:NamedThing gamete generation The generation and maintenance of gametes in a multicellular organism. A gamete is a haploid reproductive cell. RBO_relaxed.owl GO:0007292 biolink:NamedThing female gamete generation Generation of the female gamete; specialised haploid cells produced by meiosis and along with a male gamete takes part in sexual reproduction. RBO_relaxed.owl GO:0008544 biolink:NamedThing epidermis development The process whose specific outcome is the progression of the epidermis over time, from its formation to the mature structure. The epidermis is the outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species. RBO_relaxed.owl GO:0048534 biolink:NamedThing hematopoietic or lymphoid organ development The process whose specific outcome is the progression of any organ involved in hematopoiesis (also known as hemopoiesis) or lymphoid cell activation over time, from its formation to the mature structure. Such development includes differentiation of resident cell types (stromal cells) and of migratory cell types dependent on the unique microenvironment afforded by the organ for their proper differentiation. RBO_relaxed.owl GO:0048806 biolink:NamedThing genitalia development The process whose specific outcome is the progression of the genitalia over time, from its formation to the mature structure. RBO_relaxed.owl GO:0060348 biolink:NamedThing bone development The process whose specific outcome is the progression of bone over time, from its formation to the mature structure. Bone is the hard skeletal connective tissue consisting of both mineral and cellular components. RBO_relaxed.owl GO:0007601 biolink:NamedThing visual perception The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image. RBO_relaxed.owl GO:0050953 biolink:NamedThing sensory perception of light stimulus The series of events required for an organism to receive a sensory light stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. RBO_relaxed.owl GO:0007605 biolink:NamedThing sensory perception of sound The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound. RBO_relaxed.owl GO:0050954 biolink:NamedThing sensory perception of mechanical stimulus The series of events required for an organism to receive a sensory mechanical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. RBO_relaxed.owl GO:0050975 biolink:NamedThing sensory perception of touch The series of events required for an organism to receive a touch stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. The perception of touch in animals is mediated by mechanoreceptors in the skin and mucous membranes and is the sense by which contact with objects gives evidence as to certain of their qualities. Different types of touch can be perceived (for example, light, coarse, pressure and tickling) and the stimulus may be external or internal (e.g. the feeling of a full stomach). RBO_relaxed.owl GO:0007606 biolink:NamedThing sensory perception of chemical stimulus The series of events required for an organism to receive a sensory chemical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. RBO_relaxed.owl GO:0019233 biolink:NamedThing sensory perception of pain The series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal. Pain is medically defined as the physical sensation of discomfort or distress caused by injury or illness, so can hence be described as a harmful stimulus which signals current (or impending) tissue damage. Pain may come from extremes of temperature, mechanical damage, electricity or from noxious chemical substances. This is a neurological process. RBO_relaxed.owl GO:0050952 biolink:NamedThing sensory perception of electrical stimulus The series of events required for an organism to receive a sensory electrical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. RBO_relaxed.owl GO:0007626 biolink:NamedThing locomotory behavior The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions. RBO_relaxed.owl NBO:0000313 biolink:NamedThing behavior process "The action, reaction, or performance of an organism in response to external or internal stimuli." [GO:GO\:0007610] RBO_relaxed.owl GO:0008104 biolink:NamedThing protein localization Any process in which a protein is transported to, or maintained in, a specific location. RBO_relaxed.owl GO:0031503 biolink:NamedThing protein-containing complex localization A localization process that acts on a protein complex; the complex is transported to, or maintained in, a specific location. RBO_relaxed.owl GO:0032252 biolink:NamedThing secretory granule localization Any process in which a secretory granule is transported to, and/or maintained in, a specific location within the cell. RBO_relaxed.owl GO:0032253 biolink:NamedThing dense core granule localization Any process in which a dense core granule is transported to, and/or maintained in, a specific location within the cell. RBO_relaxed.owl GO:0033750 biolink:NamedThing ribosome localization A process in which a ribosome is transported to, and/or maintained in, a specific location. RBO_relaxed.owl GO:0050000 biolink:NamedThing chromosome localization Any process in which a chromosome is transported to, or maintained in, a specific location. RBO_relaxed.owl GO:0051640 biolink:NamedThing organelle localization Any process in which an organelle is transported to, and/or maintained in, a specific location. RBO_relaxed.owl GO:0051645 biolink:NamedThing Golgi localization Any process in which the Golgi is transported to, and/or maintained in, a specific location within the cell. RBO_relaxed.owl GO:0051648 biolink:NamedThing vesicle localization Any process in which a vesicle or vesicles are transported to, and/or maintained in, a specific location. RBO_relaxed.owl GO:0051668 biolink:NamedThing localization within membrane Any process in which a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within a membrane. RBO_relaxed.owl GO:0051875 biolink:NamedThing pigment granule localization Any process in which a pigment granule is transported to, and/or maintained in, a specific location within the cell. RBO_relaxed.owl GO:1990849 biolink:NamedThing vacuolar localization Any process in which the vacuole is transported to, and/or maintained in, a specific location within the cell. RBO_relaxed.owl GO:0022853 biolink:NamedThing active monoatomic ion transmembrane transporter activity Enables the transfer of an ion from one side of a membrane to the other up the solute's concentration gradient. This is carried out by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction. RBO_relaxed.owl GO:0008356 biolink:NamedThing asymmetric cell division The asymmetric division of cells to produce two daughter cells with different developmental potentials. It is of fundamental significance for the generation of cell diversity. RBO_relaxed.owl GO:0010481 biolink:NamedThing epidermal cell division Any process resulting in the physical partitioning and separation of an epidermal cell, any of the cells making up the epidermis, into daughter cells. RBO_relaxed.owl GO:0014872 biolink:NamedThing myoblast division The process resulting in the physical partitioning and separation of a myoblast into daughter cells. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. RBO_relaxed.owl GO:0017145 biolink:NamedThing stem cell division The self-renewing division of a stem cell. A stem cell is an undifferentiated cell, in the embryo or adult, that can undergo unlimited division and give rise to one or several different cell types. RBO_relaxed.owl GO:0040016 biolink:NamedThing embryonic cleavage The first few specialized divisions of an activated animal egg. RBO_relaxed.owl GO:0048103 biolink:NamedThing somatic stem cell division The self-renewing division of a somatic stem cell, a stem cell that can give rise to cell types of the body other than those of the germ-line. RBO_relaxed.owl GO:0055057 biolink:NamedThing neuroblast division The process resulting in the physical partitioning and separation of a neuroblast into daughter cells. A neuroblast is any cell that will divide and give rise to a neuron. RBO_relaxed.owl GO:0035592 biolink:NamedThing establishment of protein localization to extracellular region The directed movement of a protein to a specific location within the extracellular region. RBO_relaxed.owl GO:0009314 biolink:NamedThing response to radiation Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electromagnetic radiation stimulus. Electromagnetic radiation is a propagating wave in space with electric and magnetic components. These components oscillate at right angles to each other and to the direction of propagation. RBO_relaxed.owl GO:0009582 biolink:NamedThing detection of abiotic stimulus The series of events in which an (non-living) abiotic stimulus is received by a cell and converted into a molecular signal. RBO_relaxed.owl GO:0051602 biolink:NamedThing response to electrical stimulus Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electrical stimulus. RBO_relaxed.owl GO:0071214 biolink:NamedThing cellular response to abiotic stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abiotic (non-living) stimulus. RBO_relaxed.owl GO:0010212 biolink:NamedThing response to ionizing radiation Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ionizing radiation stimulus. Ionizing radiation is radiation with sufficient energy to remove electrons from atoms and may arise from spontaneous decay of unstable isotopes, resulting in alpha and beta particles and gamma rays. Ionizing radiation also includes X-rays. RBO_relaxed.owl GO:0071478 biolink:NamedThing cellular response to radiation Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electromagnetic radiation stimulus. Electromagnetic radiation is a propagating wave in space with electric and magnetic components. These components oscillate at right angles to each other and to the direction of propagation. RBO_relaxed.owl GO:0009581 biolink:NamedThing detection of external stimulus The series of events in which an external stimulus is received by a cell and converted into a molecular signal. RBO_relaxed.owl GO:0043207 biolink:NamedThing response to external biotic stimulus Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external biotic stimulus, an external stimulus caused by, or produced by living things. RBO_relaxed.owl GO:0050906 biolink:NamedThing detection of stimulus involved in sensory perception The series of events involved in sensory perception in which a sensory stimulus is received and converted into a molecular signal. RBO_relaxed.owl GO:0062149 biolink:NamedThing detection of stimulus involved in sensory perception of pain The series of events involved in the perception of pain in which a stimulus is received and converted into a molecular signal. RBO_relaxed.owl GO:0009583 biolink:NamedThing detection of light stimulus The series of events in which a light stimulus (in the form of photons) is received and converted into a molecular signal. RBO_relaxed.owl GO:0050981 biolink:NamedThing detection of electrical stimulus The series of events by which an electrical stimulus is received and converted into a molecular signal. RBO_relaxed.owl GO:0009584 biolink:NamedThing detection of visible light The series of events in which a visible light stimulus is received by a cell and converted into a molecular signal. A visible light stimulus is electromagnetic radiation that can be perceived visually by an organism; for organisms lacking a visual system, this can be defined as light with a wavelength within the range 380 to 780 nm. RBO_relaxed.owl GO:0050908 biolink:NamedThing detection of light stimulus involved in visual perception The series of events involved in visual perception in which a light stimulus is received and converted into a molecular signal. RBO_relaxed.owl GO:0050962 biolink:NamedThing detection of light stimulus involved in sensory perception The series of events in which a light stimulus is received by a cell and converted into a molecular signal as part of the sensory perception of light. RBO_relaxed.owl GO:0009725 biolink:NamedThing response to hormone Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus. RBO_relaxed.owl GO:0010160 biolink:NamedThing formation of animal organ boundary The regionalization process that specifies animal organ primordium boundaries resulting in a restriction of organogenesis to a limited spatial domain and keeping the organ separate from surrounding tissues. RBO_relaxed.owl GO:0021532 biolink:NamedThing neural tube patterning The regionalization process that regulates the coordinated growth that establishes the non-random spatial arrangement of the neural tube. RBO_relaxed.owl GO:0060897 biolink:NamedThing neural plate regionalization The pattern specification process that results in the subdivision of an axis or axes of the neural plate in space to define an area or volume in which specific patterns of cell differentiation will take place or in which cells interpret a specific environment. RBO_relaxed.owl GO:1900115 biolink:NamedThing extracellular regulation of signal transduction Any regulation of signal transduction that takes place in the extracellular region. RBO_relaxed.owl GO:0010070 biolink:NamedThing zygote asymmetric cell division The division of the zygote into two daughter cells that will adopt developmentally distinct potentials. RBO_relaxed.owl GO:0048132 biolink:NamedThing female germ-line stem cell asymmetric division The self-renewing division of a germline stem cell in the female gonad, to produce a daughter stem cell and a daughter germ cell, which will divide to form the female gametes. RBO_relaxed.owl GO:0055059 biolink:NamedThing asymmetric neuroblast division The process resulting in the physical partitioning and separation of a neuroblast into two daughter cells with different developmental potentials. RBO_relaxed.owl GO:0098722 biolink:NamedThing asymmetric stem cell division Division of a stem cell during which it retains its identity and buds off a daughter cell with a new identity. RBO_relaxed.owl GO:0098728 biolink:NamedThing germline stem cell asymmetric division The self-renewing division of a germline stem cell, to produce a daughter stem cell and a daughter germ cell which will divide to form one or more gametes. RBO_relaxed.owl GO:0010165 biolink:NamedThing response to X-ray Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of X-ray radiation. An X-ray is a form of electromagnetic radiation with a wavelength in the range of 10 nanometers to 100 picometers (corresponding to frequencies in the range 30 PHz to 3 EHz). RBO_relaxed.owl GO:0010332 biolink:NamedThing response to gamma radiation Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gamma radiation stimulus. Gamma radiation is a form of electromagnetic radiation (EMR) or light emission of a specific frequency produced from sub-atomic particle interaction, such as electron-positron annihilation and radioactive decay. Gamma rays are generally characterized as EMR having the highest frequency and energy, and also the shortest wavelength, within the electromagnetic radiation spectrum. RBO_relaxed.owl GO:0071479 biolink:NamedThing cellular response to ionizing radiation Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ionizing radiation stimulus. Ionizing radiation is radiation with sufficient energy to remove electrons from atoms and may arise from spontaneous decay of unstable isotopes, resulting in alpha and beta particles and gamma rays. Ionizing radiation also includes X-rays. RBO_relaxed.owl GO:0040034 biolink:NamedThing regulation of development, heterochronic Any process that modulates the consistent predetermined time point at which an integrated living unit or organism progresses from an initial condition to a later condition and the rate at which this time point is reached. RBO_relaxed.owl GO:0045165 biolink:NamedThing cell fate commitment The cellular developmental process by which a cell establishes the intrinsic character of a cell or tissue region irreversibly committing it to a particular fate. RBO_relaxed.owl GO:0010938 biolink:NamedThing cytoplasmic microtubule depolymerization The removal of tubulin heterodimers from one or both ends of a cytoplasmic microtubule. RBO_relaxed.owl GO:0060404 biolink:NamedThing axonemal microtubule depolymerization The removal of tubulin heterodimers from one or both ends of an axonemal microtubule. An axonemal microtubule is a microtubule in the axoneme of a cilium or flagellum; an axoneme contains nine modified doublet microtubules surrounding a pair of single microtubules. RBO_relaxed.owl GO:0099098 biolink:NamedThing microtubule polymerization based movement The movement of a cellular component as a result of microtubule polymerization. RBO_relaxed.owl GO:0014055 biolink:NamedThing acetylcholine secretion, neurotransmission The regulated release of acetylcholine by a cell. The acetylcholine acts as a neurotransmitter that acts in both the peripheral nervous system (PNS) and central nervous system (CNS). RBO_relaxed.owl GO:0014860 biolink:NamedThing neurotransmitter secretion involved in regulation of skeletal muscle contraction The regulated release of neurotransmitter into the synaptic cleft involved in skeletal muscle contraction. A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, gamma aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin. RBO_relaxed.owl GO:0060096 biolink:NamedThing serotonin secretion, neurotransmission The regulated release of serotonin by a cell, in which released serotonin acts as a neurotransmitter. RBO_relaxed.owl GO:0061533 biolink:NamedThing norepinephrine secretion, neurotransmission The regulated release of norepinephrine by a cell, in which the norepinephrine acts as a neurotransmitter. RBO_relaxed.owl GO:0160043 biolink:NamedThing catecholamine secretion, neurotransmission The regulated release of catecholamine by a cell in which the catecholamine acts as a neurotransmitter. RBO_relaxed.owl GO:0043501 biolink:NamedThing skeletal muscle adaptation Any process in which skeletal muscles change their phenotypic profiles in response to altered functional demands and a variety of signals. RBO_relaxed.owl GO:0014805 biolink:NamedThing smooth muscle adaptation Any process in which smooth muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities. RBO_relaxed.owl GO:0014887 biolink:NamedThing cardiac muscle adaptation The process in which cardiac muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. RBO_relaxed.owl GO:0014888 biolink:NamedThing striated muscle adaptation Any process in which striated muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities. RBO_relaxed.owl GO:0014821 biolink:NamedThing phasic smooth muscle contraction A process in which force is generated within phasic smooth muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the phasic smooth muscle, the muscle contraction occurs without an ordered sarcomeric structure. Phasic smooth muscle contraction occurs in a series of discrete contractions and relaxations. RBO_relaxed.owl GO:0014831 biolink:NamedThing gastro-intestinal system smooth muscle contraction A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the gastro-intestinal system. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The gastro-intestinal system generally refers to the digestive structures stretching from the mouth to anus, but does not include the accessory glandular organs (liver, pancreas and biliary tract). RBO_relaxed.owl GO:1990765 biolink:NamedThing colon smooth muscle contraction A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry of the large intestine, exclusive of the rectum. The colon is that part of the large intestine that connects the small intestine to the rectum. RBO_relaxed.owl GO:1990770 biolink:NamedThing small intestine smooth muscle contraction A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry in the intestine between the stomach and the large intestine. RBO_relaxed.owl GO:0014827 biolink:NamedThing intestine smooth muscle contraction A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the intestine. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The intestine is the section of the alimentary canal from the stomach to the anal canal. It includes the large intestine and small intestine. RBO_relaxed.owl GO:0030432 biolink:NamedThing peristalsis A wavelike sequence of involuntary muscular contraction and relaxation that passes along a tubelike structure, such as the intestine, impelling the contents onwards. RBO_relaxed.owl GO:0014852 biolink:NamedThing regulation of skeletal muscle contraction by neural stimulation via neuromuscular junction Any process that modulates the frequency, rate or extent of skeletal muscle contraction by variation of the pattern of stimulation by nervous system. RBO_relaxed.owl GO:0014878 biolink:NamedThing response to electrical stimulus involved in regulation of muscle adaptation Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electrical stimulus. This process occurs as part of the regulation of muscle adaptation. RBO_relaxed.owl GO:0014879 biolink:NamedThing detection of electrical stimulus involved in regulation of muscle adaptation The series of events by which an electrical stimulus is received and converted into a molecular signal. This occurs as part of the regulation of muscle adaptation. RBO_relaxed.owl GO:0050963 biolink:NamedThing detection of electrical stimulus involved in sensory perception The series of events in which an electrical stimulus is received by a cell and converted into a molecular signal as part of sensory perception. RBO_relaxed.owl GO:0050964 biolink:NamedThing detection of electrical stimulus involved in electroception The series of events that contribute to electroception in which an electrical stimulus is received and converted into a molecular signal. RBO_relaxed.owl GO:0050967 biolink:NamedThing detection of electrical stimulus involved in sensory perception of pain The series of events that contribute to the perception of pain in which an electrical stimulus is received and converted into a molecular signal. RBO_relaxed.owl GO:0061951 biolink:NamedThing establishment of protein localization to plasma membrane The directed movement of a protein to a specific location in a plasma membrane. RBO_relaxed.owl GO:0070199 biolink:NamedThing establishment of protein localization to chromosome The directed movement of a protein to a specific location on a chromosome. RBO_relaxed.owl GO:0071169 biolink:NamedThing establishment of protein localization to chromatin The directed movement of a protein to a part of a chromosome that is organized into chromatin. RBO_relaxed.owl GO:0072594 biolink:NamedThing establishment of protein localization to organelle The directed movement of a protein to a specific location on or in an organelle. Encompasses establishment of localization in the membrane or lumen of a membrane-bounded organelle. RBO_relaxed.owl GO:0072666 biolink:NamedThing establishment of protein localization to vacuole The directed movement of a protein to a specific location in a vacuole. RBO_relaxed.owl GO:0090150 biolink:NamedThing establishment of protein localization to membrane The directed movement of a protein to a specific location in a membrane. RBO_relaxed.owl GO:0051119 biolink:NamedThing sugar transmembrane transporter activity Enables the transfer of a sugar from one side of a membrane to the other. A sugar is any member of a class of sweet, water-soluble, crystallizable carbohydrates, which are the monosaccharides and smaller oligosaccharides. RBO_relaxed.owl GO:0015629 biolink:NamedThing actin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. RBO_relaxed.owl GO:0015630 biolink:NamedThing microtubule cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins. RBO_relaxed.owl GO:0099569 biolink:NamedThing presynaptic cytoskeleton The portion of the cytoskeleton contained within the presynapse. RBO_relaxed.owl GO:0099571 biolink:NamedThing postsynaptic cytoskeleton The portion of the cytoskeleton contained within the postsynapse. RBO_relaxed.owl GO:0044085 biolink:NamedThing cellular component biogenesis A process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component. Includes biosynthesis of constituent macromolecules, and those macromolecular modifications that are involved in synthesis or assembly of the cellular component. RBO_relaxed.owl GO:0016301 biolink:NamedThing kinase activity Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. RBO_relaxed.owl GO:0016772 biolink:NamedThing transferase activity, transferring phosphorus-containing groups Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). RBO_relaxed.owl GO:0016310 biolink:NamedThing phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. RBO_relaxed.owl GO:0016740 biolink:NamedThing transferase activity Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. RBO_relaxed.owl GO:0016787 biolink:NamedThing hydrolase activity Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. RBO_relaxed.owl GO:0140096 biolink:NamedThing catalytic activity, acting on a protein Catalytic activity that acts to modify a protein. RBO_relaxed.owl GO:0140098 biolink:NamedThing catalytic activity, acting on RNA Catalytic activity that acts to modify RNA, driven by ATP hydrolysis. RBO_relaxed.owl GO:0140103 biolink:NamedThing catalytic activity, acting on a glycoprotein Catalysis of a biochemical reaction at physiological temperatures in which one of the substrates is a glycoprotein. RBO_relaxed.owl GO:0140640 biolink:NamedThing catalytic activity, acting on a nucleic acid Catalytic activity that acts to modify a nucleic acid. RBO_relaxed.owl GO:0017085 biolink:NamedThing response to insecticide Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insecticide stimulus. Insecticides are chemicals used to kill insects. RBO_relaxed.owl GO:0017126 biolink:NamedThing nucleologenesis A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a nucleolus, a small, dense body one or more of which are present in the nucleus of eukaryotic cells. RBO_relaxed.owl GO:0022613 biolink:NamedThing ribonucleoprotein complex biogenesis A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a complex containing RNA and proteins. Includes the biosynthesis of the constituent RNA and protein molecules, and those macromolecular modifications that are involved in synthesis or assembly of the ribonucleoprotein complex. RBO_relaxed.owl GO:0044091 biolink:NamedThing membrane biogenesis A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a membrane. RBO_relaxed.owl GO:0101025 biolink:NamedThing nuclear membrane biogenesis The process in which a nuclear membrane is synthesized, aggregates, and bonds together. RBO_relaxed.owl GO:0140112 biolink:NamedThing extracellular vesicle biogenesis The assembly and secretion a set of components to form an extracellular vesicule, a membrane-bounded vesicle that is released into the extracellular region. Extracellular vesicles include exosomes, microvesicles and apoptotic bodies, based on the mechanism by which they are released from cells and differentiated based on their size and content. RBO_relaxed.owl GO:0019228 biolink:NamedThing neuronal action potential An action potential that occurs in a neuron. RBO_relaxed.owl GO:0086001 biolink:NamedThing cardiac muscle cell action potential An action potential that occurs in a cardiac muscle cell. RBO_relaxed.owl GO:0086015 biolink:NamedThing SA node cell action potential An action potential that occurs in a sinoatrial node cardiac muscle cell. RBO_relaxed.owl GO:0086016 biolink:NamedThing AV node cell action potential An action potential that occurs in an atrioventricular node cardiac muscle cell. RBO_relaxed.owl GO:0086017 biolink:NamedThing Purkinje myocyte action potential An action potential that occurs in a Purkinje myocyte. RBO_relaxed.owl GO:0100001 biolink:NamedThing regulation of skeletal muscle contraction by action potential Any action potential process that regulates skeletal muscle contraction. RBO_relaxed.owl GO:0019725 biolink:NamedThing cellular homeostasis Any process involved in the maintenance of an internal steady state at the level of the cell. RBO_relaxed.owl GO:0019953 biolink:NamedThing sexual reproduction A type of reproduction that combines the genetic material of two gametes (such as a sperm or egg cell or fungal spores). The gametes have an haploid genome (with a single set of chromosomes, the product of a meiotic division) and combines with one another to produce a zygote (diploid). RBO_relaxed.owl GO:0022009 biolink:NamedThing central nervous system vasculogenesis The differentiation of endothelial cells from progenitor cells during blood vessel development, and the de novo formation of blood vessels and tubes in the central nervous system. The capillary endothelial cells in the brain are specialized to form the blood-brain barrier. RBO_relaxed.owl GO:0060979 biolink:NamedThing vasculogenesis involved in coronary vascular morphogenesis The differentiation of endothelial cells from progenitor cells that contributes to blood vessel development in the heart, and the de novo formation of blood vessels and tubes. RBO_relaxed.owl GO:0061148 biolink:NamedThing extracellular matrix organization involved in endocardium development A process which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix of the endocardium. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers. RBO_relaxed.owl GO:0051258 biolink:NamedThing protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. RBO_relaxed.owl GO:0023019 biolink:NamedThing signal transduction involved in regulation of gene expression Any process that modulates the frequency, rate or extent of gene expression as a consequence of a process in which a signal is released and/or conveyed from one location to another. RBO_relaxed.owl GO:0035556 biolink:NamedThing intracellular signal transduction The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell. RBO_relaxed.owl GO:0097190 biolink:NamedThing apoptotic signaling pathway The series of molecular signals which triggers the apoptotic death of a cell. The pathway starts with reception of a signal, and ends when the execution phase of apoptosis is triggered. RBO_relaxed.owl GO:0098926 biolink:NamedThing postsynaptic signal transduction Signal transduction in which the initial step occurs in a postsynapse. RBO_relaxed.owl GO:0098928 biolink:NamedThing presynaptic signal transduction Signal transduction in which the initial step occurs in a presynapse. RBO_relaxed.owl GO:0045196 biolink:NamedThing establishment or maintenance of neuroblast polarity Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of a neuroblast cell, a progenitor of the central nervous system. RBO_relaxed.owl GO:0030016 biolink:NamedThing myofibril The contractile element of skeletal and cardiac muscle; a long, highly organized bundle of actin, myosin, and other proteins that contracts by a sliding filament mechanism. RBO_relaxed.owl GO:0030485 biolink:NamedThing smooth muscle contractile fiber The contractile fiber of smooth muscle cells. RBO_relaxed.owl GO:0030048 biolink:NamedThing actin filament-based movement Movement of organelles or other particles along actin filaments, or sliding of actin filaments past each other, mediated by motor proteins. RBO_relaxed.owl GO:0031022 biolink:NamedThing nuclear migration along microfilament The directed movement of the nucleus along microfilaments within the cell, mediated by motor proteins. RBO_relaxed.owl GO:0060986 biolink:NamedThing endocrine hormone secretion The regulated release of a hormone into the circulatory system. RBO_relaxed.owl GO:0030141 biolink:NamedThing secretory granule A small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. Secretory granules move towards the periphery of the cell and upon stimulation, their membranes fuse with the cell membrane, and their protein load is exteriorized. Processing of the contained protein may take place in secretory granules. RBO_relaxed.owl GO:0070382 biolink:NamedThing exocytic vesicle A transport vesicle that mediates transport from an intracellular compartment to the plasma membrane, and fuses with the plasma membrane to release various cargo molecules, such as proteins or hormones, by exocytosis. RBO_relaxed.owl GO:0030262 biolink:NamedThing apoptotic nuclear changes Alterations undergone by nuclei at the molecular and morphological level as part of the execution phase of apoptosis. RBO_relaxed.owl GO:0140734 biolink:NamedThing ammonium excretion The elimination of ammonium ions from an excretory cell. RBO_relaxed.owl GO:0030473 biolink:NamedThing nuclear migration along microtubule The directed movement of the nucleus along microtubules within the cell, mediated by motor proteins. RBO_relaxed.owl GO:0035190 biolink:NamedThing syncytial nuclear migration The directed movement of nuclei within the syncytial embryo of insects. These precise temporal and spatial patterns of nuclear movement are coordinated with mitotic divisons and are required during blastoderm formation to reposition dividing nuclei from the interior of the syncytial embryo to the cortex. RBO_relaxed.owl GO:0031076 biolink:NamedThing embryonic camera-type eye development The process occurring during the embryonic phase whose specific outcome is the progression of the eye over time, from its formation to the mature structure. RBO_relaxed.owl GO:0031012 biolink:NamedThing extracellular matrix A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues. RBO_relaxed.owl GO:0031045 biolink:NamedThing dense core granule Electron-dense organelle with a granular internal matrix; contains proteins destined to be secreted. RBO_relaxed.owl GO:0042588 biolink:NamedThing zymogen granule A membrane-bounded, cytoplasmic secretory granule found in enzyme-secreting cells and visible by light microscopy. Contain zymogen, an inactive enzyme precursor, often of a digestive enzyme. RBO_relaxed.owl GO:0031175 biolink:NamedThing neuron projection development The process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites). RBO_relaxed.owl GO:0097060 biolink:NamedThing synaptic membrane A specialized area of membrane on either the presynaptic or the postsynaptic side of a synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell. RBO_relaxed.owl GO:1903561 biolink:NamedThing extracellular vesicle Any vesicle that is part of the extracellular region. RBO_relaxed.owl GO:0031594 biolink:NamedThing neuromuscular junction The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential. RBO_relaxed.owl GO:0045202 biolink:NamedThing synapse The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane. RBO_relaxed.owl GO:0098523 biolink:NamedThing neuromuscular junction of myotube A neuromuscular junction in which the target muscle cell is a myotube. RBO_relaxed.owl GO:0098981 biolink:NamedThing cholinergic synapse A synapse that uses acetylcholine as a neurotransmitter. RBO_relaxed.owl GO:0031987 biolink:NamedThing locomotion involved in locomotory behavior Self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement. RBO_relaxed.owl GO:0099170 biolink:NamedThing postsynaptic modulation of chemical synaptic transmission Any process, acting in the postsynapse that results in modulation of chemical synaptic transmission. RBO_relaxed.owl GO:0099171 biolink:NamedThing presynaptic modulation of chemical synaptic transmission Any process, acting in the presynapse that results in modulation of chemical synaptic transmission. RBO_relaxed.owl GO:0099550 biolink:NamedThing trans-synaptic signaling, modulating synaptic transmission Cell-cell signaling between presynapse and postsynapse, across the synaptic cleft, that modulates the synaptic transmission properties of the synapse. RBO_relaxed.owl GO:0099738 biolink:NamedThing cell cortex region The complete extent of cell cortex that underlies some some region of the plasma membrane. RBO_relaxed.owl GO:0048066 biolink:NamedThing developmental pigmentation The developmental process that results in the deposition of coloring matter in an organism, tissue or cell. RBO_relaxed.owl GO:0033365 biolink:NamedThing protein localization to organelle A process in which a protein is transported to, or maintained in, a location within an organelle. RBO_relaxed.owl GO:0033366 biolink:NamedThing protein localization to secretory granule A process in which a protein is transported to, or maintained in, a location within a secretory granule. RBO_relaxed.owl GO:0034067 biolink:NamedThing protein localization to Golgi apparatus A process in which a protein is transported to, or maintained in, a location within the Golgi apparatus. RBO_relaxed.owl GO:0034502 biolink:NamedThing protein localization to chromosome Any process in which a protein is transported to, or maintained at, a specific location on a chromosome. RBO_relaxed.owl GO:0034504 biolink:NamedThing protein localization to nucleus A process in which a protein transports or maintains the localization of another protein to the nucleus. RBO_relaxed.owl GO:0035372 biolink:NamedThing protein localization to microtubule A process in which a protein is transported to, or maintained at, a microtubule. RBO_relaxed.owl GO:0035418 biolink:NamedThing protein localization to synapse Any process in which a protein is transported to, and/or maintained at the synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell. RBO_relaxed.owl GO:0044380 biolink:NamedThing protein localization to cytoskeleton A process in which a protein is transported to, or maintained in, a location within the cytoskeleton. RBO_relaxed.owl GO:0061512 biolink:NamedThing protein localization to cilium A process in which a protein is transported to, or maintained in, a location within a cilium. RBO_relaxed.owl GO:0061938 biolink:NamedThing protein localization to somatodendritic compartment A process in which a protein is transported to or maintained in a location within the somatodendritic compartment. RBO_relaxed.owl GO:0062237 biolink:NamedThing protein localization to postsynapse Any process in which a protein is transported to, and/or maintained at the postsynapse, the part of a synapse that is part of the post-synaptic cell. RBO_relaxed.owl GO:0071168 biolink:NamedThing protein localization to chromatin Any process in which a protein is transported to, or maintained at, a part of a chromosome that is organized into chromatin. RBO_relaxed.owl GO:0071692 biolink:NamedThing protein localization to extracellular region Any process in which a protein is transported from one specific location in the extracellular region to another, or maintained in a specific extracellular location. RBO_relaxed.owl GO:0072657 biolink:NamedThing protein localization to membrane A process in which a protein is transported to, or maintained in, a specific location in a membrane. RBO_relaxed.owl GO:0072659 biolink:NamedThing protein localization to plasma membrane A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane. RBO_relaxed.owl GO:0072665 biolink:NamedThing protein localization to vacuole A process in which a protein is transported to, or maintained at, a location in a vacuole. RBO_relaxed.owl GO:0072697 biolink:NamedThing protein localization to cell cortex A process in which a protein is transported to, or maintained in, the cell cortex. RBO_relaxed.owl GO:0072698 biolink:NamedThing protein localization to microtubule cytoskeleton A cellular protein localization process in which a protein is transported to, or maintained at, a location within the microtubule cytoskeleton. RBO_relaxed.owl GO:0090435 biolink:NamedThing protein localization to nuclear envelope A process in which a protein is transported to, or maintained at, a location within a nuclear envelope. RBO_relaxed.owl GO:0097355 biolink:NamedThing protein localization to heterochromatin Any process in which a protein is transported to, or maintained at, a part of a chromosome that is organized into heterochromatin. RBO_relaxed.owl GO:0150105 biolink:NamedThing protein localization to cell-cell junction A process in which a protein is transported to, or maintained, in a location within a cell-cell junction. RBO_relaxed.owl GO:1902414 biolink:NamedThing protein localization to cell junction A process in which a protein is transported to, or maintained in, a location within a cell junction. RBO_relaxed.owl GO:1902463 biolink:NamedThing protein localization to cell leading edge A process in which a protein is transported to, or maintained in, a location within a cell leading edge. RBO_relaxed.owl GO:1902570 biolink:NamedThing protein localization to nucleolus A process in which a protein is transported to, or maintained in, a location within a nucleolus. RBO_relaxed.owl GO:1903119 biolink:NamedThing protein localization to actin cytoskeleton A process in which a protein is transported to, or maintained in, the location of an actin cytoskeleton. RBO_relaxed.owl GO:1903120 biolink:NamedThing protein localization to actin filament bundle A process in which a protein is transported to, or maintained in, the location of an actin filament bundle. RBO_relaxed.owl GO:1903292 biolink:NamedThing protein localization to Golgi membrane A process in which a protein is transported to, or maintained in, a location within a Golgi membrane. RBO_relaxed.owl GO:1903441 biolink:NamedThing protein localization to ciliary membrane A process in which a protein is transported to, or maintained in, a location within a ciliary membrane. RBO_relaxed.owl GO:1903778 biolink:NamedThing protein localization to vacuolar membrane A process in which a protein is transported to, or maintained in, a location within a vacuolar membrane. RBO_relaxed.owl GO:1904106 biolink:NamedThing protein localization to microvillus A process in which a protein is transported to, or maintained in, a location within a microvillus. RBO_relaxed.owl GO:1904491 biolink:NamedThing protein localization to ciliary transition zone A process in which a protein is transported to, or maintained in, a location within a ciliary transition zone. RBO_relaxed.owl GO:1905383 biolink:NamedThing protein localization to presynapse A process in which a protein is transported to, or maintained in, a location within a presynapse. RBO_relaxed.owl GO:1905755 biolink:NamedThing protein localization to cytoplasmic microtubule A process in which a protein is transported to, or maintained in, a location within a cytoplasmic microtubule. RBO_relaxed.owl GO:1990778 biolink:NamedThing protein localization to cell periphery A process in which a protein is transported to, or maintained in, the cell periphery. RBO_relaxed.owl GO:0104004 biolink:NamedThing cellular response to environmental stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an environmental stimulus. RBO_relaxed.owl OBO:RBO_00005067 biolink:NamedThing indirect cellular response to stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus which acts on another cell and not on the responding cell. The process begins with detection of the stimulus by a cell and ends with a change in state or activity of a different cell RBO_relaxed.owl GO:0140056 biolink:NamedThing organelle localization by membrane tethering The process by which an organelle membrane interacts with another membrane via molecular tethers that physically bridge the two membranes and attach them to each other. RBO_relaxed.owl GO:1902358 biolink:NamedThing sulfate transmembrane transport The directed movement of sulfate across a membrane. RBO_relaxed.owl GO:0046666 biolink:NamedThing retinal cell programmed cell death Programmed cell death that occurs in the developing retina. RBO_relaxed.owl GO:0035735 biolink:NamedThing intraciliary transport involved in cilium assembly The bidirectional movement of large protein complexes along microtubules within a cilium that contributes to cilium assembly. RBO_relaxed.owl GO:0035805 biolink:NamedThing egg coat A specialized extracellular matrix that surrounds the plasma membrane of the ovum of animals. The egg coat provides structural support and can play an essential role in oogenesis, fertilization and early development. RBO_relaxed.owl GO:0035861 biolink:NamedThing site of double-strand break A region of a chromosome at which a DNA double-strand break has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix. RBO_relaxed.owl GO:0035935 biolink:NamedThing androgen secretion The regulated release of an androgen into the circulatory system. Androgens are steroid hormones that stimulate or control the development and maintenance of masculine characteristics in vertebrates. RBO_relaxed.owl GO:0043931 biolink:NamedThing ossification involved in bone maturation The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone, involved in the progression of the skeleton from its formation to its mature state. RBO_relaxed.owl GO:0048699 biolink:NamedThing generation of neurons The process in which nerve cells are generated. This includes the production of neuroblasts and their differentiation into neurons. RBO_relaxed.owl GO:0099575 biolink:NamedThing regulation of protein catabolic process at presynapse, modulating synaptic transmission Any process that modulates synaptic transmission by regulating a catabolic process occurring at a presynapse. RBO_relaxed.owl GO:0099576 biolink:NamedThing regulation of protein catabolic process at postsynapse, modulating synaptic transmission Any process that modulates synaptic transmission by regulating a catabolic process occurring at a postsynapse. RBO_relaxed.owl GO:0042254 biolink:NamedThing ribosome biogenesis A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis. RBO_relaxed.owl GO:0042402 biolink:NamedThing cellular biogenic amine catabolic process The chemical reactions and pathways occurring at the level of individual cells resulting in the breakdown of biogenic amines, any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters. RBO_relaxed.owl GO:0043025 biolink:NamedThing neuronal cell body The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites. RBO_relaxed.owl GO:0043228 biolink:NamedThing non-membrane-bounded organelle Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes. RBO_relaxed.owl GO:0043229 biolink:NamedThing intracellular organelle Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane. RBO_relaxed.owl GO:0043230 biolink:NamedThing extracellular organelle Organized structure of distinctive morphology and function, occurring outside the cell. Includes, for example, extracellular membrane vesicles (EMVs) and the cellulosomes of anaerobic bacteria and fungi. RBO_relaxed.owl GO:0043264 biolink:NamedThing extracellular non-membrane-bounded organelle Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring outside the cell. RBO_relaxed.owl GO:0099512 biolink:NamedThing supramolecular fiber A polymer consisting of an indefinite number of protein or protein complex subunits that have polymerised to form a fiber-shaped structure. RBO_relaxed.owl GO:0071953 biolink:NamedThing elastic fiber An supramolecular fiber that consists of an insoluble core of polymerized tropoelastin monomers and a surrounding mantle of microfibrils. Elastic fibers provide elasticity and recoiling to tissues and organs, and maintain structural integrity against mechanical strain. RBO_relaxed.owl GO:0098643 biolink:NamedThing banded collagen fibril A supramolecular assembly of fibrillar collagen complexes in the form of a long fiber (fibril) with transverse striations (bands). RBO_relaxed.owl GO:0044207 biolink:NamedThing translation initiation ternary complex A ribonucleoprotein complex that contains aminoacylated initiator methionine tRNA, GTP, and initiation factor 2 (either eIF2 in eukaryotes, or IF2 in prokaryotes). In prokaryotes, fMet-tRNA (initiator) is used rather than Met-tRNA (initiator). RBO_relaxed.owl GO:0046545 biolink:NamedThing development of primary female sexual characteristics The process whose specific outcome is the progression of the primary female sexual characteristics over time, from their formation to the mature structure. The primary female sexual characteristics are the ovaries, and they develop in response to sex hormone secretion. RBO_relaxed.owl GO:0046660 biolink:NamedThing female sex differentiation The establishment of the sex of a female organism by physical differentiation. RBO_relaxed.owl GO:0046667 biolink:NamedThing compound eye retinal cell programmed cell death Programmed cell death that occurs in the retina to remove excess cells between ommatidia, thus resulting in a hexagonal lattice, precise with respect to cell number and position surrounding each ommatidium. RBO_relaxed.owl GO:0046716 biolink:NamedThing muscle cell cellular homeostasis The cellular homeostatic process that preserves a muscle cell in a stable functional or structural state. RBO_relaxed.owl GO:0070050 biolink:NamedThing neuron cellular homeostasis The cellular homeostatic process that preserves a neuron in a stable, differentiated functional and structural state. RBO_relaxed.owl GO:0048199 biolink:NamedThing vesicle targeting, to, from or within Golgi The process in which vesicles are directed to specific destination membranes during transport to, from or within the Golgi apparatus; mediated by the addition of specific coat proteins, including COPI and COPII proteins and clathrin, to the membrane during vesicle formation. RBO_relaxed.owl GO:0048288 biolink:NamedThing nuclear membrane fusion involved in karyogamy The joining of 2 or more lipid bilayer membranes that surround the nucleus during the creation of a single nucleus from multiple nuclei. RBO_relaxed.owl GO:0048596 biolink:NamedThing embryonic camera-type eye morphogenesis The process in which the anatomical structures of the eye are generated and organized during embryonic development. RBO_relaxed.owl GO:0048755 biolink:NamedThing branching morphogenesis of a nerve The process in which the anatomical structures of branches in a nerve are generated and organized. This term refers to an anatomical structure (nerve) not a cell (neuron). RBO_relaxed.owl GO:0061114 biolink:NamedThing branching involved in pancreas morphogenesis The process in which the branches of the pancreas are generated and organized. RBO_relaxed.owl GO:0050881 biolink:NamedThing musculoskeletal movement The movement of an organism or part of an organism using mechanoreceptors, the nervous system, striated muscle and/or the skeletal system. RBO_relaxed.owl GO:0050956 biolink:NamedThing electroception The series of events required for an organism to receive an electrical stimulus, convert it to a molecular signal, and recognize and characterize the signal. Many fish possess an electroception sense; for example, the electric eel uses low voltage pulses of electricity for navigation and prey location. RBO_relaxed.owl GO:0051410 biolink:NamedThing detoxification of nitrogen compound Any process that reduces or removes the toxicity of nitrogenous compounds which are dangerous or toxic. This includes the aerobic conversion of toxic compounds to harmless substances. RBO_relaxed.owl GO:0061687 biolink:NamedThing detoxification of inorganic compound Any process that reduces or removes the toxicity of inorganic compounds. These include transport of such compounds away from sensitive areas and to compartments or complexes whose purpose is sequestration of inorganic compounds. RBO_relaxed.owl UBERON:0002350 biolink:NamedThing conducting system of heart The cardiac conduction system consists of specialized cardiomyocytes that regulate the frequency of heart beat[GO]. RBO_relaxed.owl UBERON:0002108 biolink:NamedThing small intestine Subdivision of digestive tract that connects the stomach to the large intestine and is where much of the digestion and absorption of food takes place (with the exception of ruminants). The mammalian small intestine is long and coiled and can be differentiated histologically into: duodenum, jejunem, ileum[WP,cjm,Kardong]. RBO_relaxed.owl UBERON:0001242 biolink:NamedThing intestinal mucosa Mucosal layer that lines the intestine. RBO_relaxed.owl UBERON:0000020 biolink:NamedThing sense organ An organ that is capable of transducing sensory stimulus to the nervous system. RBO_relaxed.owl UBERON:0003354 biolink:NamedThing epithelium of rectum An epithelium that is part of a rectum [Automatically generated definition]. RBO_relaxed.owl UBERON:0018649 biolink:NamedThing cardiac muscle tissue of ventricle RBO_relaxed.owl N12086f86979e480ba14c7a3ad43ea058 biolink:NamedThing RBO_relaxed.owl N2f7740eecd8e4e0299eb47500aa0d3ac biolink:NamedThing RBO_relaxed.owl NCBITaxon:33208 biolink:NamedThing Metazoa RBO_relaxed.owl Nf42348587c1146019522edc09341eee8 biolink:NamedThing RBO_relaxed.owl UBERON:0002530 biolink:NamedThing gland An organ that functions as a secretory or excretory organ. RBO_relaxed.owl UBERON:0000924 biolink:NamedThing ectoderm Primary germ layer that is the outer of the embryo's three germ layers and gives rise to epidermis and neural tissue. RBO_relaxed.owl owl:Thing biolink:NamedThing RBO_relaxed.owl UBERON:0001134 biolink:NamedThing skeletal muscle tissue Muscle tissue that consists primarily of skeletal muscle fibers. RBO_relaxed.owl UBERON:0000468 biolink:NamedThing multicellular organism Anatomical structure that is an individual member of a species and consists of more than one cell. RBO_relaxed.owl Nd84b84034024459ab757c06a42c54621 biolink:NamedThing RBO_relaxed.owl IAO:0000100 biolink:NamedThing data set A data item that is an aggregate of other data items of the same type that have something in common. Averages and distributions can be determined for data sets. RBO_relaxed.owl N1b644cd08b144c79b325809842d36bf8 biolink:NamedThing RBO_relaxed.owl Nc36e39d43be249dfb1355f0416aab21d biolink:NamedThing RBO_relaxed.owl UBERON:0002106 biolink:NamedThing spleen The organ that functions to filter blood and to store red corpuscles and platelets. RBO_relaxed.owl UBERON:0008339 biolink:NamedThing microvascular endothelium RBO_relaxed.owl UBERON:0002081 biolink:NamedThing cardiac atrium Cardiac chamber in which blood enters the heart. RBO_relaxed.owl UBERON:0001891 biolink:NamedThing midbrain The midbrain is the middle division of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes a ventral part containing the cerebral peduncles and a dorsal tectum containing the corpora quadrigemina and that surrounds the aqueduct of Sylvius connecting the third and fourth ventricles)[GO]. RBO_relaxed.owl PR:000001020 biolink:NamedThing CD3 epsilon A CD3 subunit with immunoglobulin domain that is a translation product of the human CD3E gene or a 1:1 ortholog thereof. RBO_relaxed.owl UBERON:0003902 biolink:NamedThing retinal neural layer The part of the retina that contains neurons and photoreceptor cells[GO]. RBO_relaxed.owl UBERON:0000010 biolink:NamedThing peripheral nervous system A major division of the nervous system that contains nerves which connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands. RBO_relaxed.owl UBERON:0002094 biolink:NamedThing interventricular septum Cardiac septum which separates the right ventricle from the left ventricle.[FMA]. RBO_relaxed.owl NCBITaxon:7742 biolink:NamedThing Vertebrata RBO_relaxed.owl N5186c72376734a878a1f7a84fd1bf370 biolink:NamedThing RBO_relaxed.owl PATO:0001429 biolink:NamedThing acidic An medium acidity quality inhering in a solution by virtue of the bearer's a high concentration of H+ ions. RBO_relaxed.owl UBERON:0000018 biolink:NamedThing compound eye A light sensing organ composed of ommatidia. RBO_relaxed.owl UBERON:0013697 biolink:NamedThing exocrine pancreas epithelium Epithelium lining the exocrine pancreas. RBO_relaxed.owl Na169959560404a36bb0c9efd82389458 biolink:NamedThing RBO_relaxed.owl UBERON:0003942 biolink:NamedThing somatosensory system The sensory system for the sense of touch and pain. RBO_relaxed.owl N45ee0f0ba6f2443bbc28fe7728e95011 biolink:NamedThing RBO_relaxed.owl N1268fefe5238417d99558d0c0cc054b1 biolink:NamedThing RBO_relaxed.owl Nd5666a90e9ab43e1b0f2088254fe0c3d biolink:NamedThing RBO_relaxed.owl N21c5173bf7504e02be2193ca7183bf34 biolink:NamedThing RBO_relaxed.owl Ne4d1c2d5e46849628fa9b36397bcbffa biolink:NamedThing RBO_relaxed.owl UBERON:0000059 biolink:NamedThing large intestine A subdivision of the digestive tract that connects the small intestine to the cloaca or anus. Lacks or has few villi[Kardong]. RBO_relaxed.owl UBERON:0000945 biolink:NamedThing stomach An expanded region of the vertebrate alimentary tract that serves as a food storage compartment and digestive organ. A stomach is lined, in whole or in part by a glandular epithelium. RBO_relaxed.owl UBERON:0001135 biolink:NamedThing smooth muscle tissue Muscle tissue which is unstriated, composed primarily of smooth muscle fibers surrounded by a reticulum of collagen and elastic fibers. Smooth muscle differs from striated muscle in the much higher actin/myosin ratio, the absence of conspicuous sarcomeres and the ability to contract to a much smaller fraction of its resting length[GO]. RBO_relaxed.owl UBERON:0002114 biolink:NamedThing duodenum The first part of the small intestine. At the junction of the stomach and the duodenum the alimentary canal is inflected. The duodenum first goes anteriorly for a short distance, turns dorsally, and eventually caudally, thus it is a U-shaped structure with two horizontal sections (a ventral and a dorsal one). RBO_relaxed.owl UBERON:0001976 biolink:NamedThing epithelium of esophagus The epithelial layer that lines the luminal space of the esophagus. RBO_relaxed.owl UBERON:0000925 biolink:NamedThing endoderm Primary germ layer that lies remote from the surface of the embryo and gives rise to internal tissues such as gut. RBO_relaxed.owl Nb1506c7ebd9b45cc88e9b34ffc06d961 biolink:NamedThing RBO_relaxed.owl UBERON:0000160 biolink:NamedThing intestine Segment of the alimentary canal extending from the stomach to the anus and, in humans and other mammals, consists of two segments, the small intestine and the large intestine. RBO_relaxed.owl NCBITaxon:131567 biolink:NamedThing cellular organisms RBO_relaxed.owl UBERON:0004490 biolink:NamedThing cardiac muscle tissue of atrium A portion of cardiac muscle tissue that is part of an atrium [Automatically generated definition]. RBO_relaxed.owl UBERON:0001041 biolink:NamedThing foregut Anterior subdivision of a digestive tract. RBO_relaxed.owl N610e9c1e79704a6cb61f5f1ad190008b biolink:NamedThing RBO_relaxed.owl UBERON:0002165 biolink:NamedThing endocardium The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers[GO]. RBO_relaxed.owl Nf88ca07ba266429ebeeeb6a3c1899157 biolink:NamedThing RBO_relaxed.owl UBERON:0002148 biolink:NamedThing locus ceruleus The locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic[GO]. Bluish region in the superior angle of the fourth ventricle floor, corresponding to melanin-like pigmented nerve cells which lie lateral to the ponto-mesencephalic central gray (griseum centrale). It is also known as nucleus pigmentosus pontis[GAID]. RBO_relaxed.owl UBERON:0004146 biolink:NamedThing His-Purkinje system The His-Purkinje system receives signals from the AV node and is composed of the fibers that regulate cardiac muscle contraction in the ventricles. RBO_relaxed.owl UBERON:0002082 biolink:NamedThing cardiac ventricle Cardiac chamber through which blood leaves the heart. RBO_relaxed.owl PATO:0001400 biolink:NamedThing unipotent A cellular potency that is the capacity to produce only one differentiated cell type. RBO_relaxed.owl PR:000001024 biolink:NamedThing neural cell adhesion molecule 1 A neural cell adhesion molecule NCAM that is a translation product of the human NCAM1 gene or a 1:1 ortholog thereof. RBO_relaxed.owl NCBITaxon:32525 biolink:NamedThing Theria RBO_relaxed.owl N9a5836917f054caa886b3c3f5d6b49d0 biolink:NamedThing RBO_relaxed.owl UBERON:0001155 biolink:NamedThing colon A portion of the large intestine before it becomes the rectum. In mammals, the colon is the most part of the large intestine, excluding the vermiform appendix, the rectum and the anal canal. RBO_relaxed.owl UBERON:0002410 biolink:NamedThing autonomic nervous system The autonomic nervous system is composed of neurons that are not under conscious control, and is comprised of two antagonistic components, the sympathetic and parasympathetic nervous systems. The autonomic nervous system regulates key functions including the activity of the cardiac (heart) muscle, smooth muscles (e.g. of the gut), and glands[GO]. RBO_relaxed.owl PR:000002978 biolink:NamedThing lymphocyte antigen 6G An Ly-6-like protein that is a translation product of the mouse Ly6g gene or a 1:1 ortholog thereof. RBO_relaxed.owl UBERON:0002078 biolink:NamedThing right cardiac atrium A cardiac atrium that is in the right side of the heart. It receives deoxygenated blood. In mammals, this comes from the superior and inferior vena cava and the coronary sinus, and pumps it into the right ventricle through the tricuspid valve. RBO_relaxed.owl UBERON:0002352 biolink:NamedThing atrioventricular node An area of conducting tissue between the atria and the ventricles of the heart that conducts the normal electrical impulse from the atria to the ventricles. RBO_relaxed.owl N63eefb204fff40ea9b9eef0e78fd2ddb biolink:NamedThing RBO_relaxed.owl UBERON:0000988 biolink:NamedThing pons The part of the central nervous system lying between the medulla oblongata and the midbrain, ventral to the cerebellum. RBO_relaxed.owl Ndef3d90b75c643f09f1be3389669927a biolink:NamedThing RBO_relaxed.owl UBERON:0003075 biolink:NamedThing neural plate A region of embryonic ectodermal cells that lie directly above the notochord. During neurulation, they change shape and produce an infolding of the neural plate (the neural fold) that then seals to form the neural tube[XAO]. The earliest recognizable dorsal ectodermal primordium of the central nervous system present near the end of gastrulation before infolding to form the neural keel; consists of a thickened pseudostratified epithelium[ZFA]. RBO_relaxed.owl N071836c42ffc46ca9dce327f10300fbe biolink:NamedThing RBO_relaxed.owl NCBITaxon:2759 biolink:NamedThing Eukaryota RBO_relaxed.owl N57f84e48ea9641dabc0d3caa588e899b biolink:NamedThing RBO_relaxed.owl UBERON:0007100 biolink:NamedThing primary circulatory organ A hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood or analogs[GO,modified]. RBO_relaxed.owl UBERON:0000062 biolink:NamedThing organ Anatomical structure that performs a specific function or group of functions [WP]. RBO_relaxed.owl N25d1ef596aba45ca8351d1794b8ec833 biolink:NamedThing RBO_relaxed.owl NCBITaxon:6656 biolink:NamedThing Arthropoda RBO_relaxed.owl N6ee1e2b6e33348ac99868f45227be5ab biolink:NamedThing RBO_relaxed.owl UBERON:0001434 biolink:NamedThing skeletal system Anatomical system that is a multi-element, multi-tissue anatomical cluster that consists of the skeleton and the articular system. RBO_relaxed.owl PATO:0000386 biolink:NamedThing hard A hardness quality of being rigid and resistant to pressure. RBO_relaxed.owl PATO:0002505 biolink:NamedThing nucleated A nucleate quality inhering in a bearer by virtue of the bearer's having one or more nucleus. RBO_relaxed.owl UBERON:0002063 biolink:NamedThing sinus venosus The sinus venosus is a large cardiac chamber at the inflow tract that receives venous blood from systemic circulation. precedes the atrium on the venous side of the chordate heart. RBO_relaxed.owl UBERON:0001892 biolink:NamedThing rhombomere A segment of the developing hindbrain[ZFA]. In the vertebrate embryo, a rhombomere is a transiently divided segment of the developing neural tube, within the hindbrain region (a neuromere) in the area that will eventually become the rhombencephalon. The rhombomeres appear as a series of slightly constricted swellings in the neural tube, caudal to the cephalic flexure.[WP]. RBO_relaxed.owl UBERON:0001514 biolink:NamedThing descending aorta The descending aorta is the portion of the aorta in a two-pass circulatory system from the arch of aorta to the point where it divides into the common iliac arteries[GO]. The descending aorta is part of the aorta, the largest artery in the body. The descending aorta is the part of the aorta beginning at the aortic arch that runs down through the chest and abdomen. The descending aorta is divided into two portions, the thoracic and abdominal, in correspondence with the two great cavities of the trunk in which it is situated. Within the abdomen, the descending aorta branches into the two common iliac arteries which serve the legs. [WP,unvetted]. RBO_relaxed.owl Nd29bdd0b9fbd4cf099290f5e87be552f biolink:NamedThing RBO_relaxed.owl UBERON:0004822 biolink:NamedThing extrahepatic bile duct epithelium An epithelium that is part of a extrahepatic bile duct [Automatically generated definition]. RBO_relaxed.owl N37d7dcbdb2fa4feaa80c916c6de26a5f biolink:NamedThing RBO_relaxed.owl UBERON:0002418 biolink:NamedThing cartilage tissue Skeletal tissue that is avascular, rich in glycosaminoglycans (GAGs) and typically includes chondrocytes within isolated lacunae. Cartilage tissue is deposited by chondroblasts. RBO_relaxed.owl UBERON:0001645 biolink:NamedThing trigeminal nerve Cranial nerve that has three branches - the ophthalmic (supplying the skin of the nose and upper jaw), the maxillary and the mandibular (supplying the lower jaw). RBO_relaxed.owl UBERON:0003382 biolink:NamedThing cardiac muscle of left ventricle A portion of cardiac muscle tissue that is part of a left ventricle [Automatically generated definition]. RBO_relaxed.owl UBERON:0007247 biolink:NamedThing nucleus of superior olivary complex Any of the nuclei that comprise the superior olivary complex (superior olive). This includes both the primary nuclei such as the lateral and medial nuclei, as well as periolivary nuclei. RBO_relaxed.owl UBERON:0001277 biolink:NamedThing intestinal epithelium Epithelial layer that lines the intestine. RBO_relaxed.owl Nc8732975c2c640f58284183a1cd3f9b8 biolink:NamedThing RBO_relaxed.owl UBERON:0004142 biolink:NamedThing outflow tract septum The outflow tract septum is a partition in the outflow tract. RBO_relaxed.owl PATO:0001733 biolink:NamedThing evergreen (plant) A quality inhering in a plant by virtue of the bearer's disposition to retain foliage. RBO_relaxed.owl UBERON:0000992 biolink:NamedThing ovary The gonad of a female organism which contains germ cells. RBO_relaxed.owl N9870f3ebcd65467ebff55bf993910913 biolink:NamedThing RBO_relaxed.owl PR:000001012 biolink:NamedThing integrin alpha-M An integrin alpha with A domain that is a translation product of the human ITGAM gene or a 1:1 ortholog thereof. They constitute subunits of the integrin alpha-M/beta-2 receptor. This receptor is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is also a receptor for fibrinogen, factor X and ICAM1. RBO_relaxed.owl GO:0070483 biolink:NamedThing detection of hypoxia The series of events in which a stimulus indicating lowered oxygen tension is received by a cell and converted into a molecular signal. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level. RBO_relaxed.owl Nbae8a86eaee5455494c9b83581a81e26 biolink:NamedThing RBO_relaxed.owl UBERON:0004133 biolink:NamedThing salivatory nucleus Missing definition for term UBERON:0004133. Please replace it using linked reference. RBO_relaxed.owl UBERON:0002049 biolink:NamedThing vasculature An interconnected tubular multi-tissue structure contains fluid that is actively transported around the organism[ZFA]. Examples: vasculature of lung, vasculature of face. RBO_relaxed.owl PATO:0001548 biolink:NamedThing quality of a liquid A physical quality inhering in an entity exhibiting the physical characteristics of an amorphous (non-crystalline) form of matter between a gas and a solid that has a definite volume, but no definite shape. RBO_relaxed.owl NCBITaxon:4751 biolink:NamedThing Fungi RBO_relaxed.owl NCBITaxon:7711 biolink:NamedThing Chordata RBO_relaxed.owl UBERON:0007846 biolink:NamedThing dense regular connective tissue Connective tissue that is dominated by collagen fibres organized into a definitive pattern (e.g., parallel to one another), with comparatively fewer cells (mostly fibroblasts). RBO_relaxed.owl N17fd28a45aa7439c90ed50593b8c68a3 biolink:NamedThing RBO_relaxed.owl PATO:0001375 biolink:NamedThing haploid A ploidy quality inhering in a bearer by virtue of the bearer's containing a single set of homologous chromosomes. RBO_relaxed.owl UBERON:0002028 biolink:NamedThing hindbrain The most posterior of the three principal regions of the brain. In mammals and birds the hindbrain is divided into a rostral metencephalon and a caudal myelencephalon. In zebrafish, with the exception of the cerebellum, the ventral remainder of the metencephalon can be separated only arbitrarily from the more caudal myelencephalic portion of the medulla oblongata (From: Neuroanatomy of the Zebrafish Brain)[ZFA]. Organ component of neuraxis that has as its parts the pons, cerebellum and medulla oblongata[FMA]. RBO_relaxed.owl UBERON:0001803 biolink:NamedThing epithelium of lens A layer of epithelial cells that is part of the eye. RBO_relaxed.owl N7dd8ea35f32249799c5fa32829e26960 biolink:NamedThing RBO_relaxed.owl N03eaa4cfc72d444fb204241ba7898860 biolink:NamedThing RBO_relaxed.owl Ne706ad52a387443fba40cd38534eba3b biolink:NamedThing RBO_relaxed.owl UBERON:0000043 biolink:NamedThing tendon Dense regular connective tissue that connects muscle to bone[VSAO]. RBO_relaxed.owl UBERON:0000970 biolink:NamedThing eye An organ that detects light. RBO_relaxed.owl N911a651ef0e64b328667422517aff19a biolink:NamedThing RBO_relaxed.owl N6f53fefe582d4e5c811497d98260fb12 biolink:NamedThing RBO_relaxed.owl Naaebd0d387474ed48af323186e0f05d6 biolink:NamedThing RBO_relaxed.owl UBERON:0001032 biolink:NamedThing sensory system Anatomical system that overlaps the nervous system and is responsible for receiving and processing sensory information. RBO_relaxed.owl Na43d5d9b4775471f954077693e22e7f7 biolink:NamedThing RBO_relaxed.owl UBERON:0002149 biolink:NamedThing superior salivatory nucleus Nucleus containing parasympathetic neurons giving rise to the parasympathetic division of the facial nerve, innervating the salivary glands (Brodal, Neurological Anatomy, 3rd ed., 1981, pg 703). RBO_relaxed.owl NCBITaxon:6072 biolink:NamedThing Eumetazoa RBO_relaxed.owl N0d79e59ee9154e37b088ad834b24f316 biolink:NamedThing RBO_relaxed.owl N801dfdb26981480795c8471388bd1072 biolink:NamedThing RBO_relaxed.owl UBERON:0002036 biolink:NamedThing striated muscle tissue Muscle tissue that contains fibers that are divided by transverse bands into striations. RBO_relaxed.owl Nf06220087bb24efc90d149b5000f3a6c biolink:NamedThing RBO_relaxed.owl UBERON:0002384 biolink:NamedThing connective tissue Tissue with cells that deposit non-polarized extracellular matrix including connective tissue fibers and ground substance. RBO_relaxed.owl UBERON:0002405 biolink:NamedThing immune system Anatomical system that protects the body from foreign substances, cells, and tissues by producing the immune response and that includes especially the thymus, spleen, lymphoid tissue, lymphocytes including the B cells and T cells, and antibodies. RBO_relaxed.owl Nc525664a7c2149ceb8dd7df6fdf2877f biolink:NamedThing RBO_relaxed.owl UBERON:0001979 biolink:NamedThing venule One of the minute vessels that collect deoxygenated blood from the capillary plexuses returns it to the veins. RBO_relaxed.owl GO:0050803 biolink:NamedThing regulation of synapse structure or activity Any process that modulates the physical form or the activity of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell). RBO_relaxed.owl Nafad9d2229584178b1ae4fb3a98553d5 biolink:NamedThing RBO_relaxed.owl UBERON:0001776 biolink:NamedThing optic choroid Vascular layer containing connective tissue, of the eye lying between the retina and the sclera. The choroid provides oxygen and nourishment to the outer layers of the retina. Along with the ciliary body and iris, the choroid forms the uveal tract[WP]. RBO_relaxed.owl N4871c777e9474962bea53cc94937bc11 biolink:NamedThing RBO_relaxed.owl Nf8702d43d28f461e8b814a4b0c7011b0 biolink:NamedThing RBO_relaxed.owl N21bd8049dd494b9ea821c1f67b60b0c8 biolink:NamedThing RBO_relaxed.owl N3b67ca5abc3d444ea3857c7b17721e83 biolink:NamedThing RBO_relaxed.owl PR:000001444 biolink:NamedThing cadherin-5 A cadherin that is a translation product of the human CDH5 gene or a 1:1 ortholog thereof. RBO_relaxed.owl UBERON:0003855 biolink:NamedThing gonad mesenchyme Mesenchyme that is part of a developing gonad [Automatically generated definition]. RBO_relaxed.owl GO:0060047 biolink:NamedThing heart contraction The multicellular organismal process in which the heart decreases in volume in a characteristic way to propel blood through the body. RBO_relaxed.owl UBERON:0002080 biolink:NamedThing heart right ventricle A cardiac ventricle that is in the right side of the heart. RBO_relaxed.owl PATO:0000587 biolink:NamedThing decreased size A size quality which is relatively low. RBO_relaxed.owl PR:000002981 biolink:NamedThing lymphocyte antigen 76 (mouse) A protein that is a translation product of the Ly76 gene in mouse. RBO_relaxed.owl Nb6d5e82a2d5b4c3e9ddfd262bf441d41 biolink:NamedThing RBO_relaxed.owl UBERON:0010136 biolink:NamedThing epithelial sheet An epithelial sheet is a flat surface consisting of closely packed epithelial cells. RBO_relaxed.owl PATO:0001410 biolink:NamedThing striated A shape quality inhering in a bearer by virtue of the bearer's being marked by narrow lines or grooves, usually parallel. RBO_relaxed.owl Nd61de1702eba484d864a72d91b442191 biolink:NamedThing RBO_relaxed.owl UBERON:0000926 biolink:NamedThing mesoderm The middle germ layer of the embryo, between the endoderm and ectoderm. RBO_relaxed.owl UBERON:0005066 biolink:NamedThing right ventricular trabecular myocardium Missing definition for term UBERON:0005066. Please replace it using linked reference. RBO_relaxed.owl UBERON:0000397 biolink:NamedThing colonic epithelium An epithelium that is part of a colon [Automatically generated definition]. RBO_relaxed.owl Ne1dd822829714fb6a9765084b1243a3b biolink:NamedThing RBO_relaxed.owl NCBITaxon:33213 biolink:NamedThing Bilateria RBO_relaxed.owl PR:000009054 biolink:NamedThing insulin gene translation product An insulin family protein that is a translation product of the human INS gene or a 1:1 ortholog thereof. RBO_relaxed.owl UBERON:0001021 biolink:NamedThing nerve An enclosed, cable-like bundle of axons in the peripheral nervous system originating in a nerve root in the central nervous system (or a condensed nervous structure) connecting with peripheral structures. RBO_relaxed.owl UBERON:0004291 biolink:NamedThing heart rudiment A cone-like structure that is formed when myocardial progenitor cells of the heart field fuse at the midline. The heart rudiment is the first structure of the heart tube. RBO_relaxed.owl Ndb9b012e095d4f7fbffaab164ad0bf10 biolink:NamedThing RBO_relaxed.owl NCBITaxon:9606 biolink:NamedThing Homo sapiens RBO_relaxed.owl N9e2a82385d60404e944834ed62cb41b9 biolink:NamedThing RBO_relaxed.owl NCBITaxon:33154 biolink:NamedThing Opisthokonta RBO_relaxed.owl UBERON:0008346 biolink:NamedThing duodenal epithelium An epithelium that is part of a duodenum. RBO_relaxed.owl GO:0060350 biolink:NamedThing endochondral bone morphogenesis The process in which bones are generated and organized as a result of the conversion of initial cartilaginous anlage into bone. RBO_relaxed.owl PATO:0002478 biolink:NamedThing transversely striated A shape quality inhering in a bearer by virtue of the bearer's being marked by narrow lines or grooves, usually parallel, that are oriented transversely relative to the long axis of the bearer. RBO_relaxed.owl NCBITaxon:2 biolink:NamedThing Bacteria RBO_relaxed.owl UBERON:0000922 biolink:NamedThing embryo Anatomical entity that comprises the organism in the early stages of growth and differentiation that are characterized by cleavage, the laying down of fundamental tissues, and the formation of primitive organs and organ systems. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant. RBO_relaxed.owl Nbd937ff2e4b6410eb67bad3e59bd42f7 biolink:NamedThing RBO_relaxed.owl N0cfa665fe12c4bb383526b74f1f9419b biolink:NamedThing RBO_relaxed.owl N872038d5bc6a44c9b42f61d6638fdd5b biolink:NamedThing RBO_relaxed.owl UBERON:8600004 biolink:NamedThing visceral muscle tissue A muscle tissue that is associated with soft internal organs (viscera). RBO_relaxed.owl N32658c18487c4e6688a097f7423241cb biolink:NamedThing RBO_relaxed.owl Naa925c93a2404e03b71b8a3bc18fe2d0 biolink:NamedThing RBO_relaxed.owl Na7d240d12d054813b86fb69fcb65dab2 biolink:NamedThing RBO_relaxed.owl UBERON:0003104 biolink:NamedThing mesenchyme Portion of tissue composed of mesenchymal cells (motile cells that develop from epthelia via an epithelial to mesenchymal transition) and surrounding extracellular material. Mesenchyme has different embryological origins in different metazoan taxa - in many invertebrates it derives in whole or part from ectoderm. In vertebrates it derives largely from mesoderm, and sometimes the terms are used interchangeably, e.g. lateral plate mesoderm/mesenchyme. RBO_relaxed.owl N52dcc382dd7545628c51ae7d50563671 biolink:NamedThing RBO_relaxed.owl N997fe8cc06e64c51897b5734c3ea3cc0 biolink:NamedThing RBO_relaxed.owl Nffdbd01bfdea4a2b939ac60c6a011b12 biolink:NamedThing RBO_relaxed.owl Nb57bd4dc4dff49ecb13eb78833c63c76 biolink:NamedThing RBO_relaxed.owl N6c91d45564c64bd3962e92606949a171 biolink:NamedThing RBO_relaxed.owl Nc764d27ed1a44624869375b4b607f768 biolink:NamedThing RBO_relaxed.owl N2adf487aee3241daa528c0b891d7cb57 biolink:NamedThing RBO_relaxed.owl UBERON:0002084 biolink:NamedThing heart left ventricle A cardiac ventricle that is in the left side of the heart. RBO_relaxed.owl GO:0098723 biolink:NamedThing skeletal muscle myofibril A myofibril of a skeletal muscle fiber. RBO_relaxed.owl N7094e65786a740f8bcdec9ecc5b8cc4a biolink:NamedThing RBO_relaxed.owl UBERON:0002029 biolink:NamedThing epithelium of gall bladder The simple columnar epithelial lining of the gall bladder. RBO_relaxed.owl Ne477dfb762aa4f8e8cb121d33fcfabd6 biolink:NamedThing RBO_relaxed.owl UBERON:0001045 biolink:NamedThing midgut Middle subdivision of a digestive tract[CJM]. In vertebrates: The middle part of the alimentary canal from the stomach, or entrance of the bile duct, to, or including, the large intestine[GO]. RBO_relaxed.owl Nd9382707281f44dfb553f320738f368a biolink:NamedThing RBO_relaxed.owl PR:000002112 biolink:NamedThing vascular endothelial growth factor receptor 2 A vascular endothelial growth factor receptor that is a translation product of the human KDR gene or a 1:1 ortholog thereof. RBO_relaxed.owl N1fb56fc1d0824248ba9ed43cf498605e biolink:NamedThing RBO_relaxed.owl UBERON:0000013 biolink:NamedThing sympathetic nervous system The sympathetic nervous system is one of the two divisions of the vertebrate autonomic nervous system (the other being the parasympathetic nervous system). The sympathetic preganglionic neurons have their cell bodies in the thoracic and lumbar regions of the spinal cord and connect to the paravertebral chain of sympathetic ganglia. Innervate heart and blood vessels, sweat glands, viscera and the adrenal medulla. Most sympathetic neurons, but not all, use noradrenaline as a post-ganglionic neurotransmitter [GO]. RBO_relaxed.owl UBERON:0000947 biolink:NamedThing aorta The main trunk of the systemic arterial system that carries blood from the heart to all the organs and other structures of the body, bringing oxygenated blood to all parts of the body in the systemic circulation. RBO_relaxed.owl UBERON:0001496 biolink:NamedThing ascending aorta The ascending aorta is the portion of the aorta in a two-pass circulatory system that lies between the heart and the arch of aorta[GO]. A portion of the aorta commencing at the upper part of the base of the left ventricle, on a level with the lower border of the third costal cartilage behind the left half of the sternum; it passes obliquely upward, forward, and to the right, in the direction of the heart's axis, as high as the upper border of the second right costal cartilage, describing a slight curve in its course, and being situated, about 6 cm behind the posterior surface of the sternum. The total length is about 5 cm in length [Wikipedia]. RBO_relaxed.owl NCBITaxon:89593 biolink:NamedThing Craniata RBO_relaxed.owl N19810e19befa4ae3ac6b3d8f6a475c05 biolink:NamedThing RBO_relaxed.owl PATO:0001405 biolink:NamedThing anucleate A nucleate quality inhering in a bearer by virtue of the bearer's having no nucleus. RBO_relaxed.owl UBERON:0001630 biolink:NamedThing muscle organ Organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work[GO]. RBO_relaxed.owl IAO:0000030 biolink:NamedThing information A generically dependent continuant that is about some thing.|An information entity is an entity that represents information about some other entity. For example, a measurement, a clustered data set. RBO_relaxed.owl UBERON:0002217 biolink:NamedThing synovial joint Joint in which the articulating bones or cartilages are connected by an articular capsule which encloses a synovial membrane and a synovial cavity. Examples: Temporomandibular joint, knee joint.[FMA]. RBO_relaxed.owl UBERON:0000025 biolink:NamedThing tube Any hollow cylindrical anatomical structure containing a lumen through which substances are transported. RBO_relaxed.owl PATO:0070047 biolink:NamedThing polychromatophilic An affinity inhering in an anatomical structure by virtue of the bearer exhibiting a molecular interaction for both basic and acid stains under specific pH conditions. RBO_relaxed.owl UBERON:0001133 biolink:NamedThing cardiac muscle tissue Muscle tissue composed of cardiac muscle cells, forming the muscles of the heart[ZFA,modified]. RBO_relaxed.owl UBERON:0003704 biolink:NamedThing intrahepatic bile duct Passages within the liver for the conveyance of bile. Includes right and left hepatic ducts even though these may join outside the liver to form the common hepatic duct. RBO_relaxed.owl PATO:0001154 biolink:NamedThing elongated A quality inhering in a bearer by virtue of the bearer's length being notably higher than its width. RBO_relaxed.owl N531dbb14bf584b11beeb8af3a4e6479d biolink:NamedThing RBO_relaxed.owl N5d71cf89c86f4afca3db92d43b5175d9 biolink:NamedThing RBO_relaxed.owl UBERON:0005388 biolink:NamedThing photoreceptor array An array of photoreceptors and any supporting cells found in an eye. RBO_relaxed.owl N0de26dc58637471a8ecb87e4b095473f biolink:NamedThing RBO_relaxed.owl OBO:RBO_00000116 biolink:NamedThing ionizing radiation Particle or electromagnetic radiation with sufficient energy to liberate one or more electrons from an atom. RBO_relaxed.owl UBERON:0003059 biolink:NamedThing presomitic mesoderm Unsegmented field of paraxial mesoderm present posterior to the most recently formed somite pair, from which somites will form. RBO_relaxed.owl Na4bfc622be8c44e98983d6c6da392a20 biolink:NamedThing RBO_relaxed.owl PATO:0001908 biolink:NamedThing multinucleate A nucleate quality inhering in a bearer by virtue of the bearer's having more than one nucleus. RBO_relaxed.owl UBERON:0001049 biolink:NamedThing neural tube In the developing vertebrate, the neural tube is the embryo's precursor to the central nervous system, which comprises the brain and spinal cord. The neural groove gradually deepens as the neural folds become elevated, and ultimately the folds meet and coalesce in the middle line and convert the groove into a closed tube, the neural tube or neural canal (which strictly speaking is the center of the neural tube), the ectodermal wall of which forms the rudiment of the nervous system. [WP,unvetted]. RBO_relaxed.owl UBERON:0001064 biolink:NamedThing ventral pancreatic duct A duct joining the pancreas to the common bile duct to supply pancreatic juices which aid in digestion provided by the exocrine pancreas. The pancreatic duct joins the common bile duct just prior to the ampulla of Vater, after which both ducts perforate the medial side of the second portion of the duodenum at the major duodenal papilla. RBO_relaxed.owl UBERON:0005742 biolink:NamedThing adventitia An outermost connective tissue covering of an organ, vessel, or other structure[WP]. RBO_relaxed.owl UBERON:0002079 biolink:NamedThing left cardiac atrium A cardiac atrium that is in the left side of the heart. It receives oxygenated blood from the pulmonary veins, In mammals this is pumped into the left ventricle, via the Mitral valve. RBO_relaxed.owl NCBITaxon:142796 biolink:NamedThing Eumycetozoa RBO_relaxed.owl NCBITaxon:50557 biolink:NamedThing Insecta RBO_relaxed.owl N02c1496460ce457990190f174e9cbef0 biolink:NamedThing RBO_relaxed.owl N3234447e4ba147e5a2c9d89fb1ec045d biolink:NamedThing RBO_relaxed.owl UBERON:0002354 biolink:NamedThing cardiac Purkinje fiber The cardiac Purkinje fiber is part of the cardiac conduction system that receives signals from the bundle of His and innervates the ventricular cardiac muscle. RBO_relaxed.owl UBERON:0001895 biolink:NamedThing metencephalon Rostral segment of the hindbrain that has as its parts the pons (where present) and the cerebellum[WP,modified]. RBO_relaxed.owl Na353b4c15c474e9e8ea64d3cac7af64a biolink:NamedThing RBO_relaxed.owl UBERON:0000162 biolink:NamedThing cloaca Common chamber into which the intestines and excretory system opens. Arises during development in all vertebrates, but in many it becomes subdivided, lost or incorporated into other structures. RBO_relaxed.owl PATO:0001402 biolink:NamedThing multipotent A cellular potency that is the capacity to form multiple differentiated cell types. RBO_relaxed.owl UBERON:0005062 biolink:NamedThing neural fold One of the two elevated edges of the neural groove[GO,MP]. RBO_relaxed.owl N17bfe3e268004397a137de23cf67c616 biolink:NamedThing RBO_relaxed.owl UBERON:0000068 biolink:NamedThing embryo stage A life cycle stage that starts with fertilization and ends with the fully formed embryo. RBO_relaxed.owl UBERON:0016405 biolink:NamedThing pulmonary capillary A capillary that is part of a lung. RBO_relaxed.owl N5239a89cd12946b496c36ca18028e829 biolink:NamedThing RBO_relaxed.owl UBERON:0000479 biolink:NamedThing tissue Multicellular anatomical structure that consists of many cells of one or a few types, arranged in an extracellular matrix such that their long-range organisation is at least partly a repetition of their short-range organisation. RBO_relaxed.owl N0ca42701fbfc49978a7b8c4283354edc biolink:NamedThing RBO_relaxed.owl N43541047816a42469b707d099105f57b biolink:NamedThing RBO_relaxed.owl UBERON:0001917 biolink:NamedThing endothelium of artery An endothelium that is part of an artery [Automatically generated definition]. RBO_relaxed.owl UBERON:0005317 biolink:NamedThing pulmonary artery endothelium An pulmonary artery endothelium is an epithelium that lines the pulmonary artery[GO]. RBO_relaxed.owl N3e4616d68c9e4fb4ba90e18af573d1a2 biolink:NamedThing RBO_relaxed.owl UBERON:0004126 biolink:NamedThing trabecular layer of ventricle A myocardium trabecular layer that is part of a cardiac ventricle. RBO_relaxed.owl PATO:0000309 biolink:NamedThing young An age which is relatively low. RBO_relaxed.owl N20dfc13f581f4802868bbc7432b47ba6 biolink:NamedThing RBO_relaxed.owl PATO:0001406 biolink:NamedThing binucleate A nucleate quality inhering in a bearer by virtue of the bearer's having two nuclei. RBO_relaxed.owl UBERON:0001639 biolink:NamedThing hepatic portal vein A portal vein that transports nutrients from the digestive tract to the liver[Kardong]. RBO_relaxed.owl UBERON:0000179 biolink:NamedThing haemolymphatic fluid Circulating fluid that is part of the hemolymphoid system. Blood, lymph, interstitial fluid or its analogs. RBO_relaxed.owl N2761a836b3e141f8b7e0c907ccab379c biolink:NamedThing RBO_relaxed.owl UBERON:0001238 biolink:NamedThing lamina propria of small intestine Lamina propria that is part_of the small intestine. RBO_relaxed.owl PATO:0002352 biolink:NamedThing herbaceous A quality inhering in a bearer by virtue of the bearer's upper parts die back to the rootstock at the end of the growing season. RBO_relaxed.owl UBERON:0001607 biolink:NamedThing sphincter pupillae A sphincter muscle that is part of the iris. RBO_relaxed.owl UBERON:0003077 biolink:NamedThing paraxial mesoderm The paraxial mesoderm is the mesoderm located bilaterally adjacent to the notochord and neural tube[GO]. RBO_relaxed.owl UBERON:0000371 biolink:NamedThing syncytiotrophoblast Extraembryonic cells of trophoblastic shell surrounding embryo, outside the cytotrophoblast layer, involved with implantation of the blastocyst by eroding extracellular matrix surrounding maternal endometrial cells at site of implantation, also contribute to villi. (dark staining, multinucleated). RBO_relaxed.owl N66549eb97f03462a92a83ecc9ea81c33 biolink:NamedThing RBO_relaxed.owl PATO:0000586 biolink:NamedThing increased size A size quality which is relatively high. RBO_relaxed.owl UBERON:0004148 biolink:NamedThing cardiac vein Vein of heart that drains the myocardium. RBO_relaxed.owl Nd33b7a645c1f4aaaa08f23f1056d4a2d biolink:NamedThing RBO_relaxed.owl N72dce6a816fb4522b3e8e8860965b814 biolink:NamedThing RBO_relaxed.owl UBERON:0002351 biolink:NamedThing sinoatrial node The part of the cardiac conduction system that controls the timing of heart muscle contraction. It relays electrical signals to the AV node[GO]. Subdivision of conducting system of heart at the junction of the right atrium and the superior vena cava, around the sinoatrial nodal branch of right coronary artery and is continuous with the internodal tract[FMA]. RBO_relaxed.owl N94c8db3ffb0945c6afb939581c28fec5 biolink:NamedThing RBO_relaxed.owl UBERON:0002298 biolink:NamedThing brainstem Stalk-like part of the brain that includes amongst its parts the medulla oblongata of the hindbrain and the tegmentum of the midbrain[ZFA,MP,generalized]. RBO_relaxed.owl UBERON:0008998 biolink:NamedThing vasculature of brain System pertaining to blood vessels in the brain. RBO_relaxed.owl UBERON:0001780 biolink:NamedThing spinal nerve The any of the paired peripheral nerves formed by the union of the dorsal and ventral spinal roots from each spinal cord segment[MP,modified]. RBO_relaxed.owl N7eb82c7cb17645f0bee7eb904a2d6077 biolink:NamedThing RBO_relaxed.owl N421105642ccf4e1da7b0b51e01870058 biolink:NamedThing RBO_relaxed.owl Nd676f74fac374cc2aead3c0f0b909aa5 biolink:NamedThing RBO_relaxed.owl UBERON:0004088 biolink:NamedThing orbital region The subdivision of the face that includes the eye (eyeball plus adnexa such as eyelids) and the orbit of the skull and associated parts of the face such as the eyebrows, if present. RBO_relaxed.owl UBERON:0001637 biolink:NamedThing artery An epithelial tube or tree of tibes that transports blood away from the heart[modified from AEO definition]. RBO_relaxed.owl UBERON:0004176 biolink:NamedThing external genitalia The external genitalia are the outer sex organs, such as the penis or vulva in mammals. RBO_relaxed.owl PATO:0001546 biolink:NamedThing quality of a solid A physical quality inhering in a bearer by virtue of the bearer's exhibiting the physical characteristics of an entity characterized by particles arranged such that their shape and volume are relatively stable. RBO_relaxed.owl Ncbf61323cf8b4cecad55802850f6a7a0 biolink:NamedThing RBO_relaxed.owl NCBITaxon:147537 biolink:NamedThing Saccharomycotina RBO_relaxed.owl UBERON:0006799 biolink:NamedThing glandular epithelium An epithelium that is composed primarily of secretory cells. RBO_relaxed.owl Nae00e2747a4543f3a16201b391baad4f biolink:NamedThing RBO_relaxed.owl UBERON:0001416 biolink:NamedThing skin of abdomen A zone of skin that is part of an abdomen [Automatically generated definition]. RBO_relaxed.owl N860cdabf66a44d1399934983440e7eb0 biolink:NamedThing RBO_relaxed.owl UBERON:0009015 biolink:NamedThing upper back skin A zone of skin that is part of a dorsal thoracic segment of trunk. RBO_relaxed.owl UBERON:0004141 biolink:NamedThing heart tube An epithelial tube that will give rise to the mature heart. RBO_relaxed.owl UBERON:0004160 biolink:NamedThing proepicardium An embryonic group of progenitor cells that forms from an outpouching of the septum transversum near the venous pole of the heart and gives rise to the epicardium. RBO_relaxed.owl UBERON:0006841 biolink:NamedThing central vein of liver Vein that is central to a lobule in the liver. RBO_relaxed.owl UBERON:0002257 biolink:NamedThing ventral horn of spinal cord The ventral grey column of the spinal cord[MP]. The neurons of the ventral region of the mature spinal cord participate in motor output[GO]. RBO_relaxed.owl UBERON:0002062 biolink:NamedThing endocardial cushion The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves[GO]. Swellings of tissue present between the endocardial and myocardial cell layers that will give rise to the interstitial cells of the cardiac valves[ZFA]. RBO_relaxed.owl N25fbf16228854b80a7feede5998dad07 biolink:NamedThing RBO_relaxed.owl Nc1dd4787f08d4724bfcf6b658b8aba66 biolink:NamedThing RBO_relaxed.owl PATO:0001401 biolink:NamedThing oligopotent A cellular potency that is the capacity to form multiple differentiated cell types of a specific lineage and lack self renewing capacity. RBO_relaxed.owl N4006fe6f321f489a8d80e0da69d361b6 biolink:NamedThing RBO_relaxed.owl N8a3dac8ae7f9423296575a00d1b80a3d biolink:NamedThing RBO_relaxed.owl Ndb0489915d73492ab8c570edfcb13009 biolink:NamedThing RBO_relaxed.owl Na239056dbcc147c09dfaa9f17ba34808 biolink:NamedThing RBO_relaxed.owl UBERON:0002412 biolink:NamedThing vertebra The ossified form of a vertebral element, a skeletal element that forms around the notochord and is part of the vertebral column. RBO_relaxed.owl UBERON:0004178 biolink:NamedThing aorta smooth muscle tissue The nonstriated, involuntary muscle tissue located in the wall of the aorta. RBO_relaxed.owl UBERON:0003073 biolink:NamedThing lens placode A thickened portion of ectoderm which serves as the precursor to the lens. SOX2 and Pou2f1 are involved in its development[WP]. RBO_relaxed.owl N3a066f5631df46fd911ca6bd2e12ffc7 biolink:NamedThing RBO_relaxed.owl Ndab2ab14a6ba404da09ce78ff4c27558 biolink:NamedThing RBO_relaxed.owl UBERON:0010523 biolink:NamedThing microcirculatory vessel A vessel of the microcirculature, lying between the arterioles and venules; includes capillaries (blood and lymphatic), metarterioles and arteriovenous anastomoses. RBO_relaxed.owl N4b8f1a3af3074ca98a79c0616c7e1c07 biolink:NamedThing RBO_relaxed.owl N690fb8ef93f4457fa31f6d732b3e56eb biolink:NamedThing RBO_relaxed.owl Neb394646743a44718ec7bd2eed92ca6c biolink:NamedThing RBO_relaxed.owl Nc1631258de5b4b94bf391203b82fd4fe biolink:NamedThing RBO_relaxed.owl N1bef8f6211fa414f8952f607b7824dfb biolink:NamedThing RBO_relaxed.owl PATO:0001657 biolink:NamedThing increased osmolarity A osmolarity which is relatively high. RBO_relaxed.owl N69117bc5266341f4918a81bc6769faae biolink:NamedThing RBO_relaxed.owl UBERON:0004664 biolink:NamedThing aorta tunica adventitia The outermost layer of the aorta wall, containing connective tissue and collagen and elastic fibers. RBO_relaxed.owl NCBITaxon:32443 biolink:NamedThing Teleostei RBO_relaxed.owl UBERON:0002012 biolink:NamedThing pulmonary artery An artery that carries deoxygenated blood from heart to the lungs. They are the only arteries (other than umbilical arteries in the fetus) that carry deoxygenated blood.. RBO_relaxed.owl N84b714f117674bf5aba320a1ddd89d6c biolink:NamedThing RBO_relaxed.owl UBERON:0002085 biolink:NamedThing interatrial septum A cardiac septum that divides the left and right atria of the heart. RBO_relaxed.owl UBERON:0005396 biolink:NamedThing carotid artery segment One of: the common carotid artery, or its branches, the external and internal carotid arteries. RBO_relaxed.owl UBERON:0002513 biolink:NamedThing endochondral bone Replacement bone that forms within cartilage. RBO_relaxed.owl UBERON:0001366 biolink:NamedThing parietal peritoneum The outer layer of peritoneum that is attached to the abdominal and pelvic walls. RBO_relaxed.owl PATO:0002094 biolink:NamedThing basophilic An affinity inhering in an anatomical structure by virtue of the bearer exhibiting a molecular interaction for basic dyes under specific pH conditions. RBO_relaxed.owl Na261579c58bf4afdb5e29b9cfde31c03 biolink:NamedThing RBO_relaxed.owl N3a32bd3c5c934d799440b91100e6620d biolink:NamedThing RBO_relaxed.owl Nc54a4c27d61b4e70adcb0373b9ca13cd biolink:NamedThing RBO_relaxed.owl UBERON:0004997 biolink:NamedThing mucosa of pyloric antrum A mucosa that is part of a pyloric antrum [Automatically generated definition]. RBO_relaxed.owl UBERON:0011189 biolink:NamedThing lamina propria of large intestine A lamina propria that is part of a large intestine. RBO_relaxed.owl N90b0cc4545bf4e2f8397c87599df36e4 biolink:NamedThing RBO_relaxed.owl UBERON:0004638 biolink:NamedThing blood vessel endothelium An endothelium that lines the blood vasculature. Other endothelia may line lymph vessels, the heart. RBO_relaxed.owl UBERON:0004175 biolink:NamedThing internal genitalia The internal genitalia are the internal sex organs such as the uterine tube, the uterus and the vagina in female mammals, and the testis, seminal vesicle, ejaculatory duct and prostate in male mammals. RBO_relaxed.owl PATO:0015022 biolink:NamedThing increased combustibility An increase in combustibility. RBO_relaxed.owl N9a50964086104cd0bb099c29aff5b9fa biolink:NamedThing RBO_relaxed.owl N6df3eab3180046feaf091f779b7b965b biolink:NamedThing RBO_relaxed.owl N50ee8235d8da4711a8acd23b8e18c415 biolink:NamedThing RBO_relaxed.owl Nd1a0482d18594602b86261b300508fff biolink:NamedThing RBO_relaxed.owl Na80c470863934bd1a9e7ed8e3c56b5dc biolink:NamedThing RBO_relaxed.owl N36a54ac88d314bc3aa2fbd960e12d27d biolink:NamedThing RBO_relaxed.owl N5bffedd94f684316879b8ceae6658fc3 biolink:NamedThing RBO_relaxed.owl Nca8d195f528049f5986d87ea706eaee8 biolink:NamedThing RBO_relaxed.owl UBERON:0001638 biolink:NamedThing vein Any of the tubular branching vessels that carry blood from the capillaries toward the heart. RBO_relaxed.owl UBERON:0001008 biolink:NamedThing renal system The renal system in an anatomical system that maintains fluid balance and contributes to electrolyte balance, acid/base balance, and disposal of nitrogenous waste products. RBO_relaxed.owl N9b432b268c1e4dae80386862d0a76f96 biolink:NamedThing RBO_relaxed.owl UBERON:0000026 biolink:NamedThing appendage Major subdivision of an organism that protrudes from the body[DOS, CARO]. RBO_relaxed.owl PATO:0001199 biolink:NamedThing linear A shape quality inhering in a bearer by virtue of the bearer's being narrow, with the two opposite margins parallel. RBO_relaxed.owl UBERON:0001558 biolink:NamedThing lower respiratory tract The segment of the respiratory tract that starts proximally with the trachea and includes all distal structures including the lungs[WP,modified]. RBO_relaxed.owl PATO:0001332 biolink:NamedThing amorphous A morphology quality inhering in a bearer by virtue of the bearer's lack of distinct morphology. RBO_relaxed.owl UBERON:0007376 biolink:NamedThing outer epithelium The epidermis is the entire outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species[GO]. RBO_relaxed.owl N1aa3627780524cf28bfb97c83351e036 biolink:NamedThing RBO_relaxed.owl UBERON:0005805 biolink:NamedThing dorsal aorta The dorsal aorta is a blood vessel in a single-pass circulatory system that carries oxygenated blood from the gills to the rest of the body. In a single-pass circulatory system blood passes once through the heart to supply the body once. RBO_relaxed.owl UBERON:0000102 biolink:NamedThing lung vasculature The lung vasculature is composed of the tubule structures that carry blood or lymph in the lungs[GO]. RBO_relaxed.owl UBERON:0001281 biolink:NamedThing hepatic sinusoid Wide thin-walled blood vessels in the liver. In mammals they have neither veinous or arterial markers. RBO_relaxed.owl UBERON:0000478 biolink:NamedThing extraembryonic structure A multicellular anatomical structure that is associated with an embryo and derived from the zygote from which it develops, but which does not contribute to the embryo proper or to structures that are part of the same organism after embryogenesis. RBO_relaxed.owl N70661059f0e04f66a593e0238ec5da4b biolink:NamedThing RBO_relaxed.owl Ndf10ed0184cd487baeb230cb122e78fb biolink:NamedThing RBO_relaxed.owl UBERON:0009842 biolink:NamedThing glandular acinus The many-lobed berry cluster of cells that is the terminous of a gland where the secretion is produced is acinar in form. RBO_relaxed.owl Ncd867e627dad43798f6eec14b5c35dda biolink:NamedThing RBO_relaxed.owl N9fd11e59ecd5494099b55b8e39b02bc5 biolink:NamedThing RBO_relaxed.owl PATO:0002143 biolink:NamedThing sloped downward RBO_relaxed.owl UBERON:0000949 biolink:NamedThing endocrine system Anatomical system that consists of the glands and parts of glands that produce endocrine secretions and help to integrate and control bodily metabolic activity. RBO_relaxed.owl UBERON:0004823 biolink:NamedThing intrahepatic bile duct epithelium An epithelium that is part of a intrahepatic bile duct [Automatically generated definition]. RBO_relaxed.owl UBERON:0009850 biolink:NamedThing nematode larva A multicellular organism that existence_starts_and_ends_during a nematode larval stage. RBO_relaxed.owl Naad67c46bbec464f9ca2e2c03fb8d304 biolink:NamedThing RBO_relaxed.owl PATO:0001407 biolink:NamedThing mononucleate A nucleate quality inhering in a bearer by virtue of the bearer's having one nucleus. RBO_relaxed.owl UBERON:0001766 biolink:NamedThing anterior chamber of eyeball The space in the eye, filled with aqueous humor, and bounded anteriorly by the cornea and a small portion of the sclera and posteriorly by a small portion of the ciliary body, the iris, and part of the crystalline lens. RBO_relaxed.owl N8d828d5a42344f9e9837405cf6912182 biolink:NamedThing RBO_relaxed.owl PATO:0001731 biolink:NamedThing deciduous (plant) A quality inhering in a plant by virtue of the bearer's disposition to shed foliage. RBO_relaxed.owl UBERON:0001915 biolink:NamedThing endothelium of capillary An endothelium that is part of a capillary [Automatically generated definition]. RBO_relaxed.owl N64c4e8ea6b944b74a8a88fe7a8111bbe biolink:NamedThing RBO_relaxed.owl UBERON:0005064 biolink:NamedThing left ventricular trabecular myocardium Missing definition for term UBERON:0005064. Please replace it using linked reference. RBO_relaxed.owl N9e54b8f2319d48d78660e64edfe1d265 biolink:NamedThing RBO_relaxed.owl Nd86997d7e530450099d833b2c0d84648 biolink:NamedThing RBO_relaxed.owl N3b2b6bbef6e34cc5bce836bc972fa350 biolink:NamedThing RBO_relaxed.owl UBERON:0001902 biolink:NamedThing epithelium of small intestine An epithelium that is part of a small intestine [Automatically generated definition]. RBO_relaxed.owl N61ff2129fb204757a76e5e70f2538fb2 biolink:NamedThing RBO_relaxed.owl N9e8a287f99964fdb9b40e1004cf70eb7 biolink:NamedThing RBO_relaxed.owl PATO:0002039 biolink:NamedThing biconcave A concave quality inhering in a bearer by virtue of the bearer's curving inward on both sides or surfaces. RBO_relaxed.owl UBERON:0000115 biolink:NamedThing lung epithelium The epithelial layer of the lung. RBO_relaxed.owl N0891222d736f46f4a844c37ee6c943e8 biolink:NamedThing RBO_relaxed.owl Nd31eef07ea5e4f3bb393670ff53ab61a biolink:NamedThing RBO_relaxed.owl N4010863a04714df687fc0c7a405dda87 biolink:NamedThing RBO_relaxed.owl UBERON:0001178 biolink:NamedThing visceral peritoneum The inner layer of peritoneum that is wrapped around organs located inside the intraperitoneal space. RBO_relaxed.owl PATO:0001545 biolink:NamedThing inflexible A physical quality inhering in a bearer by virtue of the bearer's inability of being turned, bowed, or twisted without breaking. RBO_relaxed.owl UBERON:0004161 biolink:NamedThing septum transversum A thick plate of mesodermal tissue that occupies the space between the thoracic cavity and yolk stalk in the early embryo, forming a transverse partition partially separating the coelomic cavity into thoracic and abdominal portions. It gives rise to the central tendon of the diaphragm[VHOG]. RBO_relaxed.owl UBERON:0001068 biolink:NamedThing skin of back A zone of skin that is part of a back [Automatically generated definition]. RBO_relaxed.owl N3b52a5dce1da41d5a67c8851f2e5ba0d biolink:NamedThing RBO_relaxed.owl UBERON:0004667 biolink:NamedThing interventricular septum muscular part The muscular portion of the wall between the two lower chambers of the heart. RBO_relaxed.owl N643e41046b014487b3e06a1a987ca169 biolink:NamedThing RBO_relaxed.owl UBERON:0000125 biolink:NamedThing neural nucleus A spatially aggregated collection of nerve cell bodies in the CNS, consisting of one or more subpopulations that share cell type, chemical phenotype, and connections, and including nearby cells that share the same cell type, chemical phenotype, and connections. (CUMBO). RBO_relaxed.owl PATO:0000308 biolink:NamedThing old An age which is relatively high. RBO_relaxed.owl PATO:0001689 biolink:NamedThing decreased elevation An elevation which is relatively low. RBO_relaxed.owl PO:0025034 biolink:NamedThing leaf A phyllome (PO:0006001) that is not associated with a reproductive structure. RBO_relaxed.owl UBERON:0001529 biolink:NamedThing brachiocephalic artery The short first aortic arch branch and divides into the right subclavian artery and the right common carotid artery. RBO_relaxed.owl PATO:0001481 biolink:NamedThing sloped A shape quality inhering in a bearer by virtue of the bearer's having an oblique or slanted direction. RBO_relaxed.owl UBERON:0001986 biolink:NamedThing endothelium A layer of epithelium that lines the heart, blood vessels (endothelium, vascular), lymph vessels (endothelium, lymphatic), and the serous cavities of the body[MESH]. Simple squamous epithelium which lines blood and lymphatic vessels and the heart[FMA]. RBO_relaxed.owl UBERON:0001052 biolink:NamedThing rectum The terminal portion of the intestinal tube, terminating with the anus. RBO_relaxed.owl UBERON:0003909 biolink:NamedThing sinusoid Small blood vessel similar to a capillary but with a fenestrated endothelium. Sinusoids are found in the liver, lymphoid tissue, endocrine organs, and hematopoietic organs such as the bone marrow and the spleen. Sinusoids found within terminal villi of the placenta are not comparable to these; they possess a continuous endothelium and complete basal lamina[WP]. RBO_relaxed.owl N7f5cc9ce3252444a9250b14cb567ee21 biolink:NamedThing RBO_relaxed.owl Nc80f2e2b144042d4bd3cb441da0488f6 biolink:NamedThing RBO_relaxed.owl N9206d78a08a9468a8d8e7724a917a331 biolink:NamedThing RBO_relaxed.owl UBERON:0013695 biolink:NamedThing colon endothelium Vascular endothelium found in colon blood vessels. RBO_relaxed.owl UBERON:0003381 biolink:NamedThing cardiac muscle of right ventricle A portion of cardiac muscle tissue that is part of a right ventricle [Automatically generated definition]. RBO_relaxed.owl UBERON:0007177 biolink:NamedThing lamina propria of mucosa of colon A lamina propria that is part of a colonic mucosa. RBO_relaxed.owl PATO:0001688 biolink:NamedThing increased elevation An elevation which is relatively high. RBO_relaxed.owl N40c5f86cc9374e588c3ca3fa509a2578 biolink:NamedThing RBO_relaxed.owl N15cb359f7d4f4484a0a0995ff9bafce6 biolink:NamedThing RBO_relaxed.owl N0ef22ce4fea74c80bb56cdf394765939 biolink:NamedThing RBO_relaxed.owl N2582a89bf8df401a93198dfeff8e92d2 biolink:NamedThing RBO_relaxed.owl UBERON:0006966 biolink:NamedThing coronary capillary A capillary that is part of the coronary system. RBO_relaxed.owl NCBITaxon:33090 biolink:NamedThing Viridiplantae RBO_relaxed.owl N4b201445a937433aa4d5f75ed036d0e3 biolink:NamedThing RBO_relaxed.owl UBERON:0001004 biolink:NamedThing respiratory system Functional system which consists of structures involved in respiration. RBO_relaxed.owl UBERON:0001003 biolink:NamedThing skin epidermis The outer epithelial layer of the skin that is superficial to the dermis. RBO_relaxed.owl UBERON:0003103 biolink:NamedThing compound organ Anatomical structure that has as its parts two or more multi-tissue structures of at least two different types and which through specific morphogenetic processes forms a single distinct structural unit demarcated by bona fide boundaries from other distinct anatomical structures of different types. RBO_relaxed.owl UBERON:0001152 biolink:NamedThing cystic duct The tubular structure that conducts gall bladder contents from the gall bladder to the common bile duct. RBO_relaxed.owl UBERON:0004590 biolink:NamedThing sphincter muscle A structure, usually a circular muscle, that normally maintains constriction of a natural body passage or orifice and which relaxes as required by normal physiological functioning. RBO_relaxed.owl N2a5943330ca8405899122240afe4b54d biolink:NamedThing RBO_relaxed.owl PATO:0002418 biolink:NamedThing acidophilic An affinity inhering in an anatomical structure by virtue of the bearer exhibiting a molecular interaction for acidic dyes under specific pH conditions. RBO_relaxed.owl Nef9ca08566cf4b1aa6f8dee6ef33588f biolink:NamedThing RBO_relaxed.owl Nf27682f69c2d41d982b9e6ee8281ef09 biolink:NamedThing RBO_relaxed.owl Nf81cf01700554343a806b4a3e207cf1f biolink:NamedThing RBO_relaxed.owl PATO:0000963 biolink:NamedThing opaque A optical quality inhering in a bearer by virtue of the bearer's not being clear; not transmitting or reflecting light or radiant energy. RBO_relaxed.owl UBERON:0002424 biolink:NamedThing oral epithelium An epithelium that is part of the mouth and lines the oral cavity, typically stratified squamous, and may be para-, ortho- or non- keratinized. Primary barrier between oral environment and deeper tissues. RBO_relaxed.owl N059a5925a4a145c39e1914493fc768d7 biolink:NamedThing RBO_relaxed.owl N030ae09e4dd14c67b061c117a826d719 biolink:NamedThing RBO_relaxed.owl N3016143161e742f18541b48461832cb8 biolink:NamedThing RBO_relaxed.owl N58d275c04567415e9af0e32d8ac54293 biolink:NamedThing RBO_relaxed.owl Nfaf6fbceeff547d3a28ae8ce96309e28 biolink:NamedThing RBO_relaxed.owl Ndd6a4c137dc94e419737d93e3787fb8d biolink:NamedThing RBO_relaxed.owl N466166af326b4308ba0da608a9814345 biolink:NamedThing RBO_relaxed.owl N358965b015ef4c7d93bf01b1e047b273 biolink:NamedThing RBO_relaxed.owl Nef09bd96c5424eaab1332a2255b2d072 biolink:NamedThing RBO_relaxed.owl Nc29038b82c0e47989610e191fcac2eae biolink:NamedThing RBO_relaxed.owl N5842260388ed4e4e9820f337f8e34493 biolink:NamedThing RBO_relaxed.owl N6929f3001e8c4826915ccec83fd21f47 biolink:NamedThing RBO_relaxed.owl UBERON:0002521 biolink:NamedThing elastic tissue Connective tissue composed of elastic fibers. RBO_relaxed.owl UBERON:0004684 biolink:NamedThing raphe nuclei The raphe nuclei are thin plates of cells in and immediately adjacent to the sagittal plane. RBO_relaxed.owl UBERON:0004802 biolink:NamedThing respiratory tract epithelium The pseudostratified ciliated epithelium that lines much of the conducting portion of the airway, including part of the nasal cavity and larynx, the trachea, and bronchi. RBO_relaxed.owl N5460f25e632f40a69ed0ef6a4431093c biolink:NamedThing RBO_relaxed.owl N88ed1cba08f547fd8fcf1915f0d723a3 biolink:NamedThing RBO_relaxed.owl UBERON:0001980 biolink:NamedThing arteriole The smallest division of the artery located between the muscular arteries and the capillaries[GO]. RBO_relaxed.owl N183b951fbc2343be9f648efbf477c8ce biolink:NamedThing RBO_relaxed.owl UBERON:0007135 biolink:NamedThing neural keel An intermediate stage (between the neural plate and neural rod) during the early segmentation period in the morphogenesis of the central nervous system primordium; the keel is roughly triangular shaped in cross section. RBO_relaxed.owl N0df84910cfef45ab859f6de7f4df7f1e biolink:NamedThing RBO_relaxed.owl PATO:0001547 biolink:NamedThing quality of a gas A physical quality inhering in a bearer by virtue of the bearer's exhibiting the physical characteristics of an entity consisting of particles that have neither a defined volume nor defined shape. RBO_relaxed.owl N01a44cb70ec445118131bb55b24a6fa4 biolink:NamedThing RBO_relaxed.owl Nd88f9a007e5b49deb01774487f3cc56c biolink:NamedThing RBO_relaxed.owl Nc525c1ff9a4b474ba1331690abdb83ea biolink:NamedThing RBO_relaxed.owl Nb76283945e594aa5a65d80ebcca00dec biolink:NamedThing RBO_relaxed.owl Nb9a1de3838bc4f578003163fca456015 biolink:NamedThing RBO_relaxed.owl UBERON:0001533 biolink:NamedThing subclavian artery One of two laterally paired arteries that supplies the pectoral appendages, usually branching from the dorsal aorta. RBO_relaxed.owl N62bd54a1e4d348649358cfc68f11c301 biolink:NamedThing RBO_relaxed.owl Nceaa39b713d141229eaa8a551119cecb biolink:NamedThing RBO_relaxed.owl PATO:0001422 biolink:NamedThing dead A viability quality inhering in a bearer by virtue of the cessation of the bearer's life. RBO_relaxed.owl N6c084974fc344a4aa6eedff19c013e7e biolink:NamedThing RBO_relaxed.owl N60719a4315f24737b427e7d382d8a158 biolink:NamedThing RBO_relaxed.owl Ne4fc01dd46f646d69c27bbf18c30d90d biolink:NamedThing RBO_relaxed.owl N43a8c32faf9e4c77b9409d234e887855 biolink:NamedThing RBO_relaxed.owl N31a3db5a2c684f7a93399c77e168d104 biolink:NamedThing RBO_relaxed.owl Nba141c872df44f24b7c70aee10dd9e1a biolink:NamedThing RBO_relaxed.owl UBERON:0000916 biolink:NamedThing abdomen The subdivision of the vertebrate body between the thorax and pelvis. The ventral part of the abdomen contains the abdominal cavity and visceral organs. The dorsal part includes the abdominal section of the vertebral column. RBO_relaxed.owl N62cc966301634ddabf43515b0c5d775a biolink:NamedThing RBO_relaxed.owl N6340e8867558479f98a4caf65f254be0 biolink:NamedThing RBO_relaxed.owl N56990177498c4f2893206ae7b764106d biolink:NamedThing RBO_relaxed.owl PATO:0001377 biolink:NamedThing polyploid A ploidy quality inhering in a bearer by virtue of the bearer's containing more than two homologous sets of chromosomes. RBO_relaxed.owl N5e56c966536f40eeb017fb3baefc1cbd biolink:NamedThing RBO_relaxed.owl Nb2357353aeed41d1bdf4f8a3c17aabf8 biolink:NamedThing RBO_relaxed.owl UBERON:0000325 biolink:NamedThing gastric gland The branched tubular glands found in the mucosa of the fundus and body of the stomach which contain parietal cells that secrete hydrochloric acid and zymogenic cells that produce pepsin. RBO_relaxed.owl PATO:0001393 biolink:NamedThing euploid A ploidy quality inhering in a bearer by virtue of the bearer's containing an integral multiple of the monoploid number, possibly excluding the sex-determining chromosomes. RBO_relaxed.owl UBERON:0005068 biolink:NamedThing neural rod A solid rod of neurectoderm derived from the neural keel. The neural rod is roughly circular in cross section. Neural rod formation occurs during primary neurulation in teleosts[GO]. An intermediate stage in the development of the central nervous system present during the segmentation period; the neural rod is roughly cylindrical in shape, forms from the neural keel, and is not yet hollowed out into the neural tube[ZFIN]. RBO_relaxed.owl UBERON:0000923 biolink:NamedThing germ layer A layer of cells produced during the process of gastrulation during the early development of the animal embryo, which is distinct from other such layers of cells, as an early step of cell differentiation. The three types of germ layers are the endoderm, ectoderm, and mesoderm. RBO_relaxed.owl GO:0060351 biolink:NamedThing cartilage development involved in endochondral bone morphogenesis The process whose specific outcome is the progression of the cartilage that will provide a scaffold for mineralization of endochondral bones. RBO_relaxed.owl N46f71517717d4a52ac159cfd1a6728cb biolink:NamedThing RBO_relaxed.owl PATO:0002254 biolink:NamedThing flattened A quality inhering in a bearer by virtue of the bearer's surface becoming more extended in a plane. RBO_relaxed.owl UBERON:0002358 biolink:NamedThing peritoneum A serous membrane that lines the peritoneal cavity[VHOG,modified]. RBO_relaxed.owl PATO:0002253 biolink:NamedThing platelike A quality inhering in a bearer by virtue of the bearer's being roundish, flattish shape, possibly with a slightly angled edge. RBO_relaxed.owl N3d7c377a28f941be96d810356f3cbc07 biolink:NamedThing RBO_relaxed.owl N8269cbb566ec4d499e72b36dcc6e747b biolink:NamedThing RBO_relaxed.owl Nb5f861e71a12418ea9e9346b855713f5 biolink:NamedThing RBO_relaxed.owl Nb93e74d1269c473f986f2722b131fce3 biolink:NamedThing RBO_relaxed.owl GO:0150063 biolink:NamedThing visual system development The process whose specific outcome is the progression of the visual system over time, from its formation to the mature structure, including the eye, parts of the central nervous system (CNS) involved in processing of visual inputs, and connecting nerve pathways. RBO_relaxed.owl UBERON:0001199 biolink:NamedThing mucosa of stomach The mucosal layer that lines the stomach. RBO_relaxed.owl N3d6c6b8e05a44c85a1c8875dd7ef3112 biolink:NamedThing RBO_relaxed.owl GO:0051905 biolink:NamedThing establishment of pigment granule localization The directed movement of a pigment granule to a specific location. RBO_relaxed.owl GO:1990182 biolink:NamedThing exosomal secretion The process whereby a membrane-bounded vesicle is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. RBO_relaxed.owl GO:0060581 biolink:NamedThing cell fate commitment involved in pattern specification The commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells within a field of cells that will exhibit a certain pattern of differentiation. Positional information is established through protein signals that emanate from a localized source within a developmental field resulting in specification of a cell type. Those signals are then interpreted in a cell-autonomous manner resulting in the determination of the cell type. RBO_relaxed.owl GO:0060795 biolink:NamedThing cell fate commitment involved in formation of primary germ layer The commitment of cells to specific cell fates of the endoderm, ectoderm, or mesoderm as a part of gastrulation. RBO_relaxed.owl GO:0061971 biolink:NamedThing replacement bone morphogenesis The process in which bones are generated and organized as a result of the conversion of another structural tissue into bone. RBO_relaxed.owl GO:0061972 biolink:NamedThing dermal bone morphogenesis The process in which bone which forms superficially in the organism are generated and organized. RBO_relaxed.owl GO:0061973 biolink:NamedThing membrane bone morphogenesis The process in which bone which forms deep in the organism are generated and organized. RBO_relaxed.owl GO:0060496 biolink:NamedThing mesenchymal-epithelial cell signaling involved in lung development Any process that mediates the transfer of information from a mesenchymal cell to an epithelial cell and contributes to the development of the lung. RBO_relaxed.owl GO:0061111 biolink:NamedThing epithelial-mesenchymal cell signaling involved in lung development Any process that results in the transfer of information from an epithelial cell to a mesenchymal cell and contributes to the progression of the lung over time from its initial formation to the mature organ. RBO_relaxed.owl GO:0060916 biolink:NamedThing mesenchymal cell proliferation involved in lung development The multiplication or reproduction of cells, resulting in the expansion of a mesenchymal cell population that contributes to the progression of the lung over time. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets. RBO_relaxed.owl GO:0060978 biolink:NamedThing angiogenesis involved in coronary vascular morphogenesis Blood vessel formation in the heart when new vessels emerge from the proliferation of pre-existing blood vessels. RBO_relaxed.owl GO:0061308 biolink:NamedThing cardiac neural crest cell development involved in heart development The process aimed at the progression of a cardiac neural crest cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell that contributes to the development of the heart. RBO_relaxed.owl GO:0061309 biolink:NamedThing cardiac neural crest cell development involved in outflow tract morphogenesis The process aimed at the progression of a cardiac neural crest cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell that contributes to the shaping of the outflow tract. RBO_relaxed.owl GO:0061385 biolink:NamedThing fibroblast proliferation involved in heart morphogenesis The multiplication or reproduction of fibroblasts, resulting in the expansion of a fibroblast population that contributes to the shaping of the heart. RBO_relaxed.owl GO:1990234 biolink:NamedThing transferase complex A protein complex capable of catalyzing the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). RBO_relaxed.owl GO:0070062 biolink:NamedThing extracellular exosome A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. RBO_relaxed.owl GO:0071480 biolink:NamedThing cellular response to gamma radiation Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gamma radiation stimulus. Gamma radiation is a form of electromagnetic radiation (EMR) or light emission of a specific frequency produced from sub-atomic particle interaction, such as electron-positron annihilation and radioactive decay. Gamma rays are generally characterized as EMR having the highest frequency and energy, and also the shortest wavelength, within the electromagnetic radiation spectrum. RBO_relaxed.owl GO:0071481 biolink:NamedThing cellular response to X-ray Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of X-ray radiation. An X-ray is a form of electromagnetic radiation with a wavelength in the range of 10 nanometers to 100 picometers (corresponding to frequencies in the range 30 PHz to 3 EHz). RBO_relaxed.owl GO:0086018 biolink:NamedThing SA node cell to atrial cardiac muscle cell signaling Any process that mediates the transfer of information from an SA node cardiomyocyte to an atrial cardiomyocyte. RBO_relaxed.owl GO:0086027 biolink:NamedThing AV node cell to bundle of His cell signaling Any process that mediates the transfer of information from an AV node cardiac muscle cell to a bundle of His cardiomyocyte. RBO_relaxed.owl GO:0086070 biolink:NamedThing SA node cell to atrial cardiac muscle cell communication The process that mediates interactions between an SA node cardiomyocyte and its surroundings that contributes to the process of the SA node cardiomyocyte communicating with an atrial cardiomyocyte in cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. RBO_relaxed.owl GO:0086067 biolink:NamedThing AV node cell to bundle of His cell communication The process that mediates interactions between an AV node cell and its surroundings that contributes to the process of the AV node cell communicating with a bundle of His cell in cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. RBO_relaxed.owl GO:0086068 biolink:NamedThing Purkinje myocyte to ventricular cardiac muscle cell communication The process that mediates interactions between a Purkinje myocyte and its surroundings that contributes to the process of the Purkinje myocyte communicating with a ventricular cardiac muscle cell in cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. RBO_relaxed.owl GO:0090685 biolink:NamedThing RNA localization to nucleus A macromolecular localization process in which RNA is transported to and maintained in a location within the nucleus. RBO_relaxed.owl GO:1990280 biolink:NamedThing RNA localization to chromatin A process in which RNA is transported to and maintained in a part of a chromosome that is organized into chromatin. RBO_relaxed.owl GO:0097512 biolink:NamedThing cardiac myofibril A cardiac myofibril is a myofibril specific to cardiac muscle cells. RBO_relaxed.owl GO:0097711 biolink:NamedThing ciliary basal body-plasma membrane docking The docking of a cytosolic centriole/basal body to the plasma membrane via the ciliary transition fibers. In some species this may happen via an intermediate step, by first docking to the ciliary vesicle via the ciliary transition fibers. The basal body-ciliary vesicle then relocates to the plasma membrane, followed by the ciliary vesicle fusing with the plasma membrane, effectively attaching the basal body to the plasma membrane. RBO_relaxed.owl GO:0097712 biolink:NamedThing vesicle targeting, trans-Golgi to periciliary membrane compartment The process in which vesicles formed at the trans-Golgi network are directed to the plasma membrane surrounding the base of the cilium, including the ciliary pocket, mediated by molecules at the vesicle membrane and target membrane surfaces. RBO_relaxed.owl GO:0097734 biolink:NamedThing extracellular exosome biogenesis The assembly and secretion of an extracellular exosome, a membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. RBO_relaxed.owl GO:0098645 biolink:NamedThing collagen network A supramolecular complex that consists of collagen triple helices associated to form a network. RBO_relaxed.owl GO:0099081 biolink:NamedThing supramolecular polymer A polymeric supramolecular structure. RBO_relaxed.owl GO:0098871 biolink:NamedThing postsynaptic actin cytoskeleton The actin cytoskeleton that is part of a postsynapse. RBO_relaxed.owl GO:0099143 biolink:NamedThing presynaptic actin cytoskeleton The actin cytoskeleton that is part of a presynapse. RBO_relaxed.owl GO:0099537 biolink:NamedThing trans-synaptic signaling Cell-cell signaling in either direction across the synaptic cleft. RBO_relaxed.owl GO:0098917 biolink:NamedThing retrograde trans-synaptic signaling Cell-cell signaling from post to pre-synapse, across the synaptic cleft. RBO_relaxed.owl GO:0098920 biolink:NamedThing retrograde trans-synaptic signaling by lipid Cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by a lipid ligand. RBO_relaxed.owl GO:0099082 biolink:NamedThing retrograde trans-synaptic signaling by neuropeptide Cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by a neuropeptide. RBO_relaxed.owl GO:0099083 biolink:NamedThing retrograde trans-synaptic signaling by neuropeptide, modulating synaptic transmission Modulation of synaptic transmittion by cell-cell signaling across the synaptic cleft from postsynapse to presynapse, mediated by a neuropeptide. RBO_relaxed.owl GO:0099157 biolink:NamedThing trans-synaptic signaling via exosome Transynaptic signaling in which the ligand is carried across the synapse by an exosome. RBO_relaxed.owl GO:0099540 biolink:NamedThing trans-synaptic signaling by neuropeptide Cell-cell signaling between presynapse and postsynapse mediated by a peptide ligand crossing the synaptic cleft. RBO_relaxed.owl GO:0099541 biolink:NamedThing trans-synaptic signaling by lipid Cell-cell signaling from post to pre-synapse, across the synaptic cleft, mediated by a lipid. RBO_relaxed.owl GO:0099551 biolink:NamedThing trans-synaptic signaling by neuropeptide, modulating synaptic transmission Cell-cell signaling between presynapse and postsynapse, via the vesicular release and reception of neuropeptide molecules, that modulates the synaptic transmission properties of the synapse. RBO_relaxed.owl GO:0099552 biolink:NamedThing trans-synaptic signaling by lipid, modulating synaptic transmission Cell-cell signaling between presynapse and postsynapse, via the release and reception of lipid molecules, that modulates the synaptic transmission properties of the synapse. RBO_relaxed.owl GO:0098992 biolink:NamedThing neuronal dense core vesicle A dense core vesicle (granule) that is part of a neuron. These vesicles typically contain neuropeptides. They can be found in all parts of neurons, including the soma, dendrites, axonal swellings (varicosities) and synaptic terminals. RBO_relaxed.owl GO:0099538 biolink:NamedThing synaptic signaling via neuropeptide Cell-cell signaling to or from a synapse, mediated by a peptide. RBO_relaxed.owl GO:0140236 biolink:NamedThing translation at presynapse Translation that occurs at the presynapse. RBO_relaxed.owl GO:0140237 biolink:NamedThing translation at presynapse, modulating chemical synaptic transmission Translation that occurs at the presynapse, and that modulates chemical synaptic transmission. RBO_relaxed.owl GO:0140241 biolink:NamedThing translation at synapse Translation that occurs at the synapse. RBO_relaxed.owl GO:0140242 biolink:NamedThing translation at postsynapse Translation that occurs at the postsynapse. RBO_relaxed.owl GO:0140961 biolink:NamedThing cellular detoxification of metal ion Any process carried out at the cellular level that reduces or removes the toxicity of a metal ion. RBO_relaxed.owl GO:1900116 biolink:NamedThing extracellular negative regulation of signal transduction Any negative regulation of signal transduction that takes place in extracellular region. RBO_relaxed.owl GO:1901148 biolink:NamedThing gene expression involved in extracellular matrix organization Any gene expression that is involved in extracellular matrix organization. Gene expression includes both transcription to produce an RNA transcript, and the translation of that mRNA into protein. Protein maturation is included in gene expression when required to form an active form of a product from an inactive precursor form. RBO_relaxed.owl GO:1904269 biolink:NamedThing cell leading edge cell cortex The cell cortex of the leading edge of a cell. RBO_relaxed.owl GO:1905427 biolink:NamedThing intracellular signal transduction involved in positive regulation of cell growth Any intracellular signal transduction that is involved in positive regulation of cell growth. RBO_relaxed.owl GO:1905720 biolink:NamedThing cytoplasmic microtubule bundle Any microtubule bundle that is part of a cytoplasm. RBO_relaxed.owl GO:1990768 biolink:NamedThing gastric mucosal blood circulation The flow of blood through the gastric mucosa of an animal, enabling the transport of nutrients and the removal of waste products. RBO_relaxed.owl OBO:HANCESTRO_0004 biolink:NamedThing ancestry category Population category defined using ancestry informative markers (AIMs) based on genetic/genomic data RBO_relaxed.owl OBO:HANCESTRO_0290 biolink:NamedThing genetically isolated population A population with increased genetic homogeneity and reduced genetic variation due to cultural or geographic isolation RBO_relaxed.owl OBO:HANCESTRO_0304 biolink:NamedThing ancestry status General characterisation of the ancestry of a population or individual RBO_relaxed.owl IAO:0000015 biolink:NamedThing information carrier A quality of an information bearer that imparts the information content RBO_relaxed.owl EFO:0004429 biolink:NamedThing inbred Property of an organism which indicates that the organism's parents were genetically related (potentially for several generations). Inbreeding results in closer homozygosity. RBO_relaxed.owl OBO:HANCESTRO_0305 biolink:NamedThing genetically isolated ancestry Ancestry that is the result of cultural or geographic isolation. Generally characterised by increased genetic homogeneity and reduced genetic variation RBO_relaxed.owl OBO:HANCESTRO_0306 biolink:NamedThing admixed ancestry Ancestry which is an admixture of more than one defined ancestral population. The degree and type of admixture may vary within a population and the accuracy of classification requires well-defined reference samples RBO_relaxed.owl IAO:0000003 biolink:NamedThing measurement unit label A measurement unit label is as a label that is part of a scalar measurement datum and denotes a unit of measure. RBO_relaxed.owl IAO:0000009 biolink:NamedThing datum label A label is a symbol that is part of some other datum and is used to either partially define the denotation of that datum or to provide a means for identifying the datum as a member of the set of data with the same label RBO_relaxed.owl OBI:0000963 biolink:NamedThing categorical label A label that is part of a categorical datum and that indicates the value of the data item on the categorical scale. RBO_relaxed.owl IAO:0000027 biolink:NamedThing data item An information content entity that is intended to be a truthful statement about something (modulo, e.g., measurement precision or other systematic errors) and is constructed/acquired by a method which reliably tends to produce (approximately) truthful statements.|a data item is an information content entity that is intended to be a truthful statement about something (modulo, e.g., measurement precision or other systematic errors) and is constructed/acquired by a method which reliably tends to produce (approximately) truthful statements. RBO_relaxed.owl IAO:0000308 biolink:NamedThing figure An information content entity consisting of a two dimensional arrangement of information content entities such that the arrangement itself is about something. RBO_relaxed.owl IAO:0000310 biolink:NamedThing document A collection of information content entities intended to be understood together as a whole RBO_relaxed.owl OBI:0001909 biolink:NamedThing conclusion based on data An information content entity that is inferred from data. RBO_relaxed.owl OBI:0001933 biolink:NamedThing value specification An information content entity that specifies a value within a classification scheme or on a quantitative scale. RBO_relaxed.owl OBO:RBO_00015009 biolink:NamedThing particle track The path of a particle in matter, delineated by sites where the particle deposits energy. RBO_relaxed.owl OBO:UO_0000000 biolink:NamedThing unit A unit of measurement is a standardized quantity of a physical quality. RBO_relaxed.owl IAO:0000010 biolink:NamedThing software Software is a plan specification composed of a series of instructions that can be interpreted by or directly executed by a processing unit. RBO_relaxed.owl IAO:0000064 biolink:NamedThing algorithm A plan specification which describes the inputs and output of mathematical functions as well as workflow of execution for achieving an predefined objective. Algorithms are realized usually by means of implementation as computer programs for execution by automata. RBO_relaxed.owl OBI:0000272 biolink:NamedThing protocol A plan specification which has sufficient level of detail and quantitative information to communicate it between investigation agents, so that different investigation agents will reliably be able to independently reproduce the process.|A protocol is an information entity which is a set of instructions that describe an how an experiment is done.|a protocol is a plan specification which has sufficient level of detail and quantitative information to communicate it between domain experts, so that different domain experts will reliably be able to independently reproduce the process. RBO_relaxed.owl OBO:RBO_00005016 biolink:NamedThing radiation fractionation protocol A protocol for administering a total radiation dose in two or more increments separated by a specified time interval RBO_relaxed.owl OBO:RBO_010000 biolink:NamedThing as low as reasonably achievable A principle of radiation protection philosophy that requires that exposures to ionizing radiation be kept as low as reasonably achievable, economic and social factors being taken into account. The protection from radiation exposure is ALARA when the expen RBO_relaxed.owl IAO:0000032 biolink:NamedThing scalar measurement datum A scalar measurement datum is a measurement datum that is composed of two parts, numerals and a unit label. RBO_relaxed.owl IAO:0000109 biolink:NamedThing measurement datum A measurement datum is an information content entity that is a recording of the output of a measurement such as produced by a device. RBO_relaxed.owl OBI:0000984 biolink:NamedThing dose A measurement datum that measures the quantity of something that may be administered to an organism or that an organism may be exposed to. Quantities of nutrients, drugs, vaccines and toxins are referred to as doses. RBO_relaxed.owl OBO:RBO_00000029 biolink:NamedThing dose rate The measurement datum representing a dose to an organism or object per unit time. RBO_relaxed.owl OBO:RBO_010010 biolink:NamedThing fluence The number of particles or photons per unit of cross-sectional area perpendicular to the direction of the particle (units of m^2 or cm^2) (i.e., particles-m^[-2] or particles-cm^[-2]). RBO_relaxed.owl OBO:RBO_010011 biolink:NamedThing flux The quotient of dN by dt, where dN is the increment of the particle number in the time interval dt. The unit for flux is reciprocal second (s^[-1].) RBO_relaxed.owl OBO:RBO_010013 biolink:NamedThing linear energy transfer The energy deposited by an ionizing charged particle or photon in any medium per unit path length. RBO_relaxed.owl OBO:RBO_010019 biolink:NamedThing relative biological effectiveness Factor used to compare the biological effectiveness of absorbed doses from different types of ionizing radiation, determined experimentally. RBE is the ratio of the absorbed dose of a reference radiation to the absorbed dose of the radiation in question r RBO_relaxed.owl IAO:0000037 biolink:NamedThing dot plot A dot plot is a report graph which is a graphical representation of data where each data point is represented by a single dot placed on coordinates corresponding to data point values in particular dimensions. RBO_relaxed.owl IAO:0000038 biolink:NamedThing graph A diagram that presents one or more tuples of information by mapping those tuples in to a two dimensional space in a non arbitrary way. RBO_relaxed.owl IAO:0000179 biolink:NamedThing histogram A histogram is a report graph which is a statistical description of a distribution in terms of occurrence frequencies of different event classes. RBO_relaxed.owl IAO:0000180 biolink:NamedThing heatmap A heatmap is a report graph which is a graphical representation of data where the values taken by a variable(s) are shown as colors in a two-dimensional map. RBO_relaxed.owl IAO:0000183 biolink:NamedThing dendrogram A dendrogram is a report graph which is a tree diagram frequently used to illustrate the arrangement of the clusters produced by a clustering algorithm. RBO_relaxed.owl IAO:0000184 biolink:NamedThing scatter plot A scatterplot is a graph which uses Cartesian coordinates to display values for two variables for a set of data. The data is displayed as a collection of points, each having the value of one variable determining the position on the horizontal axis and the value of the other variable determining the position on the vertical axis. RBO_relaxed.owl IAO:0000309 biolink:NamedThing diagram A figure that expresses one or more propositions RBO_relaxed.owl IAO:0000078 biolink:NamedThing curation status specification The curation status of the term. The allowed values come from an enumerated list of predefined terms. See the specification of these instances for more detailed definitions of each enumerated value. RBO_relaxed.owl IAO:0000102 biolink:NamedThing data about an ontology part Data about an ontology part is a data item about a part of an ontology, for example a term RBO_relaxed.owl IAO:0000225 biolink:NamedThing obsolescence reason specification The reason for which a term has been deprecated. The allowed values come from an enumerated list of predefined terms. See the specification of these instances for more detailed definitions of each enumerated value. RBO_relaxed.owl IAO:0000409 biolink:NamedThing denotator type A denotator type indicates how a term should be interpreted from an ontological perspective. RBO_relaxed.owl IAO:0000101 biolink:NamedThing image An image is an affine projection to a two dimensional surface, of measurements of some quality of an entity or entities repeated at regular intervals across a spatial range, where the measurements are represented as color and luminosity on the projected on surface. RBO_relaxed.owl IAO:0000408 biolink:NamedThing length measurement datum A scalar measurement datum that is the result of measurement of length quality RBO_relaxed.owl NBO:0000001 biolink:NamedThing body part movement A change of place or position of part of an organism that does not involve the entire organism [NBO:SMAC] RBO_relaxed.owl NBO:0000338 biolink:NamedThing kinesthetic behavior "Movement behavior of the body or its parts." RBO_relaxed.owl NBO:0000007 biolink:NamedThing mouth movement The act of moving any of the tissues and hard structures surrounding the mouth other than teeth, jaws or filter structures [NBO:AC] RBO_relaxed.owl NBO:0000073 biolink:NamedThing chewing The act of repeated grinding, tearing, and or crushing with teeth or jaws [NBO:SMAC] RBO_relaxed.owl NBO:0000747 biolink:NamedThing jaw movement RBO_relaxed.owl NBO:0001786 biolink:NamedThing regulation of behavior "Any process that modulates the frequency, rate or extent of behavior, the specific actions or reactions of an organism in response to external or internal stimuli." [GO:0050795] RBO_relaxed.owl NCBITaxon:1 biolink:NamedThing root RBO_relaxed.owl NCBITaxon:10239 biolink:NamedThing Viruses RBO_relaxed.owl NCBITaxon:10026 biolink:NamedThing Cricetinae RBO_relaxed.owl NCBITaxon:337677 biolink:NamedThing Cricetidae RBO_relaxed.owl NCBITaxon:40141 biolink:NamedThing Sigmodontinae RBO_relaxed.owl NCBITaxon:10035 biolink:NamedThing Mesocricetus RBO_relaxed.owl NCBITaxon:10066 biolink:NamedThing Muridae RBO_relaxed.owl NCBITaxon:337687 biolink:NamedThing Muroidea RBO_relaxed.owl NCBITaxon:10088 biolink:NamedThing Mus Mus (commonly mice) is a small mammal belonging to the order of rodents. RBO_relaxed.owl NCBITaxon:39107 biolink:NamedThing Murinae RBO_relaxed.owl NCBITaxon:10114 biolink:NamedThing Rattus RBO_relaxed.owl NCBITaxon:10089 biolink:NamedThing Mus caroli RBO_relaxed.owl NCBITaxon:10096 biolink:NamedThing Mus spretus RBO_relaxed.owl NCBITaxon:862507 biolink:NamedThing Mus RBO_relaxed.owl NCBITaxon:10090 biolink:NamedThing Mus musculus RBO_relaxed.owl NCBITaxon:104431 biolink:NamedThing Obtectomera RBO_relaxed.owl NCBITaxon:37567 biolink:NamedThing Ditrysia RBO_relaxed.owl NCBITaxon:1046325 biolink:NamedThing Lumbricinae RBO_relaxed.owl NCBITaxon:6392 biolink:NamedThing Lumbricidae RBO_relaxed.owl NCBITaxon:1050931 biolink:NamedThing Lumbricus terrestris complex RBO_relaxed.owl NCBITaxon:6397 biolink:NamedThing Lumbricus RBO_relaxed.owl NCBITaxon:1050932 biolink:NamedThing Lumbricus rubellus complex RBO_relaxed.owl NCBITaxon:105389 biolink:NamedThing Sedentaria RBO_relaxed.owl NCBITaxon:6341 biolink:NamedThing Polychaeta RBO_relaxed.owl NCBITaxon:105391 biolink:NamedThing Canalipalpata RBO_relaxed.owl NCBITaxon:110814 biolink:NamedThing Xenoturbellida RBO_relaxed.owl NCBITaxon:1312402 biolink:NamedThing Xenacoelomorpha RBO_relaxed.owl NCBITaxon:147099 biolink:NamedThing Acoelomorpha RBO_relaxed.owl NCBITaxon:110815 biolink:NamedThing Xenoturbella RBO_relaxed.owl NCBITaxon:1547233 biolink:NamedThing Xenoturbellidae RBO_relaxed.owl NCBITaxon:116556 biolink:NamedThing Sarsostraca RBO_relaxed.owl NCBITaxon:6658 biolink:NamedThing Branchiopoda RBO_relaxed.owl NCBITaxon:116557 biolink:NamedThing Phyllopoda RBO_relaxed.owl NCBITaxon:116561 biolink:NamedThing Anomopoda RBO_relaxed.owl NCBITaxon:6665 biolink:NamedThing Cladocera RBO_relaxed.owl NCBITaxon:116704 biolink:NamedThing Eubrachyura RBO_relaxed.owl NCBITaxon:6752 biolink:NamedThing Brachyura RBO_relaxed.owl NCBITaxon:116706 biolink:NamedThing Heterotremata RBO_relaxed.owl NCBITaxon:117565 biolink:NamedThing Myxini RBO_relaxed.owl NCBITaxon:1476529 biolink:NamedThing Cyclostomata RBO_relaxed.owl NCBITaxon:117570 biolink:NamedThing Teleostomi RBO_relaxed.owl NCBITaxon:7776 biolink:NamedThing Gnathostomata RBO_relaxed.owl NCBITaxon:7777 biolink:NamedThing Chondrichthyes RBO_relaxed.owl NCBITaxon:117571 biolink:NamedThing Euteleostomi RBO_relaxed.owl NCBITaxon:119089 biolink:NamedThing Chromadorea RBO_relaxed.owl NCBITaxon:6231 biolink:NamedThing Nematoda RBO_relaxed.owl NCBITaxon:1206794 biolink:NamedThing Ecdysozoa RBO_relaxed.owl NCBITaxon:33317 biolink:NamedThing Protostomia RBO_relaxed.owl NCBITaxon:2697495 biolink:NamedThing Spiralia RBO_relaxed.owl NCBITaxon:1206795 biolink:NamedThing Lophotrochozoa RBO_relaxed.owl NCBITaxon:123365 biolink:NamedThing Neoteleostei RBO_relaxed.owl NCBITaxon:1489388 biolink:NamedThing Euteleosteomorpha RBO_relaxed.owl NCBITaxon:41705 biolink:NamedThing Protacanthopterygii RBO_relaxed.owl NCBITaxon:123366 biolink:NamedThing Eurypterygia RBO_relaxed.owl NCBITaxon:123367 biolink:NamedThing Ctenosquamata RBO_relaxed.owl NCBITaxon:123368 biolink:NamedThing Acanthomorphata RBO_relaxed.owl NCBITaxon:123369 biolink:NamedThing Euacanthomorphacea RBO_relaxed.owl NCBITaxon:124129 biolink:NamedThing Acipenserinae RBO_relaxed.owl NCBITaxon:7900 biolink:NamedThing Acipenseridae RBO_relaxed.owl NCBITaxon:124130 biolink:NamedThing Acipenserini RBO_relaxed.owl NCBITaxon:131209 biolink:NamedThing Zygnemophyceae RBO_relaxed.owl NCBITaxon:131221 biolink:NamedThing Streptophytina RBO_relaxed.owl NCBITaxon:3193 biolink:NamedThing Embryophyta RBO_relaxed.owl NCBITaxon:35493 biolink:NamedThing Streptophyta RBO_relaxed.owl NCBITaxon:33511 biolink:NamedThing Deuterostomia RBO_relaxed.owl NCBITaxon:1329799 biolink:NamedThing Archelosauria RBO_relaxed.owl NCBITaxon:32561 biolink:NamedThing Sauria RBO_relaxed.owl NCBITaxon:1338369 biolink:NamedThing Dipnotetrapodomorpha RBO_relaxed.owl NCBITaxon:8287 biolink:NamedThing Sarcopterygii RBO_relaxed.owl NCBITaxon:2605435 biolink:NamedThing Evosea RBO_relaxed.owl NCBITaxon:1437010 biolink:NamedThing Boreoeutheria RBO_relaxed.owl NCBITaxon:9347 biolink:NamedThing Eutheria RBO_relaxed.owl NCBITaxon:1437180 biolink:NamedThing Acrogymnospermae RBO_relaxed.owl NCBITaxon:58024 biolink:NamedThing Spermatophyta RBO_relaxed.owl NCBITaxon:3398 biolink:NamedThing Magnoliopsida RBO_relaxed.owl NCBITaxon:1437183 biolink:NamedThing Mesangiospermae RBO_relaxed.owl NCBITaxon:1437197 biolink:NamedThing Petrosaviidae RBO_relaxed.owl NCBITaxon:4447 biolink:NamedThing Liliopsida RBO_relaxed.owl NCBITaxon:1445966 biolink:NamedThing Gnetidae RBO_relaxed.owl NCBITaxon:3372 biolink:NamedThing Gnetopsida RBO_relaxed.owl NCBITaxon:1446380 biolink:NamedThing Pinales RBO_relaxed.owl NCBITaxon:2821352 biolink:NamedThing Conifers I RBO_relaxed.owl NCBITaxon:716545 biolink:NamedThing saccharomyceta RBO_relaxed.owl NCBITaxon:147554 biolink:NamedThing Schizosaccharomycetes RBO_relaxed.owl NCBITaxon:451866 biolink:NamedThing Taphrinomycotina RBO_relaxed.owl NCBITaxon:1489341 biolink:NamedThing Osteoglossocephalai RBO_relaxed.owl NCBITaxon:186625 biolink:NamedThing Clupeocephala RBO_relaxed.owl NCBITaxon:186634 biolink:NamedThing Otomorpha RBO_relaxed.owl NCBITaxon:1489872 biolink:NamedThing Percomorphaceae RBO_relaxed.owl NCBITaxon:1489904 biolink:NamedThing Carangaria RBO_relaxed.owl NCBITaxon:1489922 biolink:NamedThing Eupercaria RBO_relaxed.owl NCBITaxon:1549675 biolink:NamedThing Galloanserae RBO_relaxed.owl NCBITaxon:8825 biolink:NamedThing Neognathae RBO_relaxed.owl NCBITaxon:8929 biolink:NamedThing Columbiformes RBO_relaxed.owl NCBITaxon:168636 biolink:NamedThing Eisenia andrei RBO_relaxed.owl NCBITaxon:6393 biolink:NamedThing Eisenia RBO_relaxed.owl NCBITaxon:6396 biolink:NamedThing Eisenia fetida RBO_relaxed.owl NCBITaxon:186622 biolink:NamedThing Acipenseroidei RBO_relaxed.owl NCBITaxon:7899 biolink:NamedThing Acipenseriformes RBO_relaxed.owl NCBITaxon:186623 biolink:NamedThing Actinopteri RBO_relaxed.owl NCBITaxon:7898 biolink:NamedThing Actinopterygii RBO_relaxed.owl NCBITaxon:186626 biolink:NamedThing Otophysi RBO_relaxed.owl NCBITaxon:32519 biolink:NamedThing Ostariophysi RBO_relaxed.owl NCBITaxon:186627 biolink:NamedThing Cypriniphysae RBO_relaxed.owl NCBITaxon:1963758 biolink:NamedThing Myomorpha RBO_relaxed.owl NCBITaxon:9989 biolink:NamedThing Rodentia RBO_relaxed.owl NCBITaxon:1964463 biolink:NamedThing Enchytraeida RBO_relaxed.owl NCBITaxon:6381 biolink:NamedThing Oligochaeta RBO_relaxed.owl NCBITaxon:2803884 biolink:NamedThing Crassiclitellata RBO_relaxed.owl NCBITaxon:197562 biolink:NamedThing Pancrustacea RBO_relaxed.owl NCBITaxon:197563 biolink:NamedThing Mandibulata RBO_relaxed.owl NCBITaxon:2157 biolink:NamedThing Archaea RBO_relaxed.owl NCBITaxon:2058185 biolink:NamedThing Dictyosteliaceae RBO_relaxed.owl NCBITaxon:2058949 biolink:NamedThing Dictyosteliales RBO_relaxed.owl NCBITaxon:33083 biolink:NamedThing Dictyostelia RBO_relaxed.owl NCBITaxon:207598 biolink:NamedThing Homininae RBO_relaxed.owl NCBITaxon:9604 biolink:NamedThing Hominidae RBO_relaxed.owl NCBITaxon:2172821 biolink:NamedThing Multicrustacea RBO_relaxed.owl NCBITaxon:6657 biolink:NamedThing Crustacea RBO_relaxed.owl NCBITaxon:2218736 biolink:NamedThing Hirudinida RBO_relaxed.owl NCBITaxon:55824 biolink:NamedThing Hirudinea RBO_relaxed.owl NCBITaxon:2301116 biolink:NamedThing Rhabditina RBO_relaxed.owl NCBITaxon:6236 biolink:NamedThing Rhabditida RBO_relaxed.owl NCBITaxon:2301119 biolink:NamedThing Rhabditomorpha RBO_relaxed.owl NCBITaxon:554915 biolink:NamedThing Amoebozoa RBO_relaxed.owl NCBITaxon:2611352 biolink:NamedThing Discoba RBO_relaxed.owl NCBITaxon:2698737 biolink:NamedThing Sar RBO_relaxed.owl NCBITaxon:38254 biolink:NamedThing Glaucocystophyceae RBO_relaxed.owl NCBITaxon:262014 biolink:NamedThing Xenopus RBO_relaxed.owl NCBITaxon:8353 biolink:NamedThing Xenopus RBO_relaxed.owl NCBITaxon:2684882 biolink:NamedThing Zygnematophycidae RBO_relaxed.owl NCBITaxon:2696291 biolink:NamedThing Ochrophyta RBO_relaxed.owl NCBITaxon:33634 biolink:NamedThing Stramenopiles RBO_relaxed.owl NCBITaxon:2743709 biolink:NamedThing Danionidae RBO_relaxed.owl NCBITaxon:30727 biolink:NamedThing Cyprinoidei RBO_relaxed.owl NCBITaxon:2743711 biolink:NamedThing Danioninae RBO_relaxed.owl NCBITaxon:27592 biolink:NamedThing Bovinae RBO_relaxed.owl NCBITaxon:9895 biolink:NamedThing Bovidae RBO_relaxed.owl NCBITaxon:9963 biolink:NamedThing Caprinae RBO_relaxed.owl NCBITaxon:3313 biolink:NamedThing Pinidae RBO_relaxed.owl NCBITaxon:2870 biolink:NamedThing Phaeophyceae RBO_relaxed.owl NCBITaxon:569578 biolink:NamedThing PX clade RBO_relaxed.owl NCBITaxon:29122 biolink:NamedThing Oryzomys RBO_relaxed.owl NCBITaxon:29964 biolink:NamedThing Cancroidea RBO_relaxed.owl NCBITaxon:30319 biolink:NamedThing Pipoidea RBO_relaxed.owl NCBITaxon:8342 biolink:NamedThing Anura RBO_relaxed.owl NCBITaxon:8416 biolink:NamedThing Neobatrachia RBO_relaxed.owl NCBITaxon:30352 biolink:NamedThing Ranoidea RBO_relaxed.owl NCBITaxon:3042114 biolink:NamedThing Anthophila RBO_relaxed.owl NCBITaxon:34735 biolink:NamedThing Apoidea RBO_relaxed.owl NCBITaxon:7952 biolink:NamedThing Cypriniformes RBO_relaxed.owl NCBITaxon:30942 biolink:NamedThing Pleuronectoidei RBO_relaxed.owl NCBITaxon:8252 biolink:NamedThing Pleuronectiformes RBO_relaxed.owl NCBITaxon:31022 biolink:NamedThing Tetraodontiformes RBO_relaxed.owl NCBITaxon:31028 biolink:NamedThing Tetraodontoidei RBO_relaxed.owl NCBITaxon:31031 biolink:NamedThing Tetraodontidae RBO_relaxed.owl NCBITaxon:32517 biolink:NamedThing Tetradontoidea RBO_relaxed.owl NCBITaxon:31032 biolink:NamedThing Takifugu RBO_relaxed.owl NCBITaxon:31033 biolink:NamedThing Takifugu rubripes RBO_relaxed.owl NCBITaxon:314145 biolink:NamedThing Laurasiatheria RBO_relaxed.owl NCBITaxon:314146 biolink:NamedThing Euarchontoglires RBO_relaxed.owl NCBITaxon:314147 biolink:NamedThing Glires RBO_relaxed.owl NCBITaxon:9443 biolink:NamedThing Primates RBO_relaxed.owl NCBITaxon:314293 biolink:NamedThing Simiiformes RBO_relaxed.owl NCBITaxon:376913 biolink:NamedThing Haplorrhini RBO_relaxed.owl NCBITaxon:314294 biolink:NamedThing Cercopithecoidea RBO_relaxed.owl NCBITaxon:9526 biolink:NamedThing Catarrhini RBO_relaxed.owl NCBITaxon:314295 biolink:NamedThing Hominoidea RBO_relaxed.owl NCBITaxon:3176 biolink:NamedThing Zygnematales RBO_relaxed.owl NCBITaxon:3208 biolink:NamedThing Bryophyta RBO_relaxed.owl NCBITaxon:58023 biolink:NamedThing Tracheophyta RBO_relaxed.owl NCBITaxon:32341 biolink:NamedThing Sophophora RBO_relaxed.owl NCBITaxon:7215 biolink:NamedThing Drosophila RBO_relaxed.owl NCBITaxon:32346 biolink:NamedThing melanogaster group RBO_relaxed.owl NCBITaxon:32351 biolink:NamedThing melanogaster subgroup RBO_relaxed.owl NCBITaxon:32440 biolink:NamedThing Chondrostei RBO_relaxed.owl NCBITaxon:41665 biolink:NamedThing Neopterygii RBO_relaxed.owl NCBITaxon:32523 biolink:NamedThing Tetrapoda RBO_relaxed.owl NCBITaxon:7878 biolink:NamedThing Dipnomorpha RBO_relaxed.owl NCBITaxon:32524 biolink:NamedThing Amniota RBO_relaxed.owl NCBITaxon:8292 biolink:NamedThing Amphibia RBO_relaxed.owl NCBITaxon:40674 biolink:NamedThing Mammalia RBO_relaxed.owl NCBITaxon:9254 biolink:NamedThing Prototheria RBO_relaxed.owl NCBITaxon:8457 biolink:NamedThing Sauropsida RBO_relaxed.owl NCBITaxon:3312 biolink:NamedThing Coniferophyta RBO_relaxed.owl NCBITaxon:58019 biolink:NamedThing Pinopsida RBO_relaxed.owl NCBITaxon:3318 biolink:NamedThing Pinaceae RBO_relaxed.owl NCBITaxon:6073 biolink:NamedThing Cnidaria RBO_relaxed.owl NCBITaxon:33340 biolink:NamedThing Neoptera RBO_relaxed.owl NCBITaxon:7496 biolink:NamedThing Pterygota RBO_relaxed.owl NCBITaxon:33392 biolink:NamedThing Endopterygota RBO_relaxed.owl NCBITaxon:33554 biolink:NamedThing Carnivora RBO_relaxed.owl NCBITaxon:91561 biolink:NamedThing Artiodactyla RBO_relaxed.owl NCBITaxon:33630 biolink:NamedThing Alveolata RBO_relaxed.owl NCBITaxon:33682 biolink:NamedThing Euglenozoa RBO_relaxed.owl NCBITaxon:3378 biolink:NamedThing Gnetales RBO_relaxed.owl NCBITaxon:338152 biolink:NamedThing Felinae RBO_relaxed.owl NCBITaxon:9681 biolink:NamedThing Felidae RBO_relaxed.owl NCBITaxon:34346 biolink:NamedThing Schizosaccharomycetales RBO_relaxed.owl NCBITaxon:7434 biolink:NamedThing Aculeata RBO_relaxed.owl NCBITaxon:35497 biolink:NamedThing Suina RBO_relaxed.owl NCBITaxon:9845 biolink:NamedThing Ruminantia RBO_relaxed.owl NCBITaxon:35500 biolink:NamedThing Pecora RBO_relaxed.owl NCBITaxon:41197 biolink:NamedThing Heteroneura RBO_relaxed.owl NCBITaxon:37572 biolink:NamedThing Papilionoidea RBO_relaxed.owl NCBITaxon:379583 biolink:NamedThing Feliformia RBO_relaxed.owl NCBITaxon:379584 biolink:NamedThing Caniformia RBO_relaxed.owl NCBITaxon:38009 biolink:NamedThing Artemiidae RBO_relaxed.owl NCBITaxon:6659 biolink:NamedThing Anostraca RBO_relaxed.owl NCBITaxon:38820 biolink:NamedThing Poales RBO_relaxed.owl NCBITaxon:4734 biolink:NamedThing commelinids RBO_relaxed.owl NCBITaxon:41191 biolink:NamedThing Glossata RBO_relaxed.owl NCBITaxon:7088 biolink:NamedThing Lepidoptera RBO_relaxed.owl NCBITaxon:41196 biolink:NamedThing Neolepidoptera RBO_relaxed.owl NCBITaxon:41324 biolink:NamedThing Siboglinidae RBO_relaxed.owl NCBITaxon:6362 biolink:NamedThing Sabellida RBO_relaxed.owl NCBITaxon:41666 biolink:NamedThing Batrachia RBO_relaxed.owl NCBITaxon:42113 biolink:NamedThing Clitellata RBO_relaxed.owl NCBITaxon:6340 biolink:NamedThing Annelida RBO_relaxed.owl NCBITaxon:436486 biolink:NamedThing Dinosauria RBO_relaxed.owl NCBITaxon:8492 biolink:NamedThing Archosauria RBO_relaxed.owl NCBITaxon:436489 biolink:NamedThing Saurischia RBO_relaxed.owl NCBITaxon:436491 biolink:NamedThing Theropoda RBO_relaxed.owl NCBITaxon:436492 biolink:NamedThing Coelurosauria RBO_relaxed.owl NCBITaxon:43733 biolink:NamedThing Muscomorpha RBO_relaxed.owl NCBITaxon:7203 biolink:NamedThing Brachycera RBO_relaxed.owl NCBITaxon:43738 biolink:NamedThing Schizophora RBO_relaxed.owl NCBITaxon:480117 biolink:NamedThing Cyclorrhapha RBO_relaxed.owl NCBITaxon:43741 biolink:NamedThing Acalyptratae RBO_relaxed.owl NCBITaxon:43746 biolink:NamedThing Ephydroidea RBO_relaxed.owl NCBITaxon:43845 biolink:NamedThing Drosophilinae RBO_relaxed.owl NCBITaxon:7214 biolink:NamedThing Drosophilidae RBO_relaxed.owl NCBITaxon:4479 biolink:NamedThing Poaceae RBO_relaxed.owl NCBITaxon:451864 biolink:NamedThing Dikarya RBO_relaxed.owl NCBITaxon:4890 biolink:NamedThing Ascomycota RBO_relaxed.owl NCBITaxon:46877 biolink:NamedThing Drosophilini RBO_relaxed.owl NCBITaxon:480118 biolink:NamedThing Eremoneura RBO_relaxed.owl NCBITaxon:4891 biolink:NamedThing Saccharomycetes RBO_relaxed.owl NCBITaxon:4892 biolink:NamedThing Saccharomycetales RBO_relaxed.owl NCBITaxon:4893 biolink:NamedThing Saccharomycetaceae RBO_relaxed.owl NCBITaxon:4894 biolink:NamedThing Schizosaccharomycetaceae RBO_relaxed.owl NCBITaxon:4895 biolink:NamedThing Schizosaccharomyces RBO_relaxed.owl NCBITaxon:4896 biolink:NamedThing Schizosaccharomyces pombe RBO_relaxed.owl NCBITaxon:4930 biolink:NamedThing Saccharomyces RBO_relaxed.owl NCBITaxon:4932 biolink:NamedThing Saccharomyces cerevisiae RBO_relaxed.owl NCBITaxon:504568 biolink:NamedThing Salmoninae RBO_relaxed.owl NCBITaxon:8015 biolink:NamedThing Salmonidae RBO_relaxed.owl NCBITaxon:6960 biolink:NamedThing Hexapoda RBO_relaxed.owl NCBITaxon:55879 biolink:NamedThing Rhabditoidea RBO_relaxed.owl NCBITaxon:55885 biolink:NamedThing Peloderinae RBO_relaxed.owl NCBITaxon:6243 biolink:NamedThing Rhabditidae RBO_relaxed.owl NCBITaxon:5782 biolink:NamedThing Dictyostelium RBO_relaxed.owl NCBITaxon:78536 biolink:NamedThing Euphyllophyta RBO_relaxed.owl NCBITaxon:6040 biolink:NamedThing Porifera RBO_relaxed.owl NCBITaxon:6157 biolink:NamedThing Platyhelminthes RBO_relaxed.owl NCBITaxon:6447 biolink:NamedThing Mollusca RBO_relaxed.owl NCBITaxon:88770 biolink:NamedThing Panarthropoda RBO_relaxed.owl NCBITaxon:6237 biolink:NamedThing Caenorhabditis RBO_relaxed.owl NCBITaxon:6239 biolink:NamedThing Caenorhabditis elegans RBO_relaxed.owl NCBITaxon:6388 biolink:NamedThing Enchytraeidae RBO_relaxed.owl NCBITaxon:6389 biolink:NamedThing Enchytraeus RBO_relaxed.owl NCBITaxon:6391 biolink:NamedThing Lumbricina RBO_relaxed.owl NCBITaxon:6398 biolink:NamedThing Lumbricus terrestris RBO_relaxed.owl NCBITaxon:6416 biolink:NamedThing Hirudiniformes RBO_relaxed.owl NCBITaxon:6417 biolink:NamedThing Hirudinidae RBO_relaxed.owl NCBITaxon:6660 biolink:NamedThing Artemia RBO_relaxed.owl NCBITaxon:84337 biolink:NamedThing Diplostraca RBO_relaxed.owl NCBITaxon:6668 biolink:NamedThing Daphnia RBO_relaxed.owl NCBITaxon:77658 biolink:NamedThing Daphniidae RBO_relaxed.owl NCBITaxon:6681 biolink:NamedThing Malacostraca RBO_relaxed.owl NCBITaxon:6682 biolink:NamedThing Eucarida RBO_relaxed.owl NCBITaxon:72041 biolink:NamedThing Eumalacostraca RBO_relaxed.owl NCBITaxon:6683 biolink:NamedThing Decapoda RBO_relaxed.owl NCBITaxon:6692 biolink:NamedThing Pleocyemata RBO_relaxed.owl NCBITaxon:6753 biolink:NamedThing Cancridae RBO_relaxed.owl NCBITaxon:85604 biolink:NamedThing Amphiesmenoptera RBO_relaxed.owl NCBITaxon:7147 biolink:NamedThing Diptera RBO_relaxed.owl NCBITaxon:7399 biolink:NamedThing Hymenoptera RBO_relaxed.owl NCBITaxon:7227 biolink:NamedThing Drosophila melanogaster RBO_relaxed.owl NCBITaxon:7400 biolink:NamedThing Apocrita RBO_relaxed.owl NCBITaxon:7458 biolink:NamedThing Apidae RBO_relaxed.owl NCBITaxon:85512 biolink:NamedThing Dicondylia RBO_relaxed.owl NCBITaxon:7712 biolink:NamedThing Tunicata RBO_relaxed.owl NCBITaxon:7761 biolink:NamedThing Myxiniformes RBO_relaxed.owl NCBITaxon:7762 biolink:NamedThing Myxinidae RBO_relaxed.owl NCBITaxon:7863 biolink:NamedThing Holocephali RBO_relaxed.owl NCBITaxon:7864 biolink:NamedThing Chimaeriformes RBO_relaxed.owl NCBITaxon:7901 biolink:NamedThing Acipenser RBO_relaxed.owl NCBITaxon:7954 biolink:NamedThing Danio RBO_relaxed.owl NCBITaxon:7955 biolink:NamedThing Danio rerio RBO_relaxed.owl NCBITaxon:8006 biolink:NamedThing Salmoniformes RBO_relaxed.owl NCBITaxon:8016 biolink:NamedThing Oncorhynchus RBO_relaxed.owl NCBITaxon:8028 biolink:NamedThing Salmo RBO_relaxed.owl NCBITaxon:8256 biolink:NamedThing Pleuronectidae RBO_relaxed.owl NCBITaxon:8352 biolink:NamedThing Pipidae RBO_relaxed.owl NCBITaxon:8360 biolink:NamedThing Xenopodinae RBO_relaxed.owl NCBITaxon:8355 biolink:NamedThing Xenopus laevis RBO_relaxed.owl NCBITaxon:8397 biolink:NamedThing Ranidae RBO_relaxed.owl NCBITaxon:85549 biolink:NamedThing Artemia salina RBO_relaxed.owl NCBITaxon:8782 biolink:NamedThing Aves RBO_relaxed.owl NCBITaxon:8783 biolink:NamedThing Palaeognathae RBO_relaxed.owl NCBITaxon:8798 biolink:NamedThing Struthioniformes RBO_relaxed.owl NCBITaxon:8799 biolink:NamedThing Struthionidae RBO_relaxed.owl NCBITaxon:8800 biolink:NamedThing Struthio RBO_relaxed.owl NCBITaxon:8801 biolink:NamedThing Struthio camelus RBO_relaxed.owl NCBITaxon:8826 biolink:NamedThing Anseriformes RBO_relaxed.owl NCBITaxon:8976 biolink:NamedThing Galliformes RBO_relaxed.owl NCBITaxon:8830 biolink:NamedThing Anatidae RBO_relaxed.owl NCBITaxon:8930 biolink:NamedThing Columbidae RBO_relaxed.owl NCBITaxon:9005 biolink:NamedThing Phasianidae RBO_relaxed.owl NCBITaxon:9030 biolink:NamedThing Gallus RBO_relaxed.owl NCBITaxon:9072 biolink:NamedThing Phasianinae RBO_relaxed.owl NCBITaxon:9031 biolink:NamedThing Gallus gallus RBO_relaxed.owl NCBITaxon:913645 biolink:NamedThing Enchytraeus crypticus RBO_relaxed.owl NCBITaxon:9255 biolink:NamedThing Monotremata RBO_relaxed.owl NCBITaxon:9259 biolink:NamedThing Tachyglossidae RBO_relaxed.owl NCBITaxon:9479 biolink:NamedThing Platyrrhini RBO_relaxed.owl NCBITaxon:9527 biolink:NamedThing Cercopithecidae RBO_relaxed.owl NCBITaxon:9528 biolink:NamedThing Cercopithecinae RBO_relaxed.owl NCBITaxon:9539 biolink:NamedThing Macaca RBO_relaxed.owl NCBITaxon:9544 biolink:NamedThing Macaca mulatta RBO_relaxed.owl NCBITaxon:9605 biolink:NamedThing Homo RBO_relaxed.owl NCBITaxon:9608 biolink:NamedThing Canidae RBO_relaxed.owl NCBITaxon:9611 biolink:NamedThing Canis RBO_relaxed.owl NCBITaxon:9625 biolink:NamedThing Vulpes RBO_relaxed.owl NCBITaxon:9682 biolink:NamedThing Felis RBO_relaxed.owl NCBITaxon:9685 biolink:NamedThing Felis catus RBO_relaxed.owl NCBITaxon:9821 biolink:NamedThing Suidae RBO_relaxed.owl NCBITaxon:9822 biolink:NamedThing Sus RBO_relaxed.owl NCBITaxon:9850 biolink:NamedThing Cervidae RBO_relaxed.owl NCBITaxon:9869 biolink:NamedThing Rangifer RBO_relaxed.owl NCBITaxon:9881 biolink:NamedThing Odocoileinae RBO_relaxed.owl NCBITaxon:9903 biolink:NamedThing Bos RBO_relaxed.owl NCBITaxon:9913 biolink:NamedThing Bos taurus RBO_relaxed.owl NCBITaxon:9935 biolink:NamedThing Ovis RBO_relaxed.owl NCBITaxon:9940 biolink:NamedThing Ovis aries RBO_relaxed.owl NCBITaxon:9975 biolink:NamedThing Lagomorpha RBO_relaxed.owl OBI:0000014 biolink:NamedThing regulator role a regulatory role involved with making and/or enforcing relevant legislation and governmental orders RBO_relaxed.owl OBI:0000018 biolink:NamedThing material supplier role a role realized through the process of supplying materials such as animal subjects, reagents or other materials used in an investigation. RBO_relaxed.owl OBI:0000023 biolink:NamedThing classified data set A data set that is produced as the output of a class prediction data transformation and consists of a data set with assigned class labels. RBO_relaxed.owl OBI:0000648 biolink:NamedThing clustered data set A data set that is produced as the output of a class discovery data transformation and consists of a data set with assigned discovered class labels. RBO_relaxed.owl OBI:0000367 biolink:NamedThing light emission function A light emission function is an excitation function to excite a material to a specific excitation state that it emits light. RBO_relaxed.owl OBI:0000374 biolink:NamedThing excitation function A excitation function is a function to inject energy by bombarding a material with energetic particles (e.g., photons) thereby imbuing internal material components such as electrons with additional energy. These internal, 'excited' particles may lead to the rupturing of covalent chemical bonds or may quickly relax back to there unexcited state with an exponential time course thereby locally emitting energy in the form of photons. RBO_relaxed.owl OBI:0000450 biolink:NamedThing regulatory agency A regulatory agency is a organization that has responsibility over or for the legislation (acts and regulations) for a given sector of the government. RBO_relaxed.owl OBI:0000456 biolink:NamedThing material transformation objective an objective specifiction that creates an specific output object from input materials. RBO_relaxed.owl OBI:0000684 biolink:NamedThing specimen collection objective A objective specification to obtain a material entity for potential use as an input during an investigation. RBO_relaxed.owl OBI:0200166 biolink:NamedThing data transformation objective An objective specification to transformation input data into output data RBO_relaxed.owl OBI:0000457 biolink:NamedThing manufacturing A planned process with the objective to produce a processed material which will have a function for future use. RBO_relaxed.owl OBI:0302889 biolink:NamedThing planned irradiation A planned process by which a material entity is exposed to radiative energy, which could be ionizing radiation (such as gamma rays, X-rays, charged particles or neutrons) or non-ionizing radiation (such as UV light or microwaves) RBO_relaxed.owl OBI:0000458 biolink:NamedThing manufacturing objective is the objective to manufacture a material of a certain function (device) RBO_relaxed.owl OBI:0000663 biolink:NamedThing class prediction data transformation A class prediction data transformation (sometimes called supervised classification) is a data transformation that has objective class prediction. RBO_relaxed.owl OBI:0000707 biolink:NamedThing decision tree building data transformation A decision tree building data transformation is a data transformation that has objective decision tree induction. RBO_relaxed.owl OBI:0000726 biolink:NamedThing peak matching Peak matching is a data transformation performed on a dataset of a graph of ordered data points (e.g. a spectrum) with the objective of pattern matching local maxima above a noise threshold RBO_relaxed.owl OBI:0200171 biolink:NamedThing partitioning data transformation A partitioning data transformation is a data transformation that has objective partitioning. RBO_relaxed.owl OBI:0200175 biolink:NamedThing class discovery data transformation A class discovery data transformation (sometimes called unsupervised classification) is a data transformation that has objective class discovery. RBO_relaxed.owl OBI:0000700 biolink:NamedThing support vector machine A support vector machine is a data transformation with a class prediction objective based on the construction of a separating hyperplane that maximizes the margin between two data sets of vectors in n-dimensional space. RBO_relaxed.owl OBI:0000704 biolink:NamedThing decision tree induction objective A decision tree induction objective is a data transformation objective in which a tree-like graph of edges and nodes is created and from which the selection of each branch requires that some type of logical decision is made. RBO_relaxed.owl OBI:0200172 biolink:NamedThing partitioning objective A partitioning objective is a data transformation objective where the aim is to generate a collection of disjoint non-empty subsets whose union equals a non-empty input set. RBO_relaxed.owl OBI:0200178 biolink:NamedThing class discovery objective A class discovery objective (sometimes called unsupervised classification) is a data transformation objective where the aim is to organize input data (typically vectors of attributes) into classes, where the number of classes and their specifications are not known a priori. Depending on usage, the class assignment can be definite or probabilistic. RBO_relaxed.owl OBI:0200179 biolink:NamedThing class prediction objective A class prediction objective (sometimes called supervised classification) is a data transformation objective where the aim is to create a predictor from training data through a machine learning technique. The training data consist of pairs of objects (typically vectors of attributes) and class labels for these objects. The resulting predictor can be used to attach class labels to any valid novel input object. Depending on usage, the prediction can be definite or probabilistic. A classification is learned from the training data and can then be tested on test data. RBO_relaxed.owl OBI:0000713 biolink:NamedThing GenePattern software a software that provides access to more than 100 tools for gene expression analysis, proteomics, SNP analysis and common data processing tasks. RBO_relaxed.owl OBI:0000727 biolink:NamedThing k-nearest neighbors A k-nearest neighbors is a data transformation which achieves a class discovery or partitioning objective, in which an input data object with vector y is assigned to a class label based upon the k closest training data set points to y; where k is the largest value that class label is assigned. RBO_relaxed.owl OBI:0200041 biolink:NamedThing k-means clustering A k-means clustering is a data transformation which achieves a class discovery or partitioning objective, which takes as input a collection of objects (represented as points in multidimensional space) and which partitions them into a specified number k of clusters. The algorithm attempts to find the centers of natural clusters in the data. The most common form of the algorithm starts by partitioning the input points into k initial sets, either at random or using some heuristic data. It then calculates the mean point, or centroid, of each set. It constructs a new partition by associating each point with the closest centroid. Then the centroids are recalculated for the new clusters, and the algorithm repeated by alternate applications of these two steps until convergence, which is obtained when the points no longer switch clusters (or alternatively centroids are no longer changed). RBO_relaxed.owl OBI:0200042 biolink:NamedThing hierarchical clustering A hierarchical clustering is a data transformation which achieves a class discovery objective, which takes as input data item and builds a hierarchy of clusters. The traditional representation of this hierarchy is a tree (visualized by a dendrogram), with the individual input objects at one end (leaves) and a single cluster containing every object at the other (root). RBO_relaxed.owl OBI:0200050 biolink:NamedThing dimensionality reduction A dimensionality reduction is data partitioning which transforms each input m-dimensional vector (x_1, x_2, ..., x_m) into an output n-dimensional vector (y_1, y_2, ..., y_n), where n is smaller than m. RBO_relaxed.owl OBI:0000792 biolink:NamedThing statistical model validation A data transformation which assesses how the results of a statistical analysis will generalize to an independent data set. RBO_relaxed.owl OBI:0000749 biolink:NamedThing CART A CART (classification and regression trees) is a data transformation method for producing a classification or regression model with a tree-based structure. RBO_relaxed.owl OBI:0000953 biolink:NamedThing processed specimen A specimen that has been intentionally physically modified. RBO_relaxed.owl OBI:0001000 biolink:NamedThing questionnaire A document with a set of printed or written questions with a choice of answers, devised for the purposes of a survey or statistical study. RBO_relaxed.owl OBI:0001930 biolink:NamedThing categorical value specification A value specification that is specifies one category out of a fixed number of nominal categories RBO_relaxed.owl OBI:0001931 biolink:NamedThing scalar value specification A value specification that consists of two parts: a numeral and a unit label RBO_relaxed.owl OBI:0002205 biolink:NamedThing histologic grade according to AJCC 7th edition A categorical value specification that is a histologic grade assigned to a tumor slide specimen according to the American Joint Committee on Cancer (AJCC) 7th Edition grading system. RBO_relaxed.owl OBI:0002210 biolink:NamedThing histologic grade according to the Fuhrman Nuclear Grading System A categorical value specification that is a histologic grade assigned to a tumor slide specimen according to the Fuhrman Nuclear Grading System. RBO_relaxed.owl OBI:0002215 biolink:NamedThing histologic grade for ovarian tumor A categorical value specification that is a histologic grade assigned to a ovarian tumor. RBO_relaxed.owl OBI:0002224 biolink:NamedThing pathologic primary tumor stage for colon and rectum according to AJCC 7th edition A categorical value specification that is a pathologic finding about one or more characteristics of colorectal cancer following the rules of the TNM American Joint Committee on Cancer (AJCC) version 7 classification system as they pertain to staging of the primary tumor. TNM pathologic primary tumor findings are based on clinical findings supplemented by histopathologic examination of one or more tissue specimens acquired during surgery. RBO_relaxed.owl OBI:0002232 biolink:NamedThing pathologic primary tumor stage for lung according to AJCC 7th edition A categorical value specification that is a pathologic finding about one or more characteristics of lung cancer following the rules of the TNM American Joint Committee on Cancer (AJCC) version 7 classification system as they pertain to staging of the primary tumor. TNM pathologic primary tumor findings are based on clinical findings supplemented by histopathologic examination of one or more tissue specimens acquired during surgery. RBO_relaxed.owl OBI:0002243 biolink:NamedThing pathologic primary tumor stage for kidney according to AJCC 7th edition A categorical value specification that is a pathologic finding about one or more characteristics of renal cancer following the rules of the TNM AJCC v7 classification system as they pertain to staging of the primary tumor. TNM pathologic primary tumor findings are based on clinical findings supplemented by histopathologic examination of one or more tissue specimens acquired during surgery. RBO_relaxed.owl OBI:0002256 biolink:NamedThing pathologic primary tumor stage for ovary according to AJCC 7th edition A categorical value specification that is a pathologic finding about one or more characteristics of ovarian cancer following the rules of the TNM AJCC v7 classification system as they pertain to staging of the primary tumor. TNM pathologic primary tumor findings are based on clinical findings supplemented by histopathologic examination of one or more tissue specimens acquired during surgery. RBO_relaxed.owl OBI:0002270 biolink:NamedThing pathologic lymph node stage for colon and rectum according to AJCC 7th edition A categorical value specification that is a pathologic finding about one or more characteristics of colorectal cancer following the rules of the TNM AJCC v7 classification system as they pertain to staging of regional lymph nodes. RBO_relaxed.owl OBI:0002279 biolink:NamedThing pathologic lymph node stage for lung according to AJCC 7th edition A categorical value specification that is a pathologic finding about one or more characteristics of lung cancer following the rules of the TNM AJCC v7 classification system as they pertain to staging of regional lymph nodes. RBO_relaxed.owl OBI:0002284 biolink:NamedThing pathologic lymph node stage for kidney according to AJCC 7th edition A categorical value specification that is a pathologic finding about one or more characteristics of renal cancer following the rules of the TNM AJCC v7 classification system as they pertain to staging of regional lymph nodes. RBO_relaxed.owl OBI:0002287 biolink:NamedThing pathologic lymph node stage for ovary according to AJCC 7th edition A categorical value specification that is a pathologic finding about one or more characteristics of ovarian cancer following the rules of the TNM AJCC v7 classification system as they pertain to staging of regional lymph nodes. RBO_relaxed.owl OBI:0002290 biolink:NamedThing pathologic distant metastases stage for colon according to AJCC 7th edition A categorical value specification that is a pathologic finding about one or more characteristics of colon cancer following the rules of the TNM AJCC v7 classification system as they pertain to distant metastases. TNM pathologic distant metastasis findings are based on clinical findings supplemented by histopathologic examination of one or more tissue specimens acquired during surgery. RBO_relaxed.owl OBI:0002298 biolink:NamedThing pathologic distant metastases stage for lung according to AJCC 7th edition A categorical value specification that is a pathologic finding about one or more characteristics of lung cancer following the rules of the TNM AJCC v7 classification system as they pertain to distant metastases. TNM pathologic distant metastasis findings are based on clinical findings supplemented by histopathologic examination of one or more tissue specimens acquired during surgery. RBO_relaxed.owl OBI:0002306 biolink:NamedThing pathologic distant metastases stage for kidney according to AJCC 7th edition A categorical value specification that is a pathologic finding about one or more characteristics of renal cancer following the rules of the TNM AJCC v7 classification system as they pertain to distant metastases. TNM pathologic distant metastasis findings are based on clinical findings supplemented by histopathologic examination of one or more tissue specimens acquired during surgery. RBO_relaxed.owl OBI:0002310 biolink:NamedThing pathologic distant metastases stage for ovary according to AJCC 7th edition A categorical value specification that is a pathologic finding about one or more characteristics of ovarian cancer following the rules of the TNM AJCC v7 classification system as they pertain to distant metastases. TNM pathologic distant metastasis findings are based on clinical findings supplemented by histopathologic examination of one or more tissue specimens acquired during surgery. RBO_relaxed.owl OBI:0002314 biolink:NamedThing clinical tumor stage group according to AJCC 7th edition A categorical value specification that is an assessment of the stage of a cancer according to the American Joint Committee on Cancer (AJCC) v7 staging systems. RBO_relaxed.owl OBI:0002326 biolink:NamedThing International Federation of Gynecology and Obstetrics cervical cancer stage value specification A categorical value specification that is an assessment of the stage of a gynecologic cancer according to the International Federation of Gynecology and Obstetrics (FIGO) staging systems. RBO_relaxed.owl OBI:0002341 biolink:NamedThing International Federation of Gynecology and Obstetrics ovarian cancer stage value specification A categorical value specification that is a pathologic finding about one or more characteristics of ovarian cancer following the rules of the FIGO classification system. RBO_relaxed.owl OBI:0002356 biolink:NamedThing performance status value specification A categorical value specification that is an assessment of a participant's performance status (general well-being and activities of daily life). RBO_relaxed.owl OBI:0002216 biolink:NamedThing histologic grade for ovarian tumor according to a two-tier grading system A histologic grade for ovarian tumor that is from a two-tier histological classification of tumors. RBO_relaxed.owl OBI:0002219 biolink:NamedThing histologic grade for ovarian tumor according to the World Health Organization A histologic grade for ovarian tumor that is from a histological classification by the World Health Organization (WHO). RBO_relaxed.owl OBI:0002357 biolink:NamedThing Eastern Cooperative Oncology Group score value specification A performance status value specification designed by the Eastern Cooperative Oncology Group to assess disease progression and its affect on the daily living abilities of the patient. RBO_relaxed.owl OBI:0002363 biolink:NamedThing Karnofsky score vaue specification A performance status value specification designed for classifying patients 16 years of age or older by their functional impairment. RBO_relaxed.owl OBI:0002983 biolink:NamedThing altitude measurement datum A length measurement datum between a point at sea or ground level and some point above it. RBO_relaxed.owl OBI:0200033 biolink:NamedThing leave one out cross validation method is a data transformation : leave-one-out cross-validation (LOOCV) involves using a single observation from the original sample as the validation data, and the remaining observations as the training data. This is repeated such that each observation in the sample is used once as the validation data RBO_relaxed.owl OBI:0200051 biolink:NamedThing principal components analysis dimensionality reduction A principal components analysis dimensionality reduction is a dimensionality reduction achieved by applying principal components analysis and by keeping low-order principal components and excluding higher-order ones. RBO_relaxed.owl OBI:0200188 biolink:NamedThing cross validation objective A cross validation objective is a data transformation objective in which the aim is to partition a sample of data into subsets such that the analysis is initially performed on a single subset, while the other subset(s) are retained for subsequent use in confirming and validating the initial analysis. RBO_relaxed.owl OBI:0200190 biolink:NamedThing clustered data visualization A data visualization which has input of a clustered data set and produces an output of a report graph which is capable of rendering data of this type. RBO_relaxed.owl OBI:0400065 biolink:NamedThing light source A light source is an optical subsystem that provides light for use in a distant area using a delivery system (e.g., fiber optics). Light sources may include one of a variety of lamps (e.g., xenon, halogen, mercury). Most light sources are operated from line power, but some may be powered from batteries. They are mostly used in endoscopic, microscopic, and other examination and/or in surgical procedures. The light source is part of the optical subsystem. In a flow cytometer the light source directs high intensity light at particles at the interrogation point. The light source in a flow cytometer is usually a laser. RBO_relaxed.owl PATO:0000011 biolink:NamedThing age A time quality inhering in a bearer by virtue of how long the bearer has existed. RBO_relaxed.owl PATO:0000048 biolink:NamedThing hardness A physical quality inhering in a bearer by virtue of the bearer's resistance to pressure, being broken, or pierced RBO_relaxed.owl PATO:0001543 biolink:NamedThing flexibility A physical quality inhering in a bearer by virtue of the bearer's disposition to being turned, bowed, or twisted without breaking. RBO_relaxed.owl PATO:0001736 biolink:NamedThing solid configuration A physical quality inhering in a bearer by virtue of the bearer's parts having the arrangement which exhibits characteristics of solids. RBO_relaxed.owl PATO:0000052 biolink:NamedThing shape A morphological quality inhering in a bearer by virtue of the bearer's ratios of distances between its features (points, edges, surfaces and also holes etc). RBO_relaxed.owl PATO:0000117 biolink:NamedThing size A morphology quality inhering in a bearer by virtue of the bearer's physical magnitude. RBO_relaxed.owl PATO:0000122 biolink:NamedThing length A 1-D extent quality which is equal to the distance between two points. RBO_relaxed.owl PATO:0000136 biolink:NamedThing closure A morphological quality pertaining to the degree to which an object contains an opening, aperture, orifice or vent. RBO_relaxed.owl PATO:0000068 biolink:NamedThing qualitative RBO_relaxed.owl PATO:0002300 biolink:NamedThing increased quality A quality that has a value that is increased compared to normal or average. RBO_relaxed.owl PATO:0000069 biolink:NamedThing deviation (from_normal) A quality inhering in a bearer by virtue of the whether the bearer differs from normal or average. RBO_relaxed.owl PATO:0000461 biolink:NamedThing normal A quality inhering in a bearer by virtue of the bearer's exhibiting no deviation from normal or average. RBO_relaxed.owl PATO:0000169 biolink:NamedThing viability An organismal quality inhering in a bearer or a population by virtue of the bearer's disposition to survive and develop normally or the number of surviving individuals in a given population. RBO_relaxed.owl PATO:0000261 biolink:NamedThing maturity A quality of a single physical entity which is held by a bearer when the latter exhibits a state of growth, differentiation, or development. RBO_relaxed.owl PATO:0001729 biolink:NamedThing shedability An organismal quality inhering in a bearer by virtue of the bearer's disposition to lose an entity by natural process. RBO_relaxed.owl PATO:0001992 biolink:NamedThing cellularity An organismal quality inhering in a bearer by virtue of the bearer's consisting cells. RBO_relaxed.owl PATO:0001475 biolink:NamedThing increased position A position which is relatively high. RBO_relaxed.owl PATO:0001563 biolink:NamedThing increased mass A mass which is higher than normal or average. RBO_relaxed.owl PATO:0001580 biolink:NamedThing increased contractility A contractility which is relatively high. RBO_relaxed.owl PATO:0001693 biolink:NamedThing increased viscosity A viscosity which relatively high. RBO_relaxed.owl PATO:0002287 biolink:NamedThing increased elasticity An elasticity which is relatively high. RBO_relaxed.owl PATO:0000389 biolink:NamedThing acute A quality of a process inhering in a bearer by virtue of the bearer's having a sudden onset, sharp rise, and short course. RBO_relaxed.owl PATO:0000498 biolink:NamedThing increased duration A duration quality of a process which is relatively high. RBO_relaxed.owl PATO:0001863 biolink:NamedThing chronic A duration quality of a process inhering in a bearer by virtue of the bearer's having slow progressive course of indefinite duration. RBO_relaxed.owl PATO:0000402 biolink:NamedThing branched A branchiness quality inhering in a bearer by virtue of the bearer's having branches. RBO_relaxed.owl PATO:0002009 biolink:NamedThing branchiness A shape quality inhering in a bearer by virtue of the degree to which there are subdivisions or offshoots in a bearer entity. RBO_relaxed.owl PATO:0000407 biolink:NamedThing flat A quality inhering in a bearer by virtue of the bearer's having a horizontal surface without a slope, tilt, or curvature. RBO_relaxed.owl PATO:0000411 biolink:NamedThing circular A shape quality inhering in a bearer by virtue of the bearer's being such that every part of the surface or the circumference is equidistant from the center. RBO_relaxed.owl PATO:0000947 biolink:NamedThing elliptic A spheroid quality inhering in a bearer by virtue of the bearer's being oval with two axes of symmetry, as produced by a conical section. RBO_relaxed.owl PATO:0001476 biolink:NamedThing decreased position A positional which is relatively low. RBO_relaxed.owl PATO:0000608 biolink:NamedThing closed A morphological quality inhering in a bearer by virtue of the bearer's affording blocked passage or view. RBO_relaxed.owl PATO:0002318 biolink:NamedThing superelliptic A shape constituting a transition between a rectangle and a circle; a closed curve, of which the circle and ellipse are special cases, whose parametric equation is x = a.cos2/rt, y = b.cos2/rt RBO_relaxed.owl PATO:0000957 biolink:NamedThing opacity An optical quality which obtains by virtue of the ability of the bearer to absorb visible light. RBO_relaxed.owl PATO:0001300 biolink:NamedThing optical quality An EM radiation quality in which the EM radiation is within the fiat range of the spectrum visible deemed to be light. RBO_relaxed.owl PATO:0000964 biolink:NamedThing transparent A optical quality inhering in a bearer by virtue of the bearer's lacking opacity. RBO_relaxed.owl PATO:0000992 biolink:NamedThing viscosity A physical quality of a fluid inhering in a bearer by virtue of the bearer's disposition to internal resistance to flow. RBO_relaxed.owl PATO:0001735 biolink:NamedThing liquid configuration A physical quality inhering in a bearer by virtue of the bearer's parts having the arrangement which exhibits characteristics of liquids. RBO_relaxed.owl PATO:0000998 biolink:NamedThing viscous A viscosity quality inhering in a bearer by virtue of the bearer's having viscosity. RBO_relaxed.owl PATO:0001591 biolink:NamedThing curvature A surface shape quality inhering in a bearer by virtue of the bearer's exhibiting a degree of bending. RBO_relaxed.owl PATO:0002005 biolink:NamedThing concavity Surface shape that refers to the inward or outward curvature of the surface. RBO_relaxed.owl PATO:0002006 biolink:NamedThing 2-D shape A shape that inheres in a 2 dimensional entity, such as a cross section or projection of a 3 dimensional entity. RBO_relaxed.owl PATO:0002266 biolink:NamedThing 3-D shape A shape that inheres in a 3 dimensional entity. RBO_relaxed.owl PATO:0001171 biolink:NamedThing elastic An elasticity quality inhering in a bearer by virtue of the bearer's ability to recover its size and shape after deformation in any way. RBO_relaxed.owl PATO:0001185 biolink:NamedThing larval A maturity quality inhering in a bearer by virtue of the bearer's indirect development, undergoing metamorphosis. RBO_relaxed.owl PATO:0001291 biolink:NamedThing electromagnetic (EM) radiation quality A physical quality that inheres in an bearer by virtue of how that bearer interacts with electromagnetic radiation. RBO_relaxed.owl PATO:0070060 biolink:NamedThing quality of interaction of a substance with electromagnetic radiation A quality of a substance on which or through which electromagnetic radiation impinges or traverses with respect to radiation. This substance quality changes the quality of the incident radiation with respect to any of: intensity, direction, scatter and wavelength. RBO_relaxed.owl PATO:0001374 biolink:NamedThing ploidy A cellular quality inhering in a bearer by virtue of the bearer's number of homologous sets of chromosomes in the nucleus or primary chromosome-containing compartment of the cell, each set essentially coding for all the biological traits of the organism. RBO_relaxed.owl PATO:0001396 biolink:NamedThing cellular quality A monadic quality of continuant that exists at the cellular level of organisation. RBO_relaxed.owl PATO:0001397 biolink:NamedThing cellular potency A cellular quality that arises by virtue of whether the bearer's disposition to differentiate into one or more mature cell types. RBO_relaxed.owl PATO:0001404 biolink:NamedThing nucleate quality A cellular quality inhering in a bearer by virtue of bearer's number of nuclei. RBO_relaxed.owl PATO:0001408 biolink:NamedThing ciliatedness A cellular quality inhering in a bearer by virtue of the bearer's having thin, tail-like projections extending outwards from the cell body. RBO_relaxed.owl PATO:0070045 biolink:NamedThing anatomical histological quality A quality inhering in an anotomical structure by virtue of its capacity to be stained by specific histological dyes. RBO_relaxed.owl PATO:0001687 biolink:NamedThing elevation A positional quality inhering in a bearer by virtue of the bearer's vertical distance of a point above or below a reference surface. RBO_relaxed.owl PATO:0002181 biolink:NamedThing displaced A positional quality inhering in a bearer by virtue the bearer's being changed in position. RBO_relaxed.owl PATO:0001744 biolink:NamedThing irradiated A quality of a substance inhering in a bearer by virtue of it being currently or previously exposed to electromagnetic radiation, RBO_relaxed.owl PATO:0001690 biolink:NamedThing contractile A contractility quality inhering in a bearer by virtue of the bearer's ability of contracting or being contracted. RBO_relaxed.owl PATO:0001748 biolink:NamedThing invaginated A shape quality in which a portion of the outermost boundary of an entity folds in space such that a portion that was originally convex is now concave. RBO_relaxed.owl PATO:0001857 biolink:NamedThing concave A shape quality in a bearer by virtue of the bearer's curving inward. RBO_relaxed.owl PATO:0001873 biolink:NamedThing cylindrical A convex 3-D shape quality inhering in a bearer by virtue of the bearer's exhibiting a consistently-sized round cross section. RBO_relaxed.owl PATO:0002007 biolink:NamedThing convex 3-D shape A complete three dimensional shape in which for every line connecting pair of points on the object is within the object. Or: a shape lacking cavities. Contrast: concave. RBO_relaxed.owl PATO:0001987 biolink:NamedThing saccular A structural quality inhering in a bearer by virtue of the bearer's having a three dimensional cavity with a narrow or no opening, and often containing an anatomical substance. RBO_relaxed.owl PATO:0002078 biolink:NamedThing hollow A quality inhering in a bearer by virtue of the bearer's having an empty space or cavity within. RBO_relaxed.owl PATO:0001993 biolink:NamedThing multicellular A cellularity quality inhering in a bearer by virtue of the bearer's consisting of more than one cell. RBO_relaxed.owl PATO:0002045 biolink:NamedThing dendritic A branched quality inhering in a bearer by virtue of the bearer's having smaller branches arising from larger branches. Resembling a tree in branching structure. RBO_relaxed.owl PATO:0002226 biolink:NamedThing subcylindrical A cylindrical shape quality inhering in a bearer by virtue of the bearer's being imperfectly cylindrical or approximately cylindrical. RBO_relaxed.owl PATO:0002299 biolink:NamedThing tubular A cylindrical shape that is hollow. RBO_relaxed.owl PATO:0002301 biolink:NamedThing decreased quality A quality that has a value that is decreased compared to normal or average. RBO_relaxed.owl PATO:0002309 biolink:NamedThing fiber shaped A convex 3-D shape quality inhering in a bearer by virtue of the bearer's exhibiting a by virtue of the bearer's exhibiting a consistently sized and approximately round cross-section along its length, which is many times larger than its diameter. RBO_relaxed.owl PATO:0002468 biolink:NamedThing distensible A structure quality inhering in a bearer by virtue of the bearer's being capable of swelling or stretching. RBO_relaxed.owl PCO:0000001 biolink:NamedThing population of organisms A collection of organisms, all of the same species, that live in the same place. RBO_relaxed.owl PCO:0000018 biolink:NamedThing single-species collection of organisms A material entity that has as parts two or more organisms, viruses, or viroids of the same species and no members of any other species. RBO_relaxed.owl PCO:0000002 biolink:NamedThing ecological community A multi-species collection of organisms of at least two different species, living in a particular area. Must have at least two populations of different species as members. RBO_relaxed.owl PCO:0000029 biolink:NamedThing multi-species collection of organisms A collection of organisms that consists of two or more organisms from at least two species. RBO_relaxed.owl PCO:0001000 biolink:NamedThing pair of interacting organisms A collection of organisms that consists of exactly two organism, viruses, or viroids that are interacting with each other. RBO_relaxed.owl PO:0009011 biolink:NamedThing plant structure A plant anatomical entity (PO:0025131) that is, or was, part of a plant, or was derived from a part of a plant. RBO_relaxed.owl PO:0009002 biolink:NamedThing plant cell A cell which is a plant structure (PO:0009011). RBO_relaxed.owl PO:0009007 biolink:NamedThing portion of plant tissue A plant structure (PO:0009011) that consists predominantly of similarly specialized plant cells (PO:0009002) of one or more types. RBO_relaxed.owl PO:0025496 biolink:NamedThing multi-tissue plant structure A plant structure (PO:0009011) that has as parts two or more portions of plant tissue (PO:0009007) of at least two different types and which through specific morphogenetic processes forms a single structural unit demarcated by primarily bona-fide boundaries from other structural units of different types. RBO_relaxed.owl PO:0025497 biolink:NamedThing collective plant structure A plant structure (PO:0009011) that is a proper part of a whole plant (PO:0000003) and includes two or more adjacent plant organs (PO:0009008) or adjacent cardinal organ parts (PO:0025001), along with any associated portions of plant tissue (PO:0009007). RBO_relaxed.owl PO:0000037 biolink:NamedThing shoot axis apex A shoot axis (PO:0025029) that is the most distal part of a shoot system (PO:0009006) and has as parts a shoot apical meristem (PO:0020148) and the youngest primordia (PO:0025127). RBO_relaxed.owl PO:0025029 biolink:NamedThing shoot axis A plant axis (PO:0025004) that is part of a shoot system (PO:0009006). RBO_relaxed.owl PO:0000225 biolink:NamedThing peripheral zone A portion of meristem tissue (PO:0009013) which is the organogenic region of the meristem, characterized by higher rates of cell division. RBO_relaxed.owl PO:0009013 biolink:NamedThing portion of meristem tissue A portion of plant tissue (PO:0009007) in which plant cells (PO:0009002) have retained their embryonic characteristics, or have reverted to them secondarily, and that divide to produce new cells that can undergo differentiation to form mature tissues, i.e. they have a capacity for morphogenesis and growth. RBO_relaxed.owl PO:0006079 biolink:NamedThing shoot system meristem A portion of meristem tissue (PO:0009013) that is part of a shoot system (PO:0009006). RBO_relaxed.owl PO:0006210 biolink:NamedThing protoderm A portion of meristem tissue (PO:0009013) that is the outer layer of an apical meristem (PO:0020144), or the outer layer of a plant embryo proper (PO:0000001), and gives rise to a portion of epidermis (PO:0005679). RBO_relaxed.owl PO:0020144 biolink:NamedThing apical meristem A maximal portion of meristem tissue (PO:0009013) located at a shoot apex (PO:0000037) or root tip (PO:0000025). RBO_relaxed.owl PO:0025127 biolink:NamedThing primordium A portion of meristem tissue (PO:0009013) that has as parts protoderm (PO:0006210) and sub-epidermal meristematic tissue and is committed to the development of a particular plant structure (PO:0009011). RBO_relaxed.owl PO:0025430 biolink:NamedThing phyllome anlagen A portion of meristem tissue (PO:0009013) that is part of a peripheral zone (PO:0000225) of a shoot apical meristem (PO:0020148) and will give rise to a phyllome primordium (PO:0025128). RBO_relaxed.owl PO:0025433 biolink:NamedThing root anlagen A portion of meristem tissue (PO:0009013) that is committed to the development of a root primordium (PO:0005029). RBO_relaxed.owl PO:0004010 biolink:NamedThing meristematic cell A native plant cell (PO:0025606) synthesizing protoplasm and producing new cells by division and with only a primary cell wall. RBO_relaxed.owl PO:0025606 biolink:NamedThing native plant cell A plant cell (PO:0009002) that is either part of a multicellular whole plant (PO:0000003) 'in vivo' or a unicellular organism 'in natura' (i.e. part of a natural environment). RBO_relaxed.owl PO:0009008 biolink:NamedThing plant organ A multi-tissue plant structure (PO:0025496) that is a functional unit, is a proper part of a whole plant (PO:0000003), and includes portions of plant tissue (PO:0009007) of at least two different types that derive from a common developmental path. RBO_relaxed.owl PO:0025004 biolink:NamedThing plant axis An axial plant organ (PO:0009008). RBO_relaxed.owl PO:0007033 biolink:NamedThing whole plant development stage A plant structure development stage (PO:0009012) that has as primary participant a whole plant (PO:0000003). RBO_relaxed.owl PO:0009012 biolink:NamedThing plant structure development stage A stage in the life of a plant structure (PO:0009011) during which the plant structure undergoes developmental processes. RBO_relaxed.owl PO:0009006 biolink:NamedThing shoot system A collective plant organ structure (PO:0025007) that produces shoot-borne portions of meristem tissue (PO:0009013) and the plant structures (PO:0009011) that arise from them. RBO_relaxed.owl PO:0025007 biolink:NamedThing collective plant organ structure A collective plant structure (PO:0025497) that is a proper part of a whole plant (PO:0000003), and is composed of two or more adjacent plant organs (PO:0009008) and the associated portions of plant tissue (PO:0009007). RBO_relaxed.owl PO:0025025 biolink:NamedThing root system A collective plant organ structure (PO:0025007) that produces root meristems (PO:0006085), the plant structures (PO:0009011) that arise from them and the parts thereof. RBO_relaxed.owl PO:0020148 biolink:NamedThing shoot apical meristem A shoot system meristem (PO:0006079) formed at the apex of the shoot axis (PO:0025029), including those originating from an axillary bud meristem (PO:0000232). RBO_relaxed.owl PO:0025337 biolink:NamedThing life of whole plant stage A maximal whole plant development stage. RBO_relaxed.owl PO:0028002 biolink:NamedThing sporophyte development stage A whole plant development stage (PO:0007033) that has as primary participant a whole plant (PO:0000003) during the interval between fertilization (or apogamy) and death. RBO_relaxed.owl PR:000001005 biolink:NamedThing integrin alpha with A domain An integrin alpha that contains an A domain. A hallmark of this class is the presence of a von Willebrand factor type A domain (Pfam:PF00092) (I-domain) of approximately 200 amino acid residues at the N terminus, which confers divalent cation binding properties. Unlike other integrin alpha proteins, they do not undergo proteolytic cleavage. RBO_relaxed.owl PR:000001023 biolink:NamedThing neural cell adhesion molecule NCAM A neural cell adhesion molecule that is involved in neuronal development, synaptic plasticity, and regeneration. RBO_relaxed.owl PR:P01731 biolink:NamedThing T-cell surface glycoprotein CD8 alpha chain (mouse) A T-cell surface glycoprotein CD8 alpha chain that is encoded in the genome of mouse. RBO_relaxed.owl PR:P05555 biolink:NamedThing integrin alpha-M (mouse) An integrin alpha-M that is encoded in the genome of mouse. RBO_relaxed.owl PR:P06332 biolink:NamedThing T-cell surface glycoprotein CD4 (mouse) A CD4 molecule that is encoded in the genome of mouse. RBO_relaxed.owl PR:P08920 biolink:NamedThing T-cell surface antigen CD2 (mouse) A CD2 molecule that is encoded in the genome of mouse. RBO_relaxed.owl PR:P10810 biolink:NamedThing monocyte differentiation antigen CD14 (mouse) A CD14 molecule that is encoded in the genome of mouse. RBO_relaxed.owl PR:P13379 biolink:NamedThing T-cell surface glycoprotein CD5 (mouse) A T-cell surface glycoprotein CD5 that is encoded in the genome of mouse. RBO_relaxed.owl PR:P13595 biolink:NamedThing neural cell adhesion molecule 1 (mouse) A neural cell adhesion molecule 1 that is encoded in the genome of mouse. RBO_relaxed.owl PR:P16872 biolink:NamedThing interleukin-7 receptor subunit alpha (mouse) An interleukin-7 receptor subunit alpha that is encoded in the genome of mouse. RBO_relaxed.owl PR:P19437 biolink:NamedThing B-lymphocyte antigen CD20 (mouse) A membrane-spanning 4-domains subfamily A member 1 that is encoded in the genome of mouse. RBO_relaxed.owl PR:P22091 biolink:NamedThing T-cell acute lymphocytic leukemia protein 1 homolog (mouse) A T-cell acute lymphocytic leukemia protein 1 that is encoded in the genome of mouse. RBO_relaxed.owl PR:P22646 biolink:NamedThing T-cell surface glycoprotein CD3 epsilon chain (mouse) A CD3 epsilon that is encoded in the genome of mouse. RBO_relaxed.owl PR:P25918 biolink:NamedThing B-lymphocyte antigen CD19 (mouse) A CD19 molecule that is encoded in the genome of mouse. RBO_relaxed.owl PR:P35461 biolink:NamedThing lymphocyte antigen 6G (mouse) A lymphocyte antigen 6G that is encoded in the genome of mouse. RBO_relaxed.owl PR:P35918 biolink:NamedThing vascular endothelial growth factor receptor 2 (mouse) A vascular endothelial growth factor receptor 2 that is encoded in the genome of mouse. RBO_relaxed.owl PR:P37237 biolink:NamedThing fibroblast growth factor 8 (mouse) A fibroblast growth factor 8 that is encoded in the genome of mouse. RBO_relaxed.owl PR:P55284 biolink:NamedThing cadherin-5 (mouse) A cadherin-5 that is encoded in the genome of mouse. RBO_relaxed.owl PR:Q62226 biolink:NamedThing sonic hedgehog protein (mouse) A sonic hedgehog protein that is encoded in the genome of mouse. RBO_relaxed.owl PR:Q62351 biolink:NamedThing transferrin receptor protein 1 (mouse) A transferrin receptor protein 1 that is encoded in the genome of mouse. RBO_relaxed.owl PR:Q64314 biolink:NamedThing hematopoietic progenitor cell antigen CD34 (mouse) A CD34 molecule that is encoded in the genome of mouse. RBO_relaxed.owl PR:P01308 biolink:NamedThing insulin gene translation product (human) An insulin gene translation product that is encoded in the genome of human. RBO_relaxed.owl PR:P01730 biolink:NamedThing T-cell surface glycoprotein CD4 (human) A CD4 molecule that is encoded in the genome of human. RBO_relaxed.owl PR:P01732 biolink:NamedThing T-cell surface glycoprotein CD8 alpha chain (human) A T-cell surface glycoprotein CD8 alpha chain that is encoded in the genome of human. RBO_relaxed.owl PR:P02786 biolink:NamedThing transferrin receptor protein 1 (human) A transferrin receptor protein 1 that is encoded in the genome of human. RBO_relaxed.owl PR:P06127 biolink:NamedThing T-cell surface glycoprotein CD5 (human) A T-cell surface glycoprotein CD5 that is encoded in the genome of human. RBO_relaxed.owl PR:P06729 biolink:NamedThing T-cell surface antigen CD2 (human) A CD2 molecule that is encoded in the genome of human. RBO_relaxed.owl PR:P07766 biolink:NamedThing T-cell surface glycoprotein CD3 epsilon chain (human) A CD3 epsilon that is encoded in the genome of human. RBO_relaxed.owl PR:P08571 biolink:NamedThing monocyte differentiation antigen CD14 (human) A CD14 molecule that is encoded in the genome of human. RBO_relaxed.owl PR:P11215 biolink:NamedThing integrin alpha-M (human) An integrin alpha-M that is encoded in the genome of human. RBO_relaxed.owl PR:P11836 biolink:NamedThing B-lymphocyte antigen CD20 (human) A membrane-spanning 4-domains subfamily A member 1 that is encoded in the genome of human. RBO_relaxed.owl PR:P13591 biolink:NamedThing neural cell adhesion molecule 1 (human) A neural cell adhesion molecule 1 that is encoded in the genome of human. RBO_relaxed.owl PR:P15391 biolink:NamedThing B-lymphocyte antigen CD19 (human) A CD19 molecule that is encoded in the genome of human. RBO_relaxed.owl PR:P16871 biolink:NamedThing interleukin-7 receptor subunit alpha (human) An interleukin-7 receptor subunit alpha that is encoded in the genome of human. RBO_relaxed.owl PR:P17542 biolink:NamedThing T-cell acute lymphocytic leukemia protein 1 (human) A T-cell acute lymphocytic leukemia protein 1 that is encoded in the genome of human. RBO_relaxed.owl PR:P28906 biolink:NamedThing hematopoietic progenitor cell antigen CD34 (human) A CD34 molecule that is encoded in the genome of human. RBO_relaxed.owl PR:P33151 biolink:NamedThing cadherin-5 (human) A cadherin-5 that is encoded in the genome of human. RBO_relaxed.owl PR:P35968 biolink:NamedThing vascular endothelial growth factor receptor 2 (human) A vascular endothelial growth factor receptor 2 that is encoded in the genome of human. RBO_relaxed.owl PR:P55075 biolink:NamedThing fibroblast growth factor 8 (human) A fibroblast growth factor 8 that is encoded in the genome of human. RBO_relaxed.owl PR:Q15465 biolink:NamedThing sonic hedgehog protein (human) A sonic hedgehog protein that is encoded in the genome of human. RBO_relaxed.owl OBO:RBO_00000001 biolink:NamedThing ionizing radiation categorized by source Ionizing radiation classified by the material entity which generates or emits it. RBO_relaxed.owl OBO:RBO_00000112 biolink:NamedThing high linear energy transfer radiation Neutrons or charged particles, such as protons or alpha particles that produce ionizing events densely spaced on a molecular scale (e.g., >10 keV-micron^[-1]. RBO_relaxed.owl OBO:RBO_00000113 biolink:NamedThing low linear energy transfer radiation X and gamma rays or light charged particles such as electrons that produce sparse ionizing events far apart on a molecular scale. RBO_relaxed.owl OBO:RBO_00000114 biolink:NamedThing ionizing electromagnetic radiation Electromagnetic radiation having sufficient energy to remove one or more electrons from an atom RBO_relaxed.owl OBO:RBO_00005012 biolink:NamedThing ionizing radiation energy The kinetic energy carried by a particle or photon of ionizing radiation. RBO_relaxed.owl OBO:RBO_00000002 biolink:NamedThing space radiation Radiation originating outside the Earth's atmosphere. RBO_relaxed.owl OBO:RBO_00000003 biolink:NamedThing ground radiation Radiation produced on Earth or on another planetary body by natural or artificial means. RBO_relaxed.owl OBO:RBO_00000005 biolink:NamedThing Fe-56 ion radiation Atomic nuclei, each with 26 protons and 30 neutrons with kinetic energy imparted by natural or artificial means such as by a particle accelerator RBO_relaxed.owl OBO:RBO_00005001 biolink:NamedThing heavy ion radiation Atomic nuclei, with atomic number 2 or greater and kinetic energy imparted by natural or artificial means RBO_relaxed.owl OBO:RBO_00000006 biolink:NamedThing C-12 ion radiation Atomic nuclei, each with 6 protons and 6 neutrons with kinetic energy imparted by natural or artificial means such as by a particle accelerator RBO_relaxed.owl OBO:RBO_00000007 biolink:NamedThing Si-28 ion radiation Atomic nuclei, each with 14 protons and 14 neutrons with kinetic energy imparted by natural or artificial means such as by a particle accelerator RBO_relaxed.owl OBO:RBO_00000008 biolink:NamedThing He-4 ion radiation Atomic nuclei, each with 2 protons and 2 neutrons with kinetic energy imparted by natural or artificial means such as by a particle accelerator RBO_relaxed.owl OBO:RBO_00000009 biolink:NamedThing Ne-20 ion radiation Atomic nuclei, each with 10 protons and 10 neutrons with kinetic energy imparted by natural or artificial means such as by a particle accelerator RBO_relaxed.owl OBO:RBO_00000125 biolink:NamedThing O-16 ion radiation Atomic nuclei, each with 8 protons and 8 neutrons with kinetic energy imparted by natural or artificial means such as by a particle accelerator RBO_relaxed.owl OBO:RBO_00000126 biolink:NamedThing Ar-40 ion radiation Atomic nuclei, each with 18 protons and 22 neutrons with kinetic energy imparted by natural or artificial means such as by a particle accelerator RBO_relaxed.owl OBO:RBO_00000127 biolink:NamedThing Ti-48 ion radiation Atomic nuclei, each with 22 protons and 26 neutrons with kinetic energy imparted by natural or artificial means such as by a particle accelerator RBO_relaxed.owl OBO:RBO_00000128 biolink:NamedThing Kr-84 ion radiation Atomic nuclei, each with 36 protons and 48 neutrons with kinetic energy imparted by natural or artificial means such as by a particle accelerator RBO_relaxed.owl OBO:RBO_00000129 biolink:NamedThing Nb-93 ion radiation Atomic nuclei, each with 41 protons and 52 neutrons with kinetic energy imparted by natural or artificial means such as by a particle accelerator RBO_relaxed.owl OBO:RBO_00000130 biolink:NamedThing Ag-107 ion radiation Atomic nuclei, each with 47 protons and 60 neutrons with kinetic energy imparted by natural or artificial means such as by a particle accelerator RBO_relaxed.owl OBO:RBO_00000131 biolink:NamedThing Xe-129 ion radiation Atomic nuclei, each with 54 protons and 75 neutrons with kinetic energy imparted by natural or artificial means such as by a particle accelerator RBO_relaxed.owl OBO:RBO_00000132 biolink:NamedThing Ta-181 ion radiation Atomic nuclei, each with 73 protons and 108 neutrons with kinetic energy imparted by natural or artificial means such as by a particle accelerator RBO_relaxed.owl OBO:RBO_00000133 biolink:NamedThing Au-197 ion radiation Atomic nuclei, each with 79 protons and 118 neutrons with kinetic energy imparted by natural or artificial means such as by a particle accelerator RBO_relaxed.owl OBO:RBO_00000134 biolink:NamedThing N-14 ion radiation Atomic nuclei, each with 7 protons and 7 neutrons with kinetic energy imparted by natural or artificial means such as by a particle accelerator RBO_relaxed.owl OBO:RBO_00000011 biolink:NamedThing active dosimeter A radiation measuring device which records dose at the time of detection, with data available in real time RBO_relaxed.owl OBO:RBO_00000012 biolink:NamedThing passive dosimeter A radiation measuring device which integrates the amount of radiation to which it is exposed. Passive detectors are interrogated at a later time to determine the dose. RBO_relaxed.owl OBO:RBO_00000013 biolink:NamedThing background ionizing radiation The amount of ionizing radiation to which a member of the population on Earth is exposed from natural sources, such as terrestrial radiation from naturally-occurring radionuclides in the soil, cosmic radiation originating in outer space, and naturally-occurring ra RBO_relaxed.owl OBO:RBO_00000117 biolink:NamedThing charged particle radiation Charged particles with kinetic energy imparted by natural or artificial means (such as by a particle accelerator) RBO_relaxed.owl OBO:RBO_00015001 biolink:NamedThing neutral particle radiation Uncharged particles with kinetic energy imparted by natural or artificial means (such as by a particle accelerator) RBO_relaxed.owl OBO:RBO_00000014 biolink:NamedThing effective dose The sum of the equivalent doses to all organs in the body, each adjusted to account for the sensitivity of the organ to radiation. Effective dose is calculated for the whole body. Effective dose is expressed in millisieverts (mSv). RBO_relaxed.owl OBO:RBO_010016 biolink:NamedThing radiation dose A measurement datum of the quantity of radiation absorbed by a substance or organism. The term "radiation dose" may for example refer to absorbed dose, organ dose, dose equivalent or equivalent dose, depending upon context and weighting factor(s). RBO_relaxed.owl OBO:RBO_00000023 biolink:NamedThing equivalent dose The product of the mean absorbed dose in an organ or tissue and the radiation weighting factor (w_R )of the radiation type of interest RBO_relaxed.owl OBO:RBO_00000024 biolink:NamedThing dose fraction The absorbed radiation dose administered in a single one of a series comprising a fractionated radiation exposure RBO_relaxed.owl OBO:RBO_00005010 biolink:NamedThing absorbed radiation dose The amount of energy from any type of ionizing radiation deposited in a specified mass of any medium. RBO_relaxed.owl OBO:RBO_00015007 biolink:NamedThing nanodosimetric measurement datum Measurement of the pattern (frequency and spatial distribution) of ionization events produced by energy deposition in time and space in a substance characterized by linear dimensions of the order of 1-100 nanometers RBO_relaxed.owl OBO:RBO_00015008 biolink:NamedThing specific energy measurement datum In microdosimetry the specific energy, z, is the energy deposited by radiation ( in one or more deposition events) in a specified micrometric (or smaller) site divided my the mass of the site. Measured in Gy. RBO_relaxed.owl OBO:RBO_00015013 biolink:NamedThing microdosimetric measurement datum Measurement of the pattern (frequency and spatial distribution) of ionization events produced by energy deposition in time and space in a substance characterized by linear dimensions of the order of 1-100 micrometers. RBO_relaxed.owl OBO:RBO_010007 biolink:NamedThing dose equivalent The product of the absorbed dose (D) at a point and the quality factor (Q) at that point for the radiation type (i.e., H = DQ). The unit of H is J-kg^[-1] with the special name sievert (Sv) RBO_relaxed.owl OBO:RBO_010014 biolink:NamedThing organ dose The mean absorbed radiation dose in a specified tissue or organ of the human body. RBO_relaxed.owl OBO:RBO_00000015 biolink:NamedThing mixed radiation The process of exposing the same sample to more than one type and/or energy of radiation, in sequence or simultaneously. RBO_relaxed.owl OBO:RBO_00000049 biolink:NamedThing particle accelerator radiation Radiation produced by a particle accelerator. RBO_relaxed.owl OBO:RBO_00000017 biolink:NamedThing earth surface That part of the Earth exposed to the Earth atmosphere. RBO_relaxed.owl OBO:RBO_00000018 biolink:NamedThing earth atmosphere The region between the Earth's surface and an altitude of approximately 100 km RBO_relaxed.owl OBO:RBO_00005017 biolink:NamedThing cis-lunar space The region of space between the Earth and the Moon RBO_relaxed.owl OBO:RBO_00005018 biolink:NamedThing lunar orbit A region of space defined by a regular, repeating path of a specified object about Earth's moon RBO_relaxed.owl OBO:RBO_00005019 biolink:NamedThing lunar surface The area of the lunar landmass exposed to space RBO_relaxed.owl OBO:RBO_00005020 biolink:NamedThing cis-mars space The region of space between the Earth and Mars RBO_relaxed.owl OBO:RBO_00005021 biolink:NamedThing mars orbit A region of space defined by a regular, repeating path of a specified object about Mars RBO_relaxed.owl OBO:RBO_00005022 biolink:NamedThing mars surface The area of the Mars landmass exposed to the Martian atmosphere RBO_relaxed.owl OBO:RBO_00005023 biolink:NamedThing interplanetary space The region of space in the Solar System between planets RBO_relaxed.owl OBO:RBO_00005024 biolink:NamedThing planet surface The outermost solid or liquid area of a planet RBO_relaxed.owl OBO:RBO_00000019 biolink:NamedThing low earth orbit The region of outer space between the Earth's atmosphere and the innermost Earth radiation belt RBO_relaxed.owl OBO:RBO_00000020 biolink:NamedThing beyond low earth orbit That part of outer space beyond the Earth's radiation belts. RBO_relaxed.owl OBO:RBO_00000021 biolink:NamedThing fractionated radiation exposure A radiation dose administered in two or more exposures at specified time intervals RBO_relaxed.owl OBO:RBO_00002001 biolink:NamedThing accidental radiation exposure Unplanned exposure to radiation of any type in any environment or otherwise planned process. RBO_relaxed.owl OBO:RBO_00002004 biolink:NamedThing exposure to naturally ocurring radioactive material Exposure to naturally occurring radiation (NORM) of any type in any environment . RBO_relaxed.owl OBO:RBO_00002007 biolink:NamedThing anthropogenic radiation exposure Exposure to ionising radiation created by a man-made machine or exposure to a fixed source. For example a cobalt source, an X ray machine, an acceleratororf a nucler weapon. RBO_relaxed.owl OBO:RBO_00002119 biolink:NamedThing unplanned irradiation Irradiation that is not the result of a planned process RBO_relaxed.owl OBO:RBO_00015017 biolink:NamedThing internal radiation exposure Exposure to an inhaled, ingested, injected or implanted source of radiation of any origin as part of a planned or accidental process. RBO_relaxed.owl OBO:RBO_00015018 biolink:NamedThing external radiation exposure Exposure to an external source of radiation of any origin or type. RBO_relaxed.owl OBO:RBO_00015034 biolink:NamedThing multiple ion irradiation The process by an entity is exposed to two or more species of accelerated ions sequentially or simultaneously. RBO_relaxed.owl OBO:RBO_00000022 biolink:NamedThing millirad A unit of absorbed dose equal to 1/1000 of a rad RBO_relaxed.owl OBO:UO_1000135 biolink:NamedThing rad based unit RBO_relaxed.owl OBO:UO_0000135 biolink:NamedThing rad RBO_relaxed.owl OBO:RBO_00000026 biolink:NamedThing cosmic radiation Penetrating ionizing radiation, both particulate and electromagnetic, that originates in outer space RBO_relaxed.owl OBO:RBO_00000027 biolink:NamedThing galactic cosmic radiation Galactic cosmic radiation consists of high-energy charged particles originating from outside the solar system RBO_relaxed.owl OBO:RBO_00000028 biolink:NamedThing solar cosmic radiation Solar cosmic radiation is high-energy charged particles that originate from the sun. RBO_relaxed.owl OBO:RBO_00000044 biolink:NamedThing spacecraft module a self-contained unit of a spacecraft RBO_relaxed.owl OBO:RBO_00000046 biolink:NamedThing space station A spacecraft capable of supporting a human crew in orbit for an extended period of time. It lacks major propulsion or landing systems. Stations must have docking ports to allow other spacecraft to dock to transfer crew and supplies. RBO_relaxed.owl OBO:RBO_00000045 biolink:NamedThing international space station module A self-contained unit of the International Space Station. RBO_relaxed.owl OBO:RBO_00000047 biolink:NamedThing particle accelerator beamline The path leading from a particle accelerator to an experimental station used in experiments in particle physics, materials science, chemistry, and molecular biology, or in irradiation tests or to produce isotopes. RBO_relaxed.owl OBO:RBO_00005042 biolink:NamedThing microbeam A microbeam is a narrow beam of radiation, of micrometer or sub-micrometer dimensions. Together with integrated imaging techniques, microbeams allow precisely defined quantities of damage to be introduced at precisely defined locations. RBO_relaxed.owl OBO:RBO_00000050 biolink:NamedThing nuclear reactor radiation Radiation produced by a nuclear reactor. RBO_relaxed.owl OBO:RBO_00000051 biolink:NamedThing cesium-137 gamma radiation High energy photons emitted during nuclear decay of the Cesium-137 isotope. RBO_relaxed.owl OBO:RBO_00000120 biolink:NamedThing gamma radiation electromagnetic radiation with photon energies greater than approximately 100 keV RBO_relaxed.owl OBO:RBO_00000052 biolink:NamedThing cobalt-60 gamma radiation High energy photons emitted during nuclear decay of the Cobalt-60 isotope. RBO_relaxed.owl OBO:RBO_00000058 biolink:NamedThing cobalt-57 gamma radiation High energy photons emitted during nuclear decay of the Cobalt-57 isotope. RBO_relaxed.owl OBO:RBO_00000061 biolink:NamedThing actinide A series of radioactive elements from ACTINIUM, atomic number 89, to and including LAWRENCIUM, atomic number 103 RBO_relaxed.owl OBO:RBO_00000062 biolink:NamedThing actinium A trivalent radioactive element and the prototypical member of the actinide family. It has the atomic symbol Ac, and atomic number 89. Its principal isotope is 227 and it decays primarily by beta-emission. RBO_relaxed.owl OBO:RBO_00000063 biolink:NamedThing americium A completely man-made radioactive actinide with atomic symbol Am, and atomic number 95. Its valence can range from +3 to +6. Because of its nonmagnetic ground state, it is an excellent superconductor. It is also used in bone mineral analysis and as a radiation source for radiotherapy RBO_relaxed.owl OBO:RBO_00000064 biolink:NamedThing californium A man-made radioactive actinide with atomic symbol Cf, atomic number 98, and atomic weight 251. Its valence can be +2 or +3. Californium has medical use as a radiation source for radiotherapy RBO_relaxed.owl OBO:RBO_00000065 biolink:NamedThing neptunium A radioactive element of the actinide metals family. It has the atomic symbol Np, and atomic number 93. RBO_relaxed.owl OBO:RBO_00000066 biolink:NamedThing plutonium A naturally radioactive element of the actinide metals series. It has the atomic symbol Pu, and atomic number 94. Plutonium is used as a nuclear fuel, to produce radioisotopes for research, in radionuclide batteries for pacemakers, and as the agent of fission in nuclear weapons. RBO_relaxed.owl OBO:RBO_00000067 biolink:NamedThing thorium A radioactive element of the actinide series of metals. It has an atomic symbol Th, atomic number 90, and atomic weight 232.04. It is used as fuel in nuclear reactors to produce fissionable uranium isotopes. Because of its radioopacity, various thorium compounds are used to facilitate visualization in roentgenography. RBO_relaxed.owl OBO:RBO_00000068 biolink:NamedThing uranium A radioactive element of the actinide series of metals. It has an atomic symbol U, atomic number 92, and atomic weight 238.03. U-235 is used as the fissionable fuel in nuclear weapons and as fuel in nuclear power reactors. RBO_relaxed.owl OBO:RBO_00000069 biolink:NamedThing ultraviolet radiation Electromagnetic radiation with photon energies approximately 3-120 eV. High energy UV radiation can be ioinizing. RBO_relaxed.owl OBO:RBO_00005013 biolink:NamedThing x-ray radiation Electromagnetic radiation with photon energies approximately between 0.1 and 120 keV. The upper end of the x-ray spectrum overlaps with the lower end of the gamma ray spectrum. RBO_relaxed.owl OBO:RBO_00000074 biolink:NamedThing peptide radiation response modifier Radiation response modifiers that are peptides. RBO_relaxed.owl OBO:RBO_00000075 biolink:NamedThing small molecule radiation response modifier Radiation response modifiers that are small molecules. RBO_relaxed.owl OBO:RBO_00000076 biolink:NamedThing nuclear industry worker A person employed or otherwise working in commercial activities where nuclear materials are created, handled or disposed and at risk of occupational radiation exposure. Excludes health workers. RBO_relaxed.owl OBO:RBO_00000077 biolink:NamedThing astronaut RBO_relaxed.owl OBO:RBO_00000078 biolink:NamedThing military RBO_relaxed.owl OBO:RBO_00000079 biolink:NamedThing medical professional RBO_relaxed.owl OBO:RBO_00000080 biolink:NamedThing dentist RBO_relaxed.owl OBO:RBO_00000081 biolink:NamedThing radiologist RBO_relaxed.owl OBO:RBO_00000083 biolink:NamedThing epidemiological study An epidemiological study is the study (scientific, systematic, and data-driven) of the distribution (frequency, pattern) and determinants (causes, risk factors) of health-related states and events (not just diseases) in specified populations (neighborhood, school, city, state, country, global) RBO_relaxed.owl OBO:RBO_00000084 biolink:NamedThing environmental study A study of the impact of radiation on the composition of or processes within the natural or anthropogenic environment. RBO_relaxed.owl OBO:RBO_00000085 biolink:NamedThing lifespan study A study who endpoint is the lifespan of the organism under investifgation. RBO_relaxed.owl OBO:RBO_00000086 biolink:NamedThing carcinogenesis study A study of the effect of agents including radiation, seperately or together, on the incidence or type of neoplasia or pre-neoplasia. RBO_relaxed.owl OBO:RBO_00000087 biolink:NamedThing tissue damage study A study in which the structural or processual damage to normal tissue caused by radiation is assessed. Often by histopathology or molecular profiling. RBO_relaxed.owl OBO:RBO_00000088 biolink:NamedThing dna damage and repair study A study of the mechanism or effects of radiation on dna damage and its repair. RBO_relaxed.owl OBO:RBO_00000089 biolink:NamedThing physiological study A study of the effects of internal or external radiation on cellular or organismal physiology. RBO_relaxed.owl OBO:RBO_00000090 biolink:NamedThing anatomical study A study of the effects of radiation on the integrity, composition and quality of adult, fetal or embryonic anatomical structures. RBO_relaxed.owl OBO:RBO_00000091 biolink:NamedThing external exposure study A study of the effects of external irradiation on an organism. RBO_relaxed.owl OBO:RBO_00000092 biolink:NamedThing internal contamination study A study of the effects of internal irradiation on an organism where the radiation source is internalised within the body tissues ( eg. by injection), gastrointestinal ( eg gavage), urogenital, auditory or respiratory ( eg instillation or inhalation) systems. RBO_relaxed.owl OBO:RBO_00000093 biolink:NamedThing mixed exposure route study A study of the effects of radiation exposure where the exposoure has an internal and external mode of application. RBO_relaxed.owl OBO:RBO_00000100 biolink:NamedThing gene expression study A study of the effects of radiation on gene expression. RBO_relaxed.owl OBO:RBO_00000101 biolink:NamedThing proteomics study A study of the effects of radiation on the proteome or individual proteins. RBO_relaxed.owl OBO:RBO_00000102 biolink:NamedThing marker discovery study A study that aims at the discovery of protein, RNA or other molecular entities or modifcations that can act as reliable surrogates for the prediction or measurement of the effects of radiation or the response of the organism to radiation. RBO_relaxed.owl OBO:RBO_00000103 biolink:NamedThing therapeutics study A study that aims at the discovery, development or assessment of efficacy of therapeutic agents or processes designed to mitigate or cure the effects of radiation exposure. RBO_relaxed.owl OBO:RBO_00000104 biolink:NamedThing survival study A study that uses survival as an endpoint. Generally applicable to animal studies rather than human studies which would use the "lifespan" measure (RBO:00000085) RBO_relaxed.owl OBO:RBO_00000105 biolink:NamedThing metabolomics study A study of the effects of radiation on the metabolome or individual metabolites. RBO_relaxed.owl OBO:RBO_00000106 biolink:NamedThing nuclear accident study A study of the contributing factors consequences and prevention of nuclear accidents RBO_relaxed.owl OBO:RBO_00000107 biolink:NamedThing toxicity study A study of the toxicity of chemical or biological agents on cells or whole organisms. RBO_relaxed.owl OBO:RBO_00000109 biolink:NamedThing offspring study A study of the effects of radiation on the offspring of an irradiated animal or plant. RBO_relaxed.owl OBO:RBO_00000110 biolink:NamedThing biokinetics study A study of the distribution and metabolism orf drugs or biologicals used for therapeutic purposes. RBO_relaxed.owl OBO:RBO_00002013 biolink:NamedThing social and psychosocial study Studies relating to human society and the interrelation of social and educational factors with individual thought and behaviour including mental illness. RBO_relaxed.owl OBO:RBO_00002015 biolink:NamedThing mass media study Studies on the distribution of information or opinion by technological means of communication that reach large numbers of people. RBO_relaxed.owl OBO:RBO_00002016 biolink:NamedThing preparedness study Studies on the civil, legal, and political preparedness for accidental or deliberate release of radioactive materials or radiation into the environment. RBO_relaxed.owl OBO:RBO_00002017 biolink:NamedThing clinical study Studies in which research is conducted with human subjects or on material of human origin in which the investigator directly interacts with human subjects, including the dveelopment of new technologies, understanding of the mechanisms of disease, therapy, clinical trials, epidemiology behaviousrand health services research. RBO_relaxed.owl OBO:RBO_00002018 biolink:NamedThing legal and governance study Study of the laws, statutes, ordinances, government or international treaty regulations or authoritative guidelines, as well as for legal controversy and court decisions, relating to the regulation of radiation safety, movement and containment of radioactive materials and the consequences for human health or the natural environment of radioactive contamination. RBO_relaxed.owl OBO:RBO_00002019 biolink:NamedThing security and law enforcement study Studies relating to organisations and processes concerned with freedom from or resilience towards potential harm caused by hostile intent or circumstances (for example terrorism and illegal release of radioactive substances or radiation) towards the natural environment or human population, and the enforcement of relevant laws and international treaties. RBO_relaxed.owl OBO:RBO_00002020 biolink:NamedThing cancer study A study whose intention is to discover knowledge concerning the origins, nature diagnosis or therapy for neoplastic disease and cancer. This includes studies in humans, model organisms, the laboratory and in silico. This class includes experimental and epidemiological studies specifically aimed at cancer. RBO_relaxed.owl OBO:RBO_00002022 biolink:NamedThing environmental study Studies of the presence of radiation of any type in the natural or anthropogenic environment and its impact on animals, plants, and microorganisms. This includes studies measuring nuclide transfer in the environment, and interaction with meteorological phenomena. This excludes occupational exposure and the human working environment. RBO_relaxed.owl OBO:RBO_00002023 biolink:NamedThing nuclear industry study Studies concerned with the regulation, monitoring and operation of the nuclear industry. For example nuclear power station and reprocessing plants, isotope purification and manufactore, weapons manufacture and testing. This includes occupation health studies, impact of accidental or deliberate release on the natural or man made environment and impact on organisms specifically affected directly or indirectly by contamination. RBO_relaxed.owl OBO:RBO_00002024 biolink:NamedThing laboratory study Research done in a laboratory. A laboratory study may use special equipment and cells or animals to investigate the effects of an experimental perturbation, discover fundamental molecular mechanisms, assay biological substances, or find out if a drug, procedure, or treatment is likely to be useful in humans. A laboratory investigation is often characterised by a hypothesis and is carried out with controls. RBO_relaxed.owl OBO:RBO_00005026 biolink:NamedThing ground analog study A study at a ground facility designed so as to replicate one or more conditions in space (e.g. radiation, microgravity, isolation) RBO_relaxed.owl OBO:RBO_00005027 biolink:NamedThing ground control study An study at a ground facility designed so as to replicate conditions in space (e.g. radiation, microgravity, isolation) with the exception of one condition, so as to ascertain the effects of that condition on an organism or instrument RBO_relaxed.owl OBO:RBO_00005037 biolink:NamedThing adaptive radiation response study A study of a response to radiation conditioned by prior administration of radiation of a different type and/or at a different dose or dose rate RBO_relaxed.owl OBO:RBO_00015023 biolink:NamedThing mixed irradiation study A mixed irradiation study typically involves exposing a sample or system to a combination of different types of radiation. This could include exposure to various forms of ionizing radiation, such as gamma rays, X-rays, and particle radiation. Exposure might be simultaneous or sequential and from anthropogenic or natural sources of radiation. The goal is to understand how the different types of radiation interact with each other and their combined effects on the material or biological system under investigation. RBO_relaxed.owl OBO:RBO_00000094 biolink:NamedThing acute external exposure study A study of the effects of external irradiation on an organism where the most of the dose is given in a single or small number of fractions closely in time. RBO_relaxed.owl OBO:RBO_00000095 biolink:NamedThing chronic external exposure study A study of the effects of external irradiation on an organism where the dose is given over a protracted time period either continuously or in many fractions. Often these are lose dose studies. RBO_relaxed.owl OBO:RBO_00000096 biolink:NamedThing chronic internal contamination study A study of the effects of internal irradiation on an organism where the radiation source is internalised within the body tissues ( eg. by injection), gastrointestinal ( eg gavage), urogenital, auditory or respiratory ( eg instillation or inhalation) systems. The dose is delivered over a long period of time, often continuously and generlly at low dose. For example long term Radon exposure by inhalation. RBO_relaxed.owl OBO:RBO_00000097 biolink:NamedThing acute internal contamination study A study of the effects of internal irradiation on an organism where the radiation source is internalised within the body tissues ( eg. by injection), gastrointestinal ( eg gavage), urogenital, auditory or respiratory ( eg instillation or inhalation) systems. Most of the dose is given over a short period of time and is generally unfractionated, such as in brachytherapy. RBO_relaxed.owl OBO:RBO_00000098 biolink:NamedThing acute mixed exposure route study A study of the effects of radiation exposure where the exposoure has an internal and external mode of application. Acute exposure involves usually a single exposure over a short period of time with no fractionation. RBO_relaxed.owl OBO:RBO_00000099 biolink:NamedThing chronic mixed exposure route study A study of the effects of radiation exposure where the exposoure has an internal and external mode of application. Chronic exposure involves usually a continuous or highly fractionated exposure over a long period of time. RBO_relaxed.owl OBO:RBO_00000108 biolink:NamedThing endocrine study A study of the effects of radiation on the endocrine system or of endocrine hormones on the effects of radiation. RBO_relaxed.owl OBO:RBO_00000118 biolink:NamedThing risk estimate RBO_relaxed.owl OBO:RBO_010015 biolink:NamedThing quality factor Dimensionless factor developed for purposes of radiation protection and assessing health risks in general terms that accounts for the relative biological effectiveness of different radiations in producing stochastic effects and is used to relate absorbed RBO_relaxed.owl OBO:RBO_010018 biolink:NamedThing radiation weighting factor A factor used to allow for differences in the biological effectiveness between different radiations when calculating equivalent dose (H_T) (see equivalent dose). These factors are independent of the tissue or organ irradiated. RBO_relaxed.owl OBO:RBO_00000119 biolink:NamedThing lifetime risk estimate RBO_relaxed.owl OBO:RBO_00005039 biolink:NamedThing gamma irradiator A device which exposes samples to gamma radiation. RBO_relaxed.owl OBO:RBO_00005070 biolink:NamedThing ionizing radiation device A device for exposing materials or biological organisms to ionizing radiation for research or therapeutic purposes. RBO_relaxed.owl OBO:RBO_00000124 biolink:NamedThing cellular process RBO_relaxed.owl OBO:RBO_00002009 biolink:NamedThing accidental anthropogenic radiation exposure Accidental or incidental exposure to radiation from a man made process or machine. Covers both radiation accidents and routine occupational exposure. RBO_relaxed.owl OBO:RBO_00002003 biolink:NamedThing medical diagnostic radiation exposure Planned exposure of an organism to radiation of any type, internally or externally, with the intention to effect a diagnosis of disease. RBO_relaxed.owl OBO:RBO_00002005 biolink:NamedThing medical therapeutic radiation exposure Planned exposure of an organism to radiation of any type, internally or externally, with the intention to effect a cure or mitigation of disease. RBO_relaxed.owl OBO:RBO_00015020 biolink:NamedThing internal experimental radiation exposure Planned exposure of an entity to radiation of any type, for example as part of a medical or experimental procedure with the intention of exposing the entity to radiation energy internally by the ingestion, inhalation or implantation of a source of radiation. RBO_relaxed.owl OBO:RBO_00002006 biolink:NamedThing accidental non-medical anthropogenic radiation exposure Unplanned exposure to anthropogenic radiation of any type in any environment ; for example radiation from nuclear waste, nuclear industry discharge or weapons. RBO_relaxed.owl OBO:RBO_00002010 biolink:NamedThing accidental medical anthropogenic radiation exposure Accidental exposure occurring during medical therapy or diagnostics, for example medical radiation accidents or overdoses. RBO_relaxed.owl OBO:RBO_00002011 biolink:NamedThing unplanned naturally occurring radiation exposure Incidental exposure to naturally occurring radiation in a natural or anthropogenic environment, such as geographical areas with high background levels of radiation or specific locations such as Uranium mines. RBO_relaxed.owl OBO:RBO_00002012 biolink:NamedThing planned naturally occurring radiation exposure Deliberate or knowing exposure to naturally occurring radiation in a natural or anthropogenic environment, such as a radon spa. RBO_relaxed.owl OBO:RBO_00002025 biolink:NamedThing attitudinal study Study of the status or origins of a mental position, feeling or emotion toward a fact or state with respect to information or experience concerning radiation, radiation safety or ethicolegal constructs surrounding radiation and radiation safety and regulation. RBO_relaxed.owl OBO:RBO_00002026 biolink:NamedThing communication study Study concerning exchange or transmission of thoughts, messages, or information between people or between authorities and the general public (for example educational information, risk communication, safety communication) concerning exposure to and use of radiation. RBO_relaxed.owl OBO:RBO_00002027 biolink:NamedThing community study A study focussed on a set of people with some shared characteristic. The substance of shared element varies widely, from geography to a situation to interest to lives and values. The term is widely used to evoke sense of collectivity. For example communities collectively exposed to radioactive environmental contamination. RBO_relaxed.owl OBO:RBO_00002028 biolink:NamedThing political and psephological study The study of political involvement in radiation and nuclear regulation, military use, and safety as shown by inclusion in political manifestos and messaging by established or informal groups and its impact on voting patterns and democracy. RBO_relaxed.owl OBO:RBO_00002029 biolink:NamedThing psychometric study A study measuring "psychological" aspects of a person such as knowledge, skills, abilities, attitudes, or personality using defined scales. RBO_relaxed.owl OBO:RBO_00002030 biolink:NamedThing behavioural study A study of human or animal activity, in terms of motivation, direction, result, emotion, perception, or etiology. RBO_relaxed.owl OBO:RBO_00002031 biolink:NamedThing sociological study A study dealing with group relationships, patterns of collective behavior, and social organization. RBO_relaxed.owl OBO:RBO_00002032 biolink:NamedThing social science and humanities study Studies involving fields of inquiry into human constructs and concerns as opposed to natural processes . These are traditionally the study of literature, philosophy, and religion. Included in this definition are sociological studies, especially those concerned with the social impact of the humanities. RBO_relaxed.owl OBO:RBO_00002033 biolink:NamedThing perceptions, expectations and behaviours study Specifically an attitudinal study looking at how perception, for example of risk, and expectations affect behaviour. RBO_relaxed.owl OBO:RBO_00002034 biolink:NamedThing holistic approaches to governance study Sociological, attitudinal, ethocolegal and regulatory approaches to governance of radiation and radioactive substance use. RBO_relaxed.owl OBO:RBO_00002035 biolink:NamedThing responsible research and innovation study Studies on policy concerning socially and ethically responsible research and innovation RBO_relaxed.owl OBO:RBO_00002036 biolink:NamedThing stakeholder engagement study Studies of the engagement between an organisational entity and those groups or individuals potentially or actually impacted by the actions of that entity over a range of activities and approaches. RBO_relaxed.owl OBO:RBO_00002037 biolink:NamedThing risk and health communication study Study concerning the modes, efficacy and response to communication of risk and health impacts of radiation in all aspects. RBO_relaxed.owl OBO:RBO_00002038 biolink:NamedThing radiological protection culture study Studies concenring the attitudes to and practices of radiological protection in defined groups of people. For example the nuclear industry of a country or within a specific laboratory. RBO_relaxed.owl OBO:RBO_00002039 biolink:NamedThing genetic population study Genetic study done at the population level or among population groups, generally to find the cause, incidence or spread of a disease or to see the response to a treatment, nutrition or environment. RBO_relaxed.owl OBO:RBO_00002040 biolink:NamedThing prospective study A type of study in which participants are enrolled into the study before they develop the disease or outcome in question. RBO_relaxed.owl OBO:RBO_00002041 biolink:NamedThing registry study Observational studies which include an organized system that uses observational methods to collect uniform data (clinical and other) prospectively for a population defined by a particular disorder/disease, condition (including susceptibility to a disorder), or exposure (including products, health care services, and/or procedures) and that serves a predetermined scientific, clinical, or policy purpose. Patient registries may be single purpose or on-going data collection programs that address one or more questions. (AHRQ) An observational study that is also considered to be a Patient Registry. RBO_relaxed.owl OBO:RBO_00002042 biolink:NamedThing retrospective study A study looking backwards in time using observations collected predominantly prior to subject selection and enrolment RBO_relaxed.owl OBO:RBO_00002043 biolink:NamedThing incidence or prevalence study A study of the number of new cases of a given disease during a given period in a specified population. It also is used for the rate at which new events occur in a defined population. this class also includes PREVALENCE, which refers to all cases in the population at a given time. RBO_relaxed.owl OBO:RBO_00002044 biolink:NamedThing situation awareness and decision support study Studies concerning the optimisation of situation awareness through gathering and analysing information, and methodologies for making decisions on that awareness, such as estimating the path of a radioactive fallout with respect to weather and population density and making a decision to evacuate a population. RBO_relaxed.owl OBO:RBO_00002045 biolink:NamedThing civil protection study A study concerning the protection of the population from unexpected radioactive discharge or contamination, such as a dirty bomb, and civil safetyy coningency plans, such as deployment of emergency services and evacuation. RBO_relaxed.owl OBO:RBO_00002046 biolink:NamedThing disaster planning study Studies on planning for unexpected natural or man-made radiological catastrophe of substantial extent causing significant property damage or destruction, loss of life or sometimes permanent changes to the natural environment. Broader scope than civil protection as may relate to livestock, food and water shortage, disease outbreak and extensive traumas caused by precipitating or consequential damage. RBO_relaxed.owl OBO:RBO_00002047 biolink:NamedThing nuclear accident study Studies on plannig for or analysing a nuclear accident with release of airborn or waterborn contamination into the environment. Narrower than Disaster planning study but may be used to qualify an annotation to Disaster planning study if the source of contamination is a nuclear accident. A nuclear accident is not necessarily a disaster. RBO_relaxed.owl OBO:RBO_00002048 biolink:NamedThing clinical trial study A controlled study designed to assess the safety and efficacy of new drugs, devices, treatments, or preventive measures in humans by comparing two or more interventions or regimens RBO_relaxed.owl OBO:RBO_00002049 biolink:NamedThing medical radiological safety study Study of the effects of radiation used in a medical therapeutic or diagnostic context. Inlcudes radiation accidents in this context, excludes occupational exposure for health professionals. RBO_relaxed.owl OBO:RBO_00002050 biolink:NamedThing occupational health study A study concerned with health and safety policy development, implementation and practice in the workplace including investigating accidents at work, and chronic occupational exposure. Includes monitoring compliance with health and safety legislation and study of the promotion and maintenance of physical and mental health in the work environment. RBO_relaxed.owl OBO:RBO_00002051 biolink:NamedThing radiation based diagnostics study Study on the efficacy, outcomes and adverse consequences of exposure to medical diagnostic procedures using internal or external irradiation. RBO_relaxed.owl OBO:RBO_00002052 biolink:NamedThing radiotherapy study Study of the efficacy, outcomes and adverse consequences of exposure to therapeutic use of ionizing and nonionizing radiation including RADIONUCLIDE THERAPY, therapeutic radiation with visible, laser, or ultraviolet light. Includes technical development of protocols and equipment. RBO_relaxed.owl OBO:RBO_00002053 biolink:NamedThing therapeutics study A study involvingdevelopment of agents or procedures intended to produce an effect that is intended to mitigate or stop a pathologic process. RBO_relaxed.owl OBO:RBO_00002054 biolink:NamedThing histopathologic study A study of the macroscopic and microscopic anatomical changes in diseased tissue. RBO_relaxed.owl OBO:RBO_00002055 biolink:NamedThing radiation legislation study Study of legal and statutory instruments and legislation designed to regulate the safety, use and transport of radioactive materials, release of such materials into the environment, or external radiation. RBO_relaxed.owl OBO:RBO_00002056 biolink:NamedThing regulatory harmonisation study Study of the policy approaches and their implementation concerned with harmonising regulatory guidelines and legislation dealing with radiation and radioactive substances between legislatures, generally internationally. RBO_relaxed.owl OBO:RBO_00002057 biolink:NamedThing nuclear proliferation treaty study Study of the development, implementation and monitoring of nuclear non proliferation treaties between states. RBO_relaxed.owl OBO:RBO_00002058 biolink:NamedThing bioterrorism study Studies concerning intentional release of organisms (germs), toxic chemicals, or radioactive substances with intent to harm or kill people or the environment, or to inflict panic within a population. RBO_relaxed.owl OBO:RBO_00002059 biolink:NamedThing military defence study Study of strategies and their implementation towards defence against radiation used as a weapon conducted by military powers and institutions. May also include civil defence where the military has a significant operational role, but not disaster preparedness. RBO_relaxed.owl OBO:RBO_00002060 biolink:NamedThing dna modification study Study of biological processes that involve adding/removing chemical moieties to/from DNA, including methylation, phosphorylation, dephosphorylation, etc. Includes interventional DNA modification. RBO_relaxed.owl OBO:RBO_00002061 biolink:NamedThing histone modification study Study of biological processes that involve adding/removing chemical moieties to/from histones, including methylation, acetylation,phosphorylation, dephosphorylation, etc. RBO_relaxed.owl OBO:RBO_00002062 biolink:NamedThing interview study Study conducted by means of structured or unstructured interviews of persons of interest. RBO_relaxed.owl OBO:RBO_00002063 biolink:NamedThing genetic study A study of genetic variation and the inheritance of a trait or traits within a population or an individual including examination of genetic material for the presence or absence of cytogenetic or molecular genetic abnormalities. RBO_relaxed.owl OBO:RBO_00002064 biolink:NamedThing imaging study A radiographic study used to evaluate a specific anatomic location for a specific purpose. This may include the assessment of imaging modalities and the development of new techniques. Includes PET, MRI, CT and related techniques. RBO_relaxed.owl OBO:RBO_00002065 biolink:NamedThing mathematical modelling study Study concerned with the construction, analysis, evaluation, refinement etc. of mathematical or statistical models of the properties or behaviour of a set of entities, such as molecules, physiological processes, environmental processes such as nuclide transfer, such that functions are developed to reliably predict the behaviour of those entities. RBO_relaxed.owl OBO:RBO_00002066 biolink:NamedThing model organism study A study usually conducted in a laboratory where non human animals are used to model aspects of a disease process or its therapy to provide insights into human biology or pathobiology. RBO_relaxed.owl OBO:RBO_00002067 biolink:NamedThing monitoring technologies and metrology study Study concerning the development, use, calibration or standardisation of technologies for the qualitative or quantitative measurement of radiation and radionuclides. RBO_relaxed.owl OBO:RBO_00002068 biolink:NamedThing radiochemistry study Study of the chemistry of radioactive materials including radioactive tracer studies of metabolic processes RBO_relaxed.owl OBO:RBO_00002069 biolink:NamedThing policy development study Study of the development and implementation of public policy towards issues involving radiation RBO_relaxed.owl OBO:RBO_00002070 biolink:NamedThing acoustic radiation study Study of the effects of acoustic radiation on cellular and organismal physiology and the effects of acoustic radiation emitted in response to exposure to ionising radiation. RBO_relaxed.owl OBO:RBO_00002071 biolink:NamedThing environmental study_ abiotic_anthropogenic Study of radiation levels and effects in the human built environment. RBO_relaxed.owl OBO:RBO_00002072 biolink:NamedThing natural environment study Study of radiation levels and effects in the natural environment. RBO_relaxed.owl OBO:RBO_00002073 biolink:NamedThing ecological population modelling study The development and use of mathematical models and systems analysis for the description of naturally occurring non-human populations, and applications to measuring the effects of radiological contamination. RBO_relaxed.owl OBO:RBO_00002074 biolink:NamedThing ecotoxicology study The study of environmental contamination with radiation and radioactive substances and the toxic effects on the ecosystem either through chemical toxicity or radiation exposure. RBO_relaxed.owl OBO:RBO_00002075 biolink:NamedThing environmental radon study The study of environmental contamination with radon and the toxic effects on biota including humans. Both natural and anthropogenic environments. Includes radiometrics, safety policies and mitigation technologies. RBO_relaxed.owl OBO:RBO_00002076 biolink:NamedThing radionuclide dispersal modelling study Mathematical modelling of radionuclide transfer and dispersal processes in water, earth or air, either directly or through the mediation of biota. RBO_relaxed.owl OBO:RBO_00002077 biolink:NamedThing naturally occurring radioactive materials study Study of the ocurrence, levels and effects of naturally occurring radioactive materials such as Radon. RBO_relaxed.owl OBO:RBO_00002078 biolink:NamedThing environmental radiation monitoring study Study involving the measurement of radiation levels, or concentration of radionuclides, in the natural or man made environment. Usually in a time series. RBO_relaxed.owl OBO:RBO_00002079 biolink:NamedThing environmental radionuclide transfer study Study concerned with the measurement of transfer of radionuclides to biota from the environment. RBO_relaxed.owl OBO:RBO_00002080 biolink:NamedThing non ionising electromagnetic radiation study Any study concenrd with the prevalence or effects on non-ionising radiations such as UV, acoustic, or RF. RBO_relaxed.owl OBO:RBO_00002081 biolink:NamedThing nuclear installation study Study concerning the safety, regulation, activities and engineering of nuclear installations including power stations, waste processing plant, radionuclide generation and purification plant, and military nuclear establishments. May include occupational health studies if broader than just occupationaal health in scope. RBO_relaxed.owl OBO:RBO_00002082 biolink:NamedThing nuclear waste study Study of the process of generation of nuclear waste, its monitoring, regulation, disposal and inadvertent discharge. RBO_relaxed.owl OBO:RBO_00002083 biolink:NamedThing nuclear engineering study Study of the engineering of nuclear installations such as power plants. RBO_relaxed.owl OBO:RBO_00002084 biolink:NamedThing mining study Study of the process, regulation and monitoring of mines where exposure to naturally occurring radiation presents an occupational hazard for workers or the process itself, for example run off water or spoil, constitutes an environmental hazard. RBO_relaxed.owl OBO:RBO_00002085 biolink:NamedThing cell culture study A study using cells derived from an organism grown in artificial culture medium in a laboratory with the aim of understanding some aspect(s) of cell physiology, genetics or behaviour, generally as part of the testing of an hypothesis but also for diagnostic intent. RBO_relaxed.owl OBO:RBO_00002086 biolink:NamedThing organ culture study A study using an organ, part of an organ or an organoid culture, derived from an organism and grown in artificial culture medium in a laboratory with the aim of understanding some aspect(s) of cell physiology, genetics or behaviour, generally as part of the testing of an hypothesis but also for diagnostic intent. The system differs from cell culture in the generation or maintenance of multiple cell types with the spatial and functional relationship between them derived from or reflecting the normal organisation in vivo. RBO_relaxed.owl OBO:RBO_00002087 biolink:NamedThing molecular genetic study Any study involving the manipulation, measurement, or characterisation of DNA or RNA in a cell or organism. RBO_relaxed.owl OBO:RBO_00002088 biolink:NamedThing molecular structural study Elucidation of the physical structure of a macromolecule, protein, carbohydrate, DNA or RNA, its analysis and manipulation based on structure/function considerations. RBO_relaxed.owl OBO:RBO_00002089 biolink:NamedThing whole organism study A study using an intact organism, plant, animal, or microorganism RBO_relaxed.owl OBO:RBO_00002090 biolink:NamedThing bystander effect study Study of the cellular phenomenon which radiation energy is not been directly deposited in cells by transfer of medium, proximity/justaposition, or other means, but results in their behaving as if they had been irradiated. RBO_relaxed.owl OBO:RBO_00002091 biolink:NamedThing epigenetic study A study of heritable phenotype changes that do not involve alterations in the DNA sequence. This may be in intact organisms or in cells and includes population analysis of epigenetic phenomena and molecular analysis of gene expression and epigenetic modifications of chromatin such as DNA methylation and histone acetylation. RBO_relaxed.owl OBO:RBO_00002092 biolink:NamedThing mutagenesis study Study of the frequency of induction , nature and consequences of the production of genetic or epigenetic alterations by any technique, including chemicals, radiation, recombination, or other molecular biology methods. RBO_relaxed.owl OBO:RBO_00002093 biolink:NamedThing attitudinal study of nuclear industry risk perception Studies of the status or origins of a mental position, feeling or emotion toward a fact or state with respect to information or experience concerning radiation, radiation safety or regulation of the nuclear industries. RBO_relaxed.owl OBO:RBO_00002094 biolink:NamedThing attitudinal study towards ionising radiation in the environment Studies of the status or origins of a mental position, feeling or emotion toward a fact or state with respect to information or experience concerning radiation, radiation safety or ecological integrity towards natural or anthropogenic ionising radiation in the environment. RBO_relaxed.owl OBO:RBO_00002095 biolink:NamedThing attitudinal study towards non-ionising radiation in the environment Studies of the status or origins of a mental position, feeling or emotion toward a fact or state with respect to information or experience concerning radiation, radiation safety or ecological integrity towards natural or anthropogenic non-ionising radiation in the natural environment. RBO_relaxed.owl OBO:RBO_00002096 biolink:NamedThing attitudinal study towards medical radiation procedures Studies of the status or origins of a mental position, feeling or emotion toward a fact or state with respect to information or experience concerning radiation, radiation safety and efficacy in a clinical context where radiation is used for diagnostic or therapeutic procedures.. RBO_relaxed.owl OBO:RBO_00002097 biolink:NamedThing attitudinal study towards radiation in the occupational environment Studies of the status or origins of a mental position, feeling or emotion toward a fact or state with respect to information or experience concerning radiation, radiation safety towards natural or anthropogenic non-ionising radiation in the occupational environment. RBO_relaxed.owl OBO:RBO_00002098 biolink:NamedThing authority trust study Study of social and individual trust in the position and activities of legal or other competent advisory or regulatory authorities. RBO_relaxed.owl OBO:RBO_00002099 biolink:NamedThing risk communication study Study on the modality, efficacy and responses to communcation of information or advice to populations or individuals, on the safety and risks of exposure to ionising radiation in any context. RBO_relaxed.owl OBO:RBO_00002100 biolink:NamedThing public communication study Study on the modality, efficacy and responses to communication of information or advice to populations or individuals, on the safety and risks of exposure to ionising radiation in any context. RBO_relaxed.owl OBO:RBO_00002101 biolink:NamedThing public education study Study on the modality, efficacy and responses to communication of information or advice to populations on any aspect of radiation, conceived of as an educational programme, and including a wider scope than just safety and risk. For example basic nuclear physics, emergency action advice. RBO_relaxed.owl OBO:RBO_00002102 biolink:NamedThing social affairs and community health study Study involving attitudes, health status, social organisation of defined communities identified by common characteristics such as occupation type, geography, gender identity, with respect to radiation. RBO_relaxed.owl OBO:RBO_00002103 biolink:NamedThing community planning study Studies involving creation and assessment of plans for the future physical arrangement, well being, efficiency and condition of a community. It may have the goals of improving health, promoting efficiency in the provision of services and resources on a comprehensive basis for a whole community. In the context of radiation this may be concerned with community planning for dealing with mitigation measures for local NORM, or organised community-wide continegency measures for nuclear accident or recovery from such. RBO_relaxed.owl OBO:RBO_00002104 biolink:NamedThing community survey study Study concerned with eliciting information in a structured way concerning issues of interest from members of a community defined by common characteristics, for example occupation, geographical location, personal history or gender. RBO_relaxed.owl OBO:RBO_00002105 biolink:NamedThing individual behaviour study A study concerned with human or animal activity, in terms of motivation, direction, result, emotion, perception, or etiology at the level of slected individuals. May be carried out by observation or as individual responses to a questioannaire or interview in the case of humans where the person records their own assessment of their behaviour. RBO_relaxed.owl OBO:RBO_00002106 biolink:NamedThing population behaviour study A study concerned with human or animal activity, in terms of motivation, direction, result, emotion, perception, or etiology within substantial populations of individuals. Likely to be carried out by mass observation or indirect inference. RBO_relaxed.owl OBO:RBO_00002107 biolink:NamedThing radiotherapeutic modelling study Mathematical modelling for theraputic regime optimisation and for optimal tumor response, for example modelling spatiotemporal dynamics of tumor and blood volume fraction, and predicting response to radiation therapy. Also studies for beam modelling and multiimaging techniques. RBO_relaxed.owl OBO:RBO_00002108 biolink:NamedThing building materials radiological safety study Study of the radiolonuclide components and emissions from building materials RBO_relaxed.owl OBO:RBO_00002109 biolink:NamedThing building radiological safety study Studies on radiological safety within buildings. Primary purpose os for buildings not specifially designed to hold radioactive materials but anaylyis and mitigation of risks from radioactive exposure from the local environment or materials. RBO_relaxed.owl OBO:RBO_00002110 biolink:NamedThing meteorology study Study of the weather and atmospheric dynamics mainly with respect to dissemination of radionuclides. RBO_relaxed.owl OBO:RBO_00002111 biolink:NamedThing environmental study_abiotic Study of non-living objects in the environment, such as soils or rocks. RBO_relaxed.owl OBO:RBO_00002112 biolink:NamedThing environmental study_biota ( non human) Study of non-human biota in the natural environment. RBO_relaxed.owl OBO:RBO_00002113 biolink:NamedThing environmental study_panbiota (all) Study which may include human and non-human biota in the environment. RBO_relaxed.owl OBO:RBO_00002114 biolink:NamedThing wireless communication radiation study Study of the measurement, effects and regulation of wireless communication signals, for example mobile phone radiation and microwave communication. RBO_relaxed.owl OBO:RBO_00002115 biolink:NamedThing gamma ray photon Photons having energies that are greater than tens of thousands of electron volts (eV). RBO_relaxed.owl OBO:RBO_00002116 biolink:NamedThing x-ray photon A photon with energies from about 100 eV (electron volts) to 1 MeV (million electron volts). RBO_relaxed.owl OBO:RBO_00015021 biolink:NamedThing energy deposition event The direct or indirect transfer of energy from radiation to a medium through ionisation or excitation of the atoms of the medium. RBO_relaxed.owl OBO:RBO_00002120 biolink:NamedThing unplanned anthropogenic irradiation Unplanned irradiation that is of anthropogenic origin RBO_relaxed.owl OBO:RBO_00002121 biolink:NamedThing unplanned naturally occurring radiation exposure Unplanned irradiation that is non-anthropogenic in origin RBO_relaxed.owl OBO:RBO_00002125 biolink:NamedThing anthropogenic environment radiation monitoring Monitoring for radiation dose or quality within a man-made or constructed environment such as a building or a vehicle. RBO_relaxed.owl OBO:RBO_00002126 biolink:NamedThing natural environment radiation monitoring Monitoring for radiation dose or quality within a natural environment. RBO_relaxed.owl OBO:RBO_00005002 biolink:NamedThing light ion radiation Atomic nuclei, variously defined as having atomic number 2, 3, 4, 5 or 6 and kinetic energy imparted by natural or artificial means RBO_relaxed.owl OBO:RBO_010006 biolink:NamedThing delta ray Highly energetic electrons produced during inelastic collisions between ionizing radiation and atomic electrons. In a small proportion of collisions, the ejected electron receives a considerable amount of energy (i.e., >1,000 eV), allowing it to travel a RBO_relaxed.owl OBO:RBO_00005004 biolink:NamedThing Iron-56 nucleus An atomic nucleus with 26 protons and 30 neutrons RBO_relaxed.owl OBO:RBO_00005005 biolink:NamedThing Silicon-28 nucleus An atomic nucleus with 14 protons and 14 neutrons RBO_relaxed.owl OBO:RBO_00005006 biolink:NamedThing Carbon-12 nucleus An atomic nucleus with 6 protons and 6 neutrons RBO_relaxed.owl OBO:RBO_00005007 biolink:NamedThing Helium-4 nucleus An atomic nucleus with 2 protons and 2 neutrons RBO_relaxed.owl OBO:RBO_00005008 biolink:NamedThing Neon-20 nucleus An atomic nucleus with 10 protons and 10 neutrons RBO_relaxed.owl OBO:RBO_00005048 biolink:NamedThing Niobium-93 nucleus An atomic nucleus with 41 protons and 52 neutrons RBO_relaxed.owl OBO:RBO_00005049 biolink:NamedThing Silver-107 nucleus An atomic nucleus with 47 protons and 60 neutrons RBO_relaxed.owl OBO:RBO_00005050 biolink:NamedThing Xenon-129 nucleus An atomic nucleus with 54 protons and 75 neutrons RBO_relaxed.owl OBO:RBO_00005051 biolink:NamedThing Tantalum-181 nucleus An atomic nucleus with 73 protons and 108 neutrons RBO_relaxed.owl OBO:RBO_00005052 biolink:NamedThing Gold-197 nucleus An atomic nucleus with 79 protons and 118 neutrons RBO_relaxed.owl OBO:RBO_00005053 biolink:NamedThing Nitrogen-14 nucleus An atomic nucleus with 7 protons and 7 neutrons RBO_relaxed.owl OBO:RBO_00005054 biolink:NamedThing Oxygen-16 nucleus An atomic nucleus with 8 protons and 8 neutrons RBO_relaxed.owl OBO:RBO_00005055 biolink:NamedThing Argon-40 nucleus An atomic nucleus with 18 protons and 22 neutrons RBO_relaxed.owl OBO:RBO_00005056 biolink:NamedThing Titanium-48 nucleus An atomic nucleus with 22 protons and 26 neutrons RBO_relaxed.owl OBO:RBO_00005057 biolink:NamedThing Krypton-84 nucleus An atomic nucleus with 36 protons and 48 neutrons RBO_relaxed.owl OBO:RBO_00005011 biolink:NamedThing absorbed radiation dose rate The amount of energy from any type of ionizing radiation deposited in a specified mass of any medium per unit time. RBO_relaxed.owl OBO:RBO_00005030 biolink:NamedThing radiation fraction interval Time between fractions in a fractionated irradiation. RBO_relaxed.owl OBO:RBO_00005038 biolink:NamedThing average fractionated dose rate The total dose administered in a series of radiation fractions divided by the elapsed time between the beginning of the first exposure fraction and the end of the last exposure fraction RBO_relaxed.owl OBO:RBO_00005015 biolink:NamedThing sham irradiation Sham irradiation refers to a procedure in which participants or subjects in an experiment are exposed to simulated radiation, mimicking precisely the conditions of actual irradiation. The purpose of using sham irradiation is to create a control group that experiences the non-specific effects of the experimental setup, while excluding the specific effects associated with radiation exposure. RBO_relaxed.owl OBO:RBO_00005028 biolink:NamedThing irradiation protocol A protocol for administering radiation to a sample RBO_relaxed.owl OBO:RBO_00005029 biolink:NamedThing radiation fraction One of the series of individual doses administered to a sample in a fractionated irradiation. RBO_relaxed.owl OBO:RBO_00005031 biolink:NamedThing high altitude The region of the atmosphere above 8000 feet above sea level. Altitudes above 12000 feet are sometimes referred to as very high altitude, and above 18000 feet as extremely high altitude. RBO_relaxed.owl OBO:RBO_00005032 biolink:NamedThing sham-irradiated A quality of a biotic or abiotic sample or individual which is part of an experiment that tests the effects of radiation on organisms or materials by isolating variables as dictated by the scientific method in order to make a conclusion about the effect of such variables. In sham irradiation the precise treatment of the sample must be identical to that of the experimental samples and should be made explicit in the description of the method. RBO_relaxed.owl OBO:RBO_00005033 biolink:NamedThing parabolic flight aircraft An aircraft which flies a series of parabolic arcs to simulate micrgravity. RBO_relaxed.owl OBO:RBO_00005034 biolink:NamedThing high altitude research aircraft An aircraft which flies at altitudes greater than commercial aircraft altitudes for research purposes. RBO_relaxed.owl OBO:RBO_00005035 biolink:NamedThing uncrewed aerial vehicle An research aircraft designed to operate without crew members, either autonomously or under control from a ground station RBO_relaxed.owl OBO:RBO_00005071 biolink:NamedThing high-altitude balloon High-altitude balloons are crewed or uncrewed balloons, usually filled with helium or hydrogen, that are released into the stratosphere, generally attaining between 18 and 37 km (11 and 23 mi; 59,000 and 121,000 ft) above sea level. RBO_relaxed.owl OBO:RBO_00005040 biolink:NamedThing particle charge The electric charge of a particle used in an irradiation RBO_relaxed.owl OBO:UO_0000219 biolink:NamedThing electric charge RBO_relaxed.owl OBO:UO_1000220 biolink:NamedThing coulomb based unit RBO_relaxed.owl OBO:RBO_00005041 biolink:NamedThing radiation dosimetry The measurement of the amount of radiation taken up by a sample. RBO_relaxed.owl OBO:RBO_010002 biolink:NamedThing biodosimetry Use of a biological response as an indicator of a dose of an effective agent (e.g., the extent of decline in peripheral blood lymphocytes of humans exposed to ionizing radiation can be used as an indicator of the absorbed dose to the whole body from that RBO_relaxed.owl OBO:RBO_00005066 biolink:NamedThing miligray per second A derived absorbed dose unit which is equal to one milligray absorbed per second RBO_relaxed.owl OBO:UO_0000129 biolink:NamedThing absorbed dose unit A derived unit which is a standard measure of the energy imparted by ionizing radiation to unit mass of matter such as tissue.|A unit which is a standard measure of the energy imparted by ionizing radiation to unit mass of matter such as tissue. RBO_relaxed.owl OBO:UO_0010063 biolink:NamedThing milligray per day RBO_relaxed.owl OBO:UO_0010064 biolink:NamedThing milligray per hour RBO_relaxed.owl OBO:UO_0010065 biolink:NamedThing milligray per second RBO_relaxed.owl OBO:UO_1000134 biolink:NamedThing gray based unit RBO_relaxed.owl OBO:UO_1010060 biolink:NamedThing gray per minute based unit RBO_relaxed.owl OBO:RBO_00005068 biolink:NamedThing indirect cellular response to radiation Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of radiation acting on another cell and not on the responding cell. The process begins with detection of radiation by a cell or cells and ends with a change in state or activity of a different cell or cells. RBO_relaxed.owl OBO:RBO_00005069 biolink:NamedThing indirect cellular response to ionising radiation Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of exposure to ionising radiation which acts on another cell and not on the responding cell. The process begins with detection of the ionising radiation by one cell or cells and ends with a change in state or activity of a different cell or cells. RBO_relaxed.owl OBO:RBO_00005074 biolink:NamedThing non-targeted effects of ionising radiation Non-targeted effects of ionising radiation are characterised by cellular responses that occur in cells in which energy from ionizing radiation has not been deposited. The distinct classes of non-targeted effects include Genomic Instability, and Bystander effect which latter includes Abscopal effects and Bystander-mediated adaptive response. These can also arise non-clonally in the progeny of irradiated somatic or germ cells, resulting in radiation-induced genomic instability and transgenerational genomic instability respectively. (Kadhim M, Salomaa S, Wright E, et al. Non-targeted effects of ionising radiation--implications for low dose risk. Mutat Res. 2013;752(2):84-98. doi:10.1016/j.mrrev.2012.12.001) RBO_relaxed.owl OBO:RBO_00015002 biolink:NamedThing nanodosimetry assay An assay of the pattern (frequency and spatial distribution) of ionization events produced by energy deposition in time and space in a substance characterized by linear dimensions of the order of 1-100 nanometers RBO_relaxed.owl OBO:RBO_00015003 biolink:NamedThing microdosimetry assay An assay of the pattern (frequency and spatial distribution) of ionization events produced by energy deposition in time and space in a substance characterized by linear dimensions of the order of 1-100 micrometers RBO_relaxed.owl OBO:RBO_00015004 biolink:NamedThing alpha decay Nuclear decay in which an alpha particle is emitted. RBO_relaxed.owl OBO:RBO_00015005 biolink:NamedThing beta decay Radioactive decay in which a beta particle is emitted or in which orbital electron capture occurs. RBO_relaxed.owl OBO:RBO_00015012 biolink:NamedThing ionization cluster A group of ionization events closely related in time and space, occurring in a specified target volume and originating from a single primary ionizing particle. RBO_relaxed.owl UBERON:0000104 biolink:NamedThing life cycle An entire span of an organism's life. In metazoans, commences with the zygote stage and ends with the death of the organism. RBO_relaxed.owl UBERON:0000105 biolink:NamedThing life cycle stage A spatiotemporal region encompassing some part of the life cycle of an organism. RBO_relaxed.owl OBO:RBO_00015015 biolink:NamedThing control specimen role A control specimen role of a biotic or abiotic sample or individual describes a specimen by its purpose, and therefore treatment, within a planned experimental process that tests hypotheses by isolating variables as dictated by the scientific method in order to make a conclusion about the effect of such variables. The quality of control inhering in the sample role exists as a result of the historical treatment of the sample. In a controlled experiment, two or more virtually identical experiments are conducted, but the factor being tested is varied in only one of them. This serves to isolate any causal phenomena. A control may have been subject to treatments during the experiment that might alter its state or behaviour and is therefore distinguishable from the sample as initial input into the experiment. However such treatments should in all cases but that of the variable under scrutiny, be the same as the experimental sample. RBO_relaxed.owl OBO:RBO_00015016 biolink:NamedThing approximate sham irradiation Sham irradiation in which an identical irradiation protocol (with the exception of the administration of the radiation exposure) is not followed in every respect. RBO_relaxed.owl OBO:RBO_00015019 biolink:NamedThing complete sham irradiation Sham irradiation in which an identical irradiation protocol is followed in every respect, with the exception of the administration of the radiation exposure. RBO_relaxed.owl OBO:RBO_00015024 biolink:NamedThing mixed ion and photon irradiation study A mixed ion and photon irradiation study typically involves exposing a sample or system to a combination of these types of radiation. This could include exposure to various forms of ionizing radiation, such as gamma rays, X-rays, and particle radiation. Exposure might be simultaneous or sequential and from anthropogenic or natural sources of radiation. The goal is to understand how the different types of radiation interact with each other and their combined effects on the material or biological system under investigation. RBO_relaxed.owl OBO:RBO_00015027 biolink:NamedThing multiple ion irradiation study A multiple ion irradiation study typically involves exposing a sample or system to a combination of different types of charged particle radiation. Exposure might be simultaneous or sequential and from anthropogenic or natural sources of radiation. The goal is to understand how the different types of radiation interact with each other and their combined effects on the material or biological system under investigation. RBO_relaxed.owl OBO:RBO_00015025 biolink:NamedThing mixed ion and photon simultaneous irradiation study A mixed ion and photon simultaneous irradiation study typically involves simultaneously exposing a sample or system to a combination of these types of radiation. This could include exposure to various forms of ionizing radiation, such as gamma rays, X-rays, and particle radiation. Exposure might be from anthropogenic or natural sources of radiation. The goal is to understand how the different types of radiation interact with each other and their combined effects on the material or biological system under investigation. RBO_relaxed.owl OBO:RBO_00015026 biolink:NamedThing mixed ion and photon sequential irradiation study A mixed ion and photon sequential irradiation study typically involves sequentially exposing a sample or system to a combination of these types of radiation. This could include exposure to various forms of ionizing radiation, such as gamma rays, X-rays, and particle radiation. Exposure might be from anthropogenic or natural sources of radiation. The goal is to understand how the different types of radiation interact with each other and their combined effects on the material or biological system under investigation. RBO_relaxed.owl OBO:RBO_00015028 biolink:NamedThing multiple ion simultaneous irradiation study A multiple ion simultaneous irradiation study typically involves simultaneously exposing a sample or system to a combination of ions. This could include exposure to various forms of particle radiation, for example ion beams. Exposure might be from anthropogenic or natural sources of radiation. The goal is to understand how the different types of radiation interact with each other and their combined effects on the material or biological system under investigation. RBO_relaxed.owl OBO:RBO_00015029 biolink:NamedThing multiple ion sequential irradiation study A multiple ion sequential irradiation study involves exposing a sample or system to a combination of different ions. This could include exposure to various forms of particle radiation such as ion beams. Exposure might be from anthropogenic or natural sources of radiation. The goal is to understand how the different types of radiation interact with each other and their combined effects on the material or biological system under investigation. RBO_relaxed.owl OBO:RBO_00015030 biolink:NamedThing anthropogenic background radiation Radiation present in an experimental or therapeutic process, other than that produced as part of that planned process. RBO_relaxed.owl OBO:RBO_00015031 biolink:NamedThing natural background radiation Radiation originating in the terrestrial or extra-terrestrial environment. RBO_relaxed.owl OBO:RBO_010001 biolink:NamedThing radiation attenuation The reduction of radiation intensity upon passage of radiation through matter RBO_relaxed.owl OBO:RBO_010003 biolink:NamedThing bystander effect The term used to describe the effects on cells in proximity to irradiated cells, but through which radiation has not passed. In experimental radiation biology, the bystander effect can be investigated by targeting individual cells, or by using doses low enough that the probability for a given cell to be hit by a particle is less than one. RBO_relaxed.owl OBO:RBO_010008 biolink:NamedThing excess lifetime risk of cancer The increased risk from induced cancer due to exposure when the effects over an entire lifetime are accounted for. Individuals who would have died of cancer anyway but die early because of exposure are not included RBO_relaxed.owl OBO:RBO_010009 biolink:NamedThing fast neutron Neutrons of energies above a few hundred kiloelectron volts (keV) RBO_relaxed.owl UBERON:0000005 biolink:NamedThing chemosensory organ RBO_relaxed.owl UBERON:0002536 biolink:NamedThing arthropod sensillum Sense organ embedded in the integument and consisting of one or a cluster of sensory neurons and associated sensory structures, support cells and glial cells forming a single organised unit with a largely bona-fide boundary.[FBbt]. RBO_relaxed.owl UBERON:0010521 biolink:NamedThing electroreceptor organ An organ that is capable of detecting electrical stimulus. RBO_relaxed.owl UBERON:6002639 biolink:NamedThing insect larval sense organ Any sense organ that is part of some larva. RBO_relaxed.owl UBERON:6007280 biolink:NamedThing insect embryonic/larval head sense organ Any sense organ (UBERON:6005155) that is part of some larval head (UBERON:6001730). RBO_relaxed.owl UBERON:0034922 biolink:NamedThing cell cluster A cluster of cells, largely surrounded by a morphological boundary. RBO_relaxed.owl UBERON:0000009 biolink:NamedThing submucosa A layer of dense irregular connective tissue that lines organs and supports the mucosa, as well as joins the mucosa to the bulk of underlying smooth muscle. [WP,unvetted]. RBO_relaxed.owl UBERON:0004923 biolink:NamedThing organ component layer A part of a wall of an organ that forms a layer. RBO_relaxed.owl UBERON:0000030 biolink:NamedThing lamina propria A thin layer of loose connective tissue which lies beneath the epithelium and together with the epithelium constitutes the mucosa[WP]. The lamina propria contains capillaries and a central lacteal (lymph vessel) in the small intestine, as well as lymphoid tissue. Lamina propria also contains glands with the ducts opening on to the mucosal epithelium, that secrete mucus and serous secretions. RBO_relaxed.owl UBERON:0000158 biolink:NamedThing membranous layer RBO_relaxed.owl UBERON:0004123 biolink:NamedThing myocardial layer Any of the layers of the myocardium. Example: compact layer, trabecular layer. RBO_relaxed.owl UBERON:0013754 biolink:NamedThing integumentary system layer An organ component layer that is part of a integumental system. RBO_relaxed.owl UBERON:0034933 biolink:NamedThing layer of smooth muscle tissue Any organ component layer that consists of smooth muscle tissue. RBO_relaxed.owl UBERON:0011216 biolink:NamedThing organ system subdivision A subdivision of an anatomical system. RBO_relaxed.owl UBERON:0000075 biolink:NamedThing subdivision of skeletal system Anatomical cluster consisting of the skeletal elements and articular elements that are part of an individual subdivision of the organism. RBO_relaxed.owl UBERON:0010191 biolink:NamedThing aortic system RBO_relaxed.owl UBERON:0010912 biolink:NamedThing subdivision of skeleton Anatomical cluster consisting of the skeletal elements (i.e. bone elements, cartilage elements, cartilage condensations) that are part of an individual subdivision of the organism. Excludes joints. RBO_relaxed.owl UBERON:0034944 biolink:NamedThing zone of organ RBO_relaxed.owl UBERON:0004914 biolink:NamedThing duodenal papilla One of the two small elevations on the mucosa of the duodenum, the major at the entrance of the conjoined pancreatic and common bile ducts and the minor at the entrance of the accessory pancreatic duct. RBO_relaxed.owl UBERON:0009870 biolink:NamedThing zone of stomach A division of the stomach. The stomach can be divided based on mucosal histology (glandular epithelium and gastric glands) and the relative position and type of gastric gland. RBO_relaxed.owl UBERON:0010188 biolink:NamedThing protuberance A roughly circular bulge in a surface. RBO_relaxed.owl UBERON:0000015 biolink:NamedThing non-material anatomical boundary A non-material anatomical entity of two dimensions. Anatomical boundaries are contiguous structures. RBO_relaxed.owl UBERON:0000464 biolink:NamedThing anatomical space Non-material anatomical entity of three dimensions, that is generated by morphogenetic or other physiologic processes; is surrounded by one or more anatomical structures; contains one or more organism substances or anatomical structures. RBO_relaxed.owl UBERON:0006846 biolink:NamedThing surface groove A furrow or an incomplete tube. RBO_relaxed.owl UBERON:0010199 biolink:NamedThing bona-fide anatomical boundary An anatomical boundary that corresponds to some physical discontinuity. RBO_relaxed.owl UBERON:0000471 biolink:NamedThing compound organ component Multi-tissue structure that is part of a compound organ. RBO_relaxed.owl UBERON:0000409 biolink:NamedThing serous gland A gland in which the principal secretory cells are serous secreting cells. RBO_relaxed.owl UBERON:0005177 biolink:NamedThing trunk region element An organ or element that part of the trunk region. The trunk region can be further subdividied into thoracic (including chest and thoracic cavity) and abdominal (including abdomen and pelbis) regions. RBO_relaxed.owl UBERON:0001774 biolink:NamedThing skeletal muscle of trunk A skeletal muscle organ that is part of the trunk region. RBO_relaxed.owl UBERON:0002075 biolink:NamedThing viscus An organ that is located within the body cavity (or in its extension, in the scrotum); it consists of organ parts that are embryologically derived from endoderm, splanchnic mesoderm or intermediate mesoderm; together with other organs, the viscus constitutes the respiratory, gastrointestinal, urinary, reproductive and immune systems, or is the central organ of the cardiovascular system. Examples: heart, lung, esophagus, kidney, ovary, spleen. RBO_relaxed.owl UBERON:0003463 biolink:NamedThing trunk bone A bone that is part of a trunk [Automatically generated definition]. RBO_relaxed.owl UBERON:0005173 biolink:NamedThing abdominal segment element An organ or element that is part of the adbominal segment of the organism. This region can be further subdivided into the abdominal cavity and the pelvic region. RBO_relaxed.owl UBERON:0005181 biolink:NamedThing thoracic segment organ An organ that part of the thoracic segment region. This region can be further subdividied chest and thoracic cavity regions. RBO_relaxed.owl UBERON:0000047 biolink:NamedThing simple eye An eye with one concave chamber. Note that 'simple' does not imply a reduced level of complexity or acuity. RBO_relaxed.owl UBERON:0000971 biolink:NamedThing ommatidium The smallest morphological and functional unit of the compound eye that consists of a usually limited and often constant number of rhabdomeric photoreceptor cells, cornea-secreting epithelial cells, and interommatidial pigment cells, and may additionally contain crystalline cone cells. RBO_relaxed.owl UBERON:0004548 biolink:NamedThing left eye An eye that is part of a left side of organism [Automatically generated definition]. RBO_relaxed.owl UBERON:0004549 biolink:NamedThing right eye An eye that is part of a right side of organism [Automatically generated definition]. RBO_relaxed.owl UBERON:0015165 biolink:NamedThing multi-unit eye An eye consisting of multiple light-sensing organs. RBO_relaxed.owl UBERON:0001605 biolink:NamedThing ciliary muscle The ciliary muscle is a ring of smooth muscle in the middle layer of the eye that controls the eye's accommodation for viewing objects at varying distances and regulates the flow of aqueous humour through Schlemm's canal. [WP,unvetted]. RBO_relaxed.owl UBERON:0001709 biolink:NamedThing upper jaw region Subdivision of head that consists of the upper jaw skeletal elements plus associated soft tissue (skin, lips, muscle)[cjm]. RBO_relaxed.owl UBERON:0001710 biolink:NamedThing lower jaw region Subdivision of head that consists of the lower jaw skeletal elements plus associated soft tissue (skin, lips, muscle)[cjm]. RBO_relaxed.owl UBERON:0002539 biolink:NamedThing pharyngeal arch One of a series of paired bulges that develop along the lateral walls of the foregut. The pharyngeal arches have developmental contributions from endoderm, mesoderm, and neural crest cells and are separated by anterior lateral endoderm out-pockets known as pharyngeal pouches. RBO_relaxed.owl UBERON:0003129 biolink:NamedThing skull Anatomical structure that is part of the head consisting entirely of cranium and mandible[WP]. RBO_relaxed.owl UBERON:0004363 biolink:NamedThing pharyngeal arch artery One of a series of paired embryological vascular structures formed within a pharyngeal arch; in the adult, some of these vessels give rise to the great vessels[MP]. RBO_relaxed.owl UBERON:0011595 biolink:NamedThing jaw region A subdivision of the head that corresponds to the jaw skeleton, containing both soft tissue, skeleton and teeth (when present). The jaw region is divided into upper and lower regions. RBO_relaxed.owl UBERON:0000220 biolink:NamedThing atlanto-occipital joint The Atlanto-occipital joint (articulation between the atlas and the occipital bone) consists of a pair of condyloid joints. The atlanto-occipital joint is a synovial joint. The ligaments connecting the bones are: Two Articular capsules; Posterior atlantoöccipital membrane; Anterior atlantoöccipital membrane; Lateral atlantoöccipital. RBO_relaxed.owl UBERON:0001145 biolink:NamedThing ovarian vein A vein that carries deoxygenated blood from its corresponding ovary to inferior vena cava or one of its tributaries. RBO_relaxed.owl UBERON:0001421 biolink:NamedThing pectoral girdle region An organism subdivision that includes the pectoral girdle skeleton and associated soft tissue. Note that this includes both the skeletal elements and associated tissues (integument, muscle, etc). Examples: There are only two instances in an organism, right and left pectoral girdle regions. RBO_relaxed.owl UBERON:0001534 biolink:NamedThing right subclavian artery The subclavian artery that supplies the right pectoral appendage. RBO_relaxed.owl UBERON:0001584 biolink:NamedThing left subclavian artery The subclavian artery that supplies the left pectoral appendage. RBO_relaxed.owl UBERON:0002118 biolink:NamedThing right ovary An ovary that is part of a right side of organism [Automatically generated definition]. RBO_relaxed.owl UBERON:0002119 biolink:NamedThing left ovary An ovary that is part of a left side of organism [Automatically generated definition]. RBO_relaxed.owl UBERON:0005460 biolink:NamedThing left vitelline vein A vitelline vein that is in the left side of a multicellular organism. RBO_relaxed.owl UBERON:0005472 biolink:NamedThing right vitelline vein A vitelline vein that is in the right side of a multicellular organism. RBO_relaxed.owl UBERON:0010707 biolink:NamedThing appendage girdle complex An organism subdivision that includes both an appendage and its associated girdle region. Note that this includes both the skeletal elements and associated tissues (integument, muscle, etc). RBO_relaxed.owl UBERON:0014766 biolink:NamedThing right crus of diaphragm A crus of diaphragm that is in_the_right_side_of a diaphragm. RBO_relaxed.owl UBERON:0014767 biolink:NamedThing left crus of diaphragm A crus of diaphragm that is in_the_left_side_of a diaphragm. RBO_relaxed.owl UBERON:0015280 biolink:NamedThing pancreas left lobe A pancreatic lobule that is in_the_left_side_of a exocrine pancreas. RBO_relaxed.owl UBERON:0015281 biolink:NamedThing pancreas right lobe A pancreatic lobule that is in_the_right_side_of a exocrine pancreas. RBO_relaxed.owl UBERON:0034713 biolink:NamedThing cranial neuron projection bundle Any of the cranial nerves, or their central nervous system analogs (the optic tract, the epiphyseal tract). These analogs are not true nerves, and are instead evaginated sensory afferents emanating from the brain. RBO_relaxed.owl UBERON:0035553 biolink:NamedThing left cardiac chamber Any chamber of the left side of the heart. RBO_relaxed.owl UBERON:0035554 biolink:NamedThing right cardiac chamber Any chamber of the right side of the heart. RBO_relaxed.owl UBERON:0035831 biolink:NamedThing costal diaphragm The domain of the diaphragm that is a thin domed sheet of muscle composed of a radial array of myofibers extending laterally from the ribs and medially to a central tendon. RBO_relaxed.owl UBERON:8000006 biolink:NamedThing left side of back Left part of the organism dorsal to a horizontal plane and bounded on one side by the same transverse plane. RBO_relaxed.owl UBERON:8000007 biolink:NamedThing right side of back Right part of the organism dorsal to a horizontal plane and bounded on one side by the same transverse plane. RBO_relaxed.owl UBERON:0000171 biolink:NamedThing respiration organ Organ that functions in gaseous exchange between an organism and its environment. In plants, microorganisms, and many small animals, air or water makes direct contact with the organism's cells or tissue fluids, and the processes of diffusion supply the organism with dioxygen (O2) and remove carbon dioxide (CO2). In larger animals the efficiency of gaseous exchange is improved by specialized respiratory organs, such as lungs and gills, which are ventilated by breathing mechanisms. RBO_relaxed.owl UBERON:0002535 biolink:NamedThing gill Anatomical surface structure found in many aquatic organisms. It is a respiration organ whose function is the extraction of oxygen from water and the excretion of carbon dioxide. The microscopic structure of a gill is such that it presents a very large surface area to the external environment. Gills usually consist of thin filaments of tissue, branches, or slender tufted processes which have a highly folded surface to increase surface area. A high surface area is crucial to the gas exchange of aquatic organisms as water contains only 1/20 parts dissolved Oxygen compared to air. With the exception of some aquatic insects, the filaments and lamellae (folds) contain blood or coelomic fluid, from which gases are exchanged through the thin walls. Oxygen is carried by the blood to other parts of the body. Carbon dioxide passes from the blood through the thin gill tissue into the water. Gills or gill-like organs, located in different parts of the body, are found in various groups of aquatic animals, including mollusks, crustaceans, insects, fish, and amphibians. RBO_relaxed.owl UBERON:0003133 biolink:NamedThing reproductive organ An organ involved in reproduction. RBO_relaxed.owl UBERON:0004765 biolink:NamedThing skeletal element Organ consisting of skeletal tissue. Encompasses whole bones, fused bones, cartilaginious elements, teeth, dermal denticles. RBO_relaxed.owl UBERON:0005057 biolink:NamedThing immune organ An organ that is part of a immune system [Automatically generated definition]. RBO_relaxed.owl UBERON:0005172 biolink:NamedThing abdomen element An organ or element that is in the abdomen. Examples: spleen, intestine, kidney, abdominal mammary gland. RBO_relaxed.owl UBERON:0005174 biolink:NamedThing dorsal region element An organ or element that part of the dorsum of the organism. Examples: spinal cord, vertebrae, muscles of back. RBO_relaxed.owl UBERON:0005178 biolink:NamedThing thoracic cavity element An organ or element that is in the thoracic cavity. Examples: lung, heart, longus colli. RBO_relaxed.owl UBERON:0005179 biolink:NamedThing pelvic region element An organ or element that is part of the pelvic region. Examples: reproductive organs (in some organisms), urinary bladder, bones of the pelvis. RBO_relaxed.owl UBERON:0013765 biolink:NamedThing digestive system element Any of the organs or elements that are part of the digestive system. Examples: tongue, esophagus, spleen, crop, lunge feeding organ, tooth elements. RBO_relaxed.owl UBERON:0004111 biolink:NamedThing anatomical conduit Any tube, opening or passage that connects two distinct anatomical spaces. RBO_relaxed.owl UBERON:0000055 biolink:NamedThing vessel A tubular structure that contains, conveys body fluid, such as blood or lymph. RBO_relaxed.owl UBERON:0000161 biolink:NamedThing orifice Anatomical conduit that connects two adjacent body spaces (or a body space with the space surrounding the organism)[FMA,modified]. RBO_relaxed.owl UBERON:0001005 biolink:NamedThing respiratory airway An airway through which respiratory air passes in organisms. RBO_relaxed.owl UBERON:0001131 biolink:NamedThing vertebral foramen A foramen within a vertebral element through which the spinal cord runs. It is formed by the anterior segment, and the posterior part, the vertebral arch. RBO_relaxed.owl UBERON:0005744 biolink:NamedThing bone foramen Anatomical space that is an opening in a bone, usually for passage of blood vessels or nerves. RBO_relaxed.owl UBERON:0006692 biolink:NamedThing vertebral canal A conduit enclosed within the vertebral foramen of the vertebrae through which the spinal cord passes. RBO_relaxed.owl UBERON:0000475 biolink:NamedThing organism subdivision Anatomical structure which is a subdivision of a whole organism, consisting of components of multiple anatomical systems, largely surrounded by a contiguous region of integument. RBO_relaxed.owl UBERON:0000153 biolink:NamedThing anterior region of body RBO_relaxed.owl UBERON:0000154 biolink:NamedThing posterior region of body RBO_relaxed.owl UBERON:0000974 biolink:NamedThing neck An organism subdivision that extends from the head to the pectoral girdle, encompassing the cervical vertebral column. RBO_relaxed.owl UBERON:0001137 biolink:NamedThing dorsum A major subdivision of an organism that is the entire part of the organism dorsal to a horizontal plane and bounded on one side by the same transverse plane. In vertebrares this includes the vertebral column.. RBO_relaxed.owl UBERON:0001444 biolink:NamedThing subdivision of head RBO_relaxed.owl UBERON:0007811 biolink:NamedThing craniocervical region The anteriormost subdivision of the body that includes the head, jaws, pharyngeal region and the neck (if present). In vertebrates this is the subdivision that includes the cervical vertebrae. RBO_relaxed.owl UBERON:0007823 biolink:NamedThing appendage girdle region An organism subdivision that encompasses the region containing the pectoral or pelvic girdle. Note that this includes both the skeletal elements and associated tissues (integument, muscle, etc). RBO_relaxed.owl UBERON:0008231 biolink:NamedThing dorsal thoracic segment of trunk Subdivision of thorax, which in humans is the posterior part of the thorax and is demarcated from the chest by the external surface of the posterolateral part of the rib cage and the anterior surface of the thoracic vertebral column; together with the chest, it constitutes the thorax. RBO_relaxed.owl UBERON:0009569 biolink:NamedThing subdivision of trunk RBO_relaxed.owl UBERON:0011676 biolink:NamedThing subdivision of organism along main body axis A major subdivision of an organism that divides an organism along its main body axis (typically anterio-posterior axis). In vertebrates, this is based on the vertebral column. RBO_relaxed.owl UBERON:0013701 biolink:NamedThing main body axis A principle subdivision of an organism that includes all structures along the primary axis, typically the anterior-posterior axis, from head to tail, including structures of the body proper where present (for example, ribs), but excluding appendages. RBO_relaxed.owl UBERON:0013702 biolink:NamedThing body proper The region of the organism associated with the visceral organs. RBO_relaxed.owl UBERON:0000031 biolink:NamedThing lamina propria of trachea A lamina propria that is part of a respiratory airway. RBO_relaxed.owl UBERON:0001974 biolink:NamedThing lamina propria of esophagus A lamina propria that is part of a esophagus [Automatically generated definition]. RBO_relaxed.owl UBERON:0004779 biolink:NamedThing respiratory system lamina propria A lamina propria that is part of a respiratory system [Automatically generated definition]. RBO_relaxed.owl UBERON:0004780 biolink:NamedThing gastrointestinal system lamina propria A lamina propria that is part of a gastrointestinal system. RBO_relaxed.owl UBERON:0005334 biolink:NamedThing oral lamina propria A lamina propria that is part of a mucosa of oral region. RBO_relaxed.owl UBERON:0015834 biolink:NamedThing duodenum lamina propria A lamina propria that is part of a duodenum. RBO_relaxed.owl UBERON:0000033 biolink:NamedThing head The head is the anterior-most division of the body [GO]. RBO_relaxed.owl UBERON:0000915 biolink:NamedThing thoracic segment of trunk Subdivision of trunk that lies between the head and the abdomen. RBO_relaxed.owl UBERON:0002100 biolink:NamedThing trunk Organism subdivision which is the part of the body posterior to the cervical region (or head, when cervical region not present) and anterior to the caudal region. Includes the sacrum when present. RBO_relaxed.owl UBERON:0002415 biolink:NamedThing tail An external caudal extension of the body. In chordates, the tail is post-anal, in other animals the anus ends in the tail. RBO_relaxed.owl UBERON:0002417 biolink:NamedThing abdominal segment of trunk The abdominal segment of the torso. RBO_relaxed.owl UBERON:0005434 biolink:NamedThing cervical region RBO_relaxed.owl UBERON:0006071 biolink:NamedThing caudal region Subdivision of an organism along anterior-posterior axis that is the posteriormost region, extending past the anus (or cloaca, if present), consisting of a tail in some fully formed chordates (or a tail bud in embryos). In animals that have a sacral region, this is the region immediately posterior to this. RBO_relaxed.owl UBERON:0010162 biolink:NamedThing post-anal tail tip The distal end of the tail. RBO_relaxed.owl UBERON:0000481 biolink:NamedThing multi-tissue structure Anatomical structure that has as its parts two or more portions of tissue of at least two different types and which through specific morphogenetic processes forms a single distinct structural unit demarcated by bona-fide boundaries from other distinct structural units of different types. RBO_relaxed.owl UBERON:0000073 biolink:NamedThing regional part of nervous system Any part or collection of parts of the central or peripheral nervous system. Parts may span both CNS and PNS. RBO_relaxed.owl UBERON:0007375 biolink:NamedThing roof of mouth A multi-tissue structure consisting of bone and soft tissue that forms a part of the roof of the oral cavity. In mammals this is the combination of the primary palate (premaxilla) and the secondary palate. In early tetrapods it consists of the vomer, pterygoid, parasphenoid, palatine and ectopterygoid bones. RBO_relaxed.owl UBERON:0009191 biolink:NamedThing sphenoid bone pre-cartilage condensation A sphenoid endochondral element that is composed primarily of a pre-cartilage condensation. RBO_relaxed.owl UBERON:0011997 biolink:NamedThing coelom The aggregate of the coelemic cavity lumen plus the membranes that line the lumen. RBO_relaxed.owl UBERON:0012361 biolink:NamedThing internal anal region RBO_relaxed.owl UBERON:0012469 biolink:NamedThing external anal region RBO_relaxed.owl UBERON:0016887 biolink:NamedThing entire extraembryonic component The part of the conceptus that may be lost before birth or will be discarded at birth, or when the embryo becomes an independent organism. RBO_relaxed.owl UBERON:0000063 biolink:NamedThing organ subunit A part of an organ that constitutes a distinct modular sub-unit. In some cases, the organ may also contain other sub-units of identical or similar types, in other cases this may be a distinct entity. RBO_relaxed.owl UBERON:0004732 biolink:NamedThing segmental subdivision of nervous system Any segmental subdivision of a nervous system. Includes metameric developmental segments, such as vertebrates neuromeres. RBO_relaxed.owl UBERON:0009911 biolink:NamedThing lobule RBO_relaxed.owl UBERON:0009912 biolink:NamedThing anatomical lobe A portion of an organ, such as the liver, lung, breast, or brain. RBO_relaxed.owl UBERON:0014765 biolink:NamedThing crus of diaphragm The domain of the diaphragm that is located dorsally and attaches to the vertebrae and surrounds the esophagus and aorta. RBO_relaxed.owl UBERON:0004921 biolink:NamedThing subdivision of digestive tract A proximal-distal subdivision of the digestive tract. RBO_relaxed.owl UBERON:0000168 biolink:NamedThing proximal-distal subdivision of colon A section dividing a colon along a proximal-distal axis. RBO_relaxed.owl UBERON:0006562 biolink:NamedThing pharynx The pharynx is the part of the digestive system immediately posterior to the mouth[GO]. RBO_relaxed.owl UBERON:0009854 biolink:NamedThing digestive tract diverticulum Branch or outpocketing of the digestive tract. RBO_relaxed.owl UBERON:0003408 biolink:NamedThing gland of digestive tract A gland that is part of a digestive tract [Automatically generated definition]. RBO_relaxed.owl UBERON:0003832 biolink:NamedThing esophagus muscle Any muscle organ that is part of a esophagus [Automatically generated definition]. RBO_relaxed.owl UBERON:0006925 biolink:NamedThing digestive system gland Any gland that is part of the digestive system. RBO_relaxed.owl UBERON:0010039 biolink:NamedThing food storage organ An organ of the digestive tract that is capable of retaining and storing food. RBO_relaxed.owl UBERON:0011185 biolink:NamedThing gastrointestinal sphincter A sphincter muscle that is part of the gastrointestinal system. RBO_relaxed.owl UBERON:0012360 biolink:NamedThing bone of jaw A bone element that is part of a jaw region. RBO_relaxed.owl UBERON:0014783 biolink:NamedThing cloacal muscle Any muscle organ that is part of a cloaca. RBO_relaxed.owl UBERON:0000060 biolink:NamedThing anatomical wall Organ component adjacent to an organ cavity and which consists of a maximal aggregate of organ component layers. RBO_relaxed.owl UBERON:0000064 biolink:NamedThing organ part A multicellular structure that is a part of an organ. RBO_relaxed.owl UBERON:0000353 biolink:NamedThing parenchyma Functional part of an organ in the body. This is in contrast to the stroma, which refers to the structural tissue of organs, being exactly, connective tissues. RBO_relaxed.owl UBERON:0000440 biolink:NamedThing trabecula A small, often microscopic, tissue element in the form of a small beam, strut or rod, generally having a mechanical function, and usually but not necessarily composed of dense collagenous tissue. On histological section, a trabecula can look like a septum, but in three dimensions they are topologically distinct, with trabeculae being roughly rod or pillar-shaped and septa being sheet-like. Trabeculae are usually composed of dense fibrous tissue, i.e. mainly of collagen, and in most cases provide mechanical strengthening or stiffening to a soft solid organ, such as the spleen. They can be composed of other materials, such as bone or muscle[WP]. RBO_relaxed.owl UBERON:0003891 biolink:NamedThing stroma Connective, non-functional supportive framework of a biological cell, tissue, or organ. Contrast with parenchyma. RBO_relaxed.owl UBERON:0006003 biolink:NamedThing integumentary adnexa Anatomical structure embedded in or located in the integument that is part of the integumental system. Examples: hair, follicles, skin glands, claws, nails, feathers. RBO_relaxed.owl UBERON:0013522 biolink:NamedThing subdivision of tube RBO_relaxed.owl UBERON:0000463 biolink:NamedThing organism substance Material anatomical entity in a gaseous, liquid, semisolid or solid state; produced by anatomical structures or derived from inhaled and ingested substances that have been modified by anatomical structures as they pass through the body. RBO_relaxed.owl UBERON:0005423 biolink:NamedThing developing anatomical structure RBO_relaxed.owl UBERON:0034923 biolink:NamedThing disconnected anatomical group Material anatomical entity consisting of multiple anatomical structures that are not connected to each other. RBO_relaxed.owl UBERON:0034925 biolink:NamedThing anatomical collection A collection of anatomical structures that are alike in terms of their morphology or developmental origin. RBO_relaxed.owl UBERON:0036215 biolink:NamedThing anatomical surface region Material anatomical entity that forms the outermost boundary of an anatomical structure. RBO_relaxed.owl UBERON:0005156 biolink:NamedThing reproductive structure Any anatomical structure that is part of the reproductive system. RBO_relaxed.owl UBERON:0034921 biolink:NamedThing multi organ part structure An multicellular anatomical structure that has subparts of multiple organs as a part. RBO_relaxed.owl UBERON:0000066 biolink:NamedThing fully formed stage The stage of development at which the animal is fully formed, including immaturity and maturity. Includes both sexually immature stage, and adult stage. RBO_relaxed.owl UBERON:0000069 biolink:NamedThing larval stage A distinct juvenile stage many animals undergo before metamorphosis into adults. Animals with indirect development such as insects, amphibians, or cnidarians typically have a larval phase of their life cycle. RBO_relaxed.owl UBERON:0000071 biolink:NamedThing death stage End of the life of an organism. RBO_relaxed.owl UBERON:0000092 biolink:NamedThing post-embryonic stage Stage succeeding embryo, including mature structure. RBO_relaxed.owl UBERON:0000106 biolink:NamedThing zygote stage A stage at which the organism is a single cell produced by means of sexual reproduction. RBO_relaxed.owl UBERON:0000107 biolink:NamedThing cleavage stage The first few specialized divisions of an activated animal egg; Stage consisting of division of cells in the early embryo. The zygotes of many species undergo rapid cell cycles with no significant growth, producing a cluster of cells the same size as the original zygote. The different cells derived from cleavage are called blastomeres and form a compact mass called the morula. Cleavage ends with the formation of the blastula. RBO_relaxed.owl UBERON:0000108 biolink:NamedThing blastula stage An early stage of embryonic development in animals. It is produced by cleavage of a fertilized ovum and consists of a spherical layer of around 128 cells surrounding a central fluid-filled cavity called the blastocoel. The blastula follows the morula and precedes the gastrula in the developmental sequence. RBO_relaxed.owl UBERON:0000109 biolink:NamedThing gastrula stage A stage defined by complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. The details of gastrulation vary from species to species, but usually result in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm. RBO_relaxed.owl UBERON:0000110 biolink:NamedThing neurula stage Staged defined by the formation of a tube from the flat layer of ectodermal cells known as the neural plate. This will give rise to the central nervous system. RBO_relaxed.owl UBERON:0000111 biolink:NamedThing organogenesis stage A stage at which the ectoderm, endoderm, and mesoderm develop into the internal organs of the organism. RBO_relaxed.owl UBERON:0000930 biolink:NamedThing stomodeum Anterior part of the embryonic digestive tract that develops into a mouth. The stomodeum includes as parts an invagination of the ectoderm and the stomodeal cavity. RBO_relaxed.owl UBERON:0006834 biolink:NamedThing uterus or analog A subdivision of a the reproductive tract in a female organism that is the site of embryo development. RBO_relaxed.owl UBERON:0000076 biolink:NamedThing external ectoderm The surface (external) layer of ectoderm which begins to proliferate shortly after separation from the neuroectoderm. RBO_relaxed.owl UBERON:0000490 biolink:NamedThing unilaminar epithelium Epithelium which consists of a single layer of epithelial cells. Examples: endothelium, mesothelium, glandular squamous epithelium.[FMA]. RBO_relaxed.owl UBERON:0000484 biolink:NamedThing simple cuboidal epithelium Unilaminar epithelium that consists of a single layer of cuboidal cells. RBO_relaxed.owl UBERON:0000485 biolink:NamedThing simple columnar epithelium Unilaminar epithelium, which consists of a single layer of columnar cells. Examples: ciliated columnar epithelium, gastric epithelium, microvillus columnar epithelium.[FMA]. RBO_relaxed.owl UBERON:0000487 biolink:NamedThing simple squamous epithelium Unilaminar epithelium which consists of a single layer of squamous cells. Examples: pulmonary alveolar epithelium, endothelium.[FMA]. RBO_relaxed.owl UBERON:0003071 biolink:NamedThing eye primordium Portion of tissue that is part of the anterior neural keel and will form the optic vesicle[ZFA]. A paired ectodermal placode that becomes invaginated to form the embryonic lens vesicles. RBO_relaxed.owl UBERON:0003258 biolink:NamedThing endoderm of foregut An endoderm that is part of a foregut [Automatically generated definition]. RBO_relaxed.owl UBERON:0003259 biolink:NamedThing endoderm of midgut An endoderm that is part of a midgut [Automatically generated definition]. RBO_relaxed.owl UBERON:0003260 biolink:NamedThing endoderm of hindgut An endoderm that is part of a hindgut [Automatically generated definition]. RBO_relaxed.owl UBERON:0003371 biolink:NamedThing pelvic appendage bud ectoderm An unilaminar epithelium that surrounds a pelvic appendage bud. RBO_relaxed.owl UBERON:0003372 biolink:NamedThing pectoral appendage bud ectoderm An unilaminar epithelium that surrounds a pectoral appendage bud. RBO_relaxed.owl UBERON:0006267 biolink:NamedThing notochordal plate The notochordal plate is the dorsal part of the notochordal process when the ventral portion breaks down. It is continuous laterally with the endoderm that composes the roof of the primitive foregut and is in contact dorsally with the neural tube. The folding off of the notochordal plate gives rise to the notochord. RBO_relaxed.owl UBERON:0007383 biolink:NamedThing enveloping layer of ectoderm Outermost layer of cells surrounding the embryo. RBO_relaxed.owl UBERON:0009497 biolink:NamedThing epithelium of foregut-midgut junction An epithelium that is part of a foregut-midgut junction. RBO_relaxed.owl UBERON:0009521 biolink:NamedThing anal membrane endodermal component An endoderm that is part of a anal region. RBO_relaxed.owl UBERON:0011272 biolink:NamedThing embryonic skin basal layer RBO_relaxed.owl UBERON:0011642 biolink:NamedThing oral epithelium from ectoderm An epithelium that develops_from a ectoderm and is part of a oral epithelium. RBO_relaxed.owl UBERON:0014702 biolink:NamedThing frontonasal process epithelium An epithelium that is part of a frontonasal prominence. RBO_relaxed.owl UBERON:0014703 biolink:NamedThing anal membrane ectodermal component A unilaminar epithelium that develops_from a ectoderm and is part of a anal region. RBO_relaxed.owl UBERON:0016545 biolink:NamedThing pharyngeal ectoderm The external part of the developing pharynx that is made of ectoderm. During vertebrate development, pockets form in pharyngeal ectoderm between the pharyngeal arches. RBO_relaxed.owl UBERON:0005291 biolink:NamedThing embryonic tissue A portion of tissue that is part of an embryo. RBO_relaxed.owl UBERON:0003304 biolink:NamedThing mesoderm blood island A blood island that is part of a mesoderm. RBO_relaxed.owl UBERON:0003894 biolink:NamedThing liver primordium A small endodermal thickening in the foregut adjacent to the transverse septum. Invaginates forming the hepatic diverticulum. RBO_relaxed.owl UBERON:0003922 biolink:NamedThing pancreatic epithelial bud The embryonic pancreas develops from two separate anlagen in the foregut epithelium, one dorsal and two ventral pancreatic buds[PMID]. RBO_relaxed.owl UBERON:0004022 biolink:NamedThing germinal neuroepithelium The single layer of epithelial cells that lines the early neural tube and develops into the nervous system and into the neural crest cells. RBO_relaxed.owl UBERON:0004060 biolink:NamedThing neural tube ventricular layer The layer of undifferentiated, proliferating cells that line the neural tube lumen that is the immediate transformation of the germinal neuroepithelium. RBO_relaxed.owl UBERON:0004061 biolink:NamedThing neural tube mantle layer The layer of glia and differentiating neurons that forms as a second layer around the germinal neuroepithium; as this develops it comes to lie between the ventricular and marginal layers and includes the basal and alar plates. Develops into neurons and glia forming a gray matter layer. RBO_relaxed.owl UBERON:0005253 biolink:NamedThing head mesenchyme Portion of primordial embryonic connective tissue of the developing head, consisting of mesenchymal cells supported in interlaminar jelly, that derive mostly from the mesoderm and contribute to head connective tissue, bone and musculature in conjunction with cranial neural crest cells. RBO_relaxed.owl UBERON:0005256 biolink:NamedThing trunk mesenchyme Mesenchyme that is part of a developing trunk. RBO_relaxed.owl UBERON:0005594 biolink:NamedThing head somite Somite located in the head region, caudal to the otic vesicle. RBO_relaxed.owl UBERON:0005702 biolink:NamedThing optic eminence mesenchyme Mesenchyme that is part of a optic eminence. RBO_relaxed.owl UBERON:0005866 biolink:NamedThing pre-cartilage condensation A delimited region of dense mesenchyme within looser mesenchyme whose cells are committed to become chondroblasts. RBO_relaxed.owl UBERON:0006239 biolink:NamedThing future central tendon A tendon that has the potential to develop into a central tendon. RBO_relaxed.owl UBERON:0006279 biolink:NamedThing pleuroperitoneal canal Each of the canals that links the peritoneal cavity and the caudal part of a pleural cavity. RBO_relaxed.owl UBERON:0007690 biolink:NamedThing early pharyngeal endoderm RBO_relaxed.owl UBERON:0008835 biolink:NamedThing hepatic diverticulum An out-pocket of thickened ventral foregut epithelium adjacent to the developing heart. Constitutes the first morphological sign of the embryonic liver. The anterior portion of the hepatic diverticulum gives rise to the liver and intrahepatic biliary tree, while the posterior portion forms the gall bladder and extrahepatic bile ducts. RBO_relaxed.owl UBERON:0009129 biolink:NamedThing right atrium endocardium Endocardium that is part of the right atrium. RBO_relaxed.owl UBERON:0009133 biolink:NamedThing pleuroperitoneal membrane A fold of tissue which extends into the peritoneal cavity of the developing embryo and participates in the separation of the pleural and peritoneal cavities. RBO_relaxed.owl UBERON:0009526 biolink:NamedThing maxillary process mesenchyme Mesenchyme that is part of a maxillary prominence. RBO_relaxed.owl UBERON:0009722 biolink:NamedThing entire pharyngeal arch endoderm RBO_relaxed.owl UBERON:0009846 biolink:NamedThing embryonic cloacal epithelium An epithelium that is part of a embryonic cloaca. RBO_relaxed.owl UBERON:0010046 biolink:NamedThing entire pharyngeal arch associated mesenchyme The sum total of mesenchymal tissue in the pharyngeal arch region. Pharyngeal mesenchyme is undifferentiated, loose connective tissue derived mostly from mesoderm, and also contains ectodermally derived neural crest cells. RBO_relaxed.owl UBERON:0010359 biolink:NamedThing pharyngeal arch mesenchyme from neural crest Mesenchyme that develops_from a neural crest and is part of a entire pharyngeal arch associated mesenchyme. RBO_relaxed.owl UBERON:0000085 biolink:NamedThing morula A spherical embryonic mass of blastomeres formed before the blastula and resulting from cleavage of the fertilized ovum. RBO_relaxed.owl UBERON:0007010 biolink:NamedThing cleaving embryo Organism at the cleavage stage. RBO_relaxed.owl UBERON:0005764 biolink:NamedThing acellular membrane An acellular anatomical structure that is the bounding layer of a anatomical structure. RBO_relaxed.owl UBERON:0002050 biolink:NamedThing embryonic structure Anatomical structure that is part of an embryo. RBO_relaxed.owl UBERON:0002061 biolink:NamedThing truncus arteriosus The truncus arteriosus and bulbus cordis are divided by the aorticopulmonary septum. The truncus arteriosus gives rise to the ascending aorta and the pulmonary trunk. The bulbus cordis gives rise to the smooth parts (outflow tract) of the left and right ventricles. RBO_relaxed.owl UBERON:0002532 biolink:NamedThing epiblast (generic) In amniote animal embryology, the epiblast is a tissue type derived either from the inner cell mass in mammals or the blastodisc in birds and reptiles. It lies above the hypoblast. In mammalian embryogenesis, the columnar cells of the epiblast are adjacent to the trophoblast, while the cuboidal cells of the hypoblast are closer to the blastocoele. The epiblast, whilst referred to as the primary ectoderm, differentiates to form all three layers of the trilaminar germ disc in a process called gastrulation[WP]. The outer of the two layers of the blastoderm that form during gastrulation, corresponding to primitive ectoderm during gastrulation and to the definitive ectoderm after gastrulation[ZFA]. RBO_relaxed.owl UBERON:0002533 biolink:NamedThing post-anal tail bud The rapidly proliferating mass of cells at the caudal extremity of the embryo; remnant of the primitive node. RBO_relaxed.owl UBERON:0003057 biolink:NamedThing chordal neural plate The portion of neural plate posterior to the mid-hindbrain junction. RBO_relaxed.owl UBERON:0004356 biolink:NamedThing apical ectodermal ridge Multilayered ectodermal region at the distal tip of a limb or fin bud necessary for the proper development of the underlying mesenchyme[MP,modified]. Along with the zone of polarizing activity, it is a crucial organizing region during limb development[WP]. RBO_relaxed.owl UBERON:0004364 biolink:NamedThing ectoplacental cone Thickened trophoblast of the blastocyst in rodents that becomes the fetal portion of the placenta. RBO_relaxed.owl UBERON:0004706 biolink:NamedThing bulbus cordis A transient fetal dilation of the distal (or cranial) heart tube located where the arterial trunk joins the ventral roots of the aortic arches. RBO_relaxed.owl UBERON:0004872 biolink:NamedThing splanchnic layer of lateral plate mesoderm Layer of lateral plate mesoderm that forms the circulatory system and future gut wall - overlies endoderm[WP]. RBO_relaxed.owl UBERON:0004873 biolink:NamedThing splanchnopleure A structure created during embryogenesis when the lateral mesoderm splits into two layers - the inner (or splanchnic) layer adheres to the endoderm, and with it forms the splanchnopleure[WP]. RBO_relaxed.owl UBERON:0004874 biolink:NamedThing somatopleure A structure created during embryogenesis when the lateral mesoderm splits into two layers - the outer (or somatic) layer becomes applied to the inner surface of the ectoderm, and with it forms the somatopleure.[WP]. RBO_relaxed.owl UBERON:0004880 biolink:NamedThing chordamesoderm The central region of trunk mesoderm. This tissue forms the notochord. RBO_relaxed.owl UBERON:0005061 biolink:NamedThing neural groove The median dorsal longitudinal groove formed in the embryo by the neural plate after the appearance of the neural folds. RBO_relaxed.owl UBERON:0005085 biolink:NamedThing ectodermal placode An ectodermal placode is a thickening of the ectoderm that is the primordium of many structures derived from the ectoderm[GO]. RBO_relaxed.owl UBERON:0005092 biolink:NamedThing right horn of sinus venosus RBO_relaxed.owl UBERON:0005432 biolink:NamedThing aortic sac The dilated structure that is lined by endothelial cells and located at the arterial pole of the heart just above (distal to) the truncus arteriosus in mammalian embryos; it is the primordial vascular channel from which the aortic arches (and eventually the dorsal aortae) arise; the aortic sac is homologous to the ventral aorta of gill-bearing vertebrates. RBO_relaxed.owl UBERON:0006218 biolink:NamedThing common atrial chamber RBO_relaxed.owl UBERON:0007237 biolink:NamedThing 1st arch mandibular component RBO_relaxed.owl UBERON:0007238 biolink:NamedThing 1st arch maxillary component RBO_relaxed.owl UBERON:0012314 biolink:NamedThing embryonic facial prominence One of five swellings formed during the development of the face. RBO_relaxed.owl UBERON:0002200 biolink:NamedThing vasculature of head Vasculature that is part of a head [Automatically generated definition]. RBO_relaxed.owl UBERON:0002201 biolink:NamedThing vasculature of trunk A vasculature that is part of a trunk [Automatically generated definition]. RBO_relaxed.owl UBERON:0004118 biolink:NamedThing vasculature of iris A vasculature that is part of a iris [Automatically generated definition]. RBO_relaxed.owl UBERON:0004374 biolink:NamedThing vitelline vasculature Vascular network that is connected to the yolk sac. RBO_relaxed.owl UBERON:0004521 biolink:NamedThing vasculature of muscle organ A vasculature that is part of a muscle organ [Automatically generated definition]. RBO_relaxed.owl UBERON:0004522 biolink:NamedThing vasculature of musculoskeletal system A vasculature that is part of a musculoskeletal system [Automatically generated definition]. RBO_relaxed.owl UBERON:0004581 biolink:NamedThing systemic venous system The part of the venous system that drains the general body tissues[Kardong]. RBO_relaxed.owl UBERON:0004864 biolink:NamedThing vasculature of retina A vasculature that is part of a retina [Automatically generated definition]. RBO_relaxed.owl UBERON:0005806 biolink:NamedThing portal system In the circulatory system of animals, a portal venous system occurs when a capillary bed drains into another capillary bed through veins, without first going through the heart. Both capillary beds and the blood vessels that connect them are considered part of the portal venous system. They are relatively uncommon as the majority of capillary beds drain into veins which then drain into the heart, not into another capillary bed. Portal venous systems are considered venous because the blood vessels that join the two capillary beds are either veins or venules. Examples of such systems include the hepatic portal system and the hypophyseal portal system. Unqualified, 'portal venous system' often refers to the hepatic portal system. For this reason, 'portal vein' most commonly refers to the hepatic portal vein[WP]. RBO_relaxed.owl UBERON:0006876 biolink:NamedThing vasculature of organ A vasculature that is part of a organ. RBO_relaxed.owl UBERON:0006877 biolink:NamedThing vasculature of liver A vasculature that is part of a liver. RBO_relaxed.owl UBERON:0007204 biolink:NamedThing brachiocephalic vasculature The vasculature consisting of brachiocephalic arteries and veins. RBO_relaxed.owl UBERON:0007302 biolink:NamedThing pectoral appendage vasculature A vasculature that is part of a pectoral appendage. RBO_relaxed.owl UBERON:0007303 biolink:NamedThing pharyngeal vasculature A vasculature that is part of a chordate pharynx. RBO_relaxed.owl UBERON:0007304 biolink:NamedThing appendage vasculature A vasculature that is part of a limb/fin. RBO_relaxed.owl UBERON:0010204 biolink:NamedThing tail vasculature A vasculature that is part of a post-anal tail. RBO_relaxed.owl UBERON:0013127 biolink:NamedThing pulmonary venous system The part of the venous system that drains the lungs[Kardong]. RBO_relaxed.owl UBERON:0018674 biolink:NamedThing heart vasculature An interconnected tubular multi-tissue structure that contains fluid that is actively transported around the heart. RBO_relaxed.owl UBERON:0035549 biolink:NamedThing vasculature of integument The part of the circulatory system that lies within the subcutaneous tissue layers close to the surface of the skin. RBO_relaxed.owl UBERON:0035551 biolink:NamedThing deep vasculature The part of the circulatory system that lies deep beneath the subcutaneous tissue layers away from the surface of the skin. RBO_relaxed.owl UBERON:0036301 biolink:NamedThing vasculature of spleen RBO_relaxed.owl UBERON:0036302 biolink:NamedThing vasculature of central nervous system plus retina RBO_relaxed.owl UBERON:0036303 biolink:NamedThing vasculature of central nervous system RBO_relaxed.owl UBERON:2001073 biolink:NamedThing axial vasculature RBO_relaxed.owl UBERON:0003567 biolink:NamedThing abdomen connective tissue A portion of connective tissue that is part of an abdomen [Automatically generated definition]. RBO_relaxed.owl UBERON:0003568 biolink:NamedThing neck connective tissue A portion of connective tissue that is part of a neck [Automatically generated definition]. RBO_relaxed.owl UBERON:0003570 biolink:NamedThing respiratory system connective tissue A portion of connective tissue that is part of a respiratory system [Automatically generated definition]. RBO_relaxed.owl UBERON:0003586 biolink:NamedThing trunk connective tissue A portion of connective tissue that is part of a trunk [Automatically generated definition]. RBO_relaxed.owl UBERON:0003593 biolink:NamedThing thoracic cavity connective tissue A portion of connective tissue that is part of a thoracic cavity [Automatically generated definition]. RBO_relaxed.owl UBERON:0003594 biolink:NamedThing pelvis connective tissue A portion of connective tissue that is part of a pelvis [Automatically generated definition]. RBO_relaxed.owl UBERON:0003599 biolink:NamedThing tail connective tissue A portion of connective tissue that is part of a tail [Automatically generated definition]. RBO_relaxed.owl UBERON:0003837 biolink:NamedThing thoracic segment connective tissue A portion of connective tissue that is part of a thorax [Automatically generated definition]. RBO_relaxed.owl UBERON:0003838 biolink:NamedThing abdominal segment connective tissue A portion of connective tissue that is part of an abdominal segment of trunk [Automatically generated definition]. RBO_relaxed.owl UBERON:0004267 biolink:NamedThing back connective tissue A portion of connective tissue that is part of a back [Automatically generated definition]. RBO_relaxed.owl UBERON:0004857 biolink:NamedThing skeletal muscle connective tissue A connective tissue that surrounds a skeletal muscle tissue. RBO_relaxed.owl UBERON:0011821 biolink:NamedThing irregular connective tissue Connective tissue, which consists of a population of connective tissue cells, the intercellular matrix of which contains an irregular network of collagen and elastic fiber bundles. Examples: areolar tissue, mucoid tissue, connective tissue of peritoneum, connective tissue of fibrous pericardium. RBO_relaxed.owl UBERON:0006670 biolink:NamedThing central tendon of diaphragm The three-lobed cloverleaf-shaped aponeurosis situated at the center of the diaphragm; the central tendon is fused with the fibrous pericardium that provides attachment for the muscle fibers. RBO_relaxed.owl UBERON:0000486 biolink:NamedThing multilaminar epithelium Epithelium which consists of more than one layer of epithelial cells that may or may not be in contact with a basement membrane. Examples: keratinized stratified squamous epithelium, ciliated stratified columnar epithelium.[FMA]. RBO_relaxed.owl UBERON:0000488 biolink:NamedThing atypical epithelium Epithelium that consists of epithelial cells not arranged in one ore more layers. RBO_relaxed.owl UBERON:0001276 biolink:NamedThing epithelium of stomach The epithelial layer of the stomach . RBO_relaxed.owl UBERON:0001278 biolink:NamedThing epithelium of large intestine An epithelium that is part of a large intestine [Automatically generated definition]. RBO_relaxed.owl UBERON:0001778 biolink:NamedThing ciliary epithelium A double layer covering the ciliary body that produces aqueous humor. RBO_relaxed.owl UBERON:0002506 biolink:NamedThing iris epithelium An epithelium that is part of a iris [Automatically generated definition]. RBO_relaxed.owl UBERON:0003235 biolink:NamedThing epithelium of upper jaw An epithelium that is part of a upper jaw [Automatically generated definition]. RBO_relaxed.owl UBERON:0003236 biolink:NamedThing epithelium of lower jaw An epithelium that is part of a lower jaw [Automatically generated definition]. RBO_relaxed.owl UBERON:0003257 biolink:NamedThing yolk sac endoderm The portion of the yolk sac that is derived from endoderm and lines the yolk sac. RBO_relaxed.owl UBERON:0003350 biolink:NamedThing epithelium of mucosa A layer of epithelial cells on the surface of the mucosa. RBO_relaxed.owl UBERON:0003351 biolink:NamedThing pharyngeal epithelium An epithelium that is part of a pharynx [Automatically generated definition]. RBO_relaxed.owl UBERON:0003352 biolink:NamedThing epithelium of midgut An epithelium that is part of a midgut. RBO_relaxed.owl UBERON:0003353 biolink:NamedThing epithelium of hindgut An epithelium that is part of a hindgut [Automatically generated definition]. RBO_relaxed.owl UBERON:0003364 biolink:NamedThing epithelium of right lung An epithelium that is part of a right lung [Automatically generated definition]. RBO_relaxed.owl UBERON:0003365 biolink:NamedThing epithelium of left lung An epithelium that is part of a left lung [Automatically generated definition]. RBO_relaxed.owl UBERON:0003914 biolink:NamedThing epithelial tube Epithelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system. RBO_relaxed.owl UBERON:0003929 biolink:NamedThing digestive tract epithelium An epithelium that lines the lumen of the digestive tract. RBO_relaxed.owl UBERON:0004807 biolink:NamedThing respiratory system epithelium An epithelium that is part of a respiratory system [Automatically generated definition]. RBO_relaxed.owl UBERON:0004808 biolink:NamedThing gastrointestinal system epithelium An epithelium that is part of a digestive system [Automatically generated definition]. RBO_relaxed.owl UBERON:0004815 biolink:NamedThing lower respiratory tract epithelium An epithelium that is part of a lower respiratory tract [Automatically generated definition]. RBO_relaxed.owl UBERON:0004820 biolink:NamedThing bile duct epithelium Any epithelium that lines one of the bile ducts. RBO_relaxed.owl UBERON:0004909 biolink:NamedThing epithelium of gonad An epithelium surrounding a gonad. RBO_relaxed.owl UBERON:0004911 biolink:NamedThing epithelium of female gonad An epithelium surrounding an ovary. RBO_relaxed.owl UBERON:0005157 biolink:NamedThing epithelial fold An epithelial sheet bent on a linear axis. RBO_relaxed.owl UBERON:0005614 biolink:NamedThing lens anterior epithelium A layer of cuboidal epithelial cells bounded anteriorly by the capsule of the lens and posteriorly by the lens cortex. RBO_relaxed.owl UBERON:0005637 biolink:NamedThing pyloric region epithelium An epithelium that is part of a pylorus. RBO_relaxed.owl UBERON:0005638 biolink:NamedThing anterior chamber epithelium An epithelium that is part of a anterior chamber of eyeball. RBO_relaxed.owl UBERON:0005656 biolink:NamedThing lens vesicle epithelium An epithelium that is part of a lens vesicle. RBO_relaxed.owl UBERON:0006913 biolink:NamedThing lip epithelium An epithelium that is part of a lip. RBO_relaxed.owl UBERON:0006914 biolink:NamedThing squamous epithelium An epithelium characterised by its most superficial layer consisting of squamous epithelial cells. RBO_relaxed.owl UBERON:0006934 biolink:NamedThing sensory epithelium Simple columnar epithelium made up of cells specialized to serve as sensory cells for the reception of external stimuli, as the sensory cells of the cochlea, vestibule, nasal mucosa, and tongue. RBO_relaxed.owl UBERON:0007499 biolink:NamedThing epithelial sac An epithelial tube that is open at one end only. RBO_relaxed.owl UBERON:0007503 biolink:NamedThing epithelial vesicle A closed epithelium with a lumen. RBO_relaxed.owl UBERON:0007601 biolink:NamedThing ciliated epithelium Epithelium bearing vibratile cilia on the free surface. RBO_relaxed.owl UBERON:0007625 biolink:NamedThing pigment epithelium of eye Epithelial layer of the retina, ciliary body, or iris composed of cells containing pigment granules. RBO_relaxed.owl UBERON:0009970 biolink:NamedThing epithelium of pancreatic duct An epithelium that is part of a pancreatic duct. RBO_relaxed.owl UBERON:0010077 biolink:NamedThing cuboidal epithelium An epithelium consisting of cuboidal epithelial cells. RBO_relaxed.owl UBERON:0010303 biolink:NamedThing extraembryonic epithelium An epithelium that is part of a extraembryonic structure. RBO_relaxed.owl UBERON:0012274 biolink:NamedThing columnar epithelium An epithelium that consists of columnar epithelial cells. Columnar epithelia are epithelial cells whose heights are at least four times their width. Columnar epithelia are divided into simple (or unilayered), and the rarer stratified (or multi-layered).[WP, modified]. RBO_relaxed.owl UBERON:0012481 biolink:NamedThing cloacal epithelium An epithelium that is part of a cloaca. RBO_relaxed.owl UBERON:0013636 biolink:NamedThing epithelium of intestinal villus An epithelium that is part of a intestinal villus. RBO_relaxed.owl UBERON:0015179 biolink:NamedThing somite boundary epithelium Epithelium located in the intersomitic region. RBO_relaxed.owl UBERON:0015716 biolink:NamedThing anal canal epithelium An epithelium that is part of a anal canal. RBO_relaxed.owl UBERON:0015808 biolink:NamedThing eye epithelium An epithelium that is part of a camera-type eye. RBO_relaxed.owl UBERON:0015833 biolink:NamedThing foregut epithelium An epithelium that is part of a foregut. RBO_relaxed.owl UBERON:0016885 biolink:NamedThing epithelium of terminal part of digestive tract Epithelium lining the distalmost portion of the digestive tract. RBO_relaxed.owl UBERON:0019204 biolink:NamedThing skin epithelium Any region of epithelium that is part of a skin region. RBO_relaxed.owl UBERON:0019304 biolink:NamedThing sensory organ epithelium RBO_relaxed.owl UBERON:0034705 biolink:NamedThing developing neuroepithelium An embryonic or larval epithelium that is committed to form part of the nervous system. RBO_relaxed.owl UBERON:0034932 biolink:NamedThing epithelium of biliary system The epithelial layer covering the biliary system. This includes the epithelium of the gallbladder (when present) as well as the intrahepatic and extrahepatic bile ducts. RBO_relaxed.owl UBERON:0034969 biolink:NamedThing epithelial layer of duct RBO_relaxed.owl UBERON:0035037 biolink:NamedThing jaw epithelium RBO_relaxed.owl UBERON:0006555 biolink:NamedThing excretory tube A tube that is part of a excretory system. RBO_relaxed.owl UBERON:0000118 biolink:NamedThing lung bud Structure derived from foregut that becomes a lung[GO]. RBO_relaxed.owl UBERON:0005153 biolink:NamedThing epithelial bud A bud is a protrusion that forms from an epithelial sheet by localized folding. RBO_relaxed.owl UBERON:0010081 biolink:NamedThing future common hepatic duct An extrahepatic bile duct that has the potential to develop into a common hepatic duct. RBO_relaxed.owl UBERON:0036072 biolink:NamedThing respiratory primordium epithelium RBO_relaxed.owl UBERON:0000122 biolink:NamedThing neuron projection bundle A fasciculated bundle of neuron projections (GO:0043005), largely or completely lacking synapses. RBO_relaxed.owl UBERON:0012423 biolink:NamedThing layer of microvilli A layer of microvilli, Thin cylindrical membrane-covered projections on the surface of an animal cell containing a core bundle of actin filaments[GO,modified]. RBO_relaxed.owl UBERON:0022303 biolink:NamedThing nervous system cell part layer Single layer of a laminar structure, identified by different density, arrangement or size of cells and processes arranged in flattened layers or lamina[CUMBO]. RBO_relaxed.owl UBERON:0002020 biolink:NamedThing gray matter A nervous system structure composed primarily of nerve cell bodies (somas). May also include dendrites and the initial unmyelinated portion of axons. RBO_relaxed.owl UBERON:0016550 biolink:NamedThing spinal cord column RBO_relaxed.owl UBERON:0016570 biolink:NamedThing lamina of gray matter of spinal cord RBO_relaxed.owl UBERON:0034709 biolink:NamedThing hindbrain marginal layer RBO_relaxed.owl UBERON:0000126 biolink:NamedThing cranial nerve nucleus Nucleus that receives projections from or contains neurons that send projections through one of the cranial nerves. RBO_relaxed.owl UBERON:0002308 biolink:NamedThing nucleus of brain A neural nucleus that is part of the brain. RBO_relaxed.owl UBERON:0002925 biolink:NamedThing trigeminal nucleus A nucleus of brain that is part of a trigeminal nuclear complex. RBO_relaxed.owl UBERON:0006331 biolink:NamedThing brainstem nucleus A nucleus of brain that is part of a brainstem. RBO_relaxed.owl UBERON:0009661 biolink:NamedThing midbrain nucleus Nucleus located in the midbrain. RBO_relaxed.owl UBERON:0009662 biolink:NamedThing hindbrain nucleus Nucleus located within the hindbrain. RBO_relaxed.owl UBERON:0000166 biolink:NamedThing oral opening The orifice that connects the mouth to the exterior of the body. RBO_relaxed.owl UBERON:0012464 biolink:NamedThing cloacal vent The opening of the cloacal chamber to the outside of the organism. Birds maintain a single cloacal opening throughout their lives. RBO_relaxed.owl UBERON:0016458 biolink:NamedThing esophageal hiatus A hole in the diaphragm through which the esophagus passes. RBO_relaxed.owl UBERON:0036253 biolink:NamedThing orifice of skull RBO_relaxed.owl UBERON:0000167 biolink:NamedThing oral cavity Anatomical cavity at the start of the digestive tract that that is enclosed by the mouth. The boundaries and contents vary depending on the species. In vertebrates, the boundaries are the oral opening, the cheeks, the palate and (if present) the palatoglossal arch - if this is not present then the mouth and pharynx form the oropharyngeal cavity. The buccal cavity contains the teeth, tongue and palate (when present). RBO_relaxed.owl UBERON:0002224 biolink:NamedThing thoracic cavity The part of the coelemic cavity lumen that is enclosed by the walls of the thorax. RBO_relaxed.owl UBERON:0002553 biolink:NamedThing anatomical cavity Anatomical space which contains portions of one or more body substances and is bounded by the internal surface of one maximally connected anatomical structure. Examples: cranial cavity, pharyngeal recess space, nasal cavity, tooth socket, cavity of serous sac, lumen of stomach, lumen of artery, fornix of vagina. RBO_relaxed.owl UBERON:0003684 biolink:NamedThing abdominal cavity The part of the ventral body cavity that is within the abdomen proper (excluding the pelvic cavity). RBO_relaxed.owl UBERON:0003842 biolink:NamedThing neural tube lumen An anatomical space that surrounded_by a neural tube. RBO_relaxed.owl UBERON:0005082 biolink:NamedThing tube lumen A hole in a tube[GO]. RBO_relaxed.owl UBERON:0005688 biolink:NamedThing lens vesicle cavity An anatomical cavity that is part of a lens vesicle. RBO_relaxed.owl UBERON:0006909 biolink:NamedThing lumen of digestive tract An anatomical space that surrounded_by a digestive tract. RBO_relaxed.owl UBERON:0007147 biolink:NamedThing lumen of midgut An anatomical cavity that surrounded_by a midgut. RBO_relaxed.owl UBERON:0007148 biolink:NamedThing lumen of hindgut An anatomical cavity that surrounded_by a hindgut. RBO_relaxed.owl UBERON:0007158 biolink:NamedThing lumen of anal canal An anatomical cavity that surrounded_by a anal canal. RBO_relaxed.owl UBERON:0007159 biolink:NamedThing lumen of colon An anatomical cavity that surrounded_by a colon. RBO_relaxed.owl UBERON:0007473 biolink:NamedThing lumen of epithelial sac The space within an epithelial sphere. RBO_relaxed.owl UBERON:0008851 biolink:NamedThing ectoplacental cavity Closed space within the ectoplacental cone, formed by the fusion of the parts of the amniotic fold that separate it from the amniotic cavity[MP]. a developmental cavity that exists in some mammals and is derived by division of the proamniotic space; it is further removed from the embryo than the amniotic cavity in some mammals. RBO_relaxed.owl UBERON:0009669 biolink:NamedThing embryonic cloacal lumen An anatomical space that surrounded_by a embryonic cloaca. RBO_relaxed.owl UBERON:0009715 biolink:NamedThing stomodeal lumen An anatomical cavity that surrounded_by a stomodeum. RBO_relaxed.owl UBERON:0010161 biolink:NamedThing lumen of blood vessel An anatomical cavity that surrounded_by a blood vessel. RBO_relaxed.owl UBERON:0010276 biolink:NamedThing space in vertebral column Any anatomical space that is part of a vertebral column. RBO_relaxed.owl UBERON:0011566 biolink:NamedThing lumen of esophagus An anatomical cavity that is part of a esophagus. RBO_relaxed.owl UBERON:0011772 biolink:NamedThing lower jaw opening An anatomical space that is part of a bone of lower jaw. RBO_relaxed.owl UBERON:0011773 biolink:NamedThing upper jaw opening An anatomical space that is part of a bone of upper jaw. RBO_relaxed.owl UBERON:0012463 biolink:NamedThing cloacal lumen An anatomical space that is enclosed by a cloaca. RBO_relaxed.owl UBERON:0012465 biolink:NamedThing lumen of terminal part of digestive tract An anatomical space that is enclosed by a terminal part of digestive tract. RBO_relaxed.owl UBERON:0012466 biolink:NamedThing extraembryonic cavity RBO_relaxed.owl UBERON:0012467 biolink:NamedThing enclosed anatomical space An anatomical space with no opening to another space or to the exterior. RBO_relaxed.owl UBERON:0013514 biolink:NamedThing space surrounding organism The space that surrounds an organism. RBO_relaxed.owl UBERON:0013525 biolink:NamedThing stomach lumen The anatomical space that is enclosed by a stomach. RBO_relaxed.owl UBERON:0013686 biolink:NamedThing anatomical conduit space An anatomical space which is the lumen of some anatomical conduit and connects two or more spaces together[FMA,modified]. RBO_relaxed.owl UBERON:0014399 biolink:NamedThing sinusoidal space An anatomical space that is enclosed by a sinusoid. RBO_relaxed.owl UBERON:0016512 biolink:NamedThing lumen of duodenum An anatomical space that is part of a duodenum. RBO_relaxed.owl UBERON:0018543 biolink:NamedThing lumen of intestine The anatomical space within the intestine. RBO_relaxed.owl UBERON:0034905 biolink:NamedThing gland lumen RBO_relaxed.owl UBERON:0035819 biolink:NamedThing abdominopelvic cavity The part of the ventral body cavity that is within the abdominal segment of the trunk, which encompasses the abdomen proper plus pelvic cavity. RBO_relaxed.owl UBERON:0001074 biolink:NamedThing pericardial cavity A potential space between the visceral and parietal layers of the pericardium. RBO_relaxed.owl UBERON:0002558 biolink:NamedThing organ cavity RBO_relaxed.owl UBERON:0004867 biolink:NamedThing orbital cavity Anatomical cavity bounded by the orbital region of the cranium and forming the location of some or all of the eye. RBO_relaxed.owl UBERON:0005251 biolink:NamedThing yolk sac cavity An anatomical cavity that is part of a yolk sac [Automatically generated definition]. RBO_relaxed.owl UBERON:0007617 biolink:NamedThing synovial cavity of joint An anatomical cavity that surrounded_by a synovial joint. RBO_relaxed.owl UBERON:0008203 biolink:NamedThing pelvic cavity The part of the ventral body cavity that is within the pelvis. RBO_relaxed.owl UBERON:0011565 biolink:NamedThing lumen of gastrointestinal system RBO_relaxed.owl UBERON:0012054 biolink:NamedThing myocoele The cavity within a myotome. RBO_relaxed.owl UBERON:0013411 biolink:NamedThing cranial cavity Anatomical cavity that is the lumen of the skull and contains the brain. RBO_relaxed.owl UBERON:0016509 biolink:NamedThing cavity of right ventricle Luminal space of the right ventricle of the heart. RBO_relaxed.owl UBERON:0016513 biolink:NamedThing cavity of left atrium Luminal space of the left atrium of the heart. RBO_relaxed.owl UBERON:0016514 biolink:NamedThing cavity of left ventricle Luminal space of the left ventricle of the heart. RBO_relaxed.owl UBERON:0016522 biolink:NamedThing cavity of right atrium Luminal space of the right atrium of the heart. RBO_relaxed.owl UBERON:0035763 biolink:NamedThing cavity of cardiac chamber RBO_relaxed.owl UBERON:0035809 biolink:NamedThing serous cavity RBO_relaxed.owl UBERON:0004288 biolink:NamedThing skeleton Anatomical cluster that consists of all the skeletal elements (eg., bone, cartilage, and teeth) of the body. RBO_relaxed.owl UBERON:0004770 biolink:NamedThing articular system Anatomical system that consists of all the joints of the body. RBO_relaxed.owl UBERON:0000174 biolink:NamedThing excreta A portion of organism substance that is the product of an excretion process that will be eliminated from the body. An excretion process is elimination by an organism of the waste products that arise as a result of metabolic activity. RBO_relaxed.owl UBERON:0000456 biolink:NamedThing secretion of exocrine gland A portion of organism substance that is produced by exocrine glands. RBO_relaxed.owl UBERON:0002409 biolink:NamedThing pericardial fluid Transudate contained in the pericardial cavity.[FMA]. RBO_relaxed.owl UBERON:0006312 biolink:NamedThing ocular refractive media Body substance in a liquid or semi-solid state in the eyeball which serves to refract light. RBO_relaxed.owl UBERON:0006314 biolink:NamedThing bodily fluid Liquid components of living organisms. includes fluids that are excreted or secreted from the body as well as body water that normally is not. RBO_relaxed.owl UBERON:0006535 biolink:NamedThing skin secretion A portion of organism substance that secreted_by a zone of skin. RBO_relaxed.owl UBERON:0006537 biolink:NamedThing female reproductive gland secretion A portion of organism substance that is secreted by a female reproductive gland. RBO_relaxed.owl UBERON:0006538 biolink:NamedThing respiratory system fluid/secretion A portion of organism substance that secreted_by a respiratory system. RBO_relaxed.owl UBERON:0022293 biolink:NamedThing reproductive gland secretion A portion of organism substance that is secreted by a reproductive gland. RBO_relaxed.owl UBERON:0034873 biolink:NamedThing bodily gas Any substance in the body or expelled from the body that is in a gaseous state. RBO_relaxed.owl UBERON:0000912 biolink:NamedThing mucus Mucus is a bodily fluid consisting of a slippery secretion of the lining of the mucous membranes in the body. It is a viscous colloid containing antiseptic enzymes (such as lysozyme) and immunoglobulins. Mucus is produced by goblet cells in the mucous membranes that cover the surfaces of the membranes. It is made up of mucins and inorganic salts suspended in water. RBO_relaxed.owl UBERON:0001796 biolink:NamedThing aqueous humor of eyeball A thick watery refractive medium that fills the space between the lens and the cornea[WP]. RBO_relaxed.owl UBERON:0001970 biolink:NamedThing bile Vital aqueous secretion of the liver that is formed by hepatocytes and modified down stream by absorptive and secretory properties of the bile duct epithelium. RBO_relaxed.owl UBERON:0007794 biolink:NamedThing secretion of serous gland Any fluid produced by a serous gland. RBO_relaxed.owl UBERON:0013727 biolink:NamedThing notochordal fluid Fluid contained within the notochordal canal. RBO_relaxed.owl UBERON:0036217 biolink:NamedThing coelomic fluid A bodily fluid that is located in the coelom. RBO_relaxed.owl UBERON:0000209 biolink:NamedThing tetrapod frontal bone The bone forming the forehead and roof of the eye orbit. RBO_relaxed.owl UBERON:0002514 biolink:NamedThing intramembranous bone Bone tissue forms directly within mesenchyme, and does not replace other tissues[TAO]. Intramembranous ossification is the formation of bone in which osteoblasts secrete a collagen-proteoglycan matrix that binds calcium salts and becomes calcified[GO]. Intramembranous ossification is the way flat bones and the shell of a turtle are formed[GO]. Unlike endochondral ossification, cartilage is not present during intramembranous ossification[WP]. RBO_relaxed.owl UBERON:0008907 biolink:NamedThing dermal bone Skeletal element that forms superficially in the organism, usually in association with the ectoderm[VSAO]. RBO_relaxed.owl UBERON:0012071 biolink:NamedThing palate bone Any bone that is part of a palate. RBO_relaxed.owl UBERON:0010428 biolink:NamedThing flat bone A bone that is shaped as a broad flat plate and composed of two thin layers of compact tissue enclosing between them a variable quantity of cancellous tissue, which is the location of red bone marrow. RBO_relaxed.owl UBERON:0001676 biolink:NamedThing occipital bone The bone at the lower, posterior part of the skull. RBO_relaxed.owl UBERON:0011164 biolink:NamedThing neurocranium bone A bone that is part of a neurocranium [Automatically generated definition]. RBO_relaxed.owl UBERON:0001679 biolink:NamedThing ethmoid bone A bone in the skull that separates the nasal cavity from the brain. As such, it is located at the roof of the nose, between the two orbits. The cubical bone is lightweight due to a spongy construction. The ethmoid bone is one of the bones that makes up the orbit of the eye[WP]. RBO_relaxed.owl UBERON:0000219 biolink:NamedThing vertebral foramen of atlas RBO_relaxed.owl UBERON:0008429 biolink:NamedThing cervical vertebral foramen A vertebral foramen that is part of a cervical vertebra. RBO_relaxed.owl UBERON:0008432 biolink:NamedThing thoracic vertebral foramen A vertebral foramen that is part of a thoracic vertebra. RBO_relaxed.owl UBERON:0013685 biolink:NamedThing foramen of skull Anatomical space that is an opening in a bone of the skull. RBO_relaxed.owl UBERON:0011107 biolink:NamedThing synovial joint of pelvic girdle A synovial joint that is part of a pelvic girdle region. RBO_relaxed.owl UBERON:0011108 biolink:NamedThing synovial joint of pectoral girdle A synovial joint that is part of a pectoral girdle region. RBO_relaxed.owl UBERON:0011171 biolink:NamedThing joint connecting upper and lower jaws Synovial joint that articulates bones of upper and lower jaw. RBO_relaxed.owl UBERON:0002548 biolink:NamedThing larva A distinct juvenile form many animals undergo before metamorphosis into adults. Animals with indirect development such as insects, amphibians, or cnidarians typically have a larval phase of their life cycle. RBO_relaxed.owl UBERON:0003100 biolink:NamedThing female organism Gonochoristic organism that can produce female gametes. RBO_relaxed.owl UBERON:0009953 biolink:NamedThing post-embryonic organism A multicellular organism that existence_starts_with a post-embryonic stage. RBO_relaxed.owl UBERON:0000317 biolink:NamedThing colonic mucosa Mucosa that is part of a colon. The mucosa of the colon is lined by a simple columnar epithelium with a thin brush border and numerous goblet cells. RBO_relaxed.owl UBERON:0000320 biolink:NamedThing duodenal mucosa A mucosa that is part of a duodenum [Automatically generated definition]. RBO_relaxed.owl UBERON:0000355 biolink:NamedThing pharyngeal mucosa A mucosa that is part of a pharynx [Automatically generated definition]. RBO_relaxed.owl UBERON:0000379 biolink:NamedThing tracheal mucosa A mucosa that is part of a respiratory airway. RBO_relaxed.owl UBERON:0001204 biolink:NamedThing mucosa of small intestine A mucosa that is part of a small intestine [Automatically generated definition]. RBO_relaxed.owl UBERON:0001207 biolink:NamedThing mucosa of large intestine A mucosa that is part of a large intestine [Automatically generated definition]. RBO_relaxed.owl UBERON:0002469 biolink:NamedThing esophagus mucosa A mucosa that is part of a esophagus [Automatically generated definition]. RBO_relaxed.owl UBERON:0003343 biolink:NamedThing mucosa of oral region A mucosa that is part of a oral opening [Automatically generated definition]. RBO_relaxed.owl UBERON:0003346 biolink:NamedThing mucosa of rectum A mucosa that is part of a rectum [Automatically generated definition]. RBO_relaxed.owl UBERON:0003729 biolink:NamedThing mouth mucosa A mucous membrane that lines the mouth. RBO_relaxed.owl UBERON:0004785 biolink:NamedThing respiratory system mucosa The mucous membrane lining the respiratory tract. RBO_relaxed.owl UBERON:0004786 biolink:NamedThing gastrointestinal system mucosa A mucosa that is part of a gastrointestinal system. RBO_relaxed.owl UBERON:0004988 biolink:NamedThing mucosa of cystic duct A mucosa that is part of a cystic duct [Automatically generated definition]. RBO_relaxed.owl UBERON:0004993 biolink:NamedThing mucosa of sigmoid colon A mucosa that is part of a sigmoid colon [Automatically generated definition]. RBO_relaxed.owl UBERON:0004995 biolink:NamedThing mucosa of body of stomach A mucosa that is part of a body of stomach [Automatically generated definition]. RBO_relaxed.owl UBERON:0004998 biolink:NamedThing mucosa of pylorus A mucosa that is part of a pylorus [Automatically generated definition]. RBO_relaxed.owl UBERON:0005000 biolink:NamedThing mucosa of common bile duct A mucosa that is part of a common bile duct [Automatically generated definition]. RBO_relaxed.owl UBERON:0005001 biolink:NamedThing mucosa of common hepatic duct A mucosa that is part of a common hepatic duct [Automatically generated definition]. RBO_relaxed.owl UBERON:0005002 biolink:NamedThing mucosa of right hepatic duct A mucosa that is part of a right hepatic duct [Automatically generated definition]. RBO_relaxed.owl UBERON:0005003 biolink:NamedThing mucosa of left hepatic duct A mucosa that is part of a left hepatic duct [Automatically generated definition]. RBO_relaxed.owl UBERON:0005031 biolink:NamedThing mucosa of upper lip A mucosa that is part of a upper lip [Automatically generated definition]. RBO_relaxed.owl UBERON:0005032 biolink:NamedThing mucosa of lower lip A mucosa that is part of a lower lip [Automatically generated definition]. RBO_relaxed.owl UBERON:0012480 biolink:NamedThing cloacal mucosa A mucosa that is part of a cloaca [Automatically generated definition]. RBO_relaxed.owl UBERON:0012651 biolink:NamedThing mucosa of gastroduodenal junction A mucosa that is part of a gastroduodenal junction. RBO_relaxed.owl UBERON:0019042 biolink:NamedThing reproductive system mucosa RBO_relaxed.owl UBERON:0036294 biolink:NamedThing mucosa of lip A mucosa that is part of a lip region [Automatically generated definition]. RBO_relaxed.owl UBERON:0000414 biolink:NamedThing mucous gland A gland in which the principal secretory cells are mucus secreting cells. RBO_relaxed.owl UBERON:0010047 biolink:NamedThing oral gland Gland of the epithelium lining the oral cavity. The most common are the salivary glands. RBO_relaxed.owl UBERON:0010243 biolink:NamedThing merocrine gland An exocrine gland whose secretions are excreted via exocytosis from secretory cells into an epithelial-walled duct or ducts and thence onto a bodily surface or into the lumen; the gland releases its product and no part of the gland is lost or damaged. RBO_relaxed.owl UBERON:0019319 biolink:NamedThing exocrine gland of integumental system An exocrine gland that is part of a integumental system. RBO_relaxed.owl UBERON:0003294 biolink:NamedThing gland of foregut A gland that is part of a foregut [Automatically generated definition]. RBO_relaxed.owl UBERON:0000326 biolink:NamedThing pancreatic juice Pancreatic juice is slightly alkaline and contains numerous enzymes and inactive enzyme precursors including alpha-amylase, chymotrypsinogen, lipase, procarboxypeptidase, proelastase, prophospholipase A2, ribonuclease, and trypsinogen. Its high concentration of bicarbonate ions helps to neutralize the acid from the stomach. RBO_relaxed.owl UBERON:0001971 biolink:NamedThing gastric juice RBO_relaxed.owl UBERON:0002466 biolink:NamedThing intestine secretion Clear to pale yellow watery secretions from the glands lining the small intestine walls. Secretion is stimulated by the mechanical pressure of partly digested food in the intestine. RBO_relaxed.owl UBERON:0004792 biolink:NamedThing secretion of endocrine pancreas A secretion that is part of a endocrine pancreas [Automatically generated definition]. RBO_relaxed.owl UBERON:0004793 biolink:NamedThing secretion of exocrine pancreas A secretion that is part of a exocrine pancreas [Automatically generated definition]. RBO_relaxed.owl UBERON:0004794 biolink:NamedThing esophagus secretion A secretion that is part of a esophagus [Automatically generated definition]. RBO_relaxed.owl UBERON:0004795 biolink:NamedThing pancreas secretion A secretion that is part of a pancreas [Automatically generated definition]. RBO_relaxed.owl UBERON:0000328 biolink:NamedThing gut wall The wall of the digestive tract. This encompasses all parts of the digestive tract with the exception of the lumen (cavity). RBO_relaxed.owl UBERON:0000415 biolink:NamedThing artery wall An anatomical wall that is part of an artery [Automatically generated definition]. RBO_relaxed.owl UBERON:0001096 biolink:NamedThing wall of esophagus An anatomical wall that is part of a esophagus [Automatically generated definition]. RBO_relaxed.owl UBERON:0001167 biolink:NamedThing wall of stomach The layered structure that makes up the stomach, typiclly consists of a serous coat, a muscular coat, a mucous membrane, and other tissue layers in between. RBO_relaxed.owl UBERON:0001168 biolink:NamedThing wall of small intestine An anatomical wall that is part of a small intestine [Automatically generated definition]. RBO_relaxed.owl UBERON:0001169 biolink:NamedThing wall of large intestine An anatomical wall that is part of a large intestine [Automatically generated definition]. RBO_relaxed.owl UBERON:0001262 biolink:NamedThing wall of intestine An anatomical wall that is part of a intestine [Automatically generated definition]. RBO_relaxed.owl UBERON:0003697 biolink:NamedThing abdominal wall The tissues that surround the organs that are present within the abdominal cavity. The abdominal wall tissue is composed of layers of fat, parietal peritoneum, fascia, and muscles. RBO_relaxed.owl UBERON:0004663 biolink:NamedThing aorta wall An anatomical wall that is part of an aorta, enclosing the luminal space. RBO_relaxed.owl UBERON:0004784 biolink:NamedThing heart ventricle wall An anatomical wall that is part of a cardiac ventricle [Automatically generated definition]. RBO_relaxed.owl UBERON:0036351 biolink:NamedThing wall of brachiocephalic artery RBO_relaxed.owl UBERON:0036352 biolink:NamedThing wall of subclavian artery RBO_relaxed.owl UBERON:0036422 biolink:NamedThing wall of pulmonary artery RBO_relaxed.owl UBERON:0036553 biolink:NamedThing wall of synovial tendon sheath RBO_relaxed.owl UBERON:0037094 biolink:NamedThing wall of common carotid artery RBO_relaxed.owl UBERON:0000332 biolink:NamedThing yellow bone marrow Bone marrow in which the fat cells predominate in the meshes of the reticular network. RBO_relaxed.owl UBERON:0000361 biolink:NamedThing red bone marrow The red vascular substance consisting of connective tissue and blood vessels, containing primitive blood cells, macrophages, megakaryocytes, and fat cells. Red marrow is found in the cavities of many bones. It manufactures and releases leukocytes and erythrocytes into the bloodstream. RBO_relaxed.owl UBERON:0000333 biolink:NamedThing intestinal gland A gland that is part of the intestinal mucosa. Examples include the intestinal crypts, duodenal gland[cjm]. RBO_relaxed.owl UBERON:0002368 biolink:NamedThing endocrine gland Endocrine glands are glands of the endocrine system that secrete their products directly into the circulatory system rather than through a duct.[WP, modified]. RBO_relaxed.owl UBERON:0003295 biolink:NamedThing pharyngeal gland Racemose mucous glands beneath the mucous membrane of the pharynx. RBO_relaxed.owl UBERON:0003297 biolink:NamedThing gland of integumental system A gland that is part of a integumental system [Automatically generated definition]. RBO_relaxed.owl UBERON:0003937 biolink:NamedThing reproductive gland Any of the organized aggregations of cells that function as secretory or excretory organs and are associated with reproduction. RBO_relaxed.owl UBERON:0004859 biolink:NamedThing eye gland A gland that is part of a eye. The eye is a compound unit which depending on the species may consist of an eyeballs plus associated ducts and integumentary structures. Eye glands therefore include the various types of lacrimal gland, the various types of apocrine and sebaceous glands associated with the eyelid. RBO_relaxed.owl UBERON:0005058 biolink:NamedThing hemolymphoid system gland A gland that is part of a hemolymphoid system [Automatically generated definition]. RBO_relaxed.owl UBERON:0005250 biolink:NamedThing stomatodeum gland A gland that is part of a stomodeum. RBO_relaxed.owl UBERON:0007771 biolink:NamedThing epidermis gland A gland that is part of a epidermis. RBO_relaxed.owl UBERON:0012478 biolink:NamedThing cloacal gland A gland that is part of a cloaca. RBO_relaxed.owl UBERON:0013158 biolink:NamedThing foregut-midgut junction gland A gland that is part of a foregut-midgut junction. RBO_relaxed.owl UBERON:0015152 biolink:NamedThing gland of ocular region A gland that is typically found in or near the orbital region, in or around either the medial or lateral canthi, and is typically associated with secretions onto the eyeball or associated ducts. Includes the Harderian, nictitans and lacrimal glands. RBO_relaxed.owl UBERON:0036225 biolink:NamedThing respiratory system gland Any gland that is part os the respiratory system. RBO_relaxed.owl UBERON:0001212 biolink:NamedThing duodenal gland A compound tubular submucosal gland found in that portion of the duodenum which is above the hepatopancreatic sphincter (Sphincter of Oddi). The main function of these glands is to produce a mucus-rich alkaline secretion (containing bicarbonate)[WP]. RBO_relaxed.owl UBERON:0008989 biolink:NamedThing submucosal esophageal gland One of the racemose glands in the walls of the esophagus that in humans are small and serve principally to lubricate the food but in some birds secrete a milky fluid on which the young are fed. RBO_relaxed.owl UBERON:0000377 biolink:NamedThing maxillary nerve The sensory nerve subdivision of the trigeminal nerve that transmits sensory information from the palate, upper teeth and gingiva, the skin between the palpebral fissure and the mouth, and from the nasal cavity and maxillary sinuses. RBO_relaxed.owl UBERON:0011779 biolink:NamedThing nerve of head region A nerve that is part of a head. RBO_relaxed.owl UBERON:0034728 biolink:NamedThing autonomic nerve The autonomic nerve is a small nerve which carries postganglionic sympathetic and parasympathetic neurons from the zygomaticotemporal nerve; a branch of the maxillary nerve, to the lacrimal nerve; a branch of the ophthalmic nerve. These neurons derive from the superior cervical ganglion and the pterygopalatine ganglion respectively. They will travel to the lacrimal gland via the lacrimal nerve. Parasympathetic will induce lacrimation and vice versa. RBO_relaxed.owl UBERON:0036264 biolink:NamedThing zygomaticotemporal nerve The zygomaticotemporal nerve or zygomaticotemporal branch (temporal branch) is derived from the maxillary branch of the trigeminal nerve (Cranial nerve V). It runs along the lateral wall of the orbit in a groove in the zygomatic bone, receives a branch of communication from the lacrimal, and passes through zygomaticotemporal foramen in the zygomatic bone to enter the temporal fossa. It ascends between the bone, and substance of the Temporalis muscle, pierces the temporal fascia about 2.5 cm. above the zygomatic arch, and is distributed to the skin of the side of the forehead, and communicates with the facial nerve and with the auriculotemporal branch of the mandibular nerve. As it pierces the temporal fascia, it gives off a slender twig, which runs between the two layers of the fascia to the lateral angle of the orbit. RBO_relaxed.owl UBERON:0000957 biolink:NamedThing lamina Any thin layer or plate. RBO_relaxed.owl UBERON:0005292 biolink:NamedThing extraembryonic tissue Portion of tissue that is contiguous with the embryo and is comprised of portions of tissue or cells that will not contribute to the embryo. RBO_relaxed.owl UBERON:0007475 biolink:NamedThing matrix-based tissue A tissue whose predominant feature is extracellular matrix which may or may not be highly hydrated or calcified. RBO_relaxed.owl UBERON:0007688 biolink:NamedThing anlage Anlagen are populations of contiguous cells, typically arranged in one plane, that are morphologically indistinct, but that already correspond in extent to a later organ/tissue. RBO_relaxed.owl UBERON:0015757 biolink:NamedThing heterogeneous tissue RBO_relaxed.owl UBERON:0000474 biolink:NamedThing female reproductive system The organs and associated structures associated with bearing offspring in a female animal. RBO_relaxed.owl UBERON:0000477 biolink:NamedThing anatomical cluster Anatomical group that has its parts adjacent to one another.|Anatomical group whose component anatomical structures lie in close proximity to each other. RBO_relaxed.owl UBERON:0015203 biolink:NamedThing non-connected functional system An anatomical group whose component structures share a common function. RBO_relaxed.owl UBERON:0001048 biolink:NamedThing primordium Primordia are populations of contiguous cells that are morphologically distinct and already correspond in extent to a later organ/tissue[FBbt, Hartenstein, V. (2004)]. RBO_relaxed.owl UBERON:0009145 biolink:NamedThing pharyngeal region of foregut RBO_relaxed.owl UBERON:0016888 biolink:NamedThing transitional anatomical structure An embryonic anatomical entity that will turn into one or more other anatomical entities, perhaps with other anatomical entities, later in development. RBO_relaxed.owl UBERON:0017650 biolink:NamedThing developing mesenchymal structure A mesenchyme-derived anatomical entity undergoing a transtion to become another structure. RBO_relaxed.owl UBERON:0006915 biolink:NamedThing stratified squamous epithelium Multilaminar epithelium which consists of more than one layer of squamous cells only one layer of which is in contact with a basement membrane. Examples: keratinized stratified squamous epithelium, epithelium of wall of esophagus.[FMA]. RBO_relaxed.owl UBERON:0006920 biolink:NamedThing esophagus squamous epithelium A squamous epithelium that is part of a esophagus. RBO_relaxed.owl UBERON:0006921 biolink:NamedThing stomach squamous epithelium A squamous epithelium that is part of a stomach. RBO_relaxed.owl UBERON:0000489 biolink:NamedThing cavitated compound organ Compound organ that contains one or more macroscopic anatomical spaces. RBO_relaxed.owl UBERON:0015228 biolink:NamedThing circulatory organ A hollow, muscular organ, which, by contracting rhythmically, contributes to the circulation of lymph, blood or analogs. Examples: a chambered vertebrate heart; the tubular peristaltic heart of ascidians; the dorsal vessel of an insect; the lymoh heart of a reptile. RBO_relaxed.owl UBERON:0011270 biolink:NamedThing dorsal trunk The part of the trunk that is in the dorsum[cjm]. RBO_relaxed.owl UBERON:0016566 biolink:NamedThing pit An roughly circular indentation in a surface. RBO_relaxed.owl UBERON:0003509 biolink:NamedThing arterial blood vessel A blood vessel that is part of the arterial system. Includes artery, arteriole and aorta. RBO_relaxed.owl UBERON:0003643 biolink:NamedThing respiratory system arterial blood vessel An arterial blood vessel that is part of a respiratory system [Automatically generated definition]. RBO_relaxed.owl UBERON:0003519 biolink:NamedThing thoracic cavity blood vessel A blood vessel that is part of a thoracic cavity [Automatically generated definition]. RBO_relaxed.owl UBERON:0003473 biolink:NamedThing thoracic cavity artery An artery that is part of a thoracic cavity[cjm]. RBO_relaxed.owl UBERON:0003479 biolink:NamedThing thoracic cavity vein A vein that is part of a thoracic cavity [Automatically generated definition]. RBO_relaxed.owl UBERON:0013768 biolink:NamedThing great vessel of heart Great vessels is a term used to refer collectively to the large vessels that bring blood to and from the heart. RBO_relaxed.owl UBERON:0002016 biolink:NamedThing pulmonary vein Pulmonary veins are blood vessels that transport blood from the lungs to the heart[GO]. RBO_relaxed.owl UBERON:0004087 biolink:NamedThing vena cava Any of the veins that carries deoxygenated blood from a part of the body into the right atrium of the heart. RBO_relaxed.owl UBERON:0002406 biolink:NamedThing pericardial sac A double-walled sac containing the heart and the roots of the great vessels. RBO_relaxed.owl UBERON:0003827 biolink:NamedThing thoracic segment bone A bone that is part of a thorax [Automatically generated definition]. RBO_relaxed.owl UBERON:0003830 biolink:NamedThing thoracic segment muscle Any muscle organ that is part of a thorax [Automatically generated definition]. RBO_relaxed.owl UBERON:0015008 biolink:NamedThing thoracic vertebra endochondral element A vertebral endochondral element in the thoracic region of the vertebral column. RBO_relaxed.owl UBERON:0015204 biolink:NamedThing glandular system A non-connected functional system that is composed primarily of a gland. RBO_relaxed.owl UBERON:0000962 biolink:NamedThing nerve of cervical vertebra The cervical nerves are the spinal nerves from the cervical vertebrae. Although there are seven cervical vertebrae (C1-C7), there are eight cervical nerves (C1-C8). All nerves except C8 emerge above their corresponding vertebrae, while the C8 nerve emerges below the C7 vertebra. (In the other portions of the spine, the nerve emerges below the vertebra with the same name. Dorsal (posterior) distribution includes the greater occipital (C2) and third occipital (C3). Ventral (anterior) distribution includes the cervical plexus (C1-C4) and brachial plexus (C5-C8) [WP,unvetted]. RBO_relaxed.owl UBERON:0003726 biolink:NamedThing thoracic nerve The twelve spinal nerves on each side of the thorax. They include eleven INTERCOSTAL NERVES and one subcostal nerve. Both sensory and motor, they supply the muscles and skin of the thoracic and abdominal walls. RBO_relaxed.owl UBERON:0003727 biolink:NamedThing intercostal nerve The intercostal nerves are the anterior divisions (rami anteriores; ventral divisions) of the thoracic spinal nerves from T1 to T11. Each nerve is connected with the adjoining ganglion of the sympathetic trunk by a gray and a white ramus communicans. The intercostal nerves are distributed chiefly to the thoracic pleura and abdominal peritoneum and differ from the anterior divisions of the other spinal nerves in that each pursues an independent course without plexus formation. The first two nerves supply fibers to the upper limb in addition to their thoracic branches; the next four are limited in their distribution to the parietes of the thorax; the lower five supply the parietes of the thorax and abdomen. The 7th intercostal nerve terminates at the xyphoid process, at the lower end of the sternum. The 10th intercostal nerve terminates at the umbilicus. The twelfth thoracic is distributed to the abdominal wall and groin. [WP,unvetted]. RBO_relaxed.owl UBERON:0000963 biolink:NamedThing head sensillum RBO_relaxed.owl UBERON:6007240 biolink:NamedThing insect embryonic/larval sensillum Any sensillum (UBERON:6007152) that is part of some larva (UBERON:6001727). RBO_relaxed.owl UBERON:6007242 biolink:NamedThing insect embryonic/larval head sensillum Any sensillum (UBERON:6007152) that is part of some larval head (UBERON:6001730). RBO_relaxed.owl UBERON:0001201 biolink:NamedThing serosa of stomach The outermost layer of the stomach wall, consisting of layers of connective tissue continuous with the peritoneum. RBO_relaxed.owl UBERON:0001206 biolink:NamedThing serosa of small intestine A serous membrane that is part of a small intestine [Automatically generated definition]. RBO_relaxed.owl UBERON:0001209 biolink:NamedThing serosa of large intestine A serous membrane that is part of a large intestine [Automatically generated definition]. RBO_relaxed.owl UBERON:0001243 biolink:NamedThing serosa of intestine A serous membrane that is part of a wall of intestine [Automatically generated definition]. RBO_relaxed.owl UBERON:0001975 biolink:NamedThing serosa of esophagus A serous membrane that is part of a esophagus [Automatically generated definition]. RBO_relaxed.owl UBERON:0002095 biolink:NamedThing mesentery Anatomical organ component composed of a double layer of serous membrane that suspends a viscus from the body wall or connects adjacent viscera and in doing so conveys blood vessels, lymphatics and nerves to and from the viscera. Examples: greater omentum, broad ligament of uterus, sigmoid mesocolon. RBO_relaxed.owl UBERON:0002357 biolink:NamedThing serous pericardium Serous membrane which is divided into parietal and visceral serous pericardium. RBO_relaxed.owl UBERON:0003334 biolink:NamedThing serosa of rectum A serous membrane that is part of a rectum [Automatically generated definition]. RBO_relaxed.owl UBERON:0003335 biolink:NamedThing serosa of colon A serous membrane that is part of a colon [Automatically generated definition]. RBO_relaxed.owl UBERON:0003336 biolink:NamedThing serosa of duodenum A serous membrane that is part of a duodenum [Automatically generated definition]. RBO_relaxed.owl UBERON:0004782 biolink:NamedThing gastrointestinal system serosa A serous membrane that is part of a digestive system [Automatically generated definition]. RBO_relaxed.owl UBERON:0007616 biolink:NamedThing layer of synovial tissue A thin, loose vascular connective tissue that makes up the membranes surrounding joints and the sheaths protecting tendons (particularly flexor tendons in the hands and feet) where they pass over bony prominences. Synovial tissue contains synovial cells, which secrete a viscous liquid called synovial fluid; this liquid contains protein and hyaluronic acid and serves as a lubricant and nutrient for the joint cartilage surfaces[BTO]. Synovial tissue can be found in tendons (tissues that connect muscle to bone), bursae (fluid-filled, cushioning sacs found in spaces between tendons, ligaments, and bones), and the cavity (hollow enclosed area) that separates the bones of a freely movable joint, such as the knee or elbow[BTO]. RBO_relaxed.owl UBERON:0012483 biolink:NamedThing serosa of cloaca A serous membrane that is part of a cloaca [Automatically generated definition]. RBO_relaxed.owl UBERON:0000982 biolink:NamedThing skeletal joint Anatomical structure that consists of two or more adjacent skeletal structures, which may be interconnected by various types of tissue[VSAO]. RBO_relaxed.owl UBERON:0004905 biolink:NamedThing articulation Anatomical structure that connects two or more adjacent skeletal elements or hardened body parts. RBO_relaxed.owl UBERON:0001943 biolink:NamedThing midbrain tegmentum Ventral part of the midbrain, separated from the hindbrain by the isthmus[ISBN:0471888893]. Subdivision of the midbrain lying anterior to the tectum and posterior to the substantia nigra and cerebral peduncle[FMA] The part of the midbrain extending from the substantia nigra to the cerebral aqueduct in a horizontal section of the midbrain. It forms the floor of the midbrain that surrounds the cerebral aqueduct[WP]. RBO_relaxed.owl UBERON:0002275 biolink:NamedThing reticular formation A composite substructure of the brainstem that consists of the midbrain reticular formation, the pontine reticular formation and the medullary reticular formation ( Carpenter-1983 ). RBO_relaxed.owl UBERON:8440015 biolink:NamedThing noradrenergic cell groups Collections of neurons in the central nervous system that have been demonstrated by histochemical fluorescence to contain the neurotransmitter norepinephrine (noradrenalin). RBO_relaxed.owl UBERON:0001007 biolink:NamedThing digestive system Anatomical system that has as its parts the organs devoted to the ingestion, digestion, and assimilation of food and the discharge of residual wastes. RBO_relaxed.owl UBERON:0001009 biolink:NamedThing circulatory system Organ system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells, etc. to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis[WP]. RBO_relaxed.owl UBERON:0002193 biolink:NamedThing hemolymphoid system Anatomical cluster consisting of the hematopoietic system and the lymphoid system, or its analogs. RBO_relaxed.owl UBERON:0004456 biolink:NamedThing entire sense organ system Sum of all sensory systems in an organism. RBO_relaxed.owl UBERON:0005409 biolink:NamedThing alimentary part of gastrointestinal system The part of the digestive system that excludes the hepatobiliary system. RBO_relaxed.owl UBERON:0007798 biolink:NamedThing vascular system Anatomical system that consists of all blood and lymph vessels. RBO_relaxed.owl UBERON:8450002 biolink:NamedThing excretory system An anatomical system that eliminates waste products that arise as a result of metabolic activity. RBO_relaxed.owl UBERON:0003134 biolink:NamedThing female reproductive organ A female organ involved in reproduction. RBO_relaxed.owl UBERON:0009117 biolink:NamedThing indifferent gonad A gonad prior to differentiating into a definitive testis or ovary. RBO_relaxed.owl UBERON:0003975 biolink:NamedThing internal female genitalia The internal feminine genital organs, including the ovaries, uterine tubes, uterus, uterine cervix, and vagina. RBO_relaxed.owl UBERON:0005056 biolink:NamedThing external female genitalia An external genitalia that is part of a female reproductive system [Automatically generated definition]. RBO_relaxed.owl UBERON:3000961 biolink:NamedThing external integument structure Structures of the dermis, epidermis, glands and pigment cells recognizable on the external surfaces of the integument. RBO_relaxed.owl UBERON:3000972 biolink:NamedThing head external integument structure Dermal, epidermal, glandular and pigment structures of the external head integument. RBO_relaxed.owl UBERON:3000977 biolink:NamedThing body external integument structure Dermal, epidermal, glandular and pigment structures of the body integument. RBO_relaxed.owl UBERON:3000982 biolink:NamedThing tail external integument structure Dermal, epidermal, glandular and pigment structures of the tail integument. RBO_relaxed.owl UBERON:0011822 biolink:NamedThing dense irregular connective tissue Irregular connective tissue is an irregular connective tissue, the intercellular matrix of which contains a dense irregular network of collagen and elastic fiber bundles. Examples: connective tissue of peritoneum, connective tissue of fibrous pericardium. RBO_relaxed.owl UBERON:0011824 biolink:NamedThing fibrous connective tissue RBO_relaxed.owl UBERON:0004904 biolink:NamedThing neuron projection bundle connecting eye with brain A neuron projection bundle that connects the retina or its analog in the eye with the brain. This includes the vertebrate optic nerve (not truly a nerve) as well as analogous structures such as the Bolwig nerve in Drosophila. RBO_relaxed.owl UBERON:0001027 biolink:NamedThing sensory nerve A nerve that transmits from sensory receptors on the surface of the body to the central nervous system. RBO_relaxed.owl UBERON:0001884 biolink:NamedThing phrenic nerve A nerve that arises from the caudal cervical nerves and is primarily the motor nerve of the diaphragm but also sends sensory fibers to the pericardium. RBO_relaxed.owl UBERON:0003429 biolink:NamedThing abdomen nerve A nerve that is part of an abdomen [Automatically generated definition]. RBO_relaxed.owl UBERON:0003430 biolink:NamedThing neck nerve A nerve that is part of a neck [Automatically generated definition]. RBO_relaxed.owl UBERON:0003438 biolink:NamedThing iris nerve Any nerve that innervates the iris. RBO_relaxed.owl UBERON:0003439 biolink:NamedThing nerve of trunk region A nerve that is part of the trunk region of the body (not to be confused with a nerve trunk). RBO_relaxed.owl UBERON:0003443 biolink:NamedThing thoracic cavity nerve A nerve that is located in a thoracic cavity [Automatically generated definition]. RBO_relaxed.owl UBERON:0003444 biolink:NamedThing pelvis nerve A nerve that is part of a pelvis [Automatically generated definition]. RBO_relaxed.owl UBERON:0003715 biolink:NamedThing splanchnic nerve The major nerves supplying sympathetic innervation to the abdomen, including the greater, lesser, and lowest (or smallest) splanchnic nerves that are formed by preganglionic fibers from the spinal cord which pass through the paravertebral ganglia and then to the celiac ganglia and plexuses and the lumbar splanchnic nerves carry fibers which pass through the lumbar paravertebral ganglia to the mesenteric and hypogastric ganglia. RBO_relaxed.owl UBERON:0003824 biolink:NamedThing nerve of thoracic segment A nerve that is part of a thorax [Automatically generated definition]. RBO_relaxed.owl UBERON:0003825 biolink:NamedThing nerve of abdominal segment A nerve that is part of an abdominal segment of trunk [Automatically generated definition]. RBO_relaxed.owl UBERON:0004215 biolink:NamedThing back nerve A nerve that is part of a back [Automatically generated definition]. RBO_relaxed.owl UBERON:0034729 biolink:NamedThing sympathetic nerve RBO_relaxed.owl UBERON:0005631 biolink:NamedThing extraembryonic membrane Intrinsic membrane that arises from embryonic germ layers and grow to surround the developing embryo. RBO_relaxed.owl UBERON:0004912 biolink:NamedThing biliary bud RBO_relaxed.owl UBERON:0008836 biolink:NamedThing liver bud RBO_relaxed.owl UBERON:0015410 biolink:NamedThing heart plus pericardium RBO_relaxed.owl UBERON:0003915 biolink:NamedThing endothelial tube Any endothelium that has the quality of being cylindrical [Automatically generated definition]. RBO_relaxed.owl UBERON:0007500 biolink:NamedThing epithelial tube open at both ends An epithelial tube open at both ends that allows fluid flow. RBO_relaxed.owl UBERON:0003055 biolink:NamedThing periderm A temporary epithelium that derives from the outer layer of the ectdoerm and is shed once the inner layer differentiates to form a true epidermis. RBO_relaxed.owl UBERON:0013694 biolink:NamedThing brain endothelium Vascular endothelium found in blood vessels of the blood-brain-barrier. RBO_relaxed.owl UBERON:0016879 biolink:NamedThing future central nervous system Primordium that develops into the central nervous system. RBO_relaxed.owl UBERON:0007284 biolink:NamedThing presumptive neural plate A presumptive structure that has the potential to develop into a neural plate. RBO_relaxed.owl UBERON:0001084 biolink:NamedThing skin of head A zone of skin that is part of a head [Automatically generated definition]. RBO_relaxed.owl UBERON:0001085 biolink:NamedThing skin of trunk A zone of skin that is part of a trunk [Automatically generated definition]. RBO_relaxed.owl UBERON:0001415 biolink:NamedThing skin of pelvis A zone of skin that is part of a pelvis [Automatically generated definition]. RBO_relaxed.owl UBERON:0001417 biolink:NamedThing skin of neck A zone of skin that is part of a neck [Automatically generated definition]. RBO_relaxed.owl UBERON:0001418 biolink:NamedThing skin of thorax A zone of skin that is part of a thorax [Automatically generated definition]. RBO_relaxed.owl UBERON:0001458 biolink:NamedThing skin of lip A zone of skin that is part of a lip [Automatically generated definition]. RBO_relaxed.owl UBERON:0003534 biolink:NamedThing tail skin A zone of skin that is part of a tail [Automatically generated definition]. RBO_relaxed.owl UBERON:0003836 biolink:NamedThing abdominal segment skin A skin of body that is part of an abdominal segment of trunk [Automatically generated definition]. RBO_relaxed.owl UBERON:0012180 biolink:NamedThing head or neck skin A zone of skin that is part of a craniocervical region. RBO_relaxed.owl UBERON:0018150 biolink:NamedThing skin of lower lip A zone of skin that is part of a lower lip. RBO_relaxed.owl UBERON:0018151 biolink:NamedThing skin of upper lip A zone of skin that is part of a upper lip. RBO_relaxed.owl UBERON:1000021 biolink:NamedThing skin of face A zone of skin that is part of the face. RBO_relaxed.owl UBERON:8480025 biolink:NamedThing skin of clavicle region A zone of skin that is above the clavicle zone in the pectoral girdle region. RBO_relaxed.owl UBERON:8480029 biolink:NamedThing skin of external genitalia A zone of skin that is part of the external genitalia. RBO_relaxed.owl UBERON:8480074 biolink:NamedThing skin of gonad A zone of skin part of some gonad. RBO_relaxed.owl UBERON:0001070 biolink:NamedThing external carotid artery A terminal branch of the left or right common carotid artery which supplies oxygenated blood to to the throat, neck glands, tongue, face, mouth, ear, scalp and dura mater of the meninges[MP]. RBO_relaxed.owl UBERON:0001071 biolink:NamedThing superficial cervical artery It ascends beneath the anterior margin of the trapezius, distributing branches to it, and to the neighboring muscles and lymph glands in the neck, and anastomosing with the superficial branch of the descending branch of the occipital artery. RBO_relaxed.owl UBERON:0012320 biolink:NamedThing cervical artery An artery of the neck. RBO_relaxed.owl UBERON:0012321 biolink:NamedThing deep cervical artery The deep cervical artery (Profunda cervicalis) is an artery of the neck. RBO_relaxed.owl UBERON:0012324 biolink:NamedThing transverse cervical artery The transverse cervical artery (transverse artery of neck, transversa colli artery) is a branch of the thyrocervical trunk, running at a higher level than the suprascapular artery. RBO_relaxed.owl UBERON:0001072 biolink:NamedThing posterior vena cava A vein that carries deoxygenated blood from the lower half of the body into the right atrium of the heart. RBO_relaxed.owl UBERON:0001585 biolink:NamedThing anterior vena cava A vein that carries deoxygenated blood from the upper half of the body into the right atrium of the heart. RBO_relaxed.owl UBERON:0001073 biolink:NamedThing ileocecal junction A point along the course of the gastrointestinal tract where the small intestine (ileum) ends as it opens into the cecal portion of the large intestine; occurs usually within the iliac fossa, demarcated internally as the ileocecal orifice. RBO_relaxed.owl UBERON:0006235 biolink:NamedThing foregut-midgut junction An anatomical junctions that overlaps the foregut and midgut. RBO_relaxed.owl UBERON:0006264 biolink:NamedThing mouth-foregut junction An anatomical junctions that overlaps the mouth and foregut. RBO_relaxed.owl UBERON:0012650 biolink:NamedThing gastroduodenal junction An anatomical junction that connects a stomach and connects a duodenum. RBO_relaxed.owl UBERON:0015178 biolink:NamedThing somite border A region of somite adjacent to presomitic mesoderm. RBO_relaxed.owl UBERON:0015485 biolink:NamedThing choledocho-duodenal junction Hat part of the duodenal wall traversed by the ductus choledochus, ductus pancreaticus, and ampulla. RBO_relaxed.owl UBERON:0036214 biolink:NamedThing rectosigmoid junction An anatomical junction that is between the sigmoid colon and rectum. RBO_relaxed.owl UBERON:1100000 biolink:NamedThing digestive tract junction An anatomical junction between two parts of the digestive tract. RBO_relaxed.owl UBERON:8410024 biolink:NamedThing intestinal junction An anatomical junction between two parts of the intestine. RBO_relaxed.owl UBERON:0001081 biolink:NamedThing endocardium of ventricle Endocardium that is part of the cardiac ventricle. RBO_relaxed.owl UBERON:0001136 biolink:NamedThing mesothelium Simple squamous epithelium of mesodermal origin which lines serous membranes. Examples: mesothelium of pleura, mesothelium of peritoneum[FMA]. Wikipedia: The mesothelium is a membrane that forms the lining of several body cavities: the pleura (thoracal cavity), peritoneum (abdominal cavity including the mesentery) and pericardium (heart sac). Mesothelial tissue also surrounds the male internal reproductive organs (the tunica vaginalis testis) and covers the internal reproductive organs of women (the tunica serosa uteri). RBO_relaxed.owl UBERON:0002166 biolink:NamedThing endocardium of atrium Endocardium that is part of the atrium. RBO_relaxed.owl UBERON:0005243 biolink:NamedThing interventricular septum endocardium An endocardium that is part of a interventricular septum [Automatically generated definition]. RBO_relaxed.owl UBERON:0034903 biolink:NamedThing left atrium endocardium Endocardium that is part of the left atrium. RBO_relaxed.owl UBERON:0001082 biolink:NamedThing epicardium of ventricle An epicardial layer that lines a cardiac ventricle. RBO_relaxed.owl UBERON:0001083 biolink:NamedThing myocardium of ventricle Muscular layer of the cardiac ventricle composed of a compact myocardial layer surrounding the trabecular layer. RBO_relaxed.owl UBERON:0002349 biolink:NamedThing myocardium The middle layer of the heart, comprised mainly of striated cardiac muscle fibers. RBO_relaxed.owl UBERON:0002302 biolink:NamedThing myocardium of atrium The atrial part of middle layer of the heart, comprised of involuntary muscle. RBO_relaxed.owl UBERON:0004265 biolink:NamedThing outflow tract myocardium A myocardium that is part of a outflow tract [Automatically generated definition]. RBO_relaxed.owl UBERON:0005248 biolink:NamedThing bulbus cordis myocardium A myocardium that is part of a bulbus cordis [Automatically generated definition]. RBO_relaxed.owl UBERON:0036290 biolink:NamedThing myocardium of anterior wall of left ventricle RBO_relaxed.owl UBERON:0036291 biolink:NamedThing myocardium of anterior wall of right ventricle RBO_relaxed.owl UBERON:0001087 biolink:NamedThing pleural fluid Transudate contained in the pleural cavity. RBO_relaxed.owl UBERON:0001090 biolink:NamedThing synovial fluid Joint fluid is a transudate of plasma that is actively secreted by synovial cells. RBO_relaxed.owl UBERON:0001268 biolink:NamedThing peritoneal fluid Transudate contained in the peritoneal cavity. RBO_relaxed.owl UBERON:0036244 biolink:NamedThing secretion of serous membrane A transudate found in the serous sac. RBO_relaxed.owl UBERON:0001092 biolink:NamedThing vertebral bone 1 The first vertebral bone in the vertebral column. RBO_relaxed.owl UBERON:0001093 biolink:NamedThing vertebral bone 2 The second vertebral bone in the vertebral column. RBO_relaxed.owl UBERON:0001095 biolink:NamedThing caudal vertebra Any vertebral bone that is part of the caudal region of the vertebral column (tail or coccyx). RBO_relaxed.owl UBERON:0002347 biolink:NamedThing thoracic vertebra A thoracic vertebra endochondral element that is composed primarily of a bone tissue. RBO_relaxed.owl UBERON:0004451 biolink:NamedThing trunk or cervical vertebra A vertebra in the trunk or cervical region. Includes all cervical, thoracic and lumbar vertebrae, but excludes caudal vertebra. RBO_relaxed.owl UBERON:0011677 biolink:NamedThing trunk vertebra A vertebra in the trunk region. For tetrapods, includes lumbar and thoracic vertebrae. Excludes caudal/coccygeal vertebra, which are located posteriorly. In tetrapods this includes thoracic, lumbar and sacral vertebrae, and excludes the cervical vertebrae, which are located anteriorly. RBO_relaxed.owl UBERON:0004247 biolink:NamedThing bone of dorsum A bone that is part of the dorsal region of an animal. RBO_relaxed.owl UBERON:0002413 biolink:NamedThing cervical vertebra A vertebra that is located in the cervical region of the vertebral column. RBO_relaxed.owl UBERON:0018142 biolink:NamedThing caudal vertebra endochondral element Any vertebra endochondral element that is part of the caudal region of the vertebral column (tail or coccyx). RBO_relaxed.owl UBERON:0013503 biolink:NamedThing caudal vertebra cartilage element A caudal vertebra endochondral element that is composed primarily of cartilage tissue. RBO_relaxed.owl UBERON:0013504 biolink:NamedThing caudal vertebra pre-cartilage condensation A caudal vertebra endochondral element that is composed primarily of a pre-cartilage condensation. RBO_relaxed.owl UBERON:0001103 biolink:NamedThing diaphragm A thin musculomebranous barrier that separates the abdominal and thoracic cavities. Often used for breathing control. RBO_relaxed.owl UBERON:0008243 biolink:NamedThing upper back muscle A muscle of back that is part of a dorsal thoracic segment of trunk. RBO_relaxed.owl UBERON:0003831 biolink:NamedThing respiratory system muscle Any muscle organ that is part of a respiratory system [Automatically generated definition]. RBO_relaxed.owl UBERON:0014398 biolink:NamedThing respiratory muscle Muscle that is part of the respiratory system. RBO_relaxed.owl UBERON:0001114 biolink:NamedThing right lobe of liver The right lobe is much larger than the left; the proportion between them being as six to one. It occupies the right hypochondrium, and is separated from the left lobe on its upper surface by the falciform ligament; on its under and posterior surfaces by the left sagittal fossa; and in front by the umbilical notch. It is of a somewhat quadrilateral form, its under and posterior surfaces being marked by three fossæ: the porta and the fossæ for the gall-bladder and inferior vena cava, which separate its left part into two smaller lobes; the quadrate and caudate lobes. [WP,unvetted]. RBO_relaxed.owl UBERON:0001115 biolink:NamedThing left lobe of liver The left lobe is smaller and more flattened than the right. It is situated in the epigastric and left hypochondriac regions. Its upper surface is slightly convex and is moulded on to the diaphragm; its under surface presents the gastric impression and omental tuberosity. [WP,unvetted]. RBO_relaxed.owl UBERON:0002517 biolink:NamedThing basicranium The base of skull is the most inferior area of the skull, composed of the endocranium and lower parts of the skull roof. RBO_relaxed.owl UBERON:0003128 biolink:NamedThing cranium Upper portion of the skull that excludes the mandible (when present in the organism). RBO_relaxed.owl UBERON:0006077 biolink:NamedThing subdivision of vertebral column A collection of all skeletal elements in some subdivision of the vertebral column. RBO_relaxed.owl UBERON:0010323 biolink:NamedThing cranial skeletal system Skeletal subdivision of the head including skull (cranium plus mandible), pharyngeal and/or hyoid apparatus. RBO_relaxed.owl UBERON:0011137 biolink:NamedThing axial skeletal system Subdivision of the skeletal system which consists of the axial skeleton plus associated joints. RBO_relaxed.owl UBERON:0011158 biolink:NamedThing primary subdivision of skull The skull can be divided into two: the neurocranium and the facial skeleton. RBO_relaxed.owl UBERON:0011159 biolink:NamedThing primary subdivision of cranial skeletal system RBO_relaxed.owl UBERON:0011249 biolink:NamedThing appendicular skeletal system Subdivision of the skeletal system which consists of the appendicular skeleton plus associated joints. RBO_relaxed.owl UBERON:0012072 biolink:NamedThing palatal part of dermatocranium RBO_relaxed.owl UBERON:8600006 biolink:NamedThing visceral striated muscle tissue A striated muscle tissue that is associated with soft internal organs (viscera). RBO_relaxed.owl UBERON:0016886 biolink:NamedThing muscle tissue of terminal part of digestive tract Any muscle tissue of the distalmost portion of the digestive tract. RBO_relaxed.owl UBERON:0001138 biolink:NamedThing superior mesenteric vein In anatomy, the superior mesenteric vein (SMV) is a blood vessel that drains blood from the small intestine. At its termination behind the neck of the pancreas, the SMV combines with the splenic vein to form the hepatic portal vein. The SMV lies to the right of the similarly named artery, the superior mesenteric artery, which originates from the abdominal aorta. [WP,unvetted]. RBO_relaxed.owl UBERON:0005617 biolink:NamedThing mesenteric vein A vein that returns blood from the intestines. RBO_relaxed.owl UBERON:0001215 biolink:NamedThing inferior mesenteric vein A blood vessel that drains blood from the large intestine that usually terminates when reaching the splenic vein, which goes on to form the portal vein with the superior mesenteric vein (SMV). Anatomical variations include the IMV draining into the confluence of the SMV and splenic vein and the IMV draining in the SMV. The IMV lies to the right of the similarly name artery, the inferior mesenteric artery, which originates from the abdominal aorta. [WP,unvetted]. RBO_relaxed.owl UBERON:0001143 biolink:NamedThing hepatic vein Vein that carries blood away from the liver[ZFA]. RBO_relaxed.owl UBERON:0002017 biolink:NamedThing portal vein A vein that conducts blood from the digestive organs, spleen, pancreas, and gallbladder to the liver[BTO]. RBO_relaxed.owl UBERON:0003476 biolink:NamedThing respiratory system venous blood vessel A vein that is part of a respiratory system [Automatically generated definition]. RBO_relaxed.owl UBERON:0003477 biolink:NamedThing vein of upper lip The inferior labial vein is the vein receiving blood from the upper lip. RBO_relaxed.owl UBERON:0003478 biolink:NamedThing vein of lower lip The inferior labial vein is the vein receiving blood from the lower lip. RBO_relaxed.owl UBERON:0003481 biolink:NamedThing tail vein A vein that is part of a tail [Automatically generated definition]. RBO_relaxed.owl UBERON:0003711 biolink:NamedThing brachiocephalic vein The left and right brachiocephalic veins in the upper chest are formed by the union of each corresponding internal jugular vein and subclavian vein. This is at the level of the sternoclavicular joint. These great vessels merge to form the superior vena cava. The brachiocephalic veins are the major veins returning blood to the superior vena cava. RBO_relaxed.owl UBERON:0003713 biolink:NamedThing splenic vein A vein arising from the splenic trabecular vein in the hilum of the spleen that drains into the portal vein. RBO_relaxed.owl UBERON:0003848 biolink:NamedThing gonadal vein In medicine, gonadal vein refers to the blood vessel that carrying blood away from the gonad (testis, ovary) toward the heart. Females : ovarian vein Males : testicular vein [WP,unvetted]. RBO_relaxed.owl UBERON:0004711 biolink:NamedThing jugular vein The jugular veins are veins that bring deoxygenated blood from the head back to the heart via the superior vena cava. RBO_relaxed.owl UBERON:0005194 biolink:NamedThing thoracic vein A vein that is part of a thorax [Automatically generated definition]. RBO_relaxed.owl UBERON:0005487 biolink:NamedThing vitelline vein The paired veins that carry blood from the yolk sac back to the embryo. RBO_relaxed.owl UBERON:0006686 biolink:NamedThing spinal vein A vein that is part of a vertebral column. RBO_relaxed.owl UBERON:0009141 biolink:NamedThing craniocervical region vein A vein that is part of a craniocervical region. RBO_relaxed.owl UBERON:0010400 biolink:NamedThing spleen trabecular vein One of the veins that feed the splenic vein. RBO_relaxed.owl UBERON:0012193 biolink:NamedThing phrenic vein The veins that run parallel to the phrenic arteries which include the two superior and two inferior phrenic veins. RBO_relaxed.owl UBERON:0013126 biolink:NamedThing vein of abdomen A vein that is part of a abdomen. RBO_relaxed.owl UBERON:0013136 biolink:NamedThing vein of lip A vein that drains a lip. RBO_relaxed.owl UBERON:0013140 biolink:NamedThing systemic vein Any vein within the general circulation that transports blood back to the right atrium of the heart. RBO_relaxed.owl UBERON:0035546 biolink:NamedThing uveal vein RBO_relaxed.owl UBERON:0035550 biolink:NamedThing superficial vein Any of the veins carrying deoxygenated blood from the subcutaneous tissue layers. RBO_relaxed.owl UBERON:0035552 biolink:NamedThing deep vein A blood vessel carrying deoxygenated blood far beneath the skin usually accompanying an artery. RBO_relaxed.owl UBERON:0036268 biolink:NamedThing pelvic vein RBO_relaxed.owl UBERON:0039228 biolink:NamedThing sigmoid vein RBO_relaxed.owl UBERON:0015481 biolink:NamedThing left hepatic artery A hepatic artery that is part of a left lobe of liver. RBO_relaxed.owl UBERON:0015482 biolink:NamedThing right hepatic artery A hepatic artery that is part of a right lobe of liver. RBO_relaxed.owl UBERON:0039222 biolink:NamedThing cystic artery An artery that supplies oxygenated blood to the cystic duct. RBO_relaxed.owl UBERON:0003928 biolink:NamedThing digestive system duct A duct that is part of a digestive system [Automatically generated definition]. RBO_relaxed.owl UBERON:0004913 biolink:NamedThing hepatopancreatic ampulla A dilation of the duodenal papilla that is the opening of the juncture of the common bile duct and the main pancreatic duct. RBO_relaxed.owl UBERON:0014716 biolink:NamedThing interlobular duct A duct that is located between lobules, within the thin connective tissue septa that separate lobules. All interlobular ducts are excretory. RBO_relaxed.owl UBERON:0014719 biolink:NamedThing intralobular duct A duct that is located within a lobule, with no more connective tissue intervening between ducts and secretory units (i.e., acini or tubules) than between adjacent secretory units. Intercalated and striated ducts are intralobular. RBO_relaxed.owl UBERON:0014720 biolink:NamedThing interlobar duct A duct that is located between lobes, within conspicuous, thick connective tissue septa that separate lobes. All interlobar ducts are excretory. RBO_relaxed.owl UBERON:0035050 biolink:NamedThing excretory duct RBO_relaxed.owl UBERON:0003703 biolink:NamedThing extrahepatic bile duct Passages external to the liver for the conveyance of bile. These include the common bile duct and the common hepatic duct. RBO_relaxed.owl UBERON:0001174 biolink:NamedThing common bile duct The part of the biliary tree formed by the union of the cystic duct and the common hepatic duct. RBO_relaxed.owl UBERON:0001175 biolink:NamedThing common hepatic duct Predominantly extrahepatic bile duct which is formed by the junction of the right and left hepatic ducts, which are predominantly intrahepatic, and, in turn, joins the cystic duct to form the common bile duct[GAID]. The common hepatic duct is the duct formed by the convergence of the right hepatic duct (which drains bile from the right functional lobe of the liver) and the left hepatic duct (which drains bile from the left functional lobe of the liver). The common hepatic duct then joins the cystic duct coming from the gallbladder to form the common bile duct[WP]. RBO_relaxed.owl UBERON:0001176 biolink:NamedThing right hepatic duct The duct that drains bile from the right half of the liver and joins the left hepatic duct to form the common hepatic duct. RBO_relaxed.owl UBERON:0001177 biolink:NamedThing left hepatic duct The duct that drains bile from the left half of the liver and joins the right hepatic duct to form the common hepatic duct. RBO_relaxed.owl UBERON:0001161 biolink:NamedThing body of stomach The body of stomach is the part of the stomach that lies between the fundus above and the pyloric antrum below; its boundaries are poorly defined[GO]. RBO_relaxed.owl UBERON:0008858 biolink:NamedThing pyloric canal The short narrow part of the stomach extending from the pyloric antrum to the pyloric sphincter. RBO_relaxed.owl UBERON:0001170 biolink:NamedThing mesentery of small intestine The peritoneum responsible for connecting the jejunum and ileum (parts of the small intestine) to the back wall of the abdomen. Between the two sheets of peritoneum are blood vessels, lymph vessels, and nerves. This allows these parts of the small intestine to move relatively freely within the abdominopelvic cavity. The brain, however, cannot map sensation accurately, so sensation is usually referred to the midline, an example of referred pain[WP]. RBO_relaxed.owl UBERON:0003281 biolink:NamedThing mesentery of stomach The portion of the primitive mesentery that encloses the stomach; from its dorsal sheet, the greater omentum develops, and from its ventral sheet, the lesser omentum. RBO_relaxed.owl UBERON:0003282 biolink:NamedThing mesentery of heart A mesentery that surrounds the heart. RBO_relaxed.owl UBERON:0003283 biolink:NamedThing mesentery of oesophagus A mesentery that is part of a esophagus [Automatically generated definition]. RBO_relaxed.owl UBERON:0003284 biolink:NamedThing mesentery of midgut A mesentery that is part of a midgut [Automatically generated definition]. RBO_relaxed.owl UBERON:0003393 biolink:NamedThing mesentery of urinary system A mesentery that is part of a urinary system [Automatically generated definition]. RBO_relaxed.owl UBERON:0003394 biolink:NamedThing mesentery of hindgut A mesentery that is part of a hindgut [Automatically generated definition]. RBO_relaxed.owl UBERON:0003395 biolink:NamedThing mesentery of rectum A mesentery that is part of a rectum [Automatically generated definition]. RBO_relaxed.owl UBERON:0003396 biolink:NamedThing mesentery of colon A mesentery that is part of a colon [Automatically generated definition]. RBO_relaxed.owl UBERON:0003397 biolink:NamedThing mesentery of duodenum A mesentery that is part of a duodenum [Automatically generated definition]. RBO_relaxed.owl UBERON:0004854 biolink:NamedThing gastrointestinal system mesentery A mesentery that is part of a digestive system [Automatically generated definition]. RBO_relaxed.owl UBERON:0007826 biolink:NamedThing peritoneal mesentery Mesentery that is located in the peritoneum. RBO_relaxed.owl UBERON:0009483 biolink:NamedThing mesentery of foregut-midgut junction A mesentery that is part of a foregut-midgut junction. RBO_relaxed.owl UBERON:0009664 biolink:NamedThing gut mesentery RBO_relaxed.owl UBERON:0011858 biolink:NamedThing acinus of exocrine gland An acinus that is part of a exocrine gland. RBO_relaxed.owl UBERON:0013232 biolink:NamedThing serous acinus The secretory unit of a serous gland. The acinar portion is composed of serous secreting cells. RBO_relaxed.owl UBERON:0014717 biolink:NamedThing mucous acinus The secretory unit of a mucous gland. The acinar portion is composed of mucous secreting cells. RBO_relaxed.owl UBERON:0002425 biolink:NamedThing visceral serous pericardium Visceral serous membrane which is continuous with the parietal serous pericardium and is attached to the myocardium[FMA]. RBO_relaxed.owl UBERON:0001190 biolink:NamedThing ovarian artery An artery that supplies an ovary. RBO_relaxed.owl UBERON:0001193 biolink:NamedThing hepatic artery An artery that supplies the liver. RBO_relaxed.owl UBERON:0001194 biolink:NamedThing splenic artery An artery that supplies the spleen. RBO_relaxed.owl UBERON:0001612 biolink:NamedThing facial artery A branch of the external carotid artery that supplies structures of the face. [WP,unvetted]. RBO_relaxed.owl UBERON:0001616 biolink:NamedThing maxillary artery An artery that supplies deep structures of the face. It comes just out behind the neck of the mandible. [WP,unvetted]. RBO_relaxed.owl UBERON:0001651 biolink:NamedThing right pulmonary artery The pulmonary artery that supplies the right lung. RBO_relaxed.owl UBERON:0001652 biolink:NamedThing left pulmonary artery The pulmonary artery that supplies the left lung. RBO_relaxed.owl UBERON:0002333 biolink:NamedThing pulmonary trunk An arterial trunk which is continuous with the heart and branches into the pulmonary arteries. RBO_relaxed.owl UBERON:0002457 biolink:NamedThing intersomitic artery The small branching sprouts of the dorsal aorta that grow across the medial surface of the somite, turn right angles to grow over that surface and then fuse with other sprouts and form the vertebral arteries adjacent to the neural tube; the intersomitic arteries supply the body wall and persist in the adult as the posterior intercostal, subcostal and the lumbar arteries. RBO_relaxed.owl UBERON:0002458 biolink:NamedThing spinal artery Arteries that supply the spinal cord. RBO_relaxed.owl UBERON:0003086 biolink:NamedThing caudal artery Extension of the dorsal aorta in the tail. RBO_relaxed.owl UBERON:0003469 biolink:NamedThing respiratory system artery An artery that is part of a respiratory system [Automatically generated definition]. RBO_relaxed.owl UBERON:0003470 biolink:NamedThing artery of upper lip The superior labial artery (superior labial branch of facial artery) is larger and more tortuous than the inferior labial artery. It follows a similar course along the edge of the upper lip, lying between the mucous membrane and the Orbicularis oris, and anastomoses with the artery of the opposite side. It supplies the upper lip, and gives off in its course two or three vessels which ascend to the nose; a septal branch ramifies on the nasal septum as far as the point of the nose, and an alar branch supplies the ala of the nose. RBO_relaxed.owl UBERON:0003471 biolink:NamedThing artery of lower lip The inferior labial artery (inferior labial branch of facial artery) arises near the angle of the mouth; it passes upward and forward beneath the Triangularis and, penetrating the Orbicularis oris, runs in a tortuous course along the edge of the lower lip between this muscle and the mucous membrane. It supplies the labial glands, the mucous membrane, and the muscles of the lower lip; and anastomoses with the artery of the opposite side, and with the mental branch of the inferior alveolar artery. RBO_relaxed.owl UBERON:0004573 biolink:NamedThing systemic artery An artery of the systemic circulation, which is the part of the cardiovascular system which carries oxygenated blood away from the heart, to the body, and returns deoxygenated blood back to the heart. RBO_relaxed.owl UBERON:0004688 biolink:NamedThing costo-cervical trunk The costocervical trunk arises from the upper and back part of the subclavian artery, behind the scalenus anterior on the right side, and medial to that muscle on the left side. Passing backward, it splits into the deep cervical artery and the supreme intercostal artery (or the Highest intercostal artery), which descends behind the pleura in front of the necks of the first and second ribs, and anastomoses with the first aortic intercostal (3rd posterior intercostal artery). As it crosses the neck of the first rib it lies medial to the anterior division of the first thoracic nerve, and lateral to the first thoracic ganglion of the sympathetic trunk. In the first intercostal space, it gives off a branch which is distributed in a manner similar to the distribution of the aortic intercostals. The branch for the second intercostal space usually joins with one from the highest aortic intercostal artery. This branch is not constant, but is more commonly found on the right side; when absent, its place is supplied by an intercostal branch from the aorta. Each intercostal gives off a posterior branch which goes to the posterior vertebral muscles, and sends a small spinal branch through the corresponding intervertebral foramen to the medulla spinalis and its membranes. [WP,unvetted]. RBO_relaxed.owl UBERON:0005616 biolink:NamedThing mesenteric artery Arteries which arise from the abdominal aorta and distribute to most of the intestines. RBO_relaxed.owl UBERON:0006002 biolink:NamedThing vitelline artery The paired arteries that carry blood to the yolk sac from the dorsal aorta. RBO_relaxed.owl UBERON:0006347 biolink:NamedThing communicating artery An artery that connects two larger arteries. RBO_relaxed.owl UBERON:0009657 biolink:NamedThing artery of lip RBO_relaxed.owl UBERON:0010399 biolink:NamedThing spleen trabecular artery One of the branches of the splenic artery[MP]. RBO_relaxed.owl UBERON:0012254 biolink:NamedThing abdominal aorta artery An artery that originates from the abdominal aorta. RBO_relaxed.owl UBERON:0035039 biolink:NamedThing rectal artery RBO_relaxed.owl UBERON:0035398 biolink:NamedThing branch of external carotid artery RBO_relaxed.owl UBERON:0035539 biolink:NamedThing esophageal artery Any of several arteries that arise from the aorta and supply blood to the esophagus. RBO_relaxed.owl UBERON:0035548 biolink:NamedThing colic artery RBO_relaxed.owl UBERON:0039261 biolink:NamedThing pancreatic artery RBO_relaxed.owl UBERON:0001200 biolink:NamedThing submucosa of stomach The fibrous connective tissue layer beneath the stomach mucosa. RBO_relaxed.owl UBERON:0001205 biolink:NamedThing submucosa of small intestine Submucosal tissue in the small intestines. RBO_relaxed.owl UBERON:0001208 biolink:NamedThing submucosa of large intestine A submucosa that is part of a large intestine [Automatically generated definition]. RBO_relaxed.owl UBERON:0001972 biolink:NamedThing submucosa of esophagus A submucosa that is part of a esophagus [Automatically generated definition]. RBO_relaxed.owl UBERON:0003330 biolink:NamedThing submucosa of rectum The submucous layer of the wall of the rectum. RBO_relaxed.owl UBERON:0003331 biolink:NamedThing submucosa of colon A submucosa that is part of a colon [Automatically generated definition]. RBO_relaxed.owl UBERON:0003332 biolink:NamedThing submucosa of duodenum A submucosa that is part of a duodenum [Automatically generated definition]. RBO_relaxed.owl UBERON:0004777 biolink:NamedThing respiratory system submucosa A submucosa that is part of a respiratory system [Automatically generated definition]. RBO_relaxed.owl UBERON:0004924 biolink:NamedThing submucosa of pharynx The tissue underlying the tunica mucosa of the pharynx. RBO_relaxed.owl UBERON:0004926 biolink:NamedThing submucosa of cystic duct A submucosa that is part of a cystic duct [Automatically generated definition]. RBO_relaxed.owl UBERON:0004932 biolink:NamedThing submucosa of sigmoid colon A submucosa that is part of a sigmoid colon [Automatically generated definition]. RBO_relaxed.owl UBERON:0004934 biolink:NamedThing submucosa of body of stomach A submucosa that is part of a body of stomach [Automatically generated definition]. RBO_relaxed.owl UBERON:0004936 biolink:NamedThing submucosa of pyloric antrum A submucosa that is part of a pyloric antrum [Automatically generated definition]. RBO_relaxed.owl UBERON:0004937 biolink:NamedThing submucosa of pylorus A submucosa that is part of a pylorus [Automatically generated definition]. RBO_relaxed.owl UBERON:0004939 biolink:NamedThing submucosa of common bile duct A submucosa that is part of a common bile duct [Automatically generated definition]. RBO_relaxed.owl UBERON:0004940 biolink:NamedThing submucosa of common hepatic duct A submucosa that is part of a common hepatic duct [Automatically generated definition]. RBO_relaxed.owl UBERON:0004941 biolink:NamedThing submucosa of right hepatic duct A submucosa that is part of a right hepatic duct [Automatically generated definition]. RBO_relaxed.owl UBERON:0004942 biolink:NamedThing submucosa of left hepatic duct A submucosa that is part of a left hepatic duct [Automatically generated definition]. RBO_relaxed.owl UBERON:0009566 biolink:NamedThing intestinal submucosa A submucosa that is part of a intestine. RBO_relaxed.owl UBERON:0012482 biolink:NamedThing submucosa of cloaca A submucosa that is part of a cloaca [Automatically generated definition]. RBO_relaxed.owl UBERON:0018257 biolink:NamedThing submucosa of digestive tract Any portion of submucosa that lines the digestive tract. RBO_relaxed.owl UBERON:0001202 biolink:NamedThing pyloric sphincter A strong ring of smooth muscle at the end of the pyloric canal which lets food pass from the stomach to the duodenum. It receives sympathetic innervation from the celiac ganglion[WP]. RBO_relaxed.owl UBERON:0004916 biolink:NamedThing anal sphincter A sphincter muscle that is part of a anal region. RBO_relaxed.owl UBERON:0007521 biolink:NamedThing smooth muscle sphincter A ring of smooth muscle cells whose contraction closes the opening of the ring. RBO_relaxed.owl UBERON:0007522 biolink:NamedThing striated muscle sphincter A ring of striated muscle cells whose contraction closes the opening of the ring. RBO_relaxed.owl UBERON:0007652 biolink:NamedThing esophageal sphincter A sphincter that is part of an esophagus. RBO_relaxed.owl UBERON:0013501 biolink:NamedThing cloacal sphincter A sphincter muscle that is part of a cloaca. RBO_relaxed.owl UBERON:0011148 biolink:NamedThing submucosal gland Gland of the lamina epithelialis mucosae which perforate the lamina muscularis, with their adenomeres located in the submucosal connective tissue. RBO_relaxed.owl UBERON:0001246 biolink:NamedThing interlobular bile duct The canals that carry bile in the liver between the intralobular ducts and the biliary ductules; interlobular bile ducts are part of the interlobular portal triad. RBO_relaxed.owl UBERON:0001282 biolink:NamedThing intralobular bile duct The tubules located between the bile canaliculi and interlobular bile ducts near the outer edge of a classic liver lobule. RBO_relaxed.owl UBERON:8600012 biolink:NamedThing submucosal gland acinus A spherical or tubular structure in a submucosal gland that produces and secretes mucus and other substances into the ducts leading to the surface epithelium. RBO_relaxed.owl UBERON:0017672 biolink:NamedThing abdominal viscera A viscus that is part of a abdomen. RBO_relaxed.owl UBERON:0035820 biolink:NamedThing peritoneal sac A serous sac that is the aggregate of the peritoneum and the peritoneal cavity, located in the abdominal cavity. RBO_relaxed.owl UBERON:0005945 biolink:NamedThing neurocranial trabecula RBO_relaxed.owl UBERON:0006929 biolink:NamedThing glandular columnar epithelium Simple columnar epithelium that constitutes the secretory part of a gland. Examples: epithelium of stomach, luminal epithelium of lactiferous duct.[FMA]. RBO_relaxed.owl UBERON:0007592 biolink:NamedThing ciliated columnar epithelium Simple columnar epithelium in which the luminal side of the cells bears cilia. Examples: epithelium of trachea, epithelium of uterine tube.[FMA]. RBO_relaxed.owl UBERON:0010498 biolink:NamedThing pseudostratified columnar epithelium A simple columnar epithelium that looks stratified but is not, because its cells are arranged with their nuclei at different levels. RBO_relaxed.owl UBERON:0003112 biolink:NamedThing olfactory region Anatomical cluster that is located in the anterior region of the cranium and provides structural support for the olfactory organ. RBO_relaxed.owl UBERON:0005902 biolink:NamedThing occipital region Anatomical cluster that is located in the posterior region of the cranium and forms the margin of the foramen magnum and occipital condyles. RBO_relaxed.owl UBERON:0008814 biolink:NamedThing pharyngeal arch system A transient embryonic complex that comprises the pharyngeal arches, bulges of tissues of mesoderm and neural crest derivation through which pass nerves and pharyngeal arch arteries. The arches are separated internally by pharyngeal pouches, evaginations of foregut endoderm, and externally by pharyngeal clefts, invaginations of surface ectoderm. The development of the system ends when the stucture it contributes to are forming, which may include (depending on species) the thymus, thyroid, parathyroids, maxilla, mandible, aortic arch, cardiac outflow tract, external and middle ear[GO,modified]. RBO_relaxed.owl UBERON:0035639 biolink:NamedThing ocular adnexa The parts of the orbital region that are outside of the the eyeball, including the lacrimal apparatus, the extraocular muscles and the eyelids, eyelashes, eyebrows and the conjunctiva. RBO_relaxed.owl UBERON:0001978 biolink:NamedThing parenchyma of pancreas RBO_relaxed.owl UBERON:0005221 biolink:NamedThing liver right lobe parenchyma A parenchyma that is part of a right lobe of liver [Automatically generated definition]. RBO_relaxed.owl UBERON:0005222 biolink:NamedThing liver left lobe parenchyma A parenchyma that is part of a left lobe of liver [Automatically generated definition]. RBO_relaxed.owl UBERON:0001325 biolink:NamedThing muscle of pelvis Muscle (organ) which is a part of the pelvis. Examples: levator ani,. RBO_relaxed.owl UBERON:0003833 biolink:NamedThing abdominal segment muscle A muscle organ that is part of an abdominal segment of trunk [Automatically generated definition]. RBO_relaxed.owl UBERON:0002378 biolink:NamedThing muscle of abdomen Muscle (organ) which is a part of the abdomen. Examples: external oblique, rectus abdominis. RBO_relaxed.owl UBERON:0014892 biolink:NamedThing skeletal muscle organ, vertebrate A muscle organ that consists of skeletal muscle tissue ensheathed in epimysium, that develops from myotome and that is innervated by some somatic motor neuron. Skeletal muscles are typically attached (via a tendon) to a bone but there are exceptions (e.g. intrinsic tongue muscles). RBO_relaxed.owl UBERON:0001497 biolink:NamedThing muscle of pelvic girdle Any muscle organ that is part of a pelvic girdle [Automatically generated definition]. RBO_relaxed.owl UBERON:0002324 biolink:NamedThing muscle of back Any muscle organ that is part of a back [Automatically generated definition]. RBO_relaxed.owl UBERON:0002377 biolink:NamedThing muscle of neck Any muscle that is part of the cervical (neck) region. RBO_relaxed.owl UBERON:0003665 biolink:NamedThing post-anal tail muscle A muscle organ that attaches to a tail vertebra [Automatically generated definition]. RBO_relaxed.owl UBERON:0003897 biolink:NamedThing axial muscle One of the skeletal muscles of the head and neck, spine, and ribs. RBO_relaxed.owl UBERON:0004518 biolink:NamedThing muscle of vertebral column A muscle that is attached to a vertebra of the vertebral column. RBO_relaxed.owl UBERON:0008196 biolink:NamedThing muscle of pectoral girdle Any muscle organ that is part of a pectoral girdle region. RBO_relaxed.owl UBERON:0010890 biolink:NamedThing pelvic complex muscle Muscles of the pelvic girdle, hindlimb or pelvic fin. RBO_relaxed.owl UBERON:0010891 biolink:NamedThing pectoral complex muscle A muscle of a pectoral girdle, pectoral fin or anterior limb. RBO_relaxed.owl UBERON:0010959 biolink:NamedThing craniocervical muscle Any muscle organ that is part of either the head or the neck. RBO_relaxed.owl UBERON:0014794 biolink:NamedThing pectoral appendage muscle Any muscle organ that is part of a pectoral appendage (forelimb or pectoral fin). RBO_relaxed.owl UBERON:0014795 biolink:NamedThing pelvic appendage muscle Any muscle organ that is part of a pelvic appendage (hindlimb or pelvic fin). RBO_relaxed.owl UBERON:0002408 biolink:NamedThing parietal serous pericardium Parietal serous membrane which is part of the pericardium and forms the outer layer of the pericardial sac. RBO_relaxed.owl UBERON:0004089 biolink:NamedThing midface The middle of the face including the nose and its associated bony structures[MW]. RBO_relaxed.owl UBERON:0010363 biolink:NamedThing endochondral element A skeletal element that has the potential to participate in endochondral ossification, and may participate in intramembranous ossification. RBO_relaxed.owl UBERON:0010522 biolink:NamedThing replacement element Skeletal element that forms as a replacement or substitution of another element or tissue. RBO_relaxed.owl UBERON:0001515 biolink:NamedThing thoracic aorta The part of the aorta that extends from the origin at the heart to the diaphragm, and from which arises numerous branches that supply oxygenated blood to the chest cage and the organs within the chest. RBO_relaxed.owl UBERON:0001508 biolink:NamedThing arch of aorta The convex portion of the aorta between the ascending and descending parts of the aorta; branches from it include the brachiocephalic trunk, the left common carotid artery, and the left subclavian artery; the brachiocephalic trunk further splits to form the right subclavian artery and the right common carotid artery. RBO_relaxed.owl UBERON:0001516 biolink:NamedThing abdominal aorta Abdominal part of aorta: the distal part of the descending aorta, which is the continuation of the thoracic part and gives rise to the inferior phrenic, lumbar, median sacral, superior and inferior mesenteric, middle suprarenal, renal, and testicular or ovarian arteries, and celiac trunk[BTO]. The abdominal aorta is the largest artery in the abdominal cavity. As part of the aorta, it is a direct continuation of descending aorta(of the thorax). [WP,unvetted]. RBO_relaxed.owl UBERON:0001530 biolink:NamedThing common carotid artery plus branches A bilaterally paired branched artery that originates from the aortic arches and divides into and includes as parts the internal and external carotid arteries[cjm]. RBO_relaxed.owl UBERON:0002040 biolink:NamedThing bronchial artery A systemic artery that supplies the lung with with oxygenated blood. RBO_relaxed.owl UBERON:0002057 biolink:NamedThing phrenic artery An artery that supplies the diaphragm. RBO_relaxed.owl UBERON:0005436 biolink:NamedThing common hepatic artery In anatomy, the common hepatic artery is a short blood vessel that supplies oxygenated blood to the liver, pylorus (a part of the stomach), duodenum (a part of the small intestine) and pancreas. It arises from the celiac artery and has the following branches:. RBO_relaxed.owl UBERON:0010192 biolink:NamedThing genital artery One of the laterally paired arteries that supply the gonads. RBO_relaxed.owl UBERON:0001586 biolink:NamedThing internal jugular vein One of two jugular veins that collect the blood from the brain, the superficial parts of the face, and the neck. [WP,unvetted]. RBO_relaxed.owl UBERON:0004234 biolink:NamedThing iris smooth muscle A portion of smooth muscle tissue that is part of a iris [Automatically generated definition]. RBO_relaxed.owl UBERON:0001606 biolink:NamedThing muscle of iris RBO_relaxed.owl UBERON:0004253 biolink:NamedThing skin muscle Any muscle organ that is part of a skin of body [Automatically generated definition]. RBO_relaxed.owl UBERON:0018544 biolink:NamedThing trigeminal nerve muscle Muscle innervated by the trigeminal nerve (Cranial Nerve V). RBO_relaxed.owl UBERON:0001608 biolink:NamedThing dilatator pupillae A smooth muscle of the eye, running radially in the iris that functions as a dilator. [WP,unvetted]. RBO_relaxed.owl UBERON:0003920 biolink:NamedThing venous blood vessel A blood vessel that carries blood from the capillaries toward the heart. RBO_relaxed.owl UBERON:0001640 biolink:NamedThing celiac artery The first major branch of the abdominal aorta. RBO_relaxed.owl UBERON:0001653 biolink:NamedThing facial vein The anterior facial vein (facial vein) commences at the side of the root of the nose, and is a direct continuation of the angular vein where it also receives a small nasal branch. It lies behind the facial artery and follows a less tortuous course. It receives blood from the external palatine vein before it either joins the anterior branch of the retromandibular vein to form the common facial vein, or drains directly into the internal jugular vein. [WP,unvetted]. RBO_relaxed.owl UBERON:0003496 biolink:NamedThing head blood vessel A blood vessel that is part of a head [Automatically generated definition]. RBO_relaxed.owl UBERON:0001714 biolink:NamedThing cranial ganglion The groups of nerve cell bodies associated with the twelve cranial nerves. RBO_relaxed.owl UBERON:0001800 biolink:NamedThing sensory ganglion The clusters of neurons in the somatic peripheral nervous system which contain the cell bodies of sensory nerve axons, interneurons and non-neuronal supporting cells. RBO_relaxed.owl UBERON:0001677 biolink:NamedThing sphenoid bone An unpaired bone situated at the base of the skull in front of the temporal bone and basilar part of the occipital bone. The sphenoid bone is one of the seven bones that articulate to form the orbit. Its shape somewhat resembles that of a butterfly or bat with its wings extended. RBO_relaxed.owl UBERON:0008193 biolink:NamedThing pneumatized bone A bone that is hollow or contains many air cells, such as the mastoid process of the temporal bone[TMD]. RBO_relaxed.owl UBERON:0009193 biolink:NamedThing sphenoid cartilage element A sphenoid endochondral element that is composed primarily of cartilage tissue. RBO_relaxed.owl UBERON:0002091 biolink:NamedThing appendicular skeleton Subdivision of skeleton which which consists of all the skeletal elements in in the pectoral and pelvic appendage complexes[cjm]. RBO_relaxed.owl UBERON:0007272 biolink:NamedThing pectoral appendage skeleton Skeletal subdivision consisting of the anterior appendicular limb skeleton, excluding the pectoral girdle. RBO_relaxed.owl UBERON:0007273 biolink:NamedThing pelvic appendage skeleton The collection of all skeletal elements in a pelvic appendage region. RBO_relaxed.owl UBERON:0007831 biolink:NamedThing pectoral girdle skeleton A subdivision of a limb or fin skeleton consisting of bones which connects the upper limb or fin to the axial skeleton on each side. It consists of the clavicle and scapula in humans and, in those species with three bones in the pectoral girdle, the coracoid. Some mammalian species (e.g. the dog and the horse) have only the scapula. In humans, the only joints between the shoulder girdle and axial skeleton are the sternoclavicular joints on each side. No joint exists between each scapula and the rib cage; instead the muscular connection between the two permits relatively great mobility of the shoulder girdle in relation to the pelvic girdle. In those species having only the scapula, no joint exists between the forelimb and the thorax, the only attachment being muscular[WP]. Examples: There are only two instances, right and left pectoral girdle skeletons. RBO_relaxed.owl UBERON:0010362 biolink:NamedThing endoskeleton Skeletal subdivision that undergoes indirect development and includes elements that develop as a replacement or substitution of other elements or tissues. RBO_relaxed.owl UBERON:0010364 biolink:NamedThing dermal skeleton Skeletal subdivision that undergoes direct development and includes elements that either develop in association with the basement membrane of the ectoderm or are homologous with such elements; includes dermatocranium, components of the appendicular skeleton, teeth and tooth-like elements of the oropharynx, and integumentary elements. RBO_relaxed.owl UBERON:0010719 biolink:NamedThing girdle skeleton The subdivision of the skeleton of either the pectoral or pelvic girdle. RBO_relaxed.owl UBERON:0012475 biolink:NamedThing skeleton of pectoral complex The collection of all skeletal elements in a pectoral complex - i.e. the combination of free limb or fin plus pectoral girdle. RBO_relaxed.owl UBERON:0012476 biolink:NamedThing skeleton of pelvic complex The collection of all skeletal elements in a pelvic complex - i.e. the combination of free limb or fin plus pelvic girdle. RBO_relaxed.owl UBERON:0014477 biolink:NamedThing thoracic skeleton Subdivision of skeletal system that consists of all skeletal elements in the thoracic region of the trunk. In most vertebrates this is the rib cage and sternum. RBO_relaxed.owl UBERON:0001805 biolink:NamedThing autonomic ganglion Ganglion that has dendrites that form a junction between autonomic nerves originating from the central nervous system and autonomic nerves innervating their target organs in the periphery. There are two subtypes, sympathetic ganglion and parasympathetic ganglion. RBO_relaxed.owl UBERON:0003338 biolink:NamedThing ganglion of peripheral nervous system A spatially aggregated collection of nerve cell bodies in the PNS, consisting of one or more subpopulations that share cell type, chemical phenotype, and connections. (CUMBO). RBO_relaxed.owl UBERON:0007134 biolink:NamedThing trunk ganglion Ganglion which is located in the trunk. RBO_relaxed.owl UBERON:0009758 biolink:NamedThing abdominal ganglion A ganglion that is part of a abdominal segment of trunk. RBO_relaxed.owl UBERON:0010294 biolink:NamedThing scleral endothelium An endothelium that is part of a sclera. RBO_relaxed.owl UBERON:0010295 biolink:NamedThing substantia propria of sclera A stroma that is part of a sclera. RBO_relaxed.owl UBERON:0018234 biolink:NamedThing stroma of pancreas A stroma that is part of a pancreas. RBO_relaxed.owl UBERON:0006930 biolink:NamedThing glandular cuboidal epithelium RBO_relaxed.owl UBERON:0001833 biolink:NamedThing lip One of the two fleshy folds which surround the opening of the mouth. RBO_relaxed.owl UBERON:0004357 biolink:NamedThing paired limb/fin bud An outgrowth on the lateral trunk of the embryo that develops into a limb or paired fin. The limb/fin bud is divided into ectoderm and mesenchyme[cjm, modified from MP]. RBO_relaxed.owl UBERON:0014776 biolink:NamedThing midbrain neuromere A neuromere that is part of the presumptive midbrain. RBO_relaxed.owl UBERON:0014777 biolink:NamedThing spinal neuromere A neuromere that is part of the presumptive spinal cord. RBO_relaxed.owl UBERON:0005290 biolink:NamedThing myelencephalon The posterior part of the developing vertebrate hindbrain or the corresponding part of the adult brain composed of the medulla oblongata and a portion of the fourth ventricle; as well as the glossopharyngeal nerve (CN IX), vagus nerve (CN X), accessory nerve (CN XI), hypoglossal nerve (CN XII), and a portion of the vestibulocochlear nerve (CN VIII).[BTO,WP]. RBO_relaxed.owl UBERON:0001916 biolink:NamedThing endothelium of arteriole An endothelium that is part of an arteriole [Automatically generated definition]. RBO_relaxed.owl UBERON:0001918 biolink:NamedThing endothelium of venule An endothelium that is part of a venule [Automatically generated definition]. RBO_relaxed.owl UBERON:0001919 biolink:NamedThing endothelium of vein An endothelium that is part of a vein [Automatically generated definition]. RBO_relaxed.owl UBERON:0004698 biolink:NamedThing vena cava endothelium An endothelium that is part of a vena cava [Automatically generated definition]. RBO_relaxed.owl UBERON:0004699 biolink:NamedThing outflow tract endothelium An endothelium that is part of a outflow tract [Automatically generated definition]. RBO_relaxed.owl UBERON:0004700 biolink:NamedThing arterial system endothelium An endothelium that is part of an arterial system [Automatically generated definition]. RBO_relaxed.owl UBERON:0004701 biolink:NamedThing venous system endothelium An endothelium that is part of a venous system [Automatically generated definition]. RBO_relaxed.owl UBERON:0004851 biolink:NamedThing aorta endothelium The thin layer of flat cells that line the aorta and form a barrier between circulating blood in the lumen and the rest of the vessel wall. RBO_relaxed.owl UBERON:0004852 biolink:NamedThing cardiovascular system endothelium An endothelium that is part of the cardiovascular system. RBO_relaxed.owl UBERON:0005316 biolink:NamedThing endocardial endothelium The endothelial lining of the endocardium. RBO_relaxed.owl UBERON:0008307 biolink:NamedThing heart endothelium An endothelium that is part of a heart [Automatically generated definition]. RBO_relaxed.owl UBERON:0019189 biolink:NamedThing carotid artery endothelium RBO_relaxed.owl UBERON:0004702 biolink:NamedThing respiratory system blood vessel endothelium A blood vessel endothelium that is part of a respiratory system [Automatically generated definition]. RBO_relaxed.owl UBERON:2005260 biolink:NamedThing fenestrated capillary Capillary that has pores in the endothelial cells (60-80 nm in diameter) that are spanned by a diaphragm of radially oriented fibrils and allow small molecules and limited amounts of protein to diffuse. RBO_relaxed.owl UBERON:8410081 biolink:NamedThing blood microvessel Any of the smallest blood vessels where blood circulates within organ tissues. Microvessels include terminal arterioles, metarterioles, capillaries, and venules (but exclude lymphatic capillaries). Arterioles carry oxygenated blood to the capillaries, and blood flows out of the capillaries through venules into veins. RBO_relaxed.owl UBERON:0001982 biolink:NamedThing capillary Any of the smallest blood vessels connecting arterioles with venules. RBO_relaxed.owl UBERON:0003497 biolink:NamedThing abdomen blood vessel A blood vessel that is part of an abdomen [Automatically generated definition]. RBO_relaxed.owl UBERON:0003498 biolink:NamedThing heart blood vessel A blood vessel that is part of a heart [Automatically generated definition]. RBO_relaxed.owl UBERON:0003502 biolink:NamedThing neck blood vessel A blood vessel that is part of a neck [Automatically generated definition]. RBO_relaxed.owl UBERON:0003504 biolink:NamedThing respiratory system blood vessel A blood vessel that is part of a respiratory system [Automatically generated definition]. RBO_relaxed.owl UBERON:0003513 biolink:NamedThing trunk blood vessel A blood vessel that is part of a trunk [Automatically generated definition]. RBO_relaxed.owl UBERON:0003520 biolink:NamedThing pelvis blood vessel A blood vessel that is part of a pelvis [Automatically generated definition]. RBO_relaxed.owl UBERON:0003524 biolink:NamedThing tail blood vessel A blood vessel that is part of a tail [Automatically generated definition]. RBO_relaxed.owl UBERON:0003834 biolink:NamedThing thoracic segment blood vessel A blood vessel that is part of a thorax [Automatically generated definition]. RBO_relaxed.owl UBERON:0003835 biolink:NamedThing abdominal segment blood vessel A blood vessel that is part of an abdominal segment of trunk [Automatically generated definition]. RBO_relaxed.owl UBERON:0004258 biolink:NamedThing back blood vessel A blood vessel that is part of a back [Automatically generated definition]. RBO_relaxed.owl UBERON:0004365 biolink:NamedThing vitelline blood vessel Blood vessel that is connected to the yolk sac. RBO_relaxed.owl UBERON:0007300 biolink:NamedThing pectoral appendage blood vessel A blood vessel that is part of a pectoral appendage. RBO_relaxed.owl UBERON:0007301 biolink:NamedThing appendage blood vessel A blood vessel that is part of a limb/fin. RBO_relaxed.owl UBERON:0014907 biolink:NamedThing intersomitic vessel One of the primary blood vessel sprouts that originate from the dorsal aorta and posterior cardinal vein and align dorsoventrally at the myotomal boundaries between somites. RBO_relaxed.owl UBERON:3010200 biolink:NamedThing vasculature of respiratory integument Blood vessels in respiratory skin. RBO_relaxed.owl UBERON:0001988 biolink:NamedThing feces Portion of semisolid bodily waste discharged through the anus[MW,modified]. RBO_relaxed.owl UBERON:0034945 biolink:NamedThing excreted gas Any gaseous product of an excretory process. RBO_relaxed.owl UBERON:0002047 biolink:NamedThing pontine raphe nucleus The pontine raphe nucleus is one of the raphe nuclei. It is located in the pontine tegmentum. [WP,unvetted]. RBO_relaxed.owl UBERON:0007635 biolink:NamedThing nucleus of medulla oblongata A neural nucleus that is part of a medulla oblongata. RBO_relaxed.owl UBERON:0006612 biolink:NamedThing shell A rigid covering that envelops an object. RBO_relaxed.owl UBERON:0007214 biolink:NamedThing mesenchyme derived from trunk neural crest Mesenchyme that develops_from a trunk neural crest. RBO_relaxed.owl UBERON:0009618 biolink:NamedThing trunk paraxial mesoderm RBO_relaxed.owl UBERON:0007213 biolink:NamedThing mesenchyme derived from head neural crest Mesenchyme that develops_from a cranial neural crest. RBO_relaxed.owl UBERON:0003218 biolink:NamedThing ovary septum Septum that divides the ovary, the basal portion of a carpel or group of fused carpels, that encloses the ovule(s)[GO]. RBO_relaxed.owl UBERON:0002104 biolink:NamedThing visual system The sensory system subserving the sense of vision. RBO_relaxed.owl UBERON:0002105 biolink:NamedThing vestibulo-auditory system Sensory system responsible for the perception of spatial orientation and auditory stimuli. RBO_relaxed.owl UBERON:0005726 biolink:NamedThing chemosensory system RBO_relaxed.owl UBERON:0007037 biolink:NamedThing mechanosensory system RBO_relaxed.owl UBERON:0016490 biolink:NamedThing auditory system Is the sensory system for the sense of hearing. RBO_relaxed.owl UBERON:0018707 biolink:NamedThing bladder organ A membranous sac in animals that serves as the receptacle of a liquid or contains gas. RBO_relaxed.owl UBERON:0002111 biolink:NamedThing artery smooth muscle tissue A portion of smooth muscle tissue that is part of an artery [Automatically generated definition]. RBO_relaxed.owl UBERON:0002112 biolink:NamedThing smooth muscle of esophagus A portion of smooth muscle tissue that is part of a esophagus [Automatically generated definition]. RBO_relaxed.owl UBERON:0004220 biolink:NamedThing large intestine smooth muscle A portion of smooth muscle tissue that is part of a large intestine [Automatically generated definition]. RBO_relaxed.owl UBERON:0004221 biolink:NamedThing intestine smooth muscle A portion of smooth muscle tissue that is part of a intestine [Automatically generated definition]. RBO_relaxed.owl UBERON:0004222 biolink:NamedThing stomach smooth muscle A portion of smooth muscle tissue that is part of a stomach [Automatically generated definition]. RBO_relaxed.owl UBERON:0004225 biolink:NamedThing respiratory system smooth muscle A portion of smooth muscle tissue that is part of a respiratory system [Automatically generated definition]. RBO_relaxed.owl UBERON:0004226 biolink:NamedThing gastrointestinal system smooth muscle A portion of smooth muscle tissue that is part of a digestive system [Automatically generated definition]. RBO_relaxed.owl UBERON:0004231 biolink:NamedThing anal region smooth muscle A portion of smooth muscle tissue that is part of an anal region [Automatically generated definition]. RBO_relaxed.owl UBERON:0004236 biolink:NamedThing arteriole smooth muscle A portion of smooth muscle tissue that is part of an arteriole [Automatically generated definition]. RBO_relaxed.owl UBERON:0004237 biolink:NamedThing blood vessel smooth muscle Smooth muscle found within, and composing the majority of the wall of blood vessels. RBO_relaxed.owl UBERON:0004238 biolink:NamedThing spleen smooth muscle A portion of smooth muscle tissue that is part of a spleen [Automatically generated definition]. RBO_relaxed.owl UBERON:0004239 biolink:NamedThing small intestine smooth muscle A portion of smooth muscle tissue that is part of a small intestine [Automatically generated definition]. RBO_relaxed.owl UBERON:0004246 biolink:NamedThing outflow tract smooth muscle A portion of smooth muscle tissue that is part of a outflow tract [Automatically generated definition]. RBO_relaxed.owl UBERON:0004297 biolink:NamedThing respiratory system blood vessel smooth muscle A blood vessel smooth muscle that is part of a respiratory system [Automatically generated definition]. RBO_relaxed.owl UBERON:0004695 biolink:NamedThing arterial system smooth muscle A portion of smooth muscle tissue that is part of an arterial system [Automatically generated definition]. RBO_relaxed.owl UBERON:0004696 biolink:NamedThing venous system smooth muscle A portion of smooth muscle tissue that is part of a venous system [Automatically generated definition]. RBO_relaxed.owl UBERON:0012416 biolink:NamedThing respiratory system arterial smooth muscle RBO_relaxed.owl UBERON:0012418 biolink:NamedThing respiratory system venous smooth muscle A smooth muscle tissue that is part of a respiratory system venous blood vessel. RBO_relaxed.owl UBERON:0015783 biolink:NamedThing smooth muscle layer in fatty layer of subcutaneous tissue A smooth muscle tissue that is part of a hypodermis. RBO_relaxed.owl UBERON:0018112 biolink:NamedThing rectum smooth muscle tissue Any portion of smooth muscle tissue that is part of the rectum. RBO_relaxed.owl UBERON:8480002 biolink:NamedThing thoracic aorta smooth muscle tissue A portion of smooth muscle tissue that is part of the thoracic aorta. RBO_relaxed.owl UBERON:0002128 biolink:NamedThing superior olivary complex A collection of brainstem nuclei that functions in multiple aspects of hearing and is an important component of the ascending and descending auditory pathways of the auditory system. RBO_relaxed.owl UBERON:0007245 biolink:NamedThing nuclear complex of neuraxis Gray matter of the central nervous system which is a collection of clustered nuclei. RBO_relaxed.owl UBERON:0007641 biolink:NamedThing trigeminal nuclear complex The sensory trigeminal nerve nuclei are the largest of the cranial nerve nuclei, and extend through the whole of the midbrain, pons and medulla. There is also a distinct trigeminal motor nucleus that is medial to the chief sensory nucleus[WP]. RBO_relaxed.owl UBERON:0019263 biolink:NamedThing gray matter of hindbrain RBO_relaxed.owl UBERON:0003619 biolink:NamedThing aorta tunica intima The innermost layer of the aorta, containing the endothelium and an inner elastic membrane. RBO_relaxed.owl UBERON:0005740 biolink:NamedThing tunica intima of artery A tunica intima that is part of a artery. RBO_relaxed.owl UBERON:0007242 biolink:NamedThing tunica intima of vein A tunica intima that is part of a vein. RBO_relaxed.owl UBERON:0002167 biolink:NamedThing right lung Lung which consists of the right upper lobe, middle lobe and right lower lobe.[FMA]. RBO_relaxed.owl UBERON:0002168 biolink:NamedThing left lung Lung which consists of the left upper lobe and left lower lobe.[FMA]. RBO_relaxed.owl UBERON:0003426 biolink:NamedThing dermis adipose tissue An adipose tissue that is part of a dermis [Automatically generated definition]. RBO_relaxed.owl UBERON:0007808 biolink:NamedThing adipose tissue of abdominal region Adipose tissue that is located in the abdominal region. This includes any subcutaneous fat, visceral fat or encapsulated adipose tissue depots. RBO_relaxed.owl UBERON:0014454 biolink:NamedThing visceral abdominal adipose tissue Subcutaneous adipose tissue that is located in the peritoneal cavity. RBO_relaxed.owl UBERON:0014455 biolink:NamedThing subcutaneous abdominal adipose tissue Subcutaneous adipose tissue that is located in the abdominal region. RBO_relaxed.owl UBERON:0019143 biolink:NamedThing intramuscular adipose tissue Adipose tissue which is located throughout skeletal muscle and is responsible for the marbling seen in certain cuts of beef. In humans, excess accumulation of intramuscular fat is associated with insulin resistance and type 2 diabetes. RBO_relaxed.owl UBERON:0035814 biolink:NamedThing pericardial fat The sum of epicardial and paracardial fat deposits. RBO_relaxed.owl UBERON:0035815 biolink:NamedThing paracardial fat Fat deposits in the mediastinum outside the parietal pericardium . RBO_relaxed.owl UBERON:0035818 biolink:NamedThing visceral fat Any fat deposit surrounding a visceral organ. RBO_relaxed.owl UBERON:0011362 biolink:NamedThing cranial blood vasculature A blood vasculature that is part of a head. RBO_relaxed.owl UBERON:0011134 biolink:NamedThing nonsynovial joint Joint in which the articulating bones or cartilages are connected by ligaments or fibrocartilage without an intervening synovial cavity. Examples: sagittal suture, inferior tibiofibular syndesmosis, costochondral joint, pubic symphysis. RBO_relaxed.owl UBERON:0003694 biolink:NamedThing atlanto-axial joint The Atlanto-axial joint is of a complicated nature, comprising no fewer than four distinct joints. There is a pivot articulation between the odontoid process of the axis and the ring formed by the anterior arch and the transverse ligament of the atlas. RBO_relaxed.owl UBERON:0008114 biolink:NamedThing joint of girdle A skeletal joint that is part of a appendage girdle region. RBO_relaxed.owl UBERON:0008823 biolink:NamedThing neural tube derived brain A brain that develops_from a neural tube. RBO_relaxed.owl UBERON:0015007 biolink:NamedThing cervical vertebra endochondral element A vertebral endochondral element in the cervical region of the vertebral column. RBO_relaxed.owl UBERON:0002241 biolink:NamedThing chondrocranium Endoskeletal elements that encase the brain, nose, inner ear[cjm]. that part of the neurocranium formed by endochondral ossification and comprising the bones of the base of the skull[TFD]. RBO_relaxed.owl UBERON:0003113 biolink:NamedThing dermatocranium Subdivision of skeleton that includes all dermal bones in the cranial skeleton[ZFA,modified]. RBO_relaxed.owl UBERON:0002296 biolink:NamedThing dorsal mesentery The mesentery that originates from the dorsal side of the peritoneal cavity[ZFA]. RBO_relaxed.owl UBERON:0003061 biolink:NamedThing blood island Blood islands are structures in the developing embryo which lead to many different parts of the circulatory system. They primarily derive from plexuses formed from angioblasts. Within them, vacuoles appear through liquefaction of the central part of the syncytium into plasma. The lumen of the blood vessels thus formed is probably intracellular. The flattened cells at the periphery form the endothelium. The nucleated red blood corpuscles develop either from small masses of the original angioblast left attached to the inner wall of the lumen or directly from the flat endothelial cells. In either case the syncytial mass thus formed projects from and is attached to the wall of the vessel. Such a mass is known as a blood island and hemoglobin gradually accumulates within it. Later the cells on the surface round up, giving the mass a mulberry-like appearance. Then the red blood cells break loose and are carried away in the plasma. Such free blood cells continue to divide. Blood islands have been seen in the area vasculosa in the omphalomesenteric vein and arteries, and in the dorsal aorta[WP, unvetted]. RBO_relaxed.owl UBERON:0003869 biolink:NamedThing presumptive ganglion A presumptive structure that has the potential to develop into a ganglion. RBO_relaxed.owl UBERON:0003921 biolink:NamedThing pancreas primordium Embryonic structure that develops into pancreatic bud. RBO_relaxed.owl UBERON:0004348 biolink:NamedThing optic eminence The embryonic structure that gives rise to the corneal ectoderm. RBO_relaxed.owl UBERON:0005425 biolink:NamedThing presumptive neural retina Portion of tissue that is the inner layer of the optic cup and will become the neural retina. RBO_relaxed.owl UBERON:0005729 biolink:NamedThing pectoral appendage field A limb/fin field that has the potential to develop into a pectoral appendage bud mesenchyme. RBO_relaxed.owl UBERON:0005730 biolink:NamedThing pelvic appendage field A limb/fin field that has the potential to develop into a pelvic appendage bud mesenchyme. RBO_relaxed.owl UBERON:0006238 biolink:NamedThing future brain The embryonic precursor of the brain. RBO_relaxed.owl UBERON:0006241 biolink:NamedThing future spinal cord RBO_relaxed.owl UBERON:0006242 biolink:NamedThing gallbladder primordium A sac-like cavity ventral to the liver, lying in the sub-mesodermal space and closed by a thin sheet of ectodermal cells, from which the future gall bladder develops. RBO_relaxed.owl UBERON:0006283 biolink:NamedThing future cardiac ventricle Multi-tissue structure that is part of the heart tube and will become the cardiac ventricle. RBO_relaxed.owl UBERON:0006595 biolink:NamedThing presumptive endoderm Presumptive structure of the blastula that will develop into endoderm. RBO_relaxed.owl UBERON:0006596 biolink:NamedThing presumptive blood RBO_relaxed.owl UBERON:0006601 biolink:NamedThing presumptive ectoderm Presumptive structure of the blastula that will develop into ectoderm. RBO_relaxed.owl UBERON:0006603 biolink:NamedThing presumptive mesoderm Presumptive structure of the blastula that will develop into mesoderm. RBO_relaxed.owl UBERON:0007026 biolink:NamedThing presumptive gut RBO_relaxed.owl UBERON:0007277 biolink:NamedThing presumptive hindbrain The rhombencephalon (or hindbrain) is a developmental categorization of portions of the central nervous system in vertebrates. The rhombencephalon can be subdivided in a variable number of transversal swellings called rhombomeres. In the human embryo eight rhombomeres can be distinguished, from caudal to rostral: Rh7-Rh1 and the isthmus (the most rostral rhombomere). A rare disease of the rhombencephalon, 'rhombencephalosynapsis' is characterized by a missing vermis resulting in a fused cerebellum. Patients generally present with cerebellar ataxia. The caudal rhombencephalon has been generally considered as the initiation site for neural tube closure. RBO_relaxed.owl UBERON:0007278 biolink:NamedThing presumptive sinus venosus Portion of tissue that is part of the heart tube and will become the sinus venosus. RBO_relaxed.owl UBERON:0007280 biolink:NamedThing presumptive endocardium A presumptive structure that has the potential to develop into a endocardium. RBO_relaxed.owl UBERON:0007281 biolink:NamedThing presumptive midbrain hindbrain boundary Embryonic structure that gives rise to the midbrain hindbrain boundary. RBO_relaxed.owl UBERON:0007282 biolink:NamedThing presumptive segmental plate A presumptive structure that has the potential to develop into a presomitic mesoderm. RBO_relaxed.owl UBERON:0007285 biolink:NamedThing presumptive paraxial mesoderm The part of the blastula that has the potential to develop into a paraxial mesoderm. RBO_relaxed.owl UBERON:0009615 biolink:NamedThing midbrain hindbrain boundary neural plate RBO_relaxed.owl UBERON:0009616 biolink:NamedThing presumptive midbrain A presumptive structure that has the potential to develop into a midbrain. RBO_relaxed.owl UBERON:0010084 biolink:NamedThing future diaphragm A structure that will develop into a diaphragm. RBO_relaxed.owl UBERON:0010092 biolink:NamedThing future metencephalon A developing anatomical structure that has the potential to develop into a metencephalon. RBO_relaxed.owl UBERON:0010096 biolink:NamedThing future myelencephalon A developing anatomical structure that has the potential to develop into a myelencephalon. RBO_relaxed.owl UBERON:0010227 biolink:NamedThing future cardiac atrium Multi-tissue structure that is part of the heart tube and will become the cardiac atrium. RBO_relaxed.owl UBERON:0010375 biolink:NamedThing pancreas dorsal primordium RBO_relaxed.owl UBERON:0010376 biolink:NamedThing pancreas ventral primordium RBO_relaxed.owl UBERON:0016880 biolink:NamedThing future nervous system Primordium that develops into the nervous system. RBO_relaxed.owl UBERON:0007414 biolink:NamedThing nucleus of midbrain tegmentum A nucleus of brain that spans a midbrain tegmentum. RBO_relaxed.owl UBERON:0011777 biolink:NamedThing nucleus of spinal cord A neural nucleus that is part of the spinal cord. RBO_relaxed.owl UBERON:0002315 biolink:NamedThing gray matter of spinal cord The ridge-shaped grey matter of the spinal cord that extends longitudunally through the center of each half of the spinal cord, and are largely or entirely composed of nerve cell bodies and their dendrites and some supportive tissue. RBO_relaxed.owl UBERON:0003528 biolink:NamedThing brain gray matter A gray matter that is part of a brain [Automatically generated definition]. RBO_relaxed.owl UBERON:0010125 biolink:NamedThing future superior salivatory nucleus A gray matter that has the potential to develop into a superior salivatory nucleus. RBO_relaxed.owl UBERON:0010285 biolink:NamedThing midbrain basal plate Portion of tissue that is dorsolateral to the floor plate and part of the midbrain. RBO_relaxed.owl UBERON:0019267 biolink:NamedThing gray matter of midbrain RBO_relaxed.owl UBERON:0002343 biolink:NamedThing abdomen musculature Set of all muscles in abdomen. RBO_relaxed.owl UBERON:0004461 biolink:NamedThing skeletal musculature of head Any collection of skeletal muscles that is part of a head [Automatically generated definition]. RBO_relaxed.owl UBERON:0004464 biolink:NamedThing musculature of thorax Any collection of muscles that is part of a thorax [Automatically generated definition]. RBO_relaxed.owl UBERON:0004465 biolink:NamedThing musculature of neck Any collection of muscles that is part of a neck [Automatically generated definition]. RBO_relaxed.owl UBERON:0004468 biolink:NamedThing set of muscles of vertebral column RBO_relaxed.owl UBERON:0004469 biolink:NamedThing musculature of back Any collection of muscles that is part of a back [Automatically generated definition]. RBO_relaxed.owl UBERON:0004470 biolink:NamedThing musculature of pelvic girdle Any collection of muscles that is part of a pelvic girdle [Automatically generated definition]. RBO_relaxed.owl UBERON:0004471 biolink:NamedThing musculature of pectoral girdle A subdivision of the musculature of the body in the pectoral girdle region. Includes pectoral and shoulder muscles. RBO_relaxed.owl UBERON:0004473 biolink:NamedThing musculature of face Any collection of muscles that is part of a face. RBO_relaxed.owl UBERON:0004479 biolink:NamedThing musculature of trunk Any collection of muscles that is part of a trunk [Automatically generated definition]. RBO_relaxed.owl UBERON:0007269 biolink:NamedThing pectoral appendage musculature Any collection of muscles that is part of a pectoral appendage. RBO_relaxed.owl UBERON:0007270 biolink:NamedThing pelvic appendage musculature Any collection of muscles that is part of a pelvic appendage. RBO_relaxed.owl UBERON:0007271 biolink:NamedThing appendage musculature Any collection of muscles that is part of an appendage. RBO_relaxed.owl UBERON:0008229 biolink:NamedThing craniocervical region musculature Musculature system of the pharyngeal and head regions. RBO_relaxed.owl UBERON:0013700 biolink:NamedThing axial musculature Musculature of the head and neck, spine, and ribs. RBO_relaxed.owl UBERON:0014792 biolink:NamedThing musculature of pelvic complex Any collection of muscles that is part of a pelvic complex. The pelvic complex comprises the pelvic girdle and the associated limb or fin. RBO_relaxed.owl UBERON:0014793 biolink:NamedThing musculature of pectoral complex Any collection of muscles that is part of a pectoral complex. The pectoral complex comprises the pectoral girdle and the associated limb or fin. RBO_relaxed.owl UBERON:0013507 biolink:NamedThing thoracic vertebra cartilage element A thoracic vertebra endochondral element that is composed primarily of cartilage tissue. RBO_relaxed.owl UBERON:0013508 biolink:NamedThing thoracic vertebra pre-cartilage condensation A thoracic vertebra endochondral element that is composed primarily of a pre-cartilage condensation. RBO_relaxed.owl UBERON:0006660 biolink:NamedThing muscular coat A region of muscle in many organs in the vertebrate body, adjacent to the submucosa membrane. It is responsible for gut movement such as peristalsis. RBO_relaxed.owl UBERON:0004493 biolink:NamedThing cardiac muscle tissue of myocardium A portion of cardiac muscle tissue that is part of a myocardium [Automatically generated definition]. RBO_relaxed.owl UBERON:0010131 biolink:NamedThing conducting tissue of heart Any portion of cardiac muscle tissue that is part of the conducting system of heart or the Purkinje fibers. RBO_relaxed.owl UBERON:8000009 biolink:NamedThing Purkinje fiber network A collection of Purkinje fibers that receives signals from the right and left bundle branches and innervates the ventricular cardiac muscle. The Purkinje fiber network creates synchronized contractions of the heart ventricles. RBO_relaxed.owl UBERON:0003379 biolink:NamedThing cardiac muscle of right atrium A portion of cardiac muscle tissue that is part of a right atrium [Automatically generated definition]. RBO_relaxed.owl UBERON:0004491 biolink:NamedThing cardiac muscle tissue of interatrial septum A portion of cardiac muscle tissue that is part of a interatrial septum [Automatically generated definition]. RBO_relaxed.owl UBERON:0003452 biolink:NamedThing trabecula carnea cardiac muscle tissue A portion of cardiac muscle tissue that is part of a trabecula carnea [Automatically generated definition]. RBO_relaxed.owl UBERON:0002396 biolink:NamedThing vomer The triangular flat bone of the nasal septum. RBO_relaxed.owl UBERON:0008001 biolink:NamedThing irregular bone The irregular bones are bones which, from their peculiar form, cannot be grouped as long bone, short bone, flat bone or sesamoid bone. Irregular bones serve various purposes in the body, such as protection of nervous tissue, affording multiple anchor points for skeletal muscle attachment (as with the sacrum), and maintaining pharynx and trachea support, and tongue attachment (such as the hyoid bone). They consist of cancellous tissue enclosed within a thin layer of compact bone. The irregular bones are: the vertebrC&, sacrum, coccyx, temporal, sphenoid, ethmoid, zygomatic, maxilla, mandible, palatine, inferior nasal concha, and hyoid. RBO_relaxed.owl UBERON:0011597 biolink:NamedThing bone of upper jaw Any bone that is part of the upper jaw skeleton. This includes (when present): the maxilla, the quadrate (in some species). RBO_relaxed.owl UBERON:0011094 biolink:NamedThing vertebra cartilage element The cartilaginous form of a vertebral element, a skeletal element that forms around the notochord and is part of the vertebral column. RBO_relaxed.owl UBERON:0011095 biolink:NamedThing vertebra pre-cartilage condensation The pre-cartilaginous form of a vertebral element, a skeletal element that forms around the notochord and is part of the vertebral column. RBO_relaxed.owl UBERON:0003458 biolink:NamedThing neck bone A bone that is part of a neck [Automatically generated definition]. RBO_relaxed.owl UBERON:0013505 biolink:NamedThing cervical vertebra cartilage element A cervical vertebra endochondral element that is composed primarily of cartilage tissue. RBO_relaxed.owl UBERON:0013506 biolink:NamedThing cervical vertebra pre-cartilage condensation A cervical vertebra endochondral element that is composed primarily of a pre-cartilage condensation. RBO_relaxed.owl UBERON:0002481 biolink:NamedThing bone tissue Skeletal tissue with a collagen-rich extracellular matrix vascularized, mineralized with hydroxyapatite and typically including osteocytes located in lacunae that communicate with one another by cell processes (in canaliculi). Bone is deposited by osteoblasts. RBO_relaxed.owl UBERON:0003457 biolink:NamedThing head bone A bone that is part of a head [Automatically generated definition]. RBO_relaxed.owl UBERON:0003828 biolink:NamedThing abdominal segment bone A bone that is part of an abdominal segment of trunk [Automatically generated definition]. RBO_relaxed.owl UBERON:0004766 biolink:NamedThing cranial bone A bone that is part of a cranium. RBO_relaxed.owl UBERON:0004768 biolink:NamedThing bone of lower jaw Any bone that is part of the lower jaw skeleton. This includes (when present): the dentary/mandible, the articular, the splenial, the suprangular. RBO_relaxed.owl UBERON:0006068 biolink:NamedThing bone of tail A bone that is part of a post-anal tail. RBO_relaxed.owl UBERON:0007719 biolink:NamedThing bone of reproductive organ A bone that is part of a reproductive organ. RBO_relaxed.owl UBERON:0007828 biolink:NamedThing girdle bone/zone A bone that is part of a appendage girdle region. RBO_relaxed.owl UBERON:0007829 biolink:NamedThing pectoral girdle bone A bone that is part of a pectoral girdle region. RBO_relaxed.owl UBERON:0007842 biolink:NamedThing membrane bone Bone element that arises as a result of intramembranous ossification. RBO_relaxed.owl UBERON:0007914 biolink:NamedThing bone of craniocervical region A bone that is part of a craniocervical region. RBO_relaxed.owl UBERON:0008909 biolink:NamedThing perichordal bone Bone element that is adjacent to the notochord. RBO_relaxed.owl UBERON:0010740 biolink:NamedThing bone of appendage girdle complex A bone that is part of an appendage girdle complex (i.e. any bone in a limb, fin or girdle). RBO_relaxed.owl UBERON:0010741 biolink:NamedThing bone of pectoral complex A bone that is part of a pectoral complex. Examples: scapula, manus phalanx, any carpal bone, any bone of the pectoral fin. RBO_relaxed.owl UBERON:0010742 biolink:NamedThing bone of pelvic complex A bone that is part of a pelvic complex. Examples: pubis, ischium, fot phalanx, any tarsal bone, any bone of the pelvic fin or girdle. RBO_relaxed.owl UBERON:0012075 biolink:NamedThing replacement bone Bone that forms as a replacement of another structural tissue. RBO_relaxed.owl UBERON:0002522 biolink:NamedThing tunica media The middle layer of an artery or vein. [WP,unvetted]. RBO_relaxed.owl UBERON:0002546 biolink:NamedThing cranial placode Ectodermal placode that develops in the head into a part of the sensory nervous system. With a few exceptions (lens, adenohypophyseal), cranial placodes are neurogenic. RBO_relaxed.owl UBERON:0011814 biolink:NamedThing non-neurogenic ectodermal placode Ectodermal placode that does not develop into a component of the nervous system. RBO_relaxed.owl UBERON:0002561 biolink:NamedThing lumen of central nervous system The cavity that is enclosed by the central nervous system. In vertebrates this is the cavity that includes as parts ventricular cavities and the central canal of the spinal cord that develops from the lumen of the neura tube. RBO_relaxed.owl UBERON:0010527 biolink:NamedThing cavity of bone organ An organ cavity that surrounded_by a bone. RBO_relaxed.owl UBERON:0002726 biolink:NamedThing cervical spinal cord A spinal cord segment that adjacent_to a cervical region. RBO_relaxed.owl UBERON:0005844 biolink:NamedThing spinal cord segment RBO_relaxed.owl UBERON:0003038 biolink:NamedThing thoracic spinal cord The thoracic nerves are the spinal nerves emerging from the thoracic vertebrae. [WP,unvetted]. RBO_relaxed.owl UBERON:0005845 biolink:NamedThing caudal segment of spinal cord A spinal cord segment that adjacent_to a caudal region. RBO_relaxed.owl UBERON:0003067 biolink:NamedThing dorsolateral placode Lateral neurogenic placodes positioned dorsal of the epibranchial placodes. RBO_relaxed.owl UBERON:0003078 biolink:NamedThing epibranchial placode Focal thickenings of the embryonic ectoderm that form immediately dorsal and caudal of the clefts between the pharyngeal arches and that produce the neuroblasts that migrate and condense to form the distal cranial ganglia. RBO_relaxed.owl UBERON:0003070 biolink:NamedThing trigeminal placode complex A neurogenic placode that arises at the level of the midbrain-hindbrain boundary and develops into a trigeminal ganglion. RBO_relaxed.owl UBERON:0005856 biolink:NamedThing developing mesenchymal condensation A delimited region of dense mesenchyme within looser mesenchyme. RBO_relaxed.owl UBERON:0009494 biolink:NamedThing pharyngeal arch mesenchymal region A portion of mesenchymal tissue associated with an individual pharyngeal arch. RBO_relaxed.owl UBERON:0003089 biolink:NamedThing sclerotome Ventral somitic compartment that is a precursor of the axial skeleton[XAO]. Sclerotomes eventually differentiate into the vertebrae and most of the skull. The caudal (posterior) half of one sclerotome fuses with the rostral (anterior) half of the adjacent one to form each vertebra. From their initial location within the somite, the sclerotome cells migrate medially towards the notochord. These cells meet the sclerotome cells from the other side to form the vertebral body. From this vertebral body, sclerotome cells move dorsally and surround the developing spinal cord, forming the vertebral arch[WP]. RBO_relaxed.owl UBERON:0005863 biolink:NamedThing cartilaginous condensation Cell condensation that is an aggregation of mesenchymal cells that are committed to differentiate into chondroblasts and chondrocytes. RBO_relaxed.owl UBERON:0005865 biolink:NamedThing pre-muscle condensation RBO_relaxed.owl UBERON:0007530 biolink:NamedThing migrating mesenchyme population Mesenchymal cells that are migrating. RBO_relaxed.owl UBERON:0005563 biolink:NamedThing trigeminal neural crest Cranial neural crest which gives rise to the trigeminal ganglion. RBO_relaxed.owl UBERON:0009920 biolink:NamedThing optic neural crest RBO_relaxed.owl UBERON:0003115 biolink:NamedThing pharyngeal arch 4 Contributes to development of the cartilage of the larynx, laryngeal, pharyngeal, and soft palate muscles, superior parathyroid gland, and C-cells of the thymus. RBO_relaxed.owl UBERON:0003117 biolink:NamedThing pharyngeal arch 6 The 6th pharyngeal arch. contributes to the development of the sternocleidomastoid and trapezius muscles. RBO_relaxed.owl UBERON:0004362 biolink:NamedThing pharyngeal arch 1 The first of the series of pharyngeal arches that develop into jaw bones or their homologs, and their associated nerves and arteries. RBO_relaxed.owl UBERON:0003118 biolink:NamedThing pharyngeal arch artery 1 The vessels formed within the first pair of branchial arches in embryogenesis. RBO_relaxed.owl UBERON:0003121 biolink:NamedThing pharyngeal arch artery 4 The vessels formed within the fourth pair of branchial arches in embryogenesis. RBO_relaxed.owl UBERON:0003123 biolink:NamedThing pharyngeal arch artery 6 The vessels formed within the sixth pair of branchial arches in embryogenesis. RBO_relaxed.owl UBERON:0011919 biolink:NamedThing yolk sac blood island Masses of developing blood cells attached to endothelium in the yolk sac. RBO_relaxed.owl UBERON:0003384 biolink:NamedThing skeletal muscle tissue of pharynx A portion of skeletal muscle tissue that is part of a pharynx [Automatically generated definition]. RBO_relaxed.owl UBERON:0003898 biolink:NamedThing skeletal muscle tissue of trunk A portion of skeletal muscle tissue in the trunk. RBO_relaxed.owl UBERON:0004495 biolink:NamedThing skeletal muscle tissue of diaphragm A portion of skeletal muscle tissue that is part of a diaphragm [Automatically generated definition]. RBO_relaxed.owl UBERON:0004830 biolink:NamedThing respiratory system skeletal muscle A portion of skeletal muscle tissue that is part of a respiratory system [Automatically generated definition]. RBO_relaxed.owl UBERON:0004831 biolink:NamedThing esophagus skeletal muscle A portion of skeletal muscle tissue that is part of a esophagus [Automatically generated definition]. RBO_relaxed.owl UBERON:0004832 biolink:NamedThing anal region skeletal muscle A portion of skeletal muscle tissue that is part of an anal region [Automatically generated definition]. RBO_relaxed.owl UBERON:0004833 biolink:NamedThing lip skeletal muscle A portion of skeletal muscle tissue that is part of a lip [Automatically generated definition]. RBO_relaxed.owl UBERON:0003314 biolink:NamedThing eye mesenchyme Mesenchyme that is part of a developing camera-type eye. RBO_relaxed.owl UBERON:0003315 biolink:NamedThing mesenchyme of ovary Mesenchyme that is part of a developing ovary [Automatically generated definition]. RBO_relaxed.owl UBERON:0003316 biolink:NamedThing mesenchyme of yolk sac The portion of the yolk sac that is derived from mesoderm and consists of mesenchyme. RBO_relaxed.owl UBERON:0003412 biolink:NamedThing pelvic appendage bud mesenchyme Mesenchyme that is part of a pelvic appendage bud. RBO_relaxed.owl UBERON:0003413 biolink:NamedThing pectoral appendage bud mesenchyme Mesenchyme that is part of a pectoral appendage bud. RBO_relaxed.owl UBERON:0005691 biolink:NamedThing 4th arch mesenchyme Mesenchyme that is part of a pharyngeal arch 4. RBO_relaxed.owl UBERON:0006905 biolink:NamedThing mandibular process mesenchyme Mesenchyme that is part of a mandibular prominence. RBO_relaxed.owl UBERON:0009204 biolink:NamedThing medial nasal process mesenchyme Mesenchyme that is part of a medial nasal prominence. RBO_relaxed.owl UBERON:0009482 biolink:NamedThing associated mesenchyme of foregut-midgut junction Mesenchyme that is part of a foregut-midgut junction. RBO_relaxed.owl UBERON:0009501 biolink:NamedThing mesenchyme of fronto-nasal process The embryonic connective tissue made up of loosely aggregated mesenchymal cells, supported by interlaminar jelly, that gives rise to the frontonasal region of the head. RBO_relaxed.owl UBERON:0009503 biolink:NamedThing mesenchyme of hindgut Mesenchyme that is part of a developing hindgut. RBO_relaxed.owl UBERON:0009584 biolink:NamedThing 1st arch mandibular mesenchyme Mesenchyme that is part of a 1st arch mandibular component. RBO_relaxed.owl UBERON:0009602 biolink:NamedThing left lung associated mesenchyme Mesenchyme that is part of a developing left lung. RBO_relaxed.owl UBERON:0009603 biolink:NamedThing right lung associated mesenchyme Mesenchyme that is part of a developing right lung. RBO_relaxed.owl UBERON:0009752 biolink:NamedThing pancreas mesenchyme The embryonic connective tissue made up of loosely aggregated mesenchymal cells, supported by interlaminar jelly, that gives rise to the developing pancreas. RBO_relaxed.owl UBERON:0009891 biolink:NamedThing facial mesenchyme Mesenchyme that is part of a developing face. RBO_relaxed.owl UBERON:0010031 biolink:NamedThing 6th arch mesenchyme Mesenchyme that is part of a pharyngeal arch 6. RBO_relaxed.owl UBERON:0010042 biolink:NamedThing 1st arch mesenchyme Mesenchyme that is part of a pharyngeal arch 1. RBO_relaxed.owl UBERON:0010045 biolink:NamedThing 1st arch maxillary mesenchyme Mesenchyme that is part of a 1st arch maxillary component. RBO_relaxed.owl UBERON:0010252 biolink:NamedThing 1st arch mandibular mesenchyme from neural crest Mesenchyme that develops_from a neural crest and is part of a 1st arch mandibular mesenchyme. RBO_relaxed.owl UBERON:0010253 biolink:NamedThing 1st arch maxillary mesenchyme from neural crest Mesenchyme that develops_from a neural crest and is part of a 1st arch maxillary mesenchyme. RBO_relaxed.owl UBERON:0010256 biolink:NamedThing 4th arch mesenchyme from neural crest Mesenchyme that develops_from a neural crest and is part of a 4th arch mesenchyme. RBO_relaxed.owl UBERON:0010257 biolink:NamedThing 6th arch mesenchyme from neural crest Mesenchyme that develops_from a neural crest and is part of a 6th arch mesenchyme. RBO_relaxed.owl UBERON:0010258 biolink:NamedThing mesenchyme from rhombencephalic neural crest Mesenchyme that develops_from a rhombencephalon neural crest. RBO_relaxed.owl UBERON:0010259 biolink:NamedThing 1st arch mesenchyme from neural crest Mesenchyme that develops_from a neural crest and is part of a 1st arch mesenchyme. RBO_relaxed.owl UBERON:0010329 biolink:NamedThing paired limb/fin bud mesenchyme Mesenchyme that is part of a limb/fin bud. RBO_relaxed.owl UBERON:0010334 biolink:NamedThing maxillary process mesenchyme from neural crest Mesenchyme that develops_from a neural crest and is part of a maxillary process mesenchyme. RBO_relaxed.owl UBERON:0010336 biolink:NamedThing mandibular process mesenchyme from neural crest Mesenchyme that develops_from a neural crest and is part of a mandibular process mesenchyme. RBO_relaxed.owl UBERON:0010337 biolink:NamedThing mandibular process mesenchyme from head mesenchyme Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a mandibular process mesenchyme. RBO_relaxed.owl UBERON:0010338 biolink:NamedThing 1st arch maxillary mesenchyme from head mesenchyme Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a 1st arch maxillary mesenchyme. RBO_relaxed.owl UBERON:0010339 biolink:NamedThing 1st arch mandibular mesenchyme from head mesenchyme Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a 1st arch mandibular mesenchyme. RBO_relaxed.owl UBERON:0010341 biolink:NamedThing 1st arch mesenchyme from head mesenchyme Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a 1st arch mesenchyme. RBO_relaxed.owl UBERON:0010345 biolink:NamedThing 4th arch mesenchyme from head mesenchyme Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a 4th arch mesenchyme. RBO_relaxed.owl UBERON:0010347 biolink:NamedThing 6th arch mesenchyme from head mesenchyme Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a 6th arch mesenchyme. RBO_relaxed.owl UBERON:0034995 biolink:NamedThing jaw mesenchyme Mesenchyme that is part of a developing jaw [Automatically generated definition]. RBO_relaxed.owl UBERON:0003389 biolink:NamedThing mesothelium of diaphragm A mesothelium that is part of a diaphragm [Automatically generated definition]. RBO_relaxed.owl UBERON:0003380 biolink:NamedThing cardiac muscle of left atrium A portion of cardiac muscle tissue that is part of a left atrium [Automatically generated definition]. RBO_relaxed.owl UBERON:0003383 biolink:NamedThing cardiac muscle tissue of interventricular septum A portion of cardiac muscle tissue that is part of an interventricular septum [Automatically generated definition]. RBO_relaxed.owl UBERON:0004492 biolink:NamedThing cardiac muscle tissue of cardiac septum A portion of cardiac muscle tissue that is part of a cardiac septum [Automatically generated definition]. RBO_relaxed.owl UBERON:0003388 biolink:NamedThing mesothelium of pericardial cavity A mesothelium that is part of a pericardium [Automatically generated definition]. RBO_relaxed.owl UBERON:0003390 biolink:NamedThing mesothelium of pleural cavity A mesothelium that is part of a pleural cavity [Automatically generated definition]. RBO_relaxed.owl UBERON:0005669 biolink:NamedThing peritoneal cavity mesothelium A mesothelium that is part of a peritoneal cavity. RBO_relaxed.owl UBERON:0007188 biolink:NamedThing mesothelium of serous pericardium A mesothelium that is part of a serous pericardium. RBO_relaxed.owl UBERON:0003406 biolink:NamedThing cartilage of respiratory system A cartilage element that is part of a respiratory system [Automatically generated definition]. RBO_relaxed.owl UBERON:0003601 biolink:NamedThing neck cartilage A cartilage that is part of a neck [Automatically generated definition]. RBO_relaxed.owl UBERON:0003932 biolink:NamedThing cartilage element of chondrocranium A cartilage element of chondrocranium. Example: neurocranial trabecula. RBO_relaxed.owl UBERON:0003933 biolink:NamedThing cranial cartilage A cartilage element that is part of the cranial skeleton. RBO_relaxed.owl UBERON:0011004 biolink:NamedThing pharyngeal arch cartilage A cartilage element that is part of a splanchnocranium. RBO_relaxed.owl UBERON:2001457 biolink:NamedThing postcranial axial cartilage Cartilage which is part of the axial skeleton. RBO_relaxed.owl UBERON:0003495 biolink:NamedThing respiratory system arteriole An arteriole that is part of a respiratory system [Automatically generated definition]. RBO_relaxed.owl UBERON:0003489 biolink:NamedThing respiratory system capillary endothelium An endothelium of capillary that is part of a respiratory system [Automatically generated definition]. RBO_relaxed.owl UBERON:0004848 biolink:NamedThing respiratory system arterial endothelium An endothelium of artery that is part of a respiratory system [Automatically generated definition]. RBO_relaxed.owl UBERON:0004849 biolink:NamedThing respiratory system venous endothelium An endothelium of vein that is part of a respiratory system [Automatically generated definition]. RBO_relaxed.owl UBERON:0003494 biolink:NamedThing respiratory system venule A venule that is part of a respiratory system [Automatically generated definition]. RBO_relaxed.owl UBERON:8410001 biolink:NamedThing small intestine venule Venule of villus of small intestine. RBO_relaxed.owl UBERON:8410008 biolink:NamedThing venule of anorectum A venule that is located in the anorectum. RBO_relaxed.owl UBERON:8410048 biolink:NamedThing venule of colon A venule located in the colon. RBO_relaxed.owl UBERON:8600024 biolink:NamedThing pulmonary venule A venule that is part of a lung and drains oxygenated blood from pulmonary capillaries. A pulmonary venule merges into a pulmonary vein branch that runs in the pulmonary interlobular septa. RBO_relaxed.owl UBERON:0003526 biolink:NamedThing respiratory system capillary A capillary that is part of a respiratory system [Automatically generated definition]. RBO_relaxed.owl UBERON:0022292 biolink:NamedThing splenic arteriole RBO_relaxed.owl UBERON:8410004 biolink:NamedThing small intestine arteriole Arteriole of villus of small intestine. RBO_relaxed.owl UBERON:8410009 biolink:NamedThing arteriole of anorectum An arteriole that is located in the anorectum. RBO_relaxed.owl UBERON:8410015 biolink:NamedThing arteriole of colon An arteriole located in the colon. RBO_relaxed.owl UBERON:8410056 biolink:NamedThing capillary of anorectum A capillary that is part of the anorectum. RBO_relaxed.owl UBERON:8410057 biolink:NamedThing capillary of colon A capillary that is part of the colon. RBO_relaxed.owl UBERON:8410068 biolink:NamedThing capillary of small intestine A capillary that is part of a small intestine. RBO_relaxed.owl UBERON:8480001 biolink:NamedThing capillary of brain A capillary that is part of the brain. RBO_relaxed.owl UBERON:0003611 biolink:NamedThing respiratory system elastic tissue An elastic tissue that is part of a respiratory system [Automatically generated definition]. RBO_relaxed.owl UBERON:0003605 biolink:NamedThing eye skin gland A skin gland that is part of a camera-type eye [Automatically generated definition]. RBO_relaxed.owl UBERON:0003609 biolink:NamedThing aorta elastic tissue The dense connective tissue which contains predominantly elastic fibers and is found in the tunica media of the aorta wall. RBO_relaxed.owl UBERON:0003613 biolink:NamedThing cardiovascular system elastic tissue An elastic tissue that is part of a circulatory system [Automatically generated definition]. RBO_relaxed.owl UBERON:0003615 biolink:NamedThing lung elastic tissue Elastic tissue that is part of a lung [Automatically generated definition]. RBO_relaxed.owl UBERON:0036186 biolink:NamedThing fibroelastic connective tissue RBO_relaxed.owl UBERON:0003618 biolink:NamedThing aorta tunica media The middle layer of the aorta wall, containing the smooth muscle layer and elastic fibers. RBO_relaxed.owl UBERON:0006563 biolink:NamedThing tunica media of pulmonary trunk Tunica media of artery which is continuous with the myocardium of right ventricle.[FMA]. RBO_relaxed.owl UBERON:0007239 biolink:NamedThing tunica media of artery A tunica media that is part of a artery. RBO_relaxed.owl UBERON:0007243 biolink:NamedThing tunica media of vein A tunica media that is part of a vein. RBO_relaxed.owl UBERON:0003687 biolink:NamedThing foramen magnum In anatomy, in the occipital bone, the foramen magnum is one of the several oval or circular apertures in the base of the skull, through which the medulla oblongata (an extension of the spinal cord) enters and exits the skull vault. Apart from the transmission of the medulla oblongata and its membranes, the foramen magnum transmits the Spinal Accessory nerve, vertebral arteries, the anterior and posterior spinal arteries, the membrana tectoria and alar ligaments. [WP,unvetted]. RBO_relaxed.owl UBERON:0005171 biolink:NamedThing hepatic duct Any portion of the ducts that carry bile from the liver to the common bile duct. This may include both intrahapetic components (parts of left and right hepatic ducts) and extrahapetic components (common hepatic duct, plus hilar portion). RBO_relaxed.owl UBERON:0005604 biolink:NamedThing extrahepatic part of hepatic duct RBO_relaxed.owl UBERON:0005613 biolink:NamedThing left dorsal aorta RBO_relaxed.owl UBERON:0005622 biolink:NamedThing right dorsal aorta RBO_relaxed.owl UBERON:0003849 biolink:NamedThing mesencephalic neural crest A neural crest that has_potential_to_developmentally_contribute_to a midbrain. RBO_relaxed.owl UBERON:0003852 biolink:NamedThing rhombencephalon neural crest A neural crest that has_potential_to_developmentally_contribute_to a hindbrain. RBO_relaxed.owl UBERON:0003853 biolink:NamedThing spinal cord neural crest A neural crest that has_potential_to_developmentally_contribute_to a spinal cord. RBO_relaxed.owl UBERON:0007098 biolink:NamedThing mandibular neural crest Cranial neural crest that migrates into the mandibular arch. RBO_relaxed.owl UBERON:0003854 biolink:NamedThing spinal cord neural plate A neural plate that develops_from a future spinal cord. RBO_relaxed.owl UBERON:0009611 biolink:NamedThing midbrain neural plate A neural plate that develops_from a presumptive midbrain. RBO_relaxed.owl UBERON:0009614 biolink:NamedThing hindbrain neural plate A neural plate that develops_from a presumptive hindbrain. RBO_relaxed.owl UBERON:0003923 biolink:NamedThing dorsal pancreatic bud Pancreatic bud that gives rise to the accessory pancreatic duct. RBO_relaxed.owl UBERON:0003924 biolink:NamedThing ventral pancreatic bud Pancreatic bud that gives rise to the major pancreatic duct. RBO_relaxed.owl UBERON:0004015 biolink:NamedThing embryonic-extraembryonic boundary The connection between the embryo proper and extraembryonic tissues. RBO_relaxed.owl UBERON:0034706 biolink:NamedThing proliferating neuroepithelium An epithelium that is undergoing proliferation to provide large numbers of neuronal cells. RBO_relaxed.owl UBERON:0034707 biolink:NamedThing differentiating neuroepithelium A neuroepithelium some of whose cells are undergoing terminal differentiation to become neuronal cells. RBO_relaxed.owl UBERON:0004066 biolink:NamedThing frontonasal prominence The unpaired embryonic prominence that is formed by the tissues surrounding the forebrain vesicle and develops into the forehead and bridge of the nose/snout. RBO_relaxed.owl UBERON:0009292 biolink:NamedThing embryonic nasal process RBO_relaxed.owl UBERON:0004124 biolink:NamedThing myocardium trabecular layer The layer of the myocardium composed of projections of contractile myocytes. The trabecular layer is bounded internally by the endocardium. In zebrafish, unlike the trabeculations of higher vertebrates, both atrial and ventricular trabeculae have more strut-like character, and are more uniform without apparent regional differences[ZFA]. RBO_relaxed.owl UBERON:0015329 biolink:NamedThing respiratory system basement membrane A basement membrane of epithelium that is part of a respiratory system. RBO_relaxed.owl UBERON:0004525 biolink:NamedThing cardiac muscle tissue of trabecula carnea of right ventricle A portion of trabecula carnea cardiac muscle tissue that is part of a right ventricle [Automatically generated definition]. RBO_relaxed.owl UBERON:0004526 biolink:NamedThing cardiac muscle tissue of trabecula carnea of left ventricle A portion of trabecula carnea cardiac muscle tissue that is part of a left ventricle [Automatically generated definition]. RBO_relaxed.owl UBERON:0004571 biolink:NamedThing systemic arterial system The part of the arterial system which carries oxygenated blood away from the heart to the body, and returns deoxygenated blood back to the heart. RBO_relaxed.owl UBERON:0007240 biolink:NamedThing tunica adventitia of artery A tunica adventitia that is part of a artery. RBO_relaxed.owl UBERON:0007241 biolink:NamedThing tunica adventitia of vein A tunica adventitia that is part of a vein. RBO_relaxed.owl UBERON:0004709 biolink:NamedThing pelvic appendage Paired appendage that consists of the posterior appendicular skeleton and associated soft and hard tissues, but excludes the pelvic girdle and its associated soft and hard tissues. RBO_relaxed.owl UBERON:0004710 biolink:NamedThing pectoral appendage Paired appendage that consists of the anterior appendicular skeleton and associated soft and hard tissues, but excludes the pectoral girdle and its associated soft and hard tissues. RBO_relaxed.owl UBERON:0004729 biolink:NamedThing nematode larval stage Nematode larval development begins with the newly hatched first-stage larva (L1) and ends with the end of the last larval stage (for example the fourth larval stage (L4) in C. elegans). Each stage of nematode larval development is characterized by proliferation of specific cell lineages and an increase in body size without alteration of the basic body plan. Nematode larval stages are separated by molts in which each stage-specific exoskeleton, or cuticle, is shed and replaced anew. RBO_relaxed.owl UBERON:0004764 biolink:NamedThing intramembranous bone tissue Bone tissue that forms directly within mesenchyme, and does not replace other tissues[TAO]. Intramembranous ossification is the formation of bone in which osteoblasts secrete a collagen-proteoglycan matrix that binds calcium salts and becomes calcified[GO]. Intramembranous ossification is the way flat bones and the shell of a turtle are formed[GO]. Unlike endochondral ossification, cartilage is not present during intramembranous ossification[WP]. RBO_relaxed.owl UBERON:0004790 biolink:NamedThing skin mucous gland A mucous gland that is part of the skin. RBO_relaxed.owl UBERON:0008861 biolink:NamedThing pyloric gastric gland The gastric glands in the pyloric region of the stomach; the pyloric glands secrete mucin, which coats the stomach and protects it, and hormones such as gastrin and enkephalin[MP]. RBO_relaxed.owl UBERON:0010499 biolink:NamedThing pseudostratified ciliated columnar epithelium Epithelium composed of a single layer of cells, appearing as layered because the column-shaped cells vary in height so the nuclei are at different levels. The basal portions of all the cells are in contact with the basement membrane. It lines the respiratory system and the male reproductive tract. The cilia in the respiratory tract are motile, while the stereocilia in the male reproductive tract are immobile. RBO_relaxed.owl UBERON:0006931 biolink:NamedThing stomach glandular region mucosa Stomach mucosa that is lined with glandular epithelium and part of a stomach glandular region. RBO_relaxed.owl UBERON:0009196 biolink:NamedThing indifferent external genitalia RBO_relaxed.owl UBERON:0005216 biolink:NamedThing optic eminence surface ectoderm An external ectoderm that is part of a optic eminence [Automatically generated definition]. RBO_relaxed.owl UBERON:0005233 biolink:NamedThing medial-nasal process ectoderm An ectoderm that is part of a medial nasal prominence [Automatically generated definition]. RBO_relaxed.owl UBERON:0005234 biolink:NamedThing optic eminence ectoderm An ectoderm that is part of a optic eminence [Automatically generated definition]. RBO_relaxed.owl UBERON:0005662 biolink:NamedThing 4th arch ectoderm An ectoderm that is part of a pharyngeal arch 4. RBO_relaxed.owl UBERON:0009479 biolink:NamedThing ectoderm of buccopharyngeal membrane An ectoderm that is part of a buccopharyngeal membrane. RBO_relaxed.owl UBERON:0005239 biolink:NamedThing basal plate metencephalon RBO_relaxed.owl UBERON:0005337 biolink:NamedThing outflow tract of ventricle A ventricular outflow tract is a portion of either the left ventricle or right ventricle of the heart through which blood passes in order to enter the great arteries. The right ventricular outflow tract (RVOT) is an infundibular extension of the ventricular cavity which connects to the pulmonary artery. The left ventricular outflow tract (LVOT), which connects to the aorta, is nearly indistinguishable from the rest of the ventricle[WP]. RBO_relaxed.owl UBERON:0005338 biolink:NamedThing outflow tract aortic component An outflow tract that is part of a aorta. RBO_relaxed.owl UBERON:0005339 biolink:NamedThing outflow tract pulmonary component RBO_relaxed.owl UBERON:0005946 biolink:NamedThing outflow tract of atrium An outflow tract that is part of a cardiac atrium. RBO_relaxed.owl UBERON:0005398 biolink:NamedThing female reproductive gland A sex gland that is part of a female reproductive system. RBO_relaxed.owl UBERON:0005419 biolink:NamedThing pectoral appendage bud A limb bud that develops into a forelimb or pectoral fin. RBO_relaxed.owl UBERON:0005420 biolink:NamedThing pelvic appendage bud A limb bud that develops into a hindlimb or pelvic fin. RBO_relaxed.owl UBERON:0005478 biolink:NamedThing sulcus limitans of neural tube A longitudinal groove in the neural tube wall that divides the neural tube into dorsal (alar) and ventral (basal) halves (dorsal receives input from sensory neurons, ventral effects motor functions); stretches from the mesencephalon caudad[TMD]. RBO_relaxed.owl UBERON:0005501 biolink:NamedThing rhombomere lateral wall A neural tube lateral wall that is part of a rhombomere. RBO_relaxed.owl UBERON:0005598 biolink:NamedThing trunk somite A somite that is part of a trunk. RBO_relaxed.owl UBERON:0009621 biolink:NamedThing tail somite A somite that is part of a tail. RBO_relaxed.owl UBERON:0005602 biolink:NamedThing dorsal mesogastrium The portion of mesentery attached to the greater curvature of the stomach is named the dorsal mesentery (or dorsal mesogastrium, when referring to the portion at the stomach), and the part which suspends the colon is termed the mesocolon. The dorsal mesogastrium develops into the greater omentum. RBO_relaxed.owl UBERON:0006924 biolink:NamedThing stomach glandular epithelium A glandular epithelium that lines the stomach. The stomach's glandular epithelium is characterized by the presence of gastric glands. RBO_relaxed.owl UBERON:0005666 biolink:NamedThing 4th arch endoderm An endoderm that is part of a pharyngeal arch 4. RBO_relaxed.owl UBERON:0009480 biolink:NamedThing endoderm of buccopharyngeal membrane An endoderm that is part of a buccopharyngeal membrane. RBO_relaxed.owl UBERON:0009550 biolink:NamedThing endoderm of foregut-midgut junction An endoderm that is part of a foregut-midgut junction. RBO_relaxed.owl UBERON:0005685 biolink:NamedThing midgut dorsal mesentery A dorsal mesentery that is part of a midgut. RBO_relaxed.owl UBERON:0012504 biolink:NamedThing adventitia of esophagus An adventitia that is part of a esophagus. RBO_relaxed.owl UBERON:0005953 biolink:NamedThing outflow part of right ventricle Anteriosuperior, smooth-walled portion of the cavity of the right ventricle, beginning at the supraventricular crest and terminating in the pulmonary trunk. RBO_relaxed.owl UBERON:0005956 biolink:NamedThing outflow part of left ventricle Anterosuperior fibrous portion of the left ventricle that connects to the ascending aorta. RBO_relaxed.owl UBERON:0005965 biolink:NamedThing outflow part of right atrium Outflow part of atrium which consists of wall and cavity of the outflow part of right atrium and the tricuspid valve.[FMA]. RBO_relaxed.owl UBERON:0005966 biolink:NamedThing outflow part of left atrium An outflow tract of atrium that is part of a left atrium. RBO_relaxed.owl UBERON:0006056 biolink:NamedThing posterior surface of head RBO_relaxed.owl UBERON:0006677 biolink:NamedThing surface of epithelium An anatomical boundary that adjacent_to a epithelium. RBO_relaxed.owl UBERON:0008115 biolink:NamedThing surface of cartilage An anatomical surface that is part of a cartilage element. RBO_relaxed.owl UBERON:0022288 biolink:NamedThing surface of eyeball RBO_relaxed.owl UBERON:0006072 biolink:NamedThing cervical region of vertebral column That portion of the spine comprising the cervical vertebrae. The neck area of the spine. RBO_relaxed.owl UBERON:0006073 biolink:NamedThing thoracic region of vertebral column That part of the spine comprising the thoracic vertebrae. RBO_relaxed.owl UBERON:0006076 biolink:NamedThing caudal region of vertebral column Subdivision of vertebral column that corresponds to the caudal subdivision of the body, containing the caudal vertebrae. RBO_relaxed.owl UBERON:0009568 biolink:NamedThing trunk region of vertebral column Subdivision of vertebral column that corresponds to the trunk of the body, containing the trunk/presacral vertebrae. In organisms that have a thoracic and lumbar distinction, this corresponds to the sum of both of these regions. RBO_relaxed.owl UBERON:0006304 biolink:NamedThing future trigeminal ganglion RBO_relaxed.owl UBERON:0006518 biolink:NamedThing right lung lobe A lobe of lung that is part of a right lung. RBO_relaxed.owl UBERON:0008951 biolink:NamedThing left lung lobe A lobe of lung that is part of a left lung. RBO_relaxed.owl UBERON:0006566 biolink:NamedThing left ventricle myocardium A myocardium that is part of a left ventricle of a heart. RBO_relaxed.owl UBERON:0006567 biolink:NamedThing right ventricle myocardium A myocardium that is part of a right ventricle of a heart. RBO_relaxed.owl UBERON:0006570 biolink:NamedThing trabecula carnea of right ventricle A trabecula carnea that is part of a heart right ventricle. RBO_relaxed.owl UBERON:0006571 biolink:NamedThing trabecula carnea of left ventricle A trabecula carnea that is part of a heart left ventricle. RBO_relaxed.owl UBERON:0006828 biolink:NamedThing trabecula carnea of atrium The supporting bundles of muscular fibers lining the walls of the atria[MP]. RBO_relaxed.owl UBERON:0011825 biolink:NamedThing loose connective tissue Irregular connective tissue, the intercellular matrix of which contains a sparse irregular network of collagen and elastic fiber bundles. Examples: areolar tissue, neuroglial tissue, mucoid tissue. RBO_relaxed.owl UBERON:0009617 biolink:NamedThing head paraxial mesoderm Bilateral mesenchymal mesoderm parallel and immediately adjacent to the neural tube/notochord; it generates a subset of extra-ocular, and other head, muscles. RBO_relaxed.owl UBERON:0006984 biolink:NamedThing anatomical surface A two dimensional anatomical structure that is the boundary between an anatomical structure and an anatomical substance, an anatomical space or the organism's environment. Examples include the surface of your skin, the surface of the lining of your gut; the surface of the endothelium of you aorta that is in contact with blood.n. RBO_relaxed.owl UBERON:0007389 biolink:NamedThing paired limb/fin cartilage A cartilage tissue that is part of a paired limb or fin. RBO_relaxed.owl UBERON:0008342 biolink:NamedThing intestinal villus of duodenum An intestinal villus in the duodenum. RBO_relaxed.owl UBERON:0008816 biolink:NamedThing embryonic head A head that is part of a embryo. RBO_relaxed.owl UBERON:6000004 biolink:NamedThing panarthropod head RBO_relaxed.owl UBERON:6001730 biolink:NamedThing insect larval head Any head that is part of some larva. RBO_relaxed.owl UBERON:0011198 biolink:NamedThing muscle layer of large intestine A muscle layer that is part of a large intestine. RBO_relaxed.owl UBERON:0011201 biolink:NamedThing muscle layer of small intestine A muscle layer that is part of a small intestine. RBO_relaxed.owl UBERON:0011878 biolink:NamedThing muscle layer of esophagus A muscle layer that is part of a wall of esophagus. RBO_relaxed.owl UBERON:0012367 biolink:NamedThing muscle layer of intestine A muscle layer that is part of an intestine. RBO_relaxed.owl UBERON:0012486 biolink:NamedThing muscle layer of cloaca A muscular coat that is part of a cloaca. RBO_relaxed.owl UBERON:0012488 biolink:NamedThing muscle layer of duodenum A muscular coat that is part of a duodenum. RBO_relaxed.owl UBERON:0012489 biolink:NamedThing muscle layer of colon A muscular coat that is part of a colon. RBO_relaxed.owl UBERON:0018111 biolink:NamedThing muscle layer of rectum A muscle layer that is part of the rectum. RBO_relaxed.owl UBERON:0018261 biolink:NamedThing muscular coat of digestive tract A muscular coat that is part of a digestive tract. RBO_relaxed.owl UBERON:0035805 biolink:NamedThing muscle layer of sigmoid colon A muscle layer that is part of the sigmoid colon. RBO_relaxed.owl UBERON:0009030 biolink:NamedThing left pulmonary vein Vein that drains left lung and returns blood to the heart. RBO_relaxed.owl UBERON:0009032 biolink:NamedThing right pulmonary vein Vein that drains right lung and returns blood to the heart. RBO_relaxed.owl UBERON:0009548 biolink:NamedThing hepatic sinusoid of left of lobe of liver A hepatic sinusoid that is part of a left lobe of liver. RBO_relaxed.owl UBERON:0009549 biolink:NamedThing hepatic sinusoid of right of lobe of liver A hepatic sinusoid that is part of a right lobe of liver. RBO_relaxed.owl UBERON:0009570 biolink:NamedThing spinal cord sulcus limitans A sulcus limitans of neural tube that is part of a future spinal cord. RBO_relaxed.owl UBERON:0009577 biolink:NamedThing metencephalon sulcus limitans A sulcus limitans of neural tube that is part of a future metencephalon. RBO_relaxed.owl UBERON:0009578 biolink:NamedThing myelencephalon sulcus limitans A sulcus limitans of neural tube that is part of a future myelencephalon. RBO_relaxed.owl UBERON:0009581 biolink:NamedThing midbrain mantle layer RBO_relaxed.owl UBERON:0009583 biolink:NamedThing spinal cord mantle layer RBO_relaxed.owl UBERON:0009712 biolink:NamedThing endocardium of right ventricle Any endocardium that is part of the right ventricle of the heart. RBO_relaxed.owl UBERON:0009713 biolink:NamedThing endocardium of left ventricle Any endocardium that is part of the left ventricle of the heart. RBO_relaxed.owl UBERON:0010152 biolink:NamedThing skin mucus A mucous secretion that is produced by glands in the epidermis. RBO_relaxed.owl UBERON:0016552 biolink:NamedThing phlegm Mucus produced in the respiratory tract. RBO_relaxed.owl UBERON:0016553 biolink:NamedThing respiratory system mucus Any mucus produced by a mucosae of the respiratory system. This includes the mucus produced in the nasal cavity (nasal mucus) and mucus produced in the respiratory tract (phlegm). RBO_relaxed.owl UBERON:0010194 biolink:NamedThing hepatic portal system A portal system that begins in capillaries in the wall of the digestive tract and and runs as the hepatic portal vein to the liver. RBO_relaxed.owl UBERON:0010304 biolink:NamedThing non-keratinized stratified squamous epithelium Stratified squamous epithelium is a stratified squamous epithelium, the cells of which synthesizes but does not accumulate keratin. Examples: epithelium of vagina, epithelium of wall of esophagus. RBO_relaxed.owl UBERON:0010528 biolink:NamedThing pneumatic cavity of bone RBO_relaxed.owl UBERON:0010708 biolink:NamedThing pectoral complex Appendage girdle complex that when present, encompasses the pectoral appendicular skeleton and the pectoral girdle. RBO_relaxed.owl UBERON:0011090 biolink:NamedThing skeleton of right pelvic girdle A skeleton of pelvic girdle that is part of a right pelvic girdle region. RBO_relaxed.owl UBERON:0011091 biolink:NamedThing skeleton of left pelvic girdle A skeleton of pelvic girdle that is part of a left pelvic girdle region. RBO_relaxed.owl UBERON:0011092 biolink:NamedThing right pelvic girdle region A pelvic girdle region that is in the right side of a multicellular organism. RBO_relaxed.owl UBERON:0011093 biolink:NamedThing left pelvic girdle region A pelvic girdle region that is in the left side of a multicellular organism. RBO_relaxed.owl UBERON:0011233 biolink:NamedThing synovial membrane of synovial tendon sheath Synovial sac which surrounds parts of one or more tendons. Examples: synovial tendon sheath of manual digit 2, radial bursa. RBO_relaxed.owl UBERON:0011648 biolink:NamedThing jaw muscle RBO_relaxed.owl UBERON:0011695 biolink:NamedThing embryonic cardiovascular system A cardiovascular system that is part of a conceptus. RBO_relaxed.owl UBERON:0011863 biolink:NamedThing bone collagen fibril The connective tissue bundles in the extracellular matrix of bone tissue that are composed of collagen, and play a role in tissue strength and elasticity. RBO_relaxed.owl UBERON:0011864 biolink:NamedThing tendon collagen fibril The connective tissue bundles in the extracellular matrix of tendon tissue that are composed of collagen, and play a role in tissue strength and elasticity. RBO_relaxed.owl UBERON:0011955 biolink:NamedThing left hepatic vein A hepatic vein that is part of a left lobe of liver. RBO_relaxed.owl UBERON:0011956 biolink:NamedThing right hepatic vein A hepatic vein that is part of a right lobe of liver. RBO_relaxed.owl UBERON:0012425 biolink:NamedThing striated border microvillus layer A microvillus layer that is striated and found in the intestine. RBO_relaxed.owl UBERON:0012485 biolink:NamedThing cloacal villus RBO_relaxed.owl UBERON:0034769 biolink:NamedThing lymphomyeloid tissue RBO_relaxed.owl UBERON:0012477 biolink:NamedThing dorsal part of neck The posterior region of the neck, including the suboccipital region. RBO_relaxed.owl UBERON:0013755 biolink:NamedThing arterial blood A blood that is part of a artery. RBO_relaxed.owl UBERON:0013756 biolink:NamedThing venous blood A blood that is part of a vein. RBO_relaxed.owl UBERON:0013757 biolink:NamedThing capillary blood A blood that is part of a capillary. RBO_relaxed.owl UBERON:0014400 biolink:NamedThing hepatic sinusoidal space A sinusoidal space that is part of a hepatic sinusoid. RBO_relaxed.owl UBERON:0014404 biolink:NamedThing female anatomical structure A part of the body present only in females. RBO_relaxed.owl UBERON:0014610 biolink:NamedThing thoracic spinal cord ventral horn A ventral horn of spinal cord that is part of a thoracic spinal cord. RBO_relaxed.owl UBERON:0014621 biolink:NamedThing cervical spinal cord ventral horn A ventral horn of spinal cord that is part of a cervical spinal cord. RBO_relaxed.owl UBERON:0014613 biolink:NamedThing cervical spinal cord gray matter A gray matter of spinal cord that is part of a cervical spinal cord. RBO_relaxed.owl UBERON:0014636 biolink:NamedThing thoracic spinal cord gray matter A gray matter of spinal cord that is part of a thoracic spinal cord. RBO_relaxed.owl UBERON:0015128 biolink:NamedThing subepicardial layer of epicardium RBO_relaxed.owl UBERON:0015480 biolink:NamedThing proper hepatic artery The hepatic artery proper (also proper hepatic artery), arises from the common hepatic artery and runs alongside the portal vein and the common bile duct to form the portal triad. The hepatic artery proper gives off a small supraduodenal artery to the duodenal bulb. Then the right gastric artery comes off and runs to the left along the lesser curvature of the stomach to meet the left gastric artery, which is a branch of the celiac trunk. It subsequently gives off the cystic artery, which feeds the gallbladder, before bifurcating into the right and left hepatic arteries. Of note, the right and left hepatic arteries may demonstrate variant anatomy. A replaced right hepatic artery may arise from the superior mesenteric artery (SMA) and a replaced left hepatic artery may arise from the left gastric artery. RBO_relaxed.owl UBERON:0018135 biolink:NamedThing fibrocollagenous connective tissue RBO_relaxed.owl UBERON:0018692 biolink:NamedThing dorsal side of post-anal tail RBO_relaxed.owl UBERON:0034710 biolink:NamedThing spinal cord ventricular layer RBO_relaxed.owl UBERON:0034874 biolink:NamedThing air in respiratory system Any portion of gas located in a part of the respiratory system that is composed primarily of air. RBO_relaxed.owl UBERON:0034947 biolink:NamedThing gas in respiratory system Any portion of gas located in a part of the respiratory system. RBO_relaxed.owl UBERON:0034946 biolink:NamedThing gas excreted from digestive tract Any excreted gas that is produced by the digestive tract. RBO_relaxed.owl UBERON:0035091 biolink:NamedThing extrinsic post-anal tail muscle A post-anal tail that attaches outside the tail. RBO_relaxed.owl UBERON:0035159 biolink:NamedThing entire surface of organism Anatomical surface, which is the external surface of the whole body. Examples: There is only one body surface. RBO_relaxed.owl UBERON:4200230 biolink:NamedThing surface of bone An anatomical surface that is part of a bone. RBO_relaxed.owl UBERON:0036242 biolink:NamedThing post-embryonic notochord A notochord that has persisted beyond the embryonic stage. RBO_relaxed.owl UBERON:0036285 biolink:NamedThing wall of left ventricle Wall of ventricle which is continuous with the wall of aorta. RBO_relaxed.owl UBERON:0036286 biolink:NamedThing wall of right ventricle Wall of ventricle which is continuous with the wall of pulmonary trunk. RBO_relaxed.owl UBERON:0036288 biolink:NamedThing anterior wall of left ventricle RBO_relaxed.owl UBERON:0036289 biolink:NamedThing anterior wall of right ventricle Region of wall of right ventricle which is continuous with the lateral and septal walls of right ventricle. RBO_relaxed.owl UBERON:0039856 biolink:NamedThing right ovarian vein Ovarian vein, each instance of which is a tributary of some inferior vena cava that drains the right pampiniform plexus of some broad ligament. RBO_relaxed.owl UBERON:0039857 biolink:NamedThing left ovarian vein Ovarian vein, each instance of which is a tributary of some left renal vein that drains the left pampiniform plexus of some broad ligament. RBO_relaxed.owl UBERON:2007013 biolink:NamedThing preplacodal ectoderm Non neural ectoderm that surrounds the presumptive neural plate and gives rise to neurogenic placodes. RBO_relaxed.owl OBO:UO_0000001 biolink:NamedThing length unit A unit which is a standard measure of the distance between two points. RBO_relaxed.owl OBO:UO_0000002 biolink:NamedThing mass unit A unit which is a standard measure of the amount of matter/energy of a physical object. RBO_relaxed.owl OBO:UO_0000003 biolink:NamedThing time unit A unit which is a standard measure of the dimension in which events occur in sequence. RBO_relaxed.owl OBO:UO_0000005 biolink:NamedThing temperature unit RBO_relaxed.owl OBO:UO_0000006 biolink:NamedThing substance unit RBO_relaxed.owl OBO:UO_0000051 biolink:NamedThing concentration unit RBO_relaxed.owl OBO:UO_0000095 biolink:NamedThing volume unit RBO_relaxed.owl OBO:UO_0000105 biolink:NamedThing frequency unit RBO_relaxed.owl OBO:UO_0000127 biolink:NamedThing radiation unit RBO_relaxed.owl OBO:UO_0000270 biolink:NamedThing volumetric flow rate unit RBO_relaxed.owl OBO:UO_0000280 biolink:NamedThing rate unit RBO_relaxed.owl OBO:UO_0000004 biolink:NamedThing electric current unit RBO_relaxed.owl OBO:UO_0000045 biolink:NamedThing base unit RBO_relaxed.owl OBO:UO_0000046 biolink:NamedThing derived unit A derived unit is a unit which is derived from base units.|A unit which is derived from base units. RBO_relaxed.owl OBO:UO_0000047 biolink:NamedThing area unit RBO_relaxed.owl OBO:UO_0000048 biolink:NamedThing acceleration unit RBO_relaxed.owl OBO:UO_0000049 biolink:NamedThing angular velocity unit RBO_relaxed.owl OBO:UO_0000050 biolink:NamedThing angular acceleration unit RBO_relaxed.owl OBO:UO_0000057 biolink:NamedThing momentum unit RBO_relaxed.owl OBO:UO_0000060 biolink:NamedThing speed/velocity unit RBO_relaxed.owl OBO:UO_0000107 biolink:NamedThing force unit RBO_relaxed.owl OBO:UO_0000109 biolink:NamedThing pressure unit RBO_relaxed.owl OBO:UO_0000111 biolink:NamedThing energy unit RBO_relaxed.owl OBO:UO_0000113 biolink:NamedThing power unit RBO_relaxed.owl OBO:UO_0000119 biolink:NamedThing catalytic activity unit RBO_relaxed.owl OBO:UO_0000121 biolink:NamedThing angle unit RBO_relaxed.owl OBO:UO_0000157 biolink:NamedThing light unit RBO_relaxed.owl OBO:UO_0000182 biolink:NamedThing density unit RBO_relaxed.owl OBO:UO_0000186 biolink:NamedThing dimensionless unit RBO_relaxed.owl OBO:UO_0000217 biolink:NamedThing electric potential difference unit RBO_relaxed.owl OBO:UO_0000225 biolink:NamedThing magnetic flux unit RBO_relaxed.owl OBO:UO_0000227 biolink:NamedThing magnetic flux density unit RBO_relaxed.owl OBO:UO_0000231 biolink:NamedThing information unit RBO_relaxed.owl OBO:UO_0000253 biolink:NamedThing surface tension unit RBO_relaxed.owl OBO:UO_0000256 biolink:NamedThing viscosity unit RBO_relaxed.owl OBO:UO_0000261 biolink:NamedThing conduction unit RBO_relaxed.owl OBO:UO_0000267 biolink:NamedThing electric field strength unit RBO_relaxed.owl OBO:UO_0000007 biolink:NamedThing luminous intensity unit RBO_relaxed.owl OBO:UO_0000053 biolink:NamedThing luminance unit RBO_relaxed.owl OBO:UO_0000115 biolink:NamedThing illuminance unit RBO_relaxed.owl OBO:UO_0000117 biolink:NamedThing luminous flux unit RBO_relaxed.owl OBO:UO_0000154 biolink:NamedThing irradiance unit RBO_relaxed.owl OBO:UO_0000159 biolink:NamedThing radiant intensity unit RBO_relaxed.owl OBO:UO_0000161 biolink:NamedThing radiance unit RBO_relaxed.owl OBO:UO_1000312 biolink:NamedThing relative light unit based unit RBO_relaxed.owl OBO:UO_0000008 biolink:NamedThing meter A length unit which is equal to the length of the path traveled by light in vacuum during a time interval of 1/299 792 458 of a second. RBO_relaxed.owl OBO:UO_0000009 biolink:NamedThing kilogram A mass unit which is equal to the mass of the International Prototype Kilogram kept by the BIPM at Svres, France. RBO_relaxed.owl OBO:UO_0000010 biolink:NamedThing second A time unit which is equal to the duration of 9 192 631 770 periods of the radiation corresponding to the transition between the two hyperfine levels of the ground state of the caesium 133 atom. RBO_relaxed.owl OBO:UO_0000011 biolink:NamedThing ampere RBO_relaxed.owl OBO:UO_0000012 biolink:NamedThing kelvin RBO_relaxed.owl OBO:UO_0000013 biolink:NamedThing mole RBO_relaxed.owl OBO:UO_0000014 biolink:NamedThing candela RBO_relaxed.owl OBO:UO_0010011 biolink:NamedThing inch RBO_relaxed.owl OBO:UO_0010012 biolink:NamedThing thou RBO_relaxed.owl OBO:UO_0010013 biolink:NamedThing foot RBO_relaxed.owl OBO:UO_0010014 biolink:NamedThing yard RBO_relaxed.owl OBO:UO_0010015 biolink:NamedThing chain RBO_relaxed.owl OBO:UO_0010016 biolink:NamedThing furlong RBO_relaxed.owl OBO:UO_0010017 biolink:NamedThing mile RBO_relaxed.owl OBO:UO_0010018 biolink:NamedThing league RBO_relaxed.owl OBO:UO_1000008 biolink:NamedThing meter based unit RBO_relaxed.owl OBO:UO_0000015 biolink:NamedThing centimeter A length unit which is equal to one hundredth of a meter or 10^[-2] m. RBO_relaxed.owl OBO:UO_0000016 biolink:NamedThing millimeter A length unit which is equal to one thousandth of a meter or 10^[-3] m. RBO_relaxed.owl OBO:UO_0000017 biolink:NamedThing micrometer A length unit which is equal to one millionth of a meter or 10^[-6] m. RBO_relaxed.owl OBO:UO_0000018 biolink:NamedThing nanometer A length unit which is equal to one thousandth of one millionth of a meter or 10^[-9] m. RBO_relaxed.owl OBO:UO_0000020 biolink:NamedThing picometer RBO_relaxed.owl OBO:UO_0010066 biolink:NamedThing kilometer RBO_relaxed.owl OBO:UO_1000021 biolink:NamedThing gram based unit RBO_relaxed.owl OBO:UO_0000021 biolink:NamedThing gram A mass unit which is equal to one thousandth of a kilogram or 10^[-3] kg. RBO_relaxed.owl OBO:UO_0000022 biolink:NamedThing milligram A mass unit which is equal to one thousandth of a gram or 10^[-3] g. RBO_relaxed.owl OBO:UO_0000023 biolink:NamedThing microgram A mass unit which is equal to one millionth of a gram or 10^[-6] g. RBO_relaxed.owl OBO:UO_0000024 biolink:NamedThing nanogram A mass unit which is equal to one thousandth of one millionth of a gram or 10^[-9] g. RBO_relaxed.owl OBO:UO_0000025 biolink:NamedThing picogram A mass unit which is equal to 10^[-12] g. RBO_relaxed.owl OBO:UO_0000026 biolink:NamedThing femtogram RBO_relaxed.owl OBO:UO_1000010 biolink:NamedThing second based unit RBO_relaxed.owl OBO:UO_0000028 biolink:NamedThing millisecond RBO_relaxed.owl OBO:UO_0000029 biolink:NamedThing microsecond RBO_relaxed.owl OBO:UO_0000030 biolink:NamedThing picosecond RBO_relaxed.owl OBO:UO_0000150 biolink:NamedThing nanosecond RBO_relaxed.owl OBO:UO_1000011 biolink:NamedThing ampere based unit RBO_relaxed.owl OBO:UO_0000037 biolink:NamedThing milliampere RBO_relaxed.owl OBO:UO_0000038 biolink:NamedThing microampere RBO_relaxed.owl OBO:UO_0010054 biolink:NamedThing picoampere RBO_relaxed.owl OBO:UO_1000012 biolink:NamedThing kelvin based unit RBO_relaxed.owl OBO:UO_1000013 biolink:NamedThing mole based unit RBO_relaxed.owl OBO:UO_0000039 biolink:NamedThing micromole A substance unit equal to a millionth of a mol or 10^[-6] mol. RBO_relaxed.owl OBO:UO_0000040 biolink:NamedThing millimole RBO_relaxed.owl OBO:UO_0000041 biolink:NamedThing nanomole A substance unit equal to one thousandth of one millionth of a mole or 10^[-9] mol. RBO_relaxed.owl OBO:UO_0000042 biolink:NamedThing picomole A substance unit equal to 10^[-12] mol. RBO_relaxed.owl OBO:UO_0000043 biolink:NamedThing femtomole RBO_relaxed.owl OBO:UO_0000044 biolink:NamedThing attomole RBO_relaxed.owl OBO:UO_0010048 biolink:NamedThing micromole RBO_relaxed.owl OBO:UO_1000014 biolink:NamedThing candela based unit RBO_relaxed.owl OBO:UO_0000019 biolink:NamedThing angstrom A length unit which is equal to 10 [-10] m. RBO_relaxed.owl OBO:UO_1000019 biolink:NamedThing angstrom based unit RBO_relaxed.owl OBO:UO_0000027 biolink:NamedThing degree Celsius A temperature unit which is equal to one kelvin degree. However, they have their zeros at different points. The centigrade scale has its zero at 273.15 K. RBO_relaxed.owl OBO:UO_1000027 biolink:NamedThing degree Celsius based unit RBO_relaxed.owl OBO:UO_0000031 biolink:NamedThing minute A time unit which is equal to 60 seconds. RBO_relaxed.owl OBO:UO_1000031 biolink:NamedThing minute based unit RBO_relaxed.owl OBO:UO_0000032 biolink:NamedThing hour A time unit which is equal to 3600 seconds or 60 minutes. RBO_relaxed.owl OBO:UO_1000032 biolink:NamedThing hour based unit RBO_relaxed.owl OBO:UO_0000033 biolink:NamedThing day A time unit which is equal to 24 hours. RBO_relaxed.owl OBO:UO_1000033 biolink:NamedThing day based unit RBO_relaxed.owl OBO:UO_0000034 biolink:NamedThing week A time unit which is equal to 7 days. RBO_relaxed.owl OBO:UO_1000034 biolink:NamedThing week based unit RBO_relaxed.owl OBO:UO_0000035 biolink:NamedThing month A time unit which is approximately equal to the length of time of one of cycle of the moon's phases which in science is taken to be equal to 30 days. RBO_relaxed.owl OBO:UO_1000035 biolink:NamedThing month based unit RBO_relaxed.owl OBO:UO_0000036 biolink:NamedThing year A time unit which is equal to 12 months which is science is taken to be equal to 365.25 days. RBO_relaxed.owl OBO:UO_1000036 biolink:NamedThing year based unit RBO_relaxed.owl OBO:UO_0000052 biolink:NamedThing mass density unit RBO_relaxed.owl OBO:UO_0000054 biolink:NamedThing area density unit RBO_relaxed.owl OBO:UO_0000183 biolink:NamedThing linear density unit RBO_relaxed.owl OBO:UO_0000055 biolink:NamedThing molar mass unit RBO_relaxed.owl OBO:UO_0010009 biolink:NamedThing milli RBO_relaxed.owl OBO:UO_1000221 biolink:NamedThing dalton based unit RBO_relaxed.owl OBO:UO_1010031 biolink:NamedThing grain based unit RBO_relaxed.owl OBO:UO_1010032 biolink:NamedThing drachm based unit RBO_relaxed.owl OBO:UO_1010033 biolink:NamedThing ounce based unit RBO_relaxed.owl OBO:UO_1010034 biolink:NamedThing pound based unit RBO_relaxed.owl OBO:UO_1010035 biolink:NamedThing stone based unit RBO_relaxed.owl OBO:UO_1010036 biolink:NamedThing quarter based unit RBO_relaxed.owl OBO:UO_1010037 biolink:NamedThing hundredweight based unit RBO_relaxed.owl OBO:UO_1010038 biolink:NamedThing ton based unit RBO_relaxed.owl OBO:UO_0000056 biolink:NamedThing molar volume unit RBO_relaxed.owl OBO:UO_0000059 biolink:NamedThing specific volume unit RBO_relaxed.owl OBO:UO_1000096 biolink:NamedThing cubic meter based unit RBO_relaxed.owl OBO:UO_1000097 biolink:NamedThing cubic centimeter based unit RBO_relaxed.owl OBO:UO_1000099 biolink:NamedThing liter based unit RBO_relaxed.owl OBO:UO_1000100 biolink:NamedThing cubic decimeter based unit RBO_relaxed.owl OBO:UO_1010026 biolink:NamedThing fluid ounce based unit RBO_relaxed.owl OBO:UO_1010027 biolink:NamedThing gill based unit RBO_relaxed.owl OBO:UO_1010028 biolink:NamedThing pint based unit RBO_relaxed.owl OBO:UO_1010029 biolink:NamedThing quart based unit RBO_relaxed.owl OBO:UO_1010030 biolink:NamedThing gallon based unit RBO_relaxed.owl OBO:UO_1010040 biolink:NamedThing teaspoon based unit RBO_relaxed.owl OBO:UO_0000058 biolink:NamedThing rotational frequency unit RBO_relaxed.owl OBO:UO_0000325 biolink:NamedThing megaHertz RBO_relaxed.owl OBO:UO_1000106 biolink:NamedThing hertz based unit RBO_relaxed.owl OBO:UO_0000061 biolink:NamedThing unit of molarity RBO_relaxed.owl OBO:UO_0000067 biolink:NamedThing unit of molality RBO_relaxed.owl OBO:UO_0000074 biolink:NamedThing unit of normality RBO_relaxed.owl OBO:UO_0000177 biolink:NamedThing unit per volume unit RBO_relaxed.owl OBO:UO_0000200 biolink:NamedThing cell concentration unit RBO_relaxed.owl OBO:UO_0000202 biolink:NamedThing catalytic (activity) concentration unit RBO_relaxed.owl OBO:UO_0000205 biolink:NamedThing volume per unit volume RBO_relaxed.owl OBO:UO_0000212 biolink:NamedThing colony forming unit per volume A concentration unit which a measure of viable bacterial numbers in a given volume. RBO_relaxed.owl OBO:UO_0000214 biolink:NamedThing plaque forming unit per volume RBO_relaxed.owl OBO:UO_0000307 biolink:NamedThing dose unit RBO_relaxed.owl OBO:UO_1000076 biolink:NamedThing mole fraction based unit RBO_relaxed.owl OBO:UO_1000163 biolink:NamedThing mass percentage based unit RBO_relaxed.owl OBO:UO_1000164 biolink:NamedThing mass volume percentage based unit RBO_relaxed.owl OBO:UO_1000180 biolink:NamedThing mass per unit volume based unit RBO_relaxed.owl OBO:UO_1000196 biolink:NamedThing pH based unit RBO_relaxed.owl OBO:UO_1000310 biolink:NamedThing dosage unit based unit RBO_relaxed.owl OBO:UO_0000062 biolink:NamedThing molar A unit of concentration which expresses a concentration of 1 mole of solute per liter of solution (mol/L). RBO_relaxed.owl OBO:UO_1000062 biolink:NamedThing molar based unit RBO_relaxed.owl OBO:UO_0000063 biolink:NamedThing millimolar A unit of molarity which is equal to one thousandth of a molar or 10^[-3] M. RBO_relaxed.owl OBO:UO_0000064 biolink:NamedThing micromolar A unit of molarity which is equal to one millionth of a molar or 10^[-6] M. RBO_relaxed.owl OBO:UO_0000065 biolink:NamedThing nanomolar A unit of molarity which is equal to one thousandth of one millionth of a molar or 10^[-9] M. RBO_relaxed.owl OBO:UO_0000066 biolink:NamedThing picomolar A unit of molarity which is equal to 10^[-12] M. RBO_relaxed.owl OBO:UO_0000073 biolink:NamedThing femtomolar RBO_relaxed.owl OBO:UO_0000068 biolink:NamedThing molal RBO_relaxed.owl OBO:UO_1000068 biolink:NamedThing molal based unit RBO_relaxed.owl OBO:UO_0000069 biolink:NamedThing millimolal RBO_relaxed.owl OBO:UO_0000070 biolink:NamedThing micromolal RBO_relaxed.owl OBO:UO_0000071 biolink:NamedThing nanomolal RBO_relaxed.owl OBO:UO_0000072 biolink:NamedThing picomolal RBO_relaxed.owl OBO:UO_0000075 biolink:NamedThing normal RBO_relaxed.owl OBO:UO_1000075 biolink:NamedThing normal based unit RBO_relaxed.owl OBO:UO_0000076 biolink:NamedThing mole fraction RBO_relaxed.owl OBO:UO_0000077 biolink:NamedThing meter per second per second RBO_relaxed.owl OBO:UO_1000077 biolink:NamedThing meter per second per second based unit RBO_relaxed.owl OBO:UO_0000078 biolink:NamedThing radian per second per second RBO_relaxed.owl OBO:UO_1000078 biolink:NamedThing radian per second per second based unit RBO_relaxed.owl OBO:UO_0000079 biolink:NamedThing radian per second RBO_relaxed.owl OBO:UO_1000079 biolink:NamedThing radian per second based unit RBO_relaxed.owl OBO:UO_0000080 biolink:NamedThing square meter RBO_relaxed.owl OBO:UO_1000080 biolink:NamedThing square meter based unit RBO_relaxed.owl OBO:UO_0000081 biolink:NamedThing square centimeter RBO_relaxed.owl OBO:UO_1000081 biolink:NamedThing square centimeter based unit RBO_relaxed.owl OBO:UO_0000082 biolink:NamedThing square millimeter RBO_relaxed.owl OBO:UO_1000082 biolink:NamedThing square millimeter based unit RBO_relaxed.owl OBO:UO_0000083 biolink:NamedThing kilogram per cubic meter RBO_relaxed.owl OBO:UO_0010050 biolink:NamedThing nanogram per microliter RBO_relaxed.owl OBO:UO_0010053 biolink:NamedThing micrograms per wheaton bottle RBO_relaxed.owl OBO:UO_1000084 biolink:NamedThing gram per cubic centimeter based unit RBO_relaxed.owl OBO:UO_1000173 biolink:NamedThing gram per milliliter based unit RBO_relaxed.owl OBO:UO_1000175 biolink:NamedThing gram per liter based unit RBO_relaxed.owl OBO:UO_1000208 biolink:NamedThing gram per deciliter based unit RBO_relaxed.owl OBO:UO_0000084 biolink:NamedThing gram per cubic centimeter RBO_relaxed.owl OBO:UO_0000085 biolink:NamedThing candela per square meter RBO_relaxed.owl OBO:UO_1000085 biolink:NamedThing candela per square meter based unit RBO_relaxed.owl OBO:UO_0000086 biolink:NamedThing kilogram per square meter RBO_relaxed.owl OBO:UO_1010049 biolink:NamedThing gram per square meter based unit RBO_relaxed.owl OBO:UO_0000309 biolink:NamedThing milligram per square meter RBO_relaxed.owl OBO:UO_0010049 biolink:NamedThing gram per square meter RBO_relaxed.owl OBO:UO_0000087 biolink:NamedThing kilogram per mole RBO_relaxed.owl OBO:UO_1000088 biolink:NamedThing gram per mole based unit RBO_relaxed.owl OBO:UO_0000088 biolink:NamedThing gram per mole RBO_relaxed.owl OBO:UO_0000089 biolink:NamedThing cubic meter per mole RBO_relaxed.owl OBO:UO_1000089 biolink:NamedThing cubic meter per mole based unit RBO_relaxed.owl OBO:UO_0000090 biolink:NamedThing cubic centimeter per mole RBO_relaxed.owl OBO:UO_1000090 biolink:NamedThing cubic centimeter per mole based unit RBO_relaxed.owl OBO:UO_0000091 biolink:NamedThing kilogram meter per second RBO_relaxed.owl OBO:UO_0000092 biolink:NamedThing turns per second RBO_relaxed.owl OBO:UO_1000092 biolink:NamedThing turns per second based unit RBO_relaxed.owl OBO:UO_0000093 biolink:NamedThing cubic meter per kilogram RBO_relaxed.owl OBO:UO_1000093 biolink:NamedThing cubic meter per kilogram based unit RBO_relaxed.owl OBO:UO_0000094 biolink:NamedThing meter per second RBO_relaxed.owl OBO:UO_1000094 biolink:NamedThing meter per second based unit RBO_relaxed.owl OBO:UO_0000096 biolink:NamedThing cubic meter RBO_relaxed.owl OBO:UO_0000097 biolink:NamedThing cubic centimeter A volume unit which is equal to one millionth of a cubic meter or 10^[-9] m^[3], or to 1 ml. RBO_relaxed.owl OBO:UO_0000098 biolink:NamedThing milliliter A volume unit which is equal to one thousandth of a liter or 10^[-3] L, or to 1 cubic centimeter. RBO_relaxed.owl OBO:UO_0000099 biolink:NamedThing liter A volume unit which is equal to one thousandth of a cubic meter or 10^[-3] m^[3], or to 1 decimeter. RBO_relaxed.owl OBO:UO_0000101 biolink:NamedThing microliter A volume unit which is equal to one millionth of a liter or 10^[-6] L. RBO_relaxed.owl OBO:UO_0000102 biolink:NamedThing nanoliter A volume unit which is equal to one thousandth of one millionth of a liter or 10^[-9] L. RBO_relaxed.owl OBO:UO_0000103 biolink:NamedThing picoliter A volume unit which is equal to 10^[-12] L. RBO_relaxed.owl OBO:UO_0000104 biolink:NamedThing femtoliter RBO_relaxed.owl OBO:UO_0000209 biolink:NamedThing deciliter RBO_relaxed.owl OBO:UO_0000100 biolink:NamedThing cubic decimeter A volume unit which is equal to one thousand of a cubic meter or 10^[-3] m^[3], or to 1 L. RBO_relaxed.owl OBO:UO_0000106 biolink:NamedThing hertz A frequency unit which is equal to 1 complete cycle of a recurring phenomenon in 1 second. RBO_relaxed.owl OBO:UO_0000108 biolink:NamedThing newton RBO_relaxed.owl OBO:UO_1000108 biolink:NamedThing newton based unit RBO_relaxed.owl OBO:UO_0000110 biolink:NamedThing pascal RBO_relaxed.owl OBO:UO_1000110 biolink:NamedThing pascal based unit RBO_relaxed.owl OBO:UO_0000112 biolink:NamedThing joule RBO_relaxed.owl OBO:UO_1000112 biolink:NamedThing joule based unit RBO_relaxed.owl OBO:UO_0000114 biolink:NamedThing watt RBO_relaxed.owl OBO:UO_1000114 biolink:NamedThing watt based unit RBO_relaxed.owl OBO:UO_0000116 biolink:NamedThing lux RBO_relaxed.owl OBO:UO_1000116 biolink:NamedThing lux based unit RBO_relaxed.owl OBO:UO_0000118 biolink:NamedThing lumen RBO_relaxed.owl OBO:UO_1000118 biolink:NamedThing lumen based unit RBO_relaxed.owl OBO:UO_0000120 biolink:NamedThing katal RBO_relaxed.owl OBO:UO_1000120 biolink:NamedThing katal based unit RBO_relaxed.owl OBO:UO_0000122 biolink:NamedThing plane angle unit RBO_relaxed.owl OBO:UO_0000124 biolink:NamedThing solid angle unit RBO_relaxed.owl OBO:UO_0000123 biolink:NamedThing radian RBO_relaxed.owl OBO:UO_1000123 biolink:NamedThing radian based unit RBO_relaxed.owl OBO:UO_0000125 biolink:NamedThing steradian RBO_relaxed.owl OBO:UO_1000125 biolink:NamedThing steradian based unit RBO_relaxed.owl OBO:UO_0000128 biolink:NamedThing activity (of a radionuclide) unit RBO_relaxed.owl OBO:UO_0000130 biolink:NamedThing dose equivalent unit RBO_relaxed.owl OBO:UO_0000131 biolink:NamedThing exposure unit RBO_relaxed.owl OBO:UO_1000260 biolink:NamedThing effective dose unit based unit RBO_relaxed.owl OBO:UO_0000132 biolink:NamedThing becquerel RBO_relaxed.owl OBO:UO_1000132 biolink:NamedThing becquerel based unit RBO_relaxed.owl OBO:UO_0000133 biolink:NamedThing curie RBO_relaxed.owl OBO:UO_1000133 biolink:NamedThing curie based unit RBO_relaxed.owl OBO:UO_0000145 biolink:NamedThing millicurie RBO_relaxed.owl OBO:UO_0000146 biolink:NamedThing microcurie RBO_relaxed.owl OBO:UO_0000134 biolink:NamedThing gray RBO_relaxed.owl OBO:UO_0000141 biolink:NamedThing microgray RBO_relaxed.owl OBO:UO_0000142 biolink:NamedThing milligray RBO_relaxed.owl OBO:UO_0000143 biolink:NamedThing nanogray RBO_relaxed.owl OBO:UO_0010055 biolink:NamedThing centigray RBO_relaxed.owl OBO:UO_0000136 biolink:NamedThing roentgen RBO_relaxed.owl OBO:UO_1000136 biolink:NamedThing roentgen based unit RBO_relaxed.owl OBO:UO_0000137 biolink:NamedThing sievert RBO_relaxed.owl OBO:UO_1000137 biolink:NamedThing sievert based unit RBO_relaxed.owl OBO:UO_0000138 biolink:NamedThing millisievert RBO_relaxed.owl OBO:UO_0000139 biolink:NamedThing microsievert RBO_relaxed.owl OBO:UO_0000144 biolink:NamedThing nanosievert RBO_relaxed.owl OBO:UO_0000140 biolink:NamedThing Roentgen equivalent man RBO_relaxed.owl OBO:UO_1000140 biolink:NamedThing Roentgen equivalent man based unit RBO_relaxed.owl OBO:UO_0000147 biolink:NamedThing disintegrations per minute RBO_relaxed.owl OBO:UO_1000147 biolink:NamedThing disintegrations per minute based unit RBO_relaxed.owl OBO:UO_0000148 biolink:NamedThing counts per minute RBO_relaxed.owl OBO:UO_1000148 biolink:NamedThing counts per minute based unit RBO_relaxed.owl OBO:UO_0000151 biolink:NamedThing century RBO_relaxed.owl OBO:UO_1000151 biolink:NamedThing century based unit RBO_relaxed.owl OBO:UO_0000152 biolink:NamedThing half life RBO_relaxed.owl OBO:UO_1000152 biolink:NamedThing half life based unit RBO_relaxed.owl OBO:UO_0000153 biolink:NamedThing foot candle RBO_relaxed.owl OBO:UO_1000153 biolink:NamedThing foot candle based unit RBO_relaxed.owl OBO:UO_0000155 biolink:NamedThing watt per square meter RBO_relaxed.owl OBO:UO_1000155 biolink:NamedThing watt per square meter based unit RBO_relaxed.owl OBO:UO_0000156 biolink:NamedThing einstein per square meter per second RBO_relaxed.owl OBO:UO_1000156 biolink:NamedThing einstein per square meter per second based unit RBO_relaxed.owl OBO:UO_0000160 biolink:NamedThing microeinstein per square meter per second RBO_relaxed.owl OBO:UO_0000158 biolink:NamedThing watt per steradian per square meter RBO_relaxed.owl OBO:UO_1000158 biolink:NamedThing watt per steradian per square meter based unit RBO_relaxed.owl OBO:UO_0000162 biolink:NamedThing watt per steradian RBO_relaxed.owl OBO:UO_1000162 biolink:NamedThing watt per steradian based unit RBO_relaxed.owl OBO:UO_0000163 biolink:NamedThing mass percentage A dimensionless concentration unit which denotes the mass of a substance in a mixture as a percentage of the mass of the entire mixture. RBO_relaxed.owl OBO:UO_0000164 biolink:NamedThing mass volume percentage A dimensionless concentration unit which denotes the mass of the substance in a mixture as a percentage of the volume of the entire mixture. RBO_relaxed.owl OBO:UO_0000165 biolink:NamedThing volume percentage A dimensionless concentration unit which denotes the volume of the solute in mL per 100 mL of the resulting solution. RBO_relaxed.owl OBO:UO_1000165 biolink:NamedThing volume percentage based unit RBO_relaxed.owl OBO:UO_0000166 biolink:NamedThing parts per notation unit RBO_relaxed.owl OBO:UO_0000189 biolink:NamedThing count unit RBO_relaxed.owl OBO:UO_0000190 biolink:NamedThing ratio unit RBO_relaxed.owl OBO:UO_1000188 biolink:NamedThing pi based unit RBO_relaxed.owl OBO:UO_1000269 biolink:NamedThing absorbance unit based unit RBO_relaxed.owl OBO:UO_0000167 biolink:NamedThing parts per hundred RBO_relaxed.owl OBO:UO_1000167 biolink:NamedThing parts per hundred based unit RBO_relaxed.owl OBO:UO_0000168 biolink:NamedThing parts per thousand RBO_relaxed.owl OBO:UO_1000168 biolink:NamedThing parts per thousand based unit RBO_relaxed.owl OBO:UO_0000169 biolink:NamedThing parts per million RBO_relaxed.owl OBO:UO_1000169 biolink:NamedThing parts per million based unit RBO_relaxed.owl OBO:UO_0000170 biolink:NamedThing parts per billion RBO_relaxed.owl OBO:UO_1000170 biolink:NamedThing parts per billion based unit RBO_relaxed.owl OBO:UO_0000171 biolink:NamedThing parts per trillion RBO_relaxed.owl OBO:UO_1000171 biolink:NamedThing parts per trillion based unit RBO_relaxed.owl OBO:UO_0000172 biolink:NamedThing parts per quadrillion RBO_relaxed.owl OBO:UO_1000172 biolink:NamedThing parts per quadrillion based unit RBO_relaxed.owl OBO:UO_0000173 biolink:NamedThing gram per milliliter RBO_relaxed.owl OBO:UO_0000274 biolink:NamedThing microgram per milliliter RBO_relaxed.owl OBO:UO_0000275 biolink:NamedThing nanogram per milliliter RBO_relaxed.owl OBO:UO_0000174 biolink:NamedThing kilogram per liter RBO_relaxed.owl OBO:UO_0000175 biolink:NamedThing gram per liter A mass unit density which is equal to mass of an object in grams divided by the volume in liters. RBO_relaxed.owl OBO:UO_0000176 biolink:NamedThing milligram per milliliter A mass unit density which is equal to mass of an object in milligrams divided by the volume in milliliters. RBO_relaxed.owl OBO:UO_0000273 biolink:NamedThing milligram per liter RBO_relaxed.owl OBO:UO_0000301 biolink:NamedThing microgram per liter A mass unit density which is equal to mass of an object in micrograms divided by the volume in liters. RBO_relaxed.owl OBO:UO_0000178 biolink:NamedThing unit per milliliter RBO_relaxed.owl OBO:UO_1000178 biolink:NamedThing unit per milliliter based unit RBO_relaxed.owl OBO:UO_0000179 biolink:NamedThing unit per liter RBO_relaxed.owl OBO:UO_1000179 biolink:NamedThing unit per liter based unit RBO_relaxed.owl OBO:UO_0000180 biolink:NamedThing mass per unit volume RBO_relaxed.owl OBO:UO_0000181 biolink:NamedThing enzyme unit RBO_relaxed.owl OBO:UO_1000181 biolink:NamedThing enzyme unit based unit RBO_relaxed.owl OBO:UO_0000184 biolink:NamedThing kilogram per meter RBO_relaxed.owl OBO:UO_0000185 biolink:NamedThing degree RBO_relaxed.owl OBO:UO_1000185 biolink:NamedThing degree based unit RBO_relaxed.owl OBO:UO_0000187 biolink:NamedThing percent RBO_relaxed.owl OBO:UO_0000191 biolink:NamedThing fraction RBO_relaxed.owl OBO:UO_0000259 biolink:NamedThing decibel RBO_relaxed.owl OBO:UO_0000188 biolink:NamedThing pi RBO_relaxed.owl OBO:UO_0000192 biolink:NamedThing molecule count RBO_relaxed.owl OBO:UO_1000192 biolink:NamedThing molecule count based unit RBO_relaxed.owl OBO:UO_0000193 biolink:NamedThing purity percentage RBO_relaxed.owl OBO:UO_1000193 biolink:NamedThing purity percentage based unit RBO_relaxed.owl OBO:UO_0000194 biolink:NamedThing confluence percentage RBO_relaxed.owl OBO:UO_1000194 biolink:NamedThing confluence percentage based unit RBO_relaxed.owl OBO:UO_0000195 biolink:NamedThing degree Fahrenheit A temperature unit which is equal to 5/9ths of a kelvin. Negative 40 degrees Fahrenheit is equal to negative 40 degrees Celsius. RBO_relaxed.owl OBO:UO_1000195 biolink:NamedThing degree Fahrenheit based unit RBO_relaxed.owl OBO:UO_0000196 biolink:NamedThing pH A dimensionless concentration notation which denotes the acidity of a solution in terms of activity of hydrogen ions (H+). RBO_relaxed.owl OBO:UO_0000197 biolink:NamedThing liter per kilogram RBO_relaxed.owl OBO:UO_1000197 biolink:NamedThing liter per kilogram based unit RBO_relaxed.owl OBO:UO_0000198 biolink:NamedThing milliliter per kilogram RBO_relaxed.owl OBO:UO_0000199 biolink:NamedThing microliter per kilogram RBO_relaxed.owl OBO:UO_0000201 biolink:NamedThing cells per milliliter RBO_relaxed.owl OBO:UO_1000201 biolink:NamedThing cells per milliliter based unit RBO_relaxed.owl OBO:UO_0000203 biolink:NamedThing katal per cubic meter RBO_relaxed.owl OBO:UO_1000203 biolink:NamedThing katal per cubic meter based unit RBO_relaxed.owl OBO:UO_0000204 biolink:NamedThing katal per liter RBO_relaxed.owl OBO:UO_1000204 biolink:NamedThing katal per liter based unit RBO_relaxed.owl OBO:UO_0000206 biolink:NamedThing milliliter per cubic meter RBO_relaxed.owl OBO:UO_0000207 biolink:NamedThing milliliter per liter A volume per unit volume unit which is equal to one millionth of a liter of solute in one liter of solution. RBO_relaxed.owl OBO:UO_0000208 biolink:NamedThing gram per deciliter A mass density unit which is equal to mass of an object in grams divided by the volume in deciliters. RBO_relaxed.owl OBO:UO_0010067 biolink:NamedThing milligram per deciliter RBO_relaxed.owl OBO:UO_0010068 biolink:NamedThing microgram per deciliter RBO_relaxed.owl OBO:UO_0000210 biolink:NamedThing colony forming unit RBO_relaxed.owl OBO:UO_1000210 biolink:NamedThing colony forming unit based unit RBO_relaxed.owl OBO:UO_0000211 biolink:NamedThing plaque forming unit RBO_relaxed.owl OBO:UO_1000211 biolink:NamedThing plaque forming unit based unit RBO_relaxed.owl OBO:UO_0000213 biolink:NamedThing colony forming unit per milliliter RBO_relaxed.owl OBO:UO_1000213 biolink:NamedThing colony forming unit per milliliter based unit RBO_relaxed.owl OBO:UO_0000215 biolink:NamedThing plaque forming unit per milliliter RBO_relaxed.owl OBO:UO_1000215 biolink:NamedThing plaque forming unit per milliliter based unit RBO_relaxed.owl OBO:UO_0000216 biolink:NamedThing disintegrations per second RBO_relaxed.owl OBO:UO_1000216 biolink:NamedThing disintegrations per second based unit RBO_relaxed.owl OBO:UO_0000218 biolink:NamedThing volt RBO_relaxed.owl OBO:UO_1000218 biolink:NamedThing volt based unit RBO_relaxed.owl OBO:UO_0000247 biolink:NamedThing millivolt RBO_relaxed.owl OBO:UO_0000248 biolink:NamedThing kilovolt RBO_relaxed.owl OBO:UO_0000249 biolink:NamedThing microvolt RBO_relaxed.owl OBO:UO_0000250 biolink:NamedThing nanovolt RBO_relaxed.owl OBO:UO_0000251 biolink:NamedThing picovolt RBO_relaxed.owl OBO:UO_0000252 biolink:NamedThing megavolt RBO_relaxed.owl OBO:UO_0000220 biolink:NamedThing coulomb RBO_relaxed.owl OBO:UO_0000221 biolink:NamedThing dalton RBO_relaxed.owl OBO:UO_0000222 biolink:NamedThing kilodalton RBO_relaxed.owl OBO:UO_0000223 biolink:NamedThing watt-hour RBO_relaxed.owl OBO:UO_1000223 biolink:NamedThing watt-hour based unit RBO_relaxed.owl OBO:UO_0000224 biolink:NamedThing kilowatt-hour RBO_relaxed.owl OBO:UO_0000226 biolink:NamedThing weber RBO_relaxed.owl OBO:UO_1000226 biolink:NamedThing weber based unit RBO_relaxed.owl OBO:UO_0000228 biolink:NamedThing tesla RBO_relaxed.owl OBO:UO_1000228 biolink:NamedThing tesla based unit RBO_relaxed.owl OBO:UO_0000229 biolink:NamedThing volt-hour RBO_relaxed.owl OBO:UO_1000229 biolink:NamedThing volt-hour based unit RBO_relaxed.owl OBO:UO_0000230 biolink:NamedThing kilovolt-hour RBO_relaxed.owl OBO:UO_0000232 biolink:NamedThing bit RBO_relaxed.owl OBO:UO_1000232 biolink:NamedThing bit based unit RBO_relaxed.owl OBO:UO_0000233 biolink:NamedThing byte RBO_relaxed.owl OBO:UO_1000233 biolink:NamedThing byte based unit RBO_relaxed.owl OBO:UO_0000234 biolink:NamedThing kilobyte RBO_relaxed.owl OBO:UO_0000235 biolink:NamedThing megabyte RBO_relaxed.owl OBO:UO_0000236 biolink:NamedThing image resolution unit RBO_relaxed.owl OBO:UO_1000245 biolink:NamedThing kibibyte based unit RBO_relaxed.owl OBO:UO_1000246 biolink:NamedThing mebibyte based unit RBO_relaxed.owl OBO:UO_0000237 biolink:NamedThing chroma sampling unit RBO_relaxed.owl OBO:UO_1000237 biolink:NamedThing chroma sampling unit based unit RBO_relaxed.owl OBO:UO_0000238 biolink:NamedThing dynamic range unit RBO_relaxed.owl OBO:UO_1000238 biolink:NamedThing dynamic range unit based unit RBO_relaxed.owl OBO:UO_0000239 biolink:NamedThing spatial resolution unit RBO_relaxed.owl OBO:UO_0000240 biolink:NamedThing dots per inch RBO_relaxed.owl OBO:UO_1000240 biolink:NamedThing dots per inch based unit RBO_relaxed.owl OBO:UO_0000241 biolink:NamedThing micron pixel RBO_relaxed.owl OBO:UO_1000242 biolink:NamedThing pixels per inch based unit RBO_relaxed.owl OBO:UO_1000243 biolink:NamedThing pixels per millimeter based unit RBO_relaxed.owl OBO:UO_0000242 biolink:NamedThing pixels per inch RBO_relaxed.owl OBO:UO_0000243 biolink:NamedThing pixels per millimeter RBO_relaxed.owl OBO:UO_0000244 biolink:NamedThing base pair RBO_relaxed.owl OBO:UO_1000244 biolink:NamedThing base pair based unit RBO_relaxed.owl OBO:UO_0000329 biolink:NamedThing mega base pair RBO_relaxed.owl OBO:UO_0000330 biolink:NamedThing giga base pair RBO_relaxed.owl OBO:UO_0000245 biolink:NamedThing kibibyte RBO_relaxed.owl OBO:UO_0000246 biolink:NamedThing mebibyte RBO_relaxed.owl OBO:UO_0000254 biolink:NamedThing newton per meter RBO_relaxed.owl OBO:UO_1000254 biolink:NamedThing newton per meter based unit RBO_relaxed.owl OBO:UO_0000255 biolink:NamedThing dyne per cm RBO_relaxed.owl OBO:UO_1000255 biolink:NamedThing dyne per cm based unit RBO_relaxed.owl OBO:UO_0000257 biolink:NamedThing pascal second RBO_relaxed.owl OBO:UO_1000257 biolink:NamedThing pascal second based unit RBO_relaxed.owl OBO:UO_0000258 biolink:NamedThing poise RBO_relaxed.owl OBO:UO_1000258 biolink:NamedThing poise based unit RBO_relaxed.owl OBO:UO_0000260 biolink:NamedThing effective dose unit RBO_relaxed.owl OBO:UO_0000262 biolink:NamedThing electrical conduction unit RBO_relaxed.owl OBO:UO_0000263 biolink:NamedThing heat conduction unit RBO_relaxed.owl OBO:UO_0000264 biolink:NamedThing siemens RBO_relaxed.owl OBO:UO_1000264 biolink:NamedThing siemens based unit RBO_relaxed.owl OBO:UO_0010002 biolink:NamedThing millisiemens RBO_relaxed.owl OBO:UO_0000265 biolink:NamedThing watt per meter kelvin RBO_relaxed.owl OBO:UO_1000265 biolink:NamedThing watt per meter kelvin based unit RBO_relaxed.owl OBO:UO_0000266 biolink:NamedThing electronvolt RBO_relaxed.owl OBO:UO_1000266 biolink:NamedThing electronvolt based unit RBO_relaxed.owl OBO:UO_0010056 biolink:NamedThing gigaelectronvolt RBO_relaxed.owl OBO:UO_0000268 biolink:NamedThing volt per meter RBO_relaxed.owl OBO:UO_1000268 biolink:NamedThing volt per meter based unit RBO_relaxed.owl OBO:UO_0000269 biolink:NamedThing absorbance unit RBO_relaxed.owl OBO:UO_0000271 biolink:NamedThing microliters per minute A volumetric flow rate unit which is equal to one microliter volume through a given surface in one minute. RBO_relaxed.owl OBO:UO_0000272 biolink:NamedThing millimetres of mercury RBO_relaxed.owl OBO:UO_0000279 biolink:NamedThing milliunits per milliliter RBO_relaxed.owl OBO:UO_0000281 biolink:NamedThing count per nanomolar second A rate unit which is equal to one over one nanomolar second. RBO_relaxed.owl OBO:UO_1000281 biolink:NamedThing count per nanomolar second based unit RBO_relaxed.owl OBO:UO_0000282 biolink:NamedThing count per molar second A rate unit which is equal to one over one molar second. RBO_relaxed.owl OBO:UO_1000282 biolink:NamedThing count per molar second based unit RBO_relaxed.owl OBO:UO_0000283 biolink:NamedThing kilogram per hectare RBO_relaxed.owl OBO:UO_0000284 biolink:NamedThing count per nanomolar A rate unit which is equal to one over one nanomolar. RBO_relaxed.owl OBO:UO_1000284 biolink:NamedThing count per nanomolar based unit RBO_relaxed.owl OBO:UO_0000285 biolink:NamedThing count per molar A rate unit which is equal to one over one molar. RBO_relaxed.owl OBO:UO_1000285 biolink:NamedThing count per molar based unit RBO_relaxed.owl OBO:UO_0000292 biolink:NamedThing giga RBO_relaxed.owl OBO:UO_0000293 biolink:NamedThing mega RBO_relaxed.owl OBO:UO_0000294 biolink:NamedThing kilo RBO_relaxed.owl OBO:UO_0000296 biolink:NamedThing deci RBO_relaxed.owl OBO:UO_0000297 biolink:NamedThing milli RBO_relaxed.owl OBO:UO_0000298 biolink:NamedThing centi RBO_relaxed.owl OBO:UO_0000299 biolink:NamedThing micro RBO_relaxed.owl OBO:UO_0000300 biolink:NamedThing nano RBO_relaxed.owl OBO:UO_0000302 biolink:NamedThing pico RBO_relaxed.owl OBO:UO_0000303 biolink:NamedThing femto RBO_relaxed.owl OBO:UO_0000304 biolink:NamedThing atto RBO_relaxed.owl OBO:UO_0000308 biolink:NamedThing milligram per kilogram RBO_relaxed.owl OBO:UO_0000310 biolink:NamedThing dosage unit RBO_relaxed.owl OBO:UO_0000312 biolink:NamedThing relative light unit RBO_relaxed.owl OBO:UO_0000313 biolink:NamedThing relative luminescence unit RBO_relaxed.owl OBO:UO_1000313 biolink:NamedThing relative luminescence unit based unit RBO_relaxed.owl OBO:UO_0000314 biolink:NamedThing relative fluorescence unit RBO_relaxed.owl OBO:UO_1000314 biolink:NamedThing relative fluorescence unit based unit RBO_relaxed.owl OBO:UO_0000326 biolink:NamedThing centiMorgan RBO_relaxed.owl OBO:UO_0000327 biolink:NamedThing centiRay RBO_relaxed.owl OBO:UO_1010011 biolink:NamedThing inch based unit RBO_relaxed.owl OBO:UO_1010012 biolink:NamedThing thou based unit RBO_relaxed.owl OBO:UO_1010013 biolink:NamedThing foot based unit RBO_relaxed.owl OBO:UO_1010014 biolink:NamedThing yard based unit RBO_relaxed.owl OBO:UO_1010015 biolink:NamedThing chain based unit RBO_relaxed.owl OBO:UO_1010016 biolink:NamedThing furlong based unit RBO_relaxed.owl OBO:UO_1010017 biolink:NamedThing mile based unit RBO_relaxed.owl OBO:UO_1010018 biolink:NamedThing league based unit RBO_relaxed.owl OBO:UO_1010019 biolink:NamedThing maritime length unit based unit RBO_relaxed.owl OBO:UO_0010001 biolink:NamedThing square micrometer RBO_relaxed.owl OBO:UO_1010001 biolink:NamedThing square micrometer based unit RBO_relaxed.owl OBO:UO_0010003 biolink:NamedThing micromole per litre RBO_relaxed.owl OBO:UO_0010004 biolink:NamedThing micromole per kilogram RBO_relaxed.owl OBO:UO_0010005 biolink:NamedThing millimeters per day RBO_relaxed.owl OBO:UO_0010008 biolink:NamedThing kilometer per hour RBO_relaxed.owl OBO:UO_0010010 biolink:NamedThing hectare RBO_relaxed.owl OBO:UO_1010010 biolink:NamedThing hectare based unit RBO_relaxed.owl OBO:UO_0010019 biolink:NamedThing maritime length unit RBO_relaxed.owl OBO:UO_0010020 biolink:NamedThing fathom RBO_relaxed.owl OBO:UO_1010020 biolink:NamedThing fathom based unit RBO_relaxed.owl OBO:UO_0010021 biolink:NamedThing cable RBO_relaxed.owl OBO:UO_1010021 biolink:NamedThing cable based unit RBO_relaxed.owl OBO:UO_0010022 biolink:NamedThing nautical mile RBO_relaxed.owl OBO:UO_1010022 biolink:NamedThing nautical mile based unit RBO_relaxed.owl OBO:UO_0010023 biolink:NamedThing perch RBO_relaxed.owl OBO:UO_1010023 biolink:NamedThing perch based unit RBO_relaxed.owl OBO:UO_0010024 biolink:NamedThing rood RBO_relaxed.owl OBO:UO_1010024 biolink:NamedThing rood based unit RBO_relaxed.owl OBO:UO_0010025 biolink:NamedThing acre RBO_relaxed.owl OBO:UO_1010025 biolink:NamedThing acre based unit RBO_relaxed.owl OBO:UO_0010026 biolink:NamedThing fluid ounce RBO_relaxed.owl OBO:UO_0010027 biolink:NamedThing gill RBO_relaxed.owl OBO:UO_0010028 biolink:NamedThing pint RBO_relaxed.owl OBO:UO_0010029 biolink:NamedThing quart RBO_relaxed.owl OBO:UO_0010030 biolink:NamedThing gallon RBO_relaxed.owl OBO:UO_0010031 biolink:NamedThing grain RBO_relaxed.owl OBO:UO_0010032 biolink:NamedThing drachm RBO_relaxed.owl OBO:UO_0010033 biolink:NamedThing ounce RBO_relaxed.owl OBO:UO_0010034 biolink:NamedThing pound RBO_relaxed.owl OBO:UO_0010035 biolink:NamedThing stone RBO_relaxed.owl OBO:UO_0010036 biolink:NamedThing quarter RBO_relaxed.owl OBO:UO_0010037 biolink:NamedThing hundredweight RBO_relaxed.owl OBO:UO_0010038 biolink:NamedThing ton RBO_relaxed.owl OBO:UO_0010039 biolink:NamedThing slug RBO_relaxed.owl OBO:UO_1010039 biolink:NamedThing slug based unit RBO_relaxed.owl OBO:UO_0010040 biolink:NamedThing teaspoon RBO_relaxed.owl OBO:UO_0010051 biolink:NamedThing large calorie RBO_relaxed.owl OBO:UO_1010051 biolink:NamedThing large calorie based unit RBO_relaxed.owl OBO:UO_0010057 biolink:NamedThing gigaelectronvolt per nucleon RBO_relaxed.owl OBO:UO_0010058 biolink:NamedThing megaelectronvolt per nucleon RBO_relaxed.owl OBO:UO_0010059 biolink:NamedThing kiloelectronvolt per micron RBO_relaxed.owl OBO:UO_0010060 biolink:NamedThing gray per minute RBO_relaxed.owl OBO:UO_0010061 biolink:NamedThing centigray per minute RBO_relaxed.owl OBO:UO_0010062 biolink:NamedThing milligray per minute RBO_relaxed.owl EFO:0000597 biolink:NamedThing 129 mouse strain 129 is a mouse strain as described in Jackson Laboratory http://www.informatics.jax.org/mgihome/nomen/strain_129.shtml RBO_relaxed.owl EFO:0000602 biolink:NamedThing BALB/c BALB/c is a mouse strain of albion mice. RBO_relaxed.owl EFO:0000603 biolink:NamedThing BALB/cByJ BALB is a mouse strain as described in Jackson Laboratory http://jaxmice.jax.org/strain/001026.html RBO_relaxed.owl EFO:0001327 biolink:NamedThing A/J A/J is a mouse strain as described in Jackson Laboratory http://jaxmice.jax.org/strain/000646.html RBO_relaxed.owl EFO:0001329 biolink:NamedThing C3H/HeJ C3H/HeJ is a mouse strain as described in Jackson Laboratory http://jaxmice.jax.org/strain/000659.html RBO_relaxed.owl EFO:0001339 biolink:NamedThing CB6F1 CB6F1 is a mouse strain as described in Jackson Laboratory http://jaxmice.jax.org/strain/100007.html RBO_relaxed.owl EFO:0001340 biolink:NamedThing B6C3F1 B6C3F1 is a mouse strain as described in Jackson Laboratory http://jaxmice.jax.org/strain/100010.html RBO_relaxed.owl EFO:0003013 biolink:NamedThing Mus musculus subspecies RBO_relaxed.owl EFO:0004000 biolink:NamedThing Mus musculus strain type A designator of mouse strain information indicating the genetic homo or heterogenetity e.g. inbred strain RBO_relaxed.owl EFO:0005180 biolink:NamedThing CD1 mus strain The original group of Swiss mice that served as progenitors of this stock consisted of two male and seven female albino mice derived from a non-inbred stock in the laboratory of Dr. de Coulon, Centre Anticancereux Romand, Lausanne, Switzerland. RBO_relaxed.owl EFO:0007726 biolink:NamedThing AKR/J Originally inbred at the Rockefeller Institute, AKR mice are widely used in cancer research for their high leukemia incidence (60-90%) and in immunology as a source of the Thy1.1 (theta AKR) antigen. AKR/J mice are viremic from birth, and express the ecotropic retrovirus AKV in all tissues. The hair interior defect (hid) mutation, a strain characteristic of AKR mice, causes alterations in hair development that is only evident microscopically. Adrenocortical lipid depletion (ald) in AKR mice is caused by a mutation in sterol O-acyltransferase 1 (Soat1), and leads to a truncated SOAT1 protein. AKR/J mice are relatively resistant to aortic lesion formation on a semi-synthetic high fat diet and are hyporesponsive to diets containing high levels of fat and cholesterol. RBO_relaxed.owl EFO:0007727 biolink:NamedThing CAST/EiJ Both CAST/EiJ and CASA/RkJ (Stock No. 000735) were derived from wild mice trapped in Thailand. CAST is often combined with the common laboratory strains to generate F1 hybrids with high levels of heterozygosity for use in genetic mapping. Unlike the wild-derived strain SPRET, male F1 mice from a CAST cross are fertile. Like CASA, CAST is resistant to flavivirus infection. The flavivirus family includes pathogens responsible for dengue, yellow fever and several forms of encephalitis. Most common laboratory mice are sensitive to flavivirus infection. Resistance/sensitivity is conferred through the oligoA synthase Oas1b locus. In a comparison of multiple strains, CASA and CAST exhibit reduced numbers of retinal ganglion cells as compared to common laboratory strains and other wild-derived strains. In a 2015 study comparing CAST/Ei and the other Collaborative Cross inbred strains (A/J, C3H/HeJ, C57BL/6J, DBA/2J, 129S1/SvImJ, NOD/LtJ, NZO/HlLtJ, and WSB/EiJ), dorsal root ganglion neurons from CAST/Ei mice demonstrate a significantly improved ability to regenerate axons in an inhibitory environment as determined by an increase in number of neurons with neurites and longer axonal process per neuron under both naive and pre-injured conditions. In addition, as compared to neurons from C57BL/6 mice, CAST/Ei neurons exhibit more extensive axonal regeneration in the spinal cord and optic nerve following injury and show greater sprouting following ischemic stroke. Wild-derived mice are genetically distinct from common laboratory mice for a number of complex phenotypic characteristics and are valuable tools for genetic mapping, evolution and systematics research. RBO_relaxed.owl EFO:0007728 biolink:NamedThing FVB/NJ FVB/NJ was inbred for the Fv1b allele which confers sensitivity to the Friend leukemia virus B strain. Due to the prominent pronuclei in their fertilized eggs and the large litter size, FVB/NJ mice are commonly used for transgenic injection. Compared to many other inbred strains, FVB/NJ is highly susceptible to asthma-like airway responsiveness with significant generation of antigen-specific IgE. Despite having the H2q MHC haplotype, FVB/NJ are resistant to collagen-induced arthritis. This resistance stems from coding polymorphisms in Tcra-V11.1 and a genomic deletion of some Tcrb-V genes that includes Tcrb-V8.2. FVB/NJ have higher than average activity, anxiety, and basal body temperature, low stress-induced hyperthermia, and are homozygous for the Pde6brd1 allele, which results in early onset retinal degeneration. Although FVB/N typically do not develop spontaneous tumors, they are highly susceptible to chemically induced squamous cell carcinomas with a high rate of malignant conversion from papilloma to carcinoma. RBO_relaxed.owl EFO:0007729 biolink:NamedThing NZO/HlLtJ NZO mice of both sexes exhibit high birth weights and are significantly heavier at weaning age. Severe obesity (including both visceral and subcuatneous fat depots) develops even when mice are maintained on a standard diet containing 4.5% fat. Both males and females of the NZO/Hl substrain exhibit impaired glucose tolerance (IGT), but subsequent type 2 maturity onset (NIDDM) diabetes development is limited to males, with a phenotype penetrance of 50% or less. NZO/Hl mice also show anti-insulin receptor antibodies, a defect in leptin transport, and hypertension. The genetic lesion appears to be within the islets of Langerhans as transfer of pancreatic islets from normal mice returns body weights and blood glucose levels to within normal range. Ovarian granulosa cell tumors, lymphomas, duodenal, and lung tumors have also been noted to occur in NZO mice at an elevated frequency. F1 hybrids of NON/ShiLt and NZO/Hl provide a new model of obesity-induced diabetes. Male (NON/ShiLt x NZO/Hl)F1 hybrids are obese (BW = 53.5 g by 16 weeks) and almost all develop maturity onset NIDDM. F1 males on a 4% diet will develop hyperglycemia around 20 to 24 weeks of age; increasing the fat content of the diet accelerates diabetes onset to 16 to 20 weeks of age. (NZO/Hl x NON/ShiLt)F1 hybrids will develop diabetes slightly faster than their reciprocal cross due to the NZO maternal environment; however this cross is difficult to produce due to the inherently poor breeding performance of NZO/HlJ female mice. F1 females exhibit a weight gain similar to the NZO parent, and have impaired glucose tolerance but are resistant to diabetes development. Diabetes development can be accelerated to eight to 12 weeks by fostering onto an F1 dam. Reciprocal backcrosses to the parental strains and analysis of (NON/ShiLt x NZO/Hl)F2 mice has led to the identification of a number of complex diabetes-predisposing ("diabesity") QTLs. Dr. Leiter's research group at The Jackson Laboratory is currently developing a series of nine recombinant congenic strains (RCS) made by backcrossing the (NZO/Hl x NON/ShiLt)F1 for two generations onto the NON/ShiLt background before inbreeding (~12% NZO/Hl, 88% NON/ShiLt genomes). Preliminary analysis indicates that body weight gains of all RCS are higher than NON/ShiLt, but none are as obese as NZO/Hl; some of these RCS develop NIDDM while others are resistant. These new strains will be useful to further analyze diabesity QTLs and as new models for type 2 (NIDDM) diabetes. An additional benefit of the RCS is better breeding performance than NZO/Hl. RBO_relaxed.owl EFO:0007730 biolink:NamedThing PWK/PhJ PWK was derived from wild mice trapped near Prague, Czech Republic. PWK has a biochemical profile that is similar to the inbred strain PWD (also originating from the Czech Republic - Stock No. 004660) with the exception of the isoenzyme variant esterase 13 (Es13b). Wild-derived mice are genetically distinct from common laboratory mice for a number of complex phenotypic characteristics and are valuable tools for genetic mapping, evolution and systematics research. RBO_relaxed.owl EFO:0007731 biolink:NamedThing WSB/EiJ Watkins Star Line B (WSB) was derived from wild mice trapped in Eastern Shore, Maryland. WSB is characterized by a distinct and consistent white head blaze, variable ventral spotting and a slight coat dilution on the agouti background. The variation in pigment is the result of the spontaneous mutation blaze (Kitlblz).Wild-derived mice are genetically distinct from common laboratory mice for a number of complex phenotypic characteristics and are valuable tools for genetic mapping, evolution and systematics research. RBO_relaxed.owl EFO:0007733 biolink:NamedThing LP/J LP/J mice display a high susceptibility to audiogenic seizures. This strain is also reported to have a fairly high incidence of tumors that develop later in life, including mammary tumors, lymphoma, lung and soft-tissue sarcomas. LP/J mice are also homozygous for the spontaneous mutation piebald in the endothelin receptor type B gene (Ednrbs). The piebald spontaneous mutation is the result of a mutation in the endothelin receptor type B gene, Ednrb. Mice show irregular white spotting, the amount of which is greatly influenced by minor modifying genes. They also have dark eyes. The white areas of the coat are completely lacking in neural crest-derived melanocytes, and there is a reduction in the number of melanocytes in the choroid layer of the eye. RBO_relaxed.owl EFO:0009917 biolink:NamedThing ICR/HaJ ICR/HaJ is a mouse strain as described in Jackson Laboratory strain index. This inbred strain is derived from the outbred strain ICR. It may be useful in therapeutic drug testing and genetic analysis of carcinogen-induced colon cancer. RBO_relaxed.owl EFO:0010946 biolink:NamedThing C57BL/6JxCAST/EiJ A Mus musculus individual that is a substrain of C57BL/6J (mother) and CAST/EiJ (father). RBO_relaxed.owl EFO:0022419 biolink:NamedThing DBA Inbred Strain. RBO_relaxed.owl EFO:0022463 biolink:NamedThing CBA Strain family. RBO_relaxed.owl EFO:0004005 biolink:NamedThing inbred Mus musculus strain An inbred strain carrying one or more phenotypic mutations. For example, the mutant strain C3H/H3eSn-bc3J/J carries the bouncy 3 Jackson phenotypic mutation. RBO_relaxed.owl EFO:0005184 biolink:NamedThing DBA/2J Inbred Strain TJL Mating System: Sibling x Sibling (Female x Male) Species: laboratory mouse H2 Haplotype: d Generation: F219p (14-DEC-06) Appearance: dilute brown Related Genotype: a/a Tyrp1b/Tyrp1b Myo5ad/Myo5ad Important Note This strain is homozygous for Cdh23ahl, the age related hearing loss 1 mutation, which on this background results in progressive hearing loss that is already severe by 3 months of age. Strain Description DBA/2J is a widely used inbred strain that is valuable in a wide number of research areas including cardiovascular biology, neurobiology, and sensorineural research. RBO_relaxed.owl EFO:0007734 biolink:NamedThing SPRET/EiJ The wild-derived inbred strain SPRET/Ei is often used in crosses with common inbred strains to create highly polymorphic panels for genetic mapping. SPRET/Ei mice are resistant to high doses of tumor necrosis factor alpha (TNFa) (Staelens et al 2002). Mice from a C57BL/6 x SPRET/Ei F1 cross were protected from TNFa-induced arthritis and partially protected against induced allergic asthma (Staelens et al 2004). SPRET/Ei may be useful in understanding certain inflammatory diseases. RBO_relaxed.owl EFO:0007735 biolink:NamedThing CBA/J CBA/J inbred mice are widely used as a general purpose strain. CBA/J strain is the only CBA substrain that carries the Pde6brd1 mutation, which causes blindness by wean age. CBA/J mice are not histocompatible with the CBA/CaJ (Stock No. 000654) substrain (Green and Kaufer, 1965). The CBA/J inbred mouse strain is used to study granulomatous experimental autoimmune thyroiditis (G-EAT), are relatively resistant to diet-induced atherosclerosis (Paigen et al. 1990), and develop a mild hearing loss late in life, with most of the hearing loss occurring in the higher frequencies (Sweet et al. 1988). Renal tubulointerstitial lesions have been observed in this strain at a high frequency (Rudofsky 1978). Some CBA/J mice spontaneously develop exocrine pancreatic insufficiency syndrome (Eppig and Leiter 1977, Leiter et al. 1977). RBO_relaxed.owl EFO:0007839 biolink:NamedThing CAROLI/EiJ CAROLI was derived from wild mice trapped in Thailand and is from the species Mus caroli, which is distantly related to laboratory mice and does not breed with laboratory mice. These mice are characterized by black feet. This wild derived mouse strain is genetically distinct from common laboratory mice for a number of complex phenotypic characteristics and is a valuable tool for sequence comparison, evolution and systematics research. RBO_relaxed.owl BFO:0000050 biolink:NamedThing part of For continuants: C part_of C' if and only if: given any c that instantiates C at a time t, there is some c' such that c' instantiates C' at time t, and c *part_of* c' at t. For processes: P part_of P' if and only if: given any p that instantiates P at a time t, there is some p' such that p' instantiates P' at time t, and p *part_of* p' at t. (Here *part_of* is the instance-level part-relation.)|a core relation that holds between a part and its whole RBO_relaxed.owl RO:0002131 biolink:NamedThing overlaps x overlaps y if and only if there exists some z such that x has part z and z part of y|x overlaps y iff they have some part in common. RBO_relaxed.owl BFO:0000051 biolink:NamedThing has part a core relation that holds between a whole and its part RBO_relaxed.owl RO:0001901 biolink:NamedThing RBO_relaxed.owl OBO:valid_for_go_annotation_extension biolink:NamedThing RBO_relaxed.owl OBO:valid_for_go_gp2term biolink:NamedThing RBO_relaxed.owl OBO:valid_for_go_ontology biolink:NamedThing RBO_relaxed.owl OBO:valid_for_gocam biolink:NamedThing RBO_relaxed.owl http://ontologydesignpatterns.org/wiki/Community:Parts_and_Collections biolink:NamedThing RBO_relaxed.owl http://ontologydesignpatterns.org/wiki/Submissions:PartOf biolink:NamedThing RBO_relaxed.owl BFO:0000054 biolink:NamedThing realized in RBO_relaxed.owl BFO:0000055 biolink:NamedThing realizes RBO_relaxed.owl OBO:COB_0000087 biolink:NamedThing realizes RBO_relaxed.owl OBO:bfo.owl biolink:NamedThing RBO_relaxed.owl OBO:iao.owl biolink:NamedThing RBO_relaxed.owl BFO:0000057 biolink:NamedThing has participant RBO_relaxed.owl BFO:0000062 biolink:NamedThing preceded by x is preceded by y if and only if the time point at which y ends is before or equivalent to the time point at which x starts. Formally: x preceded by y iff ω(y) <= α(x), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point. RBO_relaxed.owl RO:0002086 biolink:NamedThing ends after RBO_relaxed.owl BFO:0000063 biolink:NamedThing precedes x precedes y if and only if the time point at which x ends is before or equivalent to the time point at which y starts. Formally: x precedes y iff ω(x) <= α(y), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point. RBO_relaxed.owl OBO:ro/subsets#ro-eco biolink:NamedThing RBO_relaxed.owl RO:0002222 biolink:NamedThing temporally related to RBO_relaxed.owl BFO:0000066 biolink:NamedThing occurs in b occurs_in c =def b is a process and c is a material entity or immaterial entity& there exists a spatiotemporal region r and b occupies_spatiotemporal_region r.& forall(t) if b exists_at t then c exists_at t & there exist spatial regions s and s’ where & b spatially_projects_onto s at t& c is occupies_spatial_region s’ at t& s is a proper_continuant_part_of s’ at t RBO_relaxed.owl BFO:0000067 biolink:NamedThing contains process [copied from inverse property 'occurs in'] b occurs_in c =def b is a process and c is a material entity or immaterial entity& there exists a spatiotemporal region r and b occupies_spatiotemporal_region r.& forall(t) if b exists_at t then c exists_at t & there exist spatial regions s and s’ where & b spatially_projects_onto s at t& c is occupies_spatial_region s’ at t& s is a proper_continuant_part_of s’ at t RBO_relaxed.owl BSPO:0000096 biolink:NamedThing anterior to x anterior to y iff x is further along the antero-posterior axis than y, towards the head. An antero-posterior axis is an axis that extends through an organism from head end to opposite end of body or tail. RBO_relaxed.owl BSPO:0000099 biolink:NamedThing posterior to x posterior to y iff x is further along the antero-posterior axis than y, towards the body/tail. An antero-posterior axis is an axis that extends through an organism from head end to opposite end of body or tail. RBO_relaxed.owl FBcv:0000039 biolink:NamedThing RBO_relaxed.owl OBO:FBql_00005863 biolink:NamedThing RBO_relaxed.owl BSPO:0000098 biolink:NamedThing dorsal to x dorsal to y iff x is further along the dorso-ventral axis than y, towards the back. A dorso-ventral axis is an axis that extends through an organism from back (e.g. spinal column) to front (e.g. belly). RBO_relaxed.owl BSPO:0000102 biolink:NamedThing ventral to x ventral to y iff x is further along the dorso-ventral axis than y, towards the front. A dorso-ventral axis is an axis that extends through an organism from back (e.g. spinal column) to front (e.g. belly). RBO_relaxed.owl FBcv:0000041 biolink:NamedThing RBO_relaxed.owl OBO:FBql_00005865 biolink:NamedThing RBO_relaxed.owl FBcv:0000045 biolink:NamedThing RBO_relaxed.owl OBO:FBql_00005864 biolink:NamedThing RBO_relaxed.owl FBcv:0000049 biolink:NamedThing RBO_relaxed.owl OBO:FBql_00005866 biolink:NamedThing RBO_relaxed.owl BSPO:0000107 biolink:NamedThing deep to Further away from the surface of the organism. Thus, the muscular layer is deep to the skin, but superficial to the intestines. RBO_relaxed.owl BSPO:0000108 biolink:NamedThing superficial to Near the outer surface of the organism. Thus, skin is superficial to the muscle layer. RBO_relaxed.owl BSPO:0000120 biolink:NamedThing in left side of X in left side of Y <=> if Y is subdivided into two left and right portions, X is part of the left portion. RBO_relaxed.owl BSPO:0000126 biolink:NamedThing in lateral side of X in lateral side of Y <=> if X is in left side of Y or X is in right side of Y. X is often, but not always a paired structure RBO_relaxed.owl BSPO:0000121 biolink:NamedThing in right side of X in right side of Y <=> if Y is subdivided into two left and right portions, X is part of the right portion. RBO_relaxed.owl BSPO:0000122 biolink:NamedThing in posterior side of X posterior side of Y <=> if Y is subdivided into two anterior and posterior portions, X is part of the posterior portion. RBO_relaxed.owl BSPO:0000123 biolink:NamedThing in anterior side of X anterior side of Y <=> if Y is subdivided into two anterior and posterior portions, X is part of the anterior portion. RBO_relaxed.owl BSPO:0000124 biolink:NamedThing in proximal side of x in proximal side of y <=> if y is subdivided into two proximal and distal portions, y is part of the proximal portion. RBO_relaxed.owl BSPO:0000125 biolink:NamedThing in distal side of x in distal side of y <=> if y is subdivided into two proximal and distal portions, y is part of the distal portion. RBO_relaxed.owl https://github.com/obophenotype/uberon/issues/2453 biolink:NamedThing RBO_relaxed.owl BSPO:0001106 biolink:NamedThing proximalmost part of X proximalmost part of Y <=> X is in proximal side of Y and X is adjacent to the proximal boundary of Y RBO_relaxed.owl BSPO:0001107 biolink:NamedThing immediately deep to x immediately deep to y iff x deep_to y and x is contiguous with y. RBO_relaxed.owl BSPO:0015014 biolink:NamedThing immediately superficial to x immediately superficial to y iff x superficial to y and x is contiguous with y. RBO_relaxed.owl BSPO:0001108 biolink:NamedThing distalmost part of X distalmost part of Y <=> X is in distal side of Y and X is adjacent to the distal boundary of Y RBO_relaxed.owl BSPO:0005001 biolink:NamedThing intersects midsagittal plane of X intersects median plane of iff X crosses the midine plane of Y. RBO_relaxed.owl RO:0002220 biolink:NamedThing adjacent to x adjacent to y if and only if x and y share a boundary. RBO_relaxed.owl BSPO:0015101 biolink:NamedThing in dorsal side of X dorsal side of Y <=> if Y is subdivided into two dorsal and ventral portions, X is part of the dorsal portion. RBO_relaxed.owl CL:4030045 biolink:NamedThing lacks_part RBO_relaxed.owl CL:4030046 biolink:NamedThing lacks_plasma_membrane_part RBO_relaxed.owl OBO:COB_0000078 biolink:NamedThing concretizes RBO_relaxed.owl RO:0000058 biolink:NamedThing is concretized as A relationship between a generically dependent continuant and a specifically dependent continuant, in which the generically dependent continuant depends on some independent continuant in virtue of the fact that the specifically dependent continuant also depends on that same independent continuant. A generically dependent continuant may be concretized as multiple specifically dependent continuants. RBO_relaxed.owl OBO:COB_0000081 biolink:NamedThing intended to realize RBO_relaxed.owl ENVO:01001307 biolink:NamedThing partially_surrounded_by x partially_surrounded_by y if and only if (1) x is adjacent to y and for the region r that is adjacent to x, r partially overlaps y (2) the shared boundary between x and y occupies a non-trivial proportion of the outermost boundary of x RBO_relaxed.owl ENVO:01003004 biolink:NamedThing derives from part of A relation between two distinct material entities, the new entity and the old entity, in which the new entity begins to exist through the separation or transformation of a part of the old entity, and the new entity inherits a significant portion of the matter belonging to that part of the old entity. RBO_relaxed.owl ENVO:02500016 biolink:NamedThing results in expansion of A process, p, results in the expansion of a material entity, m, if the spatial extent of m is increased as a result of participating in p. RBO_relaxed.owl ENVO:2000036 biolink:NamedThing generates A relation between a process and a disposition such that the existence of the disposition is caused by the execution of the process. RBO_relaxed.owl ORCID:0000-0002-6601-2165 biolink:NamedThing RBO_relaxed.owl GOREL:0002003 biolink:NamedThing results in distribution of RBO_relaxed.owl GOREL:0002004 biolink:NamedThing results in fission of RBO_relaxed.owl RO:0000057 biolink:NamedThing has participant Has_participant is a primitive instance-level relation between a process, a continuant, and a time at which the A continuant participates in some way in the process. The relation obtains, for example, when this particular process of oxygen exchange across this particular alveolar membrane has_participant this particular sample of hemoglobin at this particular time.|a relation between a process and a continuant, in which the continuant is somehow involved in the process RBO_relaxed.owl OBO:HANCESTRO_0301 biolink:NamedThing hasAncestryStatus RBO_relaxed.owl IAO:0000039 biolink:NamedThing has measurement unit label RBO_relaxed.owl IAO:0000136 biolink:NamedThing is about A (currently) primitive relation that relates an information artifact to an entity. RBO_relaxed.owl IAO:0000125 biolink:NamedThing pending final vetting All definitions, placement in the asserted IS_A hierarchy and required minimal metadata are complete. The class is awaiting a final review by someone other than the term editor. RBO_relaxed.owl IAO:0000221 biolink:NamedThing is quality measurement of m is a quality measurement of q at t. When q is a quality, there is a measurement process p that has specified output m, a measurement datum, that is about q RBO_relaxed.owl IAO:0000417 biolink:NamedThing is quality measured as inverse of the relation of is quality measurement of RBO_relaxed.owl IAO:0000120 biolink:NamedThing metadata complete Class has all its metadata, but is either not guaranteed to be in its final location in the asserted IS_A hierarchy or refers to another class that is not complete. RBO_relaxed.owl OBI:0000124 biolink:NamedThing is_supported_by_data The relation between a data item and a conclusion where the conclusion is the output of a data interpreting process and the data item is used as an input to that process RBO_relaxed.owl IAO:0000122 biolink:NamedThing ready for release Class has undergone final review, is ready for use, and will be included in the next release. Any class lacking "ready_for_release" should be considered likely to change place in hierarchy, have its definition refined, or be obsoleted in the next release. Those classes deemed "ready_for_release" will also derived from a chain of ancestor classes that are also "ready_for_release." RBO_relaxed.owl OBI:0000293 biolink:NamedThing has specified input The inverse property of is_specified_input_of RBO_relaxed.owl OBI:0000295 biolink:NamedThing is specified input of A relation between a planned process and a continuant participating in that process that is not created during the process. The presence of the continuant during the process is explicitly specified in the plan specification which the process realizes the concretization of. RBO_relaxed.owl OBO:obi.owl biolink:NamedThing RBO_relaxed.owl RO:0000056 biolink:NamedThing participates in Participates in is a primitive instance-level relation between a continuant and a process in which it participates. For example a scanner participates in a scanning process at some specific time.|a relation between a continuant and a process, in which the continuant is somehow involved in the process RBO_relaxed.owl OBI:0000299 biolink:NamedThing has specified output The inverse property of is_specified_output_of RBO_relaxed.owl OBI:0000312 biolink:NamedThing is specified output of A relation between a planned process and a continuant participating in that process. The presence of the continuant at the end of the process is explicitly specified in the objective specification which the process realizes the concretization of. RBO_relaxed.owl OBI:0000417 biolink:NamedThing achieves_planned_objective This relation obtains between a planned process and a objective specification when the criteria specified in the objective specification are met at the end of the planned process. RBO_relaxed.owl OBI:0000833 biolink:NamedThing objective_achieved_by This relation obtains between an objective specification and a planned process when the criteria specified in the objective specification are met at the end of the planned process. RBO_relaxed.owl OBI:0001938 biolink:NamedThing has value specification A relation between an information content entity and a value specification that specifies its value. RBO_relaxed.owl RO:0000052 biolink:NamedThing characteristic of a relation between a specifically dependent continuant (the characteristic) and any other entity (the bearer), in which the characteristic depends on the bearer for its existence.|a relation between a specifically dependent continuant (the dependent) and an independent continuant (the bearer), in which the dependent specifically depends on the bearer for its existence RBO_relaxed.owl RO:0002314 biolink:NamedThing characteristic of part of q characteristic of part of w if and only if there exists some p such that q inheres in p and p part of w.|q inheres in part of w if and only if there exists some p such that q inheres in p and p part of w. RBO_relaxed.owl RO:0000053 biolink:NamedThing bearer of Inverse of characteristic_of|a relation between an independent continuant (the bearer) and a specifically dependent continuant (the dependent), in which the dependent specifically depends on the bearer for its existence RBO_relaxed.owl OBO:ro.owl biolink:NamedThing RBO_relaxed.owl RO:0000059 biolink:NamedThing concretizes A relationship between a specifically dependent continuant and a generically dependent continuant, in which the generically dependent continuant depends on some independent continuant in virtue of the fact that the specifically dependent continuant also depends on that same independent continuant. Multiple specifically dependent continuants can concretize the same generically dependent continuant. RBO_relaxed.owl RO:0000079 biolink:NamedThing function of a relation between a function and an independent continuant (the bearer), in which the function specifically depends on the bearer for its existence RBO_relaxed.owl RO:0000085 biolink:NamedThing has function a relation between an independent continuant (the bearer) and a function, in which the function specifically depends on the bearer for its existence RBO_relaxed.owl RO:0000080 biolink:NamedThing quality of a relation between a quality and an independent continuant (the bearer), in which the quality specifically depends on the bearer for its existence RBO_relaxed.owl RO:0000086 biolink:NamedThing has quality a relation between an independent continuant (the bearer) and a quality, in which the quality specifically depends on the bearer for its existence RBO_relaxed.owl RO:0000081 biolink:NamedThing role of a relation between a role and an independent continuant (the bearer), in which the role specifically depends on the bearer for its existence RBO_relaxed.owl RO:0000087 biolink:NamedThing has role a relation between an independent continuant (the bearer) and a role, in which the role specifically depends on the bearer for its existence RBO_relaxed.owl RO:0000091 biolink:NamedThing has disposition a relation between an independent continuant (the bearer) and a disposition, in which the disposition specifically depends on the bearer for its existence RBO_relaxed.owl RO:0000092 biolink:NamedThing disposition of inverse of has disposition RBO_relaxed.owl RO:0002259 biolink:NamedThing RBO_relaxed.owl RO:0001000 biolink:NamedThing derives from a relation between two distinct material entities, the new entity and the old entity, in which the new entity begins to exist when the old entity ceases to exist, and the new entity inherits the significant portion of the matter of the old entity RBO_relaxed.owl RO:0001001 biolink:NamedThing derives into a relation between two distinct material entities, the old entity and the new entity, in which the new entity begins to exist when the old entity ceases to exist, and the new entity inherits the significant portion of the matter of the old entity RBO_relaxed.owl RO:0001015 biolink:NamedThing location of a relation between two independent continuants, the location and the target, in which the target is entirely within the location RBO_relaxed.owl RO:0001025 biolink:NamedThing located in a relation between two independent continuants, the target and the location, in which the target is entirely within the location RBO_relaxed.owl RO:0001018 biolink:NamedThing contained in RBO_relaxed.owl RO:0001019 biolink:NamedThing contains RBO_relaxed.owl RO:0002000 biolink:NamedThing 2D boundary of a relation between a 2D immaterial entity (the boundary) and a material entity, in which the boundary delimits the material entity RBO_relaxed.owl RO:0002002 biolink:NamedThing has 2D boundary a relation between a material entity and a 2D immaterial entity (the boundary), in which the boundary delimits the material entity RBO_relaxed.owl ORCID:0000-0002-7073-9172 biolink:NamedThing RBO_relaxed.owl RO:0002005 biolink:NamedThing innervated_by RBO_relaxed.owl RO:0002134 biolink:NamedThing innervates Relation between a 'neuron projection bundle' and a region in which one or more of its component neuron projections either synapses to targets or receives synaptic input. T innervates some R Expands_to: T has_fasciculating_neuron_projection that synapse_in some R. RBO_relaxed.owl RO:0002007 biolink:NamedThing bounding layer of X outer_layer_of Y iff: . X :continuant that bearer_of some PATO:laminar . X part_of Y . exists Z :surface . X has_boundary Z . Z boundary_of Y has_boundary: http://purl.obolibrary.org/obo/RO_0002002 boundary_of: http://purl.obolibrary.org/obo/RO_0002000 RBO_relaxed.owl RO:0002013 biolink:NamedThing has regulatory component activity A 'has regulatory component activity' B if A and B are GO molecular functions (GO_0003674), A has_component B and A is regulated by B. RBO_relaxed.owl RO:0002017 biolink:NamedThing has component activity RBO_relaxed.owl RO:0002334 biolink:NamedThing regulated by inverse of regulates RBO_relaxed.owl RO:0002014 biolink:NamedThing has negative regulatory component activity A relationship that holds between a GO molecular function and a component of that molecular function that negatively regulates the activity of the whole. More formally, A 'has regulatory component activity' B iff :A and B are GO molecular functions (GO_0003674), A has_component B and A is negatively regulated by B. RBO_relaxed.owl RO:0002335 biolink:NamedThing negatively regulated by inverse of negatively regulates RBO_relaxed.owl RO:0002015 biolink:NamedThing has positive regulatory component activity A relationship that holds between a GO molecular function and a component of that molecular function that positively regulates the activity of the whole. More formally, A 'has regulatory component activity' B iff :A and B are GO molecular functions (GO_0003674), A has_component B and A is positively regulated by B. RBO_relaxed.owl RO:0002336 biolink:NamedThing positively regulated by inverse of positively regulates RBO_relaxed.owl RO:0002018 biolink:NamedThing has component process w 'has process component' p if p and w are processes, w 'has part' p and w is such that it can be directly disassembled into into n parts p, p2, p3, ..., pn, where these parts are of similar type. RBO_relaxed.owl RO:0002180 biolink:NamedThing has component w 'has component' p if w 'has part' p and w is such that it can be directly disassembled into into n parts p, p2, p3, ..., pn, where these parts are of similar type. RBO_relaxed.owl RO:0002021 biolink:NamedThing occurs across A relationship between a process and a barrier, where the process occurs in a region spanning the barrier. For cellular processes the barrier is typically a membrane. Examples include transport across a membrane and membrane depolarization. RBO_relaxed.owl RO:0002479 biolink:NamedThing has part that occurs in p has part that occurs in c if and only if there exists some p1, such that p has_part p1, and p1 occurs in c. RBO_relaxed.owl RO:0002022 biolink:NamedThing directly regulated by RBO_relaxed.owl RO:0002578 biolink:NamedThing directly regulates Process(P1) directly regulates process(P2) iff: P1 regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding regulates the kinase activity (P2) of protein B then P1 directly regulates P2.|p directly regulates q iff p is immediately causally upstream of q and p regulates q. RBO_relaxed.owl RO:0002023 biolink:NamedThing directly negatively regulated by Process(P2) is directly negatively regulated by process(P1) iff: P1 negatively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding negatively regulates the kinase activity (P2) of protein B then P2 directly negatively regulated by P1. RBO_relaxed.owl RO:0002630 biolink:NamedThing directly negatively regulates p directly negatively regulates q iff p is immediately causally upstream of q, and p negatively regulates q. RBO_relaxed.owl RO:0002024 biolink:NamedThing directly positively regulated by Process(P2) is directly postively regulated by process(P1) iff: P1 positively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding positively regulates the kinase activity (P2) of protein B then P2 is directly postively regulated by P1. RBO_relaxed.owl RO:0002629 biolink:NamedThing directly positively regulates p directly positively regulates q iff p is immediately causally upstream of q, and p positively regulates q. RBO_relaxed.owl RO:0002025 biolink:NamedThing has effector activity A 'has effector activity' B if A and B are GO molecular functions (GO_0003674), A 'has component activity' B and B is the effector (output function) of B. Each compound function has only one effector activity. RBO_relaxed.owl RO:0002081 biolink:NamedThing before or simultaneous with RBO_relaxed.owl RO:0002082 biolink:NamedThing simultaneous with x simultaneous with y iff ω(x) = ω(y) and ω(α ) = ω(α), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point and '=' indicates the same instance in time. RBO_relaxed.owl RO:0002084 biolink:NamedThing during which ends RBO_relaxed.owl RO:0002093 biolink:NamedThing ends during RBO_relaxed.owl RO:0002087 biolink:NamedThing immediately preceded by RBO_relaxed.owl RO:0002090 biolink:NamedThing immediately precedes RBO_relaxed.owl RO:0002100 biolink:NamedThing has soma location Relation between a neuron and a material anatomical entity that its soma is part of. RBO_relaxed.owl RO:0002103 biolink:NamedThing synapsed by Relation between an anatomical structure (including cells) and a neuron that chemically synapses to it. RBO_relaxed.owl RO:0002485 biolink:NamedThing receives input from RBO_relaxed.owl RO:0002120 biolink:NamedThing synapsed to Relation between a neuron and an anatomical structure (including cells) that it chemically synapses to. RBO_relaxed.owl PMID:22402613 biolink:NamedThing RBO_relaxed.owl RO:0002104 biolink:NamedThing has plasma membrane part Holds between a cell c and a protein complex or protein p if and only if that cell has as part a plasma_membrane[GO:0005886], and that plasma membrane has p as part. RBO_relaxed.owl ORCID:0000-0001-9990-8331 biolink:NamedThing RBO_relaxed.owl ORCID:0000-0003-1617-8244 biolink:NamedThing RBO_relaxed.owl PMID:19243617 biolink:NamedThing RBO_relaxed.owl RO:0002486 biolink:NamedThing sends output to RBO_relaxed.owl RO:0002323 biolink:NamedThing mereotopologically related to A mereological relationship or a topological relationship RBO_relaxed.owl RO:0002150 biolink:NamedThing continuous with X continuous_with Y if and only if X and Y share a fiat boundary. RBO_relaxed.owl RO:0002160 biolink:NamedThing only in taxon x only in taxon y if and only if x is in taxon y, and there is no other organism z such that y!=z a and x is in taxon z. RBO_relaxed.owl RO:0002162 biolink:NamedThing in taxon x is in taxon y if an only if y is an organism, and the relationship between x and y is one of: part of (reflexive), developmentally preceded by, derives from, secreted by, expressed. RBO_relaxed.owl PMID:17921072 biolink:NamedThing RBO_relaxed.owl PMID:20973947 biolink:NamedThing RBO_relaxed.owl https://github.com/obophenotype/uberon/wiki/Taxon-constraints biolink:NamedThing RBO_relaxed.owl RO:0002320 biolink:NamedThing evolutionarily related to A relationship that holds via some environmental process RBO_relaxed.owl ORCID:0000-0001-9227-417X biolink:NamedThing RBO_relaxed.owl RO:0002163 biolink:NamedThing spatially disjoint from A is spatially_disjoint_from B if and only if they have no parts in common RBO_relaxed.owl PMID:22293552 biolink:NamedThing RBO_relaxed.owl RO:0002170 biolink:NamedThing connected to a is connected to b if and only if a and b are discrete structure, and there exists some connecting structure c, such that c connects a and b RBO_relaxed.owl RO:0002176 biolink:NamedThing connects c connects a if and only if there exist some b such that a and b are similar parts of the same system, and c connects b, specifically, c connects a with b. When one structure connects two others it unites some aspect of the function or role they play within the system. RBO_relaxed.owl RO:0002177 biolink:NamedThing attached to part of a is attached to part of b if a is attached to b, or a is attached to some p, where p is part of b. RBO_relaxed.owl RO:0002567 biolink:NamedThing biomechanically related to A relation that holds between elements of a musculoskeletal system or its analogs. RBO_relaxed.owl RO:0002178 biolink:NamedThing supplies Relation between an arterial structure and another structure, where the arterial structure acts as a conduit channeling fluid, substance or energy. RBO_relaxed.owl PMID:20064205 biolink:NamedThing RBO_relaxed.owl RO:0002179 biolink:NamedThing drains Relation between an collecting structure and another structure, where the collecting structure acts as a conduit channeling fluid, substance or energy away from the other structure. RBO_relaxed.owl http://ontologydesignpatterns.org/wiki/Submissions:Componency biolink:NamedThing RBO_relaxed.owl RO:0002202 biolink:NamedThing develops from x develops from y if and only if either (a) x directly develops from y or (b) there exists some z such that x directly develops from z and z develops from y RBO_relaxed.owl RO:0002254 biolink:NamedThing has developmental contribution from x has developmental contribution from y iff x has some part z such that z develops from y RBO_relaxed.owl RO:0002258 biolink:NamedThing developmentally preceded by Candidate definition: x developmentally related to y if and only if there exists some developmental process (GO:0032502) p such that x and y both participates in p, and x is the output of p and y is the input of p RBO_relaxed.owl RO:0002203 biolink:NamedThing develops into inverse of develops from RBO_relaxed.owl ORCID:0000-0001-9114-8737 biolink:NamedThing RBO_relaxed.owl ORCID:0000-0003-1980-3228 biolink:NamedThing RBO_relaxed.owl RO:0002286 biolink:NamedThing developmentally succeeded by Inverse of developmentally preceded by RBO_relaxed.owl RO:0002387 biolink:NamedThing has potential to develop into x has the potential to develop into y iff x develops into y or if x is capable of developing into y RBO_relaxed.owl RO:0002388 biolink:NamedThing has potential to directly develop into x has potential to directly develop into y iff x directly develops into y or x is capable of directly developing into y RBO_relaxed.owl RO:0002207 biolink:NamedThing directly develops from Candidate definition: x directly_develops from y if and only if there exists some developmental process (GO:0032502) p such that x and y both participate in p, and x is the output of p and y is the input of p, and a substantial portion of the matter of x comes from y, and the start of x is coincident with or after the end of y. RBO_relaxed.owl RO:0002210 biolink:NamedThing directly develops into inverse of directly develops from RBO_relaxed.owl RO:0002211 biolink:NamedThing regulates p regulates q iff p is causally upstream of q, the execution of p is not constant and varies according to specific conditions, and p influences the rate or magnitude of execution of q due to an effect either on some enabler of q or some enabler of a part of q.|process(P1) regulates process(P2) iff: P1 results in the initiation or termination of P2 OR affects the frequency of its initiation or termination OR affects the magnitude or rate of output of P2. RBO_relaxed.owl RO:0002411 biolink:NamedThing causally upstream of p is causally upstream of q if and only if p precedes q and p and q are linked in a causal chain|p is causally upstream of q iff p is causally related to q, the end of p precedes the end of q, and p is not an occurrent part of q. RBO_relaxed.owl ORCID:0000-0001-7476-6306 biolink:NamedThing RBO_relaxed.owl ORCID:0000-0002-3837-8864 biolink:NamedThing RBO_relaxed.owl OBO:ro/docs/causal-relations biolink:NamedThing RBO_relaxed.owl RO:0002212 biolink:NamedThing negatively regulates Process(P1) negatively regulates process(P2) iff: P1 terminates P2, or P1 descreases the the frequency of initiation of P2 or the magnitude or rate of output of P2.|p negatively regulates q iff p regulates q, and p decreases the rate or magnitude of execution of q. RBO_relaxed.owl RO:0002305 biolink:NamedThing causally upstream of, negative effect p is causally upstream of, negative effect q iff p is casually upstream of q, and the execution of p decreases the execution of q. RBO_relaxed.owl RO:0002213 biolink:NamedThing positively regulates Process(P1) postively regulates process(P2) iff: P1 initiates P2, or P1 increases the the frequency of initiation of P2 or the magnitude or rate of output of P2.|p positively regulates q iff p regulates q, and p increases the rate or magnitude of execution of q. RBO_relaxed.owl RO:0002304 biolink:NamedThing causally upstream of, positive effect p is causally upstream of, positive effect q iff p is casually upstream of q, and the execution of p is required for the execution of q. RBO_relaxed.owl RO:0002215 biolink:NamedThing capable of A relation between a material entity (such as a cell) and a process, in which the material entity has the ability to carry out the process. RBO_relaxed.owl RO:0002216 biolink:NamedThing capable of part of c stands in this relationship to p if and only if there exists some p' such that c is capable_of p', and p' is part_of p. RBO_relaxed.owl PMID:20123131 biolink:NamedThing RBO_relaxed.owl PMID:21208450 biolink:NamedThing RBO_relaxed.owl RO:0002328 biolink:NamedThing functionally related to A grouping relationship for any relationship directly involving a function, or that holds because of a function of one of the related entities. RBO_relaxed.owl RO:0002500 biolink:NamedThing causal agent in process A relationship between a material entity and a process where the material entity has some causal role that influences the process RBO_relaxed.owl OBO:ro/docs/reflexivity/ biolink:NamedThing RBO_relaxed.owl https://github.com/oborel/obo-relations/wiki/ROGuide#defining-property-chains-involving-reflexivity biolink:NamedThing RBO_relaxed.owl RO:0002219 biolink:NamedThing surrounded by x surrounded_by y if and only if (1) x is adjacent to y and for every region r that is adjacent to x, r overlaps y (2) the shared boundary between x and y occupies the majority of the outermost boundary of x RBO_relaxed.owl RO:0002221 biolink:NamedThing surrounds inverse of surrounded by RBO_relaxed.owl https://en.wikipedia.org/wiki/Allen%27s_interval_algebra biolink:NamedThing RBO_relaxed.owl RO:0002223 biolink:NamedThing starts inverse of starts with RBO_relaxed.owl RO:0002224 biolink:NamedThing starts with x starts with y if and only if x has part y and the time point at which x starts is equivalent to the time point at which y starts. Formally: α(y) = α(x) ∧ ω(y) < ω(x), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point. RBO_relaxed.owl RO:0002225 biolink:NamedThing develops from part of x develops from part of y if and only if there exists some z such that x develops from z and z is part of y RBO_relaxed.owl RO:0002226 biolink:NamedThing develops in x develops_in y if x is located in y whilst x is developing RBO_relaxed.owl RO:0002229 biolink:NamedThing ends inverse of ends with RBO_relaxed.owl RO:0002230 biolink:NamedThing ends with x ends with y if and only if x has part y and the time point at which x ends is equivalent to the time point at which y ends. Formally: α(y) > α(x) ∧ ω(y) = ω(x), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point. RBO_relaxed.owl RO:0002231 biolink:NamedThing has start location x 'has starts location' y if and only if there exists some process z such that x 'starts with' z and z 'occurs in' y RBO_relaxed.owl RO:0002232 biolink:NamedThing has end location x 'has end location' y if and only if there exists some process z such that x 'ends with' z and z 'occurs in' y RBO_relaxed.owl RO:0002233 biolink:NamedThing has input p has input c iff: p is a process, c is a material entity, c is a participant in p, c is present at the start of p, and the state of c is modified during p. RBO_relaxed.owl RO:0002352 biolink:NamedThing input of inverse of has input RBO_relaxed.owl RO:0002234 biolink:NamedThing has output p has output c iff c is a participant in p, c is present at the end of p, and c is not present in the same state at the beginning of p. RBO_relaxed.owl RO:0002353 biolink:NamedThing output of inverse of has output RBO_relaxed.owl RO:0002252 biolink:NamedThing connecting branch of b connecting-branch-of s iff b is connected to s, and there exists some tree-like structure t such that the mereological sum of b plus s is either the same as t or a branching-part-of t. RBO_relaxed.owl RO:0002375 biolink:NamedThing in branching relationship with A relationship that holds between two material entities in a system of connected structures, where the branching relationship holds based on properties of the connecting network. RBO_relaxed.owl RO:0002253 biolink:NamedThing has connecting branch inverse of connecting branch of RBO_relaxed.owl https://github.com/obophenotype/uberon/issues/2212 biolink:NamedThing RBO_relaxed.owl RO:0002255 biolink:NamedThing developmentally contributes to inverse of has developmental contribution from RBO_relaxed.owl RO:0002385 biolink:NamedThing has potential to developmentally contribute to x has potential to developmentrally contribute to y iff x developmentally contributes to y or x is capable of developmentally contributing to y RBO_relaxed.owl RO:0002256 biolink:NamedThing developmentally induced by t1 induced_by t2 if there is a process of developmental induction (GO:0031128) with t1 and t2 as interacting participants. t2 causes t1 to change its fate from a precursor material anatomical entity type T to T', where T' develops_from T RBO_relaxed.owl RO:0002257 biolink:NamedThing developmentally induces Inverse of developmentally induced by RBO_relaxed.owl RO:0002386 biolink:NamedThing has potential to developmentally induce x has potential to developmentally induce y iff x developmentally induces y or x is capable of developmentally inducing y RBO_relaxed.owl RO:0002324 biolink:NamedThing developmentally related to A relationship that holds between entities participating in some developmental process (GO:0032502) RBO_relaxed.owl RO:0002263 biolink:NamedThing acts upstream of c acts upstream of p if and only if c enables some f that is involved in p' and p' occurs chronologically before p, is not part of p, and affects the execution of p. c is a material entity and f, p, p' are processes. RBO_relaxed.owl RO:0002264 biolink:NamedThing acts upstream of or within c acts upstream of or within p if c is enables f, and f is causally upstream of or within p. c is a material entity and p is an process. RBO_relaxed.owl http://wiki.geneontology.org/index.php/Acts_upstream_of biolink:NamedThing RBO_relaxed.owl http://wiki.geneontology.org/index.php/Acts_upstream_of_or_within biolink:NamedThing RBO_relaxed.owl RO:0002285 biolink:NamedThing developmentally replaces x developmentally replaces y if and only if there is some developmental process that causes x to move or to cease to exist, and for the site that was occupied by x to become occupied by y, where y either comes into existence in this site or moves to this site from somewhere else RBO_relaxed.owl RO:0002384 biolink:NamedThing has developmental potential involving x has developmental potential involving y iff x is capable of a developmental process with output y. y may be the successor of x, or may be a different structure in the vicinity (as for example in the case of developmental induction). RBO_relaxed.owl RO:0002287 biolink:NamedThing part of developmental precursor of RBO_relaxed.owl RO:0002295 biolink:NamedThing results in developmental progression of p results in the developmental progression of s iff p is a developmental process and s is an anatomical entity and p causes s to undergo a change in state at some point along its natural developmental cycle (this cycle starts with its formation, through the mature structure, and ends with its loss). RBO_relaxed.owl http://wiki.geneontology.org/index.php/Ontology_extensions biolink:NamedThing RBO_relaxed.owl RO:0002296 biolink:NamedThing results in development of p 'results in development of' c if and only if p is a developmental process and p results in the state of c changing from its initial state as a primordium or anlage through its mature state and to its final state. RBO_relaxed.owl RO:0040036 biolink:NamedThing results in changes to anatomical or cellular structure p has anatomical participant c iff p has participant c, and c is an anatomical entity RBO_relaxed.owl RO:0002297 biolink:NamedThing results in formation of RBO_relaxed.owl RO:0002354 biolink:NamedThing formed as result of RBO_relaxed.owl RO:0002298 biolink:NamedThing results in morphogenesis of The relationship that links an entity with the process that results in the formation and shaping of that entity over time from an immature to a mature state. RBO_relaxed.owl RO:0002299 biolink:NamedThing results in maturation of The relationship that links an entity with a process that results in the progression of the entity over time that is independent of changes in it's shape and results in an end point state of that entity. RBO_relaxed.owl RO:0002303 biolink:NamedThing has habitat x 'has habitat' y if and only if: x is an organism, y is a habitat, and y can sustain and allow the growth of a population of xs. RBO_relaxed.owl RO:0002321 biolink:NamedThing ecologically related to A relationship that is mediated in some way by the environment or environmental feature (ENVO:00002297) RBO_relaxed.owl IAO:0000428 biolink:NamedThing requires discussion A term that is metadata complete, has been reviewed, and problems have been identified that require discussion before release. Such a term requires editor note(s) to identify the outstanding issues. RBO_relaxed.owl RO:0004047 biolink:NamedThing causally upstream of or within, positive effect RBO_relaxed.owl https://wiki.geneontology.org/Causally_upstream_of,_positive_effect biolink:NamedThing RBO_relaxed.owl RO:0004046 biolink:NamedThing causally upstream of or within, negative effect RBO_relaxed.owl https://wiki.geneontology.org/Causally_upstream_of,_negative_effect biolink:NamedThing RBO_relaxed.owl RO:0002502 biolink:NamedThing depends on RBO_relaxed.owl RO:0002315 biolink:NamedThing results in acquisition of features of The relationship that links a specified entity with the process that results in an unspecified entity acquiring the features and characteristics of the specified entity RBO_relaxed.owl RO:0002327 biolink:NamedThing enables c enables p iff c is capable of p and c acts to execute p. RBO_relaxed.owl RO:0002333 biolink:NamedThing enabled by inverse of enables RBO_relaxed.owl RO:0002329 biolink:NamedThing part of structure that is capable of this relation holds between c and p when c is part of some c', and c' is capable of p. RBO_relaxed.owl RO:0002331 biolink:NamedThing involved in c involved_in p if and only if c enables some process p', and p' is part of p RBO_relaxed.owl RO:0002431 biolink:NamedThing involved in or involved in regulation of c involved in or regulates p if and only if either (i) c is involved in p or (ii) c is involved in regulation of p RBO_relaxed.owl http://wiki.geneontology.org/index.php/Involved_in biolink:NamedThing RBO_relaxed.owl RO:0002427 biolink:NamedThing causally downstream of or within inverse of causally upstream of or within RBO_relaxed.owl RO:0002337 biolink:NamedThing related via localization to A relationship that holds via some process of localization RBO_relaxed.owl RO:0002338 biolink:NamedThing has target start location This relationship holds between p and l when p is a transport or localization process in which the outcome is to move some cargo c from some initial location l to some destination. RBO_relaxed.owl RO:0002344 biolink:NamedThing results in transport to from or in RBO_relaxed.owl RO:0002339 biolink:NamedThing has target end location This relationship holds between p and l when p is a transport or localization process in which the outcome is to move some cargo c from a an initial location to some destination l. RBO_relaxed.owl RO:0002341 biolink:NamedThing results in transport along Holds between p and l when p is a transportation or localization process and the outcome of this process is to move c from one location to another, and the route taken by c follows a path that is aligned_with l RBO_relaxed.owl RO:0002342 biolink:NamedThing results in transport across Holds between p and m when p is a transportation or localization process and the outcome of this process is to move c from one location to another, and the route taken by c follows a path that crosses m. RBO_relaxed.owl RO:0002343 biolink:NamedThing results in growth of RBO_relaxed.owl RO:0002350 biolink:NamedThing member of is member of is a mereological relation between a item and a collection. RBO_relaxed.owl RO:0002351 biolink:NamedThing has member has member is a mereological relation between a collection and an item. RBO_relaxed.owl RO:0002371 biolink:NamedThing attached to a is attached to b if and only if a and b are discrete objects or object parts, and there are physical connections between a and b such that a force pulling a will move b, or a force pulling b will move a RBO_relaxed.owl RO:0002372 biolink:NamedThing has muscle origin m has_muscle_origin s iff m is attached_to s, and it is the case that when m contracts, s does not move. The site of the origin tends to be more proximal and have greater mass than what the other end attaches to. RBO_relaxed.owl http://dbpedia.org/property/origin biolink:NamedThing RBO_relaxed.owl RO:0002373 biolink:NamedThing has muscle insertion m has_muscle_insertion s iff m is attaches_to s, and it is the case that when m contracts, s moves. Insertions are usually connections of muscle via tendon to bone. RBO_relaxed.owl http://dbpedia.org/property/insertion biolink:NamedThing RBO_relaxed.owl OBO:ro/docs/branching_part_of.png biolink:NamedThing RBO_relaxed.owl RO:0002376 biolink:NamedThing tributary of x tributary_of y if and only if x a channel for the flow of a substance into y, where y is larger than x. If x and y are hydrographic features, then y is the main stem of a river, or a lake or bay, but not the sea or ocean. If x and y are anatomical, then y is a vein. RBO_relaxed.owl http://dbpedia.org/ontology/drainsTo biolink:NamedThing RBO_relaxed.owl RO:0002379 biolink:NamedThing spatially coextensive with x spatially_coextensive_with y if and inly if x and y have the same location RBO_relaxed.owl RO:0002380 biolink:NamedThing branching part of x is a branching part of y if and only if x is part of y and x is connected directly or indirectly to the main stem of y RBO_relaxed.owl RO:0002569 biolink:NamedThing has branching part inverse of branching part of RBO_relaxed.owl RO:0002404 biolink:NamedThing causally downstream of inverse of upstream of RBO_relaxed.owl RO:0002405 biolink:NamedThing immediately causally downstream of RBO_relaxed.owl RO:0002412 biolink:NamedThing immediately causally upstream of p is immediately causally upstream of q iff both (a) p immediately precedes q and (b) p is causally upstream of q. In addition, the output of p must be an input of q.|p is immediately causally upstream of q iff p is causally upstream of q, and the end of p is coincident with the beginning of q. RBO_relaxed.owl RO:0002407 biolink:NamedThing indirectly positively regulates p indirectly positively regulates q iff p is indirectly causally upstream of q and p positively regulates q. RBO_relaxed.owl RO:0012012 biolink:NamedThing indirectly regulates p indirectly regulates q iff p is indirectly causally upstream of q and p regulates q. RBO_relaxed.owl RO:0002409 biolink:NamedThing indirectly negatively regulates p indirectly negatively regulates q iff p is indirectly causally upstream of q and p negatively regulates q. RBO_relaxed.owl RO:0002410 biolink:NamedThing causally related to This relation groups causal relations between material entities and causal relations between processes|relation that links two events, processes, states, or objects such that one event, process, state, or object (a cause) contributes to the production of another event, process, state, or object (an effect) where the cause is partly or wholly responsible for the effect, and the effect is partly or wholly dependent on the cause. RBO_relaxed.owl RO:0002418 biolink:NamedThing causally upstream of or within p 'causally upstream or within' q iff (1) the end of p is before the end of q and (2) the execution of p exerts some causal influence over the outputs of q; i.e. if p was abolished or the outputs of p were to be modified, this would necessarily affect q.|p is 'causally upstream or within' q iff p is causally related to q, and the end of p precedes, or is coincident with, the end of q. RBO_relaxed.owl RO:0002501 biolink:NamedThing causal relation between processes p is causally related to q if and only if p or any part of p and q or any part of q are linked by a chain of events where each event pair is one of direct activation or direct inhibition. p may be upstream, downstream, part of or a container of q.|p is causally related to q if and only if p or any part of p and q or any part of q are linked by a chain of events where each event pair is one where the execution of p influences the execution of q. p may be upstream, downstream, part of, or a container of q. RBO_relaxed.owl RO:0002428 biolink:NamedThing involved in regulation of c involved in regulation of p if c is involved in some p' and p' regulates some p RBO_relaxed.owl RO:0002429 biolink:NamedThing involved in positive regulation of c involved in regulation of p if c is involved in some p' and p' positively regulates some p RBO_relaxed.owl RO:0002430 biolink:NamedThing involved in negative regulation of c involved in regulation of p if c is involved in some p' and p' negatively regulates some p RBO_relaxed.owl RO:0002432 biolink:NamedThing is active in c executes activity in d if and only if c enables p and p occurs_in d. Assuming no action at a distance by gene products, if a gene product enables (is capable of) a process that occurs in some structure, it must have at least some part in that structure. RBO_relaxed.owl RO:0002433 biolink:NamedThing contributes to morphology of p contributes to morphology of w if and only if a change in the morphology of p entails a change in the morphology of w. Examples: every skull contributes to morphology of the head which it is a part of. Counter-example: nuclei do not generally contribute to the morphology of the cell they are part of, as they are buffered by cytoplasm. RBO_relaxed.owl RO:0002434 biolink:NamedThing interacts with A relationship that holds between two entities in which the processes executed by the two entities are causally connected. RBO_relaxed.owl RO:0002436 biolink:NamedThing molecularly interacts with An interaction relationship in which the two partners are molecular entities that directly physically interact with each other for example via a stable binding interaction or a brief interaction during which one modifies the other. RBO_relaxed.owl ECO:0000353 biolink:NamedThing RBO_relaxed.owl RO:0002447 biolink:NamedThing phosphorylates RBO_relaxed.owl RO:0002448 biolink:NamedThing directly regulates activity of The entity A, immediately upstream of the entity B, has an activity that regulates an activity performed by B. For example, A and B may be gene products and binding of B by A regulates the kinase activity of B. A and B can be physically interacting but not necessarily. Immediately upstream means there are no intermediate entity between A and B. RBO_relaxed.owl RO:0011002 biolink:NamedThing regulates activity of The entity A has an activity that regulates an activity of the entity B. For example, A and B are gene products where the catalytic activity of A regulates the kinase activity of B. RBO_relaxed.owl ORCID:0000-0003-4639-4431 biolink:NamedThing RBO_relaxed.owl RO:0002449 biolink:NamedThing directly negatively regulates activity of The entity A, immediately upstream of the entity B, has an activity that negatively regulates an activity performed by B. For example, A and B may be gene products and binding of B by A negatively regulates the kinase activity of B. RBO_relaxed.owl RO:0002450 biolink:NamedThing directly positively regulates activity of The entity A, immediately upstream of the entity B, has an activity that positively regulates an activity performed by B. For example, A and B may be gene products and binding of B by A positively regulates the kinase activity of B. RBO_relaxed.owl RO:0002464 biolink:NamedThing helper property (not for use in curation) RBO_relaxed.owl RO:0002473 biolink:NamedThing composed primarily of x composed_primarily_of y if and only if more than half of the mass of x is made from y or units of the same type as y. RBO_relaxed.owl RO:0002481 biolink:NamedThing is kinase activity RBO_relaxed.owl RO:0002564 biolink:NamedThing molecular interaction relation helper property RBO_relaxed.owl RO:0002487 biolink:NamedThing relation between physical entity and a process or stage RBO_relaxed.owl RO:0002488 biolink:NamedThing existence starts during x existence starts during y if and only if the time point at which x starts is after or equivalent to the time point at which y starts and before or equivalent to the time point at which y ends. Formally: x existence starts during y iff α(x) >= α(y) & α(x) <= ω(y). RBO_relaxed.owl RO:0002490 biolink:NamedThing existence overlaps x existence overlaps y if and only if either (a) the start of x is part of y or (b) the end of x is part of y. Formally: x existence starts and ends during y iff (α(x) >= α(y) & α(x) <= ω(y)) OR (ω(x) <= ω(y) & ω(x) >= α(y)) RBO_relaxed.owl RO:0002496 biolink:NamedThing existence starts during or after x existence starts during or after y if and only if the time point at which x starts is after or equivalent to the time point at which y starts. Formally: x existence starts during or after y iff α (x) >= α (y). RBO_relaxed.owl RO:0002489 biolink:NamedThing existence starts with x starts ends with y if and only if the time point at which x starts is equivalent to the time point at which y starts. Formally: x existence starts with y iff α(x) = α(y). RBO_relaxed.owl RO:0002491 biolink:NamedThing existence starts and ends during x exists during y if and only if: 1) the time point at which x begins to exist is after or equal to the time point at which y begins and 2) the time point at which x ceases to exist is before or equal to the point at which y ends. Formally: x existence starts and ends during y iff α(x) >= α(y) & α(x) <= ω(y) & ω(x) <= ω(y) & ω(x) >= α(y) RBO_relaxed.owl RO:0002492 biolink:NamedThing existence ends during Relation between continuant c and occurrent s, such that every instance of c ceases to exist during some s, if it does not die prematurely.|x existence ends during y if and only if the time point at which x ends is before or equivalent to the time point at which y ends and after or equivalent to the point at which y starts. Formally: x existence ends during y iff ω(x) <= ω(y) and ω(x) >= α(y). RBO_relaxed.owl RO:0002497 biolink:NamedThing existence ends during or before x existence ends during or before y if and only if the time point at which x ends is before or equivalent to the time point at which y ends. RBO_relaxed.owl RO:0002493 biolink:NamedThing existence ends with x existence ends with y if and only if the time point at which x ends is equivalent to the time point at which y ends. Formally: x existence ends with y iff ω(x) = ω(y). RBO_relaxed.owl RO:0002494 biolink:NamedThing transformation of x transformation of y if x is the immediate transformation of y, or is linked to y through a chain of transformation relationships RBO_relaxed.owl RO:0002495 biolink:NamedThing immediate transformation of x immediate transformation of y iff x immediately succeeds y temporally at a time boundary t, and all of the matter present in x at t is present in y at t, and all the matter in y at t is present in x at t RBO_relaxed.owl RO:0002595 biolink:NamedThing causal relation between material entity and a process A relationship that holds between a material entity and a process in which causality is involved, with either the material entity or some part of the material entity exerting some influence over the process, or the process influencing some aspect of the material entity. RBO_relaxed.owl RO:0002608 biolink:NamedThing process has causal agent Inverse of 'causal agent in process' RBO_relaxed.owl BFO:0000169 biolink:NamedThing RBO_relaxed.owl RO:0002506 biolink:NamedThing causal relation between entities RBO_relaxed.owl RO:0002509 biolink:NamedThing determined by part of s 'determined by part of' w if and only if there exists some f such that (1) s 'determined by' f and (2) f part_of w, or f=w. RBO_relaxed.owl RO:0002551 biolink:NamedThing has skeleton A relation between a segment or subdivision of an organism and the maximal subdivision of material entities that provides structural support for that segment or subdivision. RBO_relaxed.owl RO:0002576 biolink:NamedThing skeleton of inverse of has skeleton RBO_relaxed.owl RO:0002559 biolink:NamedThing causally influenced by RBO_relaxed.owl RO:0002566 biolink:NamedThing causally influences The entity or characteristic A is causally upstream of the entity or characteristic B, A having an effect on B. An entity corresponds to any biological type of entity as long as a mass is measurable. A characteristic corresponds to a particular specificity of an entity (e.g., phenotype, shape, size). RBO_relaxed.owl RO:0002563 biolink:NamedThing interaction relation helper property RBO_relaxed.owl http://ontologydesignpatterns.org/wiki/Submissions:N-Ary_Relation_Pattern_%28OWL_2%29 biolink:NamedThing RBO_relaxed.owl RO:0002568 biolink:NamedThing has muscle antagonist m1 has_muscle_antagonist m2 iff m1 has_muscle_insertion s, m2 has_muscle_insection s, m1 acts in opposition to m2, and m2 is responsible for returning the structure to its initial position. RBO_relaxed.owl RO:0002570 biolink:NamedThing conduit for x is a conduit for y iff y overlaps through the lumen_of of x, and y has parts on either side of the lumen of x. RBO_relaxed.owl RO:0002571 biolink:NamedThing lumen of x lumen_of y iff x is the space or substance that is part of y and does not cross any of the inner membranes or boundaries of y that is maximal with respect to the volume of the convex hull. RBO_relaxed.owl RO:0002572 biolink:NamedThing luminal space of s is luminal space of x iff s is lumen_of x and s is an immaterial entity RBO_relaxed.owl RO:0002584 biolink:NamedThing has part structure that is capable of s 'has part structure that is capable of' p if and only if there exists some part x such that s 'has part' x and x 'capable of' p RBO_relaxed.owl RO:0002586 biolink:NamedThing results in breakdown of p results in breakdown of c if and only if the execution of p leads to c no longer being present at the end of p RBO_relaxed.owl RO:0002588 biolink:NamedThing results in assembly of RBO_relaxed.owl RO:0002592 biolink:NamedThing results in organization of p results in organization of c iff p results in the assembly, arrangement of constituent parts, or disassembly of c RBO_relaxed.owl RO:0002590 biolink:NamedThing results in disassembly of RBO_relaxed.owl RO:0002596 biolink:NamedThing capable of regulating Holds between c and p if and only if c is capable of some activity a, and a regulates p. RBO_relaxed.owl RO:0002597 biolink:NamedThing capable of negatively regulating Holds between c and p if and only if c is capable of some activity a, and a negatively regulates p. RBO_relaxed.owl RO:0002598 biolink:NamedThing capable of positively regulating Holds between c and p if and only if c is capable of some activity a, and a positively regulates p. RBO_relaxed.owl RO:0003000 biolink:NamedThing produces a produces b if some process that occurs_in a has_output b, where a and b are material entities. Examples: hybridoma cell line produces monoclonal antibody reagent; chondroblast produces avascular GAG-rich matrix. RBO_relaxed.owl RO:0003001 biolink:NamedThing produced by a produced_by b iff some process that occurs_in b has_output a. RBO_relaxed.owl RO:0004007 biolink:NamedThing has primary input or output p 'has primary input ot output' c iff either (a) p 'has primary input' c or (b) p 'has primary output' c. RBO_relaxed.owl RO:0004008 biolink:NamedThing has primary output p has primary output c if (a) p has output c and (b) the goal of process is to modify, produce, or transform c. RBO_relaxed.owl RO:0004009 biolink:NamedThing has primary input p has primary input c if (a) p has input c and (b) the goal of process is to modify, consume, or transform c. RBO_relaxed.owl RO:0004028 biolink:NamedThing realized in response to stimulus A relationship between a realizable entity R (e.g. function or disposition) and a material entity M where R is realized in response to a process that has an input stimulus of M. RBO_relaxed.owl RO:0004031 biolink:NamedThing enables subfunction Holds between an entity and an process P where the entity enables some larger compound process, and that larger process has-part P. RBO_relaxed.owl RO:0004032 biolink:NamedThing acts upstream of or within, positive effect RBO_relaxed.owl http://wiki.geneontology.org/index.php/Acts_upstream_of_or_within,_positive_effect biolink:NamedThing RBO_relaxed.owl RO:0004033 biolink:NamedThing acts upstream of or within, negative effect RBO_relaxed.owl RO:0004034 biolink:NamedThing acts upstream of, positive effect c 'acts upstream of, positive effect' p if c is enables f, and f is causally upstream of p, and the direction of f is positive RBO_relaxed.owl http://wiki.geneontology.org/index.php/Acts_upstream_of,_positive_effect biolink:NamedThing RBO_relaxed.owl RO:0004035 biolink:NamedThing acts upstream of, negative effect c 'acts upstream of, negative effect' p if c is enables f, and f is causally upstream of p, and the direction of f is negative RBO_relaxed.owl http://wiki.geneontology.org/index.php/Acts_upstream_of,_negative_effect biolink:NamedThing RBO_relaxed.owl https://wiki.geneontology.org/Causally_upstream_of_or_within,_positive_effect biolink:NamedThing RBO_relaxed.owl RO:0009501 biolink:NamedThing realized in response to r 'realized in response to' s iff, r is a realizable (e.g. a plant trait such as responsivity to drought), s is an environmental stimulus (a process), and s directly causes the realization of r. RBO_relaxed.owl ORCID:0000-0001-6996-0040 biolink:NamedThing RBO_relaxed.owl ORCID:0000-0002-8461-9745 biolink:NamedThing RBO_relaxed.owl RO:0012003 biolink:NamedThing acts on population of p acts on population of c iff c' is a collection, has members of type c, and p has participant c RBO_relaxed.owl ORCID:0000-0003-1813-6857 biolink:NamedThing RBO_relaxed.owl RO:0012008 biolink:NamedThing results in fusion of RBO_relaxed.owl RO:0012011 biolink:NamedThing indirectly causally upstream of p is indirectly causally upstream of q iff p is causally upstream of q and there exists some process r such that p is causally upstream of r and r is causally upstream of q. RBO_relaxed.owl RO:0015006 biolink:NamedThing different in magnitude relative to q1 different_in_magnitude_relative_to q2 if and only if magnitude(q1) NOT =~ magnitude(q2). Here, magnitude(q) is a function that maps a quality to a unit-invariant scale. RBO_relaxed.owl RO:0015007 biolink:NamedThing increased in magnitude relative to q1 increased_in_magnitude_relative_to q2 if and only if magnitude(q1) > magnitude(q2). Here, magnitude(q) is a function that maps a quality to a unit-invariant scale. RBO_relaxed.owl RO:0015011 biolink:NamedThing has cross section s3 has_cross_section s3 if and only if : there exists some 2d plane that intersects the bearer of s3, and the impression of s3 upon that plane has shape quality s2. RBO_relaxed.owl